Greehey Children's Cancer Research Institute: Difference between revisions
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[[File:Greehey Children's Cancer Research Institute, San Antonio, Texas (2 April 2007).jpg|thumb|right|300px|Greehey CCRI is a part of the [[UTHSCSA]].]]Since 2004, '''UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI''') mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of causes of childhood cancer, and accelerate the translation of knowledge into novel therapies. Through discovery, development and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on the problem of childhood cancer. Our mission consists of three key areas — research, clinical and education. |
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[[File:Greehey Children's Cancer Research Institute, San Antonio, Texas (2 April 2007).jpg|thumb|right|300px|Greehey CCRI is a part of the [[UTHSCSA]].]]The '''Greehey Children's Cancer Research Institute''' is a research center in [[San Antonio]], [[Texas]], US. |
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== Research == |
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Strengths include cancer genomics, DNA damage, RNA biology and drug development, developing expertise in drug delivery, with a focus on nanotechnology-driven delivery of small RNA mimics and inhibitors. The Pediatric Translational Working Group formed as part of the Mays Cancer Center P30, meets regularly to coordinate discoveries with application to development of novel therapies. |
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The institute was established in 1999 under a $200,000,000 endowment from the State of Texas tobacco settlement, at the time the largest single oncology endowment in US history. The $50 million facility was completed in 2004. The facility is part of the [[University of Texas Health Science Center at San Antonio]].<ref>{{Cite web|url=https://gccri.uthscsa.edu/|title=Home|website=Greehey Children's Cancer Research Institute}}</ref> |
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== Biostatistics and Bioinformatics == |
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A key objective for the Department of Epidemiology & Biostatistics (DEB) is to provide bio-statistical support to maximize the Greehey Children’s Cancer Research Institute’s (Greehey CCRI) research productivity. As the Greehey CCRI gains new research faculty, the biostatistics needs will grow. |
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==See also== |
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* [[South Texas Medical Center]] |
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==References== |
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== Cancer Control == |
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{{reflist}} |
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Over the past three decades, great strides have been made in improving the survival of childhood cancer. Clinical research as shifted focus from improving survival to improving the quality of survival, especially for malignancies where we have achieved very high survival rates. |
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== Cancer Genetics == |
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The development of cancer involves a complex multi-step succession of molecular events involving the acquisition of mutations in proto-oncogenes, tumor suppressor genes and other genes that control, directly or indirectly, cell proliferation, cell cycle control, and cell death. |
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== Experimental Therapeutics == |
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Comparatively small numbers of children with cancer limit the definitive data from which to decide what, if any, benefit a novel anticancer agent may have in children. Hence there is a need for pre-clinical models of childhood cancer to screen the potential activity of new agents in transgenic or xenograft animal and cell culture models. |
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== Hematologic Malignancies == |
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Related to the fundamental basic research in molecular oncogenesis, we plan to establish a component of a larger trans-disciplinary program in hematologic malignancies at Greehey Children Cancer Research Institute. |
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== Molecular Oncogenesis == |
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The goal of the molecular oncogenesis and cancer genetics programs of the Greehey CCRI is to identify and characterize the genes, gene products, and pathways involved in pediatric cancers, recognizing that the study of pediatric cancer models has relevance to the problem of cancer in general. |
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== Pediatric Preclinical Testing Program (PPTP) == |
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The Pediatric Preclinical Testing Program (PPTP) is a comprehensive program to systematically evaluate new agents against childhood solid tumor and leukemia models. The PPTP is supported through an NCI research contract to The Research Institute at Nationwide Children’s Hospital with Dr. Peter Houghton as the Principal Investigator. |
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== Retinoblastoma Summer Program == |
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As part of their professional curriculum, students in the Doctor of Optometry program learn to conduct comprehensive pediatric eye exams and to assess for retinoblastoma. Optometry students from the Summer Fellowship Training Program at the Rosenberg School of Optometry (UIW) are participating in a collaborative research project with the Greehey Children’s Cancer Research Institute that aims to investigate the molecular basis of retinoblastoma. |
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== Vietnam Outreach Program == |
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In collaboration with the Kids With Cancer Foundation of Vietnam, our team members evaluated institutional capabilities as well as any possible impact of program implementation. We found that in southern Vietnam cancer survival was estimated as low as 5% compared to more than 90% survival for childhood ALL in the USA. Our current efforts focus on exposing and educating Vietnamese physicians to new techniques of diagnosis and management. |
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== Basic and Translational Science Award == |
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The Greehey Children’s Cancer Research Institute (Greehey CCRI), is soliciting proposals for pilot project awards. The primary goal of this program is to support early-stage collaborative basic and translational studies that will lead to increased interdisciplinary research likely to compete successfully for national grant support and ultimately to develop new drugs targeted to oncogenic ‘drivers’ of pediatric cancer. The program is supported through GCCRI institutional funds. |
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=== Core Facilities === |
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== Computational Biology & Bioinformatics Initiative == |
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The Computational Biology and Bioinformatics Initiative (CBBI) provides computational infrastructure, bioinformatics expertise, and interdisciplinary research to manage, distribute complex data sets, develop and perform bioinformatics tasks and statistical analyses in the area of genomics and systems biology. |
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== Genome Sequencing Facility (GSF) == |
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The Genome Sequencing Facility (GSF) at Greehey Children’s Cancer Research Institute in the UT Health San Antonio utilizes state-of-the-art genomic platforms to generate high-quality genomic data and provides support with its analysis. |
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== RNAi High Throughput Screening Facility == |
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The Greehey CCRI RNAi High Throughput Screening Facility’s goal is to collaborate with UT Health as well as with external investigators to conduct genome-wide RNAi screening projects, including assay development, screening, and gene validation, to understand functional biology of cancer and accelerate target discovery. |
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== Greehey CCRI Xenograft & Cell-Lines Core == |
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A GCCRI-based Xenograft and Cell Lines Core provides the service of preclinical testing of chemotherapeutics and combinations in mouse models. This Core is available to the UT Health San Antonio research community, the pharmaceutical companies, and any lab interested in conducting animal research. |
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=== Clinical === |
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Greehey CCRI interacts with members of the UT Health San Antonio, Division of Pediatric Hematology-Oncology to provide support for clinical research, banking of clinical specimens, and annotation of such specimens to facilitate patient-oriented research. In addition, as our clinical mission includes performing research that translates into clinical care, Greehey CCRI supports infrastructure for human subjects’ research and investigator-initiated trials in pediatric cancer. Since much of the research in pediatric cancer includes participation in cooperative group trials, Greehey CCRI supports the involvement of investigators in Children’s Oncology Group participation. |
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This year, the UT Health San Antonio MD Anderson Cancer Center, has become a member of The Pediatric Oncology Experimental Therapeutics Investigators’ Consortium (POETIC) pediatric oncology studies focus on the biologic basis for anti-cancer therapy, and in particular, attempt to explore and evaluate new agents and novel combinations of therapies early in clinical development. |
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=== Education === |
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The educational mission of the Greehey Children’s Cancer Research Institute is to train the next generation of researchers in pediatric cancer research. This includes creating a pipeline of trainees through our program for undergraduates engaged in summer research, medical students within the M.D. with Distinction in Research program, fellows in the ACGME-approved hematology-oncology fellowship program, as well as the traditional graduate programs in Cancer Biology and other relevant areas. We also provide a nurturing home for post-doctoral graduate research training. In the past five years, we have graduated 8 new Ph.Ds, and trained 4 pediatric oncology fellows as well as hosted several dozen summer undergraduate students. |
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==UT Health, San Antonio== |
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*[[Uthscsa.edu|WeMakeLivesBetter.com]] |
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==Academic Departments== |
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*[https://lsom.uthscsa.edu/biochemistry/ Biochemistry and Structural Biology] |
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*[https://lsom.uthscsa.edu/dcsa/ Cell Systems and Anatomy] |
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*[https://lsom.uthscsa.edu/molecular-medicine/ Molecular Medicine] |
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*[https://lsom.uthscsa.edu/pediatrics/ Pediatrics] |
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**[https://lsom.uthscsa.edu/pediatrics-hematology/ Division of Pediatric Hematology-Oncology] |
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*[[Population Health Sciences]] |
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{{UTHSCSA}} |
{{UTHSCSA}} |
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{{San Antonio}} |
{{San Antonio}} |
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[[Category:University of Texas System]] |
[[Category:University of Texas System]] |
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[[Category:South Texas Medical Center]] |
[[Category:South Texas Medical Center]] |
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[[Category:University of Texas Health Science Center at San Antonio]] |
[[Category:University of Texas Health Science Center at San Antonio]] |
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Latest revision as of 12:18, 14 September 2024
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The Greehey Children's Cancer Research Institute is a research center in San Antonio, Texas, US.
The institute was established in 1999 under a $200,000,000 endowment from the State of Texas tobacco settlement, at the time the largest single oncology endowment in US history. The $50 million facility was completed in 2004. The facility is part of the University of Texas Health Science Center at San Antonio.[1]
See also
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