Valperinol: Difference between revisions

Valperinol
Clinical data
ATC code	None;
Legal status
Legal status	In general: non-regulated;
Identifiers
	IUPAC name (1R,3R,4S,6R,7S,8R,10R)-8-methoxy-10-methyl-3-(1-piperidinylmethyl)-2,9-dioxatricyclo[4.3.1.03,7]decan-4-ol;
CAS Number	64860-67-9 ;
PubChem CID	68849;
ChemSpider	62082;
UNII	580OD29R6M;
CompTox Dashboard (EPA)	DTXSID501024325 ;
Chemical and physical data
Formula	C16H27NO4
Molar mass	297.395 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O1[C@@H](OC)[C@@H]2[C@@]3(O[C@H]1[C@@H]([C@H]2C[C@@H]3O)C)CN4CCCCC4;
	InChI InChI=1S/C16H27NO4/c1-10-11-8-12(18)16(9-17-6-4-3-5-7-17)13(11)15(19-2)20-14(10)21-16/h10-15,18H,3-9H2,1-2H3/t10-,11-,12+,13-,14+,15-,16-/m1/s1; Key:KZSHXABWNBVUTK-GBIHRFPISA-N;

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Latest revision as of 15:57, 24 July 2024

Valperinol (INN; GA 30-905) is a drug which acts as a calcium channel blocker.^[1]^[2] It was patented as a possible sedative, antiepileptic, and/or antiparkinsonian agent, but was never marketed.^[3]

References

^ Thies PW, Asai A, Bán I, David S, Finner E (1984). "[The synthesis of valperinol and various 3-aminomethyl derivatives of 2,9-dioxatricyclo[4,3,1,0(3,7)]decane from didrovaltrate]". Arzneimittel-Forschung (in German). 34 (11): 1460–3. PMID 6543120.
^ Dose M (1984). "[Calcium antagonist properties of valperinol]". Arzneimittel-Forschung (in German). 34 (11): 1464–6. PMID 6098282.
^ Dictionary of Pharmacological Agents Volume 2. CRC Press. 1996-11-21. p. 2104. ISBN 978-0-412-46630-4. Retrieved 22 April 2012.

This article about a heterocyclic compound is a stub. You can help Wikipedia by expanding it.

[pmid6543120-1] Thies PW, Asai A, Bán I, David S, Finner E (1984). "[The synthesis of valperinol and various 3-aminomethyl derivatives of 2,9-dioxatricyclo[4,3,1,0(3,7)]decane from didrovaltrate]". Arzneimittel-Forschung (in German). 34 (11): 1460–3. PMID 6543120.

[pmid6098282-2] Dose M (1984). "[Calcium antagonist properties of valperinol]". Arzneimittel-Forschung (in German). 34 (11): 1464–6. PMID 6098282.

[isbn978-0-412-46630-4-3] Dictionary of Pharmacological Agents Volume 2. CRC Press. 1996-11-21. p. 2104. ISBN 978-0-412-46630-4. Retrieved 22 April 2012.

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[2]

[3]

@@ Line 1: / Line 1: @@
+{{Short description|Chemical compound}}
 {{Drugbox
 | IUPAC_name               = (1''R'',3''R'',4''S'',6''R'',7''S'',8''R'',10''R'')-8-methoxy-10-methyl-3-(1-piperidinylmethyl)-2,9-dioxatricyclo[4.3.1.0<sup>3,7</sup>]decan-4-ol
 | image                    = Valperinol.svg
+| CAS_number_Ref           = {{cascite|correct|CAS}}
 | CAS_number               = 64860-67-9
+| UNII_Ref                 = {{fdacite|correct|FDA}}
+| UNII                     = 580OD29R6M
 | ATC_prefix               = None
 | ATC_suffix               =
@@ Line 21: / Line 26: @@
 }}
-'''Valperinol''' ([[International Nonproprietary Name|INN]]; '''GA 30-905''') is a [[drug]] which acts as a [[calcium channel blocker]].<ref name="pmid6543120">{{cite journal |vauthors=Thies PW, Asai A, Bán I, David S, Finner E | title = [The synthesis of valperinol and various 3-aminomethyl derivatives of 2,9-dioxatricyclo[4,3,1,0(3,7)]decane from didrovaltrate] | language = German | journal = Arzneimittel-Forschung | volume = 34 | issue = 11 | pages = 1460–3 | year = 1984 | pmid = 6543120 | doi = | url = }}</ref><ref name="pmid6098282">{{cite journal | author = Dose M | title = [Calcium antagonist properties of valperinol] | language = German | journal = Arzneimittel-Forschung | volume = 34 | issue = 11 | pages = 1464–6 | year = 1984 | pmid = 6098282 | doi = | url = }}</ref> It was patented as a possible [[sedative]], [[antiepileptic]], and/or [[Management of Parkinson's disease#Medication|antiparkinsonian]] agent, but was never marketed.<ref name="isbn978-0-412-46630-4">{{cite book | title = Dictionary of Pharmacological Agents Volume 2 | url = https://books.google.com/books?id=A0THacd46ZsC&pg=PA2104 | accessdate = 22 April 2012 | publisher = CRC Press | isbn = 978-0-412-46630-4 | page = 2104|date = 1996-11-21}}</ref>
+'''Valperinol''' ([[International Nonproprietary Name|INN]]; '''GA 30-905''') is a [[drug]] which acts as a [[calcium channel blocker]].<ref name="pmid6543120">{{cite journal |vauthors=Thies PW, Asai A, Bán I, David S, Finner E | title = [The synthesis of valperinol and various 3-aminomethyl derivatives of 2,9-dioxatricyclo[4,3,1,0(3,7)]decane from didrovaltrate] | language = de | journal = Arzneimittel-Forschung | volume = 34 | issue = 11 | pages = 1460–3 | year = 1984 | pmid = 6543120 }}</ref><ref name="pmid6098282">{{cite journal | author = Dose M | title = [Calcium antagonist properties of valperinol] | language = de | journal = Arzneimittel-Forschung | volume = 34 | issue = 11 | pages = 1464–6 | year = 1984 | pmid = 6098282 }}</ref> It was patented as a possible [[sedative]], [[antiepileptic]], and/or [[Management of Parkinson's disease#Medication|antiparkinsonian]] agent, but was never marketed.<ref name="isbn978-0-412-46630-4">{{cite book | title = Dictionary of Pharmacological Agents Volume 2 | url = https://books.google.com/books?id=A0THacd46ZsC&pg=PA2104 | access-date = 22 April 2012 | publisher = CRC Press | isbn = 978-0-412-46630-4 | page = 2104|date = 1996-11-21}}</ref>
 == References ==
@@ Line 29: / Line 34: @@
 [[Category:Ethers]]
-[[Category:Piperidines]]
+[[Category:1-Piperidinyl compounds]]
+{{heterocyclic-stub}}