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{{Infobox scientist
{{AFC submission|d|bio|u=Schuldiner'slab|ns=118|decliner=Bradv|declinets=20160731141616|ts=20160731141341}} <!-- Do not remove this line! -->
| image = Shimon Schuldiner 1.jpg
| name = Shimon Schuldiner
| birth_place = [[Buenos Aires]], Argentina
| nationality = [[Israelis|Israeli]]
| field = [[Biochemistry]]
| work_institution = [[The Hebrew University of Jerusalem]]
| known_for = Research of [[Membrane transport protein|trans-membrane transporters]]
}}


⚫
'''Shimon Schuldiner''' (born August 10, 1946) is an Israeli [[biochemist]]. He has made important contributions to the understanding of [[proteins]] that couple the movement of [[ions]] and other [[molecules]] across [[biological membrane|membranes]]. Schuldiner is Mathilda Marks-Kennedy Professor at the [[Alexander Silberman Institute of Life Sciences]], the [[Hebrew University of Jerusalem]]. He received a B.Sc. in 1967 and an M.Sc. in 1968 from the Hebrew University of Jerusalem, and a Ph.D. from the [[Weizmann Institute of Science]] in [[Rehovot]] in 1973.<ref>{{cite web|url=http://biolchem.huji.ac.il/shimons/ |title=HP |publisher=Biolchem.huji.ac.il |date= |accessdate=2016-08-15}}</ref><ref>{{cite web|url=http://f1000.com/prime/thefaculty/member/1800182585196021 |title=Shimon Schuldiner: Faculty Member in Neuronal Signaling Mechanisms - F1000Prime |publisher=F1000.com |date=2013-01-22 |accessdate=2016-08-15}}</ref>
{{AFC comment|1=Many of the references listed are self-published. Wikipedia relies on secondary sources, meaning articles or books ''about'' Schuldiner, not ''by'' Schuldiner. Is there anything else available? [[User_talk:Bradv|<span style="text-shadow:lightgray 0.2em 0.2em 0.2em;color:#C60">Brad<i>v</i></span>]] 14:16, 31 July 2016 (UTC)}}

----

⚫
Shimon Schuldiner (born August 10, 1946) is an Israeli [[biochemist]] who has made important contributions to the understanding of [[proteins]] that couple the movement of [[ions]] and other [[molecules]] across [[membranes]]. Schuldiner is Mathilda Marks-Kennedy Professor Emeritus at the [[Hebrew University in Jerusalem]]. He received a B.Sc. in 1967 and an M.Sc. in 1968 from the Hebrew University in Jerusalem, and a Ph.D. from the [[Weizmann Institute of Science]] in [[Rehovot]] in 1973<ref>http://biolchem.huji.ac.il/shimons/</ref> <ref>http://f1000.com/prime/thefaculty/member/1800182585196021</ref>.


== Biography ==
== Biography ==

Schuldiner was born in August 10, 1946 in [[Buenos Aires]], [[Argentina]], to '''[Name and Name Schuldiner, =names of parents]''', who were [Polish? Russian?] Jewish immigrants. [some ref? anybody wrote some bio on him somewhere, even short of a few para? you can ask Monica for info on parents][out from Eastern Europe]. In 1964 he emigrated to [[Israel]] and has been living there since. He earned a B.Sc. in 1967 and a M.Sc. in 1968 at the Hebrew University in Jerusalem, the latter working with Itzhak Ohad. In 1973 he received a Ph.D. for work performed in the laboratory of Mordhay Avron (z"l) at the Weizmann Institute of Science in Rehovot [on what topic? copy from his bio]. From 1973-1976 he did post-doctoral research in the laboratory of H. Ronald Kaback at the Roche Institute for Molecular Biology in Nutley, New Jersey. In 1976 he returned to Israel [did he serve in the Army at all? that’s good juicy info] and joined the Department of Molecular Biology at Hadassah Medical School, and in 1990 he moved to the Alexander Silberman Institute of Life Sciences, both at the Hebrew University in Jerusalem. Between 1999-2002 he served as Chairman of the Silberman Institute. Schuldiner is married to Monica Schuldiner, has two children and six grandchildren. He and his wife are [take note the sentence’s changed] long-time supporters of civil rights in Israel and of the advancement of peace. His son Oren <ref>http://heb.wis-wander.weizmann.ac.il/%D7%94%D7%92%D7%A0%D7%9F-%D7%94%D7%9E%D7%A1%D7%95%D7%A8/%D7%9E%D7%93%D7%A2%D7%99-%D7%94%D7%97%D7%99%D7%99%D7%9D</ref> and his daughter-in-law Maya Schuldiner <ref>http://www.weizmann.ac.il/molgen/Maya/</ref> <ref>http://www.haaretz.co.il/magazine/.premium-1.2906090</ref> are also research biologists, investigators at the Weizmann Institute of Science.
Schuldiner was born on August 10, 1946, in [[Buenos Aires]], [[Argentina]], to Hana Joszpe and Berko Schuldiner, who were [[Jewish]] [[immigrants]] from [[Ukraine]]. In 1964 he [[Aliyah|emigrated to Israel]], where he has been living since. He earned a B.Sc. in 1967 and a M.Sc. in 1968 from the Hebrew University of Jerusalem, the latter working with Itzhak Ohad. In 1973 he received a Ph.D. for work performed in the laboratory of Mordhay Avron (z"l) <ref>Gromet-Elhanan, Z. (1992) Journal of Bioenergetics and Biomembranes 24, 520-521</ref> at the Weizmann Institute of Science in Rehovot . From 1973 to 1976 he did postdoctoral research in the laboratory of [[Howard Ronald Kaback]] at the Roche Institute for Molecular Biology in [[Nutley, New Jersey]]. In 1976 he returned to Israel and joined the Department of Molecular Biology at [[Hadassah Medical School]], and in 1990 he moved to the Alexander Silberman Institute of Life Sciences, both at the Hebrew University of Jerusalem. Between 1999 and 2002, he served as Chairman of the Silberman Institute. Schuldiner is married to Monica Schuldiner, with whom he has two children and six grandchildren. He and his wife are long-time supporters of civil rights in Israel and of the advancement of peace. His son Oren<ref>{{cite web|url=http://www.weizmann.ac.il/mcb/Schuldiner/home |title=Home &#124; Oren Schuldiner's Lab |publisher=Weizmann.ac.il |date=2016-07-27 |accessdate=2016-08-15}}</ref> and his daughter-in-law Maya Schuldiner <ref>{{cite web|url=http://www.weizmann.ac.il/molgen/Maya/ |title=Maya Schuldiner |publisher=Weizmann.ac.il |date= |accessdate=2016-08-15}}</ref><ref>{{cite web|url=http://www.haaretz.co.il/magazine/.premium-1.2906090 |title=יוצאות מהמעבדה: המדעניות מביאות את האִמָּהוּת לעבודה - סוף שבוע - הארץ |publisher=Haaretz.co.il |date=2010-01-20 |accessdate=2016-08-15}}</ref> are also research biologists, working at the Weizmann Institute of Science. His son Ilan is a physiotherapist at Maccabi Health Services and his daughter in law, Hila Zadka, is a researcher at The Israel Center for Disease Control, Israel Ministry of Health.


== Career ==
== Career ==
Schuldiner is a world expert in the expression, purification and characterization of [[membrane proteins]]. Specifically, he focused on the [[multidrug antiporter]] EmrE, investigation of its subunit structure led them to propose a [[dimer]] of [[topologically]] parallel subunits. This led to a long-running controversy over EmrE topology that eventually led to Schuldiner to demonstrate that both parallel and antiparallel dimers are functional <ref> , http://mpec.ucsf.edu/about/schuldiner.htm </ref> <ref> Woodall, N. B., Yin, Y., and Bowie, J. U. (2015) Nat Commun 6 </ref>. His work on the Vesicular Monoamine Transporter ([[VMAT]]), elucidating it's mechanism of action<ref>http://www.medicalnewstoday.com/releases/259963.php </ref> <ref> http://www.eurekalert.org/pub_releases/2013-05/thuo-io050113.php </ref> is a key for the development of better drugs for brain disorders <ref>https://www.highbeam.com/doc/1G1-356657672.html </ref>
Schuldiner is a world expert in the expression, purification, and characterization of [[membrane proteins]]. Specifically, he focuses on the multidrug [[antiporter]] EmrE. Investigation of its subunit structure led the Schuldiner Group to propose a [[protein dimer|dimer]] of [[topologically]] parallel subunits. This led to a long-running controversy over EmrE topology that eventually led Schuldiner to demonstrate that both parallel and antiparallel dimers are functional.<ref>{{cite web|url=http://mpec.ucsf.edu/about/schuldiner.htm |title=MPEC : About |publisher=Mpec.ucsf.edu |date= |accessdate=2016-08-15}}</ref><ref>Woodall, N. B., Yin, Y., and Bowie, J. U. (2015) Nat Commun 6</ref> His work on the Vesicular Monoamine Transporter ([[VMAT]]), elucidating its mechanism of action,<ref>{{cite web|url=http://www.medicalnewstoday.com/releases/259963.php |title=The Up And Down Side Of 'Traffic' In Our Cells |publisher=Medical News Today |date= |accessdate=2016-08-15}}</ref><ref>{{cite web|url=http://www.eurekalert.org/pub_releases/2013-05/thuo-io050113.php |title='Traffic' in our cells works both for and against us &#124; EurekAlert! Science News |publisher=Eurekalert.org |date=2013-05-01 |accessdate=2016-08-15}}</ref> is essential for the development of better drugs for brain disorders.<ref>[https://web.archive.org/web/20160911011233/https://www.highbeam.com/doc/1G1-356657672.html HighBeam]</ref>



==Selected articles==
==Selected articles==
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==References==
==References==
{{reflist}}
{{reflist}}

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==External links==
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* http://biolchem.huji.ac.il/shimons/personal.html
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{{DEFAULTSORT:Schuldiner, Shimon}}
[[Category:1946 births]]
[[Category:Israeli biochemists]]
[[Category:Academic staff of the Hebrew University of Jerusalem]]
[[Category:Hebrew University of Jerusalem alumni]]
[[Category:Argentine emigrants to Israel]]
[[Category:Argentine Jews]]
[[Category:Argentine people of Ukrainian-Jewish descent]]
[[Category:Argentine scientists]]
[[Category:Israeli Jews]]
[[Category:Israeli people of Ukrainian-Jewish descent]]
[[Category:Israeli scientists]]
[[Category:Living people]]
[[Category:Scientists from Buenos Aires]]

Latest revision as of 12:35, 15 July 2024

Shimon Schuldiner
Born
Buenos Aires, Argentina
NationalityIsraeli
Known forResearch of trans-membrane transporters
Scientific career
FieldsBiochemistry
InstitutionsThe Hebrew University of Jerusalem

Shimon Schuldiner (born August 10, 1946) is an Israeli biochemist. He has made important contributions to the understanding of proteins that couple the movement of ions and other molecules across membranes. Schuldiner is Mathilda Marks-Kennedy Professor at the Alexander Silberman Institute of Life Sciences, the Hebrew University of Jerusalem. He received a B.Sc. in 1967 and an M.Sc. in 1968 from the Hebrew University of Jerusalem, and a Ph.D. from the Weizmann Institute of Science in Rehovot in 1973.[1][2]

Biography

[edit]

Schuldiner was born on August 10, 1946, in Buenos Aires, Argentina, to Hana Joszpe and Berko Schuldiner, who were Jewish immigrants from Ukraine. In 1964 he emigrated to Israel, where he has been living since. He earned a B.Sc. in 1967 and a M.Sc. in 1968 from the Hebrew University of Jerusalem, the latter working with Itzhak Ohad. In 1973 he received a Ph.D. for work performed in the laboratory of Mordhay Avron (z"l) [3] at the Weizmann Institute of Science in Rehovot . From 1973 to 1976 he did postdoctoral research in the laboratory of Howard Ronald Kaback at the Roche Institute for Molecular Biology in Nutley, New Jersey. In 1976 he returned to Israel and joined the Department of Molecular Biology at Hadassah Medical School, and in 1990 he moved to the Alexander Silberman Institute of Life Sciences, both at the Hebrew University of Jerusalem. Between 1999 and 2002, he served as Chairman of the Silberman Institute. Schuldiner is married to Monica Schuldiner, with whom he has two children and six grandchildren. He and his wife are long-time supporters of civil rights in Israel and of the advancement of peace. His son Oren[4] and his daughter-in-law Maya Schuldiner [5][6] are also research biologists, working at the Weizmann Institute of Science. His son Ilan is a physiotherapist at Maccabi Health Services and his daughter in law, Hila Zadka, is a researcher at The Israel Center for Disease Control, Israel Ministry of Health.

Career

[edit]

Schuldiner is a world expert in the expression, purification, and characterization of membrane proteins. Specifically, he focuses on the multidrug antiporter EmrE. Investigation of its subunit structure led the Schuldiner Group to propose a dimer of topologically parallel subunits. This led to a long-running controversy over EmrE topology that eventually led Schuldiner to demonstrate that both parallel and antiparallel dimers are functional.[7][8] His work on the Vesicular Monoamine Transporter (VMAT), elucidating its mechanism of action,[9][10] is essential for the development of better drugs for brain disorders.[11]

Selected articles

[edit]
  1. Schuldiner, S., Rottenberg, H., and Avron, M. (1972) Membrane potential as a driving force for ATP synthesis in chloroplasts. FEBS Lett. 28, 173-176
  2. Ramos, S., Schuldiner, S., and Kaback, H. R. (1976) The electrochemical gradient of protons and its relationship to active transport in Escherichia coli membrane vesicles. Proc. Natl. Acad. Sci. USA 73, 1892-1896
  3. Schuldiner, S., and Kaback, H. R. (1975) Membrane Potential and Active Transport in Membrane Vesicles from Escherichia coli. Biochem 14, 5451-5461
  4. Taglicht, D., Padan, E., and Schuldiner, S. (1993) Proton-sodium stoichiometry of NhaA, an electrogenic antiporter from Escherichia coli. J. Biol. Chem. 268, 5382-5387
  5. Schuldiner, S., Shirvan, A., Stern-Bach, Y., Steiner-Mordoch, S., Yelin, R., and Laskar, O. (1994) From bacterial antibiotic resistance to neurotransmitter uptake. A common theme of cell survival. Ann. N. Y. Acad. Sci. 733, 174-184
  6. Yaffe, D., Radestock, S., Shuster, Y., Forrest, L. R., and Schuldiner, S. (2013) Identification of Molecular Hinge Points Mediating Alternating Access in the Vesicular Monoamine Transporter VMAT2. Proceedings of the National Academy of Sciences 110, E1332-E1341
  7. Stern-Bach, Y., Greenberg-Ofrath, N., Flechner, I., and Schuldiner, S. (1990) Identification and Purification of a Functional Amine Transporter from Bovine Chromaffin Granules. J. Biol. Chem. 265, 3961-3966
  8. Yerushalmi, H., Lebendiker, M., and Schuldiner, S. (1995) EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents. J. Biol. Chem. 270, 6856-6863
  9. Nasie, I., Steiner-Mordoch, S., Gold, A., and Schuldiner, S. (2010) Topologically Random Insertion of Emre Supports a Pathway for Evolution of Inverted Repeats in Ion-Coupled Transporters. J. Biol. Chem. 285, 15234-15244
  10. Shuster, Y., Steiner-Mordoch, S., Alon Cudkowicz, N., and Schuldiner, S. (2016) A Transporter Interactome Is Essential for the Acquisition of Antimicrobial Resistance to Antibiotics. PLoS One 11, e0152917

References

[edit]
  1. ^ "HP". Biolchem.huji.ac.il. Retrieved 2016-08-15.
  2. ^ "Shimon Schuldiner: Faculty Member in Neuronal Signaling Mechanisms - F1000Prime". F1000.com. 2013-01-22. Retrieved 2016-08-15.
  3. ^ Gromet-Elhanan, Z. (1992) Journal of Bioenergetics and Biomembranes 24, 520-521
  4. ^ "Home | Oren Schuldiner's Lab". Weizmann.ac.il. 2016-07-27. Retrieved 2016-08-15.
  5. ^ "Maya Schuldiner". Weizmann.ac.il. Retrieved 2016-08-15.
  6. ^ "יוצאות מהמעבדה: המדעניות מביאות את האִמָּהוּת לעבודה - סוף שבוע - הארץ". Haaretz.co.il. 2010-01-20. Retrieved 2016-08-15.
  7. ^ "MPEC : About". Mpec.ucsf.edu. Retrieved 2016-08-15.
  8. ^ Woodall, N. B., Yin, Y., and Bowie, J. U. (2015) Nat Commun 6
  9. ^ "The Up And Down Side Of 'Traffic' In Our Cells". Medical News Today. Retrieved 2016-08-15.
  10. ^ "'Traffic' in our cells works both for and against us | EurekAlert! Science News". Eurekalert.org. 2013-05-01. Retrieved 2016-08-15.
  11. ^ HighBeam
[edit]
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