Gluconate 2-dehydrogenase (acceptor)

Gluconate 2-dehydrogenase (acceptor)
Identifiers
EC no.	1.1.99.3
CAS no.	9028-81-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a gluconate 2-dehydrogenase (acceptor) (EC 1.1.99.3) is an enzyme that catalyzes the chemical reaction

D-gluconate + acceptor $\rightleftharpoons$ 2-dehydro-D-gluconate + reduced acceptor

Thus, the two substrates of this enzyme are D-gluconate and acceptor, whereas its two products are 2-dehydro-D-gluconate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is D-gluconate:acceptor 2-oxidoreductase. Other names in common use include gluconate oxidase, gluconate dehydrogenase, gluconic dehydrogenase, D-gluconate dehydrogenase, gluconic acid dehydrogenase, 2-ketogluconate reductase, D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding, and D-gluconate:(acceptor) 2-oxidoreductase. This enzyme participates in pentose phosphate pathway. It employs one cofactor, FAD.

References

• Matsushita K, Shinagawa E, Ameyama M (1982). "D-Gluconate dehydrogenase from bacteria, 2-keto-d-gluconate-yielding, membrane-bound". Carbohydrate Metabolism - Part D. Methods in Enzymology. Vol. 89. pp. 187–93. doi:10.1016/s0076-6879(82)89033-2. ISBN 978-0-12-181989-7. PMID 6815420.
• Ramakrishnan T; Campbell JJR (1955). "Gluconic dehydrogenase of Pseudomonas aeruginosa". Biochim. Biophys. Acta. 17 (1): 122–127. doi:10.1016/0006-3002(55)90326-7. PMID 13239635.