2-Methyl-1-butanol: Difference between revisions
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{{chembox |
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| verifiedrevid = 407466275 |
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|verifiedrevid = 477213957 |
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| Name = 2-Methyl-1-butanol |
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|Name = 2-Methyl-1-butanol |
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| ImageFile_Ref = {{chemboximage|correct|??}} |
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|ImageFile_Ref = {{chemboximage|correct|??}} |
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| ImageFile = 2-methylbutan-1-ol-2D-skeletal.png |
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|ImageFile = 2-Methyl-1-butanol.svg |
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| ImageSize = |
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|ImageSize = 150px |
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|PIN = 2-Methylbutan-1-ol |
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|OtherNames = 2-Methyl-1-butanol<br />Active amyl alcohol |
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|Reference = <ref name="hand"> |
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{{Citation |
{{Citation |
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|last = Lide |
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|first = David R. |
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|year = 1998 |
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| author-link = |
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|title = Handbook of Chemistry and Physics |
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| last2 = |
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|edition = 87 |
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|publication-place = Boca Raton, Florida |
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| author2-link = |
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|publisher = CRC Press |
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| publication-date = |
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|isbn = 0-8493-0594-2 |
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| date = |
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|pages = 3–374, 5–42, 6–188, 8–102, 16–22 |
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| year = 1998 |
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| title = Handbook of Chemistry and Physics |
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| edition = 87 |
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| volume = |
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| series = |
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| publication-place = Boca Raton, FL |
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| place = |
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| publisher = CRC Press |
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| id = |
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| isbn = 0-8493-0594-2 |
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| doi = |
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| oclc = |
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| pages = 3–374, 5–42, 6–188, 8–102, 16–22 |
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| url = |
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| accessdate = |
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}}</ref><ref name="encyc"> |
}}</ref><ref name="encyc"> |
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{{Citation |
{{Citation |
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|last1 = McKetta |
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|first1 = John J. |
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|last2 = Cunningham |
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| author-link = |
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|first2 = William Aaron |
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| last2 = Cunningham |
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|year = 1977 |
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| first2 = William Aaron |
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|title = Encyclopedia of Chemical Processing and Design |
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| author2-link = |
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|volume = 3 |
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| publication-date = |
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|publication-place = Boca Raton, Florida |
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| date = |
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|publisher = CRC Press |
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| year = 1977 |
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|isbn = 978-0-8247-2480-1 |
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| title = Encyclopedia of Chemical Processing and Design |
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|pages = 279–280 |
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| edition = |
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|url = https://books.google.com/books?id=iwSU5G5VzO0C&pg=PA279 |
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| volume = 3 |
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|access-date = 2009-12-14 |
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| series = |
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| publication-place = Boca Raton, FL |
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| place = |
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| publisher = CRC Press |
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| id = |
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| isbn = 978-0-8247-2480-1 |
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| doi = |
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| oclc = |
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| pages = 279–280 |
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| url = http://books.google.com/?id=iwSU5G5VzO0C&pg=PA279 |
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| accessdate = 2009-12-14 |
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}}</ref> |
}}</ref> |
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|Section1={{Chembox Identifiers |
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|ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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|ChemSpiderID = 8398 |
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|InChI = 1/C5H12O/c1-3-5(2)4-6/h5-6H,3-4H2,1-2H3 |
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|InChIKey = QPRQEDXDYOZYLA-UHFFFAOYAW |
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|ChEBI_Ref = {{ebicite|correct|EBI}} |
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| SMILES = OCC(C)CC |
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|ChEBI = 48945 |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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|UNII_Ref = {{fdacite|correct|FDA}} |
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| ChEMBL = 451923 |
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|UNII = 7VTJ239ASU |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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|SMILES = OCC(C)CC |
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| StdInChI = 1S/C5H12O/c1-3-5(2)4-6/h5-6H,3-4H2,1-2H3 |
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|ChEMBL_Ref = {{ebicite|correct|EBI}} |
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|ChEMBL = 451923 |
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| StdInChIKey = QPRQEDXDYOZYLA-UHFFFAOYSA-N |
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|StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| CASNo = 137-32-6 |
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|StdInChI = 1S/C5H12O/c1-3-5(2)4-6/h5-6H,3-4H2,1-2H3 |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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|StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| RTECS = |
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|StdInChIKey = QPRQEDXDYOZYLA-UHFFFAOYSA-N |
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| EINECS = |
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|CASNo = 137-32-6 |
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| PubChem = 8723 |
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|CASNo_Ref = {{cascite|correct|CAS}} |
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|CASNo1 = 1565-80-6 |
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|CASNo1_Comment = <small>(''S'')</small> |
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|PubChem = 8723 |
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}} |
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|Section2={{Chembox Properties |
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|Formula = C<sub>5</sub>H<sub>12</sub>O |
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|MolarMass = 88.148 g/mol |
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|Appearance = colorless liquid |
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|Density = 0.8152 g/cm<sup>3</sup> |
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|Solubility = 31 g/L |
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|SolubleOther = [[organic solvents]] |
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|MeltingPtC = -117.2 |
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|BoilingPtC = 127.5 |
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|Viscosity = 4.453 mPa·s |
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|VaporPressure = 3 [[mm Hg]] |
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}} |
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|Section3={{Chembox Thermochemistry |
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| DeltaHf = -356.6 [[Kilojoule per mole|kJ·mol<sup>−1</sup>]] (liquid) <br/> -301.4 [[Kilojoule per mole|kJ·mol<sup>−1</sup>]] (gas) |
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}} |
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|Section4={{Chembox Hazards |
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|AutoignitionPtC = 385 |
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}} |
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|Section5={{Chembox Related |
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|OtherCompounds = [[Amyl alcohol]] |
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}} |
}} |
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| Section2 = {{Chembox Properties |
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| Formula = C<sub>5</sub>H<sub>12</sub>O |
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| MolarMass = 88.148 g/mol |
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| Appearance = colorless liquid |
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| Density = 0.8152 g/cm<sup>3</sup> |
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| Solubility = 31 g/L |
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| SolubleOther = [[miscible]] with [[ethanol]], [[diethyl ether]]; very soluble in [[acetone]] |
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| MeltingPtC = -117.2 |
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| BoilingPtC = 127.5 |
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| Viscosity = 4.453 mPa·s |
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| VaporPressure = 3 [[mm Hg]] |
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}} |
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| Section3 = {{Chembox Structure |
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| Coordination = |
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| CrystalStruct = |
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}} |
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| Section4 = {{Chembox Thermochemistry |
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| DeltaHf = -356.6 [[Kilojoule per mole|kJ·mol<sup>-1</sup>]] (liquid) <br/> -301.4 [[Kilojoule per mole|kJ·mol<sup>-1</sup>]] (gas) |
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| DeltaHc = |
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| Entropy = |
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| HeatCapacity = |
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}} |
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| Section7 = {{Chembox Hazards |
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| ExternalMSDS = |
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| EUIndex = |
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| NFPA-H = |
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| NFPA-F = |
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| NFPA-R = |
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| RPhrases = |
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| SPhrases = |
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| FlashPt = 50 °C |
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| Autoignition = 385 °C |
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| ExploLimits = |
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| LD50 = |
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}} |
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| Section8 = {{Chembox Related |
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| OtherCpds = [[Amyl alcohol]] |
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}} |
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}} |
}} |
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'''2-Methyl-1-butanol''' ([[IUPAC]] name, also called '''active amyl alcohol''') is an [[organic compound]] with the formula CH<sub>3</sub>CH<sub>2</sub>CH(CH<sub>3</sub>)CH<sub>2</sub>OH. It is one of several [[isomer]]s of [[amyl alcohol]]. This colorless liquid occurs naturally in trace amounts and has attracted some attention as a potential [[biofuel]], exploiting its hydrophobic (gasoline-like) and branched structure. It is [[chiral]].<ref>{{cite journal |doi=10.1002/1521-3773(20011203)40:23<4422::AID-ANIE4422>3.0.CO;2-G|title=Enantioseparation of Racemic Organic Molecules by a Zeolite Analogue|year=2001|last1=Xiong|first1= Ren-Gen|last2=You|first2=Xiao-Zeng|last3=Abrahams|first3= Brendan F.|last4=Xue|first4=Ziling|last5=Che|first5=Chi-Ming|journal=Angewandte Chemie International Edition|volume=40|issue=23|pages=4422–4425|pmid=12404434}}</ref> |
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'''2-Methyl-1-butanol''' ([[IUPAC]] name, also called '''active amyl alcohol''') is an [[organic chemistry|organic]] [[chemical compound]]. It is used as a [[solvent]] and an intermediate in the manufacture of other chemicals. 2-Methyl-1-butanol is a component of many mixtures of [[amyl alcohol]]s sold industrially. |
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== |
== Occurrence == |
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2-Methyl-1-butanol |
2-Methyl-1-butanol is a component of many mixtures of commercial [[amyl alcohol]]s. |
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{{Citation |
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2M1B also occurs naturally. For example, [[fusel alcohol]]s like 2M1B are grain fermentation byproducts, and therefore trace amounts of 2M1B are present in [[comparison of psychoactive alcohols in alcoholic drinks|many alcoholic beverages]]. Also, it is one of the many components of the aroma of various fungi and fruit, e.g., the summer [[truffle]], tomato,<ref>{{cite journal |doi=10.1021/jf00076a025|title=Fresh tomato aroma volatiles: A quantitative study|year=1987|last1=Buttery|first1=Ron G.|last2=Teranishi|first2=Roy|last3=Ling|first3=Louisa C.|journal=Journal of Agricultural and Food Chemistry|volume=35|issue=4|pages=540–544}}</ref> and [[cantaloupe]].<ref>{{cite journal |doi=10.1016/j.chroma.2003.08.016|title=Truffle Aroma Characterization by Headspace solid-phase microextraction|year=2003|last1=Dı́Az|first1=P.|last2=Ibáñez|first2 =E.|last3=Señoráns|first3=F.J|last4=Reglero|first4=G.|journal=Journal of Chromatography A|volume=1017|issue=1–2|pages=207–214|pmid=14584705}}</ref><ref>{{cite journal |doi=10.1021/jf0005768|title=Identification of Volatile Compounds in Cantaloupe at Various Developmental Stages Using Solid Phase Microextraction|year=2001|last1=Beaulieu|first1=John C.|last2=Grimm|first2=Casey C.|journal=Journal of Agricultural and Food Chemistry|volume=49|issue=3|pages=1345–1352|pmid=11312862}}</ref> |
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| last = Howard |
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| first = Philip H. |
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==Production and reactions == |
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| author-link = |
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2-Methyl-1-butanol has been produced from glucose by genetically modified [[E. coli]]. 2-Keto-3-methylvalerate, a precursor to [[threonine]], is converted to the target alcohol by the sequential action of 2-keto acid [[decarboxylase]] and [[dehydrogenase]].<ref>{{cite journal |doi=10.1038/nature06450|title=Non-Fermentative Pathways for Synthesis of Branched-Chain Higher Alcohols as Biofuels|year=2008|last1=Atsumi|first1=Shota|last2= Hanai|first2=Taizo|last3=Liao|first3=James C.|journal=Nature|volume=451|issue=7174|pages=86–89|pmid=18172501|bibcode=2008Natur.451...86A|s2cid=4413113}}</ref> It can be derived from [[fusel oil]] (because it occurs naturally in [[fruit]]s such as [[grape]]s<ref name="hef"> |
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| last2 = |
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| first2 = |
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| author2-link = |
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| publication-date = |
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| date = |
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| year = 1993 |
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| title = Handbook of Environmental Fate and Exposure Data for Organic Chemicals |
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| edition = |
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| volume = 4 |
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| series = |
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| publication-place = Boca Raton, FL |
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| place = |
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| publisher = CRC Press |
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| id = |
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| isbn = 978-0-87371-413-6 |
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| doi = |
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| oclc = |
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| pages = 392–396 |
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| url = http://books.google.com/?id=HdhohbQrg8IC&pg=PA392 |
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| accessdate = 2009-12-14 |
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}}</ref>) or manufactured by either the [[oxo process]] or via the [[halogenation]] of [[pentane]].<ref name="encyc"> |
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{{Citation |
{{Citation |
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| last = Howard |
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| first = Philip H. |
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| year = 1993 |
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| title = Handbook of Environmental Fate and Exposure Data for Organic Chemicals |
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| last2 = Cunningham |
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| volume = 4 |
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| first2 = William Aaron |
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| publication-place = Boca Raton, Florida |
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| author2-link = |
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| publisher = CRC Press |
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| publication-date = |
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| isbn = 978-0-87371-413-6 |
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| date = |
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| pages = 392–396 |
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| url = https://books.google.com/books?id=HdhohbQrg8IC&pg=PA392 |
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| title = Encyclopedia of Chemical Processing and Design |
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| access-date = 2009-12-14 |
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| edition = |
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}}</ref>) or manufactured by either the [[oxo process]] or via the [[halogenation]] of [[pentane]].<ref name="encyc" /> |
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| volume = 3 |
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| series = |
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| publication-place = Boca Raton, FL |
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| place = |
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| publisher = CRC Press |
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| id = |
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| isbn = 978-0-8247-2480-1 |
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| doi = |
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| oclc = |
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| pages = 279–280 |
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| url = http://books.google.com/?id=iwSU5G5VzO0C&pg=PA279 |
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| accessdate = 2009-12-14 |
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}}</ref> |
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== See also == |
== See also == |
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== References == |
== References == |
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{{Reflist}} |
{{Reflist}} |
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{{Alcohols}} |
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{{DEFAULTSORT:Methyl-1-butanol, 2-}} |
{{DEFAULTSORT:Methyl-1-butanol, 2-}} |
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[[Category:Alcohol solvents]] |
[[Category:Alcohol solvents]] |
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[[Category:Primary alcohols]] |
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[[Category:Alkanols]] |
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[[nl:2-methyl-1-butanol]] |
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[[pt:2-metil-1-butanol]] |
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[[fi:2-metyyli-1-butanoli]] |
Latest revision as of 16:13, 13 March 2024
Names | |
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Preferred IUPAC name
2-Methylbutan-1-ol | |
Other names
2-Methyl-1-butanol
Active amyl alcohol | |
Identifiers | |
3D model (JSmol)
|
|
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.004.809 |
PubChem CID
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|
UNII | |
CompTox Dashboard (EPA)
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|
| |
| |
Properties | |
C5H12O | |
Molar mass | 88.148 g/mol |
Appearance | colorless liquid |
Density | 0.8152 g/cm3 |
Melting point | −117.2 °C (−179.0 °F; 156.0 K) |
Boiling point | 127.5 °C (261.5 °F; 400.6 K) |
31 g/L | |
Solubility | organic solvents |
Vapor pressure | 3 mm Hg |
Viscosity | 4.453 mPa·s |
Thermochemistry | |
Std enthalpy of
formation (ΔfH⦵298) |
-356.6 kJ·mol−1 (liquid) -301.4 kJ·mol−1 (gas) |
Hazards | |
385 °C (725 °F; 658 K) | |
Related compounds | |
Related compounds
|
Amyl alcohol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
2-Methyl-1-butanol (IUPAC name, also called active amyl alcohol) is an organic compound with the formula CH3CH2CH(CH3)CH2OH. It is one of several isomers of amyl alcohol. This colorless liquid occurs naturally in trace amounts and has attracted some attention as a potential biofuel, exploiting its hydrophobic (gasoline-like) and branched structure. It is chiral.[3]
Occurrence
[edit]2-Methyl-1-butanol is a component of many mixtures of commercial amyl alcohols.
2M1B also occurs naturally. For example, fusel alcohols like 2M1B are grain fermentation byproducts, and therefore trace amounts of 2M1B are present in many alcoholic beverages. Also, it is one of the many components of the aroma of various fungi and fruit, e.g., the summer truffle, tomato,[4] and cantaloupe.[5][6]
Production and reactions
[edit]2-Methyl-1-butanol has been produced from glucose by genetically modified E. coli. 2-Keto-3-methylvalerate, a precursor to threonine, is converted to the target alcohol by the sequential action of 2-keto acid decarboxylase and dehydrogenase.[7] It can be derived from fusel oil (because it occurs naturally in fruits such as grapes[8]) or manufactured by either the oxo process or via the halogenation of pentane.[2]
See also
[edit]References
[edit]- ^ Lide, David R. (1998), Handbook of Chemistry and Physics (87 ed.), Boca Raton, Florida: CRC Press, pp. 3–374, 5–42, 6–188, 8–102, 16–22, ISBN 0-8493-0594-2
- ^ a b McKetta, John J.; Cunningham, William Aaron (1977), Encyclopedia of Chemical Processing and Design, vol. 3, Boca Raton, Florida: CRC Press, pp. 279–280, ISBN 978-0-8247-2480-1, retrieved 2009-12-14
- ^ Xiong, Ren-Gen; You, Xiao-Zeng; Abrahams, Brendan F.; Xue, Ziling; Che, Chi-Ming (2001). "Enantioseparation of Racemic Organic Molecules by a Zeolite Analogue". Angewandte Chemie International Edition. 40 (23): 4422–4425. doi:10.1002/1521-3773(20011203)40:23<4422::AID-ANIE4422>3.0.CO;2-G. PMID 12404434.
- ^ Buttery, Ron G.; Teranishi, Roy; Ling, Louisa C. (1987). "Fresh tomato aroma volatiles: A quantitative study". Journal of Agricultural and Food Chemistry. 35 (4): 540–544. doi:10.1021/jf00076a025.
- ^ Dı́Az, P.; Ibáñez, E.; Señoráns, F.J; Reglero, G. (2003). "Truffle Aroma Characterization by Headspace solid-phase microextraction". Journal of Chromatography A. 1017 (1–2): 207–214. doi:10.1016/j.chroma.2003.08.016. PMID 14584705.
- ^ Beaulieu, John C.; Grimm, Casey C. (2001). "Identification of Volatile Compounds in Cantaloupe at Various Developmental Stages Using Solid Phase Microextraction". Journal of Agricultural and Food Chemistry. 49 (3): 1345–1352. doi:10.1021/jf0005768. PMID 11312862.
- ^ Atsumi, Shota; Hanai, Taizo; Liao, James C. (2008). "Non-Fermentative Pathways for Synthesis of Branched-Chain Higher Alcohols as Biofuels". Nature. 451 (7174): 86–89. Bibcode:2008Natur.451...86A. doi:10.1038/nature06450. PMID 18172501. S2CID 4413113.
- ^ Howard, Philip H. (1993), Handbook of Environmental Fate and Exposure Data for Organic Chemicals, vol. 4, Boca Raton, Florida: CRC Press, pp. 392–396, ISBN 978-0-87371-413-6, retrieved 2009-12-14