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{{Infobox officeholder
{{Infobox officeholder
| name = Chi-Huey Wong
| name = Chi-Huey Wong
| native_name = 翁啟惠
| native_name = {{nobold|翁啟惠}}
| image = Dr. Chi-Huey Wong.jpg
| image = Dr. Chi-Huey Wong.jpg
| office1 = [[Academia Sinica|President of the Academia Sinica]]
| caption = Wong in 2021
| office1 = 8th [[Academia Sinica|President of the Academia Sinica]]
| term_start1 = 19 October 2006
| term_start1 = 19 October 2006
| term_end1 = 10 May 2016
| term_end1 = 10 May 2016
| deputy1 = [[Chen Chien-jen]], Wang Fan-sen, etc.
| appointer1 =
| vicepresident1 = [[Andrew H. J. Wang]]<br>[[Chen Chien-jen]]<br>[[:zh:王瑜 (科學家)|Wang Yu]]<br>[[Wang Fan-sen]]
| predecessor1 = [[Yuan T. Lee]]
| successor1 = Wang Fan-sen {{small|(acting)}}
| predecessor1 = [[Yuan T. Lee]]
| birth_date = {{birth date and age|1948|8|3}}
| successor1 = [[Wang Fan-sen]] {{small|(acting)}}
| birth_place = [[Yizhu, Chiayi|Yizhu]], [[Tainan County]], Taiwan (now [[Chiayi County]])
| birth_date = {{birth date and age|1948|8|3}}
| birth_place = [[Yizhu, Chiayi|Yizhu]], [[Tainan County]], Taiwan (now [[Chiayi County]])
⚫
| education = [[National Taiwan University]] ([[B. S.|BS]], [[M. S.|MS]])<br />[[Massachusetts Institute of Technology]] ([[PhD]])
| party = [[Independent politician|Independent]]
| nationality = [[Taiwanese people|Taiwanese]]<br />[[United States|American]]
{{Infobox scientist
| embed = yes
| field = [[Biochemistry]]<br />[[Chemical biology]]
| work_institutions = {{ubl
|[[Texas A&M University]]
|[[The Scripps Research Institute]]
|[[Academia Sinica]] (Taiwan)
⚫
|[[National Taiwan University]]
}}
}}
⚫
| alma_mater = [[National Taiwan University]]<br />[[Massachusetts Institute of Technology]]
| doctoral_students = [[Carlos F. Barbas III]]
| prizes = [[F. Albert Cotton|F. A. Cotton]] Medal {{small|(2008)}}<br>[[Arthur C. Cope Award]] {{small|(2012)}}<br>[[Wolf Prize in Chemistry]] {{small|(2014)}}<br>[[Royal Society of Chemistry|Robert Robinson Award]] {{small|(2015)}}<br>[[Welch Award in Chemistry]] {{small|(2021)}}
}}}}


'''Chi-Huey Wong''' ({{zh|t=翁啟惠}}; born 3 August 1948) is a [[Taiwanese-American]] biochemist. He is currently the Scripps Family Chair Professor at the [[Scripps Research Institute]],<ref>{{Cite web|url=https://www.scripps.edu/faculty/wong/|title=Chi-Huey Wong {{!}} Scripps Research|website=www.scripps.edu|access-date=2019-10-14}}</ref> California in the department of chemistry. He is a member of the United States [[National Academy of Sciences]], as awarded the 2014 [[Wolf Prize in Chemistry]] and 2015 RSC Robert Robinson Award.<ref>{{Cite web|url=https://www.rsc.org/ScienceAndTechnology/Awards/RobertRobinsonAward/2015-Winner.asp|title=RSC Robert Robinson Award 2015 Winner|website=www.rsc.org|access-date=2019-10-14}}</ref> Wong is also the holder of more than 100 patents and publisher of more 700 scholarly academic research papers under his name.<ref>{{Cite web|url=https://scholar.google.com.tw/citations?user=GQLirSoAAAAJ|title=Chi-Huey Wong – Google Scholar Citations|website=scholar.google.com.tw|access-date=2019-10-14}}</ref>
'''Chi-Huey Wong''' ({{zh|t=翁啟惠}}; born 3 August 1948) is a [[Taiwanese-American]] biochemist. He is currently the Scripps Family Chair Professor at the [[Scripps Research Institute]].<ref>{{Cite web|url=https://www.scripps.edu/faculty/wong/|title=Chi-Huey Wong {{!}} Scripps Research|website=www.scripps.edu|access-date=2019-10-14}}</ref> He is a member of the United States [[National Academy of Sciences]], as awarded the 2014 [[Wolf Prize in Chemistry]] and 2015 RSC Robert Robinson Award.<ref>{{Cite web|url=https://www.rsc.org/ScienceAndTechnology/Awards/RobertRobinsonAward/2015-Winner.asp|title=RSC Robert Robinson Award 2015 Winner|website=www.rsc.org|access-date=2019-10-14}}</ref> Wong is also the holder of more than 100 patents and publisher of 700 more scholarly academic research papers under his name.<ref>{{Cite web|url=https://scholar.google.com.tw/citations?user=GQLirSoAAAAJ|title=Chi-Huey Wong – Google Scholar Citations|website=scholar.google.com.tw|access-date=2019-10-14}}</ref>


==Education==
==Education==
Wong  received his BS and MS in Biochemical Sciences from [[National Taiwan University]] in Taipei, followed by his PhD in chemistry in 1982 at the [[Massachusetts Institute of Technology]] under the direction of Professor [[George M. Whitesides]] to study the use of enzymes as catalysts in [[organic synthesis]].<ref>{{Cite web|url=http://www.genomics.sinica.edu.tw/chihueywong/CHWong.html|title=Dr. Chi-Huey Wong's Personal Webpage|website=www.genomics.sinica.edu.tw|access-date=2019-10-14|archive-date=2016-04-04|archive-url=https://web.archive.org/web/20160404043059/http://www.genomics.sinica.edu.tw/chihueywong/CHWong.html|url-status=dead}}</ref>
Wong earned his [[Bachelor of Science]] (B.S.) and [[Master of Science]] (M.S.) in biochemical sciences from [[National Taiwan University]] in Taipei. He then received a Ph.D. in chemistry in 1982 from the [[Massachusetts Institute of Technology]] (MIT) under the direction of [[George M. Whitesides]]. At MIT, he studied the use of enzymes as catalysts in [[organic synthesis]].<ref>{{Cite web|url=http://www.genomics.sinica.edu.tw/chihueywong/CHWong.html|title=Dr. Chi-Huey Wong's Personal Webpage|website=www.genomics.sinica.edu.tw|access-date=2019-10-14|archive-date=2016-04-04|archive-url=https://web.archive.org/web/20160404043059/http://www.genomics.sinica.edu.tw/chihueywong/CHWong.html|url-status=dead}}</ref>


==Research and career==
==Research and career==
Wong continued his postdoctoral research work with [[George M. Whitesides]] at [[Harvard University]] from 1982 to 1983, then began his independent career at [[Texas A&M University]] in the chemistry department. During his tenure at [[Texas A&M University]], he went through the ranks including assistant professor, associate professor, and professor of chemistry.
Wong continued his postdoctoral research work with [[George M. Whitesides]] at [[Harvard University]] from 1982 to 1983, then began his independent career at [[Texas A&M University]] in the chemistry department. During his tenure at [[Texas A&M University]], he went through the ranks including assistant professor, associate professor, and professor of chemistry.


Wong was appointed as the [[The Hahn Company|Ernest W. Hahn]] Chair and professor of chemistry at the [[Scripps Research|Scripps Research Institute]] and while he was a faculty member at Scripps, he also served as head of the [[Frontiers Research Foundation|Frontier Research]] Program on Glycotechnology at [[Riken]] in Japan<ref>{{Cite web|url=https://www.riken.jp/en/news_pubs/news/2017/20170411_1/|title=Third RIKEN-Academia Sinica Joint Conference {{!}} RIKEN|website=www.riken.jp|access-date=2019-10-23}}</ref> and director of the Genomics Research Center at [[Academia Sinica]],<ref>{{Cite web|url=http://www.genomics.sinica.edu.tw/chihueywong/CHWong.html|title=Dr. Chi-Huey Wong's Personal Webpage|website=www.genomics.sinica.edu.tw|access-date=2019-10-23|archive-date=2016-04-04|archive-url=https://web.archive.org/web/20160404043059/http://www.genomics.sinica.edu.tw/chihueywong/CHWong.html|url-status=dead}}</ref> and was later appointed by the President of the Republic of China (Taiwan) as the President of Academia Sinica. Now, he is  serving at the Scripps Research Institute as Scripps Family Chair Professor of Chemistry.<ref>{{Cite web|url=https://www.chemistryviews.org/details/ezine/11086073/70th_Birthday_ChiHuey_Wong.html|title=70th Birthday: Chi‐Huey Wong :: ChemViews Magazine :: ChemistryViews|website=www.chemistryviews.org|date=3 August 2018 |language=en|access-date=2019-10-23}}</ref>
Wong was appointed as the [[The Hahn Company|Ernest W. Hahn]] Chair and professor of chemistry at the [[Scripps Research|Scripps Research Institute]] and while he was a faculty member at Scripps, he also served as head of the [[Frontiers Research Foundation|Frontier Research]] Program on Glycotechnology at [[Riken]] in Japan<ref>{{Cite web|url=https://www.riken.jp/en/news_pubs/news/2017/20170411_1/|title=Third RIKEN-Academia Sinica Joint Conference {{!}} RIKEN|website=www.riken.jp|access-date=2019-10-23}}</ref> and director of the Genomics Research Center at [[Academia Sinica]],<ref>{{Cite web|url=http://www.genomics.sinica.edu.tw/chihueywong/CHWong.html|title=Dr. Chi-Huey Wong's Personal Webpage|website=www.genomics.sinica.edu.tw|access-date=2019-10-23|archive-date=2016-04-04|archive-url=https://web.archive.org/web/20160404043059/http://www.genomics.sinica.edu.tw/chihueywong/CHWong.html|url-status=dead}}</ref> and was later appointed by the President of the Republic of China (Taiwan) as the President of Academia Sinica. Now, he is  serving at the Scripps Research Institute as Scripps Family Chair Professor of Chemistry.<ref>{{Cite web|url=https://www.chemistryviews.org/details/ezine/11086073/70th_Birthday_ChiHuey_Wong.html|title=70th Birthday: Chi-Huey Wong :: ChemViews Magazine :: ChemistryViews|website=www.chemistryviews.org|date=3 August 2018 |language=en|access-date=2019-10-23}}</ref>


Wong is best known for his original contributions to glycoscience, especially his development of [[Chemoenzymatic reaction|chemo-enzymatic]] methods for the practical synthesis of [[oligosaccharide]]s<ref>{{Cite journal|last=Wong|first=C.|date=1989-06-09|title=Enzymatic catalysts in organic synthesis|journal=Science|language=en|volume=244|issue=4909|pages=1145–1152|doi=10.1126/science.2658059|pmid=2658059|bibcode=1989Sci...244.1145W|issn=0036-8075}}</ref><ref>{{Cite journal|last1=Koeller|first1=Kathryn M.|last2=Wong|first2=Chi-Huey|title=Enzymes for chemical synthesis|journal=Nature|language=en|volume=409|issue=6817|pages=232–240|doi=10.1038/35051706|pmid=11196651|issn=0028-0836|year=2001|bibcode=2001Natur.409..232K|s2cid=4339585}}</ref><ref>{{Cite journal|last=Sears|first=P.|date=2001-03-23|title=Toward Automated Synthesis of Oligosaccharides and Glycoproteins|journal=Science|volume=291|issue=5512|pages=2344–2350|doi=10.1126/science.1058899|pmid=11269314|bibcode=2001Sci...291.2344S|s2cid=25853502}}</ref><ref>{{Cite journal|last1=Machajewski|first1=Timothy D.|last2=Wong|first2=Chi-Huey|date=2000|title=The Catalytic Asymmetric Aldol Reaction|journal=Angewandte Chemie International Edition|language=en|volume=39|issue=8|pages=1352–1375|doi=10.1002/(sici)1521-3773(20000417)39:8<1352::aid-anie1352>3.0.co;2-j|pmid=10777624|issn=1521-3773}}</ref><ref>{{Cite journal|last1=Ichikawa|first1=Yoshitaka|last2=Lin|first2=Ying Chih|last3=Dumas|first3=David P.|last4=Shen|first4=Gwo Jenn|last5=Garcia-Junceda|first5=Eduardo|last6=Williams|first6=Mark A.|last7=Bayer|first7=Robert|last8=Ketcham|first8=Catherine|last9=Walker|first9=Leslie E.|date=1992-11-01|title=Chemical-enzymic synthesis and conformational analysis of sialyl Lewis X and derivatives|journal=Journal of the American Chemical Society|volume=114|issue=24|pages=9283–9298|doi=10.1021/ja00050a007|issn=0002-7863}}</ref> and [[glycoprotein]]s<ref>{{Cite journal|last1=Koeller|first1=Kathryn M.|last2=Wong|first2=Chi-Huey|title=Enzymes for chemical synthesis|journal=Nature|language=en|volume=409|issue=6817|pages=232–240|doi=10.1038/35051706|pmid=11196651|issn=0028-0836|year=2001|bibcode=2001Natur.409..232K|s2cid=4339585}}</ref><ref>{{Cite journal |last1=Sears |first1=P. |last2=Wong |first2=Chi-Huey |date=2001-03-23 |title=Toward Automated Synthesis of Oligosaccharides and Glycoproteins |journal=Science |volume=291 |issue=5512 |pages=2344–2350 |bibcode=2001Sci...291.2344S |doi=10.1126/science.1058899 |pmid=11269314 |s2cid=25853502}}</ref><ref>{{Cite journal|last1=Witte|first1=Krista|last2=Sears|first2=Pamela|last3=Martin|first3=Richard|last4=Wong|first4=Chi-Huey|date=1997-03-01|title=Enzymatic Glycoprotein Synthesis: Preparation of Ribonuclease Glycoforms via Enzymatic Glycopeptide Condensation and Glycosylation|journal=Journal of the American Chemical Society|volume=119|issue=9|pages=2114–2118|doi=10.1021/ja961846z|issn=0002-7863}}</ref><ref>{{Cite journal|last1=Brik|first1=Ashraf|last2=Ficht|first2=Simon|last3=Yang|first3=Yu-Ying|last4=Wong|first4=Chi-Huey|date=2006-11-01|title=Sugar-Assisted Ligation of N-Linked Glycopeptides with Broad Sequence Tolerance at the Ligation Junction|journal=Journal of the American Chemical Society|volume=128|issue=46|pages=15026–15033|doi=10.1021/ja065601q|pmid=17105315|issn=0002-7863|url=http://ntur.lib.ntu.edu.tw/bitstream/246246/218234/-1/28.pdf }}</ref><ref>{{Cite journal|last1=Payne|first1=Richard J.|last2=Wong|first2=Chi-Huey|date=2010-01-07|title=Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins|journal=Chemical Communications|language=en|volume=46|issue=1|pages=21–43|doi=10.1039/B913845E|pmid=20024291|issn=1364-548X}}</ref> and the hierarchical and programmable one-pot synthesis method for the rapid preparation of a large number of oligosaccharides.<ref>{{Cite journal|last1=Galan|first1=M. Carmen|last2=Benito-Alifonso|first2=David|last3=Watt|first3=Gregory M.|date=2011-05-21|title=Carbohydrate chemistry in drug discovery|journal=Organic & Biomolecular Chemistry|language=en|volume=9|issue=10|pages=3598–3610|doi=10.1039/C0OB01017K|pmid=21409288|issn=1477-0539}}</ref> The original synthetic methods developed by Wong along with his work on the development of glycan microarrays<ref>{{Cite journal|last1=Fazio|first1=Fabio|last2=Bryan|first2=Marian C.|last3=Blixt|first3=Ola|last4=Paulson|first4=James C.|last5=Wong|first5=Chi-Huey|date=2002-12-01|title=Synthesis of Sugar Arrays in Microtiter Plate|journal=Journal of the American Chemical Society|volume=124|issue=48|pages=14397–14402|doi=10.1021/ja020887u|pmid=12452714|issn=0002-7863|url=https://figshare.com/articles/journal_contribution/3641553}}</ref><ref>{{Cite journal|last1=Blixt|first1=Ola|last2=Head|first2=Steve|last3=Mondala|first3=Tony|last4=Scanlan|first4=Christopher|last5=Huflejt|first5=Margaret E.|last6=Alvarez|first6=Richard|last7=Bryan|first7=Marian C.|last8=Fazio|first8=Fabio|last9=Calarese|first9=Daniel|last10=Stevens|first10=James|last11=Razi|first11=Nahid|date=2004-12-07|title=Printed covalent glycan array for ligand profiling of diverse glycan binding proteins|journal=Proceedings of the National Academy of Sciences|language=en|volume=101|issue=49|pages=17033–17038|doi=10.1073/pnas.0407902101|issn=0027-8424|pmc=534418|pmid=15563589|bibcode=2004PNAS..10117033B|doi-access=free}}</ref><ref>{{Cite journal|last1=Walker|first1=Laura M.|last2=Huber|first2=Michael|last3=Doores|first3=Katie J.|author-link3=Katie Doores |last4=Falkowska|first4=Emilia|last5=Pejchal|first5=Robert|last6=Julien|first6=Jean-Philippe|last7=Wang|first7=Sheng-Kai|last8=Ramos|first8=Alejandra|last9=Chan-Hui|first9=Po-Ying|last10=Moyle|first10=Matthew|last11=Mitcham|first11=Jennifer L.|title=Broad neutralization coverage of HIV by multiple highly potent antibodies|journal=Nature|language=en|volume=477|issue=7365|pages=466–470|doi=10.1038/nature10373|issn=1476-4687|pmc=3393110|pmid=21849977|year=2011|bibcode=2011Natur.477..466W}}</ref><ref>{{Cite journal|last1=Pejchal|first1=R.|last2=Doores|first2=K. J.|author-link2=Katie Doores|last3=Walker|first3=L. M.|last4=Khayat|first4=R.|last5=Huang|first5=P.-S.|last6=Wang|first6=S.-K.|last7=Stanfield|first7=R. L.|last8=Julien|first8=J.-P.|last9=Ramos|first9=A.|last10=Crispin|first10=M.|last11=Depetris|first11=R.|date=2011-11-25|title=A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield|journal=Science|language=en|volume=334|issue=6059|pages=1097–1103|doi=10.1126/science.1213256|issn=0036-8075|pmc=3280215|pmid=21998254|bibcode=2011Sci...334.1097P}}</ref><ref>{{Cite journal|last1=Shivatare|first1=Sachin S.|last2=Chang|first2=Shih-Huang|last3=Tsai|first3=Tsung-I.|last4=Tseng|first4=Susan Yu|last5=Shivatare|first5=Vidya S.|last6=Lin|first6=Yih-Shyan|last7=Cheng|first7=Yang-Yu|last8=Ren|first8=Chien-Tai|last9=Lee|first9=Chang-Chun David|last10=Pawar|first10=Sujeet|last11=Tsai|first11=Charng-Sheng|title=Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies|journal=Nature Chemistry|language=en|volume=8|issue=4|pages=338–346|doi=10.1038/nchem.2463|issn=1755-4330|pmc=4806563|pmid=27001729|year=2016|bibcode=2016NatCh...8..338S}}</ref><ref>{{Cite journal|last1=Stewart-Jones|first1=Guillaume B.E.|last2=Soto|first2=Cinque|last3=Lemmin|first3=Thomas|last4=Chuang|first4=Gwo-Yu|last5=Druz|first5=Aliaksandr|last6=Kong|first6=Rui|last7=Thomas|first7=Paul V.|last8=Wagh|first8=Kshitij|last9=Zhou|first9=Tongqing|last10=Behrens|first10=Anna-Janina|last11=Bylund|first11=Tatsiana|title=Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G|journal=Cell|language=en|volume=165|issue=4|pages=813–826|doi=10.1016/j.cell.2016.04.010|pmc=5543418|pmid=27114034|year=2016}}</ref><ref>{{Cite journal|last1=Shivatare|first1=Vidya S.|last2=Shivatare|first2=Sachin S.|last3=Lee|first3=Chang-Chun David|last4=Liang|first4=Chi-Hui|last5=Liao|first5=Kuo-Shiang|last6=Cheng|first6=Yang-Yu|last7=Saidachary|first7=Gannerla|last8=Wu|first8=Chung-Yi|last9=Lin|first9=Nan-Horng|last10=Kwong|first10=Peter D.|last11=Burton|first11=Dennis R.|date=2018-04-18|title=Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies|journal=Journal of the American Chemical Society|volume=140|issue=15|pages=5202–5210|doi=10.1021/jacs.8b00896|pmid=29578688|issn=0002-7863}}</ref> for the high-throughput analysis of protein-carbohydrate interaction and the design of [[glycosylation]] probes<ref>{{Cite journal|last1=Sawa|first1=M.|last2=Hsu|first2=T.-L.|last3=Itoh|first3=T.|last4=Sugiyama|first4=M.|last5=Hanson|first5=S. R.|last6=Vogt|first6=P. K.|last7=Wong|first7=C.-H.|date=2006-08-15|title=Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo|journal=Proceedings of the National Academy of Sciences|language=en|volume=103|issue=33|pages=12371–12376|doi=10.1073/pnas.0605418103|issn=0027-8424|pmc=1567886|pmid=16895981|bibcode=2006PNAS..10312371S|doi-access=free}}</ref><ref>{{Cite journal|last1=Hsu|first1=Tsui-Ling|last2=Hanson|first2=Sarah R.|last3=Kishikawa|first3=Kuniyuki|last4=Wang|first4=Sheng-Kai|last5=Sawa|first5=Masaaki|last6=Wong|first6=Chi-Huey|date=2007-02-20|title=Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells|journal=Proceedings of the National Academy of Sciences|language=en|volume=104|issue=8|pages=2614–2619|doi=10.1073/pnas.0611307104|issn=0027-8424|pmid=17296930|pmc=1815231|bibcode=2007PNAS..104.2614H|doi-access=free}}</ref><ref>{{Cite journal|last1=Shie|first1=Jiun-Jie|last2=Liu|first2=Ying-Chih|last3=Lee|first3=Yu-Ming|last4=Lim|first4=Carmay|last5=Fang|first5=Jim-Min|last6=Wong|first6=Chi-Huey|date=2014-07-16|title=An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence upon Triazole Formation|journal=Journal of the American Chemical Society|volume=136|issue=28|pages=9953–9961|doi=10.1021/ja5010174|pmid=24955871|issn=0002-7863}}</ref> have enabled not only the fundamental study of glycosylation in biology<ref>{{Cite journal|last1=Hanson|first1=S. R.|last2=Culyba|first2=E. K.|last3=Hsu|first3=T.-L.|last4=Wong|first4=C.-H.|last5=Kelly|first5=J. W.|last6=Powers|first6=E. T.|date=2009-03-03|title=The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability|journal=Proceedings of the National Academy of Sciences|language=en|volume=106|issue=9|pages=3131–3136|doi=10.1073/pnas.0810318105|issn=0027-8424|pmc=2651298|pmid=19204290|bibcode=2009PNAS..106.3131H|doi-access=free}}</ref><ref>{{Cite journal|last1=Huang|first1=Yen-Wen|last2=Yang|first2=Hwai-I|last3=Wu|first3=Ying-Ta|last4=Hsu|first4=Tsui-Ling|last5=Lin|first5=Tzu-Wen|last6=Kelly|first6=Jeffery W.|last7=Wong|first7=Chi-Huey|date=2017-09-20|title=Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency|journal=Journal of the American Chemical Society|volume=139|issue=37|pages=12947–12955|doi=10.1021/jacs.7b03868|pmid=28820257|issn=0002-7863}}</ref><ref>{{Cite journal|last1=Krasnova|first1=Larissa|last2=Wong|first2=Chi-Huey|date=2016-06-02|title=Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis|journal=Annual Review of Biochemistry|language=en|volume=85|issue=1|pages=599–630|doi=10.1146/annurev-biochem-060614-034420|pmid=27145845|issn=0066-4154}}</ref><ref>{{Cite journal|last1=Krasnova|first1=Larissa|last2=Wong|first2=Chi-Huey|date=2019-03-06|title=Oligosaccharide Synthesis and Translational Innovation|journal=Journal of the American Chemical Society|volume=141|issue=9|pages=3735–3754|doi=10.1021/jacs.8b11005|issn=0002-7863|pmc=6538563|pmid=30716271}}</ref><ref>{{Cite journal|last1=Chuang|first1=Po-Kai|last2=Hsiao|first2=Michael|last3=Hsu|first3=Tsui-Ling|last4=Chang|first4=Chuan-Fa|last5=Wu|first5=Chung-Yi|last6=Chen|first6=Bo-Rui|last7=Huang|first7=Han-Wen|last8=Liao|first8=Kuo-Shiang|last9=Chen|first9=Chen-Chun|last10=Chen|first10=Chi-Long|last11=Yang|first11=Shun-Min|date=2019-02-26|title=Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer|journal=Proceedings of the National Academy of Sciences|language=en|volume=116|issue=9|pages=3518–3523|doi=10.1073/pnas.1816946116|issn=0027-8424|pmc=6397564|pmid=30808745|bibcode=2019PNAS..116.3518C |doi-access=free}}</ref> but also the clinical development of carbohydrate-based medicines, including vaccines and homogeneous antibodies for the treatment of cancers and [[infectious diseases]].<ref>{{Cite journal |last1=Huang |first1=Han-Yi |author-link= |last2=Liao |first2=Hsin-Yu |last3=Chen |first3=Xiaorui |last4=Wang |first4=Szu-Wen |last5=Wu |first5=Chung-Yi |last6=Jan |first6=Jia-Tsrong |last7=Cheng |first7=Ting-Jen Rachel |last8=Lin |first8=Kuo-I |last9=Ma |first9=Che |last10=Wong |first10=Chi-Huey |last11=Cheng |first11=Cheng-Wei |display-authors=10 |date=2022-04-06 |title=Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models |journal=Science Translational Medicine |volume=14 |issue=639 |pages=eabm0899 |bibcode= |doi=10.1126/scitranslmed.abm0899 |pmid=35230146|pmc=9802656 |s2cid=247168008 }}</ref><ref>{{Cite journal|last1=Tseng|first1=Yung-Chieh|last2=Wu|first2=Chia-Yu|last3=Liu|first3=Ming-Liang|last4=Chen|first4=Ting-Hua|last5=Chiang|first5=Wan-Ling|last6=Yu|first6=Yueh-Hsiang|last7=Jan|first7=Jia-Tsrong|last8=Lin|first8=Kuo-I|last9=Wong|first9=Chi-Huey|last10=Ma|first10=Che|date=2019-03-05|title=Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections|journal=Proceedings of the National Academy of Sciences|language=en|volume=116|issue=10|pages=4200–4205|doi=10.1073/pnas.1819197116|issn=0027-8424|pmc=6410868|pmid=30782805|bibcode=2019PNAS..116.4200T |doi-access=free}}</ref><ref>{{Cite journal|last1=Lin|first1=Chin-Wei|last2=Tsai|first2=Ming-Hung|last3=Li|first3=Shiou-Ting|last4=Tsai|first4=Tsung-I.|last5=Chu|first5=Kuo-Ching|last6=Liu|first6=Ying-Chih|last7=Lai|first7=Meng-Yu|last8=Wu|first8=Chia-Yu|last9=Tseng|first9=Yung-Chieh|last10=Shivatare|first10=Sachin S.|last11=Wang|first11=Chia-Hung|date=2015-08-25|title=A common glycan structure on immunoglobulin G for enhancement of effector functions|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=112|issue=34|pages=10611–10616|doi=10.1073/pnas.1513456112|issn=1091-6490|pmc=4553773|pmid=26253764|bibcode=2015PNAS..11210611L|doi-access=free}}</ref><ref>{{Cite journal|last1=Lo|first1=Hong-Jay|last2=Krasnova|first2=Larissa|last3=Dey|first3=Supriya|last4=Cheng|first4=Ting|last5=Liu|first5=Haitian|last6=Tsai|first6=Tsung-I|last7=Wu|first7=Kevin Binchia|last8=Wu|first8=Chung-Yi|last9=Wong|first9=Chi-Huey|date=2019-04-24|title=Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing α2,6-Linked 3Fax-Neu5Ac|journal=Journal of the American Chemical Society|volume=141|issue=16|pages=6484–6488|doi=10.1021/jacs.9b01991|pmid=30969765|s2cid=108292858 |issn=0002-7863|url=https://figshare.com/articles/Synthesis_of_Sialidase-Resistant_Oligosaccharide_and_Antibody_Glycoform_Containing_2_6-Linked_3F_sup_ax_sup_-Neu5Ac/7993568}}</ref><ref>{{Cite journal |last1=Lin |first1=Chih-Wei |last2=Wang |first2=Yu-Jen |last3=Lai |first3=Ting-Yen |last4=Hsu |first4=Tsui-Ling |last5=Han |first5=Shin-Ying |last6=Han-Chung |first6=Wu |last7=Shen |first7=Chia-Ning Shen |last8=Chen |first8=Ming-Wei |last9=Chen |first9=Lan-Bo |last10=Wong |first10=Chi-Huey |last11=Dang |first11=Van |display-authors=10 |date=2021-12-14 |title=Homogeneous antibody and CAR-T cells with improved effector functions targeting SSEA-4 glycan on pancreatic cancer |journal=Proceedings of the National Academy of Sciences |language=en |volume=118 |issue=50 |pages=e2114774118 |doi=10.1073/pnas.2114774118 |pmid=34876527|pmc=8685897 |bibcode=2021PNAS..11814774L |doi-access=free }}</ref>
Wong is best known for his original contributions to glycoscience, especially his development of [[Chemoenzymatic reaction|chemo-enzymatic]] methods for the practical synthesis of [[oligosaccharide]]s<ref>{{Cite journal|last=Wong|first=C.|date=1989-06-09|title=Enzymatic catalysts in organic synthesis|journal=Science|language=en|volume=244|issue=4909|pages=1145–1152|doi=10.1126/science.2658059|pmid=2658059|bibcode=1989Sci...244.1145W|issn=0036-8075}}</ref><ref>{{Cite journal|last1=Koeller|first1=Kathryn M.|last2=Wong|first2=Chi-Huey|title=Enzymes for chemical synthesis|journal=Nature|language=en|volume=409|issue=6817|pages=232–240|doi=10.1038/35051706|pmid=11196651|issn=0028-0836|year=2001|bibcode=2001Natur.409..232K|s2cid=4339585}}</ref><ref>{{Cite journal|last=Sears|first=P.|date=2001-03-23|title=Toward Automated Synthesis of Oligosaccharides and Glycoproteins|journal=Science|volume=291|issue=5512|pages=2344–2350|doi=10.1126/science.1058899|pmid=11269314|bibcode=2001Sci...291.2344S|s2cid=25853502}}</ref><ref>{{Cite journal|last1=Machajewski|first1=Timothy D.|last2=Wong|first2=Chi-Huey|date=2000|title=The Catalytic Asymmetric Aldol Reaction|journal=Angewandte Chemie International Edition|language=en|volume=39|issue=8|pages=1352–1375|doi=10.1002/(sici)1521-3773(20000417)39:8<1352::aid-anie1352>3.0.co;2-j|pmid=10777624|issn=1521-3773}}</ref><ref>{{Cite journal|last1=Ichikawa|first1=Yoshitaka|last2=Lin|first2=Ying Chih|last3=Dumas|first3=David P.|last4=Shen|first4=Gwo Jenn|last5=Garcia-Junceda|first5=Eduardo|last6=Williams|first6=Mark A.|last7=Bayer|first7=Robert|last8=Ketcham|first8=Catherine|last9=Walker|first9=Leslie E.|date=1992-11-01|title=Chemical-enzymic synthesis and conformational analysis of sialyl Lewis X and derivatives|journal=Journal of the American Chemical Society|volume=114|issue=24|pages=9283–9298|doi=10.1021/ja00050a007|issn=0002-7863}}</ref> and [[glycoprotein]]s<ref>{{Cite journal|last1=Koeller|first1=Kathryn M.|last2=Wong|first2=Chi-Huey|title=Enzymes for chemical synthesis|journal=Nature|language=en|volume=409|issue=6817|pages=232–240|doi=10.1038/35051706|pmid=11196651|issn=0028-0836|year=2001|bibcode=2001Natur.409..232K|s2cid=4339585}}</ref><ref>{{Cite journal |last1=Sears |first1=P. |last2=Wong |first2=Chi-Huey |date=2001-03-23 |title=Toward Automated Synthesis of Oligosaccharides and Glycoproteins |journal=Science |volume=291 |issue=5512 |pages=2344–2350 |bibcode=2001Sci...291.2344S |doi=10.1126/science.1058899 |pmid=11269314 |s2cid=25853502}}</ref><ref>{{Cite journal|last1=Witte|first1=Krista|last2=Sears|first2=Pamela|last3=Martin|first3=Richard|last4=Wong|first4=Chi-Huey|date=1997-03-01|title=Enzymatic Glycoprotein Synthesis: Preparation of Ribonuclease Glycoforms via Enzymatic Glycopeptide Condensation and Glycosylation|journal=Journal of the American Chemical Society|volume=119|issue=9|pages=2114–2118|doi=10.1021/ja961846z|issn=0002-7863}}</ref><ref>{{Cite journal|last1=Brik|first1=Ashraf|last2=Ficht|first2=Simon|last3=Yang|first3=Yu-Ying|last4=Wong|first4=Chi-Huey|date=2006-11-01|title=Sugar-Assisted Ligation of N-Linked Glycopeptides with Broad Sequence Tolerance at the Ligation Junction|journal=Journal of the American Chemical Society|volume=128|issue=46|pages=15026–15033|doi=10.1021/ja065601q|pmid=17105315|issn=0002-7863|url=http://ntur.lib.ntu.edu.tw/bitstream/246246/218234/-1/28.pdf }}</ref><ref>{{Cite journal|last1=Payne|first1=Richard J.|last2=Wong|first2=Chi-Huey|date=2010-01-07|title=Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins|journal=Chemical Communications|language=en|volume=46|issue=1|pages=21–43|doi=10.1039/B913845E|pmid=20024291|issn=1364-548X}}</ref> and the hierarchical and programmable one-pot synthesis method for the rapid preparation of a large number of oligosaccharides.<ref>{{Cite journal|last1=Galan|first1=M. Carmen|last2=Benito-Alifonso|first2=David|last3=Watt|first3=Gregory M.|date=2011-05-21|title=Carbohydrate chemistry in drug discovery|journal=Organic & Biomolecular Chemistry|language=en|volume=9|issue=10|pages=3598–3610|doi=10.1039/C0OB01017K|pmid=21409288|issn=1477-0539}}</ref> The original synthetic methods developed by Wong along with his work on the development of glycan microarrays<ref>{{Cite journal|last1=Fazio|first1=Fabio|last2=Bryan|first2=Marian C.|last3=Blixt|first3=Ola|last4=Paulson|first4=James C.|last5=Wong|first5=Chi-Huey|date=2002-12-01|title=Synthesis of Sugar Arrays in Microtiter Plate|journal=Journal of the American Chemical Society|volume=124|issue=48|pages=14397–14402|doi=10.1021/ja020887u|pmid=12452714|issn=0002-7863|url=https://figshare.com/articles/journal_contribution/3641553}}</ref><ref>{{Cite journal|last1=Blixt|first1=Ola|last2=Head|first2=Steve|last3=Mondala|first3=Tony|last4=Scanlan|first4=Christopher|last5=Huflejt|first5=Margaret E.|last6=Alvarez|first6=Richard|last7=Bryan|first7=Marian C.|last8=Fazio|first8=Fabio|last9=Calarese|first9=Daniel|last10=Stevens|first10=James|last11=Razi|first11=Nahid|date=2004-12-07|title=Printed covalent glycan array for ligand profiling of diverse glycan binding proteins|journal=Proceedings of the National Academy of Sciences|language=en|volume=101|issue=49|pages=17033–17038|doi=10.1073/pnas.0407902101|issn=0027-8424|pmc=534418|pmid=15563589|bibcode=2004PNAS..10117033B|doi-access=free}}</ref><ref>{{Cite journal|last1=Walker|first1=Laura M.|last2=Huber|first2=Michael|last3=Doores|first3=Katie J.|author-link3=Katie Doores |last4=Falkowska|first4=Emilia|last5=Pejchal|first5=Robert|last6=Julien|first6=Jean-Philippe|last7=Wang|first7=Sheng-Kai|last8=Ramos|first8=Alejandra|last9=Chan-Hui|first9=Po-Ying|last10=Moyle|first10=Matthew|last11=Mitcham|first11=Jennifer L.|title=Broad neutralization coverage of HIV by multiple highly potent antibodies|journal=Nature|language=en|volume=477|issue=7365|pages=466–470|doi=10.1038/nature10373|issn=1476-4687|pmc=3393110|pmid=21849977|year=2011|bibcode=2011Natur.477..466W}}</ref><ref>{{Cite journal|last1=Pejchal|first1=R.|last2=Doores|first2=K. J.|author-link2=Katie Doores|last3=Walker|first3=L. M.|last4=Khayat|first4=R.|last5=Huang|first5=P.-S.|last6=Wang|first6=S.-K.|last7=Stanfield|first7=R. 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R.|last6=Vogt|first6=P. K.|last7=Wong|first7=C.-H.|date=2006-08-15|title=Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo|journal=Proceedings of the National Academy of Sciences|language=en|volume=103|issue=33|pages=12371–12376|doi=10.1073/pnas.0605418103|issn=0027-8424|pmc=1567886|pmid=16895981|bibcode=2006PNAS..10312371S|doi-access=free}}</ref><ref>{{Cite journal|last1=Hsu|first1=Tsui-Ling|last2=Hanson|first2=Sarah R.|last3=Kishikawa|first3=Kuniyuki|last4=Wang|first4=Sheng-Kai|last5=Sawa|first5=Masaaki|last6=Wong|first6=Chi-Huey|date=2007-02-20|title=Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells|journal=Proceedings of the National Academy of Sciences|language=en|volume=104|issue=8|pages=2614–2619|doi=10.1073/pnas.0611307104|issn=0027-8424|pmid=17296930|pmc=1815231|bibcode=2007PNAS..104.2614H|doi-access=free}}</ref><ref>{{Cite journal|last1=Shie|first1=Jiun-Jie|last2=Liu|first2=Ying-Chih|last3=Lee|first3=Yu-Ming|last4=Lim|first4=Carmay|last5=Fang|first5=Jim-Min|last6=Wong|first6=Chi-Huey|date=2014-07-16|title=An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence upon Triazole Formation|journal=Journal of the American Chemical Society|volume=136|issue=28|pages=9953–9961|doi=10.1021/ja5010174|pmid=24955871|issn=0002-7863}}</ref> have enabled not only the fundamental study of glycosylation in biology<ref>{{Cite journal|last1=Hanson|first1=S. R.|last2=Culyba|first2=E. K.|last3=Hsu|first3=T.-L.|last4=Wong|first4=C.-H.|last5=Kelly|first5=J. W.|last6=Powers|first6=E. T.|date=2009-03-03|title=The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability|journal=Proceedings of the National Academy of Sciences|language=en|volume=106|issue=9|pages=3131–3136|doi=10.1073/pnas.0810318105|issn=0027-8424|pmc=2651298|pmid=19204290|bibcode=2009PNAS..106.3131H|doi-access=free}}</ref><ref>{{Cite journal|last1=Huang|first1=Yen-Wen|last2=Yang|first2=Hwai-I|last3=Wu|first3=Ying-Ta|last4=Hsu|first4=Tsui-Ling|last5=Lin|first5=Tzu-Wen|last6=Kelly|first6=Jeffery W.|last7=Wong|first7=Chi-Huey|date=2017-09-20|title=Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency|journal=Journal of the American Chemical Society|volume=139|issue=37|pages=12947–12955|doi=10.1021/jacs.7b03868|pmid=28820257|issn=0002-7863}}</ref><ref>{{Cite journal|last1=Krasnova|first1=Larissa|last2=Wong|first2=Chi-Huey|date=2016-06-02|title=Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis|journal=Annual Review of Biochemistry|language=en|volume=85|issue=1|pages=599–630|doi=10.1146/annurev-biochem-060614-034420|pmid=27145845|issn=0066-4154|doi-access=free}}</ref><ref>{{Cite journal|last1=Krasnova|first1=Larissa|last2=Wong|first2=Chi-Huey|date=2019-03-06|title=Oligosaccharide Synthesis and Translational Innovation|journal=Journal of the American Chemical Society|volume=141|issue=9|pages=3735–3754|doi=10.1021/jacs.8b11005|issn=0002-7863|pmc=6538563|pmid=30716271}}</ref><ref>{{Cite journal|last1=Chuang|first1=Po-Kai|last2=Hsiao|first2=Michael|last3=Hsu|first3=Tsui-Ling|last4=Chang|first4=Chuan-Fa|last5=Wu|first5=Chung-Yi|last6=Chen|first6=Bo-Rui|last7=Huang|first7=Han-Wen|last8=Liao|first8=Kuo-Shiang|last9=Chen|first9=Chen-Chun|last10=Chen|first10=Chi-Long|last11=Yang|first11=Shun-Min|date=2019-02-26|title=Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer|journal=Proceedings of the National Academy of Sciences|language=en|volume=116|issue=9|pages=3518–3523|doi=10.1073/pnas.1816946116|issn=0027-8424|pmc=6397564|pmid=30808745|bibcode=2019PNAS..116.3518C |doi-access=free}}</ref> but also the clinical development of carbohydrate-based medicines, including vaccines and homogeneous antibodies for the treatment of cancers and [[infectious diseases]].<ref>{{Cite journal |last1=Huang |first1=Han-Yi |author-link= |last2=Liao |first2=Hsin-Yu |last3=Chen |first3=Xiaorui |last4=Wang |first4=Szu-Wen |last5=Wu |first5=Chung-Yi |last6=Jan |first6=Jia-Tsrong |last7=Cheng |first7=Ting-Jen Rachel |last8=Lin |first8=Kuo-I |last9=Ma |first9=Che |last10=Wong |first10=Chi-Huey |last11=Cheng |first11=Cheng-Wei |display-authors=10 |date=2022-04-06 |title=Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models |journal=Science Translational Medicine |volume=14 |issue=639 |pages=eabm0899 |bibcode= |doi=10.1126/scitranslmed.abm0899 |pmid=35230146|pmc=9802656 |s2cid=247168008 }}</ref><ref>{{Cite journal|last1=Tseng|first1=Yung-Chieh|last2=Wu|first2=Chia-Yu|last3=Liu|first3=Ming-Liang|last4=Chen|first4=Ting-Hua|last5=Chiang|first5=Wan-Ling|last6=Yu|first6=Yueh-Hsiang|last7=Jan|first7=Jia-Tsrong|last8=Lin|first8=Kuo-I|last9=Wong|first9=Chi-Huey|last10=Ma|first10=Che|date=2019-03-05|title=Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections|journal=Proceedings of the National Academy of Sciences|language=en|volume=116|issue=10|pages=4200–4205|doi=10.1073/pnas.1819197116|issn=0027-8424|pmc=6410868|pmid=30782805|bibcode=2019PNAS..116.4200T |doi-access=free}}</ref><ref>{{Cite journal|last1=Lin|first1=Chin-Wei|last2=Tsai|first2=Ming-Hung|last3=Li|first3=Shiou-Ting|last4=Tsai|first4=Tsung-I.|last5=Chu|first5=Kuo-Ching|last6=Liu|first6=Ying-Chih|last7=Lai|first7=Meng-Yu|last8=Wu|first8=Chia-Yu|last9=Tseng|first9=Yung-Chieh|last10=Shivatare|first10=Sachin S.|last11=Wang|first11=Chia-Hung|date=2015-08-25|title=A common glycan structure on immunoglobulin G for enhancement of effector functions|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=112|issue=34|pages=10611–10616|doi=10.1073/pnas.1513456112|issn=1091-6490|pmc=4553773|pmid=26253764|bibcode=2015PNAS..11210611L|doi-access=free}}</ref><ref>{{Cite journal|last1=Lo|first1=Hong-Jay|last2=Krasnova|first2=Larissa|last3=Dey|first3=Supriya|last4=Cheng|first4=Ting|last5=Liu|first5=Haitian|last6=Tsai|first6=Tsung-I|last7=Wu|first7=Kevin Binchia|last8=Wu|first8=Chung-Yi|last9=Wong|first9=Chi-Huey|date=2019-04-24|title=Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing α2,6-Linked 3Fax-Neu5Ac|journal=Journal of the American Chemical Society|volume=141|issue=16|pages=6484–6488|doi=10.1021/jacs.9b01991|pmid=30969765|s2cid=108292858 |issn=0002-7863|url=https://figshare.com/articles/Synthesis_of_Sialidase-Resistant_Oligosaccharide_and_Antibody_Glycoform_Containing_2_6-Linked_3F_sup_ax_sup_-Neu5Ac/7993568}}</ref><ref>{{Cite journal |last1=Lin |first1=Chih-Wei |last2=Wang |first2=Yu-Jen |last3=Lai |first3=Ting-Yen |last4=Hsu |first4=Tsui-Ling |last5=Han |first5=Shin-Ying |last6=Han-Chung |first6=Wu |last7=Shen |first7=Chia-Ning Shen |last8=Chen |first8=Ming-Wei |last9=Chen |first9=Lan-Bo |last10=Wong |first10=Chi-Huey |last11=Dang |first11=Van |display-authors=10 |date=2021-12-14 |title=Homogeneous antibody and CAR-T cells with improved effector functions targeting SSEA-4 glycan on pancreatic cancer |journal=Proceedings of the National Academy of Sciences |language=en |volume=118 |issue=50 |pages=e2114774118 |doi=10.1073/pnas.2114774118 |pmid=34876527|pmc=8685897 |bibcode=2021PNAS..11814774L |doi-access=free }}</ref>


In 2016, there was a media report, speculating that he was possibly involved in an insider trading scandal related to a biotech company [[OBI Pharma, Inc.]] headquartered in Taiwan, because his adult daughter had held shares in OBI Pharma.<ref>{{cite news |last1=Loa |first1=Lok-sin |date=31 March 2016 |title=Wong Chi-huey offers resignation |work=Taipei Times |url=http://www.taipeitimes.com/News/taiwan/archives/2016/03/31/2003642854 |access-date=25 April 2016}}</ref> When the allegations surfaced in March 2016, Wong was in the United States. He was quite disappointed by the false report and attempted to resign his position as president of the Academia Sinica twice. Both requests were rejected by the president of Taiwan, [[Ma Ying-jeou]]. After further consideration, Ma chose to approve Wong's resignation on 10 May.<ref>{{cite news|last1=Normile|first1=Dennis|title=Head of Taiwan's Academia Sinica resigns|url=https://www.science.org/content/article/head-taiwans-academia-sinica-resigns|access-date=21 February 2018|work=Science Magazine|date=11 May 2016}}</ref> In February 2018, the Shilin District Prosecutors Office announced that charges of insider trading against Wong had been dropped, though an investigation into a possible failure in disclosing his assets during tech transfer of his invention had not yet concluded by the Control Yuan.<ref>{{cite news|last1=Kao|first1=Evelyn|last2=Hsiao|first2=Po-wen|title=Insider trading charges dropped against ex-Academia Sinica head|url=http://focustaiwan.tw/news/asoc/201802210032.aspx|access-date=22 February 2018|agency=Central News Agency|date=21 February 2018}}</ref> In April 2022, the Control Yuan publicly announced that Wong did not violate any rule.<ref>{{cite news |last1=Lin |first1=Liang-sheng |last2=Chung |first2=Jake |title=Wong Chi-huey deserves retrial, Control Yuan says |url=https://taipeitimes.com/News/taiwan/archives/2022/04/12/2003776461 |access-date=12 April 2022 |work=Taipei Times |date=12 April 2022}}</ref>
In 2016, there was a media report, speculating that he was possibly involved in an insider trading scandal related to a biotech company [[OBI Pharma, Inc.]] headquartered in Taiwan, because his adult daughter had held shares in OBI Pharma.<ref>{{cite news |last1=Loa |first1=Lok-sin |date=31 March 2016 |title=Wong Chi-huey offers resignation |work=Taipei Times |url=http://www.taipeitimes.com/News/taiwan/archives/2016/03/31/2003642854 |access-date=25 April 2016}}</ref> When the allegations surfaced in March 2016, Wong was in the United States. He was quite disappointed by the false report and attempted to resign his position as president of the Academia Sinica twice. Both requests were rejected by the president of Taiwan, [[Ma Ying-jeou]]. After further consideration, Ma chose to approve Wong's resignation on 10 May.<ref>{{cite news|last1=Normile|first1=Dennis|title=Head of Taiwan's Academia Sinica resigns|url=https://www.science.org/content/article/head-taiwans-academia-sinica-resigns|access-date=21 February 2018|work=Science Magazine|date=11 May 2016}}</ref> In February 2018, the Shilin District Prosecutors Office announced that charges of insider trading against Wong had been dropped, though an investigation into a possible failure in disclosing his assets during tech transfer of his invention had not yet concluded by the Control Yuan.<ref>{{cite news|last1=Kao|first1=Evelyn|last2=Hsiao|first2=Po-wen|title=Insider trading charges dropped against ex-Academia Sinica head|url=http://focustaiwan.tw/news/asoc/201802210032.aspx|access-date=22 February 2018|agency=Central News Agency|date=21 February 2018}}</ref> In April 2022, the Control Yuan publicly announced that Wong did not violate any rule.<ref>{{cite news |last1=Lin |first1=Liang-sheng |last2=Chung |first2=Jake |title=Wong Chi-huey deserves retrial, Control Yuan says |url=https://taipeitimes.com/News/taiwan/archives/2022/04/12/2003776461 |access-date=12 April 2022 |work=Taipei Times |date=12 April 2022}}</ref>


==Recognition==
==Awards and honors==
===Awards===
*1985 – Searle Scholar Award
*1985 – Searle Scholar Award
*1986 – [[Presidential Young Investigator Award]] in Chemistry
*1986 – [[Presidential Young Investigator Award]] in Chemistry
Line 56: Line 46:
*2012 – [[Arthur C. Cope Award]]<ref>{{Cite web|url=https://www.asianscientist.com/2011/09/academia/academia-sinica-president-chi-huey-wong-2012-arthur-c-cope-award/|title=Academia Sinica President Chi-Huey Wong To Receive 2012 Arthur C. Cope Award|date=2011-09-08|website=Asian Scientist Magazine |access-date=2019-10-23}}</ref> by the [[American Chemical Society]].
*2012 – [[Arthur C. Cope Award]]<ref>{{Cite web|url=https://www.asianscientist.com/2011/09/academia/academia-sinica-president-chi-huey-wong-2012-arthur-c-cope-award/|title=Academia Sinica President Chi-Huey Wong To Receive 2012 Arthur C. Cope Award|date=2011-09-08|website=Asian Scientist Magazine |access-date=2019-10-23}}</ref> by the [[American Chemical Society]].
*2014 – [[Wolf Prize in Chemistry]]<ref>[https://wolffund.org.il/2018/12/12/chi-huey-wong/ Wolf Prize in Chemistry 2014]</ref>
*2014 – [[Wolf Prize in Chemistry]]<ref>[https://wolffund.org.il/2018/12/12/chi-huey-wong/ Wolf Prize in Chemistry 2014]</ref>
*2015 – Robert Robinson Award, [[Royal Society of Chemistry]]<ref>{{Cite web|url=http://www.genomics.sinica.edu.tw/index.php/en/news/awards-a-honors/453-academia-sinica-president-chi-huey-wong-receives-2015-robert-robinson-award|title=Academia Sinica President Chi-Huey Wong Receives 2015 Robert Robinson Award|website=www.genomics.sinica.edu.tw|access-date=2019-10-23}}</ref>
*2015 – Robert Robinson Award, [[Royal Society of Chemistry]]<ref>{{Cite web|url=http://www.genomics.sinica.edu.tw/index.php/en/news/awards-a-honors/453-academia-sinica-president-chi-huey-wong-receives-2015-robert-robinson-award|title=Academia Sinica President Chi-Huey Wong Receives 2015 Robert Robinson Award|website=www.genomics.sinica.edu.tw|access-date=2019-10-23|archive-date=2015-05-12|archive-url=https://web.archive.org/web/20150512011412/http://www.genomics.sinica.edu.tw/index.php/en/news/awards-a-honors/453-academia-sinica-president-chi-huey-wong-receives-2015-robert-robinson-award|url-status=dead}}</ref>
*2021 – [[Welch Award in Chemistry]]<ref>[https://welch1.org/awards/welch-award-in-chemistry Welch Award in Chemistry] 2021</ref>
*2021 – [[Welch Award in Chemistry]]<ref>[https://welch1.org/awards/welch-award-in-chemistry Welch Award in Chemistry] 2021</ref>
*2022 – [[Chemical Pioneer Award]] of the [[American Institute of Chemists]]<ref>{{cite news |last1=Wu |first1=Hsin-yun |last2=Shih |first2=Hsiu-chuan |title=Taiwanese biochemist Wong Chi-huey receives Chemical Pioneer Award |url=https://focustaiwan.tw/sci-tech/202204120013 |access-date=13 April 2022 |agency=Central News Agency |date=12 April 2022}} Republished as: {{cite news |title=Biochemist receives US 'Pioneer' award |url=https://taipeitimes.com/News/taiwan/archives/2022/04/13/2003776523 |access-date=13 April 2022 |work=Taipei Times |date=13 April 2022}}</ref>
*2022 – [[Chemical Pioneer Award]] of the [[American Institute of Chemists]]<ref>{{cite news |last1=Wu |first1=Hsin-yun |last2=Shih |first2=Hsiu-chuan |title=Taiwanese biochemist Wong Chi-huey receives Chemical Pioneer Award |url=https://focustaiwan.tw/sci-tech/202204120013 |access-date=13 April 2022 |agency=Central News Agency |date=12 April 2022}} Republished as: {{cite news |title=Biochemist receives US 'Pioneer' award |url=https://taipeitimes.com/News/taiwan/archives/2022/04/13/2003776523 |access-date=13 April 2022 |work=Taipei Times |date=13 April 2022}}</ref>
*2023 – Israel Chemical Society International Barry Cohen Award
*2023 – Israel Chemical Society International Barry Cohen Award
*2023 – [[Federation of Asian Chemical Societies]] (FACS) Foundation Lectureship Award
*2023 – [[Federation of Asian Chemical Societies]] (FACS) Foundation Lectureship Award

===Honorary doctorates===
*2007 – [[Technion – Israel Institute of Technology]], Israel
*2007 – [[National Yang-Ming University]], Taiwan (now [[NYCU]])
*2008 – [[National Sun Yat-sen University]], Taiwan
*2009 – [[City University of Hong Kong]], Hong Kong SAR
*2010 – [[National Chung Hsing University]], Taiwan
*2011 – [[National Chiao Tung University]], Taiwan (now [[NYCU]])
⚫
*2011 – [[National Tsing-Hua University]], Taiwan


==Memberships==
==Memberships==
Line 89: Line 88:
[[Category:Living people]]
[[Category:Living people]]
[[Category:20th-century American biochemists]]
[[Category:20th-century American biochemists]]
[[Category:21st-century American chemists]]
[[Category:21st-century American biochemists]]
⚫
[[Category:American biochemists]]
[[Category:Massachusetts Institute of Technology School of Science alumni]]
[[Category:Massachusetts Institute of Technology School of Science alumni]]
[[Category:Members of Academia Sinica]]
[[Category:Members of Academia Sinica]]
Line 102: Line 100:
[[Category:Texas A&M University faculty]]
[[Category:Texas A&M University faculty]]
[[Category:Winners of the Nikkei Asia Prize]]
[[Category:Winners of the Nikkei Asia Prize]]
⚫
[[Category:American scientists of Asian descent]]

Latest revision as of 03:34, 8 September 2024

The native form of this personal name is Wong Chi-Huey. This article uses Western name order when mentioning individuals.
Chi-Huey Wong
翁啟惠
Wong in 2021
8th President of the Academia Sinica
In office
19 October 2006 – 10 May 2016
Vice PresidentAndrew H. J. Wang
Chen Chien-jen
Wang Yu
Wang Fan-sen
Preceded byYuan T. Lee
Succeeded byWang Fan-sen (acting)
Personal details
Born (1948-08-03) August 3, 1948 (age 76)
Yizhu, Tainan County, Taiwan (now Chiayi County)
EducationNational Taiwan University (BS, MS)
Massachusetts Institute of Technology (PhD)

Chi-Huey Wong (Chinese: 翁啟惠; born 3 August 1948) is a Taiwanese-American biochemist. He is currently the Scripps Family Chair Professor at the Scripps Research Institute.[1] He is a member of the United States National Academy of Sciences, as awarded the 2014 Wolf Prize in Chemistry and 2015 RSC Robert Robinson Award.[2] Wong is also the holder of more than 100 patents and publisher of 700 more scholarly academic research papers under his name.[3]

Education

[edit]

Wong earned his Bachelor of Science (B.S.) and Master of Science (M.S.) in biochemical sciences from National Taiwan University in Taipei. He then received a Ph.D. in chemistry in 1982 from the Massachusetts Institute of Technology (MIT) under the direction of George M. Whitesides. At MIT, he studied the use of enzymes as catalysts in organic synthesis.[4]

Research and career

[edit]

Wong continued his postdoctoral research work with George M. Whitesides at Harvard University from 1982 to 1983, then began his independent career at Texas A&M University in the chemistry department. During his tenure at Texas A&M University, he went through the ranks including assistant professor, associate professor, and professor of chemistry.

Wong was appointed as the Ernest W. Hahn Chair and professor of chemistry at the Scripps Research Institute and while he was a faculty member at Scripps, he also served as head of the Frontier Research Program on Glycotechnology at Riken in Japan[5] and director of the Genomics Research Center at Academia Sinica,[6] and was later appointed by the President of the Republic of China (Taiwan) as the President of Academia Sinica. Now, he is  serving at the Scripps Research Institute as Scripps Family Chair Professor of Chemistry.[7]

Wong is best known for his original contributions to glycoscience, especially his development of chemo-enzymatic methods for the practical synthesis of oligosaccharides[8][9][10][11][12] and glycoproteins[13][14][15][16][17] and the hierarchical and programmable one-pot synthesis method for the rapid preparation of a large number of oligosaccharides.[18] The original synthetic methods developed by Wong along with his work on the development of glycan microarrays[19][20][21][22][23][24][25] for the high-throughput analysis of protein-carbohydrate interaction and the design of glycosylation probes[26][27][28] have enabled not only the fundamental study of glycosylation in biology[29][30][31][32][33] but also the clinical development of carbohydrate-based medicines, including vaccines and homogeneous antibodies for the treatment of cancers and infectious diseases.[34][35][36][37][38]

In 2016, there was a media report, speculating that he was possibly involved in an insider trading scandal related to a biotech company OBI Pharma, Inc. headquartered in Taiwan, because his adult daughter had held shares in OBI Pharma.[39] When the allegations surfaced in March 2016, Wong was in the United States. He was quite disappointed by the false report and attempted to resign his position as president of the Academia Sinica twice. Both requests were rejected by the president of Taiwan, Ma Ying-jeou. After further consideration, Ma chose to approve Wong's resignation on 10 May.[40] In February 2018, the Shilin District Prosecutors Office announced that charges of insider trading against Wong had been dropped, though an investigation into a possible failure in disclosing his assets during tech transfer of his invention had not yet concluded by the Control Yuan.[41] In April 2022, the Control Yuan publicly announced that Wong did not violate any rule.[42]

Recognition

[edit]

Awards

[edit]

Honorary doctorates

[edit]

Memberships

[edit]

Wong was elected as a member of the Academia Sinica in 1994, the American Academy of Arts and Science in 1996, the United States National Academy of Sciences in 2002, the World Academy of Sciences in 2007, the United States National Academy of Inventors in 2014, and also an Associate Member of the European Molecular Biology Organization in 2010.[49]

Bibliography

[edit]
  • Enzymes in Synthetic Organic Chemistry. Pergamon Press. 1994. ISBN 978-0-08-050582-4
  • Carbohydrate Based Drug Discovery. Wiley Online Library. 2003. ISBN 978-3-527-60243-8
  • Current Status and New Challenges in Glycoscience. Springer. ISBN 978-4-431-54841-6

Patents

[edit]

Wong obtained many patents for his inventions. His representative patents include Globo-H and related anti-cancer vaccines with novel glycolipid adjuvants (US9,603,913B2), Glycan arrays on PTFE-like aluminum coated glass slides and related methods (US8,680,020), Methods and compositions for immunization against virus (US8.741,311), Large scale enzymatic synthesis of oligosaccharides (US9,340,812), Methods for modifying human antibodies by glycan engineering (US10, 087,236), Compositions and methods relating to universal glycoforms for enhanced antibody efficacy (US10,023892), Crystal structure of bifunctional transglycosylase PBP1b from E. Coli and inhibitors thereof (US9890111B2),[50] Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants (US-8906832-B2),[51] Antibiotic compositions and related screening methods (US8916540B2),[52] Hirsutella Sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses (US8486914B2),[53] and Tailored glycoproteomic methods for the sequencing, mapping and identification of cellular glycoproteins (US7943330B2).[54]

References

[edit]
  1. ^ "Chi-Huey Wong | Scripps Research". www.scripps.edu. Retrieved 2019-10-14.
  2. ^ "RSC Robert Robinson Award 2015 Winner". www.rsc.org. Retrieved 2019-10-14.
  3. ^ "Chi-Huey Wong – Google Scholar Citations". scholar.google.com.tw. Retrieved 2019-10-14.
  4. ^ "Dr. Chi-Huey Wong's Personal Webpage". www.genomics.sinica.edu.tw. Archived from the original on 2016-04-04. Retrieved 2019-10-14.
  5. ^ "Third RIKEN-Academia Sinica Joint Conference | RIKEN". www.riken.jp. Retrieved 2019-10-23.
  6. ^ "Dr. Chi-Huey Wong's Personal Webpage". www.genomics.sinica.edu.tw. Archived from the original on 2016-04-04. Retrieved 2019-10-23.
  7. ^ "70th Birthday: Chi-Huey Wong :: ChemViews Magazine :: ChemistryViews". www.chemistryviews.org. 3 August 2018. Retrieved 2019-10-23.
  8. ^ Wong, C. (1989-06-09). "Enzymatic catalysts in organic synthesis". Science. 244 (4909): 1145–1152. Bibcode:1989Sci...244.1145W. doi:10.1126/science.2658059. ISSN 0036-8075. PMID 2658059.
  9. ^ Koeller, Kathryn M.; Wong, Chi-Huey (2001). "Enzymes for chemical synthesis". Nature. 409 (6817): 232–240. Bibcode:2001Natur.409..232K. doi:10.1038/35051706. ISSN 0028-0836. PMID 11196651. S2CID 4339585.
  10. ^ Sears, P. (2001-03-23). "Toward Automated Synthesis of Oligosaccharides and Glycoproteins". Science. 291 (5512): 2344–2350. Bibcode:2001Sci...291.2344S. doi:10.1126/science.1058899. PMID 11269314. S2CID 25853502.
  11. ^ Machajewski, Timothy D.; Wong, Chi-Huey (2000). "The Catalytic Asymmetric Aldol Reaction". Angewandte Chemie International Edition. 39 (8): 1352–1375. doi:10.1002/(sici)1521-3773(20000417)39:8<1352::aid-anie1352>3.0.co;2-j. ISSN 1521-3773. PMID 10777624.
  12. ^ Ichikawa, Yoshitaka; Lin, Ying Chih; Dumas, David P.; Shen, Gwo Jenn; Garcia-Junceda, Eduardo; Williams, Mark A.; Bayer, Robert; Ketcham, Catherine; Walker, Leslie E. (1992-11-01). "Chemical-enzymic synthesis and conformational analysis of sialyl Lewis X and derivatives". Journal of the American Chemical Society. 114 (24): 9283–9298. doi:10.1021/ja00050a007. ISSN 0002-7863.
  13. ^ Koeller, Kathryn M.; Wong, Chi-Huey (2001). "Enzymes for chemical synthesis". Nature. 409 (6817): 232–240. Bibcode:2001Natur.409..232K. doi:10.1038/35051706. ISSN 0028-0836. PMID 11196651. S2CID 4339585.
  14. ^ Sears, P.; Wong, Chi-Huey (2001-03-23). "Toward Automated Synthesis of Oligosaccharides and Glycoproteins". Science. 291 (5512): 2344–2350. Bibcode:2001Sci...291.2344S. doi:10.1126/science.1058899. PMID 11269314. S2CID 25853502.
  15. ^ Witte, Krista; Sears, Pamela; Martin, Richard; Wong, Chi-Huey (1997-03-01). "Enzymatic Glycoprotein Synthesis: Preparation of Ribonuclease Glycoforms via Enzymatic Glycopeptide Condensation and Glycosylation". Journal of the American Chemical Society. 119 (9): 2114–2118. doi:10.1021/ja961846z. ISSN 0002-7863.
  16. ^ Brik, Ashraf; Ficht, Simon; Yang, Yu-Ying; Wong, Chi-Huey (2006-11-01). "Sugar-Assisted Ligation of N-Linked Glycopeptides with Broad Sequence Tolerance at the Ligation Junction" (PDF). Journal of the American Chemical Society. 128 (46): 15026–15033. doi:10.1021/ja065601q. ISSN 0002-7863. PMID 17105315.
  17. ^ Payne, Richard J.; Wong, Chi-Huey (2010-01-07). "Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins". Chemical Communications. 46 (1): 21–43. doi:10.1039/B913845E. ISSN 1364-548X. PMID 20024291.
  18. ^ Galan, M. Carmen; Benito-Alifonso, David; Watt, Gregory M. (2011-05-21). "Carbohydrate chemistry in drug discovery". Organic & Biomolecular Chemistry. 9 (10): 3598–3610. doi:10.1039/C0OB01017K. ISSN 1477-0539. PMID 21409288.
  19. ^ Fazio, Fabio; Bryan, Marian C.; Blixt, Ola; Paulson, James C.; Wong, Chi-Huey (2002-12-01). "Synthesis of Sugar Arrays in Microtiter Plate". Journal of the American Chemical Society. 124 (48): 14397–14402. doi:10.1021/ja020887u. ISSN 0002-7863. PMID 12452714.
  20. ^ Blixt, Ola; Head, Steve; Mondala, Tony; Scanlan, Christopher; Huflejt, Margaret E.; Alvarez, Richard; Bryan, Marian C.; Fazio, Fabio; Calarese, Daniel; Stevens, James; Razi, Nahid (2004-12-07). "Printed covalent glycan array for ligand profiling of diverse glycan binding proteins". Proceedings of the National Academy of Sciences. 101 (49): 17033–17038. Bibcode:2004PNAS..10117033B. doi:10.1073/pnas.0407902101. ISSN 0027-8424. PMC 534418. PMID 15563589.
  21. ^ Walker, Laura M.; Huber, Michael; Doores, Katie J.; Falkowska, Emilia; Pejchal, Robert; Julien, Jean-Philippe; Wang, Sheng-Kai; Ramos, Alejandra; Chan-Hui, Po-Ying; Moyle, Matthew; Mitcham, Jennifer L. (2011). "Broad neutralization coverage of HIV by multiple highly potent antibodies". Nature. 477 (7365): 466–470. Bibcode:2011Natur.477..466W. doi:10.1038/nature10373. ISSN 1476-4687. PMC 3393110. PMID 21849977.
  22. ^ Pejchal, R.; Doores, K. J.; Walker, L. M.; Khayat, R.; Huang, P.-S.; Wang, S.-K.; Stanfield, R. L.; Julien, J.-P.; Ramos, A.; Crispin, M.; Depetris, R. (2011-11-25). "A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield". Science. 334 (6059): 1097–1103. Bibcode:2011Sci...334.1097P. doi:10.1126/science.1213256. ISSN 0036-8075. PMC 3280215. PMID 21998254.
  23. ^ Shivatare, Sachin S.; Chang, Shih-Huang; Tsai, Tsung-I.; Tseng, Susan Yu; Shivatare, Vidya S.; Lin, Yih-Shyan; Cheng, Yang-Yu; Ren, Chien-Tai; Lee, Chang-Chun David; Pawar, Sujeet; Tsai, Charng-Sheng (2016). "Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies". Nature Chemistry. 8 (4): 338–346. Bibcode:2016NatCh...8..338S. doi:10.1038/nchem.2463. ISSN 1755-4330. PMC 4806563. PMID 27001729.
  24. ^ Stewart-Jones, Guillaume B.E.; Soto, Cinque; Lemmin, Thomas; Chuang, Gwo-Yu; Druz, Aliaksandr; Kong, Rui; Thomas, Paul V.; Wagh, Kshitij; Zhou, Tongqing; Behrens, Anna-Janina; Bylund, Tatsiana (2016). "Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G". Cell. 165 (4): 813–826. doi:10.1016/j.cell.2016.04.010. PMC 5543418. PMID 27114034.
  25. ^ Shivatare, Vidya S.; Shivatare, Sachin S.; Lee, Chang-Chun David; Liang, Chi-Hui; Liao, Kuo-Shiang; Cheng, Yang-Yu; Saidachary, Gannerla; Wu, Chung-Yi; Lin, Nan-Horng; Kwong, Peter D.; Burton, Dennis R. (2018-04-18). "Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies". Journal of the American Chemical Society. 140 (15): 5202–5210. doi:10.1021/jacs.8b00896. ISSN 0002-7863. PMID 29578688.
  26. ^ Sawa, M.; Hsu, T.-L.; Itoh, T.; Sugiyama, M.; Hanson, S. R.; Vogt, P. K.; Wong, C.-H. (2006-08-15). "Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo". Proceedings of the National Academy of Sciences. 103 (33): 12371–12376. Bibcode:2006PNAS..10312371S. doi:10.1073/pnas.0605418103. ISSN 0027-8424. PMC 1567886. PMID 16895981.
  27. ^ Hsu, Tsui-Ling; Hanson, Sarah R.; Kishikawa, Kuniyuki; Wang, Sheng-Kai; Sawa, Masaaki; Wong, Chi-Huey (2007-02-20). "Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells". Proceedings of the National Academy of Sciences. 104 (8): 2614–2619. Bibcode:2007PNAS..104.2614H. doi:10.1073/pnas.0611307104. ISSN 0027-8424. PMC 1815231. PMID 17296930.
  28. ^ Shie, Jiun-Jie; Liu, Ying-Chih; Lee, Yu-Ming; Lim, Carmay; Fang, Jim-Min; Wong, Chi-Huey (2014-07-16). "An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence upon Triazole Formation". Journal of the American Chemical Society. 136 (28): 9953–9961. doi:10.1021/ja5010174. ISSN 0002-7863. PMID 24955871.
  29. ^ Hanson, S. R.; Culyba, E. K.; Hsu, T.-L.; Wong, C.-H.; Kelly, J. W.; Powers, E. T. (2009-03-03). "The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability". Proceedings of the National Academy of Sciences. 106 (9): 3131–3136. Bibcode:2009PNAS..106.3131H. doi:10.1073/pnas.0810318105. ISSN 0027-8424. PMC 2651298. PMID 19204290.
  30. ^ Huang, Yen-Wen; Yang, Hwai-I; Wu, Ying-Ta; Hsu, Tsui-Ling; Lin, Tzu-Wen; Kelly, Jeffery W.; Wong, Chi-Huey (2017-09-20). "Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency". Journal of the American Chemical Society. 139 (37): 12947–12955. doi:10.1021/jacs.7b03868. ISSN 0002-7863. PMID 28820257.
  31. ^ Krasnova, Larissa; Wong, Chi-Huey (2016-06-02). "Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis". Annual Review of Biochemistry. 85 (1): 599–630. doi:10.1146/annurev-biochem-060614-034420. ISSN 0066-4154. PMID 27145845.
  32. ^ Krasnova, Larissa; Wong, Chi-Huey (2019-03-06). "Oligosaccharide Synthesis and Translational Innovation". Journal of the American Chemical Society. 141 (9): 3735–3754. doi:10.1021/jacs.8b11005. ISSN 0002-7863. PMC 6538563. PMID 30716271.
  33. ^ Chuang, Po-Kai; Hsiao, Michael; Hsu, Tsui-Ling; Chang, Chuan-Fa; Wu, Chung-Yi; Chen, Bo-Rui; Huang, Han-Wen; Liao, Kuo-Shiang; Chen, Chen-Chun; Chen, Chi-Long; Yang, Shun-Min (2019-02-26). "Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer". Proceedings of the National Academy of Sciences. 116 (9): 3518–3523. Bibcode:2019PNAS..116.3518C. doi:10.1073/pnas.1816946116. ISSN 0027-8424. PMC 6397564. PMID 30808745.
  34. ^ Huang, Han-Yi; Liao, Hsin-Yu; Chen, Xiaorui; Wang, Szu-Wen; Wu, Chung-Yi; Jan, Jia-Tsrong; Cheng, Ting-Jen Rachel; Lin, Kuo-I; Ma, Che; Wong, Chi-Huey; et al. (2022-04-06). "Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models". Science Translational Medicine. 14 (639): eabm0899. doi:10.1126/scitranslmed.abm0899. PMC 9802656. PMID 35230146. S2CID 247168008.
  35. ^ Tseng, Yung-Chieh; Wu, Chia-Yu; Liu, Ming-Liang; Chen, Ting-Hua; Chiang, Wan-Ling; Yu, Yueh-Hsiang; Jan, Jia-Tsrong; Lin, Kuo-I; Wong, Chi-Huey; Ma, Che (2019-03-05). "Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections". Proceedings of the National Academy of Sciences. 116 (10): 4200–4205. Bibcode:2019PNAS..116.4200T. doi:10.1073/pnas.1819197116. ISSN 0027-8424. PMC 6410868. PMID 30782805.
  36. ^ Lin, Chin-Wei; Tsai, Ming-Hung; Li, Shiou-Ting; Tsai, Tsung-I.; Chu, Kuo-Ching; Liu, Ying-Chih; Lai, Meng-Yu; Wu, Chia-Yu; Tseng, Yung-Chieh; Shivatare, Sachin S.; Wang, Chia-Hung (2015-08-25). "A common glycan structure on immunoglobulin G for enhancement of effector functions". Proceedings of the National Academy of Sciences of the United States of America. 112 (34): 10611–10616. Bibcode:2015PNAS..11210611L. doi:10.1073/pnas.1513456112. ISSN 1091-6490. PMC 4553773. PMID 26253764.
  37. ^ Lo, Hong-Jay; Krasnova, Larissa; Dey, Supriya; Cheng, Ting; Liu, Haitian; Tsai, Tsung-I; Wu, Kevin Binchia; Wu, Chung-Yi; Wong, Chi-Huey (2019-04-24). "Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing α2,6-Linked 3Fax-Neu5Ac". Journal of the American Chemical Society. 141 (16): 6484–6488. doi:10.1021/jacs.9b01991. ISSN 0002-7863. PMID 30969765. S2CID 108292858.
  38. ^ Lin, Chih-Wei; Wang, Yu-Jen; Lai, Ting-Yen; Hsu, Tsui-Ling; Han, Shin-Ying; Han-Chung, Wu; Shen, Chia-Ning Shen; Chen, Ming-Wei; Chen, Lan-Bo; Wong, Chi-Huey; et al. (2021-12-14). "Homogeneous antibody and CAR-T cells with improved effector functions targeting SSEA-4 glycan on pancreatic cancer". Proceedings of the National Academy of Sciences. 118 (50): e2114774118. Bibcode:2021PNAS..11814774L. doi:10.1073/pnas.2114774118. PMC 8685897. PMID 34876527.
  39. ^ Loa, Lok-sin (31 March 2016). "Wong Chi-huey offers resignation". Taipei Times. Retrieved 25 April 2016.
  40. ^ Normile, Dennis (11 May 2016). "Head of Taiwan's Academia Sinica resigns". Science Magazine. Retrieved 21 February 2018.
  41. ^ Kao, Evelyn; Hsiao, Po-wen (21 February 2018). "Insider trading charges dropped against ex-Academia Sinica head". Central News Agency. Retrieved 22 February 2018.
  42. ^ Lin, Liang-sheng; Chung, Jake (12 April 2022). "Wong Chi-huey deserves retrial, Control Yuan says". Taipei Times. Retrieved 12 April 2022.
  43. ^ "Cotten Medal".
  44. ^ "Academia Sinica President Chi-Huey Wong To Receive 2012 Arthur C. Cope Award". Asian Scientist Magazine. 2011-09-08. Retrieved 2019-10-23.
  45. ^ Wolf Prize in Chemistry 2014
  46. ^ "Academia Sinica President Chi-Huey Wong Receives 2015 Robert Robinson Award". www.genomics.sinica.edu.tw. Archived from the original on 2015-05-12. Retrieved 2019-10-23.
  47. ^ Welch Award in Chemistry 2021
  48. ^ Wu, Hsin-yun; Shih, Hsiu-chuan (12 April 2022). "Taiwanese biochemist Wong Chi-huey receives Chemical Pioneer Award". Central News Agency. Retrieved 13 April 2022. Republished as: "Biochemist receives US 'Pioneer' award". Taipei Times. 13 April 2022. Retrieved 13 April 2022.
  49. ^ "EMBO recognizes 63 researchers for advances in life sciences". EMBO. Archived from the original on 2019-05-13. Retrieved 2019-10-23.
  50. ^ [1], "Crystal structure of bifunctional transglycosylase PBP1b from E. coli and inhibitors thereof", issued 2015-12-04 
  51. ^ "Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants – Dimensions". app.dimensions.ai. Retrieved 2019-10-23.
  52. ^ [2], "Antibiotic compositions and related screening methods", issued 2009-01-15 
  53. ^ [3], "Hirsutella sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses", issued 2010-03-30 
  54. ^ [4], "Tailored glycoproteomic methods for the sequencing, mapping and identification of cellular glycoproteins", issued 2008-03-24 
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