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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Alpha-protein kinase 1''' is an [[enzyme]] that in [[human]]s is encoded by the ''ALPK1'' [[gene]].<ref name="pmid10021370">{{cite journal | vauthors = Ryazanov AG, Pavur KS, Dorovkov MV | title = Alpha-kinases: a new class of protein kinases with a novel catalytic domain | journal = Curr Biol | volume = 9 | issue = 2 | pages = R43–5 |date=Mar 1999 | pmid = 10021370 | doi =10.1016/S0960-9822(99)80006-2 | s2cid = 34505206 }}</ref><ref name="pmid10819331">{{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 2 | pages = 143–50 |date=Sep 2000 | pmid = 10819331 | doi =10.1093/dnares/7.2.143 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ALPK1 alpha-kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80216}}</ref>
'''Alpha-protein kinase 1''' is an [[enzyme]] that in [[human]]s is encoded by the ''ALPK1'' [[gene]].<ref name="pmid10021370">{{cite journal | vauthors = Ryazanov AG, Pavur KS, Dorovkov MV | title = Alpha-kinases: a new class of protein kinases with a novel catalytic domain | journal = Curr Biol | volume = 9 | issue = 2 | pages = R43–5 |date=Mar 1999 | pmid = 10021370 | doi =10.1016/S0960-9822(99)80006-2 | s2cid = 34505206 | doi-access = free | bibcode = 1999CBio....9..R43R }}</ref><ref name="pmid10819331">{{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 2 | pages = 143–50 |date=Sep 2000 | pmid = 10819331 | doi =10.1093/dnares/7.2.143 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ALPK1 alpha-kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80216}}</ref>


Unlike most [[eukaryotic]] [[kinase]]s, [[alpha kinases]], such as LAK, recognize [[phosphorylation]] sites in which the surrounding [[peptide]]s have an [[alpha-helical]] conformation.[supplied by OMIM]<ref name="entrez" />
Unlike most [[eukaryotic]] [[kinase]]s, alpha kinases, such as LAK, recognize [[phosphorylation]] sites in which the surrounding [[peptide]]s have an [[alpha-helical]] conformation.[supplied by OMIM]<ref name="entrez" />


==References==
==References==
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{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 |display-authors=etal}}
*{{cite journal | vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 |bibcode=2000PNAS...97.3491D |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Yamada S, Ohira M, Horie H |title=Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas |journal=Oncogene |volume=23 |issue= 35 |pages= 5901–11 |year= 2004 |pmid= 15221005 |doi= 10.1038/sj.onc.1207782 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Yamada S, Ohira M, Horie H |title=Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas |journal=Oncogene |volume=23 |issue= 35 |pages= 5901–11 |year= 2004 |pmid= 15221005 |doi= 10.1038/sj.onc.1207782 |display-authors=etal|doi-access=free }}

Latest revision as of 04:17, 27 February 2024

ALPK1
Identifiers
AliasesALPK1, 8430410J10Rik, LAK, alpha kinase 1, ROSAH
External IDsOMIM: 607347; MGI: 1918731; HomoloGene: 11849; GeneCards: ALPK1; OMA:ALPK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

80216

71481

Ensembl

ENSG00000073331

ENSMUSG00000028028

UniProt

Q96QP1

Q9CXB8

RefSeq (mRNA)

NM_001102406
NM_001253884
NM_025144

NM_027808

RefSeq (protein)

NP_001095876
NP_001240813
NP_079420

n/a

Location (UCSC)Chr 4: 112.29 – 112.44 MbChr 3: 127.46 – 127.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-protein kinase 1 is an enzyme that in humans is encoded by the ALPK1 gene.[5][6][7]

Unlike most eukaryotic kinases, alpha kinases, such as LAK, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.[supplied by OMIM][7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073331 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028028 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ryazanov AG, Pavur KS, Dorovkov MV (Mar 1999). "Alpha-kinases: a new class of protein kinases with a novel catalytic domain". Curr Biol. 9 (2): R43–5. Bibcode:1999CBio....9..R43R. doi:10.1016/S0960-9822(99)80006-2. PMID 10021370. S2CID 34505206.
  6. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  7. ^ a b "Entrez Gene: ALPK1 alpha-kinase 1".
[edit]

Further reading

[edit]


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