Nuclear–cytoplasmic ratio: Difference between revisions
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{{Short description|Measurement used in cell biology}} |
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{{correct title|reason=namespace|edit=omission|title=N:C ratio}} |
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{{More footnotes needed|date=January 2024}} |
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[[File:Nuclear-to-cytoplasm ratios.png|thumb| |
[[File:Nuclear-to-cytoplasm ratios.png|thumb|260px|Nuclear–cytoplasmic ratios.]] |
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The ''' |
The '''nuclear–cytoplasmic ratio''' (also variously known as the '''nucleus:cytoplasm ratio''', '''nucleus–cytoplasm ratio''', '''N:C ratio''', or '''N/C''') is a measurement used in [[cell biology]]. It is a ratio of the size (i.e., volume) of the [[cell nucleus|nucleus]] of a cell to the size of the [[cytoplasm]] of that cell.<ref name="Turgeon">{{cite book | author = Turgeon, Mary Louise | title = Clinical hematology: theory and procedures | publisher = Lippincott Williams & Wilkins | location = Hagerstwon, MD | year = 2005 | pages = 67 | isbn = 0-7817-5007-5 }}</ref> |
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The N:C ratio indicates the maturity of a cell, because as a cell matures the size of its nucleus generally decreases. For example, "blast" forms of [[erythrocyte]]s, [[leukocyte]]s, and [[megakaryocyte]]s start with an N:C ratio of 4:1, which decreases as they mature to 2:1 or even 1:1 (with exceptions for mature [[thrombocyte]]s and erythrocytes, which are [[anuclear cell]]s, and mature [[lymphocyte]]s, which only decrease to a 3:1 ratio and often retain the original 4:1 ratio).<ref name="Turgeon"/> |
The N:C ratio indicates the maturity of a cell, because as a cell matures the size of its nucleus generally decreases. For example, "blast" forms of [[erythrocyte]]s, [[leukocyte]]s, and [[megakaryocyte]]s start with an N:C ratio of 4:1, which decreases as they mature to 2:1 or even 1:1 (with exceptions for mature [[thrombocyte]]s and erythrocytes, which are [[anuclear cell]]s, and mature [[lymphocyte]]s, which only decrease to a 3:1 ratio and often retain the original 4:1 ratio).<ref name="Turgeon"/> |
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==See also== |
==See also== |
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*{{sectionlink|Cell growth|Yeast cell size regulation}} |
* {{sectionlink|Cell growth|Yeast cell size regulation}} |
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*[[Cytopathology]] |
* [[Cytopathology]] |
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*[[Nuclear atypia]] |
* [[Nuclear atypia]] |
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*[[Nuclear pleomorphism]] |
* [[Nuclear pleomorphism]] |
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== References == |
== References == |
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== Further reading == |
== Further reading == |
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{{refbegin}} |
{{refbegin}} |
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* {{cite book|title=Diagnostic cell pathology in tissue and smears|author=Herbert E. Nieburgs|location=New York & London|publisher=Grune & Stratton|date=1967|chapter=Nuclear/Cytoplasmic Ratio (N/C) and Nuclear Chromatin|pages= |
* {{cite book|title=Diagnostic cell pathology in tissue and smears|author=Herbert E. Nieburgs|location=New York & London|publisher=Grune & Stratton|date=1967|chapter=Nuclear/Cytoplasmic Ratio (N/C) and Nuclear Chromatin|pages=15–16}} |
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* {{cite book | author = Takahashi, Masayoshi | title = Color atlas of cancer cytology | edition = 2nd | publisher = Igaku-Shoin | location = New York | year = 1981 | pages = 32–34, 50 | isbn = 0-89640-050-6 }} |
* {{cite book | author = Takahashi, Masayoshi | title = Color atlas of cancer cytology | edition = 2nd | publisher = Igaku-Shoin | location = New York | year = 1981 | pages = 32–34, 50 | isbn = 0-89640-050-6 }} |
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* {{cite book|title=Theory and practice of histological techniques|author1=John D. Bancroft |author2=Alan Stevens |edition=2nd|publisher=Churchill Livingstone|date=1982|pages=438–439}} |
* {{cite book|title=Theory and practice of histological techniques|author1=John D. Bancroft |author2=Alan Stevens |edition=2nd|publisher=Churchill Livingstone|date=1982|pages=438–439}} |
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Latest revision as of 09:19, 7 February 2024
 | This article includes a list of general references, but it lacks sufficient corresponding inline citations. (January 2024) |
The nuclear–cytoplasmic ratio (also variously known as the nucleus:cytoplasm ratio, nucleus–cytoplasm ratio, N:C ratio, or N/C) is a measurement used in cell biology. It is a ratio of the size (i.e., volume) of the nucleus of a cell to the size of the cytoplasm of that cell.[1]
The N:C ratio indicates the maturity of a cell, because as a cell matures the size of its nucleus generally decreases. For example, "blast" forms of erythrocytes, leukocytes, and megakaryocytes start with an N:C ratio of 4:1, which decreases as they mature to 2:1 or even 1:1 (with exceptions for mature thrombocytes and erythrocytes, which are anuclear cells, and mature lymphocytes, which only decrease to a 3:1 ratio and often retain the original 4:1 ratio).[1]
An increased N:C ratio is commonly associated with precancerous dysplasia as well as with malignant cells.
See also
[edit]References
[edit]- ^ a b Turgeon, Mary Louise (2005). Clinical hematology: theory and procedures. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 67. ISBN 0-7817-5007-5.
Further reading
[edit]- Herbert E. Nieburgs (1967). "Nuclear/Cytoplasmic Ratio (N/C) and Nuclear Chromatin". Diagnostic cell pathology in tissue and smears. New York & London: Grune & Stratton. pp. 15–16.
- Takahashi, Masayoshi (1981). Color atlas of cancer cytology (2nd ed.). New York: Igaku-Shoin. pp. 32–34, 50. ISBN 0-89640-050-6.
- John D. Bancroft; Alan Stevens (1982). Theory and practice of histological techniques (2nd ed.). Churchill Livingstone. pp. 438–439.