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{{Short description|Group of cytochrome P450 enzymes}} |
{{Short description|Group of cytochrome P450 enzymes}} |
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'''Cytochrome P450, family 76''', also known as '''CYP76''', is a [[cytochrome P450]] [[protein family|family]] in land [[plant]],<ref name=eggplant/><ref name=pmid23933465/> related to the [[biosynthesis]] of many plant [[monoterpenes]] and [[diterpenes]] such as [[8-hydroxygeraniol]],<ref>{{cite journal | vauthors = Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, Memelink J | title = Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis | journal = FEBS Letters | volume = 508 | issue = 2 | pages = 215–20 | date = November 2001 | pmid = 11718718 | doi = 10.1016/s0014-5793(01)03045-9 | s2cid = 45615763 | doi-access = free }}</ref><ref name=pmid23933465>{{cite journal |last1=Höfer |first1=R |last2=Dong |first2=L |last3=André |first3=F |last4=Ginglinger |first4=JF |last5=Lugan |first5=R |last6=Gavira |first6=C |last7=Grec |first7=S |last8=Lang |first8=G |last9=Memelink |first9=J |last10=Van der Krol |first10=S |last11=Bouwmeester |first11=H |last12=Werck-Reichhart |first12=D |title=Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway. |journal=Metabolic |
'''Cytochrome P450, family 76''', also known as '''CYP76''', is a [[cytochrome P450]] [[protein family|family]] in land [[plant]]s,<ref name=eggplant/><ref name=pmid23933465/> related to the [[biosynthesis]] of many plant [[monoterpenes]] and [[diterpenes]] such as [[8-hydroxygeraniol]],<ref>{{cite journal | vauthors = Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, Memelink J | title = Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis | journal = FEBS Letters | volume = 508 | issue = 2 | pages = 215–20 | date = November 2001 | pmid = 11718718 | doi = 10.1016/s0014-5793(01)03045-9 | s2cid = 45615763 | doi-access = free }}</ref><ref name=pmid23933465>{{cite journal |last1=Höfer |first1=R |last2=Dong |first2=L |last3=André |first3=F |last4=Ginglinger |first4=JF |last5=Lugan |first5=R |last6=Gavira |first6=C |last7=Grec |first7=S |last8=Lang |first8=G |last9=Memelink |first9=J |last10=Van der Krol |first10=S |last11=Bouwmeester |first11=H |last12=Werck-Reichhart |first12=D |title=Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway. |journal=Metabolic Engineering |date=November 2013 |volume=20 |pages=221–32 |doi=10.1016/j.ymben.2013.08.001 |pmid=23933465}}</ref> [[tanshinone]] and [[alkannin]].<ref>{{cite journal |last1=Höfer |first1=R |last2=Boachon |first2=B |last3=Renault |first3=H |last4=Gavira |first4=C |last5=Miesch |first5=L |last6=Iglesias |first6=J |last7=Ginglinger |first7=JF |last8=Allouche |first8=L |last9=Miesch |first9=M |last10=Grec |first10=S |last11=Larbat |first11=R |last12=Werck-Reichhart |first12=D |title=Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides. |journal=Plant Physiology |date=November 2014 |volume=166 |issue=3 |pages=1149–61 |doi=10.1104/pp.114.244814 |pmid=25082892|pmc=4226383 }}</ref><ref>{{cite journal |last1=Bathe |first1=Ulschan |last2=Frolov |first2=Andrej |last3=Porzel |first3=Andrea |last4=Tissier |first4=Alain |title=CYP76 Oxidation Network of Abietane Diterpenes in Lamiaceae Reconstituted in Yeast |journal=Journal of Agricultural and Food Chemistry |date=11 December 2019 |volume=67 |issue=49 |pages=13437–13450 |doi=10.1021/ACS.JAFC.9B00714|pmid=30994346 }}</ref> The first gene identified in this family is the '''CYP76A1''' and '''CYP76A2''' from the [[eggplant]].<ref name=eggplant>{{cite journal |last1=Toguri |first1=T |last2=Kobayashi |first2=O |last3=Umemoto |first3=N |title=The cloning of eggplant seedling cDNAs encoding proteins from a novel cytochrome P-450 family (CYP76). |journal=Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression |date=19 October 1993 |volume=1216 |issue=1 |pages=165–9 |doi=10.1016/0167-4781(93)90058-l |pmid=8218411}}</ref> |
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== References == |
== References == |
Latest revision as of 23:21, 13 May 2024
Cytochrome P450, family 76, also known as CYP76, is a cytochrome P450 family in land plants,[1][2] related to the biosynthesis of many plant monoterpenes and diterpenes such as 8-hydroxygeraniol,[3][2] tanshinone and alkannin.[4][5] The first gene identified in this family is the CYP76A1 and CYP76A2 from the eggplant.[1]
References
[edit]- ^ a b Toguri, T; Kobayashi, O; Umemoto, N (19 October 1993). "The cloning of eggplant seedling cDNAs encoding proteins from a novel cytochrome P-450 family (CYP76)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1216 (1): 165–9. doi:10.1016/0167-4781(93)90058-l. PMID 8218411.
- ^ a b Höfer, R; Dong, L; André, F; Ginglinger, JF; Lugan, R; Gavira, C; Grec, S; Lang, G; Memelink, J; Van der Krol, S; Bouwmeester, H; Werck-Reichhart, D (November 2013). "Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway". Metabolic Engineering. 20: 221–32. doi:10.1016/j.ymben.2013.08.001. PMID 23933465.
- ^ Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, Memelink J (November 2001). "Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis". FEBS Letters. 508 (2): 215–20. doi:10.1016/s0014-5793(01)03045-9. PMID 11718718. S2CID 45615763.
- ^ Höfer, R; Boachon, B; Renault, H; Gavira, C; Miesch, L; Iglesias, J; Ginglinger, JF; Allouche, L; Miesch, M; Grec, S; Larbat, R; Werck-Reichhart, D (November 2014). "Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides". Plant Physiology. 166 (3): 1149–61. doi:10.1104/pp.114.244814. PMC 4226383. PMID 25082892.
- ^ Bathe, Ulschan; Frolov, Andrej; Porzel, Andrea; Tissier, Alain (11 December 2019). "CYP76 Oxidation Network of Abietane Diterpenes in Lamiaceae Reconstituted in Yeast". Journal of Agricultural and Food Chemistry. 67 (49): 13437–13450. doi:10.1021/ACS.JAFC.9B00714. PMID 30994346.