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In simple words, the cistrome refers a collection of regulatory elements of a set of genes, including transcription factor binding sites and histone modifications. More specifically, "the set of cis-acting targets of a trans-acting factor on a genome-wide scale, also known as the in vivo genome-wide location of transcription factor binding sites or histone modifications".^[1] The term cistrome is a portmanteau of cistr (from cistron) + ome (from genome). The term cistrome was coined by investigators at the Dana–Farber Cancer Institute and Harvard Medical School.^[2]

Technologies such as chromatin immunoprecipitation combined with microarray analysis "ChIP-on-chip" or with massively parallel DNA sequencing "ChIP-Seq" have greatly facilitated the definition of the cistrome of transcription factors and other chromatin associated proteins.

References

^ Liu T, Ortiz JA, Taing L, Meyer CA, Lee B, Zhang Y, Shin H, Wong SS, Ma J, Lei Y, Pape UJ, Poidinger M, Chen Y, Yeung K, Brown M, Turpaz Y, Liu XS (2011). "Cistrome: an integrative platform for transcriptional regulation studies". Genome Biol. 12 (8): R83. doi:10.1186/gb-2011-12-8-r83. PMC 3245621. PMID 21859476.
^ "cistrome / FrontPage". PBWiki, Inc.

Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS, Brown M (March 2008). "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription". Cell. 132 (6): 958–70. doi:10.1016/j.cell.2008.01.018. PMC 2323438. PMID 18358809.
Lupien M, Brown M (June 2009). "Cistromics of hormone-dependent cancer". Endocr. Relat. Cancer. 16 (2): 381–9. doi:10.1677/ERC-09-0038. PMID 19369485.

This genetics article is a stub. You can help Wikipedia by expanding it.

[pmid21859476-1] Liu T, Ortiz JA, Taing L, Meyer CA, Lee B, Zhang Y, Shin H, Wong SS, Ma J, Lei Y, Pape UJ, Poidinger M, Chen Y, Yeung K, Brown M, Turpaz Y, Liu XS (2011). "Cistrome: an integrative platform for transcriptional regulation studies". Genome Biol. 12 (8): R83. doi:10.1186/gb-2011-12-8-r83. PMC 3245621. PMID 21859476.

[urlcistrome_/_FrontPage-2] "cistrome / FrontPage". PBWiki, Inc.

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+In simple words, the '''cistrome''' refers a collection of [[regulatory element]]s of a set of genes, including transcription factor binding sites and histone modifications. More specifically, "the set of [[cis-acting]] targets of a [[trans-acting]] factor on a genome-wide scale, also known as the ''in vivo'' genome-wide location of [[transcription factor]] [[binding site]]s or [[histone]] modifications".<ref name="pmid21859476">{{cite journal | vauthors = Liu T, Ortiz JA, Taing L, Meyer CA, Lee B, Zhang Y, Shin H, Wong SS, Ma J, Lei Y, Pape UJ, Poidinger M, Chen Y, Yeung K, Brown M, Turpaz Y, Liu XS | title = Cistrome: an integrative platform for transcriptional regulation studies | journal = Genome Biol. | volume = 12 | issue = 8 | pages = R83 | year = 2011 | pmid = 21859476 | pmc = 3245621 | doi = 10.1186/gb-2011-12-8-r83 | doi-access = free }}</ref> The term cistrome is a [[portmanteau]] of '''{{langr|mis|cistr}}''' (from [[cistron]]) + '''ome''' (from [[genome]]). The term cistrome was coined by investigators at the [[Dana–Farber Cancer Institute]] and [[Harvard Medical School]].<ref name="urlcistrome / FrontPage">{{cite web | url = http://cistrome.pbworks.com/enwiki/w/page/10521472/FrontPage | title = cistrome / FrontPage | publisher = PBWiki, Inc. }}</ref>
+Technologies such as [[chromatin immunoprecipitation]] combined with microarray analysis "[[ChIP-on-chip]]" or with massively parallel DNA sequencing "[[ChIP-Seq]]" have greatly facilitated the definition of the cistrome of [[transcription factors]] and other [[chromatin]] associated proteins.
-'''Cistrome'''
-This term http://cistrome.pbwiki.com was coined by investigators at the [[Dana-Farber Cancer Institute]] and [[Harvard Medical School]] to define the set of ''cis''-acting targets ([[DNA binding site]]s) of a ''trans''-acting factor ([[transcription factor]], pioneer factor, [[restriction enzyme]], etc) on a ''[[genome]]'' scale. Technologies such as [[chromatin immunoprecipitation]] combined with microarray "[[ChIP-on-chip]]" or with massively parallel DNA sequencing "[[ChIP-Seq|ChIP-Seq]]" have greatly facilitated the definition of the cistrome of [[transcription factors]] and other [[chromatin]] associated proteins.
-==References==
+== References ==
+{{Reflist}}
-* http://www.dana-farber.org/abo/news/press/2006/molecular-atlas-provides-new-tool-for-understanding-estrogen-fueled-breast-cancer.html
-http://www.cell.com/content/article/abstract?uid=PIIS0092867408001189
+== Further reading ==
-http://erc.endocrinology-journals.org/cgi/content/full/16/2/381
+{{refbegin}}
+* {{cite journal | vauthors = Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS, Brown M | title = FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription | journal = Cell | volume = 132 | issue = 6 | pages = 958–70 |date=March 2008 | pmid = 18358809 | pmc = 2323438 | doi = 10.1016/j.cell.2008.01.018 }}
+* {{cite journal | vauthors = Lupien M, Brown M | title = Cistromics of hormone-dependent cancer | journal = Endocr. Relat. Cancer | volume = 16 | issue = 2 | pages = 381–9 |date=June 2009 | pmid = 19369485 | doi = 10.1677/ERC-09-0038 | doi-access = free }}
+{{refend}}
-{{genetics-stub}}
 [[Category:Molecular genetics]]
-[[fr:Cistrome]]
+{{genetics-stub}}