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{{Infobox scientist
{{Infobox scientist
|name = Timothy J. Ley, MD
|name = Timothy J. Ley, MD
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|caption = Timothy J. Ley
|caption = Timothy J. Ley
|birth_date =
|birth_date =
|work_institutions = [[McDonnell Genome Institute]]<br>[[Washington University School of Medicine]]
|work_institutions = [[Washington University School of Medicine]]
}}
}}
{{DISPLAYTITLE:Timothy J. Ley}}
{{DISPLAYTITLE:Timothy J. Ley}}
'''Timothy J. Ley''' is an American hematologist and cancer biologist. He is the Lewis T. and Rosalind B. Apple Professor of Oncology in the Department of Medicine, is chief of the Section of Stem Cell Biology in the Division of Oncology and is Professor of Genetics at [[Washington University in St. Louis]]. He is an associate director of the [[McDonnell Genome Institute]] at Washington University and is affiliated with the [[Alvin J. Siteman Cancer Center]].<ref>{{cite web | title = Timothy Ley, MD | url = http://www.siteman.wustl.edu/ResearcherProfile.aspx?id=1006&memid=88 | accessdate = 6 August 2012}}</ref>
'''Timothy J. Ley''' is an American hematologist and cancer biologist. He is the Lewis T. and Rosalind B. Apple Professor of Oncology in the department of medicine, and is chief of the section of stem cell biology in the division of oncology at [[Washington University in St. Louis]]. He is a member of the [[Alvin J. Siteman Cancer Center]].<ref>{{cite web | title = Timothy Ley, MD | url = http://www.siteman.wustl.edu/ResearcherProfile.aspx?id=1006&memid=88 | access-date = 6 August 2012}}</ref>


Dr. Ley's research group focuses on the genetics and genomics of [[acute myeloid leukemia]] (AML). His lab studies the development of normal and leukemic blood cells. His work is focused on identifying the mutations that are responsible for the initiation and progression of AML.<ref>[http://news.bbc.co.uk/2/hi/health/8184950.stm "Cancer gene complexity revealed."] "BBC News". 7 August 2009.</ref>
Ley's research group focuses on the genetics and genomics of [[acute myeloid leukemia]] (AML). His lab studies the development of normal and leukemic blood cells. His work is focused on identifying the mutations and epigenetic events that are responsible for the initiation and progression of AML.<ref>[http://news.bbc.co.uk/2/hi/health/8184950.stm "Cancer gene complexity revealed."] "BBC News". 7 August 2009.</ref>


Dr. Ley led the team that sequenced the first cancer genome (of an AML patient).<ref>[https://query.nytimes.com/gst/fullpage.html?res=9804E6D9123DF935A35752C1A96E9C8B63&sec=&spon=&pagewanted=2 "Experts Decode Cancer Patient's Genes, Seeking Treatment Clues."] ''New York Times''. 6 November 2008.</ref> He has gone on to develop projects that will use whole genome sequencing to help diagnose and treat patients with leukemia.<ref>[https://www.nytimes.com/2012/07/08/health/in-gene-sequencing-treatment-for-leukemia-glimpses-of-the-future.html?_r=3 "In Treatment for Leukemia, Glimpses of the Future."] "New York Times". 7 July 2012.</ref>
Ley led the team that sequenced the first cancer genome (of an AML patient).<ref name = "First Cancer Seq">{{cite journal |author=Timothy Ley |title=DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome |journal=Nature |volume=456 |issue=7218 |date=November 2008 |pmid= 18987736
| doi=10.1038/nature07485 |pmc=2603574|display-authors=etal |pages=66–72|bibcode=2008Natur.456...66L }}</ref><ref>[https://query.nytimes.com/gst/fullpage.html?res=9804E6D9123DF935A35752C1A96E9C8B63&sec=&spon=&pagewanted=2 "Experts Decode Cancer Patient's Genes, Seeking Treatment Clues."] ''New York Times''. 6 November 2008.</ref> He has gone on to develop projects that will use whole genome sequencing to help diagnose and treat patients with AML.<ref>[https://www.nytimes.com/2012/07/08/health/in-gene-sequencing-treatment-for-leukemia-glimpses-of-the-future.html?_r=3 "In Treatment for Leukemia, Glimpses of the Future."] "New York Times". 7 July 2012.</ref>


To better understand the role of many of the mutations discovered through whole genome sequencing of leukemias, he and his colleagues have constructed several mouse models of [[acute promyelocytic leukemia]] (APL), which are very similar to human APL.<ref>[http://www.siteman.wustl.edu/internal.aspx?id=476 Siteman Cancer Center History]</ref> Dr. Ley's laboratory has also extensively defined the roles of granzymes for the functions of cytotoxic and regulatory [[T cells]].<ref>[http://www.siteman.wustl.edu/ResearcherProfile.aspx?id=1006&memid=88 Siteman Cancer Center Profile]</ref>
To better understand the role of many of the mutations discovered through whole genome sequencing of leukemias, he and his colleagues have constructed several mouse models of AML, which are very similar to human AML.<ref>[http://www.siteman.wustl.edu/internal.aspx?id=476 Siteman Cancer Center History]</ref> Dr. Ley's laboratory has also helped to define the roles of granzymes for the functions of cytotoxic and regulatory [[T cells]].<ref>[http://www.siteman.wustl.edu/ResearcherProfile.aspx?id=1006&memid=88 Siteman Cancer Center Profile]</ref>


Dr. Ley grew up in [[Lakota, Iowa]]. He received his B.A. degree from [[Drake University]] in 1974, and his M.D. from [[Washington University School of Medicine]] in 1978. He did his internship and residency in Medicine at [[Massachusetts General Hospital]], was a Clinical Associate at the [[NHLBI]] (National Heart, Lung, and Blood Institute), a Hematology-Oncology Fellow at Washington University Medical Center, and a Senior Investigator at the NHLBI before moving to Washington University in 1986.
Ley grew up in [[Lakota, Iowa]]. He received his B.A. degree from [[Drake University]] in 1974, and his M.D. from [[Washington University School of Medicine]] in 1978. He did his internship and residency in Medicine at [[Massachusetts General Hospital]], was a clinical associate at the [[NHLBI]] (National Heart, Lung, and Blood Institute), a Hematology-Oncology Fellow at Washington University Medical Center, and a senior investigator at the NHLBI before moving to Washington University in 1986.


In 2015, Ley was appointed to the National Cancer Advisory Board by President Obama.<ref>[https://www.whitehouse.gov/the-press-office/2015/06/19/president-obama-announces-more-key-administration-posts President Obama Announces More Key Administration Posts]</ref>
In 2015, Ley was appointed to the National Cancer Advisory Board <ref>[http://www.nasonline.org/news-and-multimedia/news/2019-nas-election.html News from the National Academy of Sciences]</ref> by President Obama.<ref>[https://obamawhitehouse.archives.gov/the-press-office/2015/06/19/president-obama-announces-more-key-administration-posts President Obama Announces More Key Administration Posts]</ref> Ley was the recipient of the [[Leopold Griffuel Prize]]<ref>[https://www.fondation-arc.org/50e-prix-fondation-arc-leopold-griffuel Leopold Griffuel Prize]</ref> for Basic Science in 2022.


==Awards and honors==
==Awards and honors==
* Recipient, Leopold Griffuel Prize for Basic Science, Fondation ARC, Paris, France, 2022
* Elected fellow, [[National Academy of Sciences]], 2019<ref>{{cite web |title=2019 NAS Election |url=http://www.nasonline.org/news-and-multimedia/news/2019-nas-election.html |website=www.nasonline.org |accessdate=30 April 2019}}</ref>
* Elected, [[National Academy of Sciences]], 2019
*Alfred G. Knudson Prize for Cancer Genetics, [[National Cancer Institute]], 2015
*Alfred G. Knudson Prize for Cancer Genetics, [[National Cancer Institute]], 2015
*Recipient, The Erasmus Hematology Award, [[Erasmus MC]], 2015
*Recipient, The Erasmus Hematology Award, [[Erasmus MC]], 2015
*Recipient, E. Donnall Thomas Prize, [[American Society of Hematology]], 2012
*Recipient, E. Donnall Thomas Prize, [[American Society of Hematology]], 2012
*Recipient, The George Engelmann Interdisciplinary Award, [[Academy of Science, St. Louis]], 2012
*Recipient, The George Engelmann Interdisciplinary Award, [[Academy of Science, St. Louis]], 2012
*Fellow, [[American Academy of Arts and Sciences]], 2010
*Elected, [[American Academy of Arts and Sciences]], 2010
*Treasurer, [[Association of American Physicians]], 2007–2012
*Treasurer, [[Association of American Physicians]], 2007–2012
*Member, [[National Academy of Medicine]], 2003
*Elected, [[National Academy of Medicine]], 2003
*Fellow, [[American Association for the Advancement of Science]], 2002
*Fellow, [[American Association for the Advancement of Science]], 2002
*President, [[American Society for Clinical Investigation]], 1997–1998
*President, [[American Society for Clinical Investigation]], 1997–1998
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==External links==
==External links==
*[http://genome.wustl.edu/people/ley_timothy McDonnell Institute Bio]
*[https://oncology.wustl.edu/people/faculty/Ley/Ley_Bio.html Divisions of Hematology and Oncology]
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*[https://www.ncbi.nlm.nih.gov/pubmed?term=%22Ley%20TJ%22 Ley PubMed Citations]
*[http://hematology.wustl.edu/faculty/ley/leyBio.html Divisions of Hematology & Oncology Bio]
*[http://www.wuphysicians.com/physician2.aspx?PhysNum=1043 Washington University Physicians Bio]
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*[https://www.ncbi.nlm.nih.gov/pubmed?term=%22Ley%20TJ%22[Author&#93; PubMed Citations]
*[http://www.stlmag.com/media/St-Louis-Magazine/June-2009/Healthy-Living-The-Code-Breakers/ "Healthy Living: The Code Breakers."] ''St. Louis Magazine.'' 2009 June.
*[http://news.bbc.co.uk/2/hi/health/8184950.stm "Cancer gene complexity revealed."] ''BBC News.'' 7 August 2009.
*[http://news.bbc.co.uk/2/hi/health/8184950.stm "Cancer gene complexity revealed."] ''BBC News.'' 7 August 2009.


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{{DEFAULTSORT:Ley, Timothy}}
{{DEFAULTSORT:Ley, Timothy}}
[[Category:1953 births]]
[[Category:1953 births]]
[[Category:Living people]]
[[Category:Living people]]
[[Category:Cancer genomics]]
[[Category:Members of the National Academy of Medicine]]
[[Category:Fellows of the American Academy of Arts and Sciences]]
[[Category:Washington University in St. Louis fellows]]
[[Category:Washington University School of Medicine faculty]]
[[Category:Washington University School of Medicine alumni]]
[[Category:Drake University alumni]]

Latest revision as of 21:34, 9 February 2024

Timothy J. Ley, MD
Timothy J. Ley
Scientific career
InstitutionsWashington University School of Medicine

Timothy J. Ley is an American hematologist and cancer biologist. He is the Lewis T. and Rosalind B. Apple Professor of Oncology in the department of medicine, and is chief of the section of stem cell biology in the division of oncology at Washington University in St. Louis. He is a member of the Alvin J. Siteman Cancer Center.[1]

Ley's research group focuses on the genetics and genomics of acute myeloid leukemia (AML). His lab studies the development of normal and leukemic blood cells. His work is focused on identifying the mutations and epigenetic events that are responsible for the initiation and progression of AML.[2]

Ley led the team that sequenced the first cancer genome (of an AML patient).[3][4] He has gone on to develop projects that will use whole genome sequencing to help diagnose and treat patients with AML.[5]

To better understand the role of many of the mutations discovered through whole genome sequencing of leukemias, he and his colleagues have constructed several mouse models of AML, which are very similar to human AML.[6] Dr. Ley's laboratory has also helped to define the roles of granzymes for the functions of cytotoxic and regulatory T cells.[7]

Ley grew up in Lakota, Iowa. He received his B.A. degree from Drake University in 1974, and his M.D. from Washington University School of Medicine in 1978. He did his internship and residency in Medicine at Massachusetts General Hospital, was a clinical associate at the NHLBI (National Heart, Lung, and Blood Institute), a Hematology-Oncology Fellow at Washington University Medical Center, and a senior investigator at the NHLBI before moving to Washington University in 1986.

In 2015, Ley was appointed to the National Cancer Advisory Board [8] by President Obama.[9] Ley was the recipient of the Leopold Griffuel Prize[10] for Basic Science in 2022.

Awards and honors

[edit]

References

[edit]
  1. ^ "Timothy Ley, MD". Retrieved 6 August 2012.
  2. ^ "Cancer gene complexity revealed." "BBC News". 7 August 2009.
  3. ^ Timothy Ley; et al. (November 2008). "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome". Nature. 456 (7218): 66–72. Bibcode:2008Natur.456...66L. doi:10.1038/nature07485. PMC 2603574. PMID 18987736.
  4. ^ "Experts Decode Cancer Patient's Genes, Seeking Treatment Clues." New York Times. 6 November 2008.
  5. ^ "In Treatment for Leukemia, Glimpses of the Future." "New York Times". 7 July 2012.
  6. ^ Siteman Cancer Center History
  7. ^ Siteman Cancer Center Profile
  8. ^ News from the National Academy of Sciences
  9. ^ President Obama Announces More Key Administration Posts
  10. ^ Leopold Griffuel Prize
[edit]
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