Flunisolide: Difference between revisions
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{{Short description|Chemical compound}} |
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{{Drugbox |
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{{Infobox drug |
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| Verifiedfields = changed |
| Verifiedfields = changed |
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| verifiedrevid = 461101454 |
| verifiedrevid = 461101454 |
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| image2 = Flunisolide ball-and-stick.png |
| image2 = Flunisolide ball-and-stick.png |
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<!--Clinical data--> |
<!--Clinical data--> |
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| tradename = Aerobid |
| tradename = Aerobid, Nasalide, Nasarel, others |
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| Drugs.com = {{drugs.com|monograph|flunisolide}} |
| Drugs.com = {{drugs.com|monograph|flunisolide}} |
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| MedlinePlus = a681048 |
| MedlinePlus = a681048 |
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| legal_status = |
| legal_status = |
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| routes_of_administration = Inhaled |
| routes_of_administration = Inhaled |
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<!--Pharmacokinetic data--> |
<!--Pharmacokinetic data--> |
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| bioavailability = |
| bioavailability = |
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| protein_bound = 40% after |
| protein_bound = 40% after inhalation |
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| metabolism = |
| metabolism = |
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| elimination_half-life = 1.8 hours |
| elimination_half-life = 1.8 hours |
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<!--Identifiers--> |
<!--Identifiers--> |
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| IUPHAR_ligand = 7076 |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CAS_number_Ref = {{cascite|correct|??}} |
| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 3385-03-3 |
| CAS_number = 3385-03-3 |
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| PubChem = 82153 |
| PubChem = 82153 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = DB00180 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 74144 |
| ChemSpiderID = 74144 |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = 1512 |
| ChEMBL = 1512 |
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<!--Chemical data--> |
<!--Chemical data--> |
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| C=24 | H=31 | F=1 | O=6 |
| C=24 | H=31 | F=1 | O=6 |
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| molecular_weight = 434.498 g/mol |
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| smiles = O=C\1\C=C/[C@]2(/C(=C/1)[C@@H](F)C[C@H]3[C@H]4[C@](C[C@H](O)[C@H]23)([C@@]5(OC(O[C@@H]5C4)(C)C)C(=O)CO)C)C |
| smiles = O=C\1\C=C/[C@]2(/C(=C/1)[C@@H](F)C[C@H]3[C@H]4[C@](C[C@H](O)[C@H]23)([C@@]5(OC(O[C@@H]5C4)(C)C)C(=O)CO)C)C |
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| InChI = 1/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1 |
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| InChIKey = XSFJVAJPIHIPKU-XWCQMRHXBG |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1 |
| StdInChI = 1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1 |
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| synonyms = <small>6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione acetone cyclic 16,17-acetal</small> |
| synonyms = <small>6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione acetone cyclic 16,17-acetal</small> |
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}} |
}} |
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<!-- Definition and medical uses --> |
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⚫ | '''Flunisolide''' (marketed as '''AeroBid''' among others) is a [[corticosteroid]] often prescribed as a treatment for [[allergic rhinitis]].<ref>{{cite web | title = Flunisolide | url = http://www.drugbank.ca/drugs/DB00180 | work = DrugBank }}</ref> Intranasal corticosteroids are the most effective medication for controlling symptoms.<ref name="auto">{{cite journal | vauthors = Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, Lang DM, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph CC, Schuller D, Spector SL, Tilles SA | display-authors = 6 | title = The diagnosis and management of rhinitis: an updated practice parameter | journal = The Journal of Allergy and Clinical Immunology | volume = 122 | issue = 2 Suppl | pages = S1-84 | date = August 2008 | pmid = 18662584 | doi = 10.1016/j.jaci.2008.06.003 | doi-access = free }}</ref> |
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<!-- Side effects and mechanisms --> |
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⚫ | '''Flunisolide''' (marketed as '''AeroBid''' |
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⚫ | Flunisolide's principal mechanism of action is to activate [[glucocorticoid]] receptors, indicating an [[anti-inflammatory]] action. The effects of topical corticosteroids are not immediate and must be used for at least a few days for noticeable relief. As-needed use is less effective than regular recommended use.<ref name="auto"/> Flunisolide should not be used for nasal infections. It should not be continued if symptoms are not relieved after regular use for over two to three weeks.<ref name="nih.gov">{{cite web | title = Flunisolide Nasal Solution | url = http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8ba9cc1c-55e5-40ed-9efe-f7abb73976ea | work = DailyMed | publisher = U.S. National Library of Medicine }}</ref> |
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<!-- Society and culture --> |
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⚫ | |||
Patented in 1958 and approved for medical use in 1978,<ref name=Fis2006>{{cite book | vauthors = Fischer J, Ganellin CR |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=486 |url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA486 |language=en}}</ref> it is on the [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].<ref name="WHO22nd">{{cite book | vauthors = ((World Health Organization)) | title = World Health Organization model list of essential medicines: 22nd list (2021) | year = 2021 | hdl = 10665/345533 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2021.02 | hdl-access=free }}</ref> |
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==Side effects== |
==Side effects== |
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Temporary nose and throat dryness, irritation, bleeding or unpleasant taste or smell may occur.<ref>http://www.medicinenet.com/flunisolide-nasal/page2.htm</ref> |
Temporary nose and throat dryness, irritation, bleeding, or unpleasant taste or smell may occur.<ref>{{cite web|url=http://www.medicinenet.com/flunisolide-nasal/page2.htm|title=FLUNISOLIDE - NASAL (Nasalide, Nasarel) side effects, medical uses, and drug interactions | work = MedicineNet }}</ref> [[Nasal septum perforation]] has been rarely reported.<ref name="auto"/> Rare but localized infections of the nose and pharynx with ''[[Candida albicans]]'' have also been reported. Its long-term use may raise the chances of cataracts or glaucoma.<ref name="rxlist.com" /> |
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Flunisolide nasal spray is absorbed into the [[circulatory system]] (blood).<ref |
Flunisolide nasal spray is absorbed into the [[circulatory system]] (blood).<ref name="nih.gov"/> Corticosteroid nasal sprays may affect the [[hypothalamic-pituitary-adrenal axis]] function in humans.<ref name="rxlist.com">{{cite web|url=http://www.rxlist.com/nasalide-drug/clinical-pharmacology.htm|title=Nasalide (Flunisolide (Nasal Spray)) Drug Information: Clinical Pharmacology - Prescribing Information | work = RxList }}</ref> After obtaining the desired clinical effect, the [[maintenance dose]] should be reduced to the smallest amount required to control the symptoms. The amount can be as low as one spray in each nostril daily. Utilizing the [[Effective dose (pharmacology)|minimum effective dose]] reduces possibility of side effects.<ref name="rxlist.com"/> Recommended amounts of intranasal corticosteroids are generally not associated with [[Systemic effect|systemic]] side effects. |
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Corticosteroids inhibit wound healing |
Corticosteroids inhibit wound healing, so corticosteroid nasal sprays should be used cautiously in patients who have experienced recent nasal septal ulcers, recurrent [[epistaxis]], [[nasal surgery]] or trauma, until healing.<ref name="nih.gov"/> In pregnancy, recommended doses of intranasal corticosteroids are safe and effective.<ref name="auto"/> |
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==References== |
== References == |
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{{Reflist|2}} |
{{Reflist|2}} |
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{{Glucocorticoids}} |
{{Glucocorticoids}} |
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{{Glucocorticoidics}} |
{{Glucocorticoidics}} |
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[[Category:Corticosteroid cyclic ketals]] |
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[[Category:Diketones]] |
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[[Category:Diols]] |
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[[Category:Organofluorides]] |
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[[Category:Glucocorticoids]] |
[[Category:Glucocorticoids]] |
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⚫ | |||
{{respiratory-system-drug-stub}} |
Latest revision as of 23:16, 1 October 2024
Clinical data | |
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Trade names | Aerobid, Nasalide, Nasarel, others |
Other names | 6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione acetone cyclic 16,17-acetal |
AHFS/Drugs.com | Monograph |
MedlinePlus | a681048 |
Routes of administration | Inhaled |
ATC code | |
Pharmacokinetic data | |
Protein binding | 40% after inhalation |
Elimination half-life | 1.8 hours |
Identifiers | |
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CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.020.177 |
Chemical and physical data | |
Formula | C24H31FO6 |
Molar mass | 434.504 g·mol−1 |
3D model (JSmol) | |
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(what is this?) (verify) |
Flunisolide (marketed as AeroBid among others) is a corticosteroid often prescribed as a treatment for allergic rhinitis.[1] Intranasal corticosteroids are the most effective medication for controlling symptoms.[2]
Flunisolide's principal mechanism of action is to activate glucocorticoid receptors, indicating an anti-inflammatory action. The effects of topical corticosteroids are not immediate and must be used for at least a few days for noticeable relief. As-needed use is less effective than regular recommended use.[2] Flunisolide should not be used for nasal infections. It should not be continued if symptoms are not relieved after regular use for over two to three weeks.[3]
Patented in 1958 and approved for medical use in 1978,[4] it is on the World Health Organization's List of Essential Medicines.[5]
Side effects
[edit]Temporary nose and throat dryness, irritation, bleeding, or unpleasant taste or smell may occur.[6] Nasal septum perforation has been rarely reported.[2] Rare but localized infections of the nose and pharynx with Candida albicans have also been reported. Its long-term use may raise the chances of cataracts or glaucoma.[7]
Flunisolide nasal spray is absorbed into the circulatory system (blood).[3] Corticosteroid nasal sprays may affect the hypothalamic-pituitary-adrenal axis function in humans.[7] After obtaining the desired clinical effect, the maintenance dose should be reduced to the smallest amount required to control the symptoms. The amount can be as low as one spray in each nostril daily. Utilizing the minimum effective dose reduces possibility of side effects.[7] Recommended amounts of intranasal corticosteroids are generally not associated with systemic side effects.
Corticosteroids inhibit wound healing, so corticosteroid nasal sprays should be used cautiously in patients who have experienced recent nasal septal ulcers, recurrent epistaxis, nasal surgery or trauma, until healing.[3] In pregnancy, recommended doses of intranasal corticosteroids are safe and effective.[2]
References
[edit]- ^ "Flunisolide". DrugBank.
- ^ a b c d Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, et al. (August 2008). "The diagnosis and management of rhinitis: an updated practice parameter". The Journal of Allergy and Clinical Immunology. 122 (2 Suppl): S1-84. doi:10.1016/j.jaci.2008.06.003. PMID 18662584.
- ^ a b c "Flunisolide Nasal Solution". DailyMed. U.S. National Library of Medicine.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 486. ISBN 9783527607495.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ^ "FLUNISOLIDE - NASAL (Nasalide, Nasarel) side effects, medical uses, and drug interactions". MedicineNet.
- ^ a b c "Nasalide (Flunisolide (Nasal Spray)) Drug Information: Clinical Pharmacology - Prescribing Information". RxList.