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{{Short description|American genetic sequencing company}}
[[Image:Celera Genomics logo.png|300px|right]]
{{Infobox company
| name = Celera Corporation
| logo = Celera Genomics logo.png
| logo_size = 150px
| type = [[Subsidiary]]
| traded_as = {{NASDAQ was|CRA}}
| caption =
| foundation = {{start date and age|1998}}
| location = [[Alameda, California]], United States
| key_people = {{ubl|William G. Green ([[chairman]])|Kathy P Ordonez ([[President (corporate title)|president]])}}
| num_employees = 554<ref name=zenobank>{{cite web |url=http://www.zenobank.com/index.php?symbol=CRA&page=quotesearch |title=Company Profile for Celera Group (CRA) |access-date=2008-10-22 |archive-url=https://web.archive.org/web/20111116080440/http://www.zenobank.com/index.php?symbol=CRA&page=quotesearch |archive-date=2011-11-16 |url-status=dead }}</ref>
| parent = [[Quest Diagnostics]]
| industry = Technology
| products = Scientific & Technical Instruments
| owner =
| revenue =
| homepage = {{url|http://www.celera.com}}
}}


'''Celera Corporation''' is a subsidiary of [[Quest Diagnostics]] which focuses on genetic sequencing and related technologies. It was founded in 1998 as a business unit of [[Applera]], spun off into an independent company in 2008, and finally acquired by [[Quest Diagnostics]] in 2011.<ref>https://www.celera.com/celera/pr_1305673632 {{Webarchive|url=https://web.archive.org/web/20110709051849/https://www.celera.com/celera/pr_1305673632 |date=2011-07-09 }} Quest Diagnostics Successfully Completes Acquisition of Celera, May 17, 2011.</ref>
'''Celera Genomics''' ({{nyse|CRA}}) is a business unit of the [[Applera Corporation]] that focuses on genetic sequencing and related technologies. It was established in [[May 1998|May]] [[1998]] by the [[Perkin-Elmer Corporation]] (and was later purchased by Applera), with Dr. J. [[Craig Venter]] from [[The Institute for Genomic Research]] (TIGR) as its first president. While at TIGR, Venter and [[Hamilton Smith]] led the first successful effort to [[sequencing|sequence]] an entire organism's [[genome]], that of the ''Haemophilus influenzae'' [[bacterium]]. Celera was formed for the purpose of generating and commercializing genomic information to accelerate the understanding of biological processes. Its stock is a [[tracking stock]] of Applera, along with the tracking stock of Applera's larger Applied Biosystems Group business unit.


==History==
Celera Genomics researchers were among the first to show the feasibility of the [[whole genome shotgun]] strategy for sequencing large [[Eukaryote|eukaryotic]] genomes. The strategy was already in widespread use for smaller prokaryotic genomes, which include bacteria and archaea. This strategy contrasted with the publicly funded [[Human Genome Project]], which used a slower but safer [[clone by clone sequencing]] strategy. Celera sequenced the human genome at a fraction of the cost of the public project (approximately $3 billion of taxpayer dollars versus about $300 million of private funding); however, its effort was tarnished when they published their results in 2001, because they combined their data with the public data, making it impossible to tell how much of the human genome had been independently sequenced by Celera. In addition, Celera was able to take advantage of the 10 years of publicly funded development of human genome maps and sequences that preceded its formation. Nonetheless, Celera's use of the shotgun strategy spurred the public HGP to change its own strategy, leading to a rapid acceleration of the public effort.
Originally headquartered in [[Rockville, Maryland|Rockville]], [[Maryland]] (relocated to [[Alameda, California]]), it was established in May 1998 by PE Corporation (later renamed to [[Applera]]), with Dr. J. [[Craig Venter]] from [[The Institute for Genomic Research]] (TIGR) as its first president. While at TIGR, Venter and [[Hamilton O. Smith|Hamilton Smith]] led the first successful effort to [[sequencing|sequence]] an entire organism's [[genome]], that of the ''[[Haemophilus influenzae]]'' [[bacterium]]. Celera was formed for the purpose of generating and commercializing genomic information. Its stock is a [[tracking stock]] of Applera, along with the tracking stock of Applera's larger [[Applied Biosystems]] Group business unit.


Celera sequenced the human genome at a fraction of the cost of the publicly funded [[Human Genome Project]] (HGP), using about $300 million of private funding versus approximately $3 billion of taxpayer dollars.{{citation needed|date=December 2022}} However, a significant portion of the human genome had already been sequenced when Celera entered the field, and thus Celera did not incur any costs with obtaining the existing data, which was freely available to the public from [[GenBank]]. Celera's approach, which used [[shotgun sequencing]], spurred the public HGP to accelerate its effort and shift its projected timetable from 2005 to 2003.{{Citation needed|date=January 2020}}
Critics of initial efforts by Celera Genomics to hold back data from sections of genome they sequenced for commercial exploitation felt that it would retard progress in science as a whole. These critics pointed to the [[open access]] policy for gene sequences from the publicly funded Human Genome Project. Later, the company changed their policy and made their sequences available for non-commercial use, but set a maximum threshold for amount of sequence data a researcher could download at any given time.


Critics of initial efforts by Celera Genomics to hold back data from sections of genome they sequenced for commercial exploitation felt that it would retard progress in science as a whole. These critics pointed to the [[Open access (publishing)|open access]] policy for gene sequences from the publicly funded Human Genome Project.<ref>{{cite journal |last1=Yamey |first1=G. |title=Dispute as rival groups publish details of human genome |journal=BMJ |date=17 February 2001 |volume=322 |issue=7283 |pages=381 |id={{Gale|A71350527}} {{ProQuest|1777608398}} |doi=10.1136/bmj.322.7283.381 |pmc=1119622 }}</ref> Later, the company changed their policy and made their sequences available for non-commercial use but set a maximum threshold for amount of sequence data that a researcher could download at any given time.{{Citation needed|date=January 2020}}
The rise and fall of Celera as an ambitious competitor of the [[Human Genome Project]] is the main subject of the book [[The Genome War]] by [[James Shreeve]], who takes a strong pro-Venter point of view. (He followed Venter around for two years in the process of writing the book.) A view from the public effort's side is that of [[Nobel laureate]] Sir [[John Sulston]] in his book ''The Common Thread: A Story of Science, Politics, Ethics and the Human Genome''.

The rise and fall of Celera as an ambitious competitor of the Human Genome Project is the main subject of the book ''The Genome War'' by James Shreeve, who followed Venter around for two years in the process of writing the book. A view from the public effort's side is that of [[Nobel laureate]] Sir [[John Sulston]] in his book ''The Common Thread: A Story of Science, Politics, Ethics and the Human Genome''. Anthropologist Paul Rabinow also based his 2005 book ''A Machine to Make a Future'' on Celera.


==Genomes sequenced by Celera Genomics==
==Genomes sequenced by Celera Genomics==
'''[[Eukaryotes]]''':
* ''[[Drosophila melanogaster]]'' (fruit fly)
* [[Human]],<ref name="Venter">{{cite journal |display-authors=3 |last1=Venter |first1=J. Craig |last2=Adams |first2=Mark D. |last3=Myers |first3=Eugene W. |last4=Li |first4=Peter W. |last5=Mural |first5=Richard J. |last6=Sutton |first6=Granger G. |last7=Smith |first7=Hamilton O. |last8=Yandell |first8=Mark |last9=Evans |first9=Cheryl A. |last10=Holt |first10=Robert A. |last11=Gocayne |first11=Jeannine D. |last12=Amanatides |first12=Peter |last13=Ballew |first13=Richard M. |last14=Huson |first14=Daniel H. |last15=Wortman |first15=Jennifer Russo |last16=Zhang |first16=Qing |last17=Kodira |first17=Chinnappa D. |last18=Zheng |first18=Xiangqun H. |last19=Chen |first19=Lin |last20=Skupski |first20=Marian |last21=Subramanian |first21=Gangadharan |last22=Thomas |first22=Paul D. |last23=Zhang |first23=Jinghui |last24=Gabor Miklos |first24=George L. |last25=Nelson |first25=Catherine |last26=Broder |first26=Samuel |last27=Clark |first27=Andrew G. |last28=Nadeau |first28=Joe |last29=McKusick |first29=Victor A. |last30=Zinder |first30=Norton |last31=Levine |first31=Arnold J. |last32=Roberts |first32=Richard J. |last33=Simon |first33=Mel |last34=Slayman |first34=Carolyn |last35=Hunkapiller |first35=Michael |last36=Bolanos |first36=Randall |last37=Delcher |first37=Arthur |last38=Dew |first38=Ian |last39=Fasulo |first39=Daniel |last40=Flanigan |first40=Michael |last41=Florea |first41=Liliana |last42=Halpern |first42=Aaron |last43=Hannenhalli |first43=Sridhar |last44=Kravitz |first44=Saul |last45=Levy |first45=Samuel |last46=Mobarry |first46=Clark |last47=Reinert |first47=Knut |last48=Remington |first48=Karin |last49=Abu-Threideh |first49=Jane |last50=Beasley |first50=Ellen |last51=Biddick |first51=Kendra |last52=Bonazzi |first52=Vivien |last53=Brandon |first53=Rhonda |last54=Cargill |first54=Michele |last55=Chandramouliswaran |first55=Ishwar |last56=Charlab |first56=Rosane |last57=Chaturvedi |first57=Kabir |last58=Deng |first58=Zuoming |last59=Francesco |first59=Valentina Di |last60=Dunn |first60=Patrick |last61=Eilbeck |first61=Karen |last62=Evangelista |first62=Carlos |last63=Gabrielian |first63=Andrei E. |last64=Gan |first64=Weiniu |last65=Ge |first65=Wangmao |last66=Gong |first66=Fangcheng |last67=Gu |first67=Zhiping |last68=Guan |first68=Ping |last69=Heiman |first69=Thomas J. |last70=Higgins |first70=Maureen E. |last71=Ji |first71=Rui-Ru |last72=Ke |first72=Zhaoxi |last73=Ketchum |first73=Karen A. |last74=Lai |first74=Zhongwu |last75=Lei |first75=Yiding |last76=Li |first76=Zhenya |last77=Li |first77=Jiayin |last78=Liang |first78=Yong |last79=Lin |first79=Xiaoying |last80=Lu |first80=Fu |last81=Merkulov |first81=Gennady V. |last82=Milshina |first82=Natalia |last83=Moore |first83=Helen M. |last84=Naik |first84=Ashwinikumar K |last85=Narayan |first85=Vaibhav A. |last86=Neelam |first86=Beena |last87=Nusskern |first87=Deborah |last88=Rusch |first88=Douglas B. |last89=Salzberg |first89=Steven |last90=Shao |first90=Wei |last91=Shue |first91=Bixiong |last92=Sun |first92=Jingtao |last93=Wang |first93=Zhen Yuan |last94=Wang |first94=Aihui |last95=Wang |first95=Xin |last96=Wang |first96=Jian |last97=Wei |first97=Ming-Hui |last98=Wides |first98=Ron |last99=Xiao |first99=Chunlin |last100=Yan |first100=Chunhua |last101=Yao |first101=Alison |last102=Ye |first102=Jane |last103=Zhan |first103=Ming |last104=Zhang |first104=Weiqing |last105=Zhang |first105=Hongyu |last106=Zhao |first106=Qi |last107=Zheng |first107=Liansheng |last108=Zhong |first108=Fei |last109=Zhong |first109=Wenyan |last110=Zhu |first110=Shiaoping C. |last111=Zhao |first111=Shaying |last112=Gilbert |first112=Dennis |last113=Baumhueter |first113=Suzanna |last114=Spier |first114=Gene |last115=Carter |first115=Christine |last116=Cravchik |first116=Anibal |last117=Woodage |first117=Trevor |last118=Ali |first118=Feroze |last119=An |first119=Huijin |last120=Awe |first120=Aderonke |last121=Baldwin |first121=Danita |last122=Baden |first122=Holly |last123=Barnstead |first123=Mary |last124=Barrow |first124=Ian |last125=Beeson |first125=Karen |last126=Busam |first126=Dana |last127=Carver |first127=Amy |last128=Center |first128=Angela |last129=Cheng |first129=Ming Lai |last130=Curry |first130=Liz |last131=Danaher |first131=Steve |last132=Davenport |first132=Lionel |last133=Desilets |first133=Raymond |last134=Dietz |first134=Susanne |last135=Dodson |first135=Kristina |last136=Doup |first136=Lisa |last137=Ferriera |first137=Steven |last138=Garg |first138=Neha |last139=Gluecksmann |first139=Andres |last140=Hart |first140=Brit |last141=Haynes |first141=Jason |last142=Haynes |first142=Charles |last143=Heiner |first143=Cheryl |last144=Hladun |first144=Suzanne |last145=Hostin |first145=Damon |last146=Houck |first146=Jarrett |last147=Howland |first147=Timothy |last148=Ibegwam |first148=Chinyere |last149=Johnson |first149=Jeffery |last150=Kalush |first150=Francis |last151=Kline |first151=Lesley |last152=Koduru |first152=Shashi |last153=Love |first153=Amy |last154=Mann |first154=Felecia |last155=May |first155=David |last156=McCawley |first156=Steven |last157=McIntosh |first157=Tina |last158=McMullen |first158=Ivy |last159=Moy |first159=Mee |last160=Moy |first160=Linda |last161=Murphy |first161=Brian |last162=Nelson |first162=Keith |last163=Pfannkoch |first163=Cynthia |last164=Pratts |first164=Eric |last165=Puri |first165=Vinita |last166=Qureshi |first166=Hina |last167=Reardon |first167=Matthew |last168=Rodriguez |first168=Robert |last169=Rogers |first169=Yu-Hui |last170=Romblad |first170=Deanna |last171=Ruhfel |first171=Bob |last172=Scott |first172=Richard |last173=Sitter |first173=Cynthia |last174=Smallwood |first174=Michelle |last175=Stewart |first175=Erin |last176=Strong |first176=Renee |last177=Suh |first177=Ellen |last178=Thomas |first178=Reginald |last179=Tint |first179=Ni Ni |last180=Tse |first180=Sukyee |last181=Vech |first181=Claire |last182=Wang |first182=Gary |last183=Wetter |first183=Jeremy |last184=Williams |first184=Sherita |last185=Williams |first185=Monica |last186=Windsor |first186=Sandra |last187=Winn-Deen |first187=Emily |last188=Wolfe |first188=Keriellen |last189=Zaveri |first189=Jayshree |last190=Zaveri |first190=Karena |last191=Abril |first191=Josep F. |last192=Guigó |first192=Roderic |last193=Campbell |first193=Michael J. |last194=Sjolander |first194=Kimmen V. |last195=Karlak |first195=Brian |last196=Kejariwal |first196=Anish |last197=Mi |first197=Huaiyu |last198=Lazareva |first198=Betty |last199=Hatton |first199=Thomas |last200=Narechania |first200=Apurva |last201=Diemer |first201=Karen |last202=Muruganujan |first202=Anushya |last203=Guo |first203=Nan |last204=Sato |first204=Shinji |last205=Bafna |first205=Vineet |last206=Istrail |first206=Sorin |last207=Lippert |first207=Ross |last208=Schwartz |first208=Russell |last209=Walenz |first209=Brian |last210=Yooseph |first210=Shibu |last211=Allen |first211=David |last212=Basu |first212=Anand |last213=Baxendale |first213=James |last214=Blick |first214=Louis |last215=Caminha |first215=Marcelo |last216=Carnes-Stine |first216=John |last217=Caulk |first217=Parris |last218=Chiang |first218=Yen-Hui |last219=Coyne |first219=My |last220=Dahlke |first220=Carl |last221=Mays |first221=Anne Deslattes |last222=Dombroski |first222=Maria |last223=Donnelly |first223=Michael |last224=Ely |first224=Dale |last225=Esparham |first225=Shiva |last226=Fosler |first226=Carl |last227=Gire |first227=Harold |last228=Glanowski |first228=Stephen |last229=Glasser |first229=Kenneth |last230=Glodek |first230=Anna |last231=Gorokhov |first231=Mark |last232=Graham |first232=Ken |last233=Gropman |first233=Barry |last234=Harris |first234=Michael |last235=Heil |first235=Jeremy |last236=Henderson |first236=Scott |last237=Hoover |first237=Jeffrey |last238=Jennings |first238=Donald |last239=Jordan |first239=Catherine |last240=Jordan |first240=James |last241=Kasha |first241=John |last242=Kagan |first242=Leonid |last243=Kraft |first243=Cheryl |last244=Levitsky |first244=Alexander |last245=Lewis |first245=Mark |last246=Liu |first246=Xiangjun |last247=Lopez |first247=John |last248=Ma |first248=Daniel |last249=Majoros |first249=William |last250=McDaniel |first250=Joe |last251=Murphy |first251=Sean |last252=Newman |first252=Matthew |last253=Nguyen |first253=Trung |last254=Nguyen |first254=Ngoc |last255=Nodell |first255=Marc |last256=Pan |first256=Sue |last257=Peck |first257=Jim |last258=Peterson |first258=Marshall |last259=Rowe |first259=William |last260=Sanders |first260=Robert |last261=Scott |first261=John |last262=Simpson |first262=Michael |last263=Smith |first263=Thomas |last264=Sprague |first264=Arlan |last265=Stockwell |first265=Timothy |last266=Turner |first266=Russell |last267=Venter |first267=Eli |last268=Wang |first268=Mei |last269=Wen |first269=Meiyuan |last270=Wu |first270=David |last271=Wu |first271=Mitchell |last272=Xia |first272=Ashley |last273=Zandieh |first273=Ali |last274=Zhu |first274=Xiaohong |title=The Sequence of the Human Genome |journal=Science |date=16 February 2001 |volume=291 |issue=5507 |pages=1304–1351 |doi=10.1126/science.1058040 |pmid=11181995 |bibcode=2001Sci...291.1304V |doi-access=free }}</ref> specifically mostly that of [[Craig Venter]]<ref>{{cite magazine|url=https://www.technologyreview.com/s/408606/craig-venters-genome/|last=Singer|first=Emily|date=2007-09-04|title=Craig Venter's Genome|magazine=[[MIT Technology Review]]|quote=Five years ago, Craig Venter let out a big secret. As president of Celera Genomics, Venter had led the race between his company and a government-funded project to decode the human genome. After leaving Celera in 2002, Venter announced that much of the genome that had been sequenced there was his own.}}</ref>
* ''[[Anopheles gambiae]]'' (mosquito)
* [[Mouse]]<ref>[https://www.handelsblatt.com/archiv/celera-genomics-entschluesselt-erbgut-der-maus;337192/ Newspaperarticle from "Handelsblatt", 2000-10-12]</ref>


== References ==
Eukaryotes:
{{Reflist}}
*[[Drosophila melanogaster]] (fruit fly)
*[[Human genome]]
*[[Mouse genome]]


==Further reading==
== External links==
* {{cite book |doi=10.1163/9789004392137_011 |chapter=Living with the Genome, by Angus Clark and Flo Ticehurst, within the Muslim Context |title=Islamic Ethics and the Genome Question |date=2019 |last1=Shabana |first1=Ayman |pages=241–249 |isbn=978-90-04-39212-0 }}
*[http://www.celera.com/ Celera Genomics website]
* {{cite journal |last1=Norman |first1=Peter |title=Celera Genomics |journal=Expert Opinion on Therapeutic Patents |date=September 2004 |volume=14 |issue=9 |pages=1345–1349 |doi=10.1517/13543776.14.9.1345 }}
*[http://clinton4.nara.gov/WH/EOP/OSTP/html/00626_4.html Prepared Statement of Craig Venter of Celera] Venter discusses Celera's progress in deciphering the human genome sequence and its relationship to healthcare and to the federally funded Human Genome Project.

*[http://www.applera.com/ Applera Corporation website]
==External links==
*[http://www.zacks.com/research/report.php?t=abi&type=main&x=0&y=0/ Zacks Investment Research]
*[http://www.celera.com/ Company website]
*[https://web.archive.org/web/20110514175551/http://clinton4.nara.gov/WH/EOP/OSTP/html/00626_4.html Prepared Statement of Craig Venter of Celera] Venter discusses Celera's progress in deciphering the human genome sequence and its relationship to healthcare and to the federally funded Human Genome Project.
*[http://www.genome.gov/ U.S. National Institutes of Health website for the Human Genome Research Institute]
*[http://www.genome.gov/ U.S. National Institutes of Health website for the Human Genome Research Institute]


{{Authority control}}
[[Category:Companies based in Maryland]]
[[Category:Research support companies]]


[[Category:Research support companies]]
[[de:Celera Genomics]]
[[Category:Companies formerly listed on the Nasdaq]]
[[es:Celera Genomics]]
[[Category:Companies based in Alameda, California]]
[[fr:Celera Genomics]]
[[Category:Life sciences industry]]
[[it:Celera Genomics]]
[[Category:Biotechnology companies established in 1998]]
[[hu:Celera Genomics]]
[[Category:1998 establishments in Maryland]]
[[tr:Celera]]
[[Category:Biotechnology companies of the United States]]
[[Category:2011 mergers and acquisitions]]

Latest revision as of 16:41, 11 August 2024

Celera Corporation
Company typeSubsidiary
Nasdaq: CRA
IndustryTechnology
Founded1998; 27 years ago (1998)
HeadquartersAlameda, California, United States
Key people
ProductsScientific & Technical Instruments
Number of employees
554[1]
ParentQuest Diagnostics
Websitewww.celera.com

Celera Corporation is a subsidiary of Quest Diagnostics which focuses on genetic sequencing and related technologies. It was founded in 1998 as a business unit of Applera, spun off into an independent company in 2008, and finally acquired by Quest Diagnostics in 2011.[2]

History

[edit]

Originally headquartered in Rockville, Maryland (relocated to Alameda, California), it was established in May 1998 by PE Corporation (later renamed to Applera), with Dr. J. Craig Venter from The Institute for Genomic Research (TIGR) as its first president. While at TIGR, Venter and Hamilton Smith led the first successful effort to sequence an entire organism's genome, that of the Haemophilus influenzae bacterium. Celera was formed for the purpose of generating and commercializing genomic information. Its stock is a tracking stock of Applera, along with the tracking stock of Applera's larger Applied Biosystems Group business unit.

Celera sequenced the human genome at a fraction of the cost of the publicly funded Human Genome Project (HGP), using about $300 million of private funding versus approximately $3 billion of taxpayer dollars.[citation needed] However, a significant portion of the human genome had already been sequenced when Celera entered the field, and thus Celera did not incur any costs with obtaining the existing data, which was freely available to the public from GenBank. Celera's approach, which used shotgun sequencing, spurred the public HGP to accelerate its effort and shift its projected timetable from 2005 to 2003.[citation needed]

Critics of initial efforts by Celera Genomics to hold back data from sections of genome they sequenced for commercial exploitation felt that it would retard progress in science as a whole. These critics pointed to the open access policy for gene sequences from the publicly funded Human Genome Project.[3] Later, the company changed their policy and made their sequences available for non-commercial use but set a maximum threshold for amount of sequence data that a researcher could download at any given time.[citation needed]

The rise and fall of Celera as an ambitious competitor of the Human Genome Project is the main subject of the book The Genome War by James Shreeve, who followed Venter around for two years in the process of writing the book. A view from the public effort's side is that of Nobel laureate Sir John Sulston in his book The Common Thread: A Story of Science, Politics, Ethics and the Human Genome. Anthropologist Paul Rabinow also based his 2005 book A Machine to Make a Future on Celera.

Genomes sequenced by Celera Genomics

[edit]

Eukaryotes:

References

[edit]
  1. ^ "Company Profile for Celera Group (CRA)". Archived from the original on 2011-11-16. Retrieved 2008-10-22.
  2. ^ https://www.celera.com/celera/pr_1305673632 Archived 2011-07-09 at the Wayback Machine Quest Diagnostics Successfully Completes Acquisition of Celera, May 17, 2011.
  3. ^ Yamey, G. (17 February 2001). "Dispute as rival groups publish details of human genome". BMJ. 322 (7283): 381. doi:10.1136/bmj.322.7283.381. PMC 1119622. Gale A71350527 ProQuest 1777608398.
  4. ^ Venter, J. Craig; Adams, Mark D.; Myers, Eugene W.; et al. (16 February 2001). "The Sequence of the Human Genome". Science. 291 (5507): 1304–1351. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
  5. ^ Singer, Emily (2007-09-04). "Craig Venter's Genome". MIT Technology Review. Five years ago, Craig Venter let out a big secret. As president of Celera Genomics, Venter had led the race between his company and a government-funded project to decode the human genome. After leaving Celera in 2002, Venter announced that much of the genome that had been sequenced there was his own.
  6. ^ Newspaperarticle from "Handelsblatt", 2000-10-12

Further reading

[edit]
[edit]