Gilbert Ling: Difference between revisions
No edit summary Tag: possible birth date change |
Removed the pseudoscience claim for 'structured water.' While structured water products are likely scams + pseudoscience, it is undeniable that water has transient structures, even if femtosecond-long. Moreover, biomolecules are only a few multilayers of water apart in the cell on average, and a few layers of water are generally accepted to be polarized. |
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{{Short description|American scientist (1919–2019)}} |
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{{unbalanced|date=April 2018}} |
{{unbalanced|date=April 2018}} |
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{{Infobox scientist |
{{Infobox scientist |
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|website = |
|website = {{url|www.gilbertling.org}} |
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|name = Gilbert Ning Ling |
|name = Gilbert Ning Ling |
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|birth_name = |
|birth_name = |
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|image = Gilbert Ling Head Photo.jpg |
|image = Gilbert Ling Head Photo.jpg |
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|image_size = |
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|caption = |
|caption = Ling in 2001 |
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|birth_date = {{birth date|1919|12|26|df=yes}}<ref name=FahnestockRhetoric>{{cite book|last=Fahnestock|first=Jeanne|title=Rhetoric and incommensurability|year=2005|publisher=Parlor Press|location=West Lafayette, Ind.|isbn=978-1932559514|page=393|editor=Randy Allen Harris|chapter=Cell And Membrane}}</ref> |
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|birth_date = {{birth date|1919|12|26|df=yes}} |
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|birth_place = [[Nanjing]], [[Republic of China (1912-49)|Republic of China]] |
|birth_place = [[Nanjing]], [[Republic of China (1912-49)|Republic of China]] |
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|death_date = {{Death date|2019|11|10|df=yes}} |
|death_date = {{Death date and age|2019|11|10|1919|12|26|df=yes}} |
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|death_place = California, |
|death_place = [[California]], U.S. |
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|nationality = American |
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|citizenship = American |
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|nationality = |
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|ethnicity = [[Chinese people|Chinese]] |
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|doctoral_advisor = |
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|thesis_title = The effects of metabolism, temperature and other factors on the membrane potential of single frog muscle fibers |
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|thesis_year = 1948 |
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|thesis_url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458704/ |
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|awards = |
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|signature = |
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|children = 3 |
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|module = {{Infobox Chinese |
|module = {{Infobox Chinese |
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| s=凌宁 |
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| t=凌寧 |
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| p=Líng Níng}} |
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'''Gilbert Ning Ling''' ( |
'''Gilbert Ning Ling''' (December 26, 1919 – November 10, 2019) was a Chinese-born American [[Cell physiology|cell physiologist]], [[biochemist]] and scientific investigator. |
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In 1944 Ling won the biology slot of the sixth [[Boxer Indemnity Scholarship]], a nationwide competitive examination that allowed Chinese science and engineering students full scholarship to study in a United States university. In 1947 he co-developed the [[#Gerard-Graham-Ling microelectrode|Gerard-Graham-Ling microelectrode]], a device that allows scientists to more accurately measure the [[Electric potential|electrical potentials]] of living cells. In 1962<ref name=physicaltheory /> he proposed the Association induction hypothesis, which claims to be unifying, general theory of the living [[Cell (biology)|cell]], and is an alternative and controversial hypothesis<ref>{{cite journal|last1=Ling|first1=Gilbert|title=An Unanswered 2003 Letter Appealing on Behalf of all Mankind to Nobel Laureate Roderick McKinnon to Use His Newfound Fame and Visibility to Begin Restoring Honesty and Integrity to Basic Biomedical Science by Rebutting or Correcting Suspected Plagiarism in His Nobel-Prize-Winning Work|journal=Physiol. Chem. Phys. & Med. NMR|date=2007|volume=39|pages=89–106|url=http://www.physiologicalchemistryandphysics.com/pdf/PCP39-89_ling.pdf}}</ref><ref name=KnownCriticisms>{{cite web|last1=Ling|first1=Gilbert|title=List of all known printed criticisms of the AI Hypothesis and their full rebuttal|url=http://www.gilbertling.org/lp7.htm|website=gilbertling.org| |
In 1944, Ling won the biology slot of the sixth [[Boxer Indemnity Scholarship]], a nationwide competitive examination that allowed Chinese science and engineering students full scholarship to study in a United States university. In 1947 he co-developed the [[#Gerard-Graham-Ling microelectrode|Gerard-Graham-Ling microelectrode]], a device that allows scientists to more accurately measure the [[Electric potential|electrical potentials]] of living cells. In 1962<ref name=physicaltheory /> he proposed the Association induction hypothesis, which claims to be unifying, general theory of the living [[Cell (biology)|cell]], and is an alternative and controversial hypothesis<ref>{{cite journal|last1=Ling|first1=Gilbert|title=An Unanswered 2003 Letter Appealing on Behalf of all Mankind to Nobel Laureate Roderick McKinnon to Use His Newfound Fame and Visibility to Begin Restoring Honesty and Integrity to Basic Biomedical Science by Rebutting or Correcting Suspected Plagiarism in His Nobel-Prize-Winning Work|journal=Physiol. Chem. Phys. & Med. NMR|date=2007|volume=39|issue=1|pages=89–106|url=http://www.physiologicalchemistryandphysics.com/pdf/PCP39-89_ling.pdf|pmid=18613642}}</ref><ref name=KnownCriticisms>{{cite web|last1=Ling|first1=Gilbert|title=List of all known printed criticisms of the AI Hypothesis and their full rebuttal|url=http://www.gilbertling.org/lp7.htm|website=gilbertling.org|access-date=}}</ref><ref>{{cite journal|last1=Harold|first1=Franklin M|title=Book Review of Life at the Cell and Below-Cell Level: The Hidden History of a Fundamental Revolution in Biology|journal=Cell Biology International|date=2002|volume=26|issue=11|pages=1007–1009|doi=10.1006/cbir.2002.0948}}</ref> to the [[History of cell membrane theory|membrane]] and [[Cell theory#Emergence of the steady-state membrane pump concept|steady-state membrane pump]] theories, and three years later added the Polarized-Oriented Multilayer (PM or POM) theory of cell [[water]]. |
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Ling |
Ling carried out scientific experiments that attempted to disprove the accepted view of the cell as a [[Cell membrane|membrane]] containing a number of pumps such as the [[sodium potassium pump]] and the [[calcium pump]] and [[Transmembrane channels|channels]] that engage in [[Active Transport|active transport]].<ref name="HistoricallySignificantStudy">{{cite journal|last=Ling|first=Gilbert|title=A Historically Significant Study that at Once Disproves the Membrane (Pump)Theory and Confirms that Nano-protoplasm Is the Ultimate Physical Basis of Life— Yet so Simple and Low-cost that it Could Easily Be Repeated in Many High School Biology Classrooms Worldwide|year=2008|volume=40|issue=1|pages=89–113|url=http://www.physiologicalchemistryandphysics.com/pdf/PCP40_ling_ochsenfeld.pdf|access-date=15 February 2014}}</ref><ref name="DebunkingAlleged">{{cite journal|last=Ling|first=Gilbert|title=Debunking the Alleged Resurrection of the Sodium Pump Hypothesis|journal=Physiological Chemistry and Physics and Medical NMR|year=1997|volume=29|issue=1|pages=123–198|url=http://www.gilbertling.org/Debunking.pdf|access-date=15 February 2014|pmid=9654772|archive-date=20 September 2013|archive-url=https://web.archive.org/web/20130920073908/http://gilbertling.org/Debunking.pdf|url-status=dead}}</ref> |
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<ref name="DebunkingAlleged">{{cite journal|last=Ling|first=Gilbert|title=Debunking the Alleged Resurrection of the Sodium Pump Hypothesis |
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He died in November 2019, one month short of turning 100.<ref>[https://forum.jackkruse.com/index.php?attachments/gilbert-ling-in-memoriam-pdf.14085/ In Memoriam: Gilbert Ling]{{Dead link|date=December 2022 |bot=InternetArchiveBot |fix-attempted=yes }}</ref><ref>[https://www.ancestry.co.uk/family-tree/person/tree/34566069/person/132162691033/facts Ancestry: Gilbert Ling]</ref> |
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|year=1997|volume=29|issue=1|pages=123–198|url=http://www.gilbertling.org/Debunking.pdf|accessdate=15 February 2014}}</ref> the accepted view of the cell as a [[Cell membrane|membrane]] containing a number of pumps such as the [[sodium potassium pump]] and the [[calcium pump]] and [[Transmembrane channels|channels]] that engage in [[Active Transport|active transport]]. |
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== Early life and education == |
== Early life and education == |
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Ling was born December |
Ling was born in December 1919, in [[Nanjing]], China. He grew up in [[Beijing]] and entered the [[National Central University]] ([[Nanking University]]) in [[Chongqing]] as a student of [[animal husbandry]]. After two years, he transferred to the biology department and received a [[Biology]] [[B.Sc. degree]], minoring in [[physics]] and [[chemistry]] in 1943.<ref name=LifeAtTheCell>{{cite book|last=Ling|first=Gilbert|title=Life at the cell and below-cell level : the hidden history of a fundamental revolution in biology|year=2001|publisher=Pacific Press|location=Melville, NY|isbn=978-0-9707322-0-0|pages=[https://archive.org/details/lifeatcellbelowc00ling/page/371 371–373]|chapter-url=http://www.bioparadigma.spb.ru/hidden_history/aboutauthor.htm|edition=Original|chapter=About the author|url=https://archive.org/details/lifeatcellbelowc00ling/page/371}}</ref> |
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In 1944, having done graduate work in [[Biochemistry]] at the [[National Southwestern Associated University]] (National [[Tsinghua |
In 1944, having done graduate work in [[Biochemistry]] at the [[National Southwestern Associated University]] (National [[Tsinghua University]]) in [[Kunming]], Ling won the sixth [[#Boxer indemnity scholarship|Boxer Indemnity Scholarship]]. In early 1946 he began his graduate study in the department of physiology at the [[University of Chicago]] under [[Ralph W. Gerard|Professor Ralph W. Gerard]]. In 1948 he completed his [[Ph.D. dissertation|Ph.D]] on the effects of metabolism, temperature and other factors on the membrane potential of single frog muscle fibers which was published in Dec 1949 in a series of 4 papers in the [[Journal of Cellular Physiology|Journal of Cellular and Comparative Physiology]], Volume 34, Issue 3.<ref name=1949NormalMembranePotential>{{cite journal|last=Ling|first=Gilbert|author2=Gerard, R. W.|title=The normal membrane potential of frog sartorius fibers|journal=Journal of Cellular and Comparative Physiology|date=December 1949|volume=34|issue=3|pages=383–396|doi=10.1002/jcp.1030340304|pmid=15410483}}</ref><ref>{{cite journal|last=Ling|first=G.|author2=Gerard, R. W.|title=The influence of stretch on the membrane potential of the striated muscle fiber|journal=Journal of Cellular and Comparative Physiology|date=December 1949|volume=34|issue=3|pages=397–405|doi=10.1002/jcp.1030340305|pmid=15406359}}</ref><ref>{{cite journal|last=Ling|first=G.|author2=Woodbury, J. W.|title=Effect of temperature on the membrane potential of frog muscle fibers|journal=Journal of Cellular and Comparative Physiology|date=December 1949|volume=34|issue=3|pages=407–412|doi=10.1002/jcp.1030340306|pmid=15406360}}</ref><ref>{{cite journal|last=Ling|first=G.|author2=Gerard, R. W.|title=The membrane potential and metabolism of muscle fibers|journal=Journal of Cellular and Comparative Physiology|date=December 1949|volume=34|issue=3|pages=413–438|doi=10.1002/jcp.1030340307|pmid=15406361}}</ref> He spent two more years under Prof. Gerard as a Seymour Coman [[Postdoctoral Fellow]]. |
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== Academic career == |
== Academic career == |
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In 1944, Ling won the only [[ |
In 1944, Ling won the only [[biology]] slot of the sixth nationwide [[Boxer Indemnity Scholarship Program|Boxer Indemnity Fellowship]], to study [[physiology]] in the United States, which he took up in January 1946.<ref name=HistoryOfMembranePump>{{cite journal|last=Ling|first=Gilbert|title=History of the Membrane (Pump) Theory of the Living Cell from Its Beginning in Mid-19th Century to Its Disproof 45 Years Ago — though Still Taught Worldwide Today as Established Truth|journal=Physiological Chemistry and Physics and Medical NMR|year=2007|volume=39|issue=1|pages=46–49|url=http://www.physiologicalchemistryandphysics.com/pdf/PCP39-1.pdf|access-date=15 February 2014}}</ref> |
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From 1950 |
From 1950 to 1953 Ling worked as an instructor at the medical school of the [[Johns Hopkins University]] in [[Baltimore]]. His research and experiments led him to the conclusion that the mainstream membrane pump theory of the living cell was not correct. This early embryonic version of the [[#Association induction hypothesis|association induction hypothesis]] was called Ling's fixed charge hypothesis (LFCH). |
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From 1953 |
From 1953 to 1957, he continued full-time research at the [[Neuropsychiatric]] Institute at the [[University of Illinois College of Medicine|University of Illinois Medical School]] in [[Chicago]]. Beginning as an assistant professor, he was promoted two years later to ([[tenure]]d) associate professorship. |
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In 1957, he accepted the position of |
In 1957, he accepted the position of senior research scientist at the [[basic research]] department of the newly founded [[Pennsylvania State Hospitals|Eastern Pennsylvania Psychiatric Institute]]. |
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In 1962 his first book entitled |
In 1962 his first book, entitled ''A Physical Theory of the Living State: the Association-Induction Hypothesis'',<ref name=physicaltheory>{{cite book|last=Ling|first=Gilbert N|title=A Physical Theory of the Living State: the Association-Induction Hypothesis|year=1962|publisher=Blaisdell Publishing Company, A Division of Random House, Inc., London.|url=http://www.bioparadigma.spb.ru/files/Ling-1962-A.physical.theory.of.the.living.state.djvu|archive-url=https://web.archive.org/web/20160204225836/http://bioparadigma.spb.ru/files/Ling-1962-A.physical.theory.of.the.living.state.djvu|archive-date=2016-02-04}}</ref> was published. At this time Ling became director of a research laboratory at the [[Pennsylvania Hospital]] in [[Philadelphia]]. |
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[[File:Gilbert Ling (Younger).jpg|thumb|Ling in 1962 after publication of his first book]] |
[[File:Gilbert Ling (Younger).jpg|thumb|Ling in 1962 after publication of his first book]] |
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In 1984, Ling published his second book |
In 1984, Ling published his second book, ''In Search of the Physical Basis of Life''.<ref name=SeachPhysical>{{cite book|last1=Ling|first1=Gilbert N.|title=In search of the physical basis of life|date=1984|publisher=Plenum Press|location=New York|isbn=978-0-306-41409-1}}</ref> |
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⚫ | In October 1988, Ling's laboratory shut down due to his inability to obtain research funds from [[National Institutes of Health]] and other funding agencies. [[Raymond Vahan Damadian]] offered to support him and two of his staff, Margaret Ochsenfeld and Dr. Zhen-dong Chen.{{citation needed|date=April 2018}} |
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⚫ | From 1982 to 1985 he was a co–[[editor-in-chief]] of the ''Physiological Chemistry & Physics and Medical NMR'' journal and after 1986 served as sole editor-in-chief.<ref name=LifeAtCellBookAcknowledgments>{{cite book|last=Ling|first=Gilbert N.|title=Life at the cell and below-cell level : the hidden history of a fundamental revolution in biology|year=2001|publisher=Pacific Press|location=[Melville, NY]|isbn=978-0-9707322-0-0|page=[https://archive.org/details/lifeatcellbelowc00ling/page/368 368]|edition=Original|url=https://archive.org/details/lifeatcellbelowc00ling/page/368}}</ref> |
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⚫ | In 1992 Ling published his third book, ''A Revolution in the Physiology of the Living Cell''.<ref name=RevolutionInThePhysiology>{{cite book|last=Ling|first=Gilbert N.|title=A revolution in the physiology of the living cell|year=1992|publisher=Krieger Pub. Co.|location=Malabar, Fla.|isbn=978-0894643989|edition=Original ed. 1992.}}</ref> |
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⚫ | In October 1988, Ling's laboratory shut down due to his inability to obtain research funds from [[National Institutes of Health]] and other funding agencies. [[Raymond Vahan Damadian]] offered to support him and two of his staff |
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⚫ | From 1982 to 1985 he was a |
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⚫ | In 1992 Ling published his third book, |
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In 2011 his wife of |
In 2011 his wife of sixty years, Shirley Wang Ling, died of [[pancreatic cancer]].<ref name=WhatIsLifeAnswered>{{cite book|last=Ling|first=Gilbert|title=What is Life Answered|year=2013|isbn=978-0-615-94793-8|page=5|publisher=Gilbert N. Ling }}</ref> |
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In 2014 at the age of |
In 2014, at the age of ninety-four, he published his fifth book, ''What is Life Answered'', a response to [[Erwin Schrödinger]]'s 1944 book ''[[What is Life?]]''<ref name=WhatIsLifeAnswered /> |
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He |
He published over two hundred scientific papers,<ref name=LingPubMed>[https://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Ling%2BGN PubMed Documents by Gilbert Ling]</ref> although much of his later work was largely ignored by the [[scientific community]]. |
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== Gerard-Graham-Ling microelectrode == |
== Gerard-Graham-Ling microelectrode == |
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[[John Eccles (neurophysiologist)|John Eccles]] applied the microelectrode to studies of activity of individual units within the spinal cord and brain and [[Andrew Huxley]] used it in muscle cells. |
[[John Eccles (neurophysiologist)|John Eccles]] applied the microelectrode to studies of activity of individual units within the spinal cord and brain and [[Andrew Huxley]] used it in muscle cells. |
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In 1963, Hodgkin with Huxley, won the [[Nobel Prize in Physiology or Medicine]] for their work on the basis of nerve "[[action potential]]s," the electrical impulses which enable the activity of an organism to be coordinated by a [[central nervous system]]. Hodgkin and Huxley shared the prize that year with [[John Eccles (neurophysiologist)|John Eccles]], who was cited for his research on [[synapse]]s.<ref name="frs">{{Cite journal | last1 = Huxley | first1 = S. A. | |
In 1963, Hodgkin with Huxley, won the [[Nobel Prize in Physiology or Medicine]] for their work on the basis of nerve "[[action potential]]s," the electrical impulses which enable the activity of an organism to be coordinated by a [[central nervous system]]. Hodgkin and Huxley shared the prize that year with [[John Eccles (neurophysiologist)|John Eccles]], who was cited for his research on [[synapse]]s.<ref name="frs">{{Cite journal | last1 = Huxley | first1 = S. A. | author-link = Andrew Huxley| doi = 10.1098/rsbm.1999.0081 | title = Sir Alan Lloyd Hodgkin, O.M., K.B.E. 5 February 1914 -- 20 December 1998: Elected F.R.S. 1948 | journal = [[Biographical Memoirs of Fellows of the Royal Society]] | volume = 46 | pages = 219–241| year = 2000 | title-link = Alan Lloyd Hodgkin | doi-access = free }}</ref> |
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Worldwide use of this new microelectrode spread rapidly after this<ref>{{cite journal|last=Ling|first=Gilbert|title=History of the Membrane (Pump) Theory of the Living Cell from Its Beginning in Mid-19th Century to Its Disproof 45 Years Ago — though Still Taught Worldwide Today as Established Truth|journal=Physiological Chemistry and Physics and Medical NMR|year=2007|volume=39|issue=1|pages=46–49|url=http://www.physiologicalchemistryandphysics.com/pdf/PCP39-1.pdf}}</ref> and has subsequently proven to be one of the most important devices applied to the study of cellular physiology.<ref>NIH Summary Statement 1 R011 HL 39249-01 (April 30, 1987)</ref><ref name=LifeAtCellAboutAuthorWeb>{{cite web|last=Ling|first=Gilbert|title=Life at the Cell and Below-Cell Level About Author|url=http://www.pacificpressnewyork.com/author.html|work=Pacific Press New York| |
Worldwide use of this new microelectrode spread rapidly after this<ref>{{cite journal|last=Ling|first=Gilbert|title=History of the Membrane (Pump) Theory of the Living Cell from Its Beginning in Mid-19th Century to Its Disproof 45 Years Ago — though Still Taught Worldwide Today as Established Truth|journal=Physiological Chemistry and Physics and Medical NMR|year=2007|volume=39|issue=1|pages=46–49|url=http://www.physiologicalchemistryandphysics.com/pdf/PCP39-1.pdf}}</ref> and has subsequently proven to be one of the most important devices applied to the study of cellular physiology.<ref>NIH Summary Statement 1 R011 HL 39249-01 (April 30, 1987)</ref><ref name=LifeAtCellAboutAuthorWeb>{{cite web|last=Ling|first=Gilbert|title=Life at the Cell and Below-Cell Level About Author|url=http://www.pacificpressnewyork.com/author.html|work=Pacific Press New York|access-date=25 February 2014}}</ref> |
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The microelectrode in use today is essentially the same as this, except that it usually contains a concentrated salt solution, and is commonly referred to as the glass capillary.<ref>{{cite book|editor=Romain Brette|editor2=Alain Destexhe|title=Handbook of neural activity measurement|year=2012|publisher=Cambridge University Press|location=Cambridge, UK|isbn=9780521516228|page=47|url=http://cns.iaf.cnrs-gif.fr/files/ChapIntra2008.pdf}}</ref> |
The microelectrode in use today is essentially the same as this, except that it usually contains a concentrated salt solution, and is commonly referred to as the glass capillary.<ref>{{cite book|editor=Romain Brette|editor2=Alain Destexhe|title=Handbook of neural activity measurement|year=2012|publisher=Cambridge University Press|location=Cambridge, UK|isbn=9780521516228|page=47|url=http://cns.iaf.cnrs-gif.fr/files/ChapIntra2008.pdf}}</ref> |
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In 1950 Gerard was nominated for the [[Nobel Prize]] for helping to develop the [[microelectrode]] as used in [[ |
In 1950 Gerard was nominated for the [[Nobel Prize]] for helping to develop the [[microelectrode]] as used in [[electrophysiology]]. |
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== Association induction hypothesis == |
== Association induction hypothesis == |
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An alternative and controversial hypothesis<ref name=KnownCriticisms /> to the [[History of cell membrane theory|membrane]] and [[Cell theory# |
An alternative and controversial hypothesis<ref name=KnownCriticisms /> to the [[History of cell membrane theory|membrane]] and [[Cell theory#Emergence of the steady-state membrane pump concept|membrane pump]] theories, the association induction hypothesis<ref>{{cite web|last=Ling|first=Gilbert|title=Some High Lights of the Association-Induction Hypothesis|url=http://www.gilbertling.org/lp6c.htm}}</ref> is a claim related to the properties and activities of microscopic assemblies of molecules, atoms, ions, and electrons of the smallest unit of life called nano-[[protoplasm]].<ref>{{cite journal|last=Ling|first=G|title=Nano-protoplasm: the ultimate unit of life.|journal=Physiological Chemistry and Physics and Medical NMR|year=2007|volume=39|issue=2|pages=111–234|pmid=19256352|url=http://www.physiologicalchemistryandphysics.com/pdf/PCP39-2_ling.pdf}}</ref> |
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Ling wrote books describing his hypothesis in 1962<ref name=physicaltheory /> and 1984;<ref name=SeachPhysical /> and later self-published other books.<ref name=LifeAtTheCell /><ref name=WhatIsLifeAnswered /> |
Ling wrote books describing his hypothesis in 1962<ref name=physicaltheory /> and 1984;<ref name=SeachPhysical /> and later self-published other books.<ref name=LifeAtTheCell /><ref name=WhatIsLifeAnswered /> |
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== Polarized-oriented multilayer theory == |
== Polarized-oriented multilayer theory == |
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⚫ | In 1965, Ling added his polarized-oriented multilayer<ref>{{cite journal|last=Ling|first=Gilbert Ning|title=The Physical State of Water in Living Cell and Model Systems|journal=Annals of the New York Academy of Sciences|date=16 December 2006|volume=125|issue=2|pages=401–417|doi=10.1111/j.1749-6632.1965.tb45406.x|pmid=5221079|citeseerx=10.1.1.612.9201|s2cid=1545983}}</ref> of cell water to the [[#Association induction hypothesis|association induction hypothesis]]. The theory argues that intracellular water is [[polarizability|polarized]] and oriented and thus dynamically structured. |
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== Criticism == |
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⚫ | In 1965, Ling added his |
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In 1974, Lawrence G. Palmer and Jagdish Gulati tested one aspect of Ling's theories; namely, whether potassium ions within the cell are bound or free. Contrary to Ling's prediction, they found that in fact potassium ions within frog [[skeletal muscle]] cells are free.<ref>{{cite journal |last1=Palmer |first1=Lawrence |last2=Gulati |first2=Jagdish |title=Potassium Accumulation in Muscle: A Test of the Binding Hypothesis |journal=Science |date=29 Oct 1976 |volume=194 |issue=4264 |pages=521–523 |doi=10.1126/science.1085986 |pmid=1085986 |bibcode=1976Sci...194..521P |url=https://www.science.org/doi/abs/10.1126/science.1085986}}</ref> |
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More recent studies by Gerald Pollack (2001, 2013)<ref>{{cite journal|last=Das|first=Ronnie|author2=Pollack, Gerald H.|title=Charge-Based Forces at the Nafion–Water Interface|journal=Langmuir|date=26 February 2013|volume=29|issue=8|pages=2651–2658|doi=10.1021/la304418p|pmid=23311934|pmc=3883427}}</ref><ref>{{cite book|last=Pollack|first=Gerald H.|title=Cells, gels and the engines of life : a new, unifying approach to cell function|year=2001|publisher=Ebner & Sons|location=Seattle|isbn=978-0962689529}}</ref><ref>{{cite book|last=Pollack|first=Gerald H.|title=The fourth phase of water : beyond solid, liquid, and vapor|year=2013|publisher=Ebner and Sons|location=Seattle|isbn=978-0962689543}}</ref> and [[Mae-Wan Ho]] (2008, 2012)<ref>{{cite book|last=Ho|first=Mae-Wan|title=The rainbow and the worm : the physics of organisms|year=2008|publisher=World Scientific|location=Singapore|isbn=978-9812832603|edition=3rd}}</ref><ref>{{cite book|last=Ho|first=Mae-Wan|title=Living rainbow H₂O|year=2012|publisher=World Scientific|location=Singapore|isbn=978-9814390897}}</ref> have confirmed the structured nature of cell water and |
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some scientists such as Vladimir Matveev (2012) continue to explore the ideas that Ling introduced in the 1960s.<ref>{{cite journal|author=Laurent Jaeken|author2=Vladimir Matveev|last-author-amp=yes|title=Coherent Behavior and the Bound State of Water and K+ Imply Another Model of Bioenergetics: Negative Entropy Instead of High-energy Bonds|journal=The Open Biochemistry Journal|date=Sep 2012|volume=6|pages=139–159|pmc=3527877|pmid=23264833|doi=10.2174/1874091X01206010139}}</ref><ref>{{cite journal|last1=Matveev|first1=VV|title=Native aggregation as a cause of origin of temporary cellular structures needed for all forms of cellular activity, signaling and transformations.|journal=Theoretical Biology & Medical Modelling|date=Jun 2010 |volume=7|pages=19|doi=10.1186/1742-4682-7-19|pmid=20534114|pmc=2901313}}</ref> |
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== See also == |
== See also == |
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== References == |
== References == |
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{{ |
{{reflist}} |
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== Publications == |
== Publications == |
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{{DEFAULTSORT:Ling, Gilbert}} |
{{DEFAULTSORT:Ling, Gilbert}} |
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[[Category:1919 births]] |
[[Category:1919 births]] |
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[[Category:Boxer Indemnity Scholarship recipients]] |
[[Category:Boxer Indemnity Scholarship recipients]] |
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[[Category:Chinese emigrants to the United States]] |
[[Category:Chinese emigrants to the United States]] |
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[[Category:National Central University alumni]] |
[[Category:National Central University alumni]] |
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Latest revision as of 18:53, 18 September 2024
This article may be unbalanced toward certain viewpoints. (April 2018) |
Gilbert Ning Ling | |||||||
---|---|---|---|---|---|---|---|
Born | [1] | 26 December 1919||||||
Died | 10 November 2019 California, U.S. | (aged 99)||||||
Nationality | American | ||||||
Alma mater | National Central University (B.S.) University of Chicago (Ph.D.) | ||||||
Spouse |
Shirley Wang Ling
(m. 1951–2011) | ||||||
Children | 3 | ||||||
Scientific career | |||||||
Fields | Cell biology Cell physiology Molecular biology Cell membrane | ||||||
Institutions | National Central University University of Chicago Johns Hopkins University University of Illinois Pennsylvania Hospital Fonar Corp. Basic Research Dept | ||||||
Thesis | The effects of metabolism, temperature and other factors on the membrane potential of single frog muscle fibers (1948) | ||||||
Chinese name | |||||||
Traditional Chinese | 凌寧 | ||||||
Simplified Chinese | 凌宁 | ||||||
| |||||||
Website | www |
Gilbert Ning Ling (December 26, 1919 – November 10, 2019) was a Chinese-born American cell physiologist, biochemist and scientific investigator.
In 1944, Ling won the biology slot of the sixth Boxer Indemnity Scholarship, a nationwide competitive examination that allowed Chinese science and engineering students full scholarship to study in a United States university. In 1947 he co-developed the Gerard-Graham-Ling microelectrode, a device that allows scientists to more accurately measure the electrical potentials of living cells. In 1962[2] he proposed the Association induction hypothesis, which claims to be unifying, general theory of the living cell, and is an alternative and controversial hypothesis[3][4][5] to the membrane and steady-state membrane pump theories, and three years later added the Polarized-Oriented Multilayer (PM or POM) theory of cell water.
Ling carried out scientific experiments that attempted to disprove the accepted view of the cell as a membrane containing a number of pumps such as the sodium potassium pump and the calcium pump and channels that engage in active transport.[6][7]
He died in November 2019, one month short of turning 100.[8][9]
Early life and education
[edit]Ling was born in December 1919, in Nanjing, China. He grew up in Beijing and entered the National Central University (Nanking University) in Chongqing as a student of animal husbandry. After two years, he transferred to the biology department and received a Biology B.Sc. degree, minoring in physics and chemistry in 1943.[10]
In 1944, having done graduate work in Biochemistry at the National Southwestern Associated University (National Tsinghua University) in Kunming, Ling won the sixth Boxer Indemnity Scholarship. In early 1946 he began his graduate study in the department of physiology at the University of Chicago under Professor Ralph W. Gerard. In 1948 he completed his Ph.D on the effects of metabolism, temperature and other factors on the membrane potential of single frog muscle fibers which was published in Dec 1949 in a series of 4 papers in the Journal of Cellular and Comparative Physiology, Volume 34, Issue 3.[11][12][13][14] He spent two more years under Prof. Gerard as a Seymour Coman Postdoctoral Fellow.
Academic career
[edit]In 1944, Ling won the only biology slot of the sixth nationwide Boxer Indemnity Fellowship, to study physiology in the United States, which he took up in January 1946.[15]
From 1950 to 1953 Ling worked as an instructor at the medical school of the Johns Hopkins University in Baltimore. His research and experiments led him to the conclusion that the mainstream membrane pump theory of the living cell was not correct. This early embryonic version of the association induction hypothesis was called Ling's fixed charge hypothesis (LFCH).
From 1953 to 1957, he continued full-time research at the Neuropsychiatric Institute at the University of Illinois Medical School in Chicago. Beginning as an assistant professor, he was promoted two years later to (tenured) associate professorship.
In 1957, he accepted the position of senior research scientist at the basic research department of the newly founded Eastern Pennsylvania Psychiatric Institute.
In 1962 his first book, entitled A Physical Theory of the Living State: the Association-Induction Hypothesis,[2] was published. At this time Ling became director of a research laboratory at the Pennsylvania Hospital in Philadelphia.
In 1984, Ling published his second book, In Search of the Physical Basis of Life.[16]
In October 1988, Ling's laboratory shut down due to his inability to obtain research funds from National Institutes of Health and other funding agencies. Raymond Vahan Damadian offered to support him and two of his staff, Margaret Ochsenfeld and Dr. Zhen-dong Chen.[citation needed]
From 1982 to 1985 he was a co–editor-in-chief of the Physiological Chemistry & Physics and Medical NMR journal and after 1986 served as sole editor-in-chief.[17]
In 1992 Ling published his third book, A Revolution in the Physiology of the Living Cell.[18]
In 2001 his fourth book, Life at the Cell and Below-Cell Level,[10] was published and subsequently translated into Russian and Chinese.
In 2011 his wife of sixty years, Shirley Wang Ling, died of pancreatic cancer.[19] In 2014, at the age of ninety-four, he published his fifth book, What is Life Answered, a response to Erwin Schrödinger's 1944 book What is Life?[19] He published over two hundred scientific papers,[20] although much of his later work was largely ignored by the scientific community.
Gerard-Graham-Ling microelectrode
[edit]Also known as the Ling-Gerard microelectrode and after the 1940s further developed into the glass capillary microelectrode has played a vital role in modern neurophysiology and medicine. [citation needed]
John Eccles applied the microelectrode to studies of activity of individual units within the spinal cord and brain and Andrew Huxley used it in muscle cells.
In 1963, Hodgkin with Huxley, won the Nobel Prize in Physiology or Medicine for their work on the basis of nerve "action potentials," the electrical impulses which enable the activity of an organism to be coordinated by a central nervous system. Hodgkin and Huxley shared the prize that year with John Eccles, who was cited for his research on synapses.[21] Worldwide use of this new microelectrode spread rapidly after this[22] and has subsequently proven to be one of the most important devices applied to the study of cellular physiology.[23][24] The microelectrode in use today is essentially the same as this, except that it usually contains a concentrated salt solution, and is commonly referred to as the glass capillary.[25] In 1950 Gerard was nominated for the Nobel Prize for helping to develop the microelectrode as used in electrophysiology.
Association induction hypothesis
[edit]An alternative and controversial hypothesis[4] to the membrane and membrane pump theories, the association induction hypothesis[26] is a claim related to the properties and activities of microscopic assemblies of molecules, atoms, ions, and electrons of the smallest unit of life called nano-protoplasm.[27]
Ling wrote books describing his hypothesis in 1962[2] and 1984;[16] and later self-published other books.[10][19]
Polarized-oriented multilayer theory
[edit]In 1965, Ling added his polarized-oriented multilayer[28] of cell water to the association induction hypothesis. The theory argues that intracellular water is polarized and oriented and thus dynamically structured.
Criticism
[edit]In 1974, Lawrence G. Palmer and Jagdish Gulati tested one aspect of Ling's theories; namely, whether potassium ions within the cell are bound or free. Contrary to Ling's prediction, they found that in fact potassium ions within frog skeletal muscle cells are free.[29]
See also
[edit]References
[edit]- ^ Fahnestock, Jeanne (2005). "Cell And Membrane". In Randy Allen Harris (ed.). Rhetoric and incommensurability. West Lafayette, Ind.: Parlor Press. p. 393. ISBN 978-1932559514.
- ^ a b c Ling, Gilbert N (1962). A Physical Theory of the Living State: the Association-Induction Hypothesis. Blaisdell Publishing Company, A Division of Random House, Inc., London. Archived from the original on 2016-02-04.
- ^ Ling, Gilbert (2007). "An Unanswered 2003 Letter Appealing on Behalf of all Mankind to Nobel Laureate Roderick McKinnon to Use His Newfound Fame and Visibility to Begin Restoring Honesty and Integrity to Basic Biomedical Science by Rebutting or Correcting Suspected Plagiarism in His Nobel-Prize-Winning Work" (PDF). Physiol. Chem. Phys. & Med. NMR. 39 (1): 89–106. PMID 18613642.
- ^ a b Ling, Gilbert. "List of all known printed criticisms of the AI Hypothesis and their full rebuttal". gilbertling.org.
- ^ Harold, Franklin M (2002). "Book Review of Life at the Cell and Below-Cell Level: The Hidden History of a Fundamental Revolution in Biology". Cell Biology International. 26 (11): 1007–1009. doi:10.1006/cbir.2002.0948.
- ^ Ling, Gilbert (2008). "A Historically Significant Study that at Once Disproves the Membrane (Pump)Theory and Confirms that Nano-protoplasm Is the Ultimate Physical Basis of Life— Yet so Simple and Low-cost that it Could Easily Be Repeated in Many High School Biology Classrooms Worldwide" (PDF). 40 (1): 89–113. Retrieved 15 February 2014.
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(help) - ^ Ling, Gilbert (1997). "Debunking the Alleged Resurrection of the Sodium Pump Hypothesis" (PDF). Physiological Chemistry and Physics and Medical NMR. 29 (1): 123–198. PMID 9654772. Archived from the original (PDF) on 20 September 2013. Retrieved 15 February 2014.
- ^ In Memoriam: Gilbert Ling[permanent dead link ]
- ^ Ancestry: Gilbert Ling
- ^ a b c Ling, Gilbert (2001). "About the author". Life at the cell and below-cell level : the hidden history of a fundamental revolution in biology (Original ed.). Melville, NY: Pacific Press. pp. 371–373. ISBN 978-0-9707322-0-0.
- ^ Ling, Gilbert; Gerard, R. W. (December 1949). "The normal membrane potential of frog sartorius fibers". Journal of Cellular and Comparative Physiology. 34 (3): 383–396. doi:10.1002/jcp.1030340304. PMID 15410483.
- ^ Ling, G.; Gerard, R. W. (December 1949). "The influence of stretch on the membrane potential of the striated muscle fiber". Journal of Cellular and Comparative Physiology. 34 (3): 397–405. doi:10.1002/jcp.1030340305. PMID 15406359.
- ^ Ling, G.; Woodbury, J. W. (December 1949). "Effect of temperature on the membrane potential of frog muscle fibers". Journal of Cellular and Comparative Physiology. 34 (3): 407–412. doi:10.1002/jcp.1030340306. PMID 15406360.
- ^ Ling, G.; Gerard, R. W. (December 1949). "The membrane potential and metabolism of muscle fibers". Journal of Cellular and Comparative Physiology. 34 (3): 413–438. doi:10.1002/jcp.1030340307. PMID 15406361.
- ^ Ling, Gilbert (2007). "History of the Membrane (Pump) Theory of the Living Cell from Its Beginning in Mid-19th Century to Its Disproof 45 Years Ago — though Still Taught Worldwide Today as Established Truth" (PDF). Physiological Chemistry and Physics and Medical NMR. 39 (1): 46–49. Retrieved 15 February 2014.
- ^ a b Ling, Gilbert N. (1984). In search of the physical basis of life. New York: Plenum Press. ISBN 978-0-306-41409-1.
- ^ Ling, Gilbert N. (2001). Life at the cell and below-cell level : the hidden history of a fundamental revolution in biology (Original ed.). [Melville, NY]: Pacific Press. p. 368. ISBN 978-0-9707322-0-0.
- ^ Ling, Gilbert N. (1992). A revolution in the physiology of the living cell (Original ed. 1992. ed.). Malabar, Fla.: Krieger Pub. Co. ISBN 978-0894643989.
- ^ a b c Ling, Gilbert (2013). What is Life Answered. Gilbert N. Ling. p. 5. ISBN 978-0-615-94793-8.
- ^ PubMed Documents by Gilbert Ling
- ^ Huxley, S. A. (2000). "Sir Alan Lloyd Hodgkin, O.M., K.B.E. 5 February 1914 -- 20 December 1998: Elected F.R.S. 1948". Biographical Memoirs of Fellows of the Royal Society. 46: 219–241. doi:10.1098/rsbm.1999.0081.
- ^ Ling, Gilbert (2007). "History of the Membrane (Pump) Theory of the Living Cell from Its Beginning in Mid-19th Century to Its Disproof 45 Years Ago — though Still Taught Worldwide Today as Established Truth" (PDF). Physiological Chemistry and Physics and Medical NMR. 39 (1): 46–49.
- ^ NIH Summary Statement 1 R011 HL 39249-01 (April 30, 1987)
- ^ Ling, Gilbert. "Life at the Cell and Below-Cell Level About Author". Pacific Press New York. Retrieved 25 February 2014.
- ^ Romain Brette; Alain Destexhe, eds. (2012). Handbook of neural activity measurement (PDF). Cambridge, UK: Cambridge University Press. p. 47. ISBN 9780521516228.
- ^ Ling, Gilbert. "Some High Lights of the Association-Induction Hypothesis".
- ^ Ling, G (2007). "Nano-protoplasm: the ultimate unit of life" (PDF). Physiological Chemistry and Physics and Medical NMR. 39 (2): 111–234. PMID 19256352.
- ^ Ling, Gilbert Ning (16 December 2006). "The Physical State of Water in Living Cell and Model Systems". Annals of the New York Academy of Sciences. 125 (2): 401–417. CiteSeerX 10.1.1.612.9201. doi:10.1111/j.1749-6632.1965.tb45406.x. PMID 5221079. S2CID 1545983.
- ^ Palmer, Lawrence; Gulati, Jagdish (29 Oct 1976). "Potassium Accumulation in Muscle: A Test of the Binding Hypothesis". Science. 194 (4264): 521–523. Bibcode:1976Sci...194..521P. doi:10.1126/science.1085986. PMID 1085986.
Publications
[edit]- Gilbert N. Ling. A Physical Theory of the Living State: the Association-Induction Hypothesis. Blaisdell Publishing Company, A Division of Random House, Inc., London. 1962. 682 pages. Library of Congress Catalogue Number: 62-11835
- Gilbert N. Ling. In Search of the Physical Basis of Life. Plenum Press, New York and London. 1984. 791 pages. ISBN 0-306-41409-0
- Gilbert N. Ling. A Revolution in the Physiology of the Living Cell. Krieger Publishing Company, Malabar, Florida. 1992. 378 pages. ISBN 0-89464-398-3
- Gilbert N. Ling. Life at the Cell and Below-Cell Level: The Hidden History of a Fundamental. Revolution in Biology. New York: Pacific Press. 2001. 373 pages. ISBN 0-9707322-0-1
- Gilbert N. Ling. What is Life Answered. Cushing Malloy Inc., Ann Arbor, Michigan. 2013. 120 pages. ISBN 978-0-615-94793-8
External links
[edit]- 1919 births
- 2019 deaths
- Boxer Indemnity Scholarship recipients
- Chinese emigrants to the United States
- University of Chicago alumni
- National Central University alumni
- Nanjing University alumni
- Academic staff of Tsinghua University
- University of Chicago faculty
- Johns Hopkins University faculty
- University of Illinois faculty