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{{Short description|Protein found in humans}}
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{{PBB|geneid=5087}}
{{cs1 config|name-list-style=vanc|display-authors=6}}
'''Pre-B-cell leukemia transcription factor 1''' is a [[protein]] that in humans is encoded by the ''PBX1'' [[gene]].<ref>{{cite web | title = Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5087| accessdate = }}</ref>
{{Infobox_gene}}'''Pre-B-cell leukemia transcription factor 1''' is a [[protein]] that in humans is encoded by the ''PBX1'' [[gene]].<ref>{{cite web | title = Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5087}}</ref> The homologous protein in Drosophila is known as '''extradenticle''', and causes changes in embryonic development.
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==Interactions==
== Function ==
Mice studies suggest PBX1 is involved in bone generation and skeletal patterning.<ref>{{Cite web |title=PBX1 PBX homeobox 1 [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=5087 |access-date=2023-06-11 |website=www.ncbi.nlm.nih.gov}}</ref>
PBX1 has been shown to [[Protein-protein interaction|interact]] with [[HOXB1]],<ref name=pmid9482740>{{cite journal |last=Berthelsen |first=J |authorlink= |coauthors=Zappavigna V, Ferretti E, Mavilio F, Blasi F |year=1998|month=Mar |title=The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity |journal=EMBO J. |volume=17 |issue=5 |pages=1434–45 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 9482740 |doi = 10.1093/emboj/17.5.1434 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1170491 }}</ref><ref name=pmid10052460>{{cite journal |last=Piper |first=D E |authorlink= |coauthors=Batchelor A H, Chang C P, Cleary M L, Wolberger C |year=1999|month=Feb |title=Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation |journal=Cell |volume=96 |issue=4 |pages=587–97 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 10052460 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0092-8674(00)80662-5 }}</ref> [[MEIS1]]<ref name=pmid10082572>{{cite journal |last=Shen |first=W F |authorlink= |coauthors=Rozenfeld S, Kwong A, Köm ves L G, Lawrence H J, Largman C |year=1999|month=Apr |title=HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells |journal=Mol. Cell. Biol. |volume=19 |issue=4 |pages=3051–61 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10082572 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=84099 }}</ref><ref name=pmid10523646>{{cite journal |last=Shanmugam |first=K |authorlink= |coauthors=Green N C, Rambaldi I, Saragovi H U, Featherstone M S |year=1999|month=Nov |title=PBX and MEIS as Non-DNA-Binding Partners in Trimeric Complexes with HOX Proteins |journal=Mol. Cell. Biol. |volume=19 |issue=11 |pages=7577–88 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10523646 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=84774 }}</ref><ref name=pmid10373562>{{cite journal |last=Jacobs |first=Y |authorlink= |coauthors=Schnabel C A, Cleary M L |year=1999|month=Jul |title=Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity |journal=Mol. Cell. Biol. |volume=19 |issue=7 |pages=5134–42 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10373562 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=84356 }}</ref> and [[HOXB7]].<ref name=pmid7729685>{{cite journal |last=Chang |first=C P |authorlink= |coauthors=Shen W F, Rozenfeld S, Lawrence H J, Largman C, Cleary M L |year=1995|month=Mar |title=Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins |journal=Genes Dev. |volume=9 |issue=6 |pages=663–74 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 7729685 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1101/gad.9.6.663 }}</ref>


==References==
== Interactions ==

PBX1 has been shown to [[Protein-protein interaction|interact]] with:
* [[HOXB1]],<ref name = pmid9482740>{{cite journal | vauthors = Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F | title = The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1434–1445 | date = March 1998 | pmid = 9482740 | pmc = 1170491 | doi = 10.1093/emboj/17.5.1434 }}</ref><ref name = pmid10052460>{{cite journal | vauthors = Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C | title = Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation | journal = Cell | volume = 96 | issue = 4 | pages = 587–597 | date = February 1999 | pmid = 10052460 | doi = 10.1016/S0092-8674(00)80662-5 | s2cid = 16122785 | doi-access = free }}</ref>
* [[HOXB7]],<ref name = pmid7729685>{{cite journal | vauthors = Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML | title = Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins | journal = Genes & Development | volume = 9 | issue = 6 | pages = 663–674 | date = March 1995 | pmid = 7729685 | doi = 10.1101/gad.9.6.663 | doi-access = free }}</ref>
* [[MEIS1]],<ref name = pmid10082572>{{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–3061 | date = April 1999 | pmid = 10082572 | pmc = 84099 | doi = 10.1128/MCB.19.4.3051 }}</ref><ref name = pmid10523646>{{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–7588 | date = November 1999 | pmid = 10523646 | pmc = 84774 | doi = 10.1128/MCB.19.11.7577 }}</ref><ref name = pmid10373562>{{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5134–5142 | date = July 1999 | pmid = 10373562 | pmc = 84356 | doi = 10.1128/MCB.19.7.5134 }}</ref> and
* [[PKNOX1|Prep1]].<ref name = pmid16705164>{{cite journal | vauthors = Zubair M, Ishihara S, Oka S, Okumura K, Morohashi K | title = Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1 | journal = Molecular and Cellular Biology | volume = 26 | issue = 11 | pages = 4111–4121 | date = June 2006 | pmid = 16705164 | pmc = 1489093 | doi = 10.1128/MCB.00222-06 }}</ref>

== Fruit fly homolog ==
The [[Drosophila melanogaster|''Drosophila melangoster'']] gene called ''extradenticle'' encodes a homeodomain protein that is 71% similar to the Pbx1 protein, and is considered homologous to PBX1.<ref name=":0">{{cite journal | vauthors = Rauskolb C, Peifer M, Wieschaus E | title = extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1 | journal = Cell | volume = 74 | issue = 6 | pages = 1101–1112 | date = September 1993 | pmid = 8104703 | doi = 10.1016/0092-8674(93)90731-5 | s2cid = 44721382 }}</ref> extradenticle is a [[Homeodomain transcription factors|homeodomain transcription factor]]<ref>{{cite journal | vauthors = Aspland SE, White RA | title = Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout development in Drosophila | journal = Development | volume = 124 | issue = 3 | pages = 741–747 | date = February 1997 | pmid = 9043089 | doi = 10.1242/dev.124.3.741 }}</ref> expressed during [[embryogenesis]] and is related to morphological changes and development.<ref name=":0" />

Reduced levels of extradenticle cause segmental transformations, without affecting the functionality or location of [[Homeotic gene|homeotic]] genes. Complete removal of extradenticle both maternally and zygotically leads to alterations from failure of non-extradenticle protein expression.<ref>{{cite journal | vauthors = Peifer M, Wieschaus E | title = Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity | journal = Genes & Development | volume = 4 | issue = 7 | pages = 1209–1223 | date = July 1990 | pmid = 1976570 | doi = 10.1101/gad.4.7.1209 | doi-access = free }}</ref>

A monoclonal antibody study of the expression of extradenticle protein in embryonic development found that it is uniformly distributed, as well as excluded from cell nuclei, until [[gastrulation]]. During the germ band retraction stage of development, extradenticle protein begins to accumulate in the nuclei of cells in a specific pattern. Proximal areas of wing and leg [[imaginal disc]]s have extradenticle present in the nucleus, while distal areas only have it in the cytoplasm.<ref>{{Cite web |title=Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout development in Drosophila |url=https://journals.biologists.com/dev/article/124/3/741/39722/Nucleocytoplasmic-localisation-of-extradenticle |access-date=2023-06-06 |website=journals.biologists.com}}</ref>

== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
*{{cite journal | author=Sanyal M, Tung JW |title=B-cell development fails in the absence of the Pbx1 proto-oncogene |journal=Blood. |volume=109 |issue= 10 |pages= 4191–9 |year= 2007 |pmid= 17244677 |doi= 10.1182/blood-2006-10-054213 | pmc=1885499}}
* {{cite journal | vauthors = Sanyal M, Tung JW, Karsunky H, Zeng H, Selleri L, Weissman IL, Herzenberg LA, Cleary ML | display-authors = 6 | title = B-cell development fails in the absence of the Pbx1 proto-oncogene | journal = Blood | volume = 109 | issue = 10 | pages = 4191–4199 | date = May 2007 | pmid = 17244677 | pmc = 1885499 | doi = 10.1182/blood-2006-10-054213 }}
* {{cite journal | vauthors = Hui H, Perfetti R | title = Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood | journal = European Journal of Endocrinology | volume = 146 | issue = 2 | pages = 129–141 | date = February 2002 | pmid = 11834421 | doi = 10.1530/eje.0.1460129 | doi-access = free }}
{{PBB_Further_reading
* {{cite journal | vauthors = Hunger SP, Galili N, Carroll AJ, Crist WM, Link MP, Cleary ML | title = The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias | journal = Blood | volume = 77 | issue = 4 | pages = 687–693 | date = February 1991 | pmid = 1671560 | doi = 10.1182/blood.V77.4.687.687 | doi-access = free }}
| citations =
*{{cite journal | author=Hui H, Perfetti R |title=Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood |journal=Eur. J. Endocrinol. |volume=146 |issue= 2 |pages= 129–41 |year= 2002 |pmid= 11834421 |doi=10.1530/eje.0.1460129 }}
* {{cite journal | vauthors = Monica K, Galili N, Nourse J, Saltman D, Cleary ML | title = PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1 | journal = Molecular and Cellular Biology | volume = 11 | issue = 12 | pages = 6149–6157 | date = December 1991 | pmid = 1682799 | pmc = 361792 | doi = 10.1128/mcb.11.12.6149 }}
*{{cite journal | author=Hunger SP, Galili N, Carroll AJ, ''et al.'' |title=The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias |journal=Blood |volume=77 |issue= 4 |pages= 687–93 |year= 1991 |pmid= 1671560 |doi= }}
* {{cite journal | vauthors = Nourse J, Mellentin JD, Galili N, Wilkinson J, Stanbridge E, Smith SD, Cleary ML | title = Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor | journal = Cell | volume = 60 | issue = 4 | pages = 535–545 | date = February 1990 | pmid = 1967982 | doi = 10.1016/0092-8674(90)90657-Z | s2cid = 7975269 | doi-access = free }}
*{{cite journal | author=Monica K, Galili N, Nourse J, ''et al.'' |title=PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1 |journal=Mol. Cell. Biol. |volume=11 |issue= 12 |pages= 6149–57 |year= 1991 |pmid= 1682799 |doi= | pmc=361792 }}
* {{cite journal | vauthors = Kamps MP, Murre C, Sun XH, Baltimore D | title = A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL | journal = Cell | volume = 60 | issue = 4 | pages = 547–555 | date = February 1990 | pmid = 1967983 | doi = 10.1016/0092-8674(90)90658-2 | s2cid = 39661371 }}
*{{cite journal | author=Nourse J, Mellentin JD, Galili N, ''et al.'' |title=Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor |journal=Cell |volume=60 |issue= 4 |pages= 535–45 |year= 1990 |pmid= 1967982 |doi=10.1016/0092-8674(90)90657-Z }}
* {{cite journal | vauthors = Lu Q, Wright DD, Kamps MP | title = Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation | journal = Molecular and Cellular Biology | volume = 14 | issue = 6 | pages = 3938–3948 | date = June 1994 | pmid = 7910944 | pmc = 358760 | doi = 10.1128/mcb.14.6.3938 }}
*{{cite journal | author=Kamps MP, Murre C, Sun XH, Baltimore D |title=A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL |journal=Cell |volume=60 |issue= 4 |pages= 547–55 |year= 1990 |pmid= 1967983 |doi=10.1016/0092-8674(90)90658-2 }}
* {{cite journal | vauthors = Van Dijk MA, Voorhoeve PM, Murre C | title = Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 13 | pages = 6061–6065 | date = July 1993 | pmid = 8327485 | pmc = 46867 | doi = 10.1073/pnas.90.13.6061 | doi-access = free | bibcode = 1993PNAS...90.6061D }}
*{{cite journal | author=Lu Q, Wright DD, Kamps MP |title=Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation |journal=Mol. Cell. Biol. |volume=14 |issue= 6 |pages= 3938–48 |year= 1994 |pmid= 7910944 |doi= | pmc=358760 }}
* {{cite journal | vauthors = Lu Q, Kamps MP | title = Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex | journal = Molecular and Cellular Biology | volume = 16 | issue = 4 | pages = 1632–1640 | date = April 1996 | pmid = 8657138 | pmc = 231149 | doi = 10.1128/mcb.16.4.1632 }}
*{{cite journal | author=Van Dijk MA, Voorhoeve PM, Murre C |title=Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 13 |pages= 6061–5 |year= 1993 |pmid= 8327485 |doi=10.1073/pnas.90.13.6061 | pmc=46867 }}
* {{cite journal | vauthors = Berthelsen J, Zappavigna V, Mavilio F, Blasi F | title = Prep1, a novel functional partner of Pbx proteins | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1423–1433 | date = March 1998 | pmid = 9482739 | pmc = 1170490 | doi = 10.1093/emboj/17.5.1423 }}
*{{cite journal | author=Lu Q, Kamps MP |title=Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex |journal=Mol. Cell. Biol. |volume=16 |issue= 4 |pages= 1632–40 |year= 1996 |pmid= 8657138 |doi= | pmc=231149 }}
* {{cite journal | vauthors = Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F | title = The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1434–1445 | date = March 1998 | pmid = 9482740 | pmc = 1170491 | doi = 10.1093/emboj/17.5.1434 }}
*{{cite journal | author=Berthelsen J, Zappavigna V, Mavilio F, Blasi F |title=Prep1, a novel functional partner of Pbx proteins |journal=EMBO J. |volume=17 |issue= 5 |pages= 1423–33 |year= 1998 |pmid= 9482739 |doi= 10.1093/emboj/17.5.1423 | pmc=1170490 }}
* {{cite journal | vauthors = Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C | title = Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation | journal = Cell | volume = 96 | issue = 4 | pages = 587–597 | date = February 1999 | pmid = 10052460 | doi = 10.1016/S0092-8674(00)80662-5 | s2cid = 16122785 | doi-access = free }}
*{{cite journal | author=Berthelsen J, Zappavigna V, Ferretti E, ''et al.'' |title=The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity |journal=EMBO J. |volume=17 |issue= 5 |pages= 1434–45 |year= 1998 |pmid= 9482740 |doi= 10.1093/emboj/17.5.1434 | pmc=1170491 }}
* {{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–3061 | date = April 1999 | pmid = 10082572 | pmc = 84099 | doi = 10.1128/MCB.19.4.3051 }}
*{{cite journal | author=Piper DE, Batchelor AH, Chang CP, ''et al.'' |title=Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation |journal=Cell |volume=96 |issue= 4 |pages= 587–97 |year= 1999 |pmid= 10052460 |doi=10.1016/S0092-8674(00)80662-5 }}
* {{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5134–5142 | date = July 1999 | pmid = 10373562 | pmc = 84356 | doi = 10.1128/MCB.19.7.5134 }}
*{{cite journal | author=Shen WF, Rozenfeld S, Kwong A, ''et al.'' |title=HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 3051–61 |year= 1999 |pmid= 10082572 |doi= | pmc=84099 }}
* {{cite journal | vauthors = Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP | display-authors = 6 | title = A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1 | journal = Nucleic Acids Research | volume = 27 | issue = 18 | pages = 3752–3761 | date = September 1999 | pmid = 10471746 | pmc = 148632 | doi = 10.1093/nar/27.18.3752 }}
*{{cite journal | author=Jacobs Y, Schnabel CA, Cleary ML |title=Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5134–42 |year= 1999 |pmid= 10373562 |doi= | pmc=84356 }}
* {{cite journal | vauthors = McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C | title = Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 20 | pages = 11464–11469 | date = September 1999 | pmid = 10500199 | pmc = 18056 | doi = 10.1073/pnas.96.20.11464 | doi-access = free | bibcode = 1999PNAS...9611464M }}
*{{cite journal | author=Knoepfler PS, Bergstrom DA, Uetsuki T, ''et al.'' |title=A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1 |journal=Nucleic Acids Res. |volume=27 |issue= 18 |pages= 3752–61 |year= 1999 |pmid= 10471746 |doi=10.1093/nar/27.18.3752 | pmc=148632 }}
* {{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–7588 | date = November 1999 | pmid = 10523646 | pmc = 84774 | doi = 10.1128/MCB.19.11.7577 }}
*{{cite journal | author=McWhirter JR, Neuteboom ST, Wancewicz EV, ''et al.'' |title=Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11464–9 |year= 1999 |pmid= 10500199 |doi=10.1073/pnas.96.20.11464 | pmc=18056 }}
* {{cite journal | vauthors = Mikkola I, Bruun JA, Holm T, Johansen T | title = Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins | journal = The Journal of Biological Chemistry | volume = 276 | issue = 6 | pages = 4109–4118 | date = February 2001 | pmid = 11069920 | doi = 10.1074/jbc.M008882200 | doi-access = free }}
*{{cite journal | author=Shanmugam K, Green NC, Rambaldi I, ''et al.'' |title=PBX and MEIS as Non-DNA-Binding Partners in Trimeric Complexes with HOX Proteins |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7577–88 |year= 1999 |pmid= 10523646 |doi= | pmc=84774 }}
* {{cite journal | vauthors = Thameem F, Wolford JK, Bogardus C, Prochazka M | title = Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1518 | issue = 1–2 | pages = 215–220 | date = March 2001 | pmid = 11267683 | doi = 10.1016/S0167-4781(01)00189-0 }}
*{{cite journal | author=Mikkola I, Bruun JA, Holm T, Johansen T |title=Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins |journal=J. Biol. Chem. |volume=276 |issue= 6 |pages= 4109–18 |year= 2001 |pmid= 11069920 |doi= 10.1074/jbc.M008882200 }}
* {{cite journal | vauthors = Liu Y, MacDonald RJ, Swift GH | title = DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 17985–17993 | date = May 2001 | pmid = 11279116 | doi = 10.1074/jbc.M100678200 | doi-access = free }}
*{{cite journal | author=Thameem F, Wolford JK, Bogardus C, Prochazka M |title=Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians |journal=Biochim. Biophys. Acta |volume=1518 |issue= 1–2 |pages= 215–20 |year= 2001 |pmid= 11267683 |doi= 10.1016/S0167-4781(01)00189-0}}
* {{cite journal | vauthors = Mal A, Sturniolo M, Schiltz RL, Ghosh MK, Harter ML | title = A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program | journal = The EMBO Journal | volume = 20 | issue = 7 | pages = 1739–1753 | date = April 2001 | pmid = 11285237 | pmc = 145490 | doi = 10.1093/emboj/20.7.1739 }}
*{{cite journal | author=Liu Y, MacDonald RJ, Swift GH |title=DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 17985–93 |year= 2001 |pmid= 11279116 |doi= 10.1074/jbc.M100678200 }}
*{{cite journal | author=Mal A, Sturniolo M, Schiltz RL, ''et al.'' |title=A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program |journal=EMBO J. |volume=20 |issue= 7 |pages= 1739–53 |year= 2001 |pmid= 11285237 |doi= 10.1093/emboj/20.7.1739 | pmc=145490 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5087}}


== External links ==
== External links ==
* {{MeshName|PBX1+protein,+human}}
* {{MeshName|PBX1+protein,+human}}
* {{PDBe-KB2|P40424|Human Pre-B-cell leukemia transcription factor 1}}
* {{PDBe-KB2|P41778|Mouse Pre-B-cell leukemia transcription factor 1}}


⚫
{{PDB Gallery|geneid=5087}}
{{Transcription factors|g3}}
{{Transcription factors|g3}}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]


{{gene-1-stub}}

Latest revision as of 08:41, 5 August 2024

PBX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPBX1, PBX homeobox 1, CAKUHED
External IDsOMIM: 176310; MGI: 97495; HomoloGene: 20574; GeneCards: PBX1; OMA:PBX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5087

18514

Ensembl

ENSG00000185630

ENSMUSG00000052534

UniProt

P40424

P41778

RefSeq (mRNA)

NM_001204961
NM_001204963
NM_002585
NM_001353130
NM_001353131

NM_001291508
NM_001291509
NM_008783
NM_183355

RefSeq (protein)

NP_001191890
NP_001191892
NP_002576
NP_001340059
NP_001340060

NP_001278437
NP_001278438
NP_032809
NP_899198

Location (UCSC)Chr 1: 164.56 – 164.9 MbChr 1: 167.95 – 168.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.[5] The homologous protein in Drosophila is known as extradenticle, and causes changes in embryonic development.

Function

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Mice studies suggest PBX1 is involved in bone generation and skeletal patterning.[6]

Interactions

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PBX1 has been shown to interact with:

Fruit fly homolog

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The Drosophila melangoster gene called extradenticle encodes a homeodomain protein that is 71% similar to the Pbx1 protein, and is considered homologous to PBX1.[14] extradenticle is a homeodomain transcription factor[15] expressed during embryogenesis and is related to morphological changes and development.[14]

Reduced levels of extradenticle cause segmental transformations, without affecting the functionality or location of homeotic genes. Complete removal of extradenticle both maternally and zygotically leads to alterations from failure of non-extradenticle protein expression.[16]

A monoclonal antibody study of the expression of extradenticle protein in embryonic development found that it is uniformly distributed, as well as excluded from cell nuclei, until gastrulation. During the germ band retraction stage of development, extradenticle protein begins to accumulate in the nuclei of cells in a specific pattern. Proximal areas of wing and leg imaginal discs have extradenticle present in the nucleus, while distal areas only have it in the cytoplasm.[17]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185630 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052534 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1".
  6. ^ "PBX1 PBX homeobox 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-06-11.
  7. ^ Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (March 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". The EMBO Journal. 17 (5): 1434–1445. doi:10.1093/emboj/17.5.1434. PMC 1170491. PMID 9482740.
  8. ^ Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (February 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–597. doi:10.1016/S0092-8674(00)80662-5. PMID 10052460. S2CID 16122785.
  9. ^ Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes & Development. 9 (6): 663–674. doi:10.1101/gad.9.6.663. PMID 7729685.
  10. ^ Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (April 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–3061. doi:10.1128/MCB.19.4.3051. PMC 84099. PMID 10082572.
  11. ^ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (November 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–7588. doi:10.1128/MCB.19.11.7577. PMC 84774. PMID 10523646.
  12. ^ Jacobs Y, Schnabel CA, Cleary ML (July 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–5142. doi:10.1128/MCB.19.7.5134. PMC 84356. PMID 10373562.
  13. ^ Zubair M, Ishihara S, Oka S, Okumura K, Morohashi K (June 2006). "Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1". Molecular and Cellular Biology. 26 (11): 4111–4121. doi:10.1128/MCB.00222-06. PMC 1489093. PMID 16705164.
  14. ^ a b Rauskolb C, Peifer M, Wieschaus E (September 1993). "extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1". Cell. 74 (6): 1101–1112. doi:10.1016/0092-8674(93)90731-5. PMID 8104703. S2CID 44721382.
  15. ^ Aspland SE, White RA (February 1997). "Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout development in Drosophila". Development. 124 (3): 741–747. doi:10.1242/dev.124.3.741. PMID 9043089.
  16. ^ Peifer M, Wieschaus E (July 1990). "Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity". Genes & Development. 4 (7): 1209–1223. doi:10.1101/gad.4.7.1209. PMID 1976570.
  17. ^ "Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout development in Drosophila". journals.biologists.com. Retrieved 2023-06-06.

Further reading

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