Brigitte Askonas: Difference between revisions
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{{Short description|British immunologist (1923–2013)}} |
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{{Use dmy dates|date=January 2020}} |
{{Use dmy dates|date=January 2020}} |
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{{Infobox scientist |
{{Infobox scientist |
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| name = Brigitte Askonas |
| name = Brigitte Askonas |
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| honorific_suffix = {{post-nominals|country=GBR|FRS|FMedSci|size=100%}} |
| honorific_suffix = {{post-nominals|country=GBR|FRS|FMedSci|size=100%}} |
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| image = |
| image = Brigitte_Askonas.jpg |
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| alt = |
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| caption = |
| caption = |
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| birth_name = Brigitte Alice Askonas |
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| birth_date = {{Birth date|1923|04|01|df=yes}} |
| birth_date = {{Birth date|1923|04|01|df=yes}} |
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| birth_place = [[Vienna, Austria]] |
| birth_place = [[Vienna, Austria]] |
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| death_date = {{Death date and age|2013|01|09|1923|04|01|df=yes}} |
| death_date = {{Death date and age|2013|01|09|1923|04|01|df=yes}} |
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| death_place = |
| death_place = |
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| workplaces = [[John Radcliffe Hospital]]<br>[[University of Cambridge]]<br>[[Harvard Medical School]]<ref name=whoswho/><br>[[Imperial College London]]<br>[[McGill University]]<br>[[National Institute for Medical Research]] |
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| workplaces = [[John Radcliffe Hospital]]<br/>[[University of Cambridge]]<br/>[[Harvard Medical School]]<ref name=whoswho/><br/>[[Imperial College London]]<br/>[[McGill University]]<br/>[[National Institute for Medical Research]] |
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| alma_mater = [[McGill University]] (BSc, MSc)<br/>[[University of Cambridge]] (PhD) <!--Girton College, Cambridge does NOT award degrees--> |
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| thesis_title = The separation of enzymes by means of organic solvents at low temperatures: application to aqueous rabbit-muscle extract with a study of creatine-phosphokinase |
| thesis_title = The separation of enzymes by means of organic solvents at low temperatures: application to aqueous rabbit-muscle extract with a study of creatine-phosphokinase |
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| thesis_url = https://search.proquest.com/docview/301230275 |
| thesis_url = https://search.proquest.com/docview/301230275 |
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| thesis_year = 1952 |
| thesis_year = 1952 |
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| doctoral_students = [[Andrew McMichael]]<ref name=rsbm/><br>[[Alain Townsend]]<ref name=tphd>{{cite thesis|degree=PhD|title=Recognition of influenza virus specific cytotoxic T cell clones|year=1984|publisher=University of London|url=https://catalogue.libraries.london.ac.uk/record=b1528298|website=london.ac.uk|first=Alain Robert Michael|last=Townsend|id={{copac| 34553445}}|oclc=941030873}}</ref> |
| doctoral_students = Michael J. Bevan<br/>[[Andrew McMichael]]<ref name=rsbm/><br/>[[Alain Townsend]]<ref name=tphd>{{cite thesis|degree=PhD|title=Recognition of influenza virus specific cytotoxic T cell clones|year=1984|publisher=University of London|url=https://catalogue.libraries.london.ac.uk/record=b1528298|website=london.ac.uk|first=Alain Robert Michael|last=Townsend|id={{copac| 34553445}}|oclc=941030873}}</ref> |
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| doctoral_advisor = [[Malcolm Dixon]]<ref name=aphd/> |
| doctoral_advisor = [[Malcolm Dixon (biochemist)|Malcolm Dixon]]<ref name=aphd/> |
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| awards = [[Robert Koch Prize]] (2007)<br>Member of the |
| awards = [[Robert Koch Prize]] (2007)<br/>[[Member of the National Academy of Sciences]] (2007)<ref name=nas/> |
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}} |
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'''Brigitte Alice Askonas''' {{post-nominals|country=GBR|FRS|FMedSci}} (1 April 1923 – 9 January 2013)<ref name=rsbm>{{cite journal|last1=McMichael|first1=Andrew J.| |
'''Brigitte Alice Askonas''' {{post-nominals|country=GBR|FRS|FMedSci}} (1 April 1923 – 9 January 2013)<ref name=rsbm>{{cite journal|last1=McMichael|first1=Andrew J.|author-link1=Andrew McMichael|last2=Ogilvie|first2=Bridget M.|s2cid=81086759|author-link2=Bridget Ogilvie|title=Brigitte Alice Askonas. 1 April 1923—9 January 2013|journal=[[Biographical Memoirs of Fellows of the Royal Society]]|volume=65|year=2018|pages=31–45|issn=0080-4606|doi=10.1098/rsbm.2018.0007|doi-access=free}}</ref> was a British [[immunologist]]<ref>{{cite web|url=http://royalsociety.org/about-us/fellowship/fellows|title=Lists of Royal Society Fellows 1660–2007|publisher=The Royal Society|access-date=6 July 2012|location=London, UK}}</ref> and a visiting professor at [[Imperial College London]] from 1995.<ref name=whoswho>{{Who's Who | author=Anon| title=Askonas, Brigitte Alice (Ita) | id = U5882 | year = 2013 | doi = 10.1093/ww/9780199540884.013.U5882| edition = online [[Oxford University Press]]|type = was|location=Oxford}}</ref><ref>{{cite web|url=http://www.imperial.ac.uk/college.asp?P=2223|title=Imperial College London - 2000 Fellows of Imperial College|access-date=16 March 2016}}</ref><ref name="Nature Obituary">{{cite journal|last=O'Garra|first=Anne|author-link=Anne O'Garra|title=Brigitte Askonas (1923–2013)|journal=Nature|date= 2013|volume=494|issue=7435|pages=37|doi=10.1038/494037a|pmid=23389536|bibcode=2013Natur.494...37O|doi-access=free}}</ref> |
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==Education== |
==Education== |
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Brigitte Askonas was born to Czechoslovak parents, Jewish converts to Catholicism, who fled Austria after the Nazi takeover. |
Brigitte Askonas was born to Czechoslovak parents, Jewish converts to Catholicism, who fled Austria after the Nazi takeover. |
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[[Vienna]]-born Askonas studied biochemistry at [[McGill University]] (BSc, MSc) and carried out her postgraduate work in the school of biochemistry at the [[University of Cambridge]] where she was a student of [[Girton College, Cambridge]].<ref name=aphd>{{cite thesis|degree=PhD|first=Brigitte|last=Askonas|title=The separation of enzymes by means of organic solvents at low temperatures: application to aqueous rabbit-muscle extract with a study of creatine-phosphokinase|publisher=University of Cambridge|date=1952| |
[[Vienna]]-born Askonas studied biochemistry at [[McGill University]] (BSc, MSc) and carried out her postgraduate work in the school of biochemistry at the [[University of Cambridge]] where she was a student of [[Girton College, Cambridge]].<ref name=aphd>{{cite thesis|degree=PhD|first=Brigitte|last=Askonas|title=The separation of enzymes by means of organic solvents at low temperatures: application to aqueous rabbit-muscle extract with a study of creatine-phosphokinase|publisher=University of Cambridge|date=1952|author-link=Brigitte Askonas|id={{ProQuest|301230275}}}}</ref><ref name="Nature Obituary"/><ref name=":0">{{cite journal|last=Askonas|first=Brigitte Alice|title=From Protein Synthesis to Antibody formation and Cellular Immunity: A Personal View|journal=Annual Review of Immunology|date= 1990|volume=8|issue=1|pages=1–22|doi=10.1146/annurev.iy.08.040190.000245|pmid=2188659|doi-access=free}}</ref><ref name=torygraph>{{cite news|url=https://www.telegraph.co.uk/news/obituaries/medicine-obituaries/9970276/Professor-Brigitte-Askonas.html|title=Professor Brigitte Askonas Obituary|publisher=[[The Daily Telegraph]]|author=Anon|website=telegraph.co.uk|date= 4 April 2013}}</ref><ref name=grauniad>{{cite web|url=https://www.theguardian.com/science/2013/jan/10/brigitte-askonas-obituary|title= Obituary for Brigitte Askonas|date=10 January 2013|first=Bridget |last=Ogilvie|website=[[The Guardian]]}}</ref> |
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Her role models in the department included two distinguished scientists, [[Marjory Stephenson]] and [[Dorothy Needham]], |
Her role models in the department included two distinguished scientists, [[Marjory Stephenson]] and [[Dorothy Needham]],<ref name="rsbm" /> two of the first women to be elected to the Royal Society. She said they taught her that "good science gets recognition regardless of the sex of the scientist". Her [[PhD]] research was supervised by [[Malcolm Dixon (biochemist)|Malcolm Dixon]].<ref name=rsbm/><ref name=aphd/><ref name=":0"/> |
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==Career and research== |
==Career and research== |
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Her first position was at the Allan Memorial Institute of Psychiatry (associated with McGill University).<ref name=":0"/> In 1952, she joined the staff of the [[National Institute for Medical Research]] (NIMR) where she served as head of the division of Immunology from 1976 to 1988.<ref name=imm>{{Cite journal|last1=Askonas|first1=B.A.| |
Her first position was at the Allan Memorial Institute of Psychiatry (associated with McGill University).<ref name=":0"/> In 1952, she joined the staff of the [[National Institute for Medical Research]] (NIMR) where she served as head of the division of Immunology from 1976 to 1988.<ref name=imm>{{Cite journal|last1=Askonas|first1=B.A.|author-link=Brigitte Askonas|last2=Rhodes|first2=J.M.|s2cid=27657849|doi=10.1038/205470a0|pmid=14269699|title=Immunogenicity of Antigen-Containing Ribonucleic Acid Preparations from Macrophages|journal=Nature|volume=205|issue=4970|pages=470–4|year=1965|bibcode=1965Natur.205..470A}}</ref><ref>{{Cite journal|last1=McMichael|first1=A.J.|last2=Ting|first2=A.|last3=Zweerink|first3=H.J.|last4=Askonas|first4=B.A.|s2cid=4173925|author-link4=Brigitte Askonas|title=HLA restriction of cell-mediated lysis of influenza virus-infected human cells|doi=10.1038/270524a0|journal=Nature|volume=270|issue=5637|pages=524–26|year=1977|pmid=593371|bibcode=1977Natur.270..524M}}</ref> |
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During that time, she worked extensively with fellow immunologist [[John H. Humphrey]] to establish the immunology divisions. Askonas focused on [[B cells]] and determined their role in producing antibodies as part of the immune response. |
During that time, she worked extensively with fellow immunologist [[John H. Humphrey]] to establish the immunology divisions. Askonas focused on [[B cells]] and determined their role in producing antibodies as part of the immune response. |
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At the NIMR she began researching the [[biosynthesis]] of [[polypeptide]]s in milk [[protein]]s discovering that the [[peptide]]s were synthesised from [[amino acids]] rapidly in one piece.<ref name=":0"/> From 1955-59 she studied the sites of [[antibody]] formation using radioactivity to develop our understanding of [[antibody]] molecules and the cells of the [[immune system]]. From 1959-61 she studied [[plasma cell]] tumors as models for antibody formation. She went on to investigate [[macrophages]] and their role in [[antigen]] presentation (1962–1968). From 1963 to 1966 she studied the fate of [[antigen]] in relation to [[antibody]] formation and later continued her study of [[B cells]] from 1965 to 1970.<ref name=":0"/> |
At the NIMR she began researching the [[biosynthesis]] of [[polypeptide]]s in milk [[protein]]s discovering that the [[peptide]]s were synthesised from [[amino acids]] rapidly in one piece.<ref name=":0"/> From 1955-59 she studied the sites of [[antibody]] formation using radioactivity to develop our understanding of [[antibody]] molecules and the cells of the [[immune system]]. From 1959-61 she studied [[plasma cell]] tumors as models for antibody formation. She went on to investigate [[macrophages]] and their role in [[antigen]] presentation (1962–1968). From 1963 to 1966 she studied the fate of [[antigen]] in relation to [[antibody]] formation and later continued her study of [[B cells]] from 1965 to 1970.<ref name=":0"/> |
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She wrote several biographies of high-profile scientists, including [[Niels Kaj Jerne]],<ref>{{Cite journal | last1 = Askonas | first1 = B. A. | |
She wrote several biographies of high-profile scientists, including [[Niels Kaj Jerne]],<ref>{{Cite journal | last1 = Askonas | first1 = B. A. | author-link1 = Brigitte Askonas| last2 = Howard | first2 = J. G. | s2cid = 45810507 | doi = 10.1098/rsbm.1997.0013 | title = Niels Kaj Jerne. 23 December 1911--7 October 1994.: Elected F.R.S 1980 | journal = [[Biographical Memoirs of Fellows of the Royal Society]] | volume = 43 | pages = 237–251 | year = 1997 | title-link = Niels Kaj Jerne }}</ref> [[César Milstein]]<ref>{{Cite journal | last1 = Neuberger | first1 = M. S. | author-link1 = Michael Neuberger| last2 = Askonas | first2 = B. A. | author-link2 = Brigitte Askonas| doi = 10.1098/rsbm.2005.0017 | title = Cesar Milstein CH. 8 October 1927 - 24 March 2002: Elected F.R.S. 1974 | journal = [[Biographical Memoirs of Fellows of the Royal Society]] | volume = 51 | page = 267 | year = 2005 | title-link = César Milstein | doi-access = free }}</ref> and [[John Herbert Humphrey]].<ref>{{Cite journal|last1=Askonas|first1=B.A.|author-link=Brigitte Askonas|doi=10.1098/rsbm.1990.0033|title=John Herbert Humphrey. 16 December 1915-25 December 1987|journal=[[Biographical Memoirs of Fellows of the Royal Society]]|volume=36|year=1990|pages=274–300|title-link=John H. Humphrey|pmid=11616175|doi-access=free}}</ref> Askonas conducted a [https://doi.org/10.24384/000234/ filmed interview] with [[Stanley Peart]] as a segment of what became the Medical Sciences Video Archive<ref>{{cite web|url=https://www.brookes.ac.uk/library/collections/special-collections/public-and-allied-health/medical-sciences-video-archive/|title=Medical Sciences Video Archive}}</ref> housed in the special collections of the library at [[Oxford Brookes University]]. |
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===Awards and honours=== |
===Awards and honours=== |
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In 2007 she was made a foreign associate of the [[National Academy of Sciences]] of the [[United States]]<ref name=nas>{{cite web|url=http://www.nasonline.org/member-directory/deceased-members/20015153.html|title=Brigitte Askonas |
In 2007 she was made a foreign associate of the [[National Academy of Sciences]] of the [[United States]]<ref name=nas>{{cite web|url=http://www.nasonline.org/member-directory/deceased-members/20015153.html|title=Brigitte Askonas|website=www.nasonline.org}}</ref><ref>{{cite web|url=http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=05012007|website=nationalacademies.org|title=72 new members chosen by the Academy|author=Anon|year=2007|access-date=16 March 2016}}</ref> and won the [[Robert Koch Prize]].<ref name=rsbm/> She was also elected a [[Fellow of the Royal Society]] (FRS) in 1973<ref name=rsbm/> and a [[Fellow of the Academy of Medical Sciences]] (FMedSci).{{when|date=August 2018}} |
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==References== |
==References== |
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[[Category:2013 deaths]] |
[[Category:2013 deaths]] |
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[[Category:Alumni of Girton College, Cambridge]] |
[[Category:Alumni of Girton College, Cambridge]] |
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[[Category:Austrian emigrants to |
[[Category:Austrian emigrants to the United Kingdom]] |
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[[Category:British immunologists]] |
[[Category:British immunologists]] |
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[[Category: |
[[Category:Female fellows of the Royal Society]] |
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[[Category: |
[[Category:Fellows of the Academy of Medical Sciences (United Kingdom)]] |
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[[Category:Fellows of the Academy of Medical Sciences]] |
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[[Category:Fellows of Girton College, Cambridge]] |
[[Category:Fellows of Girton College, Cambridge]] |
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[[Category:Foreign associates of the National Academy of Sciences]] |
[[Category:Foreign associates of the National Academy of Sciences]] |
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[[Category:McGill University alumni]] |
[[Category:McGill University Faculty of Science alumni]] |
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[[Category:National Institute for Medical Research faculty]] |
[[Category:National Institute for Medical Research faculty]] |
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[[Category:Place of death missing]] |
[[Category:Place of death missing]] |
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[[Category:20th-century American scientists]] |
[[Category:20th-century American scientists]] |
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[[Category:Fellows of the Royal Society]] |
[[Category:Fellows of the Royal Society]] |
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[[Category:21st-century American women]] |
Revision as of 08:25, 13 September 2024
Brigitte Askonas | |
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Born | Brigitte Alice Askonas 1 April 1923 |
Died | 9 January 2013 | (aged 89)
Alma mater | McGill University (BSc, MSc) University of Cambridge (PhD) |
Awards | Robert Koch Prize (2007) Member of the National Academy of Sciences (2007)[1] |
Scientific career | |
Institutions | John Radcliffe Hospital University of Cambridge Harvard Medical School[2] Imperial College London McGill University National Institute for Medical Research |
Thesis | The separation of enzymes by means of organic solvents at low temperatures: application to aqueous rabbit-muscle extract with a study of creatine-phosphokinase (1952) |
Doctoral advisor | Malcolm Dixon[3] |
Doctoral students | Michael J. Bevan Andrew McMichael[4] Alain Townsend[5] |
Brigitte Alice Askonas FRS FMedSci (1 April 1923 – 9 January 2013)[4] was a British immunologist[6] and a visiting professor at Imperial College London from 1995.[2][7][8]
Education
Brigitte Askonas was born to Czechoslovak parents, Jewish converts to Catholicism, who fled Austria after the Nazi takeover. Vienna-born Askonas studied biochemistry at McGill University (BSc, MSc) and carried out her postgraduate work in the school of biochemistry at the University of Cambridge where she was a student of Girton College, Cambridge.[3][8][9][10][11]
Her role models in the department included two distinguished scientists, Marjory Stephenson and Dorothy Needham,[4] two of the first women to be elected to the Royal Society. She said they taught her that "good science gets recognition regardless of the sex of the scientist". Her PhD research was supervised by Malcolm Dixon.[4][3][9]
Career and research
Her first position was at the Allan Memorial Institute of Psychiatry (associated with McGill University).[9] In 1952, she joined the staff of the National Institute for Medical Research (NIMR) where she served as head of the division of Immunology from 1976 to 1988.[12][13]
During that time, she worked extensively with fellow immunologist John H. Humphrey to establish the immunology divisions. Askonas focused on B cells and determined their role in producing antibodies as part of the immune response.
At the NIMR she began researching the biosynthesis of polypeptides in milk proteins discovering that the peptides were synthesised from amino acids rapidly in one piece.[9] From 1955-59 she studied the sites of antibody formation using radioactivity to develop our understanding of antibody molecules and the cells of the immune system. From 1959-61 she studied plasma cell tumors as models for antibody formation. She went on to investigate macrophages and their role in antigen presentation (1962–1968). From 1963 to 1966 she studied the fate of antigen in relation to antibody formation and later continued her study of B cells from 1965 to 1970.[9]
She wrote several biographies of high-profile scientists, including Niels Kaj Jerne,[14] César Milstein[15] and John Herbert Humphrey.[16] Askonas conducted a filmed interview with Stanley Peart as a segment of what became the Medical Sciences Video Archive[17] housed in the special collections of the library at Oxford Brookes University.
Awards and honours
In 2007 she was made a foreign associate of the National Academy of Sciences of the United States[1][18] and won the Robert Koch Prize.[4] She was also elected a Fellow of the Royal Society (FRS) in 1973[4] and a Fellow of the Academy of Medical Sciences (FMedSci).[when?]
References
- ^ a b "Brigitte Askonas". www.nasonline.org.
- ^ a b Anon (2013). "Askonas, Brigitte Alice (Ita)". Who's Who & Who Was Who (online Oxford University Press ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U5882. (Subscription or UK public library membership required.)
- ^ a b c Askonas, Brigitte (1952). The separation of enzymes by means of organic solvents at low temperatures: application to aqueous rabbit-muscle extract with a study of creatine-phosphokinase (PhD thesis). University of Cambridge. ProQuest 301230275.
- ^ a b c d e f McMichael, Andrew J.; Ogilvie, Bridget M. (2018). "Brigitte Alice Askonas. 1 April 1923—9 January 2013". Biographical Memoirs of Fellows of the Royal Society. 65: 31–45. doi:10.1098/rsbm.2018.0007. ISSN 0080-4606. S2CID 81086759.
- ^ Townsend, Alain Robert Michael (1984). Recognition of influenza virus specific cytotoxic T cell clones. london.ac.uk (PhD thesis). University of London. OCLC 941030873. Copac 34553445.
- ^ "Lists of Royal Society Fellows 1660–2007". London, UK: The Royal Society. Retrieved 6 July 2012.
- ^ "Imperial College London - 2000 Fellows of Imperial College". Retrieved 16 March 2016.
- ^ a b O'Garra, Anne (2013). "Brigitte Askonas (1923–2013)". Nature. 494 (7435): 37. Bibcode:2013Natur.494...37O. doi:10.1038/494037a. PMID 23389536.
- ^ a b c d e Askonas, Brigitte Alice (1990). "From Protein Synthesis to Antibody formation and Cellular Immunity: A Personal View". Annual Review of Immunology. 8 (1): 1–22. doi:10.1146/annurev.iy.08.040190.000245. PMID 2188659.
- ^ Anon (4 April 2013). "Professor Brigitte Askonas Obituary". telegraph.co.uk. The Daily Telegraph.
- ^ Ogilvie, Bridget (10 January 2013). "Obituary for Brigitte Askonas". The Guardian.
- ^ Askonas, B.A.; Rhodes, J.M. (1965). "Immunogenicity of Antigen-Containing Ribonucleic Acid Preparations from Macrophages". Nature. 205 (4970): 470–4. Bibcode:1965Natur.205..470A. doi:10.1038/205470a0. PMID 14269699. S2CID 27657849.
- ^ McMichael, A.J.; Ting, A.; Zweerink, H.J.; Askonas, B.A. (1977). "HLA restriction of cell-mediated lysis of influenza virus-infected human cells". Nature. 270 (5637): 524–26. Bibcode:1977Natur.270..524M. doi:10.1038/270524a0. PMID 593371. S2CID 4173925.
- ^ Askonas, B. A.; Howard, J. G. (1997). "Niels Kaj Jerne. 23 December 1911--7 October 1994.: Elected F.R.S 1980". Biographical Memoirs of Fellows of the Royal Society. 43: 237–251. doi:10.1098/rsbm.1997.0013. S2CID 45810507.
- ^ Neuberger, M. S.; Askonas, B. A. (2005). "Cesar Milstein CH. 8 October 1927 - 24 March 2002: Elected F.R.S. 1974". Biographical Memoirs of Fellows of the Royal Society. 51: 267. doi:10.1098/rsbm.2005.0017.
- ^ Askonas, B.A. (1990). "John Herbert Humphrey. 16 December 1915-25 December 1987". Biographical Memoirs of Fellows of the Royal Society. 36: 274–300. doi:10.1098/rsbm.1990.0033. PMID 11616175.
- ^ "Medical Sciences Video Archive".
- ^ Anon (2007). "72 new members chosen by the Academy". nationalacademies.org. Retrieved 16 March 2016.
- 1923 births
- 2013 deaths
- Alumni of Girton College, Cambridge
- Austrian emigrants to the United Kingdom
- British immunologists
- Female fellows of the Royal Society
- Fellows of the Academy of Medical Sciences (United Kingdom)
- Fellows of Girton College, Cambridge
- Foreign associates of the National Academy of Sciences
- McGill University Faculty of Science alumni
- National Institute for Medical Research faculty
- 20th-century American women scientists
- 20th-century American scientists
- Fellows of the Royal Society
- 21st-century American women