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{{PBB|geneid=5654}}
{{Short description|Protein-coding gene in the species Homo sapiens}}
⚫
'''Serine protease HTRA1''' is an [[enzyme]] that in humans is encoded by the ''HTRA1'' [[gene]].<ref name="pmid8977104">{{cite journal | author = Zumbrunn J, Trueb B | title = Primary structure of a putative serine protease specific for IGF-binding proteins | journal = FEBS Lett | volume = 398 | issue = 2–3 | pages = 187–92 | year = 1997 | month = Jan | pmid = 8977104 | pmc = | doi =10.1016/S0014-5793(96)01229-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HTRA1 HtrA serine peptidase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5654| accessdate = }}</ref> The HTRA1 protein is composed of four distinct [[protein domain]]s. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a [[kazal domain]], a [[trypsin]]-like peptidase domain and a [[PDZ domain]].
{{Infobox_gene}}
⚫
'''Serine protease HTRA1''' is an [[enzyme]] that in humans is encoded by the ''HTRA1'' [[gene]].<ref name="pmid8977104">{{cite journal |vauthors=Zumbrunn J, Trueb B | title = Primary structure of a putative serine protease specific for IGF-binding proteins | journal = FEBS Lett | volume = 398 | issue = 2–3 | pages = 187–92 |date=Jan 1997 | pmid = 8977104 | doi =10.1016/S0014-5793(96)01229-X | s2cid = 39934612 | doi-access = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HTRA1 HtrA serine peptidase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5654}}</ref> The HTRA1 protein is composed of four distinct [[protein domain]]s. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a [[kazal domain]], a [[trypsin]]-like peptidase domain and a [[PDZ domain]].


⚫
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.<ref name="entrez"/>
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{{PBB_Summary
Mutations of this gene are responsible for the development of [[CARASIL]], a genetic form of cerebral vasculopathy.
| section_title =
⚫
| summary_text = This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.<ref name="entrez"/>
}}


==References==
==References==
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==External links==
==External links==
* [http://www.ncbi.nlm.nih.gov/books/NBK32533/ GeneReviews/NCBI/NIH/UW entry on CARASIL Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, Maeda Syndrome]
* [https://www.ncbi.nlm.nih.gov/books/NBK32533/ GeneReviews/NCBI/NIH/UW entry on CARASIL Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, Maeda Syndrome]
* [http://www.ncbi.nlm.nih.gov/omim/610149,600142,602194,600142,602194 OMIM entries on CARASIL]
* [https://www.ncbi.nlm.nih.gov/omim/610149,600142,602194,600142,602194 OMIM entries on CARASIL]


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
⚫
*{{Cite journal |doi=10.1038/eye.2011.37 |title=Complement in age-related macular degeneration: a focus on function |year=2011 |last1=Bradley |first1=D T |last2=Zipfel |first2=P F |last3=Hughes |first3=A E |journal=Eye |volume=25 |issue=6 |pages=683–693 |pmid=21394116 |pmc=3178140}}
{{PBB_Further_reading
*{{cite journal |vauthors=Zurawa-Janicka D, Narkiewicz J, Lipińska B |title=[Characterization of the HtrA family of proteins] |journal=Postepy Biochem. |volume=53 |issue= 1 |pages= 27–36 |year= 2007 |pmid= 17718385 }}
| citations =
*{{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
⚫
*{{Cite journal |doi=10.1038/eye.2011.37 |title=Complement in age-related macular degeneration: a focus on function |year=2011 |last1=Bradley |first1=D T |last2=Zipfel |first2=P F |last3=Hughes |first3=A E |journal=Eye}}
*{{cite journal | author=Zurawa-Janicka D, Narkiewicz J, Lipińska B |title=[Characterization of the HtrA family of proteins] |journal=Postepy Biochem. |volume=53 |issue= 1 |pages= 27–36 |year= 2007 |pmid= 17718385 |doi= }}
*{{cite journal |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal |vauthors=Zumbrunn J, Trueb B |title=Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2 |journal=Genomics |volume=45 |issue= 2 |pages= 461–2 |year= 1998 |pmid= 9344681 |doi= 10.1006/geno.1997.4953 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= | pmc=139146 }}
*{{cite journal |vauthors=Hu SI, Carozza M, Klein M, etal |title=Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34406–12 |year= 1999 |pmid= 9852107 |doi=10.1074/jbc.273.51.34406 |doi-access=free }}
*{{cite journal | author=Zumbrunn J, Trueb B |title=Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2 |journal=Genomics |volume=45 |issue= 2 |pages= 461–2 |year= 1998 |pmid= 9344681 |doi= 10.1006/geno.1997.4953 }}
*{{cite journal |vauthors=Baldi A, De Luca A, Morini M, etal |title=The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells |journal=Oncogene |volume=21 |issue= 43 |pages= 6684–8 |year= 2002 |pmid= 12242667 |doi= 10.1038/sj.onc.1205911 |s2cid=9021435 |doi-access=free }}
*{{cite journal | author=Hu SI, Carozza M, Klein M, ''et al.'' |title=Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34406–12 |year= 1999 |pmid= 9852107 |doi=10.1074/jbc.273.51.34406 }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal | author=Baldi A, De Luca A, Morini M, ''et al.'' |title=The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells |journal=Oncogene |volume=21 |issue= 43 |pages= 6684–8 |year= 2002 |pmid= 12242667 |doi= 10.1038/sj.onc.1205911 }}
*{{cite journal |vauthors=Nie GY, Hampton A, Li Y, etal |title=Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2 |journal=Biochem. J. |volume=371 |issue= Pt 1 |pages= 39–48 |year= 2003 |pmid= 12513693 |doi= 10.1042/BJ20021569 | pmc=1223265 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal |vauthors=De Luca A, De Falco M, Severino A, etal |title=Distribution of the serine protease HtrA1 in normal human tissues |journal=J. Histochem. Cytochem. |volume=51 |issue= 10 |pages= 1279–84 |year= 2003 |pmid= 14500695 |doi= 10.1177/002215540305101004|s2cid=19726897 |doi-access= }}
*{{cite journal | author=Nie GY, Hampton A, Li Y, ''et al.'' |title=Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2 |journal=Biochem. J. |volume=371 |issue= Pt 1 |pages= 39–48 |year= 2003 |pmid= 12513693 |doi= 10.1042/BJ20021569 | pmc=1223265 }}
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal | author=De Luca A, De Falco M, Severino A, ''et al.'' |title=Distribution of the serine protease HtrA1 in normal human tissues |journal=J. Histochem. Cytochem. |volume=51 |issue= 10 |pages= 1279–84 |year= 2003 |pmid= 14500695 |doi= }}
*{{cite journal |vauthors=Chien J, Staub J, Hu SI, etal |title=A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer |journal=Oncogene |volume=23 |issue= 8 |pages= 1636–44 |year= 2004 |pmid= 14716297 |doi= 10.1038/sj.onc.1207271 |doi-access= free }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal |vauthors=Oka C, Tsujimoto R, Kajikawa M, etal |title=HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins |journal=Development |volume=131 |issue= 5 |pages= 1041–53 |year= 2004 |pmid= 14973287 |doi= 10.1242/dev.00999 |s2cid=27495047 |doi-access= }}
*{{cite journal | author=Chien J, Staub J, Hu SI, ''et al.'' |title=A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer |journal=Oncogene |volume=23 |issue= 8 |pages= 1636–44 |year= 2004 |pmid= 14716297 |doi= 10.1038/sj.onc.1207271 }}
*{{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Oka C, Tsujimoto R, Kajikawa M, ''et al.'' |title=HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins |journal=Development |volume=131 |issue= 5 |pages= 1041–53 |year= 2004 |pmid= 14973287 |doi= 10.1242/dev.00999 }}
*{{cite journal |vauthors=Grau S, Baldi A, Bussani R, etal |title=Implications of the serine protease HtrA1 in amyloid precursor protein processing |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 17 |pages= 6021–6 |year= 2005 |pmid= 15855271 |doi= 10.1073/pnas.0501823102 | pmc=1087941 |doi-access=free }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal |vauthors=Ozturk A, Desai PP, Minster RL, etal |title=Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease |journal=Neurobiol. Aging |volume=26 |issue= 8 |pages= 1161–5 |year= 2005 |pmid= 15917099 |doi= 10.1016/j.neurobiolaging.2004.11.001 |s2cid=10878355 }}
*{{cite journal | author=Grau S, Baldi A, Bussani R, ''et al.'' |title=Implications of the serine protease HtrA1 in amyloid precursor protein processing |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 17 |pages= 6021–6 |year= 2005 |pmid= 15855271 |doi= 10.1073/pnas.0501823102 | pmc=1087941 }}
*{{cite journal |vauthors=Grau S, Richards PJ, Kerr B, etal |title=The role of human HtrA1 in arthritic disease |journal=J. Biol. Chem. |volume=281 |issue= 10 |pages= 6124–9 |year= 2006 |pmid= 16377621 |doi= 10.1074/jbc.M500361200 |doi-access= free }}
*{{cite journal | author=Ozturk A, Desai PP, Minster RL, ''et al.'' |title=Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease |journal=Neurobiol. Aging |volume=26 |issue= 8 |pages= 1161–5 |year= 2005 |pmid= 15917099 |doi= 10.1016/j.neurobiolaging.2004.11.001 }}
*{{cite journal |vauthors=Bowden MA, Di Nezza-Cossens LA, Jobling T, etal |title=Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer |journal=Gynecol. Oncol. |volume=103 |issue= 1 |pages= 253–60 |year= 2006 |pmid= 16650464 |doi= 10.1016/j.ygyno.2006.03.006 }}
*{{cite journal | author=Grau S, Richards PJ, Kerr B, ''et al.'' |title=The role of human HtrA1 in arthritic disease |journal=J. Biol. Chem. |volume=281 |issue= 10 |pages= 6124–9 |year= 2006 |pmid= 16377621 |doi= 10.1074/jbc.M500361200 }}
*{{cite journal |vauthors=Chien J, Aletti G, Baldi A, etal |title=Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity |journal=J. Clin. Invest. |volume=116 |issue= 7 |pages= 1994–2004 |year= 2006 |pmid= 16767218 |doi= 10.1172/JCI27698 | pmc=1474818 }}
*{{cite journal | author=Bowden MA, Di Nezza-Cossens LA, Jobling T, ''et al.'' |title=Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer |journal=Gynecol. Oncol. |volume=103 |issue= 1 |pages= 253–60 |year= 2006 |pmid= 16650464 |doi= 10.1016/j.ygyno.2006.03.006 }}
*{{cite journal |vauthors=Dewan A, Liu M, Hartman S, etal |title=HTRA1 promoter polymorphism in wet age-related macular degeneration |journal=Science |volume=314 |issue= 5801 |pages= 989–92 |year= 2006 |pmid= 17053108 |doi= 10.1126/science.1133807 |s2cid=85725181 }}
*{{cite journal | author=Chien J, Aletti G, Baldi A, ''et al.'' |title=Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity |journal=J. Clin. Invest. |volume=116 |issue= 7 |pages= 1994–2004 |year= 2006 |pmid= 16767218 |doi= 10.1172/JCI27698 | pmc=1474818 }}
*{{cite journal | author=Dewan A, Liu M, Hartman S, ''et al.'' |title=HTRA1 promoter polymorphism in wet age-related macular degeneration |journal=Science |volume=314 |issue= 5801 |pages= 989–92 |year= 2006 |pmid= 17053108 |doi= 10.1126/science.1133807 }}
}}
{{refend}}
{{refend}}

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{{gene-10-stub}}
{{gene-10-stub}}

Latest revision as of 12:07, 14 February 2024

HTRA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHTRA1, ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11, CADASIL2, HtrA serine peptidase 1
External IDsOMIM: 602194; MGI: 1929076; HomoloGene: 31114; GeneCards: HTRA1; OMA:HTRA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5654

56213

Ensembl

ENSG00000166033

ENSMUSG00000006205

UniProt

Q92743

Q9R118

RefSeq (mRNA)

NM_002775

NM_019564

RefSeq (protein)

NP_002766

NP_062510

Location (UCSC)Chr 10: 122.46 – 122.51 MbChr 7: 130.54 – 130.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene.[5][6] The HTRA1 protein is composed of four distinct protein domains. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a kazal domain, a trypsin-like peptidase domain and a PDZ domain.

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.[6]

Mutations of this gene are responsible for the development of CARASIL, a genetic form of cerebral vasculopathy.

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166033 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006205 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zumbrunn J, Trueb B (Jan 1997). "Primary structure of a putative serine protease specific for IGF-binding proteins". FEBS Lett. 398 (2–3): 187–92. doi:10.1016/S0014-5793(96)01229-X. PMID 8977104. S2CID 39934612.
  6. ^ a b "Entrez Gene: HTRA1 HtrA serine peptidase 1".
[edit]

Further reading

[edit]
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