Talk:Lorazepam: Difference between revisions
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== Potent Benzodiazipines == |
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== activan is a benzodiazepam, for instance == |
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{{reply to|DocJames}} I had changed "Potent benzodiazepines, such as lorazepam, [[alprazolam]], and [[triazolam]], have the highest risk of causing a dependence" to "Potent benzodiazepines, such as lorazepam, [[alprazolam]], and [[triazolam]], appear to have the highest risk of causing a dependence", to make the claim that was actually made in the reference. The relevant sentence in the reference is "Potent BZDs with relatively short t1/2 (e.g. triazolam, alprazolam and lorazepam) appear to carry the highest risk of dependence". The reference does not definitivey say that they ''do'' have the highest risk, it says that they ''appear to'' have the highest risk. Should we say what the reference being used actually says, or make a stronger statement than what the reference says? (Also, I'm going to add "with a relatively short half life" after "potent benzodiazepines", since that is also what the reference says. I won't add back "appear to have" for now.) [[User:Vontheri|Vontheri]] ([[User talk:Vontheri|talk]]) 18:31, 19 April 2019 (UTC) |
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ativan is a a benzodiazepam, as is xanax, clonepin, temazepam and valium. |
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== Flunitrazepam Inclusion/Facilitation of Criminal Activity == |
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the classification error presented here appears in medical literature online and has made it, at YNHH, into medical jargon and paperwork [[Special:Contributions/173.162.206.117|173.162.206.117]] ([[User talk:173.162.206.117|talk]]) 03:50, 2 November 2023 (UTC) |
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Under society and culture > recreational use, a paragraph is dedicated to discussing flunitrazepam's potential usage in facilitating criminal activity, especially date rape and robbery; however, flunitrazepam and the issue in general is not mentioned on any other pages dedicated to specific benzodiazepines, and there's little evidence that most common benzodiazpeines see appreciable usage in the above mentioned criminal activity, likely due to the fact that unlike flunitrazepam, other benzodiazepines generally possesses relatively minor polar solubility and thus will not dissolve readily in most common beverages, making it far more difficult to administer the drug without a subject's knowledge. |
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:The very first sentence of the article is, "Lorazepam, sold under the brand name Ativan among others, is a '''benzodiazepine''' medication." (emphasis added) Where are you seeing that it says that Ativan/lorazepam is not a benzodiazipine? [[User:Vontheri|Vontheri]] ([[User talk:Vontheri|talk]]) 21:03, 22 February 2024 (UTC) |
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In essence I feel the section is out of place and potentially confusing/misleading, but as someone not especially familiar with the dos and don'ts of wiki editing I don't feel comfortable just deleting it based purely on personal judgement, so I figured I'd at least bring it up here. [[Special:Contributions/100.19.116.119|100.19.116.119]] ([[User talk:100.19.116.119|talk]]) 17:57, 17 August 2019 (UTC) |
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== Availability == |
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As at end 2023 this medication is nowhere to be found in pharamacies or hospitals and there is a major holdup in production. Recent increases in demand, manufacturing changes, and quality control issues have resulted in a shortage of injectable and oral lorazepam, prompting clinicians to use alternatives. Should this be discussed here? Or does it belong in some separate article on thew recent significant increases in mental health problems worldwide? [[User:Carusus|Carusus]] ([[User talk:Carusus|talk]]) 11:07, 13 January 2024 (UTC) |
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DocJames and I seem to be having multiple disputes on various pages. I am a physician-pharmacologist who has been teaching at one of the largest research medical schools in the US for 26 years, but I don't get to editing Wikipedia often. When I do, it's to correct something just too absurd or troublesome to let go. The issue here is whether any benzodiazepine causes respiratory depression, and DocJames cites a Cochrane review focusing on a different subject in support of this relationship. This is not support because neither respiratory depression nor benzodiazepines was the focus of the review, and it is - indeed just a review of published work, not data in its own right. Actual primary data says something quite different, for example: G. E. Carraro, E. W. Russi, S. Buechi, and K. E. Bloch. Does oral alprazolam affect ventilation? A randomised, double-blind, placebo-controlled trial. Journal of Psychopharmacology 23 (3):322-327, 2009. Papers like this, done with modern methods, strongly deny a respiratory depressant effect of benzos, and can explain why earlier investigations were misinterpreted. |
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:@[[User:Carusus|Carusus]] As long as you have reliable sources to back up that information, then I see no reason why that shouldn't be included in this article. [[User:Vontheri|Vontheri]] ([[User talk:Vontheri|talk]]) 20:32, 22 February 2024 (UTC) |
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This isn't an idle discussion. The opioid overdose epidemic and its "association" with benzos is a very big deal in the US right now, with an immense amount of litigation surrounding it. In the midst of flaring accusations and repetitively-quoted misleading concepts, it is more important than ever to read the PRIMARY literature (not merely side issues mentioned in review literature). [[User:Verytas|Verytas]] ([[User talk:Verytas|talk]]) 17:04, 20 October 2019 (UTC) |
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::@[[User:Vontheri|Vontheri]] my comment is based on personal experience l. My son was in hospital in Switzerland at the time and the doctors explained the situation. |
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::I can do what usually passes for 'research' to corroborate. I remember reading various newspapers articles at the time. oK. unsubstantiated. I believe in providing concrete proof. Will do my best. Thanks [[User:Carusus|Carusus]] ([[User talk:Carusus|talk]]) 19:54, 1 October 2024 (UTC) |
Latest revision as of 19:54, 1 October 2024
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activan is a benzodiazepam, for instance
[edit]ativan is a a benzodiazepam, as is xanax, clonepin, temazepam and valium.
the classification error presented here appears in medical literature online and has made it, at YNHH, into medical jargon and paperwork 173.162.206.117 (talk) 03:50, 2 November 2023 (UTC)
- The very first sentence of the article is, "Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication." (emphasis added) Where are you seeing that it says that Ativan/lorazepam is not a benzodiazipine? Vontheri (talk) 21:03, 22 February 2024 (UTC)
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[edit]As at end 2023 this medication is nowhere to be found in pharamacies or hospitals and there is a major holdup in production. Recent increases in demand, manufacturing changes, and quality control issues have resulted in a shortage of injectable and oral lorazepam, prompting clinicians to use alternatives. Should this be discussed here? Or does it belong in some separate article on thew recent significant increases in mental health problems worldwide? Carusus (talk) 11:07, 13 January 2024 (UTC)
- @Carusus As long as you have reliable sources to back up that information, then I see no reason why that shouldn't be included in this article. Vontheri (talk) 20:32, 22 February 2024 (UTC)
- @Vontheri my comment is based on personal experience l. My son was in hospital in Switzerland at the time and the doctors explained the situation.
- I can do what usually passes for 'research' to corroborate. I remember reading various newspapers articles at the time. oK. unsubstantiated. I believe in providing concrete proof. Will do my best. Thanks Carusus (talk) 19:54, 1 October 2024 (UTC)