PABPC3: Difference between revisions

PABPC3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4IVE
Identifiers
Aliases	PABPC3, PABP3, PABPL3, tPABP, poly(A) binding protein cytoplasmic 3
External IDs	OMIM: 604680; HomoloGene: 118007; GeneCards: PABPC3; OMA:PABPC3 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	25,099,254 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; epithelium of nasopharynx; ; amniotic fluid; ; pancreatic ductal cell; ; seminal vesicula; ; pylorus; ; lactiferous duct; ; buccal mucosa cell; ; oral cavity; ; vulva;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	poly(A) binding; RNA binding; nucleic acid binding; mRNA 3'-UTR binding; poly(U) RNA binding;
Cellular component	cytoplasm; extracellular exosome; cytosol; nucleus; cytoplasmic stress granule; ribonucleoprotein complex;
Biological process	mRNA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5042
	n/a
	ENSG00000151846
	n/a
	Q9H361
	n/a
	NM_030979
	n/a
	NP_112241
	n/a
	Wikidata
View/Edit Human

Browse history interactively

← Previous edit

Content deleted Content added

VisualWikitext

Inline

Latest revision as of 10:52, 11 April 2024

Polyadenylate-binding protein 3 is a protein that in humans is encoded by the PABPC3 gene.^[3]^[4]^[5] PABPC3 is a member of a larger family of poly(A)-binding proteins in the human genome.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151846 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Morris CM, Bodger MP (Mar 1993). "Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization". Genomics. 15 (1): 209–11. doi:10.1006/geno.1993.1037. PMID 8432538.
^ Feral C, Mattei MG, Pawlak A, Guellaen G (Nov 1999). "Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes". Hum Genet. 105 (4): 347–53. doi:10.1007/s004399900148. PMC 1865476. PMID 10543404.
^ "Entrez Gene: PABPC3 poly(A) binding protein, cytoplasmic 3".

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Polyadenylate-binding protein 3 (PABPC3)

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151846 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8432538-3] Morris CM, Bodger MP (Mar 1993). "Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization". Genomics. 15 (1): 209–11. doi:10.1006/geno.1993.1037. PMID 8432538.

[pmid10543404-4] Feral C, Mattei MG, Pawlak A, Guellaen G (Nov 1999). "Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes". Hum Genet. 105 (4): 347–53. doi:10.1007/s004399900148. PMC 1865476. PMID 10543404.

[entrez-5] "Entrez Gene: PABPC3 poly(A) binding protein, cytoplasmic 3".

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=5042}}
+{{cs1 config|name-list-style=vanc}}
-'''Polyadenylate-binding protein 3''' is a [[protein]] that in humans is encoded by the ''PABPC3'' [[gene]].<ref name="pmid8432538">{{cite journal | author = Morris CM, Bodger MP | title = Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization | journal = Genomics | volume = 15 | issue = 1 | pages = 209–11 | year = 1993 | month = Mar | pmid = 8432538 | pmc =  | doi = 10.1006/geno.1993.1037 }}</ref><ref name="pmid10543404">{{cite journal | author = Feral C, Mattei MG, Pawlak A, Guellaen G | title = Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes | journal = Hum Genet | volume = 105 | issue = 4 | pages = 347–53 | year = 1999 | month = Nov | pmid = 10543404 | pmc = 1865476 | doi =10.1007/s004390051113  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PABPC3 poly(A) binding protein, cytoplasmic 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5042| accessdate = }}</ref>
+{{Infobox_gene}}
+'''Polyadenylate-binding protein 3''' is a [[protein]] that in humans is encoded by the ''PABPC3'' [[gene]].<ref name="pmid8432538">{{cite journal | vauthors = Morris CM, Bodger MP | title = Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization | journal = Genomics | volume = 15 | issue = 1 | pages = 209–11 |date=Mar 1993 | pmid = 8432538 | doi = 10.1006/geno.1993.1037 }}</ref><ref name="pmid10543404">{{cite journal | vauthors = Feral C, Mattei MG, Pawlak A, Guellaen G | title = Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes | journal = Hum Genet | volume = 105 | issue = 4 | pages = 347–53 |date=Nov 1999 | pmid = 10543404 | pmc = 1865476 | doi =10.1007/s004399900148  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PABPC3 poly(A) binding protein, cytoplasmic 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5042}}</ref> PABPC3 is a member of a larger family of [[poly(A)-binding protein]]s in the human genome.
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PABPC3 poly(A) binding protein, cytoplasmic 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5042| accessdate = }}</ref>
-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+* {{cite journal   |vauthors=Marques AC, Dupanloup I, Vinckenbosch N, etal |title=Emergence of young human genes after a burst of retroposition in primates. |journal=PLOS Biol. |volume=3 |issue= 11 |pages= e357 |year= 2006 |pmid= 16201836 |doi= 10.1371/journal.pbio.0030357  | pmc=1251493 |doi-access=free }}
-{{PBB_Further_reading
+* {{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-| citations =
-*{{cite journal  | author=Marques AC, Dupanloup I, Vinckenbosch N, ''et al.'' |title=Emergence of young human genes after a burst of retroposition in primates. |journal=PLoS Biol. |volume=3 |issue= 11 |pages= e357 |year= 2006 |pmid= 16201836 |doi= 10.1371/journal.pbio.0030357  | pmc=1251493 }}
+* {{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
+* {{cite journal  | vauthors=Féral C, Guellaën G, Pawlak A |title=Human testis expresses a specific poly(A)-binding protein. |journal=Nucleic Acids Res. |volume=29 |issue= 9 |pages= 1872–83 |year= 2002 |pmid= 11328870 |doi=10.1093/nar/29.9.1872  | pmc=37253  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+* {{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
-*{{cite journal  | author=Féral C, Guellaën G, Pawlak A |title=Human testis expresses a specific poly(A)-binding protein. |journal=Nucleic Acids Res. |volume=29 |issue= 9 |pages= 1872–83 |year= 2002 |pmid= 11328870 |doi=10.1093/nar/29.9.1872  | pmc=37253  }}
+* {{cite journal   |vauthors=Hoshino S, Imai M, Kobayashi T, etal |title=The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16677–80 |year= 1999 |pmid= 10358005 |doi=10.1074/jbc.274.24.16677  |doi-access=free }}
-*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
-*{{cite journal  | author=Hoshino S, Imai M, Kobayashi T, ''et al.'' |title=The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16677–80 |year= 1999 |pmid= 10358005 |doi=10.1074/jbc.274.24.16677  }}
-}}
 {{refend}}
+== External links ==
+* [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q9H361 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Polyadenylate-binding protein 3 (PABPC3)
 {{PDB Gallery|geneid=5042}}
+{{RNA-binding proteins}}
-{{gene-13-stub}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{gene-13-stub}}
-{{PBB_Controls
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}