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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{PBB|geneid=10057}}
{{Infobox_gene}}
'''Multidrug resistance-associated protein 5''' is a [[protein]] that in humans is encoded by the ''ABCC5'' [[gene]].<ref name="pmid8894702">{{cite journal | author = Allikmets R, Gerrard B, Hutchinson A, Dean M | title = Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database | journal = Hum Mol Genet | volume = 5 | issue = 10 | pages = 1649–55 |date=Feb 1997 | pmid = 8894702 | pmc = | doi =10.1093/hmg/5.10.1649 }}</ref><ref name="pmid9827529">{{cite journal | author = Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD | title = Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins | journal = J Natl Cancer Inst | volume = 90 | issue = 22 | pages = 1735–41 |date=Dec 1998 | pmid = 9827529 | pmc = | doi =10.1093/jnci/90.22.1735 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10057| accessdate = }}</ref>
'''Multidrug resistance-associated protein 5''' is a [[protein]] that in humans is encoded by the ''ABCC5'' [[gene]].<ref name="pmid8894702">{{cite journal | vauthors = Allikmets R, Gerrard B, Hutchinson A, Dean M | title = Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database | journal = Human Molecular Genetics | volume = 5 | issue = 10 | pages = 1649–55 | date = Oct 1996 | pmid = 8894702 | doi = 10.1093/hmg/5.10.1649 | doi-access = free }}</ref><ref name="pmid9827529">{{cite journal | vauthors = Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD | title = Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins | journal = Journal of the National Cancer Institute | volume = 90 | issue = 22 | pages = 1735–41 | date = Nov 1998 | pmid = 9827529 | doi = 10.1093/jnci/90.22.1735 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10057}}</ref>


== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->

{{PBB_Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.
| section_title =

| summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.<ref name="entrez"/>
This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides.
}}

Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercaptopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.

Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.<ref name="entrez" />


== Interactive pathway map ==
== Interactive pathway map ==
{{FluoropyrimidineActivity WP1601|highlight=ABCC5}}
{{FluoropyrimidineActivity WP1601|highlight=ABCC5}}


==See also==
== See also ==
* [[ATP-binding cassette transporter]]
* [[ATP-binding cassette transporter]]


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F, Borst P | title = Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines | journal = Cancer Research | volume = 57 | issue = 16 | pages = 3537–47 | date = Aug 1997 | pmid = 9270026 }}
{{PBB_Further_reading
* {{cite journal | vauthors = Suzuki T, Nishio K, Sasaki H, Kurokawa H, Saito-Ohara F, Ikeuchi T, Tanabe S, Terada M, Saijo N | title = cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line | journal = Biochemical and Biophysical Research Communications | volume = 238 | issue = 3 | pages = 790–4 | date = Sep 1997 | pmid = 9325169 | doi = 10.1006/bbrc.1997.7346 }}
| citations =
* {{cite journal | vauthors = Cole SP | title = Re: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins | journal = Journal of the National Cancer Institute | volume = 91 | issue = 10 | pages = 888–9 | date = May 1999 | pmid = 10340910 | doi = 10.1093/jnci/91.10.888 | doi-access = free }}
*{{cite journal | author=Kool M |title=Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines |journal=Cancer Res. |volume=57 |issue= 16 |pages= 3537–47 |year= 1997 |pmid= 9270026 |doi= | name-list-format=vanc | author2=de Haas M | author3=Scheffer GL | display-authors=3 | last4=Scheper | first4=RJ | last5=Van Eijk | first5=MJ | last6=Juijn | first6=JA | last7=Baas | first7=F | last8=Borst | first8=P }}
* {{cite journal | vauthors = McAleer MA, Breen MA, White NL, Matthews N | title = pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 33 | pages = 23541–8 | date = Aug 1999 | pmid = 10438534 | doi = 10.1074/jbc.274.33.23541 | doi-access = free }}
*{{cite journal | author=Suzuki T |title=cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 3 |pages= 790–4 |year= 1997 |pmid= 9325169 |doi= 10.1006/bbrc.1997.7346 | name-list-format=vanc | author2=Nishio K | author3=Sasaki H | display-authors=3 | last4=Kurokawa | first4=Hirokazu | last5=Saito-Ohara | first5=Fumiko | last6=Ikeuchi | first6=Tatsuro | last7=Tanabe | first7=Shinzo | last8=Terada | first8=Masaaki | last9=Saijo | first9=Nagahiro }}
*{{cite journal | author=Cole SP |title=Re: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins |journal=J. Natl. Cancer Inst. |volume=91 |issue= 10 |pages= 888–9 |year= 1999 |pmid= 10340910 |doi=10.1093/jnci/91.10.888 }}
* {{cite journal | vauthors = Suzuki T, Sasaki H, Kuh HJ, Agui M, Tatsumi Y, Tanabe S, Terada M, Saijo N, Nishio K | title = Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts | journal = Gene | volume = 242 | issue = 1–2 | pages = 167–73 | date = Jan 2000 | pmid = 10721709 | doi = 10.1016/S0378-1119(99)00529-6 }}
*{{cite journal | author=McAleer MA, Breen MA, White NL, Matthews N |title=pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23541–8 |year= 1999 |pmid= 10438534 |doi=10.1074/jbc.274.33.23541 }}
* {{cite journal | vauthors = Oguri T, Isobe T, Suzuki T, Nishio K, Fujiwara Y, Katoh O, Yamakido M | title = Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer | journal = International Journal of Cancer | volume = 86 | issue = 1 | pages = 95–100 | date = Apr 2000 | pmid = 10728601 | doi = 10.1002/(SICI)1097-0215(20000401)86:1<95::AID-IJC15>3.0.CO;2-G | doi-access = free }}
* {{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 7 | pages = 3491–6 | date = Mar 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491 | bibcode = 2000PNAS...97.3491D | doi-access = free }}
*{{cite journal | author=Suzuki T |title=Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts |journal=Gene |volume=242 |issue= 1–2 |pages= 167–73 |year= 2000 |pmid= 10721709 |doi=10.1016/S0378-1119(99)00529-6 | name-list-format=vanc | author2=Sasaki H | author3=Kuh HJ | display-authors=3 | last4=Agui | first4=Mika | last5=Tatsumi | first5=Yasuaki | last6=Tanabe | first6=Shinzo | last7=Terada | first7=Masaaki | last8=Saijo | first8=Nagahiro | last9=Nishio | first9=Kazuto }}
* {{cite journal | vauthors = Wijnholds J, Mol CA, van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J, Borst P | title = Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 13 | pages = 7476–81 | date = Jun 2000 | pmid = 10840050 | pmc = 16570 | doi = 10.1073/pnas.120159197 | bibcode = 2000PNAS...97.7476W | doi-access = free }}
*{{cite journal | author=Oguri T |title=Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer |journal=Int. J. Cancer |volume=86 |issue= 1 |pages= 95–100 |year= 2000 |pmid= 10728601 |doi=10.1002/(SICI)1097-0215(20000401)86:1<95::AID-IJC15>3.0.CO;2-G | name-list-format=vanc | author2=Isobe T | author3=Suzuki T | display-authors=3 | last4=Nishio | first4=Kazuto | last5=Fujiwara | first5=Yasuhiro | last6=Katoh | first6=Osamu | last7=Yamakido | first7=Michio }}
* {{cite journal | vauthors = Jedlitschky G, Burchell B, Keppler D | title = The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides | journal = The Journal of Biological Chemistry | volume = 275 | issue = 39 | pages = 30069–74 | date = Sep 2000 | pmid = 10893247 | doi = 10.1074/jbc.M005463200 | doi-access = free }}
*{{cite journal | author=Dias Neto E |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 | name-list-format=vanc | author2=Correa RG | author3=Verjovski-Almeida S | display-authors=3 | last4=Briones | first4=MR | last5=Nagai | first5=MA | last6=Da Silva Jr | first6=W | last7=Zago | first7=MA | last8=Bordin | first8=S | last9=Costa | first9=FF }}
* {{cite journal | vauthors = Alcorn J, Lu X, Moscow JA, McNamara PJ | title = Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 303 | issue = 2 | pages = 487–96 | date = Nov 2002 | pmid = 12388627 | doi = 10.1124/jpet.102.038315 | s2cid = 16195525 }}
*{{cite journal | author=Wijnholds J |title=Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7476–81 |year= 2000 |pmid= 10840050 |doi= 10.1073/pnas.120159197 | pmc=16570 | name-list-format=vanc | author2=Mol CA | author3=van Deemter L | display-authors=3 | last4=De Haas | first4=M | last5=Scheffer | first5=GL | last6=Baas | first6=F | last7=Beijnen | first7=JH | last8=Scheper | first8=RJ | last9=Hatse | first9=S }}
*{{cite journal | author=Jedlitschky G, Burchell B, Keppler D |title=The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30069–74 |year= 2000 |pmid= 10893247 |doi= 10.1074/jbc.M005463200 }}
* {{cite journal | vauthors = Wielinga PR, van der Heijden I, Reid G, Beijnen JH, Wijnholds J, Borst P | title = Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 20 | pages = 17664–71 | date = May 2003 | pmid = 12637526 | doi = 10.1074/jbc.M212723200 | doi-access = free }}
*{{cite journal | author=Alcorn J, Lu X, Moscow JA, McNamara PJ |title=Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction |journal=J. Pharmacol. Exp. Ther. |volume=303 |issue= 2 |pages= 487–96 |year= 2002 |pmid= 12388627 |doi= 10.1124/jpet.102.038315 }}
* {{cite journal | vauthors = Pascolo L, Fernetti C, Pirulli D, Crovella S, Amoroso A, Tiribelli C|author6-link=Claudio Tiribelli | title = Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells | journal = Biochemical and Biophysical Research Communications | volume = 303 | issue = 1 | pages = 259–65 | date = Mar 2003 | pmid = 12646196 | doi = 10.1016/S0006-291X(03)00327-9 }}
* {{cite journal | vauthors = Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P | s2cid = 7444400 | title = Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5 | journal = Molecular Pharmacology | volume = 63 | issue = 5 | pages = 1094–103 | date = May 2003 | pmid = 12695538 | doi = 10.1124/mol.63.5.1094 }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | name-list-format=vanc | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
* {{cite journal | vauthors = Dazert P, Meissner K, Vogelgesang S, Heydrich B, Eckel L, Böhm M, Warzok R, Kerb R, Brinkmann U, Schaeffeler E, Schwab M, Cascorbi I, Jedlitschky G, Kroemer HK | title = Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart | journal = The American Journal of Pathology | volume = 163 | issue = 4 | pages = 1567–77 | date = Oct 2003 | pmid = 14507663 | pmc = 1868287 | doi = 10.1016/S0002-9440(10)63513-4 }}
*{{cite journal | author=Wielinga PR |title=Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17664–71 |year= 2003 |pmid= 12637526 |doi= 10.1074/jbc.M212723200 | name-list-format=vanc | author2=van der Heijden I | author3=Reid G | display-authors=3 | last4=Beijnen | first4=JH | last5=Wijnholds | first5=J | last6=Borst | first6=P }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = Jun 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | s2cid = 27764390 }}
*{{cite journal | author=Pascolo L |title=Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 1 |pages= 259–65 |year= 2003 |pmid= 12646196 |doi=10.1016/S0006-291X(03)00327-9 | name-list-format=vanc | author2=Fernetti C | author3=Pirulli D | display-authors=3 | last4=Crovella | first4=Sergio | last5=Amoroso | first5=Antonio | last6=Tiribelli | first6=Claudio }}
⚫
* {{cite journal | vauthors = Jedlitschky G, Tirschmann K, Lubenow LE, Nieuwenhuis HK, Akkerman JW, Greinacher A, Kroemer HK | title = The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage | journal = Blood | volume = 104 | issue = 12 | pages = 3603–10 | date = Dec 2004 | pmid = 15297306 | doi = 10.1182/blood-2003-12-4330 | doi-access = free }}
*{{cite journal | author=Reid G |title=Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5 |journal=Mol. Pharmacol. |volume=63 |issue= 5 |pages= 1094–103 |year= 2003 |pmid= 12695538 |doi=10.1124/mol.63.5.1094 | name-list-format=vanc | author2=Wielinga P | author3=Zelcer N | display-authors=3 | last4=De Haas | first4=M | last5=Van Deemter | first5=L | last6=Wijnholds | first6=J | last7=Balzarini | first7=J | last8=Borst | first8=P }}
⚫
* {{cite journal | vauthors = Meyer Zu Schwabedissen HE, Grube M, Heydrich B, Linnemann K, Fusch C, Kroemer HK, Jedlitschky G | title = Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation | journal = The American Journal of Pathology | volume = 166 | issue = 1 | pages = 39–48 | date = Jan 2005 | pmid = 15631998 | pmc = 1602292 | doi = 10.1016/S0002-9440(10)62230-4 }}
*{{cite journal | author=Dazert P |title=Expression and Localization of the Multidrug Resistance Protein 5 (MRP5/ABCC5), a Cellular Export Pump for Cyclic Nucleotides, in Human Heart |journal=Am. J. Pathol. |volume=163 |issue= 4 |pages= 1567–77 |year= 2003 |pmid= 14507663 |doi= 10.1016/S0002-9440(10)63513-4| pmc=1868287 | name-list-format=vanc | author2=Meissner K | author3=Vogelgesang S | display-authors=3 | last4=Heydrich | first4=B | last5=Eckel | first5=L | last6=Böhm | first6=M | last7=Warzok | first7=R | last8=Kerb | first8=R | last9=Brinkmann | first9=U }}
*{{cite journal | author=Brandenberger R |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 | name-list-format=vanc | author2=Wei H | author3=Zhang S | display-authors=3 | last4=Lei | first4=Shirley | last5=Murage | first5=Jaji | last6=Fisk | first6=Gregory J | last7=Li | first7=Yan | last8=Xu | first8=Chunhui | last9=Fang | first9=Rixun }}
⚫
*{{cite journal | author=Jedlitschky G |title=The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage |journal=Blood |volume=104 |issue= 12 |pages= 3603–10 |year= 2004 |pmid= 15297306 |doi= 10.1182/blood-2003-12-4330 | name-list-format=vanc | author2=Tirschmann K | author3=Lubenow LE | display-authors=3 | last4=Nieuwenhuis | first4=HK | last5=Akkerman | first5=JW | last6=Greinacher | first6=A | last7=Kroemer | first7=HK }}
⚫
*{{cite journal | author=Meyer Zu Schwabedissen HE |title=Expression, Localization, and Function of MRP5 (ABCC5), a Transporter for Cyclic Nucleotides, in Human Placenta and Cultured Human Trophoblasts : Effects of Gestational Age and Cellular Differentiation |journal=Am. J. Pathol. |volume=166 |issue= 1 |pages= 39–48 |year= 2005 |pmid= 15631998 |doi= 10.1016/S0002-9440(10)62230-4| pmc=1602292 | name-list-format=vanc}}
}}
{{refend}}
{{refend}}


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Latest revision as of 01:54, 12 February 2024

ABCC5
Identifiers
AliasesABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11, ATP binding cassette subfamily C member 5
External IDsOMIM: 605251; MGI: 1351644; HomoloGene: 21164; GeneCards: ABCC5; OMA:ABCC5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10057

27416

Ensembl

ENSG00000114770

ENSMUSG00000022822

UniProt

O15440

Q9R1X5

RefSeq (mRNA)

NM_001023587
NM_005688
NM_001320032

NM_013790
NM_176839

RefSeq (protein)

NP_001018881
NP_001306961
NP_005679

NP_038818
NP_789809

Location (UCSC)Chr 3: 183.92 – 184.02 MbChr 16: 20.15 – 20.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene.[5][6][7]

Function

[edit]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.

This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides.

Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercaptopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.

Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.[7]

Interactive pathway map

[edit]

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:
FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114770 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022822 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Oct 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  6. ^ Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD (Nov 1998). "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins". Journal of the National Cancer Institute. 90 (22): 1735–41. doi:10.1093/jnci/90.22.1735. PMID 9827529.
  7. ^ a b "Entrez Gene: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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