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== Presence in semen, and as proof in rape cases ==
==Corn syrup entry in carbohydrate content table==
I noticed the corn syrup entry in the table "Carbohydrate content of commercial sweeteners" doesn't have percentages that add up to 100. I couldn't find the real numbers, but I'm pretty confident that's a mistake. [[Special:Contributions/142.150.224.138|142.150.224.138]] ([[User talk:142.150.224.138|talk]]) 20:20, 16 November 2017 (UTC)


Semen is the only human product that contains any appreciable amount of fructose. For this reason it is a "marker" in rape cases. The logical place in Wikipedia for this information is in this article.[[Special:Contributions/38.104.70.30|38.104.70.30]] ([[User talk:38.104.70.30|talk]]) 22:47, 24 February 2023 (UTC)captcrisis
==Fructose is a Hexose==
Perhaps mention that fructose is considered a hexose sugar? [[Special:Contributions/108.2.177.109|108.2.177.109]] ([[User talk:108.2.177.109|talk]]) 05:39, 13 February 2011 (UTC)


== Talk topic on contradictory information from EFSA's perspective? ==
==Mention how fructose is synthesised?==
Photosynthesis results in glucose and oxygen, but how do plants make fructose? [[Special:Contributions/207.191.183.218|207.191.183.218]] ([[User talk:207.191.183.218|talk]]) 22:17, 11 March 2011 (UTC)


In Potential health effects section, there is a Self-contradictory template that states:
==Metabolic priority in regards to liver disease==
:[[Fructose#Liver disease]]: ''"When fructose reaches the liver," says Dr. William J. Whelan, a biochemist at the University of Miami School of Medicine, "the liver goes bananas and stops everything else to metabolize the fructose."''
I have heard similar things said of alcohol. Is there any evidence that EVERYTHING is stopped to metabolize fructose? If there were free fructose and free alcohol, which would the liver prioritize, or perhaps it is able to do multiple jobs simultaneously? [[User:Dictabeard|DB]] ([[User talk:Dictabeard|talk]]) 19:05, 12 April 2011 (UTC)


{{Blockquote
== Definition of "high/excess fructose consumption/intake/diet" ==
|{{Self-contradictory|about=the EFSA's perspective, in summary, regarding fructose, please compare to the lead|1=section|date=March 2023}}

}}
These phrases occur many times in the article but no actual indication is given of exactly what is meant. (I.e. exactly how much is "too much"?)<br />
Does anyone know?<br />
Thanks<br />--<small>[[User:TyrS|'''<span style="color:#702963;background:#967BB6">&nbsp;TyrS&nbsp;</span>''']][[User talk:TyrS#top|'''<span style="color:#967BB6;background:#702963">&nbsp;chatties&nbsp;</span>''']]</small> 06:38, 15 April 2011 (UTC)

== Composition of Corn Syrup ===
In the table ''Carbohydrate content of commercial sweeteners (percent)'' the numbers in the corn syrup row don't add to 100%. What is the remaining 65% carbohydrate content? It would be great if somebody more informed than myself could verify whether this discrepancy is intentional.[[Special:Contributions/108.67.71.45|108.67.71.45]] ([[User talk:108.67.71.45|talk]]) 06:07, 20 April 2011 (UTC)

I'm also convinced this is an error. Corn syrup's carbohydrate content should be glucose and perhaps maltose. See: http://www.ochef.com/362.htm but it needs a more official source. <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/134.121.109.99|134.121.109.99]] ([[User talk:134.121.109.99|talk]]) 20:35, 10 August 2011 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->

== Unsupported claim / non-sequitur ==

The article states:

:Although all simple sugars have nearly identical chemical formulae, each has distinct chemical properties. This can be illustrated with pure fructose. A journal article reports that, "...fructose given alone increased the blood glucose almost as much as a similar amount of glucose (78% of the glucose-alone area)".

These statements have no apparent relation to one another. A more obvious example of distinct chemical properties would be differing solubility in water, not a random biological pheonomenon. Certainly biology is at its roots chemistry, but many steps removed and with various selective agents driving reaction preferences. Without additional context the example given does not illustrate the point at hand. --[[User:Belg4mit|Belg4mit]] ([[User talk:Belg4mit|talk]]) 14:36, 11 July 2011 (UTC)
:Agreed, but I don't know how to fix that without deleting those 2 sentences. [[User:Dr. Morbius|Dr. Morbius]] ([[User talk:Dr. Morbius|talk]]) 20:04, 12 July 2011 (UTC)


Learning about sugars, I decided to look here to see what comments were posted. It is awkward. Stumbling upon this, I recommend either removing the second sentence completely, or separating the two sentences (into their appropriate paragraphs, but I have no suggestion where), or if you don't want to remove the second (less desirable because the second still does not support the first) you may consider something like this:

:While all simple sugars have nearly identical chemical formulae, for the most part, each has quite distinct chemical properties. One [notable?] exception is illustrated with pure fructose: a journal article reports that, "...fructose given alone increased the blood glucose almost as much as a similar amount of glucose (78% of the glucose-alone area)".

However, I think I have read in other places (wiki) that say (or seem to say) that Fructose has an effect that differs from Sucrose - the combination of the Fructose and Glucose in the Sucrose being theorized as the contributing factor to the difference. The presence of the Glucose somehow moderating the Fructose's (different) effect. (not my field, so it's getting complicated for me)

However, the 'journal article' should be cited if the second sentence remains.
Hope this helps & Regards [[User:EngineerSteve| -- Steve -- ]] ([[User talk:EngineerSteve|talk]]) 17:11, 11 December 2011 (UTC)

I just want to also say that this paragraph is troubling. In fact it contradicts a paragraph a bit later that says GI of fructose is 19 vs. 100 for glucose. GI = glycemic index = effect on blood glucose. How can it be 78% and 19%? It also contradicts info on metabolism of fructose which happens mostly in the liver whereas glucose just passes into the bloodstream. From my reading I think the 78% is not trustworthy. I have seen more references to fructose not having a significant impact on blood glucose and insulin. It could be just that the 78% study was with diabetic patients only. At any rate, it needs to be called out somehow. Sorry I'm not expert enough to have a better suggestion... [[Special:Contributions/74.3.100.30|74.3.100.30]] ([[User talk:74.3.100.30|talk]]) 00:28, 6 November 2012 (UTC) JPL

==Fructolysis==

I corrected some errors in the fructolysis section (previously claimed that initial metabolism produces fructose-1,6-biphosphate) and added a link to the [[fructolysis]] page. I think large sections here are redundant with the fructolysis page and could be scrapped. Also, the further metabolic processes discussed (glycogen and triglyceride synthesis) are not intimately related to fructose, and are described on separate pages, and should probably be removed. [[User:Rollowicz|Rollowicz]] ([[User talk:Rollowicz|talk]]) 09:29, 30 July 2011 (UTC)

== Out of topic info in intro ==

This seems out of place to me: "Sucrose is a disaccharide with a molecule of glucose and a molecule of fructose bonded together with a glycosidic linkage. Most modern fruits and vegetables have been bred to have much higher sugar content than the wild plants they are descended from." <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/18.189.112.118|18.189.112.118]] ([[User talk:18.189.112.118|talk]]) 02:45, 19 October 2011 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->

I agree, and I deleted both sentances. [[User:Kduckworth|Kduckworth]] ([[User talk:Kduckworth|talk]]) 05:56, 5 February 2012 (UTC)kate

==Figure 1 is incorrect==
The beta D fructose in Figure 1 is incorrect.
See http://sv.wikipedia.org/wiki/Fruktos for the correct image. <small><span class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Htreadup|Htreadup]] ([[User talk:Htreadup|talk]] • [[Special:Contributions/Htreadup|contribs]]) 12:57, 27 October 2011 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->
:The image used as Figure 1 ([[:File:Fructose-isomers.jpg]]) does not have anything labeled "beta D fructose". Can you be more specific about which image is your concern? -- [[User:Edgar181|Ed]] ([[User talk:Edgar181|Edgar181]]) 13:04, 27 October 2011 (UTC)

:Agreed, the figure is actually of Tagatose, not Fructose, and needs to be removed or replaced with the correct figure. [[User:AJRobbins|AJRobbins]] ([[User talk:AJRobbins|talk]]) 17:13, 29 April 2015 (UTC)

== Increased fructose associates with elevated blood pressure. -- {{PMID|20595676}} ==

Jalal DI, Smits G, Johnson RJ, Chonchol M.

Increased fructose associates with elevated blood pressure.

J Am Soc Nephrol. 2010 Sep;21(9):1543-9. Epub 2010 Jul 1.

{{PMID|20595676}}
{{PMC|3013529}}

Free PMC Article

http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=20595676

http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20595676/?tool=pubmed


Abstract

The recent increase in fructose consumption in industrialized nations mirrors the rise in the prevalence of hypertension, but epidemiologic studies have inconsistently linked these observations. We investigated whether increased fructose intake from added sugars associates with an increased risk for higher BP levels in US adults without a history of hypertension. We conducted a cross-sectional analysis using the data collected from the National Health and Nutrition Examination Survey (NHANES 2003 to 2006) involving 4528 adults without a history of hypertension. Median fructose intake was 74 g/d, corresponding to 2.5 sugary soft drinks each day. After adjustment for demographics; comorbidities; physical activity; total kilocalorie intake; and dietary confounders such as total carbohydrate, alcohol, salt, and vitamin C intake, an increased fructose intake of > or =74 g/d independently and significantly associated with higher odds of elevated BP levels: It led to a 26, 30, and 77% higher risk for BP cutoffs of > or =135/85, > or =140/90, and > or =160/100 mmHg, respectively. These results suggest that high fructose intake, in the form of added sugar, independently associates with higher BP levels among US adults without a history of hypertension.
Comment in


{{PMID|20595676}}
{{PMC|3013529}}

Free PMC Article

http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=20595676

http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20595676/?tool=pubmed

[[Special:Contributions/99.190.133.143|99.190.133.143]] ([[User talk:99.190.133.143|talk]]) 23:05, 1 November 2011 (UTC)

== Increased fructose associates with elevated blood pressure. -- {{PMID|20595676}} ==

Jalal DI, Smits G, Johnson RJ, Chonchol M.

Increased fructose associates with elevated blood pressure.

J Am Soc Nephrol. 2010 Sep;21(9):1543-9. Epub 2010 Jul 1.

{{PMID|20595676}}
{{PMC|3013529}}

Free PMC Article

http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=20595676

http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20595676/?tool=pubmed


Abstract

The recent increase in fructose consumption in industrialized nations mirrors the rise in the prevalence of hypertension, but epidemiologic studies have inconsistently linked these observations. We investigated whether increased fructose intake from added sugars associates with an increased risk for higher BP levels in US adults without a history of hypertension. We conducted a cross-sectional analysis using the data collected from the National Health and Nutrition Examination Survey (NHANES 2003 to 2006) involving 4528 adults without a history of hypertension. Median fructose intake was 74 g/d, corresponding to 2.5 sugary soft drinks each day. After adjustment for demographics; comorbidities; physical activity; total kilocalorie intake; and dietary confounders such as total carbohydrate, alcohol, salt, and vitamin C intake, an increased fructose intake of > or =74 g/d independently and significantly associated with higher odds of elevated BP levels: It led to a 26, 30, and 77% higher risk for BP cutoffs of > or =135/85, > or =140/90, and > or =160/100 mmHg, respectively. These results suggest that high fructose intake, in the form of added sugar, independently associates with higher BP levels among US adults without a history of hypertension.
Comment in


{{PMID|20595676}}
{{PMC|3013529}}

Free PMC Article

http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=20595676

http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20595676/?tool=pubmed <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/99.190.133.143|99.190.133.143]] ([[User talk:99.190.133.143|talk]]) 23:12, 1 November 2011 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->

== Gout citation ==

"Gout" section: Today I added a citation for the non-cited mention of a "recent" British Medical Journal article linking fructose consumption with incidence of gout. By searching online, I found a 2008 BMJ study that fits nicely with the assertion made; then re-wrote the sentence to express more precisely the conclusion of this study, but I cannot say for certain whether I located the same study that the author of that sentence had in mind. [[User:Reverence Still|Reverence Still]] ([[User talk:Reverence Still|talk]]) 00:25, 5 December 2011 (UTC)

== Health Effects Re Diabetics ==

The descriptions of effects of fructose upon diabetics, addressed briefly within a few different sub-sections of the "Health Effects" section, seem to have been written by multiple people of differing views. Which of course they were. Would a knowledgeable person please helpfully review and re-write these sub-sections to be more clear and consistent on the topic of fructose's effect on diabetics? [[User:Reverence Still|Reverence Still]] ([[User talk:Reverence Still|talk]]) 00:43, 5 December 2011 (UTC)

== Potential Health Effects ==
=== Compared to sucrose ===

The claim that sucrose and high fructose corn syrup have similar physiological effects seems to be overstating the conclusion cited in the subsequent sentences. Melanson et. al found that HFCS and sucrose are similar in the short term but "Longer-term studies on connections between HFCS, potential mechanisms, and body weight have not been conducted". Hence, the statement in this section must have a smaller scope (i.e. the short term physiological effects of HFCS and sucrose appear to be similar. However, long term studies have yet to be conducted). <small><span class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Austin.momii|Austin.momii]] ([[User talk:Austin.momii|talk]] • [[Special:Contributions/Austin.momii|contribs]]) 01:50, 10 January 2012 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->

== Dispute over claims made in a reference ==

If a claim is made in the article and it's backed up by a reference and you don't like the claim then you need to find another reference that disputes the original reference. If you disagree with the reference you need to find something that contradicts it. Your opinion would not be a valid claim to contradict the reference. If you have a dispute with the authors of a study WP is not the place to hash out your disagreement. The claims made in the following paragraph are backed up by the reference:

*Fructose is a [[reducing sugar]], as are all monosaccharides. The spontaneous chemical reaction of simple sugar molecules binding to proteins, known as [[glycation]], is thought to be a significant cause of damage in diabetics. Fructose appears to be equivalent to glucose in this regard and so does not seem to be a better answer for diabetes for this reason alone, save for the smaller quantities required to achieve equivalent sweetness in some foods.<ref>{{Cite journal|last=McPherson|first=JD|coauthors=Shilton BH, Walton DJ|url=|title=Role of fructose in glycation and cross-linking of proteins. PMID 132203|journal=Biochemistry|volume=27|issue=5|pages=1901–7|month=November|year=1988|doi=10.1021/bi00406a016|pmid=3132203}}</ref>

Adding things to the claim that are not in the reference simply because you don't agree with the results of the study used in the reference is inappropriate. Find a study that contradicts what's in the paragraph but don't edit the paragraph by adding irrelevant claims. The reference that is used makes no mention of rats being used as test subjects therefore adding the claim that the effects described in the article were observed in rats is irrelevant. If you have another study that makes the same claim using a rat model then add it to the article but don't change the original claim in the paragraph. [[User:Dr. Morbius|Dr. Morbius]] ([[User talk:Dr. Morbius|talk]]) 19:55, 28 March 2012 (UTC)

: Title of the Levi and Werman study already used in the paragraph before my edits is: Long-Term Fructose Consumption Accelerates Glycation and Several Age-Related Variables '''in Male Rats'''.[http://jn.nutrition.org/content/128/9/1442.long] Quoting from the paper, Discussion paragraph 4: ''This study demonstrates that long-term fructose feeding accelerates aging as expressed by changes in various age-related markers measured in collagen from skin and bones.''

: Making interpretation about any fructose effect on human metabolism or skin/bone health is simply conjecture, so must be stated as such for the common lay reader of this article. The tone of this paragraph is that fructose consumption is linked to diabetes, which, by scientific evaluation, is preposterous and only preliminarily tested.

: The McPherson article was correctly cited as evidence for the potential -- but not proven -- effect on proteins, as that study was only an in vitro analysis of such effects, so is also preliminary and unsubstantiated for any interpretation about diabetes.

: I suggest you re-read the paragraph and its references, and, if still confused, submit the issue for dispute resolution.--[[User:Zefr|Zefr]] ([[User talk:Zefr|talk]]) 23:38, 28 March 2012 (UTC)
::The original edits that you did did not use that reference. The original claim that was there that used the Werman reference was about senescence not about glycation. You then edited the claim that was about glycation and misrepresented that it was about rats while using the Mcpherson reference. [[User:Dr. Morbius|Dr. Morbius]] ([[User talk:Dr. Morbius|talk]]) 19:01, 29 March 2012 (UTC)
{{reflist talk}}

== Fructans ==

Under Food Sources it states.... "Fructose exists in foods either as a free monosaccharide or bound to glucose as sucrose, a disaccharide"

What about when it exists as a fructan? According to Wikipedia a Fructan is is "a polymer of fructose molecules".

"Fructans with a short chain length are known as fructooligosaccharides, whereas longer chain fructans are termed inulins. Fructans occur in foods such as agave, artichokes, asparagus, leeks, garlic, onions (including spring onions), yacon, jícama, and wheat.

http://en.wikipedia.org/wiki/Fructan
http://en.wikipedia.org/wiki/Fructooligosaccharide

[[User:CompassKT|CompassKT]] ([[User talk:CompassKT|talk]]) 18:48, 26 October 2012 (UTC)

== Oranges ==
I'd be interested in seeing oranges or orange juice in the list. In fact, I think a juices list would be very useful. -Reticuli [[Special:Contributions/65.29.194.159|65.29.194.159]] ([[User talk:65.29.194.159|talk]]) 17:18, 31 March 2013 (UTC)

== The UC Davis study ==
Interesting. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673878/ -Reticuli [[Special:Contributions/65.29.194.159|65.29.194.159]] ([[User talk:65.29.194.159|talk]]) 17:41, 31 March 2013 (UTC)

== "may promote overeating" ==

This is incorrect reasoning. If fructose does not stimulate satiety, the only thing that can be said is that it does not discourage overeating. There is no logic in the statement "fructose may not influence metabolic activity or blood flow in brain regions regulating satiety" that can lead to the conclusion that it "may promote overeating." A correctly-reasoned statement would be "may not discourage overeating." Put another way, there is nothing in the precedent statement that indicates that fructose may cause someone to eat more. It just may not cause them to eat less. [[Special:Contributions/99.6.194.122|99.6.194.122]] ([[User talk:99.6.194.122|talk]]) 22:29, 19 May 2013 (UTC)

The two statements are logically equivalent. You're just introducing a double negative.[[Special:Contributions/108.131.127.169|108.131.127.169]] ([[User talk:108.131.127.169|talk]]) 16:25, 19 October 2015 (UTC)

Actually, they're not logically equivalent. It is true that "causes to eat more" entails "does not cause to eat less", but the converse is not true, since something might have neither effect, that is, might neither cause to eat more nor cause to eat less (and many things probably fall into that category, in fact). <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/75.39.189.221|75.39.189.221]] ([[User talk:75.39.189.221#top|talk]]) 01:09, 21 April 2017 (UTC)</small> <!--Autosigned by SineBot-->

== Please add ball and stick diagram ==

It would be immensely helpful for me (and I'm sure other users) if someone could upload a ball and stick diagram in the infobox to the right. See Glucose or Aspartame as examples.

Thank you. <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/66.201.44.132|66.201.44.132]] ([[User talk:66.201.44.132|talk]]) 00:07, 16 August 2013 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->

: Done. I did it a few months ago, but thought I'd reply for completion. [[User:That kiwi guy|That kiwi guy]] ([[User talk:That kiwi guy|talk]]) 09:53, 13 June 2014 (UTC)

== table may be incorrect ==

The table "Carbohydrate content of commercial sweeteners" seems to be inconsistent. In some cases (e.g., granulated sugar) the sucrose column clearly includes the values from the fructose and glucose columns, and in other cases (e.g., HFCS) it clearly doesn't. This should be corrected, and it might also help clarify things to label the first two columns to clarify whether they're free vs. total fructose and glucose. [[User:Inhumandecency|Inhumandecency]] ([[User talk:Inhumandecency|talk]]) 18:30, 23 November 2013 (UTC)

== Clarification of fructose absorption with/without presence of glucose ==

The article currently states: "When fructose is ingested as part of the disaccharide sucrose, absorption capacity is much higher because fructose exists in a 1:1 ratio with glucose. It appears that the GLUT5 transfer rate may be saturated at low levels, and absorption is increased through joint absorption with glucose." If the absorption were increased due to the 1:1 fructose to glucose ratio, then it would seem that fructose absorption would also increase if it were ingested in the form of high fructose corn syrup (HFCS) assuming it were a variety with 50% of each fructose and glucose. If the conclusion of the last sentence is true, then the section should be reworded so that it does not single out sucrose, i.e. it should state that both sucrose and HFCS increase fructose absorption. If this is not true, then the explanation "absorption capacity is much higher because fructose exists in a 1:1 ratio with glucose" should be changed. I do not have the background to confidently make the change. [[Special:Contributions/66.91.252.195|66.91.252.195]] ([[User talk:66.91.252.195|talk]]) 03:19, 26 April 2014 (UTC)

== External links modified ==

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== External links modified ==

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== Pronunciation ==

How is '''fructose''' pronounced? I've heard it mostly as /fr<u>oo</u>k'tose/, although I've also heard it occasionally as /fr<u>u</u>k'tose/. It would be nice to add the IPA pronunciation to the lede sentence. —&nbsp;[[User:Loadmaster|Loadmaster]] ([[User talk:Loadmaster|talk]]) 21:48, 10 February 2017 (UTC)

== Fructose metabolism without oxygen ==

http://www.npr.org/sections/thetwo-way/2017/04/20/524511231/researchers-find-yet-another-reason-why-naked-mole-rats-are-just-weird
What is the pathway, it must be similar to the [[Cori cycle]] which can generate energy from glucose by converting it to lactic acid without oxygen. --[[User:Richard Arthur Norton (1958- )|Richard Arthur Norton (1958- )]] ([[User talk:Richard Arthur Norton (1958- )|talk]]) 19:20, 20 April 2017 (UTC)

== Food sources ==

Below Table 1 it reads: "The fructose/glucose ratio is calculated by dividing the sum of free fructose plus half sucrose by the sum of free glucose plus half sucrose."<br>

So the ratio is always 1?<br>

[[Special:Contributions/213.127.56.207|213.127.56.207]] ([[User talk:213.127.56.207|talk]]) 14:54, 18 May 2018 (UTC)

== Citation roughly contradicts the claim it was cited as support for. ==

This article stated that fructose "may" cause cardiovascular disease and diabetes, citing a journal article (Rippe, James M.; Angelopoulos, Theodore J. (2015-07-01). "Fructose-containing sugars and cardiovascular disease" (CVD). Advances in Nutrition (Bethesda, Md.). 6 (4): 430–439). In fact, that article found "levels within the normal range of human consumption are not uniquely related to CVD risk factors," noting only that triglycerides, which are linked to cardio-vascular disease and diabetes, "may rise ... when simple sugars exceed 20% of energy per day, particularly in hypercaloric settings." As cited, this Wikipedia article would imply that the source contributes to concerns of a possible link between normal consumption of fructose and diseases such as diabetes and CVD, when the opposite is true. <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/205.175.220.10|205.175.220.10]] ([[User talk:205.175.220.10#top|talk]]) 15:09, 31 May 2019 (UTC)</small> <!--Autosigned by SineBot-->

== Mischaracterization of the "European Food Safety Authority" paper ==


I'm guessing [[Talk:Fructose/Archive 2#Mischaracterization of the %22European Food Safety Authority%22 paper|this is the mentioned talk post]], which was [https://en.wikipedia.org/enwiki/w/index.php?title=Talk:Fructose&diff=prev&oldid=1141423162 archived back in Feb 2023], before the Mar 2023 mentioned in the template.
The article says "An expert panel of the European Food Safety Authority concluded that fructose is preferred in food and beverage manufacturing to replace sucrose and glucose due to the lower effect of fructose on blood glucose levels following a meal."<ref name=MalikHu2015>{{cite journal|last1=Malik|first1=Vasanti S.|last2=Hu|first2=Frank B.|title=Fructose and Cardiometabolic Health: What the Evidence from Sugar-Sweetened Beverages Tells Us|journal=Journal of the American College of Cardiology|volume=66|issue=14|year=2015|pages=1615–1624|issn=0735-1097|doi=10.1016/j.jacc.2015.08.025|pmid=26429086|pmc=4592517}}</ref> However, that's not at all what the paper from EFSA says. This wording isn't supported by the EFSA paper, which is much more narrow.


Should a new topic be started, or the existing one unarchived, or the template removed? As a casual user, I found it a bit confusing to figure out where to get more details, with there just being the one topic above that was left unarchived. But also not familiar enough with WP editing to know if it's normal to reference archived talk posts in the article. [[User:Pb7280|Pb7280]] ([[User talk:Pb7280|talk]]) 23:10, 11 May 2023 (UTC)
The wording in the wikipedia entry suggests that fructose should be preferred in the preparation of foodstuffs because it lowers blood glucose levels after a meal. In contrast, EFSA paper is a narrow conclusion of a request to evaluate precise health claims about fructose. ESFA concludes that the precise wording "Consumption of fructose leads to a lower blood glucose rise than consumption of sucrose or glucose" is scientifically accurate, but does not then go on to recommend that foodstuffs be prepared with fructose instead of glucose or other sugars.


:The challenge from the March 2023 talk page about whether a controversy exists within the EFSA opinion was raised by an IP editor whose interpretation was incorrect. There is no controversy.
THE EFSA paper also very explicitly warns about the consequences of high fructose consumption: "The Panel notes that high intakes of fructose may lead to metabolic complications such as dyslipidaemia, insulin resistance and increased visceral adiposity.". The wording of the wikipedia article fails to mention such concerns and creates an impression that an expert government-level authority has blessed fructose as strictly better than other sugars, which is harmful to the general public as there is ample scientific evidence that fructose increases food consumption and body fat, through suppression of the satiety signal and other processes. See e.g. <ref name="CampbellSchlappal2014">{{cite journal|last1=Campbell|first1=Eric|last2=Schlappal|first2=Anna|last3=Geller|first3=Eliana|last4=Castonguay|first4=Thomas W.|title=Fructose-Induced Hypertriglyceridemia: A Review|year=2014|pages=197–205|doi=10.1016/B978-0-12-407869-7.00019-2}}</ref> for a review.
:I removed the "contradicton box" with other minor edits, [https://en.wikipedia.org/enwiki/w/index.php?title=Fructose&diff=prev&oldid=1154362574 here.] [[User:Zefr|Zefr]] ([[User talk:Zefr|talk]]) 00:19, 12 May 2023 (UTC)
{{reflist-talk}}
::The [https://en.wikipedia.org/wiki/Fructose#Potential_health_effects section on Potential health effects] explains the issue adequately: in isocaloric amounts, fructose is ''not'' an independent factor for weight gain or disease [refs 10, 54], but its '''excessive''' consumption &ndash; as for any sweetener &ndash; adds calories and promotes weight gain, which can be a risk factor for the diseases mentioned [refs 54-58]. The EFSA panel ([https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2011.2223 article here]) concluded in the abstract: (quote) "The Panel considers that in order to bear the claim, glucose or sucrose should be replaced by fructose in sugar sweetened foods or beverages. The target population is individuals who wish to reduce their post-prandial glycaemic responses," leading to its main conclusion (end of article): "The following wording reflects the scientific evidence: "Consumption of fructose leads to a lower blood glucose rise than consumption of sucrose or glucose. In order to bear the claim, glucose or sucrose should be replaced by fructose in sugar-sweetened foods or beverages. The target population is individuals who wish to reduce their post-prandial glycaemic responses." --[[User:Zefr|Zefr]] ([[User talk:Zefr|talk]]) 18:01, 19 January 2020 (UTC)


== Relative sweetness: weight or mole basis? ==
::::Thank you for your reply! I think there might be a confusion about the role and purpose of the EFSA paper: it's not a recommendation about which sugars should be used in foodstuffs, but rather a decision about whether a specific marketing claim about food products is sufficiently grounded in science to allow food producers in the European Union to make it.


It is important to say whether sweetness is compared on a molar or weight basis. If the basis is weight as I suspect, the enhanced sweetness of fructose over glucose could be explained by the fact that its molecular weight is about half that of sucrose. Hydrolysis of sucrose would have a smaller effect on sweetness, as only half the weight of sucrose is converted to fructose with greater sweetness, while the other half is converted to glucose with lesser sweetness.[[User:Eaberry|Eaberry]] ([[User talk:Eaberry|talk]]) 15:47, 18 January 2024 (UTC)
::::In 2006, the [[European Parliament]] passed regulation 1924/2006 (https://eur-lex.europa.eu/legal-content/EN/TXT/HTML/?uri=CELEX:32006R1924&from=en) imposing limits on health claims that food manufacturers may advertise in their products. The process for determining which claims are allowed is described in Commission Regulation 432/2012 (https://eur-lex.europa.eu/legal-content/EN/TXT/HTML/?uri=CELEX:32012R0432&from=EN). It works as follows: the [[European Commission]] compiles a list of candidate claims, then it submits them to EFSA which provides an expert opinion on whether the claim is scientifically valid. If so, it is allowed. Within the framework of this process, EFSA was asked whether the claim that "Consumption of foods containing fructose leads to a lower blood glucose rise compared to foods containing sucrose or glucose" is backed by science, which led to the paper we are discussing. EFSA agreed that this claim is scientifically verified but that "In order to bear the claim, glucose and/or sucrose should be replaced by fructose in sugar-sweetened foods or drinks so that the reduction in content of glucose and/or sucrose, in these foods or drinks, is at least 30 %." -- see the ANNEX in regulation 536/2013 of the European Union https://eur-lex.europa.eu/legal-content/EN/TXT/HTML/?uri=CELEX:32013R0536&from=EN#d1e32-7-1, where this specific language is approved with said proviso.


:Did you mean 'sweetness of fructose over '''sucrose?''' That would be logical. However, the following reference says that fructose is twice as sweet on a molar basis:
::::In other words, the EFSA paper is not a recommendation for fructose to substitute other sweeteners, but rather a very narrow opinion about whether a marketing claim on food products is sufficiently based on our scientific understanding to allow food producers to make it in the European Union.
:by DT Cason · 1987 · Cited by 46 — Fructose is a very sweet sugar and on a molar basis is twice as sweet as sucrose ...
:I haven't read enough to have confidence in that answer so I haven't edited the article. [[User:SciberDoc|SciberDoc]] ([[User talk:SciberDoc|talk]]) 15:08, 27 February 2024 (UTC)


== Edit of table needed, please help if you have the skill required ==
::::In light of this, I suggest changing the wording in the Wikipedia article to something like "An expert panel from the EFSA deemed that 'consumption of foods …' is an allowable marketing claim for food products provided that in such products the content of other sugars is reduced by at least 30%"... though at that point I am not sure it is even worth mentioning this in the article.


Table 1. Sugar content of selected common plant foods (g/100g
::::My own opinion is that the claim itself, while scientifically valid, is misleading. Yes, fructose raises blood glucose less, but this obscures the many adverse health effects of fructose found in the scientific literature. I think that's why EFSA felt compelled to add an important caveat in their paper, that "The Panel notes that high intakes of fructose may lead to metabolic complications such as dyslipidaemia, insulin resistance and increased visceral adiposity.".
The headings 'Fruits', 'Vegetables' and 'Grains' need deleting. They are inappropriate and in the wrong places. As the table can usefully be sorted, any division into fruits vegetables and grains is bound to go wrong depending which way it is sorted (unless each section sorted separately which would make comparisons harder between items in different categories).


I attempted to delete the headings but everything I tried broke the table display when I tried it in the sandbox. Help from someone skilled with tables would be appreciated. Thanks.
:::: Whether or not fructose causes metabolic damage beyond its caloric value (e.g. whether "a calorie is a calorie" or not) is outside the scope of the current discussion point, so I will leave it there for now and possibly start a different (non-EFSA) topic on that.
[[User:SciberDoc|SciberDoc]] ([[User talk:SciberDoc|talk]]) 14:57, 27 February 2024 (UTC)


== Absolute sweetness of fructose is identical at 5 °C as 50 °C? ==
::::Thanks again for your diligence! <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/79.144.139.140|79.144.139.140]] ([[User talk:79.144.139.140#top|talk]]) 21:42, 19 January 2020 (UTC)</small> <!--Autosigned by SineBot-->
:::::We can let other editors evaluate, but my feeling is the article is factual, succinct, and well-documented on this issue as it is. You say there are "many adverse health effects of fructose found in the scientific literature," which I would dispute. There are many misunderstandings of fructose in the literature and public media, but expert positions - whether the FDA, EFSA, or the several [[WP:MEDREV]] reviews used in the article - correctly state that fructose (like any sweetener) is a problem only if over-consumed. --[[User:Zefr|Zefr]] ([[User talk:Zefr|talk]]) 00:58, 20 January 2020 (UTC)


I was not able to find this information in the cited source (Lee, Thomas D. (1 January 2000). "Sweeteners". Kirk-Othmer Encyclopedia of Chemical Technology. doi:10.1002/0471238961.19230505120505.a01.pub2. ISBN 978-0471238966.). Does anyone know where did this information come from? [[Special:Contributions/182.255.32.46|182.255.32.46]] ([[User talk:182.255.32.46|talk]]) 04:04, 30 August 2024 (UTC)
I would find that the paper is entirely misleading unless it can show that it was controlled against sucrose, given that sucrose is, by definition Fructose and Glucose chemically bonded together forming a disacharide sugar. Thus it inherently follows that proper methodology should show very little to no differences between Fructose and Sucrose. The reference material does not appear to have done this, and therefore would fail even the most nominal peer review standards for that reason alone, making it an unreliable scientific reference. [[Special:Contributions/98.178.179.240|98.178.179.240]] ([[User talk:98.178.179.240|talk]]) 19:17, 16 May 2020 (UTC)


:Ok I found it, but in the "sugars" section, not "sweeteners". In fact I suspect that most of the citations of this source should be "sugars". The sweeteners part barely talked about fructose at all. [[Special:Contributions/182.255.32.46|182.255.32.46]] ([[User talk:182.255.32.46|talk]]) 04:10, 30 August 2024 (UTC)
==References==
This article seems problematic in terms of it's references. Entire paragraphs and entire sections seem to rely on relatively few references. It is worth noting that each assertion the article makes should be supported by at least one reference, and that it should be clear as to what the reference citation is supposed to support, for ease of clarification of reading. [[Special:Contributions/98.178.179.240|98.178.179.240]] ([[User talk:98.178.179.240|talk]]) 19:08, 16 May 2020 (UTC)

Latest revision as of 04:10, 30 August 2024

Presence in semen, and as proof in rape cases

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Semen is the only human product that contains any appreciable amount of fructose. For this reason it is a "marker" in rape cases. The logical place in Wikipedia for this information is in this article.38.104.70.30 (talk) 22:47, 24 February 2023 (UTC)captcrisis[reply]

Talk topic on contradictory information from EFSA's perspective?

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In Potential health effects section, there is a Self-contradictory template that states:

I'm guessing this is the mentioned talk post, which was archived back in Feb 2023, before the Mar 2023 mentioned in the template.

Should a new topic be started, or the existing one unarchived, or the template removed? As a casual user, I found it a bit confusing to figure out where to get more details, with there just being the one topic above that was left unarchived. But also not familiar enough with WP editing to know if it's normal to reference archived talk posts in the article. Pb7280 (talk) 23:10, 11 May 2023 (UTC)[reply]

The challenge from the March 2023 talk page about whether a controversy exists within the EFSA opinion was raised by an IP editor whose interpretation was incorrect. There is no controversy.
I removed the "contradicton box" with other minor edits, here. Zefr (talk) 00:19, 12 May 2023 (UTC)[reply]

Relative sweetness: weight or mole basis?

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It is important to say whether sweetness is compared on a molar or weight basis. If the basis is weight as I suspect, the enhanced sweetness of fructose over glucose could be explained by the fact that its molecular weight is about half that of sucrose. Hydrolysis of sucrose would have a smaller effect on sweetness, as only half the weight of sucrose is converted to fructose with greater sweetness, while the other half is converted to glucose with lesser sweetness.Eaberry (talk) 15:47, 18 January 2024 (UTC)[reply]

Did you mean 'sweetness of fructose over sucrose? That would be logical. However, the following reference says that fructose is twice as sweet on a molar basis:
by DT Cason · 1987 · Cited by 46 — Fructose is a very sweet sugar and on a molar basis is twice as sweet as sucrose ...
I haven't read enough to have confidence in that answer so I haven't edited the article. SciberDoc (talk) 15:08, 27 February 2024 (UTC)[reply]

Edit of table needed, please help if you have the skill required

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Table 1. Sugar content of selected common plant foods (g/100g The headings 'Fruits', 'Vegetables' and 'Grains' need deleting. They are inappropriate and in the wrong places. As the table can usefully be sorted, any division into fruits vegetables and grains is bound to go wrong depending which way it is sorted (unless each section sorted separately which would make comparisons harder between items in different categories).

I attempted to delete the headings but everything I tried broke the table display when I tried it in the sandbox. Help from someone skilled with tables would be appreciated. Thanks. SciberDoc (talk) 14:57, 27 February 2024 (UTC)[reply]

Absolute sweetness of fructose is identical at 5 °C as 50 °C?

[edit]

I was not able to find this information in the cited source (Lee, Thomas D. (1 January 2000). "Sweeteners". Kirk-Othmer Encyclopedia of Chemical Technology. doi:10.1002/0471238961.19230505120505.a01.pub2. ISBN 978-0471238966.). Does anyone know where did this information come from? 182.255.32.46 (talk) 04:04, 30 August 2024 (UTC)[reply]

Ok I found it, but in the "sugars" section, not "sweeteners". In fact I suspect that most of the citations of this source should be "sugars". The sweeteners part barely talked about fructose at all. 182.255.32.46 (talk) 04:10, 30 August 2024 (UTC)[reply]