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{{Short description|British structural and molecular biologist}}
{{EngvarB|date=July 2017}}
{{Use dmy dates|date=July 2017}}
{{Infobox scientist
{{Infobox scientist
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| caption = Daniela Rhodes at the [[Laboratory of Molecular Biology]]
| caption = Daniela Rhodes at the [[Laboratory of Molecular Biology]]
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| workplaces = {{Plainlist|
* [[Nanyang Technological University]]
* [[Nanyang Technological University]]
* [[Laboratory of Molecular Biology]]<ref name=lmb>{{cite web|archiveurl=https://web.archive.org/web/20151208035604/http://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/daniela-rhodes/|archivedate=2015-12-08|url=http://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/daniela-rhodes/|publisher=Laboratory of Molecular Biology|title=Emeritus Scientist: Daniela Rhodes}}</ref>}}
* [[Laboratory of Molecular Biology]]<ref name=lmb>{{cite web|archive-url=https://archive.today/20151208035604/http://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/daniela-rhodes/|archive-date=8 December 2015|url=http://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/daniela-rhodes/|publisher=Laboratory of Molecular Biology|title=Emeritus Scientist: Daniela Rhodes}}</ref>}}
| patrons =
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| alma_mater = [[University of Cambridge]]
| alma_mater = [[University of Cambridge]]
| thesis_title = The helical periodicity of DNA in solution and in chromatin
| thesis_title = The helical periodicity of DNA in solution and in chromatin
| thesis_url = http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257701
| thesis_url = http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257701
| thesis_year = 1982
| thesis_year = 1982
| doctoral_advisor = [[Aaron Klug]]<ref>[http://www.nature.com/embor/journal/v3/n5/full/embor155.html "Climbing mountains: A profile of Max Perutz"], ''EMBO reports'' 3, 5, 393–395 (2002){{dead}}</ref>
| doctoral_advisor = [[Aaron Klug]]<ref name="Rhodes2002" />
| academic_advisors =
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| notable_students =
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| awards = [[Fellow of the Royal Society|FRS]] (2007)<ref name=frs>{{cite web|archiveurl=https://web.archive.org/web/20151117110822/https://royalsociety.org/people/daniela-rhodes-12168/|archivedate=2015-11-17|url=https://royalsociety.org/people/daniela-rhodes-12168/|publisher=[[Royal Society]]|location=London|title=Professor Daniela Rhodes FRS}}</ref>
| awards = [[Fellow of the Royal Society|FRS]] (2007);<ref name=frs>{{cite web|archive-url=https://web.archive.org/web/20151117110822/https://royalsociety.org/people/daniela-rhodes-12168/|archive-date=17 November 2015|url=https://royalsociety.org/people/daniela-rhodes-12168/|publisher=[[Royal Society]]|location=London|title=Professor Daniela Rhodes FRS}}</ref>
The WLA Prize in Life Science or Medicine (2023)
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| website = {{URL|http://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/daniela-rhodes/}}
| website = {{URL|www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/daniela-rhodes/}}
| footnotes =
| footnotes =
}}
}}

'''Daniela Rhodes''' [[Fellow of the Royal Society|FRS]]<ref name=frs/> is a distinguished structural and molecular biologist. She was a senior scientist at the [[Laboratory of Molecular Biology]] in [[Cambridge]], England,<ref name="set-routes1">{{cite web|url=http://www.set-routes.org/conference/speakers/rhodes.html |title=International Conference - Speakers - Daniela Rhodes |publisher=SET-Routes |date=2008-04-01 |accessdate=2014-01-02}}</ref> where she worked, and later studied for her Ph.D<ref>{{cite thesis|degree=PhD|publisher=University of Cambridge|title=The helical periodicity of DNA in solution and in chromatin.|first= Daniela|last=Rhodes|date=1982|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257701|oclc=556524059}}</ref> under the supervision of Nobel laureate [[Aaron Klug]]. Continuing her work under the tutelage of [[Aaron Klug]] at [[Cambridge]], she was appointed Group Leader in 1983, obtained tenure in 1987 and was promoted to Senior Scientist in 1994 (equivalent to Full Professor). Subsequently, she served as Director of Studies between 2003-2006. She has also been Visiting Professor at both “[[La Sapienza]]” in Rome, Italy and the [[Rockefeller University]] in NY, USA.<ref>[http://books.google.com/books?id=hjO5Uoc7GaYC&pg=PA215&lpg=PA215&dq=Daniela+Rhodes&source=bl&ots=PJDKCUn9II&sig=utoLI_lN_y50_MBE2LcNFjqpFnU&hl=en&ei=p0jgS8DBK4_e9AS5kOXGCQ&sa=X&oi=book_result&ct=result&resnum=3&ved=0CA4Q6AEwAjgK#v=onepage&q=Daniela%20Rhodes&f=false "Analysis of sequence-specific DNA-binging proteins"], ''Protein function: a practical approach'', Editor Thomas E. Creighton, Oxford University Press, 1997, ISBN 978-0-19-963615-0</ref><ref>[http://books.google.com/books?id=tVnxXiIB4CAC&pg=PA191&dq=Daniela+Rhodes&cd=3#v=onepage&q=Daniela%20Rhodes&f=false "The Role of Histone H1 in Chromatin Condensation and Transcriptional Repression"], ''Structural biology and functional genomics'', Editors E. Morton Bradbury, Sándor Pongor, Springer, 1999, ISBN 978-0-7923-5781-0</ref><ref>[http://books.google.com/books?id=beWBOadOf9AC&pg=PA139&dq=Daniela+Rhodes&cd=4#v=onepage&q=Daniela%20Rhodes&f=false "Telomeric DNA Recoginition"], ''RNA biochemistry and biotechnology'', Volume 1998, Editors Jan Barciszewski, Brian Frederic Carl Clark, Springer, 1999, ISBN 978-0-7923-5861-9</ref><ref>"Structure of the 30nm Chromatin Fibre and the Regulation of Its Compaction" {{cite web|url=http://www.med.unc.edu/biochem/events/past-events/seminars/daniela-rhodes-phd |title=Daniela Rhodes, PhD — Biochemistry and Biophysics |publisher=University of North Carolina School of Medicine |date=2008-04-22 |accessdate=2014-01-02}}</ref><ref>[http://en.scientificcommons.org/daniela_rhodes Daniela Rhodes's profile at ''Scientific Commons'']</ref>
'''Daniela Bargellini Rhodes''' [[Fellow of the Royal Society|FRS]]<ref name=frs/> (born 1946) is an Italian structural and molecular biologist. She was a senior scientist at the [[Laboratory of Molecular Biology]] in [[Cambridge]], England,<ref name="set-routes1">{{cite web |url=http://www.set-routes.org/conference/speakers/rhodes.html |title=International Conference – Speakers – Daniela Rhodes |publisher=SET-Routes |date=1 April 2008 |access-date=2 January 2014 |archive-date=3 March 2016 |archive-url=https://web.archive.org/web/20160303174831/http://www.set-routes.org/conference/speakers/rhodes.html |url-status=dead }}</ref> where she worked, and later studied for her PhD<ref>{{cite thesis|degree=PhD|publisher=University of Cambridge|title=The helical periodicity of DNA in solution and in chromatin.|first= Daniela|last=Rhodes|year=1982|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257701|oclc=556524059}}</ref> under the supervision of Nobel laureate [[Aaron Klug]]. Continuing her work under the tutelage of [[Aaron Klug]] at [[Cambridge]], she was appointed group leader in 1983, obtained tenure in 1987 and was promoted to senior scientist in 1994 (equivalent to full professor). Subsequently, she served as director of studies between 2003 and 2006. She has also been visiting professor at both "[[La Sapienza]]" in Rome, Italy and the [[Rockefeller University]] in NY, USA.<ref>[https://books.google.com/books?id=hjO5Uoc7GaYC&dq=Daniela+Rhodes&pg=PA215 "Analysis of sequence-specific DNA-binging proteins"], ''Protein function: a practical approach'', Editor Thomas E. Creighton, Oxford University Press, 1997, {{ISBN|978-0-19-963615-0}}</ref><ref>[https://books.google.com/books?id=tVnxXiIB4CAC&dq=Daniela+Rhodes&pg=PA191 "The Role of Histone H1 in Chromatin Condensation and Transcriptional Repression"], ''Structural biology and functional genomics'', Editors E. Morton Bradbury, Sándor Pongor, Springer, 1999, {{ISBN|978-0-7923-5781-0}}</ref><ref>[https://books.google.com/books?id=beWBOadOf9AC&dq=Daniela+Rhodes&pg=PA139 "Telomeric DNA Recognition"], ''RNA biochemistry and biotechnology'', Volume 1998, Editors Jan Barciszewski, Brian Frederic Carl Clark, Springer, 1999, {{ISBN|978-0-7923-5861-9}}</ref><ref>"Structure of the 30nm Chromatin Fibre and the Regulation of Its Compaction" {{cite web |url=http://www.med.unc.edu/biochem/events/past-events/seminars/daniela-rhodes-phd |title=Daniela Rhodes, PhD – Biochemistry and Biophysics |publisher=University of North Carolina School of Medicine |date=22 April 2008 |access-date=2 January 2014 |archive-url=https://web.archive.org/web/20120926105048/http://www.med.unc.edu/biochem/events/past-events/seminars/daniela-rhodes-phd/ |archive-date=26 September 2012 |url-status=dead }}</ref><ref>[http://en.scientificcommons.org/daniela_rhodes Daniela Rhodes's profile at ''Scientific Commons'']</ref>


==Career and research==
==Career and research==
Daniela Rhodes has made many fundamental contributions to understanding the structure and function of nucleic acids and their biologically important interactions with many different proteins. Her work combines biochemical analyses with direct structural determination. She determined the structures of a number of important protein-DNA complexes involved in transcription, such as [[zinc finger|zinc-fingers]] and nuclear hormone receptors. She has provided some of the first structural information on [[Telomere|telomeric]] proteins, such as yeast [[Rap1p]] and human [[TRF1]] and [[TRF2]] and their complexes with [[DNA]]. Throughout her career she has made many contributions to the understanding of chromatin structure and function. She was involved in determining the structure of the [[nucleosome core particle]], has worked on transcriptionally active [[chromatin]] and more recently on the higher order [[Heterochromatin|30nm structure of chromatin]].<ref name="set-routes1"/> Her research continues to focus on understanding how the structure of [[chromatin]] is involved in [[transcriptional regulation]] and how [[telomeres]] are involved in preserving chromosome integrity.<ref>[http://www2.mrc-lmb.cam.ac.uk/SS/Rhodes_D/ LMB Web-page]</ref>
Daniela Rhodes has made many fundamental contributions to understanding the structure and function of nucleic acids and their biologically important interactions with many different proteins. Her work combines biochemical analyses with direct structural determination. She determined the structures of a number of important protein-DNA complexes involved in transcription, such as [[zinc finger|zinc-fingers]] and nuclear hormone receptors. She has provided some of the first structural information on [[Telomere|telomeric]] proteins, such as yeast Rap1p and human [[TERF1|TRF1]] and [[TRAF2|TRF2]] and their complexes with [[DNA]]. Throughout her career she has made many contributions to the understanding of chromatin structure and function. She was involved in determining the structure of the [[nucleosome core particle]], has worked on transcriptionally active [[chromatin]] and more recently on the higher order [[Heterochromatin|30nm structure of chromatin]].<ref name="set-routes1"/> Her research continues to focus on understanding how the structure of [[chromatin]] is involved in [[transcriptional regulation]] and how [[telomeres]] are involved in preserving chromosome integrity.<ref>[http://www2.mrc-lmb.cam.ac.uk/SS/Rhodes_D/ LMB Web-page] {{webarchive|url=https://web.archive.org/web/20090330131831/http://www2.mrc-lmb.cam.ac.uk/ss/Rhodes_D/ |date=30 March 2009 }}</ref>


She joined the School of Biological Sciences at [[Nanyang Technological University]] (NTU), in Singapore, as professor in September 2011<ref>{{cite web|url=http://research.ntu.edu.sg/expertise/academicprofile/pages/StaffProfile.aspx?ST_EMAILID=DRHODES |title=Academic Profile: Professor Daniela Rhodes |publisher=[[Nanyang Technological University]] |date=2009-08-04 |accessdate=2014-01-02}}</ref> and was additionally appointed professor at the Lee Kong Chian School of Medicine in September 2012.<ref>{{cite web|url=http://www.lkcmedicine.ntu.edu.sg/Research/researchfaculty/Pages/Prof-Daniela-Rhodes.aspx |title=Academic Profile: Professor Daniela Rhodes |publisher=[[LKC School of Medicine]] |date=2009-08-04 |accessdate=2014-04-03}}</ref> In April 2014 she was appointed Director of the newly formed Nanyang Institute of Structural Biology.
She joined the School of Biological Sciences at [[Nanyang Technological University]] (NTU), in Singapore, as professor in September 2011<ref>{{cite web|url=http://research.ntu.edu.sg/expertise/academicprofile/pages/StaffProfile.aspx?ST_EMAILID=DRHODES |title=Academic Profile: Professor Daniela Rhodes |publisher=[[Nanyang Technological University]] |date=4 August 2009 |access-date=2 January 2014}}</ref> and was additionally appointed professor at the Lee Kong Chian School of Medicine in September 2012.<ref>{{cite web|url=http://www.lkcmedicine.ntu.edu.sg/Research/researchfaculty/Pages/Prof-Daniela-Rhodes.aspx |archive-url=https://archive.today/20140403133439/http://www.lkcmedicine.ntu.edu.sg/Research/researchfaculty/Pages/Prof-Daniela-Rhodes.aspx |url-status=dead |archive-date=2014-04-03 |title=Academic Profile: Professor Daniela Rhodes |publisher=[[LKC School of Medicine]] |date=4 August 2009 |access-date=3 April 2014 }}</ref> In April 2014 she was appointed Director of the newly formed Nanyang Institute of Structural Biology.

Daniela left NTU in 2020 and is an Emeritus Scientist at the Laboratory of Molecular Biology.


==Awards and honours==
==Awards and honours==
* Laureate of the 2023 [https://www.thewlaprize.org/ World Laureates Association Prize in Life Science or Medicine] ([[Timothy J. Richmond|With Timothy J. Richmond]] and [[Karolin Luger]])<ref>{{cite web |title=Laureates of the 2023 WLA Prize Announced |url=https://www.thewlaprize.org/PressRoom/News/2023/09/14/179.html |website=The WLA Prize}}</ref>
* Elected a [[List of Fellows of the Royal Society elected in 2007|Fellow of the Royal Society (FRS) in 2007]]<ref name=frs/>
* Elected a [[List of Fellows of the Royal Society elected in 2007|Fellow of the Royal Society (FRS) in 2007]]<ref name=frs/>
* Elected member of [[EMBO]] as of 1996.
* Elected member of [[European Molecular Biology Organization|EMBO]] as of 1996.
* Elected member of [[Academia Europaea]] as of 2011.
* Elected member of [[Academia Europaea]] as of 2011.
* She is a Fellow of [[Clare Hall, Cambridge]].
* She is a Fellow of [[Clare Hall, Cambridge]].
* Asteroid [[80008 Danielarhodes]], discovered by Italian astronomers [[Luciano Tesi]] and [[Andrea Boattini]] in 1999, was named in her honor.<ref name="MPC-object" /> The official {{MoMP|80008|naming citation}} was published by the [[Minor Planet Center]] on 10 December 2011 ({{small|[[Minor Planet Circulars|M.P.C.]] 77507}}).<ref name="MPC-Circulars-Archive" />


==References==
==References==
{{Reflist|35em}}
{{Reflist|35em|refs=


<ref name="Rhodes2002">{{cite journal
|last1=Rhodes|first1=D.
|title=Climbing mountains: A profile of Max Perutz 1914–2002: a life in science
|journal=EMBO Reports
|volume=3
|issue=5
|date=2002
|pages=393–395
|issn=1469-221X
|doi=10.1093/embo-reports/kvf103
|pmc=1084116
|pmid=11991939}}</ref>

<ref name="MPC-object">{{cite web
|title = (80008) Danielarhodes
|work = Minor Planet Center
|url = http://www.minorplanetcenter.net/db_search/show_object?object_id=80008
|access-date = 15 January 2020}}</ref>

<ref name="MPC-Circulars-Archive">{{cite web
|title = MPC/MPO/MPS Archive
|work = Minor Planet Center
|url = https://www.minorplanetcenter.net/iau/ECS/MPCArchive/MPCArchive_TBL.html
|access-date = 15 January 2020}}</ref>



}} <!-- end of reflist-->

{{FRS 2007}}
{{Authority control}}
{{Authority control}}


{{Persondata <!-- Metadata: see [[Wikipedia:Persondata]]. -->
| NAME = Rhodes, Daniela
| ALTERNATIVE NAMES =
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| SHORT DESCRIPTION = British structural and molecular biologist
| DATE OF BIRTH =
| PLACE OF BIRTH =
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| PLACE OF DEATH =
}}
{{DEFAULTSORT:Rhodes, Daniela}}
{{DEFAULTSORT:Rhodes, Daniela}}
[[Category:Female Fellows of the Royal Society]]
[[Category:Female fellows of the Royal Society]]
[[Category:Living people]]
[[Category:Living people]]
[[Category:Place of birth missing (living people)]]
[[Category:Place of birth missing (living people)]]
[[Category:Year of birth missing (living people)]]
[[Category:British women scientists]]
[[Category:British women scientists]]
[[Category:British molecular biologists]]
[[Category:British molecular biologists]]
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[[Category:Nanyang Technological University]]
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[[Category:Fellows of the Royal Society]]
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[[Category:Academic staff of Nanyang Technological University]]
[[Category:1946 births]]

Latest revision as of 08:31, 13 September 2024

Daniela Rhodes
Daniela Rhodes at the Laboratory of Molecular Biology
Alma materUniversity of Cambridge
AwardsFRS (2007);[1] The WLA Prize in Life Science or Medicine (2023)
Scientific career
Institutions
ThesisThe helical periodicity of DNA in solution and in chromatin (1982)
Doctoral advisorAaron Klug[3]
Websitewww2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/daniela-rhodes/

Daniela Bargellini Rhodes FRS[1] (born 1946) is an Italian structural and molecular biologist. She was a senior scientist at the Laboratory of Molecular Biology in Cambridge, England,[4] where she worked, and later studied for her PhD[5] under the supervision of Nobel laureate Aaron Klug. Continuing her work under the tutelage of Aaron Klug at Cambridge, she was appointed group leader in 1983, obtained tenure in 1987 and was promoted to senior scientist in 1994 (equivalent to full professor). Subsequently, she served as director of studies between 2003 and 2006. She has also been visiting professor at both "La Sapienza" in Rome, Italy and the Rockefeller University in NY, USA.[6][7][8][9][10]

Career and research

[edit]

Daniela Rhodes has made many fundamental contributions to understanding the structure and function of nucleic acids and their biologically important interactions with many different proteins. Her work combines biochemical analyses with direct structural determination. She determined the structures of a number of important protein-DNA complexes involved in transcription, such as zinc-fingers and nuclear hormone receptors. She has provided some of the first structural information on telomeric proteins, such as yeast Rap1p and human TRF1 and TRF2 and their complexes with DNA. Throughout her career she has made many contributions to the understanding of chromatin structure and function. She was involved in determining the structure of the nucleosome core particle, has worked on transcriptionally active chromatin and more recently on the higher order 30nm structure of chromatin.[4] Her research continues to focus on understanding how the structure of chromatin is involved in transcriptional regulation and how telomeres are involved in preserving chromosome integrity.[11]

She joined the School of Biological Sciences at Nanyang Technological University (NTU), in Singapore, as professor in September 2011[12] and was additionally appointed professor at the Lee Kong Chian School of Medicine in September 2012.[13] In April 2014 she was appointed Director of the newly formed Nanyang Institute of Structural Biology.

Daniela left NTU in 2020 and is an Emeritus Scientist at the Laboratory of Molecular Biology.

Awards and honours

[edit]

References

[edit]
  1. ^ a b c "Professor Daniela Rhodes FRS". London: Royal Society. Archived from the original on 17 November 2015.
  2. ^ "Emeritus Scientist: Daniela Rhodes". Laboratory of Molecular Biology. Archived from the original on 8 December 2015.
  3. ^ Rhodes, D. (2002). "Climbing mountains: A profile of Max Perutz 1914–2002: a life in science". EMBO Reports. 3 (5): 393–395. doi:10.1093/embo-reports/kvf103. ISSN 1469-221X. PMC 1084116. PMID 11991939.
  4. ^ a b "International Conference – Speakers – Daniela Rhodes". SET-Routes. 1 April 2008. Archived from the original on 3 March 2016. Retrieved 2 January 2014.
  5. ^ Rhodes, Daniela (1982). The helical periodicity of DNA in solution and in chromatin (PhD thesis). University of Cambridge. OCLC 556524059.
  6. ^ "Analysis of sequence-specific DNA-binging proteins", Protein function: a practical approach, Editor Thomas E. Creighton, Oxford University Press, 1997, ISBN 978-0-19-963615-0
  7. ^ "The Role of Histone H1 in Chromatin Condensation and Transcriptional Repression", Structural biology and functional genomics, Editors E. Morton Bradbury, Sándor Pongor, Springer, 1999, ISBN 978-0-7923-5781-0
  8. ^ "Telomeric DNA Recognition", RNA biochemistry and biotechnology, Volume 1998, Editors Jan Barciszewski, Brian Frederic Carl Clark, Springer, 1999, ISBN 978-0-7923-5861-9
  9. ^ "Structure of the 30nm Chromatin Fibre and the Regulation of Its Compaction" "Daniela Rhodes, PhD – Biochemistry and Biophysics". University of North Carolina School of Medicine. 22 April 2008. Archived from the original on 26 September 2012. Retrieved 2 January 2014.
  10. ^ Daniela Rhodes's profile at Scientific Commons
  11. ^ LMB Web-page Archived 30 March 2009 at the Wayback Machine
  12. ^ "Academic Profile: Professor Daniela Rhodes". Nanyang Technological University. 4 August 2009. Retrieved 2 January 2014.
  13. ^ "Academic Profile: Professor Daniela Rhodes". LKC School of Medicine. 4 August 2009. Archived from the original on 3 April 2014. Retrieved 3 April 2014.
  14. ^ "Laureates of the 2023 WLA Prize Announced". The WLA Prize.
  15. ^ "(80008) Danielarhodes". Minor Planet Center. Retrieved 15 January 2020.
  16. ^ "MPC/MPO/MPS Archive". Minor Planet Center. Retrieved 15 January 2020.
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