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'''Robert S. Coleman''' (b 1959) is an American chemistry professor and researcher.
{{Orphan|date=February 2009}}
Coleman was a faculty member at both [[Ohio State University]] and the [[University of South Carolina]]. At Ohio State, he was on the faculty in the Department of Chemistry from 1996 to 2012, having moved to Ohio State as an associate professor from the [[University of South Carolina]]. At USC, Coleman taught as assistant professor from 1989 to 1995, and then as associate professor (with tenure) from 1995 to 1996. In 1996, he accepted a faculty position at Ohio State University to teach Organic Chemistry, where he was an associate professor from 1996 until 2000. He was promoted to full professor in 2000, teaching Organic Chemistry up until his retirement in 2012. He received his Ph.D. degree working with Professor [[Dale L. Boger]] (then at Purdue), completing the first total synthesis of the antitumor agent [[CC-1065]].<ref>{{cite journal | doi =10.1021/ja00222a043 | title =Total synthesis of (±)-N2-(phenylsulfonyl)-CPI, (±)-CC-1065, (+)-CC-1065, ent-(−)-CC-1065, and the precise, functional agents (±)-CPI-CDPI2, (+)-CPI-CDPI2, and (−)-CPI-CDPI2 \(±)-(3bR*,4aS*)-, (+)-(3bR,4aS)-, and (−)-(3bS,4aR)-deoxy-CC-1065 | year =1988 | last1 =Boger | first1 =Dale L. | last2 =Coleman | first2 =Robert S. | journal =Journal of the American Chemical Society | volume =110 | issue =14 | pages =4796}}</ref> He was subsequently an NIH postdoctoral fellow at [[Yale University]] with Professor [[Samuel J. Danishefsky]], where he completed (with M. Paz Cabal), the first total synthesis of the aglycone of the antitumor agent [[calicheamicin]].<ref>{{cite journal | doi = 10.1021/ja00164a079 | title = Total synthesis of calicheamicinone: A solution to the problem of the elusive urethane | year = 1990 | last1 = Cabal | first1 = Maria Paz | last2 = Coleman | first2 = Robert S. | last3 = Danishefsky | first3 = Samuel J. | journal = Journal of the American Chemical Society | volume = 112 | issue = 8 | pages = 3253}}</ref>
{{notability|date=OCtober 2012}}

'''Robert S. Coleman''' is a faculty member at [[Ohio State University]]. He has been on the faculty in the Department of Chemistry since 1996, having moved to Ohio State as an Associate Professor from the [[University of South Carolina]], after seven years at that institution. He was promoted to Full Professor in 2000. Professor Coleman is nationally and internationally recognized as a leading practitioner in the field of [[organic synthesis|synthetic organic]] and [[medicinal chemistry]], and as a collaborator in a number of multidisciplinary research programs. He received his Ph.D. degree working with Professor [[Dale L. Boger]] (then at Purdue), completing the first total synthesis of the antitumor agent [[CC-1065]].<ref>''J. Am. Chem. Soc.'' 1988, 10, 1321</ref> He was subsequently an NIH postdoctoral fellow at [[Yale University]] with Professor [[Samuel J. Danishefsky]], where he completed (with M. Paz Cabal), the first total synthesis of the aglycone of the antitumor agent [[calicheamicin]].<ref>''J. Am. Chem. Soc.'' '''1990''', ''112'', 3253</ref>
==Research==
==Research==
Professor Coleman's independent research contributions include:
Coleman's independent research contributions include:


* Accomplished the first total chemical synthesis of the novel antitumor agent [[azinomycin A]] <ref>''Angew. Chem., Int. Ed.'' '''2001''', ''40'', 1736</ref>
* Accomplished the first total chemical synthesis of the novel antitumor agent [[azinomycin A]]<ref>{{cite journal | doi = 10.1002/1521-3757(20010504)113:9<1786::AID-ANGE17860>3.0.CO;2-I | title = Total Synthesis of Azinomycin A | year = 2001 | last1 = Coleman | first1 = Robert S. | last2 = Li | first2 = Jing | last3 = Navarro | first3 = Antonio | journal = Angewandte Chemie | volume = 113 | issue = 9 | pages = 1786| bibcode = 2001AngCh.113.1786C }}</ref>
* Developed the first synthesis of DNA containing sulfur-bearing [[nucleoside]]s <ref>''J. Am. Chem. Soc.'' '''1992''', ''114'', 9229</ref>
* Developed the first synthesis of DNA containing sulfur-bearing [[nucleoside]]s <ref>{{cite journal | doi = 10.1021/ja00049a089 | title = Synthesis of a 4-thio-2'-deoxyuridine containing oligonucleotide. Development of the thiocarbonyl group as a linker element | year = 1992 | last1 = Coleman | first1 = Robert S. | last2 = Siedlecki | first2 = James M. | journal = Journal of the American Chemical Society | volume = 114 | issue = 23 | pages = 9229}}</ref>
* Developed the first stereocontrolled total synthesis of the kinase inhibitor [[calphostin A]] <ref>''J. Am. Chem. Soc.'' '''1995''', ''117'', 10889</ref>
* Developed the first stereocontrolled total synthesis of the kinase inhibitor [[calphostin A]]<ref>{{cite journal | doi = 10.1021/ja00149a012 | title = Synthesis of Helically Chiral Molecules: Stereoselective Total Synthesis of the Perylenequinones Phleichrome and Calphostin A | year = 1995 | last1 = Coleman | first1 = Robert S. | last2 = Grant | first2 = Eugene B. | journal = Journal of the American Chemical Society | volume = 117 | issue = 44 | pages = 10889}}</ref>
* Developed the first computer generated model of an [[azinomycin B]]/DNA crosslink <ref>''J. Med. Chem.'' '''2002''', ''45'', 861</ref>
* Developed the first computer generated model of an [[azinomycin B]]/DNA crosslink <ref>{{cite journal | doi = 10.1021/jm011040w | title = DNA Cross-Linking by Azinomycin B: Monte Carlo Simulations in the Evaluation of Sequence Selectivity | year = 2002 | last1 = Alcaro | first1 = Stefano | last2 = Ortuso | first2 = Francesco | last3 = Coleman | first3 = Robert S. | journal = Journal of Medicinal Chemistry | volume = 45 | issue = 4 | pages = 861–70 | pmid = 11831897}}</ref>
* Developed the first fluorescent probe for studying ultrafast DNA dynamics <ref>''J. Org. Chem.'' '''1998''', ''63'', 5700</ref>
* Developed the first fluorescent nucleotide probe for studying ultrafast DNA dynamics <ref>{{cite journal | doi = 10.1021/jo980478+| title = Synthesis of a Novel Coumarin C-Riboside as a Photophysical Probe of Oligonucleotide Dynamics | year = 1998 | last1 = Coleman | first1 = Robert S. | last2 = Madaras | first2 = Mihaela L. | journal = The Journal of Organic Chemistry | volume = 63 | issue = 16 | pages = 5700}}</ref>
* Published the first comprehensive study of the DNA binding properties of azinomycin B <ref>{{cite journal | doi = 10.1021/ja025563k | title = Studies on the Mechanism of Action of Azinomycin B: Definition of Regioselectivity and Sequence Selectivity of DNA Cross-Link Formation and Clarification of the Role of the Naphthoate | year = 2002 | last1 = Coleman | first1 = Robert S. | last2 = Perez | first2 = Ronelito J. | last3 = Burk | first3 = Christopher H. | last4 = Navarro | first4 = Antonio | journal = Journal of the American Chemical Society | volume = 124 | issue = 44 | pages = 13008–17 | pmid = 12405827}}</ref>
* Published the first comprehensive study of the DNA binding properties of azinomycin B <ref>''J. Am. Chem. Soc.'' '''2002''', ''124'', 13008</ref>
* Developed a novel hetero-bis-metallated [[butadiene]] for the synthesis of polyene [[natural product]]s,<ref>''Org. Lett.'' '''2005''', ''7'', 2289</ref> including the first total synthesis of the antitumor agent [[lucilactaene]] <ref>''J. Am. Chem. Soc.'' '''2005''', ''127'', 16038</ref> and 2'-O-methylmyxalamide D.<ref> ''J. Am. Chem. Soc.'' '''2007''', ''129'', 3826</ref>
* Developed a novel hetero-bis-metallated [[butadiene]] for the synthesis of polyene [[natural product]]s,<ref>{{cite journal | doi = 10.1021/ol050768u | title = Tandem Stille/Suzuki−Miyaura Coupling of a Hetero-Bis-metalated Diene. Rapid, One-Pot Assembly of Polyene Systems | year = 2005 | last1 = Coleman | first1 = Robert S. | last2 = Walczak | first2 = Matthew C. | journal = Organic Letters | volume = 7 | issue = 11 | pages = 2289–91 | pmid = 15901191}}</ref> including the first total synthesis of the antitumor agent [[lucilactaene]]<ref>{{cite journal | doi = 10.1021/ja056217g | title = Total Synthesis of Lucilactaene, A Cell Cycle Inhibitor Active in p53-Inactive Cells | year = 2005 | last1 = Coleman | first1 = Robert S. | last2 = Walczak | first2 = Matthew C. | last3 = Campbell | first3 = Erica L. | journal = Journal of the American Chemical Society | volume = 127 | issue = 46 | pages = 16038–9 | pmid = 16287286}}</ref> and 2'-O-methylmyxalamide D.<ref>{{cite journal | doi = 10.1021/ja070265e | title = Total Synthesis of 2'-O-Methylmyxalamide D and (6E)-2'-O-Methylmyxalamide D | year = 2007 | last1 = Coleman | first1 = Robert S. | last2 = Lu | first2 = Xiaoling | last3 = Modolo | first3 = Isabelle | journal = Journal of the American Chemical Society | volume = 129 | issue = 13 | pages = 3826–7 | pmid = 17358066}}</ref>

Professor Coleman has been an invited speaker at numerous scientific conferences, including several international conferences. He has been invited to visit most major pharmaceutical companies to present his research, including [[Merck & Co.|Merck]], [[Pfizer]], [[Glaxo]], [[Eli Lilly and Company|Lilly]], [[Schering-Plough]], [[Wyeth-Ayerst]], [[Bristol-Myers Squibb]], [[Amgen]], [[Sepracor]], and [[Genentech]].

Professor Coleman has received a number of awards for research. He held an NIH postdoctoral fellowship at Yale, and was a Dreyfus Foundation Distinguished New Faculty Awardee (1989-1994), an American Cancer Society Junior Faculty Research Awardee (1991-1993), and a Sloan Foundation Research Fellow (1995-1998). In addition, he has won teaching awards at both University of South Carolina and Ohio State University (Alumni Distinguished Teaching Award, 1998). He was elected a Fellow of the American Association for the Advancement of Science in 2008. Professor Coleman has a diverse publication record within the general field of synthetic organic and medicinal chemistry. He has nearly 100 publications to his credit, and he has been a major recipient of federal and private funding, having received more than $5.8M during the course of his independent career.

Professor Coleman has served as an expert witness for in a number of intellectual property rights cases concerning pharmaceutical patents.

Professor Coleman was Vice Chair for Graduate Studies in the Department of Chemistry at Ohio State from 2007-2011 and Chair of the Committee on Academic Misconduct. He was Chair of the University Research Committee and was responsible for the development and adoption of the Ohio State University policy on Research Misconduct. Professor Coleman retired from Ohio State University in 2012, becoming Professor Emeritus at age 52.


==References==
==References==
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==External links==
==External links==
* [http://www.chemistry.ohio-state.edu/~coleman/ Coleman Research Group]
* [https://chemistry.osu.edu/people/coleman.184 Coleman faculty page]
* [http://academic.research.microsoft.com/Author/3592468/robert-s-coleman]

{{authority control}}


{{Persondata <!-- Metadata: see [[Wikipedia:Persondata]]. -->
| NAME = Coleman, Robert S.
| ALTERNATIVE NAMES =
| SHORT DESCRIPTION =
| DATE OF BIRTH =
| PLACE OF BIRTH =
| DATE OF DEATH =
| PLACE OF DEATH =
}}
{{DEFAULTSORT:Coleman, Robert S.}}
{{DEFAULTSORT:Coleman, Robert S.}}
[[Category:American chemists]]
[[Category:21st-century American chemists]]
[[Category:Ohio State University faculty]]
[[Category:Ohio State University faculty]]
[[Category:Living people]]
[[Category:Living people]]
[[Category:University of South Carolina faculty]]
[[Category:University of South Carolina faculty]]
[[Category:Yale University fellows]]
[[Category:Yale University fellows]]
[[Category:Year of birth missing (living people)]]

Latest revision as of 01:20, 9 June 2024

Robert S. Coleman (b 1959) is an American chemistry professor and researcher. Coleman was a faculty member at both Ohio State University and the University of South Carolina. At Ohio State, he was on the faculty in the Department of Chemistry from 1996 to 2012, having moved to Ohio State as an associate professor from the University of South Carolina. At USC, Coleman taught as assistant professor from 1989 to 1995, and then as associate professor (with tenure) from 1995 to 1996. In 1996, he accepted a faculty position at Ohio State University to teach Organic Chemistry, where he was an associate professor from 1996 until 2000. He was promoted to full professor in 2000, teaching Organic Chemistry up until his retirement in 2012. He received his Ph.D. degree working with Professor Dale L. Boger (then at Purdue), completing the first total synthesis of the antitumor agent CC-1065.[1] He was subsequently an NIH postdoctoral fellow at Yale University with Professor Samuel J. Danishefsky, where he completed (with M. Paz Cabal), the first total synthesis of the aglycone of the antitumor agent calicheamicin.[2]

Research

[edit]

Coleman's independent research contributions include:

  • Accomplished the first total chemical synthesis of the novel antitumor agent azinomycin A[3]
  • Developed the first synthesis of DNA containing sulfur-bearing nucleosides [4]
  • Developed the first stereocontrolled total synthesis of the kinase inhibitor calphostin A[5]
  • Developed the first computer generated model of an azinomycin B/DNA crosslink [6]
  • Developed the first fluorescent nucleotide probe for studying ultrafast DNA dynamics [7]
  • Published the first comprehensive study of the DNA binding properties of azinomycin B [8]
  • Developed a novel hetero-bis-metallated butadiene for the synthesis of polyene natural products,[9] including the first total synthesis of the antitumor agent lucilactaene[10] and 2'-O-methylmyxalamide D.[11]

References

[edit]
  1. ^ Boger, Dale L.; Coleman, Robert S. (1988). "Total synthesis of (±)-N2-(phenylsulfonyl)-CPI, (±)-CC-1065, (+)-CC-1065, ent-(−)-CC-1065, and the precise, functional agents (±)-CPI-CDPI2, (+)-CPI-CDPI2, and (−)-CPI-CDPI2 \(±)-(3bR*,4aS*)-, (+)-(3bR,4aS)-, and (−)-(3bS,4aR)-deoxy-CC-1065". Journal of the American Chemical Society. 110 (14): 4796. doi:10.1021/ja00222a043.
  2. ^ Cabal, Maria Paz; Coleman, Robert S.; Danishefsky, Samuel J. (1990). "Total synthesis of calicheamicinone: A solution to the problem of the elusive urethane". Journal of the American Chemical Society. 112 (8): 3253. doi:10.1021/ja00164a079.
  3. ^ Coleman, Robert S.; Li, Jing; Navarro, Antonio (2001). "Total Synthesis of Azinomycin A". Angewandte Chemie. 113 (9): 1786. Bibcode:2001AngCh.113.1786C. doi:10.1002/1521-3757(20010504)113:9<1786::AID-ANGE17860>3.0.CO;2-I.
  4. ^ Coleman, Robert S.; Siedlecki, James M. (1992). "Synthesis of a 4-thio-2'-deoxyuridine containing oligonucleotide. Development of the thiocarbonyl group as a linker element". Journal of the American Chemical Society. 114 (23): 9229. doi:10.1021/ja00049a089.
  5. ^ Coleman, Robert S.; Grant, Eugene B. (1995). "Synthesis of Helically Chiral Molecules: Stereoselective Total Synthesis of the Perylenequinones Phleichrome and Calphostin A". Journal of the American Chemical Society. 117 (44): 10889. doi:10.1021/ja00149a012.
  6. ^ Alcaro, Stefano; Ortuso, Francesco; Coleman, Robert S. (2002). "DNA Cross-Linking by Azinomycin B: Monte Carlo Simulations in the Evaluation of Sequence Selectivity". Journal of Medicinal Chemistry. 45 (4): 861–70. doi:10.1021/jm011040w. PMID 11831897.
  7. ^ Coleman, Robert S.; Madaras, Mihaela L. (1998). "Synthesis of a Novel Coumarin C-Riboside as a Photophysical Probe of Oligonucleotide Dynamics". The Journal of Organic Chemistry. 63 (16): 5700. doi:10.1021/jo980478+.
  8. ^ Coleman, Robert S.; Perez, Ronelito J.; Burk, Christopher H.; Navarro, Antonio (2002). "Studies on the Mechanism of Action of Azinomycin B: Definition of Regioselectivity and Sequence Selectivity of DNA Cross-Link Formation and Clarification of the Role of the Naphthoate". Journal of the American Chemical Society. 124 (44): 13008–17. doi:10.1021/ja025563k. PMID 12405827.
  9. ^ Coleman, Robert S.; Walczak, Matthew C. (2005). "Tandem Stille/Suzuki−Miyaura Coupling of a Hetero-Bis-metalated Diene. Rapid, One-Pot Assembly of Polyene Systems". Organic Letters. 7 (11): 2289–91. doi:10.1021/ol050768u. PMID 15901191.
  10. ^ Coleman, Robert S.; Walczak, Matthew C.; Campbell, Erica L. (2005). "Total Synthesis of Lucilactaene, A Cell Cycle Inhibitor Active in p53-Inactive Cells". Journal of the American Chemical Society. 127 (46): 16038–9. doi:10.1021/ja056217g. PMID 16287286.
  11. ^ Coleman, Robert S.; Lu, Xiaoling; Modolo, Isabelle (2007). "Total Synthesis of 2'-O-Methylmyxalamide D and (6E)-2'-O-Methylmyxalamide D". Journal of the American Chemical Society. 129 (13): 3826–7. doi:10.1021/ja070265e. PMID 17358066.
[edit]
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