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{{short description|Former life science company}}
{{Infobox company
{{Infobox company
| name = Helicos Biosciences
| name = Helicos Biosciences
| logo =Helicos BioSciences Logo.png
| logo =Helicos BioSciences Logo.png
| traded_as = {{NASDAQ|HLCS}}
| traded_as = {{NASDAQ was|HLCS}}
| industry = Biotechnology
| industry = Biotechnology
| founded = 2003
| founded = 2003
}}
}}


'''Helicos BioSciences Corporation''', {{NASDAQ|HLCS}} was a publicly traded [[life science]] company headquartered in [[Cambridge, Massachusetts]] focused on [[genetic analysis]] technologies for the research, drug discovery and diagnostic markets. The firm's Helicos Genetic Analysis Platform was the first DNA-sequencing instrument to operate by [[Single molecule fluorescent sequencing|imaging individual DNA molecules]]. In May 2010, the company announced a 50% layoff and a re-focusing on molecular diagnostics. After long financial troubles, in November 2010, Helicos was delisted from NASDAQ.<ref>{{cite web| url=http://www.bizjournals.com/boston/blog/mass-high-tech/2010/04/helicos-delisting-notice-sends-shares-falling.html | title=Helicos delisting notice sends shares falling | author= | publisher=Boston Business Journal| accessdate=2013-07-29|date=April 2010}}</ref>
'''Helicos BioSciences Corporation''' was a publicly traded [[life science]] company headquartered in [[Cambridge, Massachusetts]] focused on [[genetic analysis]] technologies for the research, drug discovery and diagnostic markets. The firm's Helicos Genetic Analysis Platform was the first DNA-sequencing instrument to operate by [[Single molecule fluorescent sequencing|imaging individual DNA molecules]]. In May 2010, the company announced a 50% layoff and a re-focusing on molecular diagnostics. After long financial troubles, in November 2010, Helicos was delisted from NASDAQ.<ref>{{cite web| url=http://www.bizjournals.com/boston/blog/mass-high-tech/2010/04/helicos-delisting-notice-sends-shares-falling.html | title=Helicos delisting notice sends shares falling | author= | publisher=Boston Business Journal| accessdate=2013-07-29|date=April 2010}}</ref>


Helicos was co-founded in 2003 by life science entrepreneur Stanley Lapidus, [[Stephen Quake]], and Noubar Afeyan with investments from [[Atlas Venture]], Flagship Ventures, [[Highland Capital Partners]], [[MPM Capital]], and Versant Ventures.
Helicos was co-founded in 2003 by life science entrepreneur Stanley Lapidus, [[Stephen Quake]], and Noubar Afeyan with investments from [[Atlas Venture]], Flagship Ventures, [[Highland Capital Partners]], [[MPM Capital]], and [[Versant Ventures]].


Helicos's technology images the extension of individual DNA molecules using a defined primer and individual fluorescently labeled nucleotides, which contain a "Virtual Terminator" preventing incorporation of multiple nucleotides per cycle. The "Virtual Terminator" technology was developed by Dr. Suhaib Siddiqi,<ref>{{cite web| url=http://www.zsgenetics.com/our-team/ | title=ZS Genetics Team| author= | accessdate=2013-07-29| month= | year=}}</ref><ref>{{cite web| url=http://www.crunchbase.com/person/suhaib-siddiqi | title=CrunchBase| author= | accessdate=2013-07-29| month= | year=}}</ref> while at Helicos Biosciences.<ref>{{cite journal| title=Virtual terminator nucleotides for next-generation DNA sequencing | month= | year=2009 | volume=6 | issue=8 | doi=10.1038/nmeth.1354 | pmid=19620973 | journal=Nature Methods | pages=593–595| pmc=2719685| last1=Bowers | first1=Jayson | last2=Mitchell | first2=Judith | last3=Beer | first3=Eric | last4=Buzby | first4=Philip R. | last5=Causey | first5=Marie | last6=Efcavitch | first6=J William | last7=Jarosz | first7=Mirna | last8=Krzymanska-Olejnik | first8=Edyta | last9=Kung | first9=Li | last10=Lipson | first10=Doron | last11=Lowman | first11=Geoffrey M. | last12=Marappan | first12=Subramanian | last13=McInerney | first13=Peter | last14=Platt | first14=Adam | last15=Roy | first15=Atanu | last16=Siddiqi | first16=Suhaib M. | last17=Steinmann | first17=Kathleen | last18=Thompson | first18=John F. }}</ref><ref>{{cite web| url=http://www.freepatentsonline.com/result.html?p=1&sort=relevance&srch=top&query_txt=Suhaib+Siddiqi&patents=on | title=Helicos Virtual Terminators Patents Search Result| author= | accessdate=2013-07-29| month= | year=}}</ref>
Helicos's technology images the extension of individual DNA molecules using a defined primer and individual fluorescently labeled nucleotides, which contain a "Virtual Terminator" preventing incorporation of multiple nucleotides per cycle. The "Virtual Terminator" technology was developed by Dr. Suhaib Siddiqi,<ref>{{cite web| url=http://www.zsgenetics.com/our-team/| title=ZS Genetics Team| author=| accessdate=2013-07-29| year=| archive-date=2013-10-05| archive-url=https://web.archive.org/web/20131005003430/http://www.zsgenetics.com/our-team/| url-status=dead}}</ref> while at Helicos Biosciences.<ref>{{cite journal| title=Virtual terminator nucleotides for next-generation DNA sequencing | year=2009 | volume=6 | issue=8 | doi=10.1038/nmeth.1354 | pmid=19620973 | journal=Nature Methods | pages=593–595| pmc=2719685| last1=Bowers | first1=Jayson | last2=Mitchell | first2=Judith | last3=Beer | first3=Eric | last4=Buzby | first4=Philip R. | last5=Causey | first5=Marie | last6=Efcavitch | first6=J William | last7=Jarosz | first7=Mirna | last8=Krzymanska-Olejnik | first8=Edyta | last9=Kung | first9=Li | last10=Lipson | first10=Doron | last11=Lowman | first11=Geoffrey M. | last12=Marappan | first12=Subramanian | last13=McInerney | first13=Peter | last14=Platt | first14=Adam | last15=Roy | first15=Atanu | last16=Siddiqi | first16=Suhaib M. | last17=Steinmann | first17=Kathleen | last18=Thompson | first18=John F. }}</ref><ref>{{cite web| url=http://www.freepatentsonline.com/result.html?p=1&sort=relevance&srch=top&query_txt=Suhaib+Siddiqi&patents=on | title=Helicos Virtual Terminators Patents Search Result| author= | accessdate=2013-07-29| year=}}</ref>


In the August 2009 issue of [[Nature Biotechnology]], Dr. Stephen Quake, a professor of bioengineering at [[Stanford University]] and a co-founder of Helicos BioSciences, sequenced his own genome, using Single Molecule Sequencing for under $50,000 in reagents.<ref>{{cite web| url=https://www.wired.com/wiredscience/2009/08/helicos-co-founder-sequences-own-genome-using-single-molecule-technology/ | title=Helicos co-founder sequences own genome using single-molecule technology | author=Daniel MacArthur | publisher=Wired| accessdate=2009-08-10|date=August 2009}}</ref>
In the August 2009 issue of [[Nature Biotechnology]], Dr. Stephen Quake, a professor of bioengineering at [[Stanford University]] and a co-founder of Helicos BioSciences, sequenced his own genome, using Single Molecule Sequencing for under $50,000 in reagents.<ref>{{cite web| url=https://www.wired.com/wiredscience/2009/08/helicos-co-founder-sequences-own-genome-using-single-molecule-technology/ | title=Helicos co-founder sequences own genome using single-molecule technology | author=Daniel MacArthur | publisher=Wired| accessdate=2009-08-10|date=August 2009}}</ref>
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On November 15, 2012, Helicos BioSciences filed for Chapter 11 bankruptcy.<ref>{{cite web|url=http://biz.yahoo.com/e/121115/hlcs8-k.html |title=Helicos Filed Chapter 11 Bankruptcy Form 8-K for HELICOS BIOSCIENCES CORP |publisher=Yahoo Finance |accessdate=2013-07-29 |date=November 2012 |url-status=dead |archiveurl=https://web.archive.org/web/20121121065028/http://biz.yahoo.com/e/121115/hlcs8-k.html |archivedate=2012-11-21 }}</ref>
On November 15, 2012, Helicos BioSciences filed for Chapter 11 bankruptcy.<ref>{{cite web|url=http://biz.yahoo.com/e/121115/hlcs8-k.html |title=Helicos Filed Chapter 11 Bankruptcy Form 8-K for HELICOS BIOSCIENCES CORP |publisher=Yahoo Finance |accessdate=2013-07-29 |date=November 2012 |url-status=dead |archiveurl=https://web.archive.org/web/20121121065028/http://biz.yahoo.com/e/121115/hlcs8-k.html |archivedate=2012-11-21 }}</ref>


The patents that Helicos had licensed from Cal Tech (where Quake was when he made the underlying inventions) were subsequently licensed to Direct Genomics, founded by [[He_Jiankui|Jiankui He]], a former post-doc in Quake's lab who gained notoriety in November 2018 when he created the first germline [[genome editing|genome-edited]] babies.<ref name=AK>{{cite news |last1=Coleman |first1=Zach |title=The businesses behind the doctor who manipulated baby DNA |url=https://asia.nikkei.com/Business/Technology/The-businesses-behind-the-doctor-who-manipulated-baby-DNA |work=Nikkei Asian Review |date=November 27, 2018}}</ref>
The patents that Helicos had licensed from Cal Tech (where Quake was when he made the underlying inventions) were subsequently licensed to Direct Genomics, founded by [[He Jiankui|Jiankui He]], a former post-doc in Quake's lab who gained notoriety in November 2018 when he created the first germline [[genome editing|genome-edited]] babies.<ref name=AK>{{cite news |last1=Coleman |first1=Zach |title=The businesses behind the doctor who manipulated baby DNA |url=https://asia.nikkei.com/Business/Technology/The-businesses-behind-the-doctor-who-manipulated-baby-DNA |work=Nikkei Asian Review |date=November 27, 2018}}</ref>


==See also==
==See also==
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==References==
==References==
{{reflist}}
{{Reflist}}


== External links ==
== External links ==
* [http://www.helicosbio.com Helicos BioSciences Corp.] firm website (Now defunct after Bankruptcy)
* [http://www.helicosbio.com Helicos BioSciences Corp.] firm website (Now defunct after Bankruptcy)

{{Authority control}}


[[Category:Biotechnology companies of the United States]]
[[Category:Biotechnology companies of the United States]]
[[Category:Genomics]]
[[Category:Genomics companies]]
[[Category:2003 establishments in Massachusetts]]
[[Category:Biotechnology companies established in 2003]]
[[Category:Life science companies based in Massachusetts]]
[[Category:Life science companies based in Massachusetts]]
[[Category:Companies based in Cambridge, Massachusetts]]
[[Category:Companies based in Cambridge, Massachusetts]]
[[Category:Insolvent companies]]
[[Category:Companies that filed for Chapter 11 bankruptcy in 2012]]



{{med-company-stub}}
{{med-company-stub}}

Latest revision as of 04:03, 27 July 2024

Helicos Biosciences
Nasdaq: HLCS
IndustryBiotechnology
Founded2003
Headquarters
Cambridge Edit this on Wikidata
,
United States Edit this on Wikidata
Websitewww.helicosbio.com Edit this on Wikidata

Helicos BioSciences Corporation was a publicly traded life science company headquartered in Cambridge, Massachusetts focused on genetic analysis technologies for the research, drug discovery and diagnostic markets. The firm's Helicos Genetic Analysis Platform was the first DNA-sequencing instrument to operate by imaging individual DNA molecules. In May 2010, the company announced a 50% layoff and a re-focusing on molecular diagnostics. After long financial troubles, in November 2010, Helicos was delisted from NASDAQ.[1]

Helicos was co-founded in 2003 by life science entrepreneur Stanley Lapidus, Stephen Quake, and Noubar Afeyan with investments from Atlas Venture, Flagship Ventures, Highland Capital Partners, MPM Capital, and Versant Ventures.

Helicos's technology images the extension of individual DNA molecules using a defined primer and individual fluorescently labeled nucleotides, which contain a "Virtual Terminator" preventing incorporation of multiple nucleotides per cycle. The "Virtual Terminator" technology was developed by Dr. Suhaib Siddiqi,[2] while at Helicos Biosciences.[3][4]

In the August 2009 issue of Nature Biotechnology, Dr. Stephen Quake, a professor of bioengineering at Stanford University and a co-founder of Helicos BioSciences, sequenced his own genome, using Single Molecule Sequencing for under $50,000 in reagents.[5]

On November 15, 2012, Helicos BioSciences filed for Chapter 11 bankruptcy.[6]

The patents that Helicos had licensed from Cal Tech (where Quake was when he made the underlying inventions) were subsequently licensed to Direct Genomics, founded by Jiankui He, a former post-doc in Quake's lab who gained notoriety in November 2018 when he created the first germline genome-edited babies.[7]

See also

[edit]

References

[edit]
  1. ^ "Helicos delisting notice sends shares falling". Boston Business Journal. April 2010. Retrieved 2013-07-29.
  2. ^ "ZS Genetics Team". Archived from the original on 2013-10-05. Retrieved 2013-07-29.
  3. ^ Bowers, Jayson; Mitchell, Judith; Beer, Eric; Buzby, Philip R.; Causey, Marie; Efcavitch, J William; Jarosz, Mirna; Krzymanska-Olejnik, Edyta; Kung, Li; Lipson, Doron; Lowman, Geoffrey M.; Marappan, Subramanian; McInerney, Peter; Platt, Adam; Roy, Atanu; Siddiqi, Suhaib M.; Steinmann, Kathleen; Thompson, John F. (2009). "Virtual terminator nucleotides for next-generation DNA sequencing". Nature Methods. 6 (8): 593–595. doi:10.1038/nmeth.1354. PMC 2719685. PMID 19620973.
  4. ^ "Helicos Virtual Terminators Patents Search Result". Retrieved 2013-07-29.
  5. ^ Daniel MacArthur (August 2009). "Helicos co-founder sequences own genome using single-molecule technology". Wired. Retrieved 2009-08-10.
  6. ^ "Helicos Filed Chapter 11 Bankruptcy Form 8-K for HELICOS BIOSCIENCES CORP". Yahoo Finance. November 2012. Archived from the original on 2012-11-21. Retrieved 2013-07-29.
  7. ^ Coleman, Zach (November 27, 2018). "The businesses behind the doctor who manipulated baby DNA". Nikkei Asian Review.
[edit]


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