Jump to content

Aeromonas hydrophila: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous edit
Content deleted Content added
VisualWikitext
remove predatory open access journal
Citation bot (talk | contribs)
Bots
5,357,772 edits
Added bibcode. | Use this bot. Report bugs. | Suggested by Abductive | Category:Bacterial diseases of fish | #UCB_Category 19/20
 
(34 intermediate revisions by 25 users not shown)
Line 1: Line 1:
{{Short description|Species of heterotrophic, Gram-negative, bacterium}}
{{italic title}}
{{Speciesbox
{{Taxobox
| name = ''Aeromonas hydrophila''
| image=Aeromonas hydrophila.jpg
| image = Aeromonas hydrophila.jpg
| taxon=Aeromonas hydrophila
⚫
| authority=(Chester, 1901) <br/> Stanier, 1943
| domain = [[Bacteria]]
⚫
| synonyms=''Bacillus hydrophilus fuscus'' <small>Sanarelli 1871</small> <br/> ''Bacillus hydrophilus'' <small>Chester 1901</small> <br/> ''Proteus hydrophilus'' <small>(Chester 1901) Bergey et al. 1923</small> <br/> ''Bacterium hydrophilum'' <small>(Chester 1901) Weldin and Levine 1923</small> <br/> ''Pseudomonas hydrophila'' <small>(Chester 1901) Breed et al. 1948</small>
| phylum = [[Proteobacteria]]
| classis = [[Gammaproteobacteria]]
| ordo = [[Aeromonadales]]
| familia = [[Aeromonadaceae]]
| genus = ''[[Aeromonas]]''
| species = '''''A. hydrophila'''''
| binomial = ''Aeromonas hydrophila''
⚫
| binomial_authority = (Chester, 1901) <br> Stanier, 1943
⚫
| synonyms = ''Bacillus hydrophilus fuscus'' <small>Sanarelli 1871</small> <br> ''Bacillus hydrophilus'' <small>Chester 1901</small> <br> ''Proteus hydrophilus'' <small>(Chester 1901) Bergey et al. 1923</small> <br> ''Bacterium hydrophilum'' <small>(Chester 1901) Weldin and Levine 1923</small> <br> ''Pseudomonas hydrophila'' <small>(Chester 1901) Breed et al. 1948</small>
}}
}}
[[Image:Aeromonas hydrophila colonies 01.jpg|thumb|226px|''Aeromonas hydrophila'' colonies on the blood agar.]]
[[Image:Aeromonas hydrophila colonies 01.jpg|thumb|226px|''Aeromonas hydrophila'' colonies on the blood agar.]]


'''''Aeromonas hydrophila''''' is a [[heterotrophic]], [[Gram-negative]], rod-shaped bacterium mainly found in areas with a warm climate. This bacterium can be found in fresh or brackish water. It can survive in [[Wikt:aerobic|aerobic]] and [[Hypoxia (environmental)|anaerobic]] environments, and can digest materials such as [[gelatin]] and [[hemoglobin]]. ''A. hydrophila'' was isolated from humans and animals in the 1950s. It is the most well known of the species of ''[[Aeromonas]]''. It is resistant to most common antibiotics and cold temperatures and is oxidase- and indole-positive.
'''''Aeromonas hydrophila''''' is a [[heterotrophic]], [[Gram-negative]], rod-shaped bacterium mainly found in areas with a warm climate. This bacterium can be found in fresh or brackish water. It can survive in [[Wikt:aerobic|aerobic]] and [[Hypoxia (environmental)|anaerobic]] environments, and can digest materials such as [[gelatin]] and [[hemoglobin]]. ''A. hydrophila'' was isolated from humans and animals in the 1950s. It is the best known of the species of ''[[Aeromonas]]''. It is resistant to most common antibiotics and cold temperatures and is oxidase- and indole-positive. ''Aeromonas hydrophila'' also has a [[symbiotic]] relationship as gut flora inside of certain leeches, such as ''[[Hirudo medicinalis]]''.<ref>{{cite book | vauthors = Sawyer RT | chapter = Leech Biology and Behaviour | volume = II | title = Feeding, Biology. Ecology and Systematic. | publisher = Clarendon Press | location = Oxford | date = 1986 |url=http://www.biopharm-leeches.com/uploads/1/2/6/2/12624111/bioandbehav.pdf | via = Biopharm Leeches |access-date=18 August 2020}}</ref>


==Structure==
== Structure ==
''A. hydrophila'' bacteria are Gram-negative, straight rods with rounded ends (bacilli to coccibacilli shape) usually from 0.3 to 1.0 μm in width, and 1.0 to 3.0 μm in length. They can grow at temperatures as low as 4&nbsp;°C. These bacteria are motile by a polar [[flagellum]].
''Aeromonas hydrophila'' bacteria are Gram-negative, straight rods with rounded ends (bacilli to coccibacilli shape) usually from 0.3 to 1.0 μm in width and 1.0 to 3.0 μm in length. They can grow at temperatures as low as 4&nbsp;°C. These bacteria are motile by a polar [[flagellum]].


==Pathology==
==Pathology==
Because of its structure, it is very toxic to many organisms. When it enters the body of its victim, it travels through the bloodstream to the first available organ. It produces [[aerolysin]] cytotoxic enterotoxin that can cause tissue damage. ''A. hydrophila, [[Aeromonas caviae|A. caviae]],'' and ''[[Aeromonas sobria|A. sobria]]'' are all considered to be opportunistic pathogens, meaning they rarely infect healthy individuals. ''A. hydrophila'' is widely considered a major fish and amphibian pathogen,<ref name="hazen et al 1978">[http://aem.asm.org/cgi/content/abstract/36/5/731 Prevalence and distribution of ''Aeromonas hydrophila'' in the United States]</ref> and its pathogenicity in humans has been recognized for decades.<ref name="Agger et al 1985">[http://jcm.asm.org/cgi/content/abstract/21/6/909 Clinical and microbiological features of Aeromonas hydrophila-associated diarrhea]</ref> The genomic insights of aeromonads could be a stepping stone into understanding of them<ref>{{cite journal|last1=Tan|first1=Wen-Si|last2=Yin|first2=Wai-Fong|last3=Chan|first3=Kok-Gan|title=Insights into the Quorum-Sensing Activity in Aeromonas hydrophila Strain M013 as Revealed by Whole-Genome Sequencing|journal=Genome Announcements|date=2 Jan 2015|volume=3|issue=1|pages=1–2|doi=10.1128/genomeA.01372-14|pmc=4293626}}</ref>
Because of its structure, it is very toxic to many organisms. When it enters the body of its victim, it travels through the bloodstream to the first available organ. It produces [[aerolysin]], a cytotoxic enterotoxin that can cause tissue damage. ''A. hydrophila'', ''[[Aeromonas caviae|A. caviae]]'', and ''[[Aeromonas sobria|A. sobria]]'' are all considered to be opportunistic pathogens, meaning they rarely infect healthy individuals. ''A. hydrophila'' is widely considered a major fish and amphibian pathogen,<ref name="Hazen_1978">{{cite journal | vauthors = Hazen TC, Fliermans CB, Hirsch RP, Esch GW | title = Prevalence and distribution of Aeromonas hydrophila in the United States | journal = Applied and Environmental Microbiology | volume = 36 | issue = 5 | pages = 731–8 | date = November 1978 | pmid = 31839 | pmc = 243130 | doi = 10.1128/aem.36.5.731-738.1978 | bibcode = 1978ApEnM..36..731H }}</ref> and its pathogenicity in humans has been recognized for decades.<ref name="Agger_1985">{{cite journal | vauthors = Agger WA, McCormick JD, Gurwith MJ | title = Clinical and microbiological features of Aeromonas hydrophila-associated diarrhea | journal = Journal of Clinical Microbiology | volume = 21 | issue = 6 | pages = 909–13 | date = June 1985 | pmid = 4008621 | pmc = 271816 | doi = 10.1128/jcm.21.6.909-913.1985 }}</ref> The genomic insights of aeromonas could be a stepping stone into understanding of them<ref>{{cite journal | vauthors = Tan WS, Yin WF, Chan KG | title = Insights into the Quorum-Sensing Activity in Aeromonas hydrophila Strain M013 as Revealed by Whole-Genome Sequencing | journal = Genome Announcements | volume = 3 | issue = 1 | pages = 1–2 | date = January 2015 | pmid = 25555739 | pmc = 4293626 | doi = 10.1128/genomeA.01372-14 }}</ref>


==Pathogenic mechanism==
==Pathogenic mechanism==
The pathogenicity of ''Aeromonas'' species was believed to be mediated by a number of extracellular proteins such as aerolysin, lipase, chitinase, amylase, gelatinase, hemolysins, and enterotoxins. However, the pathogenic mechanisms are unknown. The recently proposed type-III secretion system (TTSS) has been linked to ''Aeromonas'' pathogenesis. TTSS is a specialized protein secretion machinery that exports virulence factors directly to host cells. These factors subvert normal host cell functions to the benefit of invading bacteria. In contrast to the general secretory pathway, the TTSS is triggered when a pathogen comes in contact with host cells. ADP-ribosylation toxin is one of the effector molecules secreted by several pathogenic bacteria and translocated through the TTSS and delivered into the host cytoplasm, which leads to interruption of the NF-κB pathway, cytoskeletal damage, and apoptosis. This toxin has been characterized in ''A. hydrophila'' (human diarrhoeal isolate), ''A. salmonicida'' (fish pathogen), and ''A. jandaei'' GV17, a pathogenic strain which can cause disease both in humans and fish.
The pathogenicity of ''Aeromonas'' species was believed to be mediated by a number of extracellular proteins such as aerolysin, lipase, chitinase, amylase, gelatinase, hemolysins, and enterotoxins. However, the pathogenic mechanisms are unknown. The recently proposed type-III secretion system (T3SS) has been linked to ''Aeromonas'' pathogenesis. T3SS is a specialized protein secretion machinery that exports virulence factors directly to host cells. These factors subvert normal host cell functions to the benefit of invading bacteria. In contrast to the general secretory pathway, the T3SS is triggered when a pathogen comes in contact with host cells. ADP-ribosylation toxin is one of the effector molecules secreted by several pathogenic bacteria and translocated through the T3SS and delivered into the host cytoplasm, which leads to interruption of the NF-κB pathway, cytoskeletal damage, and apoptosis. This toxin has been characterized in ''A. hydrophila'' (human diarrhoeal isolate), ''A. salmonicida'' (fish pathogen), and ''A. jandaei'' GV17, a pathogenic strain that can cause disease both in humans and fish.


===Occurrence of exposure===
==Occurrence of exposure==
''A. hydrophila'' infections occur most often during sexual changes, [[stressor]]s, changes in temperature, in contaminated environments, and when an organism is already infected with a virus or another bacterium. It can also be ingested through food products contaminated with the bacterium, such as seafood, meats, and even certain vegetables such as sprouts. It can also be transmitted by leeches.<ref>{{cite journal | pmc = 267578 | pmid=2666448 | volume=27 | title=Aeromonas hydrophila infection associated with the use of medicinal leeches | year=1989 | journal=J. Clin. Microbiol. | pages=1421–2 | last1 = Snower | first1 = DP | last2 = Ruef | first2 = C | last3 = Kuritza | first3 = AP | last4 = Edberg | first4 = SC}}</ref>
''Aeromonas hydrophila'' infections occur most often during sexual changes, [[stressor]]s, changes in temperature, in contaminated environments, and when an organism is already infected with a virus or another bacterium. It can also be ingested through food products contaminated with the bacterium, such as seafood, meats, and even certain vegetables such as sprouts. It can also be transmitted by leeches.<ref>{{cite journal | vauthors = Snower DP, Ruef C, Kuritza AP, Edberg SC | title = Aeromonas hydrophila infection associated with the use of medicinal leeches | journal = Journal of Clinical Microbiology | volume = 27 | issue = 6 | pages = 1421–2 | date = June 1989 | pmid = 2666448 | pmc = 267578 | doi = 10.1128/jcm.27.6.1421-1422.1989 }}</ref>


===Fish and amphibians===
==Fish and amphibians==
''A. hydrophila'' is associated with diseases mainly found in freshwater fish and [[amphibians]], because these organisms live in aquatic environments. It is linked to a disease found in frogs called red leg, which causes internal, sometimes fatal hemorrhaging. When infected with ''A. hydrophila'', fish develop [[Ulcer (dermatology)|ulcers]], [[tail rot]], [[fin rot]], and [[hemorrhagic septicemia]]. Hemorrhagic septicaemia causes lesions that lead to scale shedding, hemorrhages in the gills and anal area, ulcers, [[exophthalmia]], and abdominal swelling.
''Aeromonas hydrophila'' is associated with diseases mainly found in freshwater fish and [[amphibians]], because these organisms live in aquatic environments. It is linked to a disease found in frogs called red leg, which causes internal, sometimes fatal hemorrhaging. When infected with ''A. hydrophila'', fish develop [[Ulcer (dermatology)|ulcers]], [[tail rot]], [[fin rot]], and [[hemorrhagic septicemia]]. Hemorrhagic septicaemia causes lesions that lead to scale shedding, hemorrhages in the gills and anal area, ulcers, [[exophthalmia]], and abdominal swelling.


===Human diseases===
==Human diseases==
''A. hydrophila'' is not as pathogenic to humans as it is to fish and amphibians. One of the diseases it can cause in humans, [[gastroenteritis]], occurs mostly in young children and people who have compromised immune systems or growth problems. This bacterium is linked to two types of gastroenteritis. The first type is a disease similar to [[cholera]], which causes rice-water diarrhea. The other type is dysenteric gastroenteritis, which causes loose [[human feces|stools]] filled with blood and mucus. Dysenteric gastroenteritis is the most severe out of the two types, and can last for several weeks. ''A. hydrophila'' is also associated with [[cellulitis]]. It also causes diseases such as [[myonecrosis]] and [[eczema]] in people with compromised or suppressed (by medication) immune systems.<ref name="Janda and Abbot 1998">[http://cid.oxfordjournals.org/content/27/2/332.full.pdf Evolving concepts regarding the genus Aeromonas: an expanding panorama of species, disease presentations, and unanswered questions]</ref> In very rare cases, ''A. hydrophila'' can cause [[necrotizing fasciitis]].<ref name="Minnaganti, et al, 2000">[http://www.heartandlung.org/article/S0147-9563(00)43305-4/abstract Necrotizing fasciitis caused by Aeromonas hydrophila]</ref>
''Aeromonas hydrophila'' is not as pathogenic to humans as it is to fish and amphibians. One of the diseases it can cause in humans, [[gastroenteritis]], occurs mostly in young children and people who have compromised immune systems or growth problems. This bacterium is linked to two types of gastroenteritis. The first type is a disease similar to [[cholera]], which causes rice-water diarrhea. The other type is dysenteric gastroenteritis, which causes loose [[human feces|stools]] filled with blood and mucus. Dysenteric gastroenteritis is the most severe out of the two types and can last for several weeks. ''A. hydrophila'' is also associated with [[cellulitis]].<ref>{{cite web |url=https://www.lecturio.com/concepts/cellulitis/| title=Cellulitis|website=The Lecturio Medical Concept Library |access-date= 7 July 2021}}</ref> It also causes diseases such as [[myonecrosis]] and [[eczema]] in people with compromised or suppressed (by medication) immune systems.<ref name="Janda_1998">{{cite journal | vauthors = Janda JM, Abbott SL | title = Evolving concepts regarding the genus Aeromonas: an expanding Panorama of species, disease presentations, and unanswered questions | journal = Clinical Infectious Diseases | volume = 27 | issue = 2 | pages = 332–44 | date = August 1998 | pmid = 9709884 | doi = 10.1086/514652 | doi-access = free }}</ref> In very rare cases, ''A. hydrophila'' can cause [[necrotizing fasciitis]].<ref name="Minnaganti_2000">{{cite journal | vauthors = Minnaganti VR, Patel PJ, Iancu D, Schoch PE, Cunha BA | title = Necrotizing fasciitis caused by Aeromonas hydrophila | journal = Heart & Lung | volume = 29 | issue = 4 | pages = 306–8 | date = 2000 | pmid = 10900069 | doi = 10.1067/mhl.2000.106723 | doi-access = free }}</ref>


===Outbreaks===
==Outbreaks==
Though ''A. hydrophila'' can cause serious disease, large scale outbreaks have not been reported. Outbreaks among vertebrates have occurred. One such incident occurred in Puerto Rico inside the intestinal tracts of lizards.<ref>Fulton, MacDonald. [http://www.uprm.edu/publications/cjs/VOL05/P099-102.PDF "The Bacterium ''Aeromonas hydrophila'' from Lizards of the genus ''Anolis'' in Puerto Rico".] {{webarchive |url=https://web.archive.org/web/20041031023308/http://www.uprm.edu/publications/cjs/VOL05/P099-102.PDF |date=October 31, 2004 }} Louisiana State University Medical Center, New Orleans.</ref> Some 116 different strains were found in the lizards. On May 1, 1988, a small outbreak happened in California. The 225 isolates in 219 patients caused their hospital admissions. Confidential morbidity report cards were used to report the cases to the local health departments. Investigations were conducted, and reports were sent to the California Department of Health Services for diagnosis and methods in treatment.
Though ''A. hydrophila'' can cause serious disease, large scale outbreaks have not been reported. Outbreaks among vertebrates have occurred. One such incident occurred in Puerto Rico inside the intestinal tracts of lizards.<ref>{{cite journal | vauthors = Fulton MA | title = The bacterium Aeromonas hydriphila from lizards of the genus Anolis in Puerto Rico. | journal = Carib. Jour. Sci. | date = 1965 | volume = 2 | pages = 105–7 | url = http://www.uprm.edu/publications/cjs/VOL05/P099-102.PDF | archive-url = https://web.archive.org/web/20041031023308/http://www.uprm.edu/publications/cjs/VOL05/P099-102.PDF | archive-date=October 31, 2004 }}</ref> Some 116 different strains were found in the lizards. On May 1, 1988, a small outbreak happened in California. The 225 isolates in 219 patients caused their hospital admissions. Confidential morbidity report cards were used to report the cases to the local health departments. Investigations were conducted, and reports were sent to the California Department of Health Services for diagnosis and methods in treatment.


===Treatments===
==Treatments==
''Aeromonas hydrophila'' can be eliminated using a 1% [[sodium hypochlorite]] solution or 2% [[calcium hypochlorite]] solution. Brage et al., 1990 recommends fluoroquinolone administration as prophylactic treatment during medicinal leech application.<ref name="pmid2352221">{{cite journal | vauthors = Braga A, Lineaweaver WC, Whitney TM, Follansbee S, Buncke HJ | title = Sensitivities of Aeromonas hydrophila cultured from medicinal leeches to oral antibiotics | journal = Journal of Reconstructive Microsurgery | volume = 6 | issue = 2 | pages = 135–7 | date = April 1990 | pmid = 2352221 | doi = 10.1055/s-2007-1006813 }}</ref> [[Antibiotic]]s such as [[chloramphenicol]], [[florfenicol]], [[tetracycline]], [[sulfonamide (medicine)|sulfonamide]], [[nitrofuran]] derivatives, and [[Pyridinecarboxylic acids]] are used to eliminate and control the infection of ''A. hydrophila''. [[Terramycin]] is placed in fish food during hatchery operations as another [[chemotherapeutic]] agent in preventing ''A. hydrophila''.
''A. hydrophila'' can be eliminated using a 1% [[sodium hypochlorite]] solution or 2% [[calcium hypochlorite]] solution.

Brage et al., 1990 recommends fluoroquinolone administration as a prophylactic treatment during medicinal leech application.<ref>Braga A, Lineaweaver WC, Whitney TM, Follansbee S, Buncke HJ. Sensitivities of aerononas hydrophila cultured from medicinal leeches to oral antibiotics. J Reconstr Microsurg. 1990; 6(2):135-137</ref>

[[Antibiotic]]s such as [[chloramphenicol]], [[florfenicol]], [[tetracycline]], [[sulfonamide (medicine)|sulfonamide]], [[nitrofuran]] derivatives, and [[Pyridinecarboxylic acids]] are used to eliminate and control the infection of ''A. hydrophila''.

[[Terramycin]] is placed in fish food during hatchery operations as another [[chemotherapeutic]] agent in preventing ''A. hydrophila''.


S.I. Paul et al. (2021)<ref name=":0">{{Cite journal | vauthors = Paul SI, Rahman MM, Salam MA, Khan MA, Islam MT |date=2021-12-15 |title= Identification of marine sponge-associated bacteria of the Saint Martin's island of the Bay of Bengal emphasizing on the prevention of motile Aeromonas septicemia in Labeo rohita |journal=Aquaculture |volume=545 |pages=737156 |doi=10.1016/j.aquaculture.2021.737156 |bibcode=2021Aquac.54537156P |issn=0044-8486 }}</ref> isolated and identified probiotic ''Bacillus subtilis'' strain WS1A that can inhibit the growth of pathogenic ''Aeromonas'' in fish. ''Bacillus subtilis'' strain WS1A produces different types of potential [[antimicrobial peptides]].<ref name=":0" /><ref name=":1">{{cite journal | vauthors = Rahman MM, Paul SI, Akter T, Tay AC, Foysal MJ, Islam MT | title = Whole-Genome Sequence of Bacillus subtilis WS1A, a Promising Fish Probiotic Strain Isolated from Marine Sponge of the Bay of Bengal | journal = Microbiology Resource Announcements | volume = 9 | issue = 39 | date = September 2020 | pmid = 32972930 | pmc = 7516141 | doi = 10.1128/mra.00641-20 }}</ref> Fish (''Labeo rohita'') fed with extracellular products of ''Bacillus subtilis'' strain WS1A develop disease resistance against motile ''Aeromonas'' septicemia. ''Bacillus subtilis'' strain WS1A boosts immunity of treated fish. This strain was isolated from [[Sponge|marine sponge]] of [[St. Martin's Island|Saint Martin's Island]] in the [[Bay of Bengal]], [[Bangladesh]].<ref name=":0" /><ref name=":1" />
<!-- how-to===Preventing infection===
<!-- how-to===Preventing infection===
It is ill-advised to transfer fish from hatchery to hatchery without any sanitation. Hatchery workers should clean the fish, and check for bacterial infection between each operation. To avoid contamination, oxygen levels in fish should be maintained, and fish should always be handled gently, to avoid injury. [[Prophylactic]] treatments can also be used when trying to prevent ''Aeromonas hydrophila''. These treatments include disinfectants and [[Acriflavine]]. -->
It is ill-advised to transfer fish from hatchery to hatchery without any sanitation. Hatchery workers should clean the fish, and check for bacterial infection between each operation. To avoid contamination, oxygen levels in fish should be maintained, and fish should always be handled gently, to avoid injury. [[Prophylactic]] treatments can also be used when trying to prevent ''Aeromonas hydrophila''. These treatments include disinfectants and [[Acriflavine]]. -->


==References==
== References ==
{{Reflist}}
{{Reflist}}


==Further reading==
== Further reading ==
*Hayes, John. [https://web.archive.org/web/20060907035849/http://hmsc.oregonstate.edu/classes/MB492/hydrophilahayes/ ''Aeromonas hydrophila''] Oregon State University.
*Hayes, John. [https://web.archive.org/web/20060907035849/http://hmsc.oregonstate.edu/classes/MB492/hydrophilahayes/ ''Aeromonas hydrophila''] Oregon State University.
*Arrow Scientific. [http://www.arrowscientific.com.au/Bacteria_aeromonas.html ''Aeromonas hydrophila'']
*Arrow Scientific. [http://www.arrowscientific.com.au/Bacteria_aeromonas.html ''Aeromonas hydrophila'']
*[http://www.fda.gov/Food/FoodSafety/FoodborneIllness/FoodborneIllnessFoodbornePathogensNaturalToxins/BadBugBook/ucm070523.htm "''Aeromonas hydrophila''."] ''[[Bad Bug Book]]'' Foodborne Pathogenic Microorganisms and Natural Toxins Handbook. US Food and Drug Administration.
*[https://www.fda.gov/Food/FoodSafety/FoodborneIllness/FoodborneIllnessFoodbornePathogensNaturalToxins/BadBugBook/ucm070523.htm "''Aeromonas hydrophila''."] ''[[Bad Bug Book]]'' Foodborne Pathogenic Microorganisms and Natural Toxins Handbook. US Food and Drug Administration.
*[http://www.sproutnet.com/Reports/aeromonas_hydrophila.htm "''Aeromonas hydrophila'' and Related Bacteria."] International Specialty Supply.
*[http://www.sproutnet.com/Reports/aeromonas_hydrophila.htm "''Aeromonas hydrophila'' and Related Bacteria."] International Specialty Supply.
*[http://www.nydailynews.com/life-style/health/georgia-woman-flesh-eating-disease-leaves-hospital-article-1.1106858 "Georgia woman with flesh-eating disease leaves hospital"]
*[http://www.nydailynews.com/life-style/health/georgia-woman-flesh-eating-disease-leaves-hospital-article-1.1106858 "Georgia woman with flesh-eating disease leaves hospital"]


==External links==
== External links ==
* [https://web.archive.org/web/20110510185759/http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?org=gah ''Aeromonas hydrophila ATCC7966'']
* [https://web.archive.org/web/20110510185759/http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?org=gah ''Aeromonas hydrophila ATCC7966'']
*[http://bacdive.dsmz.de/index.php?search=241&submit=Search Type strain of ''Aeromonas hydrophila'' at Bac''Dive'' - the Bacterial Diversity Metadatabase]
*[http://bacdive.dsmz.de/index.php?search=241&submit=Search Type strain of ''Aeromonas hydrophila'' at Bac''Dive'' – the Bacterial Diversity Metadatabase]


{{Gram-negative proteobacterial diseases}}
{{Gram-negative proteobacterial diseases}}
{{Taxonbar|from=Q2697755}}
{{Taxonbar|from=Q2697755}}
{{Authority control}}


{{DEFAULTSORT:Aeromonas Hydrophila}}
{{DEFAULTSORT:Aeromonas Hydrophila}}

Latest revision as of 12:22, 16 May 2024

Aeromonas hydrophila
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Pseudomonadota
Class: Gammaproteobacteria
Order: Aeromonadales
Family: Aeromonadaceae
Genus: Aeromonas
Species:
A. hydrophila
Binomial name
Aeromonas hydrophila
(Chester, 1901)
Stanier, 1943
Synonyms

Bacillus hydrophilus fuscus Sanarelli 1871
Bacillus hydrophilus Chester 1901
Proteus hydrophilus (Chester 1901) Bergey et al. 1923
Bacterium hydrophilum (Chester 1901) Weldin and Levine 1923
Pseudomonas hydrophila (Chester 1901) Breed et al. 1948

Aeromonas hydrophila colonies on the blood agar.

Aeromonas hydrophila is a heterotrophic, Gram-negative, rod-shaped bacterium mainly found in areas with a warm climate. This bacterium can be found in fresh or brackish water. It can survive in aerobic and anaerobic environments, and can digest materials such as gelatin and hemoglobin. A. hydrophila was isolated from humans and animals in the 1950s. It is the best known of the species of Aeromonas. It is resistant to most common antibiotics and cold temperatures and is oxidase- and indole-positive. Aeromonas hydrophila also has a symbiotic relationship as gut flora inside of certain leeches, such as Hirudo medicinalis.[1]

Structure

[edit]

Aeromonas hydrophila bacteria are Gram-negative, straight rods with rounded ends (bacilli to coccibacilli shape) usually from 0.3 to 1.0 μm in width and 1.0 to 3.0 μm in length. They can grow at temperatures as low as 4 °C. These bacteria are motile by a polar flagellum.

Pathology

[edit]

Because of its structure, it is very toxic to many organisms. When it enters the body of its victim, it travels through the bloodstream to the first available organ. It produces aerolysin, a cytotoxic enterotoxin that can cause tissue damage. A. hydrophila, A. caviae, and A. sobria are all considered to be opportunistic pathogens, meaning they rarely infect healthy individuals. A. hydrophila is widely considered a major fish and amphibian pathogen,[2] and its pathogenicity in humans has been recognized for decades.[3] The genomic insights of aeromonas could be a stepping stone into understanding of them[4]

Pathogenic mechanism

[edit]

The pathogenicity of Aeromonas species was believed to be mediated by a number of extracellular proteins such as aerolysin, lipase, chitinase, amylase, gelatinase, hemolysins, and enterotoxins. However, the pathogenic mechanisms are unknown. The recently proposed type-III secretion system (T3SS) has been linked to Aeromonas pathogenesis. T3SS is a specialized protein secretion machinery that exports virulence factors directly to host cells. These factors subvert normal host cell functions to the benefit of invading bacteria. In contrast to the general secretory pathway, the T3SS is triggered when a pathogen comes in contact with host cells. ADP-ribosylation toxin is one of the effector molecules secreted by several pathogenic bacteria and translocated through the T3SS and delivered into the host cytoplasm, which leads to interruption of the NF-κB pathway, cytoskeletal damage, and apoptosis. This toxin has been characterized in A. hydrophila (human diarrhoeal isolate), A. salmonicida (fish pathogen), and A. jandaei GV17, a pathogenic strain that can cause disease both in humans and fish.

Occurrence of exposure

[edit]

Aeromonas hydrophila infections occur most often during sexual changes, stressors, changes in temperature, in contaminated environments, and when an organism is already infected with a virus or another bacterium. It can also be ingested through food products contaminated with the bacterium, such as seafood, meats, and even certain vegetables such as sprouts. It can also be transmitted by leeches.[5]

Fish and amphibians

[edit]

Aeromonas hydrophila is associated with diseases mainly found in freshwater fish and amphibians, because these organisms live in aquatic environments. It is linked to a disease found in frogs called red leg, which causes internal, sometimes fatal hemorrhaging. When infected with A. hydrophila, fish develop ulcers, tail rot, fin rot, and hemorrhagic septicemia. Hemorrhagic septicaemia causes lesions that lead to scale shedding, hemorrhages in the gills and anal area, ulcers, exophthalmia, and abdominal swelling.

Human diseases

[edit]

Aeromonas hydrophila is not as pathogenic to humans as it is to fish and amphibians. One of the diseases it can cause in humans, gastroenteritis, occurs mostly in young children and people who have compromised immune systems or growth problems. This bacterium is linked to two types of gastroenteritis. The first type is a disease similar to cholera, which causes rice-water diarrhea. The other type is dysenteric gastroenteritis, which causes loose stools filled with blood and mucus. Dysenteric gastroenteritis is the most severe out of the two types and can last for several weeks. A. hydrophila is also associated with cellulitis.[6] It also causes diseases such as myonecrosis and eczema in people with compromised or suppressed (by medication) immune systems.[7] In very rare cases, A. hydrophila can cause necrotizing fasciitis.[8]

Outbreaks

[edit]

Though A. hydrophila can cause serious disease, large scale outbreaks have not been reported. Outbreaks among vertebrates have occurred. One such incident occurred in Puerto Rico inside the intestinal tracts of lizards.[9] Some 116 different strains were found in the lizards. On May 1, 1988, a small outbreak happened in California. The 225 isolates in 219 patients caused their hospital admissions. Confidential morbidity report cards were used to report the cases to the local health departments. Investigations were conducted, and reports were sent to the California Department of Health Services for diagnosis and methods in treatment.

Treatments

[edit]

Aeromonas hydrophila can be eliminated using a 1% sodium hypochlorite solution or 2% calcium hypochlorite solution. Brage et al., 1990 recommends fluoroquinolone administration as prophylactic treatment during medicinal leech application.[10] Antibiotics such as chloramphenicol, florfenicol, tetracycline, sulfonamide, nitrofuran derivatives, and Pyridinecarboxylic acids are used to eliminate and control the infection of A. hydrophila. Terramycin is placed in fish food during hatchery operations as another chemotherapeutic agent in preventing A. hydrophila.

S.I. Paul et al. (2021)[11] isolated and identified probiotic Bacillus subtilis strain WS1A that can inhibit the growth of pathogenic Aeromonas in fish. Bacillus subtilis strain WS1A produces different types of potential antimicrobial peptides.[11][12] Fish (Labeo rohita) fed with extracellular products of Bacillus subtilis strain WS1A develop disease resistance against motile Aeromonas septicemia. Bacillus subtilis strain WS1A boosts immunity of treated fish. This strain was isolated from marine sponge of Saint Martin's Island in the Bay of Bengal, Bangladesh.[11][12]

References

[edit]
  1. ^ Sawyer RT (1986). "Leech Biology and Behaviour". Feeding, Biology. Ecology and Systematic (PDF). Vol. II. Oxford: Clarendon Press. Retrieved 18 August 2020 – via Biopharm Leeches.
  2. ^ Hazen TC, Fliermans CB, Hirsch RP, Esch GW (November 1978). "Prevalence and distribution of Aeromonas hydrophila in the United States". Applied and Environmental Microbiology. 36 (5): 731–8. Bibcode:1978ApEnM..36..731H. doi:10.1128/aem.36.5.731-738.1978. PMC 243130. PMID 31839.
  3. ^ Agger WA, McCormick JD, Gurwith MJ (June 1985). "Clinical and microbiological features of Aeromonas hydrophila-associated diarrhea". Journal of Clinical Microbiology. 21 (6): 909–13. doi:10.1128/jcm.21.6.909-913.1985. PMC 271816. PMID 4008621.
  4. ^ Tan WS, Yin WF, Chan KG (January 2015). "Insights into the Quorum-Sensing Activity in Aeromonas hydrophila Strain M013 as Revealed by Whole-Genome Sequencing". Genome Announcements. 3 (1): 1–2. doi:10.1128/genomeA.01372-14. PMC 4293626. PMID 25555739.
  5. ^ Snower DP, Ruef C, Kuritza AP, Edberg SC (June 1989). "Aeromonas hydrophila infection associated with the use of medicinal leeches". Journal of Clinical Microbiology. 27 (6): 1421–2. doi:10.1128/jcm.27.6.1421-1422.1989. PMC 267578. PMID 2666448.
  6. ^ "Cellulitis". The Lecturio Medical Concept Library. Retrieved 7 July 2021.
  7. ^ Janda JM, Abbott SL (August 1998). "Evolving concepts regarding the genus Aeromonas: an expanding Panorama of species, disease presentations, and unanswered questions". Clinical Infectious Diseases. 27 (2): 332–44. doi:10.1086/514652. PMID 9709884.
  8. ^ Minnaganti VR, Patel PJ, Iancu D, Schoch PE, Cunha BA (2000). "Necrotizing fasciitis caused by Aeromonas hydrophila". Heart & Lung. 29 (4): 306–8. doi:10.1067/mhl.2000.106723. PMID 10900069.
  9. ^ Fulton MA (1965). "The bacterium Aeromonas hydriphila from lizards of the genus Anolis in Puerto Rico" (PDF). Carib. Jour. Sci. 2: 105–7. Archived from the original (PDF) on October 31, 2004.
  10. ^ Braga A, Lineaweaver WC, Whitney TM, Follansbee S, Buncke HJ (April 1990). "Sensitivities of Aeromonas hydrophila cultured from medicinal leeches to oral antibiotics". Journal of Reconstructive Microsurgery. 6 (2): 135–7. doi:10.1055/s-2007-1006813. PMID 2352221.
  11. ^ a b c Paul SI, Rahman MM, Salam MA, Khan MA, Islam MT (2021-12-15). "Identification of marine sponge-associated bacteria of the Saint Martin's island of the Bay of Bengal emphasizing on the prevention of motile Aeromonas septicemia in Labeo rohita". Aquaculture. 545: 737156. Bibcode:2021Aquac.54537156P. doi:10.1016/j.aquaculture.2021.737156. ISSN 0044-8486.
  12. ^ a b Rahman MM, Paul SI, Akter T, Tay AC, Foysal MJ, Islam MT (September 2020). "Whole-Genome Sequence of Bacillus subtilis WS1A, a Promising Fish Probiotic Strain Isolated from Marine Sponge of the Bay of Bengal". Microbiology Resource Announcements. 9 (39). doi:10.1128/mra.00641-20. PMC 7516141. PMID 32972930.

Further reading

[edit]
[edit]
Retrieved from "https://en.wikipedia.org/enwiki/w/index.php?title=Aeromonas_hydrophila&oldid=1224129478"