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{{Short description|Method of allocation in organ transplantation}}
'''ABO-incompatible (ABOi) transplantation''' is a method of allocation in [[organ transplantation]] that permits more efficient use of available organs regardless of [[ABO blood group system|ABO blood type]], which would otherwise be unavailable due to [[Transplant rejection#Hyperacute rejection|hyperacute rejection]].<ref name="west2006">West, L. J., Karamlou, T., Dipchand, A. I., Pollock-Barziv, S. M., Coles, J. G., & McCrindle, B. W. (2006). Impact on outcomes after listing and transplantation, of a strategy to accept ABO blood group-incompatible donor hearts for neonates and infants. The Journal of Thoracic and Cardiovascular Surgery, 131(2), 455–461. doi:10.1016/j.jtcvs.2005.09.048</ref><ref name="schmoeckel2005">Schmoeckel, M., Däbritz, S. H., Kozlik-Feldmann, R., Wittmann, G., Christ, F., Kowalski, C., et al. (2005). Successful ABO-incompatible heart transplantation in two infants. Transplant International, 18(10), 1210–1214. doi:10.1111/j.1432-2277.2005.00181.x</ref> Primarily in use in infants and young toddlers, research is ongoing to allow for increased use of this capability in adult transplants. Normal ABO-compatibility rules may be observed for all recipients.<ref name="schmoeckel2005" /> This means that anyone may receive a transplant of a type-O organ, and consequently, type-O recipients are one of the biggest beneficiaries of ABO-incompatible transplants.<ref name="schmoeckel2005" /> While focus has been on infant heart transplants, the principles generally apply to other forms of solid organ transplantation.<ref name="west2009">ABO Incompatible Heart Transplantation in Young Infants. (2009, July 30). ABO Incompatible Heart Transplantation in Young Infants. American Society of Transplantation. Retrieved from http://www.myast.org/podcasts/abo-incompatible-heart-transplantation-young-infants</ref>
'''ABO-incompatible (ABOi) transplantation''' is a method of allocation in [[organ transplantation]] that permits more efficient use of available organs regardless of [[ABO blood group system|ABO blood type]], which would otherwise be unavailable due to [[Transplant rejection#Hyperacute rejection|hyperacute rejection]].<ref name="west2006">West, L. J., Karamlou, T., Dipchand, A. I., Pollock-Barziv, S. M., Coles, J. G., & McCrindle, B. W. (2006). Impact on outcomes after listing and transplantation, of a strategy to accept ABO blood group-incompatible donor hearts for neonates and infants. The Journal of Thoracic and Cardiovascular Surgery, 131(2), 455–461. {{doi|10.1016/j.jtcvs.2005.09.048}}</ref><ref name="schmoeckel2005">Schmoeckel, M., Däbritz, S. H., Kozlik-Feldmann, R., Wittmann, G., Christ, F., Kowalski, C., et al. (2005). Successful ABO-incompatible heart transplantation in two infants. Transplant International, 18(10), 1210–1214. {{doi|10.1111/j.1432-2277.2005.00181.x}}</ref> Primarily in use in infants and young toddlers, research is ongoing to allow for increased use of this capability in adult transplants. Normal ABO-compatibility rules may be observed for all recipients.<ref name="schmoeckel2005" /> This means that anyone may receive a transplant of a type-O organ, and consequently, type-O recipients are one of the biggest beneficiaries of ABO-incompatible transplants.<ref name="schmoeckel2005" /> While focus has been on infant heart transplants, the principles generally apply to other forms of solid organ transplantation.<ref name="west2009">ABO Incompatible Heart Transplantation in Young Infants. (2009, July 30). ABO Incompatible Heart Transplantation in Young Infants. American Society of Transplantation. Retrieved from {{cite web|url=http://www.myast.org/podcasts/abo-incompatible-heart-transplantation-young-infants |title=ABO Incompatible Heart Transplantation in Young Infants &#124; American Society of Transplantation (AST) |accessdate=December 25, 2013 |url-status=dead |archiveurl=https://web.archive.org/web/20131220072758/http://www.myast.org/podcasts/abo-incompatible-heart-transplantation-young-infants |archivedate=December 20, 2013 }}</ref>

__TOC__


== ABO-incompatible transplantation in young children ==
== ABO-incompatible transplantation in young children ==


Because very young children (generally under 12 months, but often as old as 24 months<ref name="west2009" />) do not have a well-developed [[immune system]],<ref name="west2001">West, L. J., Pollock-Barziv, S. M., Dipchand, A. I., Lee, K.-J. J., Cardella, C. J., Benson, L. N., et al. (2001). ABO-incompatible (ABOi) heart transplantation in infants. New England Journal of Medicine, 344(11), 793–800. doi:10.1056/NEJM200103153441102</ref> it is possible for them to receive organs from otherwise incompatible donors. This is known as ABO-incompatible (ABOi) transplantation. During the initial study period of 1996-2001, allowing for ABOi [[heart transplant]]ation reduced infant mortality from 58% to 7%.<ref name="west2001" /> Graft survival and patient mortality is approximately the same between ABOi and ABOc recipients.<ref name="west2006" /><ref name="saczkowski2010">Saczkowski, R., Dacey, C., & Bernier, P.-L. (2010). Does ABO-incompatible and ABO-compatible neonatal heart transplant have equivalent survival? Interactive cardiovascular and thoracic surgery, 10(6), 1026–1033. doi:10.1510/icvts.2009.229757</ref><ref name="stewart2009">Stewart, Z. A., Locke, J. E., Montgomery, R. A., Singer, A. L., Cameron, A. M., & Segev, D. L. (2009). ABO-incompatible deceased donor liver transplantation in the United States: a national registry analysis. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 15(8), 883–893. doi:10.1002/lt.21723</ref> This was found to not only allow for better allocation of organs among donors, but improved graft ischemia by reducing the time required to transport organs to prospective patients.<ref name="west2006" /> Children are more likely to be listed for ABOi transplantation if they are [[United Network for Organ Sharing|UNOS]] status 1A (i.e. the most critical category.)<ref name="almond2010">Almond, C. S. D., Gauvreau, K., Thiagarajan, R. R., Piercey, G. E., Blume, E. D., Smoot, L. B., et al. (2010). Impact of ABO-Incompatible Listing on Wait-List Outcomes Among Infants Listed for Heart Transplantation in the United States: A Propensity Analysis. Circulation, 121(17), 1926–1933. doi:10.1161/CIRCULATIONAHA.109.885756</ref>
Because very young children (generally under 12 months, but often as old as 24 months<ref name="west2009" />) do not have a well-developed [[immune system]],<ref name="west2001">West, L. J., Pollock-Barziv, S. M., Dipchand, A. I., Lee, K.-J. J., Cardella, C. J., Benson, L. N., et al. (2001). ABO-incompatible (ABOi) heart transplantation in infants. New England Journal of Medicine, 344(11), 793–800. {{doi|10.1056/NEJM200103153441102}}</ref> it is possible for them to receive organs from otherwise incompatible donors. This is known as ABO-incompatible (ABOi) transplantation. During the initial study period of 1996–2001, allowing for ABOi [[heart transplant]]ation reduced infant mortality from 58% to 7%.<ref name="west2001" /> Graft survival and patient mortality is approximately the same between ABOi and ABOc recipients.<ref name="west2006" /><ref name="saczkowski2010">Saczkowski, R., Dacey, C., & Bernier, P.-L. (2010). Does ABO-incompatible and ABO-compatible neonatal heart transplant have equivalent survival? Interactive cardiovascular and thoracic surgery, 10(6), 1026–1033. {{doi|10.1510/icvts.2009.229757}}</ref><ref name="stewart2009">Stewart, Z. A., Locke, J. E., Montgomery, R. A., Singer, A. L., Cameron, A. M., & Segev, D. L. (2009). ABO-incompatible deceased donor liver transplantation in the United States: a national registry analysis. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 15(8), 883–893. {{doi|10.1002/lt.21723}}</ref> This was found to not only allow for better allocation of organs among donors, but improved graft ischemia by reducing the time required to transport organs to prospective patients.<ref name="west2006" /> Children are more likely to be listed for ABOi transplantation if they are [[United Network for Organ Sharing|UNOS]] status 1A (i.e. the most critical category.)<ref name="almond2010">Almond, C. S. D., Gauvreau, K., Thiagarajan, R. R., Piercey, G. E., Blume, E. D., Smoot, L. B., et al. (2010). Impact of ABO-Incompatible Listing on Wait-List Outcomes Among Infants Listed for Heart Transplantation in the United States: A Propensity Analysis. Circulation, 121(17), 1926–1933. {{doi|10.1161/CIRCULATIONAHA.109.885756}}</ref>


The most important factors are that the recipient not have produced [[isohemagglutinin]]s, and that they have low levels of T cell-independent [[antigen]]s.<ref name="west2001" /><ref name="burch2004">Burch, M., & Aurora, P. (2004). Current status of paediatric heart, lung, and heart-lung transplantation. Archives of disease in childhood, 89(4), 386–389.</ref> Studies have shown that the period under which a recipient may undergo ABOi transplantation may be prolonged by exposure to nonself A and B antigens.<ref name="fan2004">Fan, X., Ang, A., Pollock-Barziv, S. M., Dipchand, A. I., Ruiz, P., Wilson, G., et al. (2004). Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation. Nature medicine, 10(11), 1227–1233. doi:10.1038/nm1126</ref> Furthermore, should the recipient (for example, type B-positive with a type AB-positive graft) require eventual retransplantation, the recipient may be medically capable of receiving a new organ of either blood type.<ref name="west2009" /><ref name="urschel2013" />
The most important factors are that the recipient not have produced [[isohemagglutinin]]s, and that they have low levels of T cell-independent [[antigen]]s.<ref name="west2001" /><ref name="burch2004">Burch, M., & Aurora, P. (2004). Current status of paediatric heart, lung, and heart-lung transplantation. Archives of Disease in Childhood, 89(4), 386–389.</ref> Studies have shown that the period under which a recipient may undergo ABOi transplantation may be prolonged by exposure to nonself A and B antigens.<ref name="fan2004">Fan, X., Ang, A., Pollock-Barziv, S. M., Dipchand, A. I., Ruiz, P., Wilson, G., et al. (2004). Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation. Nature medicine, 10(11), 1227–1233. {{doi|10.1038/nm1126}}</ref> Furthermore, should the recipient (for example, type B-positive with a type AB-positive graft) require eventual retransplantation, the recipient may be medically capable of receiving a new organ of either blood type.<ref name="west2009" /><ref name="urschel2013" />


In the United States, UNOS policies allow for ABOi transplantation in children under two years of age if isohemagglutinin titers are 1:4 or below,<ref name="urschel2013">Urschel, S., Larsen, I. M., Kirk, R., Flett, J., Burch, M., Shaw, N. L., et al. (2013). ABO-incompatible heart transplantation in early childhood An international multicenter study of clinical experiences and limits. The Journal of Heart and Lung Transplantation, 32(3), 285–292. doi:10.1016/j.healun.2012.11.022</ref><ref name="unos_policy_3.7">United Network for Organ Sharing. (2013, January 31). OPTN Policy 3.7 - Allocation of Thoracic Organs. Retrieved from http://optn.transplant.hrsa.gov/policiesAndBylaws/policies.asp</ref> and if there is no matching ABO-compatible (ABOc) recipient,<ref name="almond2010"/><ref name="urschel2013" /><ref name="unos_policy_3.7" /> UNOS is considering relaxation of the infant heart transplantation policy such that ABO matching is not a consideration for children under 1 year of age, and if titers are 1:16 or below for children up to age 2.<ref name="unos_prop321">Ghimire, V. (2013, March 7). Proposal to Change Pediatric Heart Allocation Policy. United Network for Organ Sharing. Retrieved from http://optn.transplant.hrsa.gov/PublicComment/pubcommentPropSub_321.pdf</ref> Canadian centers have a heart transplantation policy matching the proposed policy in the United States.<ref name="west2009" />
In the United States, UNOS policies allow for ABOi transplantation in children under two years of age if isohemagglutinin titers are 1:4 or below,<ref name="urschel2013">Urschel, S., Larsen, I. M., Kirk, R., Flett, J., Burch, M., Shaw, N. L., et al. (2013). ABO-incompatible heart transplantation in early childhood An international multicenter study of clinical experiences and limits. The Journal of Heart and Lung Transplantation, 32(3), 285–292. {{doi|10.1016/j.healun.2012.11.022}}</ref><ref name="unos_policy_3.7">United Network for Organ Sharing. (2013, January 31). OPTN Policy 3.7 - Allocation of Thoracic Organs. Retrieved from {{cite web|url=http://optn.transplant.hrsa.gov/policiesAndBylaws/policies.asp |title=OPTN: Organ Procurement and Transplantation Network |accessdate=December 25, 2013 |url-status=dead |archiveurl=https://web.archive.org/web/20131207035214/http://optn.transplant.hrsa.gov/policiesAndBylaws/policies.asp |archivedate=December 7, 2013 }}</ref> and if there is no matching ABO-compatible (ABOc) recipient,<ref name="almond2010"/><ref name="urschel2013" /><ref name="unos_policy_3.7" /> UNOS is considering relaxation of the infant heart transplantation policy such that ABO matching is not a consideration for children under 1 year of age, and if titers are 1:16 or below for children up to age 2.<ref name="unos_prop321">Ghimire, V. (2013, March 7). Proposal to Change Pediatric Heart Allocation Policy. United Network for Organ Sharing. Retrieved from {{cite web|url=http://optn.transplant.hrsa.gov/PublicComment/pubcommentPropSub_321.pdf |title=Archived copy |accessdate=2013-05-05 |url-status=dead |archiveurl=https://web.archive.org/web/20140708162539/http://optn.transplant.hrsa.gov/PublicComment/pubcommentPropSub_321.pdf |archivedate=2014-07-08 }}</ref> Canadian centers have a heart transplantation policy matching the proposed policy in the United States.<ref name="west2009" />


Intentional ABOi heart transplantation in infants was conceived in the 1960s by [[Adrian Kantrowitz]],<ref name="mcrae2007">McRae, Donald (2007-08-07). Every Second Counts: The Race to Transplant the First Human Heart (p. 25). Penguin Group. Kindle Edition.</ref> with clinical evidence first being shown by [[Leonard L. Bailey]]'s team in the mid-1980s, which he termed "[[immune privilege|immunologic privilege]]."<ref name="bailey1988">Bailey, L. L., Assaad, A. N., Trimm, R. F., Nehlsen-Cannarella, S. L., Kanakriyeh, M. S., Haas, G. S., & Jacobson, J. G. (1988). Orthotopic transplantation during early infancy as therapy for incurable congenital heart disease. Annals of Surgery, 208(3), 279.</ref> It was first conducted in practice in 1996 by a team led by Dr. Lori J. West<ref name="klein2011">Klein, A. A., Lewis, C. J., & Madsen, J. C. (2011). Organ Transplantation: A Clinical Guide. p.116. Cambridge University Press.</ref> at the [[Hospital for Sick Children]] in [[Toronto]], and published in a seminal 2001 study.<ref name="everitt2009">Everitt, M. D., Donaldson, A. E., Casper, T. C., Stehlik, J., Hawkins, J. A., Tani, L. Y., et al. (2009). Effect of ABO-incompatible listing on infant heart transplant waitlist outcomes: analysis of the United Network for Organ Sharing (UNOS) database. The Journal of Heart and Lung Transplantation, 28(12), 1254–1260. doi:10.1016/j.healun.2009.06.024</ref> In the United Kingdom, policy since 2000 is that ABOi heart transplantation is ''de rigueur'' for infants, and is considered for children under age 4, though proactive measures are often taken to lower titer levels.<ref name="roche2007">Roche, S. L., Burch, M., O'Sullivan, J., Wallis, J., Parry, G., Kirk, R., et al. (2007). Multicenter Experience of ABO-Incompatible Pediatric Cardiac Transplantation. American Journal of Transplantation, 0(0), 071117175452003–??? doi:10.1111/j.1600-6143.2007.02040.x</ref>
Intentional ABOi heart transplantation in infants was conceived in the 1960s by [[Adrian Kantrowitz]],<ref name="mcrae2007">McRae, Donald (2007-08-07). Every Second Counts: The Race to Transplant the First Human Heart (p. 25). Penguin Group. Kindle Edition.</ref> with clinical evidence first being shown by [[Leonard L. Bailey]]'s team in the mid-1980s, which he termed "[[immune privilege|immunologic privilege]]."<ref name="bailey1988">Bailey, L. L., Assaad, A. N., Trimm, R. F., Nehlsen-Cannarella, S. L., Kanakriyeh, M. S., Haas, G. S., & Jacobson, J. G. (1988). Orthotopic transplantation during early infancy as therapy for incurable congenital heart disease. Annals of Surgery, 208(3), 279.</ref> It was first conducted in practice in 1996 by a team led by Dr. Lori J. West<ref name="klein2011">Klein, A. A., Lewis, C. J., & Madsen, J. C. (2011). Organ Transplantation: A Clinical Guide. p.116. Cambridge University Press.</ref> at the [[The Hospital for Sick Children, Toronto|Hospital for Sick Children]] in [[Toronto]], and published in a seminal 2001 study.<ref name="everitt2009">Everitt, M. D., Donaldson, A. E., Casper, T. C., Stehlik, J., Hawkins, J. A., Tani, L. Y., et al. (2009). Effect of ABO-incompatible listing on infant heart transplant waitlist outcomes: analysis of the United Network for Organ Sharing (UNOS) database. The Journal of Heart and Lung Transplantation, 28(12), 1254–1260. {{doi|10.1016/j.healun.2009.06.024}}</ref> In the United Kingdom, policy since 2000 is that ABOi heart transplantation is ''de rigueur'' for infants, and is considered for children under age 4, though proactive measures are often taken to lower titer levels.<ref name="roche2007">Roche, S. L., Burch, M., O'Sullivan, J., Wallis, J., Parry, G., Kirk, R., et al. (2007). Multicenter Experience of ABO-Incompatible Pediatric Cardiac Transplantation. American Journal of Transplantation, 0(0), 071117175452003–??? {{doi|10.1111/j.1600-6143.2007.02040.x}}</ref>


== ABO-incompatible transplantation in older children and adults ==
== ABO-incompatible transplantation in older children and adults ==
Limited success has been achieved in ABOi heart transplantation in adults,<ref name="tyden2012">Tydén, G., Hagerman, I., Grinnemo, K.-H., Svenarud, P., van der Linden, J., Kumlien, G., & Wernerson, A. (2012). Intentional ABO-incompatible heart transplantation: a case report of 2 adult patients. The Journal of Heart and Lung Transplantation, 31(12), 1307–1310. doi:10.1016/j.healun.2012.09.011</ref> though this requires that the adult recipients have low levels of anti-A or anti-B antibodies.<ref name="tyden2012" /> Some organs are more conducive to adult ABOi transplant than others, such as [[liver transplantation|liver]]<ref name="stewart2009" /> and [[kidney transplantation|kidney]].<ref name="schmoeckel2005" /><ref name="montgomery2012">Montgomery, J. R., Berger, J. C., Warren, D. S., James, N. T., Montgomery, R. A., & Segev, D. L. (2012). Outcomes of ABO-incompatible kidney transplantation in the United States. Transplantation, 93(6), 603–609. doi:10.1097/TP.0b013e318245b2af</ref> Adults are significantly likely to suffer from hyperacute rejection,<ref name="west2006" /> [[thrombosis]], or [[death]], but could be considered to be an acceptable risk if the alternative is otherwise death.<ref name="stewart2009" /> In the case of ABOi kidney transplantation, aggressive antibody removal is required, along with supplemental medication, with the resulting condition being termed "accommodation."<ref name="urschel2013" /> While such recipients are more likely to require re-transplantation early on, long-term graft survival is similar to recipients who receive ABOc kidneys.<ref name="montgomery2012" />
Limited success has been achieved in ABOi heart transplantation in adults,<ref name="tyden2012">Tydén, G., Hagerman, I., Grinnemo, K.-H., Svenarud, P., van der Linden, J., Kumlien, G., & Wernerson, A. (2012). Intentional ABO-incompatible heart transplantation: a case report of 2 adult patients. The Journal of Heart and Lung Transplantation, 31(12), 1307–1310. {{doi|10.1016/j.healun.2012.09.011}}</ref> though this requires that the adult recipients have low levels of anti-A or anti-B antibodies.<ref name="tyden2012" /> Some organs are more conducive to adult ABOi transplant than others, such as the [[liver transplantation|liver]]<ref name="stewart2009" /> and [[kidney transplantation|kidneys]].<ref name="schmoeckel2005" /><ref name="montgomery2012">Montgomery, J. R., Berger, J. C., Warren, D. S., James, N. T., Montgomery, R. A., & Segev, D. L. (2012). Outcomes of ABO-incompatible kidney transplantation in the United States. Transplantation, 93(6), 603–609. {{doi|10.1097/TP.0b013e318245b2af}}</ref> Adults are significantly likely to suffer from hyperacute rejection,<ref name="west2006" /> [[thrombosis]], or [[death]], but could be considered to be an acceptable risk if the alternative is death.<ref name="stewart2009" /> In the case of ABOi renal transplantation, aggressive antibody removal is required, along with supplemental medication, with the resulting condition being termed "accommodation."<ref name="urschel2013" /> While such recipients are more likely to require re-transplantation early on, long-term graft survival is similar to recipients who receive ABOc kidneys.<ref name="montgomery2012" />


== References ==
== References ==
{{Research help|Med}}
{{reflist}}
{{reflist}}


Latest revision as of 12:05, 2 October 2024

ABO-incompatible (ABOi) transplantation is a method of allocation in organ transplantation that permits more efficient use of available organs regardless of ABO blood type, which would otherwise be unavailable due to hyperacute rejection.[1][2] Primarily in use in infants and young toddlers, research is ongoing to allow for increased use of this capability in adult transplants. Normal ABO-compatibility rules may be observed for all recipients.[2] This means that anyone may receive a transplant of a type-O organ, and consequently, type-O recipients are one of the biggest beneficiaries of ABO-incompatible transplants.[2] While focus has been on infant heart transplants, the principles generally apply to other forms of solid organ transplantation.[3]

ABO-incompatible transplantation in young children

[edit]

Because very young children (generally under 12 months, but often as old as 24 months[3]) do not have a well-developed immune system,[4] it is possible for them to receive organs from otherwise incompatible donors. This is known as ABO-incompatible (ABOi) transplantation. During the initial study period of 1996–2001, allowing for ABOi heart transplantation reduced infant mortality from 58% to 7%.[4] Graft survival and patient mortality is approximately the same between ABOi and ABOc recipients.[1][5][6] This was found to not only allow for better allocation of organs among donors, but improved graft ischemia by reducing the time required to transport organs to prospective patients.[1] Children are more likely to be listed for ABOi transplantation if they are UNOS status 1A (i.e. the most critical category.)[7]

The most important factors are that the recipient not have produced isohemagglutinins, and that they have low levels of T cell-independent antigens.[4][8] Studies have shown that the period under which a recipient may undergo ABOi transplantation may be prolonged by exposure to nonself A and B antigens.[9] Furthermore, should the recipient (for example, type B-positive with a type AB-positive graft) require eventual retransplantation, the recipient may be medically capable of receiving a new organ of either blood type.[3][10]

In the United States, UNOS policies allow for ABOi transplantation in children under two years of age if isohemagglutinin titers are 1:4 or below,[10][11] and if there is no matching ABO-compatible (ABOc) recipient,[7][10][11] UNOS is considering relaxation of the infant heart transplantation policy such that ABO matching is not a consideration for children under 1 year of age, and if titers are 1:16 or below for children up to age 2.[12] Canadian centers have a heart transplantation policy matching the proposed policy in the United States.[3]

Intentional ABOi heart transplantation in infants was conceived in the 1960s by Adrian Kantrowitz,[13] with clinical evidence first being shown by Leonard L. Bailey's team in the mid-1980s, which he termed "immunologic privilege."[14] It was first conducted in practice in 1996 by a team led by Dr. Lori J. West[15] at the Hospital for Sick Children in Toronto, and published in a seminal 2001 study.[16] In the United Kingdom, policy since 2000 is that ABOi heart transplantation is de rigueur for infants, and is considered for children under age 4, though proactive measures are often taken to lower titer levels.[17]

ABO-incompatible transplantation in older children and adults

[edit]

Limited success has been achieved in ABOi heart transplantation in adults,[18] though this requires that the adult recipients have low levels of anti-A or anti-B antibodies.[18] Some organs are more conducive to adult ABOi transplant than others, such as the liver[6] and kidneys.[2][19] Adults are significantly likely to suffer from hyperacute rejection,[1] thrombosis, or death, but could be considered to be an acceptable risk if the alternative is death.[6] In the case of ABOi renal transplantation, aggressive antibody removal is required, along with supplemental medication, with the resulting condition being termed "accommodation."[10] While such recipients are more likely to require re-transplantation early on, long-term graft survival is similar to recipients who receive ABOc kidneys.[19]

References

[edit]
  1. ^ a b c d West, L. J., Karamlou, T., Dipchand, A. I., Pollock-Barziv, S. M., Coles, J. G., & McCrindle, B. W. (2006). Impact on outcomes after listing and transplantation, of a strategy to accept ABO blood group-incompatible donor hearts for neonates and infants. The Journal of Thoracic and Cardiovascular Surgery, 131(2), 455–461. doi:10.1016/j.jtcvs.2005.09.048
  2. ^ a b c d Schmoeckel, M., Däbritz, S. H., Kozlik-Feldmann, R., Wittmann, G., Christ, F., Kowalski, C., et al. (2005). Successful ABO-incompatible heart transplantation in two infants. Transplant International, 18(10), 1210–1214. doi:10.1111/j.1432-2277.2005.00181.x
  3. ^ a b c d ABO Incompatible Heart Transplantation in Young Infants. (2009, July 30). ABO Incompatible Heart Transplantation in Young Infants. American Society of Transplantation. Retrieved from "ABO Incompatible Heart Transplantation in Young Infants | American Society of Transplantation (AST)". Archived from the original on December 20, 2013. Retrieved December 25, 2013.
  4. ^ a b c West, L. J., Pollock-Barziv, S. M., Dipchand, A. I., Lee, K.-J. J., Cardella, C. J., Benson, L. N., et al. (2001). ABO-incompatible (ABOi) heart transplantation in infants. New England Journal of Medicine, 344(11), 793–800. doi:10.1056/NEJM200103153441102
  5. ^ Saczkowski, R., Dacey, C., & Bernier, P.-L. (2010). Does ABO-incompatible and ABO-compatible neonatal heart transplant have equivalent survival? Interactive cardiovascular and thoracic surgery, 10(6), 1026–1033. doi:10.1510/icvts.2009.229757
  6. ^ a b c Stewart, Z. A., Locke, J. E., Montgomery, R. A., Singer, A. L., Cameron, A. M., & Segev, D. L. (2009). ABO-incompatible deceased donor liver transplantation in the United States: a national registry analysis. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 15(8), 883–893. doi:10.1002/lt.21723
  7. ^ a b Almond, C. S. D., Gauvreau, K., Thiagarajan, R. R., Piercey, G. E., Blume, E. D., Smoot, L. B., et al. (2010). Impact of ABO-Incompatible Listing on Wait-List Outcomes Among Infants Listed for Heart Transplantation in the United States: A Propensity Analysis. Circulation, 121(17), 1926–1933. doi:10.1161/CIRCULATIONAHA.109.885756
  8. ^ Burch, M., & Aurora, P. (2004). Current status of paediatric heart, lung, and heart-lung transplantation. Archives of Disease in Childhood, 89(4), 386–389.
  9. ^ Fan, X., Ang, A., Pollock-Barziv, S. M., Dipchand, A. I., Ruiz, P., Wilson, G., et al. (2004). Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation. Nature medicine, 10(11), 1227–1233. doi:10.1038/nm1126
  10. ^ a b c d Urschel, S., Larsen, I. M., Kirk, R., Flett, J., Burch, M., Shaw, N. L., et al. (2013). ABO-incompatible heart transplantation in early childhood An international multicenter study of clinical experiences and limits. The Journal of Heart and Lung Transplantation, 32(3), 285–292. doi:10.1016/j.healun.2012.11.022
  11. ^ a b United Network for Organ Sharing. (2013, January 31). OPTN Policy 3.7 - Allocation of Thoracic Organs. Retrieved from "OPTN: Organ Procurement and Transplantation Network". Archived from the original on December 7, 2013. Retrieved December 25, 2013.
  12. ^ Ghimire, V. (2013, March 7). Proposal to Change Pediatric Heart Allocation Policy. United Network for Organ Sharing. Retrieved from "Archived copy" (PDF). Archived from the original (PDF) on 2014-07-08. Retrieved 2013-05-05.{{cite web}}: CS1 maint: archived copy as title (link)
  13. ^ McRae, Donald (2007-08-07). Every Second Counts: The Race to Transplant the First Human Heart (p. 25). Penguin Group. Kindle Edition.
  14. ^ Bailey, L. L., Assaad, A. N., Trimm, R. F., Nehlsen-Cannarella, S. L., Kanakriyeh, M. S., Haas, G. S., & Jacobson, J. G. (1988). Orthotopic transplantation during early infancy as therapy for incurable congenital heart disease. Annals of Surgery, 208(3), 279.
  15. ^ Klein, A. A., Lewis, C. J., & Madsen, J. C. (2011). Organ Transplantation: A Clinical Guide. p.116. Cambridge University Press.
  16. ^ Everitt, M. D., Donaldson, A. E., Casper, T. C., Stehlik, J., Hawkins, J. A., Tani, L. Y., et al. (2009). Effect of ABO-incompatible listing on infant heart transplant waitlist outcomes: analysis of the United Network for Organ Sharing (UNOS) database. The Journal of Heart and Lung Transplantation, 28(12), 1254–1260. doi:10.1016/j.healun.2009.06.024
  17. ^ Roche, S. L., Burch, M., O'Sullivan, J., Wallis, J., Parry, G., Kirk, R., et al. (2007). Multicenter Experience of ABO-Incompatible Pediatric Cardiac Transplantation. American Journal of Transplantation, 0(0), 071117175452003–??? doi:10.1111/j.1600-6143.2007.02040.x
  18. ^ a b Tydén, G., Hagerman, I., Grinnemo, K.-H., Svenarud, P., van der Linden, J., Kumlien, G., & Wernerson, A. (2012). Intentional ABO-incompatible heart transplantation: a case report of 2 adult patients. The Journal of Heart and Lung Transplantation, 31(12), 1307–1310. doi:10.1016/j.healun.2012.09.011
  19. ^ a b Montgomery, J. R., Berger, J. C., Warren, D. S., James, N. T., Montgomery, R. A., & Segev, D. L. (2012). Outcomes of ABO-incompatible kidney transplantation in the United States. Transplantation, 93(6), 603–609. doi:10.1097/TP.0b013e318245b2af
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