CR6261: Difference between revisions

CR6261
Monoclonal antibody
Type	?
Source	Human
Target	Influenza A hemagglutinin
Clinical data
Pregnancy; category	N/A;
ATC code	none;
Legal status
Legal status	Investigational (animal studies);
Identifiers
PubChem SID	194161622;
ChemSpider	none;
ChEMBL	ChEMBL3137350;
	(what is this?) (verify)

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CR6261 is a monoclonal antibody^[1] that binds to a broad range of the influenza virus including the 1918 "Spanish flu" (SC1918/H1) and to a virus of the H5N1 class of avian influenza that jumped from chickens to a human in Vietnam in 2004 (Viet04/H5). In contrast to most antibodies generated by exposure to influenza, which can only neutralize a few strains from within a single virus subtype, CR6261 neutralizes numerous strains from multiple subtypes. CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of hemagglutinin, the predominant protein on the surface of the influenza virus. Based upon the conservation of the amino acid sequence on this part of hemagglutinin, CR6261 is predicted to neutralize roughly 50% of all flu viruses. It was found by The Scripps Research Institute and the Dutch biopharmaceutical company, Crucell.

References

^ Friesen RH, Koudstaal W, Koldijk MH, Weverling GJ, Brakenhoff JP, Lenting PJ, et al. (February 2010). Zhang L (ed.). "New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets". PLOS ONE. 5 (2): e9106. Bibcode:2010PLoSO...5.9106F. doi:10.1371/journal.pone.0009106. PMC 2817000. PMID 20161706.

"Research team finds immune molecule that attacks wide range of flu viruses". physorg.com. 26 February 2009.
"Immune Molecule That Attacks Wide Range Of Flu Viruses Discovered". ScienceDaily. 27 February 2009.
Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA (April 2009). "Antibody recognition of a highly conserved influenza virus epitope". Science. 324 (5924). New York, N.Y.: 246–51. Bibcode:2009Sci...324..246E. doi:10.1126/science.1171491. PMC 2758658. PMID 19251591.

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[1] Friesen RH, Koudstaal W, Koldijk MH, Weverling GJ, Brakenhoff JP, Lenting PJ, et al. (February 2010). Zhang L (ed.). "New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets". PLOS ONE. 5 (2): e9106. Bibcode:2010PLoSO...5.9106F. doi:10.1371/journal.pone.0009106. PMC 2817000. PMID 20161706.

[1]

@@ Line 1: / Line 1: @@
+{{Short description|Monoclonal antibody}}
-{{Orphan|date=March 2009}}
+{{Drugbox
+| Verifiedfields = changed
+| verifiedrevid = 448818654
+<!-- Monoclonal antibody data -->
+| type = mab
+| mab_type =
+| source = u
+| target = [[Hemagglutinin (influenza)|Influenza A hemagglutinin]]
+<!-- Clinical data -->
+| tradename =
+| pregnancy_AU =
+| pregnancy_US =
+| pregnancy_category = N/A
+| legal_AU =
+| legal_CA =
+| legal_UK =
+| legal_US =
+| legal_status = Investigational (animal studies)
+| routes_of_administration =
+<!-- Pharmacokinetic data -->
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!-- Identifiers -->
+| CAS_number =
+| ATC_prefix = none
+| ATC_suffix =
+| PubChemSubstance = 194161622
+| ChEMBL = 3137350
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
+| ChemSpiderID = none
+<!-- Chemical data -->
+| chemical_formula =
+| molecular_weight =
+}}
+'''CR6261''' is a [[monoclonal antibody]]<ref>{{cite journal | vauthors = Friesen RH, Koudstaal W, Koldijk MH, Weverling GJ, Brakenhoff JP, Lenting PJ, Stittelaar KJ, Osterhaus AD, Kompier R, Goudsmit J | display-authors = 6 | title = New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets | journal = PLOS ONE | volume = 5 | issue = 2 | pages = e9106 | date = February 2010 | pmid = 20161706 | pmc = 2817000 | doi = 10.1371/journal.pone.0009106 | bibcode = 2010PLoSO...5.9106F | editor1-last = Zhang | editor1-first = Linqi | doi-access = free }}</ref> that binds to a broad range of the [[influenza virus]] including the 1918 "[[Spanish flu]]" (SC1918/H1) and to a virus of the [[H5N1]] class of avian influenza that jumped from chickens to a human in Vietnam in 2004 (Viet04/H5). In contrast to most antibodies generated by exposure to influenza, which can only neutralize a few strains from within a single virus subtype, CR6261 neutralizes numerous strains from multiple subtypes.  CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of [[Hemagglutinin (influenza)|hemagglutinin]], the predominant protein on the surface of the [[influenza virus]].  Based upon the conservation of the amino acid sequence on this part of hemagglutinin, CR6261 is predicted to neutralize roughly 50% of all flu viruses.  It was found by [[The Scripps Research Institute]] and the Dutch biopharmaceutical company, [[Crucell]].
+== See also ==
-'''CR6261''' is an [[antibody]] recently discovered to bind to a broad range of the [[influenza virus]] including the 1918 "[[Spanish flu]]" and to a virus of the [[H5N1]] class of avian influenza that jumped from chickens to a human in Vietnam in 2004. CR6261 recognizes a highly conserved helical region in the membrane-[[proximal stem]] of [[HA1/HA2]].  It was found by [[The Scripps Research Institute]].
-==See also==
 * [[Immunology]]
-==External links==
+== References ==
+{{reflist}}
+== Further reading ==
-*Research team finds immune molecule that attacks wide range of flu viruses[http://www.physorg.com/news154880861.html]
+{{refbegin}}
-*Immune Molecule That Attacks Wide Range Of Flu Viruses Discovered[http://www.sciencedaily.com/releases/2009/02/090226141118.htm]
+* {{cite web | title = Research team finds immune molecule that attacks wide range of flu viruses | url = http://www.physorg.com/news154880861.html | work = physorg.com | date = 26 February 2009 }}
-*Antibody Recognition of a Highly Conserved Influenza Virus Epitope[http://www.sciencemag.org/cgi/content/abstract/sci;1171491v1?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexacttitleabs=and&fulltext=CR6261&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT]
+* {{cite web | title = Immune Molecule That Attacks Wide Range Of Flu Viruses Discovered | url = https://www.sciencedaily.com/releases/2009/02/090226141118.htm | work = ScienceDaily | date = 27 February 2009}}
+* {{cite journal | vauthors = Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA | title = Antibody recognition of a highly conserved influenza virus epitope | journal = Science | location = New York, N.Y. | volume = 324 | issue = 5924 | pages = 246–51 | date = April 2009 | pmid = 19251591 | pmc = 2758658 | doi = 10.1126/science.1171491 | bibcode = 2009Sci...324..246E }}
+{{refend}}
-{{med-stub}}
 [[Category:Antibodies]]
-[[Category:Immunology]]
+[[Category:Unnamed monoclonal antibodies]]
+{{monoclonal-antibody-stub}}
+{{antiinfective-drug-stub}}