Csaba Pal: Difference between revisions

Csaba Pal
Csaba Pal
	Pal in 2009
Born	March 27, 1975 (age 49); Budapest, Hungary
Education	Eötvös Loránd Tudományegyetem (PhD)
Alma mater	Hungarian Academy of Sciences (D.Sc.)
Occupation	Biologist
Employer	Biological Research Centre
Awards	Ignaz Lieben Award (2009); Szent-Györgyi Talents Award (2014); Bolyai Prize (2015); Member of the Academia Europaea(2016); EMBO Member (2017); Member of the Federation of European Microbiological Societies(FEMS);
Website	http://group.szbk.u-szeged.hu/sysbiol/pal-csaba-lab-index.html

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Csaba Pal (Hungarian: Pál [ˈpaːl] Csaba [ˈt͡ʃɒbɒ]; born March 27, 1975)^[6]^[7] is a Hungarian biologist at the Biological Research Centre (BRC)^[8] in Szeged Hungary. His laboratory is part of the Synthetic and Systems Biology Unit at BRC.^[9]^[10] His research is at the interface of evolution, antibiotic resistance and genome engineering^[11]^[5] and has published over 80 scientific publications in these areas.^[12]^[13]

Education

Csaba Pal completed his master's in biology at Eötvös Loránd University, Budapest, in 1998.^[7]^[14] Four years later he was awarded a Doctor of Philosophy degree from the Eötvös Loránd University, Budapest in 2002.^[7]^[14] In 2018 he received a Doctor of Science degree from the Hungarian Academy of Sciences.^[7] Csaba Pal spent several years abroad with scholarships. He had the opportunity to research in Bath,^[15] Oxford, Heidelberg and Italy.^[7]^[14] Prior to his return to Hungary in 2008, he worked as a visiting scientist at the University of Trento.^[7]^[14] In 2023 Csaba Pál become a Corresponding member of the Hungarian Academy of Sciences.

Career and research

Csaba Pal works on fundamental and applied problems in the evolution of genome networks and antibiotic resistance.^[11] To achieve these goals, he develops methods in systems biology, computational metabolic modelling and genome engineering.

Genome evolution

In 2001, Csaba Pal and colleagues demonstrated that highly expressed genes in yeast evolve slowly.^[16] Later, they argued that evolutionary rate of a protein is predominantly influenced by its expression level rather than functional importance. This research has contributed to a paradigmatic shift in the field of protein evolution.^[17]^[18] Balazs Papp, Csaba Pal, and Laurence Hurst studied molecular mechanisms underlying dosage sensitivity.^[19] They specifically tested what is now known as the dosage balance hypothesis.^[20] The hypothesis offers a synthesis on seemingly unrelated problems such as the evolution of dominance, gene duplicability and co-evolution of protein complex subunits. In 2007, Pal and colleagues demonstrated that antagonistic co-evolution with parasites has a large impact on the evolution of bacterial mutation rate.^[21] This paper showed how biotic interactions shape mutation rate evolution.

More recently, the Pal lab explored the consequences of compensatory adaptation on gene content evolution.^[22] It is well known that while core cellular processes are generally conserved during evolution, the underlying genes differ somewhat between related species. They demonstrated that gene loss initiates adaptive genomic changes that rapidly restores fitness, but this process has substantial pleiotropic effects on cellular physiology and evolvability upon environmental change.^[22]

Network evolution

The Pal lab has also contributed to the nascent field of evolutionary systems biology.^[23] Their research focused on understanding the extent to which evolution is predictable at the molecular level. Using genome-scale metabolic network modelling combined with experimental tools they studied key issues in evolution, such as mutational robustness,^[24] horizontal gene transfer,^[25] genome reduction,^[26] epistasis,^[27]^[28] promiscuous enzyme reactions,^[29] and complex adaptations.^[30]

Antibiotic resistance

Csaba Pal's laboratory currently studies the problem of antibiotic resistance. By combining laboratory evolution, genome sequencing, and functional analysis, they charted the map of evolutionary trade-offs between antibiotics. They found that multidrug resistance mutations in bacteria simultaneously enhance sensitivity to many other unrelated drugs (collateral sensitivity), and explored the underlying molecular mechanisms.^[31]

Genome engineering

Finally, the Pal lab is an advocate of the emerging field of evolutionary genome engineering.^[32]^[33] Genome engineering enables the modification of specific genomic locations in a directed and combinatorial manner, and allow studying central evolutionary issues in which natural genetic variation is limited or biased. However, current tools have been optimized for a few laboratory model strains, lead to the accumulation of numerous undesired, off-target modifications, and demand extensive modification of the host genome prior to large-scale editing. The Pal laboratory presented a simple, all-in-one solution.^[34]^[35] The method is unique as it allows systematic comparison of mutational effects and epistasis across a wide range of bacterial species.

Awards and honours

Csaba Pal received several domestic and international awards, including the Ignaz Lieben Award (2009),^[36]^{[circular reference]}^[37] Szent-Györgyi Talents Award (2014),^[1] and the Bolyai Prize (2015).^[38]^[39]^[40]^[41] In 2016, Csaba Pal became member of Academia Europaea.^[2] In 2017 he was selected as EMBO (European Molecular Biology Organization) member.^[3]^[4] and in 2018, became a member of the FEMS. (Federation of European Microbiological Societies)^[5] In 2021 Csaba received and Academic Award^[42] and in 2023 he was elected as Corresponding member of the Hungarian Academy of Sciences^[43]^[44]

References

^ ^a ^b "Szent-Györgyi Talents Award". www.nobel-szeged.hu. Archived from the original on 29 January 2020. Retrieved 29 January 2020.
^ ^a ^b "Academy of Europe: P%C 3%A 1 l Csaba". www.ae-info.org. Retrieved 28 January 2020.
^ ^a ^b Jukic, Igor. "EMBO welcomes 65 new members". EMBO. Archived from the original on 19 June 2017. Retrieved 16 June 2017.
^ ^a ^b "Find people in the EMBO Communities". people.embo.org. Retrieved 28 January 2020.
^ ^a ^b ^c "FEMS Expert: Dr Csaba Pal". FEMS. Retrieved 29 January 2020.
^ "BRC Csaba PÁL D.Sc". www.brc.hu. Retrieved 29 January 2020.^{[permanent dead link‍]}
^ ^a ^b ^c ^d ^e ^f "BRC Csaba PÁL CV" (PDF). Archived from the original (PDF) on 29 January 2020. Retrieved 29 January 2020.
^ "BRC". www.brc.hu. Retrieved 28 January 2020.
^ "BRC Synthetic and Systems Biology Unit". www.brc.hu. Archived from the original on 28 January 2020. Retrieved 29 January 2020.
^ "Csaba Pál Laboratory". group.szbk.u-szeged.hu. Retrieved 28 January 2020.
^ ^a ^b "New members greeted in Heidelberg". EMBO. 19 December 2018. Retrieved 19 December 2018.
^ "Magyar Tudományos Művek Tára". m2.mtmt.hu. Retrieved 31 January 2020.
^ "Csaba Pal - Google Scholar Citations". scholar.google.hu. Retrieved 31 January 2020.
^ ^a ^b ^c ^d "Academy of Europe: CV". www.ae-info.org. Retrieved 29 January 2020.
^ "Students and post-docs past and present". people.bath.ac.uk. Retrieved 28 January 2020.
^ Hurst, Laurence D.; Papp, Balázs; Pál, Csaba (June 2001). "Highly Expressed Genes in Yeast Evolve Slowly". Genetics. 158 (2): 927–931. doi:10.1093/genetics/158.2.927. PMC 1461684. PMID 11430355.
^ Zhang, Jianzhi; Yang, Jian-Rong (2015). "Determinants of the rate of protein sequence evolution". Nature Reviews Genetics. 16 (7): 409–420. doi:10.1038/nrg3950. PMC 4523088. PMID 26055156.
^ Koonin, E. V. (2011). "Are there laws of genome evolution?". PLOS Computational Biology. 7 (8): e1002173. arXiv:1108.3589. Bibcode:2011PLSCB...7E2173K. doi:10.1371/journal.pcbi.1002173. PMC 3161903. PMID 21901087.
^ Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (July 2003). "Dosage sensitivity and the evolution of gene families in yeast". Nature. 424 (6945): 194–197. Bibcode:2003Natur.424..194P. doi:10.1038/nature01771. ISSN 1476-4687. PMID 12853957. S2CID 4382441. Retrieved 10 July 2003.
^ Birchler, J. A.; Veitia, R. A. (20 August 2012). "Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplines". Proceedings of the National Academy of Sciences. 109 (37): 14746–14753. doi:10.1073/pnas.1207726109. ISSN 0027-8424. PMC 3443177. PMID 22908297.
^ Pal, Csaba; Maciá, María D.; Oliver, Antonio; Schachar, Ira; Buckling, Angus (December 2007). "Coevolution with viruses drives the evolution of bacterial mutation rates". Nature. 450 (7172): 1079–1081. Bibcode:2007Natur.450.1079P. doi:10.1038/nature06350. ISSN 1476-4687. PMID 18059461. S2CID 4373536. Retrieved 2 December 2007.
^ ^a ^b Szamecz, Béla; Boross, Gábor; Kalapis, Dorottya; Kovács, Károly; Fekete, Gergely; Farkas, Zoltán; Lázár, Viktória; Hrtyan, Mónika; Kemmeren, Patrick; Groot Koerkamp, Marian J. A.; Rutkai, Edit; Holstege, Frank C. P.; Papp, Balázs; Pál, Csaba (2014). "The Genomic Landscape of Compensatory Evolution". PLOS Biology. 12 (8): e1001935. doi:10.1371/journal.pbio.1001935. PMC 4144845. PMID 25157590.
^ Papp, Balázs; Notebaart, Richard A.; Pál, Csaba (September 2011). "Systems-biology approaches for predicting genomic evolution". Nature Reviews Genetics. 12 (9): 591–602. doi:10.1038/nrg3033. ISSN 1471-0064. PMID 21808261. S2CID 13965868. Retrieved 2 August 2011.
^ Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (June 2004). "Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast". Nature. 429 (6992): 661–664. Bibcode:2004Natur.429..661P. doi:10.1038/nature02636. ISSN 1476-4687. PMID 15190353. S2CID 492849. Retrieved 10 June 2004.
^ Pál, Csaba; Papp, Balázs; Lercher, Martin J. (December 2005). "Adaptive evolution of bacterial metabolic networks by horizontal gene transfer". Nature Genetics. 37 (12): 1372–1375. doi:10.1038/ng1686. ISSN 1546-1718. PMID 16311593. S2CID 14611750. Retrieved 20 November 2005.
^ Pál, Csaba; Papp, Balázs; Lercher, Martin J.; Csermely, Péter; Oliver, Stephen G.; Hurst, Laurence D. (March 2006). "Chance and necessity in the evolution of minimal metabolic networks". Nature. 440 (7084): 667–670. Bibcode:2006Natur.440..667P. doi:10.1038/nature04568. ISSN 1476-4687. PMID 16572170. S2CID 4424895. Retrieved 30 March 2006.
^ Harrison, Richard; Papp, Balázs; Pál, Csaba; Oliver, Stephen G.; Delneri, Daniela (13 February 2007). "Plasticity of genetic interactions in metabolic networks of yeast". Proceedings of the National Academy of Sciences. 104 (7): 2307–2312. Bibcode:2007PNAS..104.2307H. doi:10.1073/pnas.0607153104. ISSN 0027-8424. PMC 1892960. PMID 17284612.
^ Szappanos, Balázs; Kovács, Károly; Szamecz, Béla; Honti, Frantisek; Costanzo, Michael; Baryshnikova, Anastasia; Gelius-Dietrich, Gabriel; Lercher, Martin J.; Jelasity, Márk; Myers, Chad L.; Andrews, Brenda J.; Boone, Charles; Oliver, Stephen G.; Pál, Csaba; Papp, Balázs (July 2011). "An integrated approach to characterize genetic interaction networks in yeast metabolism". Nature Genetics. 43 (7): 656–662. doi:10.1038/ng.846. ISSN 1546-1718. PMC 3125439. PMID 21623372.
^ Notebaart, Richard A.; Szappanos, Balázs; Kintses, Bálint; Pál, Ferenc; Györkei, Ádám; Bogos, Balázs; Lázár, Viktória; Spohn, Réka; Csörgő, Bálint; Wagner, Allon; Ruppin, Eytan; Pál, Csaba; Papp, Balázs (12 August 2014). "Network-level architecture and the evolutionary potential of underground metabolism". Proceedings of the National Academy of Sciences. 111 (32): 11762–11767. Bibcode:2014PNAS..11111762N. doi:10.1073/pnas.1406102111. ISSN 0027-8424. PMC 4136603. PMID 25071190.
^ Szappanos, Balázs; Fritzemeier, Jonathan; Csörgő, Bálint; Lázár, Viktória; Lu, Xiaowen; Fekete, Gergely; Bálint, Balázs; Herczeg, Róbert; Nagy, István; Notebaart, Richard A.; Lercher, Martin J.; Pál, Csaba; Papp, Balázs (20 May 2016). "Adaptive evolution of complex innovations through stepwise metabolic niche expansion". Nature Communications. 7 (1): 11607. Bibcode:2016NatCo...711607S. doi:10.1038/ncomms11607. ISSN 2041-1723. PMC 5411730. PMID 27197754.
^ Lázár, Viktória; Pal Singh, Gajinder; Spohn, Réka; Nagy, István; Horváth, Balázs; Hrtyan, Mónika; Busa-Fekete, Róbert; Bogos, Balázs; Méhi, Orsolya; Csörgő, Bálint; Pósfai, György; Fekete, Gergely; Szappanos, Balázs; Kégl, Balázs; Papp, Balázs; Pál, Csaba (2013). "Bacterial evolution of antibiotic hypersensitivity". Molecular Systems Biology. 9: 700. doi:10.1038/msb.2013.57. PMC 3817406. PMID 24169403.
^ Bokor, Dóra (11 June 2018). "Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance". MTA.hu (in Hungarian). Retrieved 11 June 2018.
^ Pál, Csaba; Papp, Balázs; Pósfai, György (28 May 2014). "The dawn of evolutionary genome engineering". Nature Reviews Genetics. 15 (7): 504–512. doi:10.1038/nrg3746. ISSN 1471-0056. PMID 24866756. S2CID 6854503. Retrieved 28 May 2014.
^ Nyerges, Ákos; Csörgő, Bálint; Nagy, István; Latinovics, Dóra; Szamecz, Béla; Pósfai, György; Pál, Csaba (1 April 2014). "Conditional DNA repair mutants enable highly precise genome engineering". Nucleic Acids Research. 42 (8): e62. doi:10.1093/nar/gku105. ISSN 0305-1048. PMC 4005651. PMID 24500200.
^ Nyerges, Ákos; Csörgő, Bálint; Nagy, István; Bálint, Balázs; Bihari, Péter; Lázár, Viktória; Apjok, Gábor; Umenhoffer, Kinga; Bogos, Balázs; Pósfai, György; Pál, Csaba (11 February 2016). "A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species". Proceedings of the National Academy of Sciences. 113 (9): 2502–2507. Bibcode:2016PNAS..113.2502N. doi:10.1073/pnas.1520040113. ISSN 0027-8424. PMC 4780621. PMID 26884157.
^ "Lieben Prize". Wikipedia. 17 January 2020. Retrieved 29 January 2020.
^ "Csaba Pal". stipendien.oeaw.ac.at. Archived from the original on 10 April 2019. Retrieved 17 November 2008.
^ "Pál Csaba biológus a Bolyai-díjas 2015-ben". Hivatalos weboldalra költözött a Bolyai-díj. Retrieved 17 May 2015.
^ "Bolyai-díj – 2015". National Geographic (in Hungarian). 18 May 2015. Retrieved 18 May 2015.
^ "Biologist Csaba Pál is awarded this year's Bolyai Prize". www.t-systems.hu. Retrieved 18 May 2015.
^ "Pál Csaba biológus kapta az idei Bolyai-díjat". hirado.hu (in Hungarian). Retrieved 17 May 2015.
^ "Akadémiai elismerések a közgyűlésen". 3 May 2021.
^ "Eseménynaptár".
^ "Antibiotikumok és ellenálló baktériumok – Pál Csaba székfoglaló előadása (2023.03.14.)". YouTube. 3 April 2023.

[Szent-Györgyi_Talents_Award-1] "Szent-Györgyi Talents Award". www.nobel-szeged.hu. Archived from the original on 29 January 2020. Retrieved 29 January 2020.

[ae-info.org-2] "Academy of Europe: P%C 3%A 1 l Csaba". www.ae-info.org. Retrieved 28 January 2020.

[EMBO_welcomes_65_new_members-3] Jukic, Igor. "EMBO welcomes 65 new members". EMBO. Archived from the original on 19 June 2017. Retrieved 16 June 2017.

[people.embo.org-4] "Find people in the EMBO Communities". people.embo.org. Retrieved 28 January 2020.

[FEMS-5] "FEMS Expert: Dr Csaba Pal". FEMS. Retrieved 29 January 2020.

[6] "BRC Csaba PÁL D.Sc". www.brc.hu. Retrieved 29 January 2020.^{[permanent dead link‍]}

[BRCCV-7] ^ ^a ^b ^c ^d ^e ^f "BRC Csaba PÁL CV" (PDF). Archived from the original (PDF) on 29 January 2020. Retrieved 29 January 2020.

[8] "BRC". www.brc.hu. Retrieved 28 January 2020.

[9] "BRC Synthetic and Systems Biology Unit". www.brc.hu. Archived from the original on 28 January 2020. Retrieved 29 January 2020.

[10] "Csaba Pál Laboratory". group.szbk.u-szeged.hu. Retrieved 28 January 2020.

[Heidelberg-11] "New members greeted in Heidelberg". EMBO. 19 December 2018. Retrieved 19 December 2018.

[12] "Magyar Tudományos Művek Tára". m2.mtmt.hu. Retrieved 31 January 2020.

[13] "Csaba Pal - Google Scholar Citations". scholar.google.hu. Retrieved 31 January 2020.

[AcademiaEuropaeaCV-14] "Academy of Europe: CV". www.ae-info.org. Retrieved 29 January 2020.

[15] "Students and post-docs past and present". people.bath.ac.uk. Retrieved 28 January 2020.

[16] Hurst, Laurence D.; Papp, Balázs; Pál, Csaba (June 2001). "Highly Expressed Genes in Yeast Evolve Slowly". Genetics. 158 (2): 927–931. doi:10.1093/genetics/158.2.927. PMC 1461684. PMID 11430355.

[17] Zhang, Jianzhi; Yang, Jian-Rong (2015). "Determinants of the rate of protein sequence evolution". Nature Reviews Genetics. 16 (7): 409–420. doi:10.1038/nrg3950. PMC 4523088. PMID 26055156.

[18] Koonin, E. V. (2011). "Are there laws of genome evolution?". PLOS Computational Biology. 7 (8): e1002173. arXiv:1108.3589. Bibcode:2011PLSCB...7E2173K. doi:10.1371/journal.pcbi.1002173. PMC 3161903. PMID 21901087.

[19] Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (July 2003). "Dosage sensitivity and the evolution of gene families in yeast". Nature. 424 (6945): 194–197. Bibcode:2003Natur.424..194P. doi:10.1038/nature01771. ISSN 1476-4687. PMID 12853957. S2CID 4382441. Retrieved 10 July 2003.

[20] Birchler, J. A.; Veitia, R. A. (20 August 2012). "Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplines". Proceedings of the National Academy of Sciences. 109 (37): 14746–14753. doi:10.1073/pnas.1207726109. ISSN 0027-8424. PMC 3443177. PMID 22908297.

[21] Pal, Csaba; Maciá, María D.; Oliver, Antonio; Schachar, Ira; Buckling, Angus (December 2007). "Coevolution with viruses drives the evolution of bacterial mutation rates". Nature. 450 (7172): 1079–1081. Bibcode:2007Natur.450.1079P. doi:10.1038/nature06350. ISSN 1476-4687. PMID 18059461. S2CID 4373536. Retrieved 2 December 2007.

[ReferenceA-22] Szamecz, Béla; Boross, Gábor; Kalapis, Dorottya; Kovács, Károly; Fekete, Gergely; Farkas, Zoltán; Lázár, Viktória; Hrtyan, Mónika; Kemmeren, Patrick; Groot Koerkamp, Marian J. A.; Rutkai, Edit; Holstege, Frank C. P.; Papp, Balázs; Pál, Csaba (2014). "The Genomic Landscape of Compensatory Evolution". PLOS Biology. 12 (8): e1001935. doi:10.1371/journal.pbio.1001935. PMC 4144845. PMID 25157590.

[23] Papp, Balázs; Notebaart, Richard A.; Pál, Csaba (September 2011). "Systems-biology approaches for predicting genomic evolution". Nature Reviews Genetics. 12 (9): 591–602. doi:10.1038/nrg3033. ISSN 1471-0064. PMID 21808261. S2CID 13965868. Retrieved 2 August 2011.

[24] Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (June 2004). "Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast". Nature. 429 (6992): 661–664. Bibcode:2004Natur.429..661P. doi:10.1038/nature02636. ISSN 1476-4687. PMID 15190353. S2CID 492849. Retrieved 10 June 2004.

[25] Pál, Csaba; Papp, Balázs; Lercher, Martin J. (December 2005). "Adaptive evolution of bacterial metabolic networks by horizontal gene transfer". Nature Genetics. 37 (12): 1372–1375. doi:10.1038/ng1686. ISSN 1546-1718. PMID 16311593. S2CID 14611750. Retrieved 20 November 2005.

[26] Pál, Csaba; Papp, Balázs; Lercher, Martin J.; Csermely, Péter; Oliver, Stephen G.; Hurst, Laurence D. (March 2006). "Chance and necessity in the evolution of minimal metabolic networks". Nature. 440 (7084): 667–670. Bibcode:2006Natur.440..667P. doi:10.1038/nature04568. ISSN 1476-4687. PMID 16572170. S2CID 4424895. Retrieved 30 March 2006.

[27] Harrison, Richard; Papp, Balázs; Pál, Csaba; Oliver, Stephen G.; Delneri, Daniela (13 February 2007). "Plasticity of genetic interactions in metabolic networks of yeast". Proceedings of the National Academy of Sciences. 104 (7): 2307–2312. Bibcode:2007PNAS..104.2307H. doi:10.1073/pnas.0607153104. ISSN 0027-8424. PMC 1892960. PMID 17284612.

[28] Szappanos, Balázs; Kovács, Károly; Szamecz, Béla; Honti, Frantisek; Costanzo, Michael; Baryshnikova, Anastasia; Gelius-Dietrich, Gabriel; Lercher, Martin J.; Jelasity, Márk; Myers, Chad L.; Andrews, Brenda J.; Boone, Charles; Oliver, Stephen G.; Pál, Csaba; Papp, Balázs (July 2011). "An integrated approach to characterize genetic interaction networks in yeast metabolism". Nature Genetics. 43 (7): 656–662. doi:10.1038/ng.846. ISSN 1546-1718. PMC 3125439. PMID 21623372.

[29] Notebaart, Richard A.; Szappanos, Balázs; Kintses, Bálint; Pál, Ferenc; Györkei, Ádám; Bogos, Balázs; Lázár, Viktória; Spohn, Réka; Csörgő, Bálint; Wagner, Allon; Ruppin, Eytan; Pál, Csaba; Papp, Balázs (12 August 2014). "Network-level architecture and the evolutionary potential of underground metabolism". Proceedings of the National Academy of Sciences. 111 (32): 11762–11767. Bibcode:2014PNAS..11111762N. doi:10.1073/pnas.1406102111. ISSN 0027-8424. PMC 4136603. PMID 25071190.

[30] Szappanos, Balázs; Fritzemeier, Jonathan; Csörgő, Bálint; Lázár, Viktória; Lu, Xiaowen; Fekete, Gergely; Bálint, Balázs; Herczeg, Róbert; Nagy, István; Notebaart, Richard A.; Lercher, Martin J.; Pál, Csaba; Papp, Balázs (20 May 2016). "Adaptive evolution of complex innovations through stepwise metabolic niche expansion". Nature Communications. 7 (1): 11607. Bibcode:2016NatCo...711607S. doi:10.1038/ncomms11607. ISSN 2041-1723. PMC 5411730. PMID 27197754.

[31] Lázár, Viktória; Pal Singh, Gajinder; Spohn, Réka; Nagy, István; Horváth, Balázs; Hrtyan, Mónika; Busa-Fekete, Róbert; Bogos, Balázs; Méhi, Orsolya; Csörgő, Bálint; Pósfai, György; Fekete, Gergely; Szappanos, Balázs; Kégl, Balázs; Papp, Balázs; Pál, Csaba (2013). "Bacterial evolution of antibiotic hypersensitivity". Molecular Systems Biology. 9: 700. doi:10.1038/msb.2013.57. PMC 3817406. PMID 24169403.

[32] Bokor, Dóra (11 June 2018). "Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance". MTA.hu (in Hungarian). Retrieved 11 June 2018.

[33] Pál, Csaba; Papp, Balázs; Pósfai, György (28 May 2014). "The dawn of evolutionary genome engineering". Nature Reviews Genetics. 15 (7): 504–512. doi:10.1038/nrg3746. ISSN 1471-0056. PMID 24866756. S2CID 6854503. Retrieved 28 May 2014.

[34] Nyerges, Ákos; Csörgő, Bálint; Nagy, István; Latinovics, Dóra; Szamecz, Béla; Pósfai, György; Pál, Csaba (1 April 2014). "Conditional DNA repair mutants enable highly precise genome engineering". Nucleic Acids Research. 42 (8): e62. doi:10.1093/nar/gku105. ISSN 0305-1048. PMC 4005651. PMID 24500200.

[35] Nyerges, Ákos; Csörgő, Bálint; Nagy, István; Bálint, Balázs; Bihari, Péter; Lázár, Viktória; Apjok, Gábor; Umenhoffer, Kinga; Bogos, Balázs; Pósfai, György; Pál, Csaba (11 February 2016). "A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species". Proceedings of the National Academy of Sciences. 113 (9): 2502–2507. Bibcode:2016PNAS..113.2502N. doi:10.1073/pnas.1520040113. ISSN 0027-8424. PMC 4780621. PMID 26884157.

[36] "Lieben Prize". Wikipedia. 17 January 2020. Retrieved 29 January 2020.

[37] "Csaba Pal". stipendien.oeaw.ac.at. Archived from the original on 10 April 2019. Retrieved 17 November 2008.

[38] "Pál Csaba biológus a Bolyai-díjas 2015-ben". Hivatalos weboldalra költözött a Bolyai-díj. Retrieved 17 May 2015.

[39] "Bolyai-díj – 2015". National Geographic (in Hungarian). 18 May 2015. Retrieved 18 May 2015.

[40] "Biologist Csaba Pál is awarded this year's Bolyai Prize". www.t-systems.hu. Retrieved 18 May 2015.

[41] "Pál Csaba biológus kapta az idei Bolyai-díjat". hirado.hu (in Hungarian). Retrieved 17 May 2015.

[42] "Akadémiai elismerések a közgyűlésen". 3 May 2021.

[43] "Eseménynaptár".

[44] "Antibiotikumok és ellenálló baktériumok – Pál Csaba székfoglaló előadása (2023.03.14.)". YouTube. 3 April 2023.

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@@ Line 1: / Line 1: @@
 {{short description|Hungarian biologist (born 1975)}}
-{{Orphan|date=April 2020}}
 {{Infobox person
 | honorific_prefix   =
 | name               = Csaba Pal
 | honorific_suffix   =
-| image              = [[File:Csaba Pal receiving The Bolyai Price.jpg|thumb|]]
+| image              = Pál Csaba.jpg
+| caption            = Pal in 2009
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-| caption            = Csaba Pal receiving the [[:hu:Bolyai János alkotói díj|Bolyai Prize]] in 2015
 | native_name        =
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-| birth_date         = March 27,1975 (age 42)
+| birth_date         = {{birth date and age|March 27, 1975}}
-| birth_place        = [[Budapest]], [[Hungary]]
+| birth_place        = [[Budapest]], Hungary
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-| nationality        = Hungarian
+| nationality        =
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@@ Line 35: / Line 34: @@
 | education          = [[Eötvös Loránd Tudományegyetem]] (PhD)
 | alma_mater         = [[Hungarian Academy of Sciences]] (D.Sc.)
-| occupation         =[[Biologist]]
+| occupation         = [[Biologist]]
 | years_active       =
 | era                =
 | employer           = [[Biological Research Centre]]
 | organization       =
-| agent = <!-- Discouraged in most cases, specifically when promotional, and requiring a reliable source -->
+| agent              = <!-- Discouraged in most cases, specifically when promotional, and requiring a reliable source -->
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-| awards             = {{Plainlist|
+| awards             = {{Plainlist
-<!--only those awards notable enough for a dedicated wikipedia article-->
+|<!--only those awards notable enough for a dedicated wikipedia article-->
 *[[Lieben Prize|Ignaz Lieben Award]] (2009)
-*Szent-Györgyi Talents Award (2014)<ref>{{cite web |title=Szent-Györgyi Talents Award |url=http://www.nobel-szeged.hu/eng/index.php/szegedi-orv-kut-joevojeert-alap/szent-gyoergyi-talents-award |website=www.nobel-szeged.hu |accessdate=29 January 2020}}</ref>
+*Szent-Györgyi Talents Award (2014)<ref name="Szent-Györgyi Talents Award">{{cite web |title=Szent-Györgyi Talents Award |url=http://www.nobel-szeged.hu/eng/index.php/szegedi-orv-kut-joevojeert-alap/szent-gyoergyi-talents-award |website=www.nobel-szeged.hu |accessdate=29 January 2020 |archive-date=29 January 2020 |archive-url=https://web.archive.org/web/20200129202856/http://www.nobel-szeged.hu/eng/index.php/szegedi-orv-kut-joevojeert-alap/szent-gyoergyi-talents-award |url-status=dead }}</ref>
 *[[:hu:Bolyai János alkotói díj|Bolyai Prize]] (2015)
-*Member of the [[Academia Europaea]](2016)<ref>{{cite web |title=Academy of Europe: P%C 3%A 1 l Csaba |url=https://www.ae-info.org/ae/Member/P%C3%A1l_Csaba |website=www.ae-info.org |accessdate=28 January 2020}}</ref>
+*Member of the [[Academia Europaea]](2016)<ref name="ae-info.org">{{cite web |title=Academy of Europe: P%C 3%A 1 l Csaba |url=https://www.ae-info.org/ae/Member/P%C3%A1l_Csaba |website=www.ae-info.org |accessdate=28 January 2020}}</ref>
-* [[EMBO Member]] (2017)<ref>{{cite web |last1=Jukic |first1=Igor |title=EMBO welcomes 65 new members |url=https://www.embo.org/news/press-releases/2017/embo-welcomes-65-new-members |website=EMBO |accessdate=16 June 2017 |language=en-gb}}</ref><ref>{{cite web |title=Find people in the EMBO Communities |url=https://people.embo.org/profile/csaba-pal |website=people.embo.org |accessdate=28 January 2020}}</ref>
+* [[EMBO Member]] (2017)<ref name="EMBO welcomes 65 new members">{{cite web |last1=Jukic |first1=Igor |title=EMBO welcomes 65 new members |url=https://www.embo.org/news/press-releases/2017/embo-welcomes-65-new-members |website=EMBO |accessdate=16 June 2017 |language=en-gb |archive-date=19 June 2017 |archive-url=https://web.archive.org/web/20170619111823/http://embo.org/news/press-releases/2017/embo-welcomes-65-new-members |url-status=dead }}</ref><ref name="people.embo.org">{{cite web |title=Find people in the EMBO Communities |url=https://people.embo.org/profile/csaba-pal |website=people.embo.org |accessdate=28 January 2020}}</ref>
 *Member of the [[Federation of European Microbiological Societies]](FEMS)<ref name=FEMS>{{cite web |title=FEMS Expert: Dr Csaba Pal |url=https://fems-microbiology.org/network/leading_opinion_in_science/eam-members/fems-expert-dr-csaba-pal/ |website=FEMS |accessdate=29 January 2020}}</ref>}}
+| website        = http://group.szbk.u-szeged.hu/sysbiol/pal-csaba-lab-index.html
+| module         =
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-| website            = http://group.szbk.u-szeged.hu/sysbiol/pal-csaba-lab-index.html
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 }}
-'''Csaba Pal''' (Hungarian: Pál [ˈpaːl] Csaba [ˈt͡ʃɒbɒ], born March 27, 1975)<ref>{{cite web |title=BRC Csaba PÁL D.Sc. |url=http://www.brc.hu/personal_page.php?id=bk_p%C3%A1cs |website=www.brc.hu |accessdate=29 January 2020}}</ref><ref name=BRCCV>{{cite web |title=BRC Csaba PÁL CV  |url=http://www.brc.hu/file/cv/biochem_pal_csaba_en.pdf |accessdate=29 January 2020}}</ref> is a Hungarian biologist at the [[Biological Research Centre]] (BRC)<ref>{{cite web |title=BRC |url=http://www.brc.hu |website=www.brc.hu |accessdate=28 January 2020}}</ref> in [[Szeged]] [[Hungary]]. His laboratory is part of the [[Synthetic biology|Synthetic]] and [[Systems Biology]] Unit at BRC.<ref>{{cite web |title=BRC Synthetic and Systems Biology Unit  |url=http://www.brc.hu/biochem_synthetic_systems_biology_unit.php |website=www.brc.hu |accessdate=29 January 2020}}</ref><ref>{{cite web |title=Csaba Pál Laboratory |url=http://group.szbk.u-szeged.hu/sysbiol/pal-csaba-lab-index.html |website=group.szbk.u-szeged.hu |accessdate=28 January 2020}}</ref> His research is at the interface of [[evolution]], [[antibiotic resistance]] and [[genome engineering]]<ref name=Heidelberg>{{cite web |title=New members greeted in Heidelberg |url=https://www.embo.org/news/articles/2018/new-members-greeted-in-heidelberg |website=EMBO |accessdate=19 December 2018 |language=en-gb}}</ref><ref name=FEMS>{{cite web |title=FEMS Expert: Dr Csaba Pal |url=https://fems-microbiology.org/network/leading_opinion_in_science/eam-members/fems-expert-dr-csaba-pal/ |website=FEMS |accessdate=29 January 2020}}</ref> and has published over 70 scientific publications in these areas.<ref>{{cite web |title=Magyar Tudományos Művek Tára |url=https://m2.mtmt.hu/gui2/?type=authors&mode=browse&sel=10027825&view=pubTable |website=m2.mtmt.hu |accessdate=31 January 2020}}</ref><ref>{{cite web |title=Csaba Pal - Google Scholar Citations |url=https://scholar.google.hu/citations?user=9VUsiHMAAAAJ&hl=en |website=scholar.google.hu |accessdate=31 January 2020}}</ref>
+'''Csaba Pal''' (Hungarian: Pál [ˈpaːl] Csaba [ˈt͡ʃɒbɒ]; born March 27, 1975)<ref>{{cite web |title=BRC Csaba PÁL D.Sc. |url=http://www.brc.hu/personal_page.php?id=bk_p%C3%A1cs |website=www.brc.hu |accessdate=29 January 2020 }}{{Dead link|date=December 2023 |bot=InternetArchiveBot |fix-attempted=yes }}</ref><ref name=BRCCV>{{cite web  |title=BRC Csaba PÁL CV  |url=http://www.brc.hu/file/cv/biochem_pal_csaba_en.pdf  |accessdate=29 January 2020  |archive-date=29 January 2020  |archive-url=https://web.archive.org/web/20200129181350/http://www.brc.hu/file/cv/biochem_pal_csaba_en.pdf  |url-status=dead  }}</ref> is a Hungarian biologist at the [[Biological Research Centre]] (BRC)<ref>{{cite web |title=BRC |url=http://www.brc.hu |website=www.brc.hu |accessdate=28 January 2020}}</ref> in [[Szeged]] [[Hungary]]. His laboratory is part of the [[Synthetic biology|Synthetic]] and [[Systems Biology]] Unit at BRC.<ref>{{cite web |title=BRC Synthetic and Systems Biology Unit |url=http://www.brc.hu/biochem_synthetic_systems_biology_unit.php |website=www.brc.hu |accessdate=29 January 2020 |archive-date=28 January 2020 |archive-url=https://web.archive.org/web/20200128210634/http://www.brc.hu/biochem_synthetic_systems_biology_unit.php |url-status=dead }}</ref><ref>{{cite web |title=Csaba Pál Laboratory |url=http://group.szbk.u-szeged.hu/sysbiol/pal-csaba-lab-index.html |website=group.szbk.u-szeged.hu |accessdate=28 January 2020}}</ref> His research is at the interface of [[evolution]], [[antibiotic resistance]] and [[genome engineering]]<ref name=Heidelberg>{{cite web |title=New members greeted in Heidelberg |url=https://www.embo.org/news/articles/2018/new-members-greeted-in-heidelberg |website=EMBO |date=19 December 2018 |accessdate=19 December 2018 |language=en-gb}}</ref><ref name=FEMS>{{cite web |title=FEMS Expert: Dr Csaba Pal |url=https://fems-microbiology.org/network/leading_opinion_in_science/eam-members/fems-expert-dr-csaba-pal/ |website=FEMS |accessdate=29 January 2020}}</ref> and has published over 80 scientific publications in these areas.<ref>{{cite web |title=Magyar Tudományos Művek Tára |url=https://m2.mtmt.hu/gui2/?type=authors&mode=browse&sel=10027825&view=pubTable |website=m2.mtmt.hu |accessdate=31 January 2020}}</ref><ref>{{cite web |title=Csaba Pal - Google Scholar Citations |url=https://scholar.google.hu/citations?user=9VUsiHMAAAAJ&hl=en |website=scholar.google.hu |accessdate=31 January 2020}}</ref>
 ==Education==
-Csaba Pal completed his [[Master's degree|Masters]] in Biology at [[Eötvös Loránd University]], [[Budapest]], in 1998.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV>{{cite web |title=Academy of Europe: CV |url=https://www.ae-info.org/ae/Member/P%C3%A1l_Csaba/CV |website=www.ae-info.org |accessdate=29 January 2020}}</ref> Four years later he was awarded a [[Doctor of Philosophy]] degree from the [[Eötvös Loránd University]], [[Budapest]] in 2002.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/> In 2018 he received a [[Doctor of Science]] degree from the [[Hungarian Academy of Sciences]].<ref name=BRCCV/>
+Csaba Pal completed his [[Master's degree|master's]] in biology at [[Eötvös Loránd University]], [[Budapest]], in 1998.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV>{{cite web |title=Academy of Europe: CV |url=https://www.ae-info.org/ae/Member/P%C3%A1l_Csaba/CV |website=www.ae-info.org |accessdate=29 January 2020}}</ref> Four years later he was awarded a [[Doctor of Philosophy]] degree from the [[Eötvös Loránd University]], [[Budapest]] in 2002.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/> In 2018 he received a [[Doctor of Science]] degree from the [[Hungarian Academy of Sciences]].<ref name=BRCCV/>
-Csaba Pal spent several years abroad with scholarships. He had the opportunity to research in [[Bath, Somerset|Bath]],<ref>{{cite web |title=Students and post-docs past and present |url=https://people.bath.ac.uk/bssldh/LaurenceDHurst/Lab_members.html |website=people.bath.ac.uk |accessdate=28 January 2020}}</ref> [[Oxford]], [[Heidelberg]] and [[Italy]].<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/> Prior to his return to Hungary in 2008, he worked as a visiting scientist at the [[University of Trento]].<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/>
+Csaba Pal spent several years abroad with scholarships. He had the opportunity to research in [[Bath, Somerset|Bath]],<ref>{{cite web |title=Students and post-docs past and present |url=https://people.bath.ac.uk/bssldh/LaurenceDHurst/Lab_members.html |website=people.bath.ac.uk |accessdate=28 January 2020}}</ref> [[Oxford]], [[Heidelberg]] and [[Italy]].<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/> Prior to his return to Hungary in 2008, he worked as a visiting scientist at the [[University of Trento]].<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/> In 2023 Csaba Pál become a [[Corresponding member]] of the [[Hungarian Academy of Sciences]].
 ==Career and research==
@@ Line 103: / Line 98: @@
 ==Genome evolution==
-In 2001, Csaba Pal and colleagues demonstrated that highly expressed genes in [[yeast]] evolve slowly.<ref>{{Cite journal | url=https://www.genetics.org/content/158/2/927.full |title = Highly Expressed Genes in Yeast Evolve Slowly|journal = Genetics|volume = 158|issue = 2|pages = 927–931|date = June 2001|last1 = Hurst|first1 = Laurence D.|last2 = Papp|first2 = Balázs|last3 = Pál|first3 = Csaba|pmid = 11430355|pmc = 1461684}}</ref> Later, they argued that [[Rate of evolution|evolutionary rate]] of a [[protein]] is predominantly influenced by its expression level rather than functional importance. This research has contributed to a paradigmatic shift in the field of [[Molecular evolution|protein evolution]].<ref>{{Cite journal | doi=10.1038/nrg3950| pmid=26055156| pmc=4523088| title=Determinants of the rate of protein sequence evolution| journal=Nature Reviews Genetics| volume=16| issue=7| pages=409–420| year=2015| last1=Zhang| first1=Jianzhi| last2=Yang| first2=Jian-Rong}}</ref><ref>{{Cite journal |pmid = 21901087|pmc = 3161903|year = 2011|last1 = Koonin|first1 = E. V.|title = Are there laws of genome evolution?|journal = PLOS Computational Biology|volume = 7|issue = 8|pages = e1002173|doi = 10.1371/journal.pcbi.1002173|bibcode = 2011PLSCB...7E2173K|arxiv = 1108.3589}}</ref> Balazs Papp, Csaba Pal, and [[Laurence Hurst]] studied molecular mechanisms underlying [[Gene dosage|dosage sensitivity]].<ref>{{cite journal |last1=Papp |first1=Balázs |last2=Pál |first2=Csaba |last3=Hurst |first3=Laurence D. |title=Dosage sensitivity and the evolution of gene families in yeast |journal=Nature |date=July 2003 |volume=424 |issue=6945 |pages=194–197 |doi=10.1038/nature01771 |pmid=12853957 |bibcode=2003Natur.424..194P |url=https://www.nature.com/articles/nature01771 |accessdate=10 July 2003 |language=en |issn=1476-4687}}</ref> They specifically tested what is now known as the dosage balance hypothesis.<ref>{{cite journal |last1=Birchler |first1=J. A. |last2=Veitia |first2=R. A. |title=Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplines |journal=Proceedings of the National Academy of Sciences |date=20 August 2012 |volume=109 |issue=37 |pages=14746–14753 |doi=10.1073/pnas.1207726109 |pmid=22908297 |url=https://www.pnas.org/content/109/37/14746 |accessdate=Sep 11, 2012 |language=en |issn=0027-8424}}</ref> The hypothesis offers a synthesis on seemingly unrelated problems such as the [[Dominance (genetics)|evolution of dominance]], gene duplicability and co-evolution of [[protein complex]][[Protein subunit| subunits]].  In 2007, Pal and colleagues demonstrated that antagonistic co-evolution with [[Parasitism|parasites]] has a large impact on the evolution of bacterial [[mutation rate]].<ref>{{cite journal |last1=Pal |first1=Csaba |last2=Maciá |first2=María D. |last3=Oliver |first3=Antonio |last4=Schachar |first4=Ira |last5=Buckling |first5=Angus |title=Coevolution with viruses drives the evolution of bacterial mutation rates |journal=Nature |date=December 2007 |volume=450 |issue=7172 |pages=1079–1081 |doi=10.1038/nature06350 |pmid=18059461 |bibcode=2007Natur.450.1079P |url=https://www.nature.com/articles/nature06350 |accessdate=2 December 2007 |language=en |issn=1476-4687}}</ref> This paper showed how biotic interactions shape [[mutation rate]] evolution.
+In 2001, Csaba Pal and colleagues demonstrated that highly expressed genes in [[yeast]] evolve slowly.<ref>{{Cite journal | url=https://www.genetics.org/content/158/2/927.full |title = Highly Expressed Genes in Yeast Evolve Slowly|journal = Genetics|volume = 158|issue = 2|pages = 927–931|date = June 2001|last1 = Hurst|first1 = Laurence D.|last2 = Papp|first2 = Balázs|last3 = Pál|first3 = Csaba|doi = 10.1093/genetics/158.2.927|pmid = 11430355|pmc = 1461684}}</ref> Later, they argued that [[Rate of evolution|evolutionary rate]] of a [[protein]] is predominantly influenced by its expression level rather than functional importance. This research has contributed to a paradigmatic shift in the field of [[Molecular evolution|protein evolution]].<ref>{{Cite journal | doi=10.1038/nrg3950| pmid=26055156| pmc=4523088| title=Determinants of the rate of protein sequence evolution| journal=Nature Reviews Genetics| volume=16| issue=7| pages=409–420| year=2015| last1=Zhang| first1=Jianzhi| last2=Yang| first2=Jian-Rong}}</ref><ref>{{Cite journal |pmid = 21901087|pmc = 3161903|year = 2011|last1 = Koonin|first1 = E. V.|title = Are there laws of genome evolution?|journal = PLOS Computational Biology|volume = 7|issue = 8|pages = e1002173|doi = 10.1371/journal.pcbi.1002173|bibcode = 2011PLSCB...7E2173K|arxiv = 1108.3589 | doi-access=free }}</ref> Balazs Papp, Csaba Pal, and [[Laurence Hurst]] studied molecular mechanisms underlying [[Gene dosage|dosage sensitivity]].<ref>{{cite journal |last1=Papp |first1=Balázs |last2=Pál |first2=Csaba |last3=Hurst |first3=Laurence D. |title=Dosage sensitivity and the evolution of gene families in yeast |journal=Nature |date=July 2003 |volume=424 |issue=6945 |pages=194–197 |doi=10.1038/nature01771 |pmid=12853957 |bibcode=2003Natur.424..194P |s2cid=4382441 |url=https://www.nature.com/articles/nature01771 |accessdate=10 July 2003 |language=en |issn=1476-4687}}</ref> They specifically tested what is now known as the dosage balance hypothesis.<ref>{{cite journal |last1=Birchler |first1=J. A. |last2=Veitia |first2=R. A. |title=Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplines |journal=Proceedings of the National Academy of Sciences |date=20 August 2012 |volume=109 |issue=37 |pages=14746–14753 |doi=10.1073/pnas.1207726109 |pmid=22908297 |pmc=3443177 |language=en |issn=0027-8424|doi-access=free }}</ref> The hypothesis offers a synthesis on seemingly unrelated problems such as the [[Dominance (genetics)|evolution of dominance]], gene duplicability and co-evolution of [[protein complex]][[Protein subunit|subunits]].  In 2007, Pal and colleagues demonstrated that antagonistic co-evolution with [[Parasitism|parasites]] has a large impact on the evolution of bacterial [[mutation rate]].<ref>{{cite journal |last1=Pal |first1=Csaba |last2=Maciá |first2=María D. |last3=Oliver |first3=Antonio |last4=Schachar |first4=Ira |last5=Buckling |first5=Angus |title=Coevolution with viruses drives the evolution of bacterial mutation rates |journal=Nature |date=December 2007 |volume=450 |issue=7172 |pages=1079–1081 |doi=10.1038/nature06350 |pmid=18059461 |bibcode=2007Natur.450.1079P |s2cid=4373536 |url=https://www.nature.com/articles/nature06350 |accessdate=2 December 2007 |language=en |issn=1476-4687}}</ref> This paper showed how biotic interactions shape [[mutation rate]] evolution.
-More recently, the Pal lab explored the consequences of compensatory [[adaptation]] on [[Human genome|gene content]] evolution.<ref>{{Cite journal |doi = 10.1371/journal.pbio.1001935|pmid = 25157590|pmc = 4144845|title = The Genomic Landscape of Compensatory Evolution|journal = PLOS Biology|volume = 12|issue = 8|pages = e1001935|year = 2014|last1 = Szamecz|first1 = Béla|last2 = Boross|first2 = Gábor|last3 = Kalapis|first3 = Dorottya|last4 = Kovács|first4 = Károly|last5 = Fekete|first5 = Gergely|last6 = Farkas|first6 = Zoltán|last7 = Lázár|first7 = Viktória|last8 = Hrtyan|first8 = Mónika|last9 = Kemmeren|first9 = Patrick|last10 = Groot Koerkamp|first10 = Marian J. A.|last11 = Rutkai|first11 = Edit|last12 = Holstege|first12 = Frank C. P.|last13 = Papp|first13 = Balázs|last14 = Pál|first14 = Csaba}}</ref> It is well known that while core cellular processes are generally conserved during [[evolution]], the underlying genes differ somewhat between related species. They demonstrated that [[gene loss]] initiates adaptive genomic changes that rapidly restores [[Fitness (biology)|fitness]], but this process has substantial [[Pleiotropy|pleiotropic]] effects on [[cellular physiology]] and evolvability upon [[environmental change]].<ref>{{Cite journal |doi = 10.1371/journal.pbio.1001935|pmid = 25157590|pmc = 4144845|title = The Genomic Landscape of Compensatory Evolution|journal = PLOS Biology|volume = 12|issue = 8|pages = e1001935|year = 2014|last1 = Szamecz|first1 = Béla|last2 = Boross|first2 = Gábor|last3 = Kalapis|first3 = Dorottya|last4 = Kovács|first4 = Károly|last5 = Fekete|first5 = Gergely|last6 = Farkas|first6 = Zoltán|last7 = Lázár|first7 = Viktória|last8 = Hrtyan|first8 = Mónika|last9 = Kemmeren|first9 = Patrick|last10 = Groot Koerkamp|first10 = Marian J. A.|last11 = Rutkai|first11 = Edit|last12 = Holstege|first12 = Frank C. P.|last13 = Papp|first13 = Balázs|last14 = Pál|first14 = Csaba}}</ref>
+More recently, the Pal lab explored the consequences of compensatory [[adaptation]] on [[Human genome|gene content]] evolution.<ref name="ReferenceA">{{Cite journal |doi = 10.1371/journal.pbio.1001935|pmid = 25157590|pmc = 4144845|title = The Genomic Landscape of Compensatory Evolution|journal = PLOS Biology|volume = 12|issue = 8|pages = e1001935|year = 2014|last1 = Szamecz|first1 = Béla|last2 = Boross|first2 = Gábor|last3 = Kalapis|first3 = Dorottya|last4 = Kovács|first4 = Károly|last5 = Fekete|first5 = Gergely|last6 = Farkas|first6 = Zoltán|last7 = Lázár|first7 = Viktória|last8 = Hrtyan|first8 = Mónika|last9 = Kemmeren|first9 = Patrick|last10 = Groot Koerkamp|first10 = Marian J. A.|last11 = Rutkai|first11 = Edit|last12 = Holstege|first12 = Frank C. P.|last13 = Papp|first13 = Balázs|last14 = Pál|first14 = Csaba | doi-access=free }}</ref> It is well known that while core cellular processes are generally conserved during [[evolution]], the underlying genes differ somewhat between related species. They demonstrated that [[gene loss]] initiates adaptive genomic changes that rapidly restores [[Fitness (biology)|fitness]], but this process has substantial [[Pleiotropy|pleiotropic]] effects on [[cellular physiology]] and evolvability upon [[environmental change]].<ref name="ReferenceA"/>
 ==Network evolution==
-The Pal lab has also contributed to the nascent field of evolutionary [[systems biology]].<ref>{{cite journal |last1=Papp |first1=Balázs |last2=Notebaart |first2=Richard A. |last3=Pál |first3=Csaba |title=Systems-biology approaches for predicting genomic evolution |journal=Nature Reviews Genetics |date=September 2011 |volume=12 |issue=9 |pages=591–602 |doi=10.1038/nrg3033 |pmid=21808261 |url=https://www.nature.com/articles/nrg3033 |accessdate=2 August 2011 |language=en |issn=1471-0064}}</ref> Their research focused on understanding the extent to which evolution is predictable at the molecular level. Using genome-scale [[metabolic network modelling]] combined with experimental tools they studied key issues in [[evolution]], such as mutational [[Robustness (evolution)|robustness]],<ref>{{cite journal |last1=Papp |first1=Balázs |last2=Pál |first2=Csaba |last3=Hurst |first3=Laurence D. |title=Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast |journal=Nature |date=June 2004 |volume=429 |issue=6992 |pages=661–664 |doi=10.1038/nature02636 |pmid=15190353 |bibcode=2004Natur.429..661P |url=https://www.nature.com/articles/nature02636 |accessdate=10 June 2004 |language=en |issn=1476-4687}}</ref> [[horizontal gene transfer]],<ref>{{cite journal |last1=Pál |first1=Csaba |last2=Papp |first2=Balázs |last3=Lercher |first3=Martin J. |title=Adaptive evolution of bacterial metabolic networks by horizontal gene transfer |journal=Nature Genetics |date=December 2005 |volume=37 |issue=12 |pages=1372–1375 |doi=10.1038/ng1686 |pmid=16311593 |url=https://www.nature.com/articles/ng1686 |accessdate=20 November 2005 |language=en |issn=1546-1718}}</ref> [[Genome size|genome reduction]],<ref>{{cite journal |last1=Pál |first1=Csaba |last2=Papp |first2=Balázs |last3=Lercher |first3=Martin J. |last4=Csermely |first4=Péter |last5=Oliver |first5=Stephen G. |last6=Hurst |first6=Laurence D. |title=Chance and necessity in the evolution of minimal metabolic networks |journal=Nature |date=March 2006 |volume=440 |issue=7084 |pages=667–670 |doi=10.1038/nature04568 |pmid=16572170 |bibcode=2006Natur.440..667P |url=https://www.nature.com/articles/nature04568 |accessdate=30 March 2006 |language=en |issn=1476-4687}}</ref> [[epistasis]],<ref>{{cite journal |last1=Harrison |first1=Richard |last2=Papp |first2=Balázs |last3=Pál |first3=Csaba |last4=Oliver |first4=Stephen G. |last5=Delneri |first5=Daniela |title=Plasticity of genetic interactions in metabolic networks of yeast |journal=Proceedings of the National Academy of Sciences |date=13 February 2007 |volume=104 |issue=7 |pages=2307–2312 |doi=10.1073/pnas.0607153104 |pmid=17284612 |bibcode=2007PNAS..104.2307H |url=https://www.pnas.org/content/104/7/2307.full |accessdate=February 13, 2007 |language=en |issn=0027-8424}}</ref><ref>{{cite journal |last1=Szappanos |first1=Balázs |last2=Kovács |first2=Károly |last3=Szamecz |first3=Béla |last4=Honti |first4=Frantisek |last5=Costanzo |first5=Michael |last6=Baryshnikova |first6=Anastasia |last7=Gelius-Dietrich |first7=Gabriel |last8=Lercher |first8=Martin J. |last9=Jelasity |first9=Márk |last10=Myers |first10=Chad L. |last11=Andrews |first11=Brenda J. |last12=Boone |first12=Charles |last13=Oliver |first13=Stephen G. |last14=Pál |first14=Csaba |last15=Papp |first15=Balázs |title=An integrated approach to characterize genetic interaction networks in yeast metabolism |journal=Nature Genetics |date=July 2011 |volume=43 |issue=7 |pages=656–662 |doi=10.1038/ng.846 |pmid=21623372 |pmc=3125439 |language=en |issn=1546-1718}}</ref> [[Enzyme promiscuity|promiscuous enzyme reactions]],<ref>{{cite journal |last1=Notebaart |first1=Richard A. |last2=Szappanos |first2=Balázs |last3=Kintses |first3=Bálint |last4=Pál |first4=Ferenc |last5=Györkei |first5=Ádám |last6=Bogos |first6=Balázs |last7=Lázár |first7=Viktória |last8=Spohn |first8=Réka |last9=Csörgő |first9=Bálint |last10=Wagner |first10=Allon |last11=Ruppin |first11=Eytan |last12=Pál |first12=Csaba |last13=Papp |first13=Balázs |title=Network-level architecture and the evolutionary potential of underground metabolism |journal=Proceedings of the National Academy of Sciences |date=12 August 2014 |volume=111 |issue=32 |pages=11762–11767 |doi=10.1073/pnas.1406102111 |pmid=25071190 |bibcode=2014PNAS..11111762N |url=https://www.pnas.org/content/111/32/11762.full |accessdate=August 12, 2014 |language=en |issn=0027-8424}}</ref> and complex adaptations.<ref>{{cite journal |last1=Szappanos |first1=Balázs |last2=Fritzemeier |first2=Jonathan |last3=Csörgő |first3=Bálint |last4=Lázár |first4=Viktória |last5=Lu |first5=Xiaowen |last6=Fekete |first6=Gergely |last7=Bálint |first7=Balázs |last8=Herczeg |first8=Róbert |last9=Nagy |first9=István |last10=Notebaart |first10=Richard A. |last11=Lercher |first11=Martin J. |last12=Pál |first12=Csaba |last13=Papp |first13=Balázs |title=Adaptive evolution of complex innovations through stepwise metabolic niche expansion |journal=Nature Communications |date=20 May 2016 |volume=7 |issue=1 |pages=11607 |doi=10.1038/ncomms11607 |pmid=27197754 |bibcode=2016NatCo...711607S |url=https://www.nature.com/articles/ncomms11607 |accessdate=20 May 2016 |language=en |issn=2041-1723}}</ref>
+The Pal lab has also contributed to the nascent field of evolutionary [[systems biology]].<ref>{{cite journal |last1=Papp |first1=Balázs |last2=Notebaart |first2=Richard A. |last3=Pál |first3=Csaba |title=Systems-biology approaches for predicting genomic evolution |journal=Nature Reviews Genetics |date=September 2011 |volume=12 |issue=9 |pages=591–602 |doi=10.1038/nrg3033 |pmid=21808261 |s2cid=13965868 |url=https://www.nature.com/articles/nrg3033 |accessdate=2 August 2011 |language=en |issn=1471-0064}}</ref> Their research focused on understanding the extent to which evolution is predictable at the molecular level. Using genome-scale [[metabolic network modelling]] combined with experimental tools they studied key issues in [[evolution]], such as mutational [[Robustness (evolution)|robustness]],<ref>{{cite journal |last1=Papp |first1=Balázs |last2=Pál |first2=Csaba |last3=Hurst |first3=Laurence D. |title=Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast |journal=Nature |date=June 2004 |volume=429 |issue=6992 |pages=661–664 |doi=10.1038/nature02636 |pmid=15190353 |bibcode=2004Natur.429..661P |s2cid=492849 |url=https://www.nature.com/articles/nature02636 |accessdate=10 June 2004 |language=en |issn=1476-4687}}</ref> [[horizontal gene transfer]],<ref>{{cite journal |last1=Pál |first1=Csaba |last2=Papp |first2=Balázs |last3=Lercher |first3=Martin J. |title=Adaptive evolution of bacterial metabolic networks by horizontal gene transfer |journal=Nature Genetics |date=December 2005 |volume=37 |issue=12 |pages=1372–1375 |doi=10.1038/ng1686 |pmid=16311593 |s2cid=14611750 |url=https://www.nature.com/articles/ng1686 |accessdate=20 November 2005 |language=en |issn=1546-1718}}</ref> [[Genome size|genome reduction]],<ref>{{cite journal |last1=Pál |first1=Csaba |last2=Papp |first2=Balázs |last3=Lercher |first3=Martin J. |last4=Csermely |first4=Péter |last5=Oliver |first5=Stephen G. |last6=Hurst |first6=Laurence D. |title=Chance and necessity in the evolution of minimal metabolic networks |journal=Nature |date=March 2006 |volume=440 |issue=7084 |pages=667–670 |doi=10.1038/nature04568 |pmid=16572170 |bibcode=2006Natur.440..667P |s2cid=4424895 |url=https://www.nature.com/articles/nature04568 |accessdate=30 March 2006 |language=en |issn=1476-4687}}</ref> [[epistasis]],<ref>{{cite journal |last1=Harrison |first1=Richard |last2=Papp |first2=Balázs |last3=Pál |first3=Csaba |last4=Oliver |first4=Stephen G. |last5=Delneri |first5=Daniela |title=Plasticity of genetic interactions in metabolic networks of yeast |journal=Proceedings of the National Academy of Sciences |date=13 February 2007 |volume=104 |issue=7 |pages=2307–2312 |doi=10.1073/pnas.0607153104 |pmid=17284612 |pmc=1892960 |bibcode=2007PNAS..104.2307H |language=en |issn=0027-8424|doi-access=free }}</ref><ref>{{cite journal |last1=Szappanos |first1=Balázs |last2=Kovács |first2=Károly |last3=Szamecz |first3=Béla |last4=Honti |first4=Frantisek |last5=Costanzo |first5=Michael |last6=Baryshnikova |first6=Anastasia |last7=Gelius-Dietrich |first7=Gabriel |last8=Lercher |first8=Martin J. |last9=Jelasity |first9=Márk |last10=Myers |first10=Chad L. |last11=Andrews |first11=Brenda J. |last12=Boone |first12=Charles |last13=Oliver |first13=Stephen G. |last14=Pál |first14=Csaba |last15=Papp |first15=Balázs |title=An integrated approach to characterize genetic interaction networks in yeast metabolism |journal=Nature Genetics |date=July 2011 |volume=43 |issue=7 |pages=656–662 |doi=10.1038/ng.846 |pmid=21623372 |pmc=3125439 |language=en |issn=1546-1718}}</ref> [[Enzyme promiscuity|promiscuous enzyme reactions]],<ref>{{cite journal |last1=Notebaart |first1=Richard A. |last2=Szappanos |first2=Balázs |last3=Kintses |first3=Bálint |last4=Pál |first4=Ferenc |last5=Györkei |first5=Ádám |last6=Bogos |first6=Balázs |last7=Lázár |first7=Viktória |last8=Spohn |first8=Réka |last9=Csörgő |first9=Bálint |last10=Wagner |first10=Allon |last11=Ruppin |first11=Eytan |last12=Pál |first12=Csaba |last13=Papp |first13=Balázs |title=Network-level architecture and the evolutionary potential of underground metabolism |journal=Proceedings of the National Academy of Sciences |date=12 August 2014 |volume=111 |issue=32 |pages=11762–11767 |doi=10.1073/pnas.1406102111 |pmid=25071190 |pmc=4136603 |bibcode=2014PNAS..11111762N |language=en |issn=0027-8424|doi-access=free }}</ref> and complex adaptations.<ref>{{cite journal |last1=Szappanos |first1=Balázs |last2=Fritzemeier |first2=Jonathan |last3=Csörgő |first3=Bálint |last4=Lázár |first4=Viktória |last5=Lu |first5=Xiaowen |last6=Fekete |first6=Gergely |last7=Bálint |first7=Balázs |last8=Herczeg |first8=Róbert |last9=Nagy |first9=István |last10=Notebaart |first10=Richard A. |last11=Lercher |first11=Martin J. |last12=Pál |first12=Csaba |last13=Papp |first13=Balázs |title=Adaptive evolution of complex innovations through stepwise metabolic niche expansion |journal=Nature Communications |date=20 May 2016 |volume=7 |issue=1 |pages=11607 |doi=10.1038/ncomms11607 |pmid=27197754 |pmc=5411730 |bibcode=2016NatCo...711607S |language=en |issn=2041-1723|doi-access=free }}</ref>
 ==Antibiotic resistance==
-Csaba Pal's laboratory currently studies the problem of [[antibiotic resistance]]. By combining [[Experimental evolution|laboratory evolution]], [[genome sequencing]], and [[functional analysis]], they charted the map of [[evolutionary trade-offs]] between [[antibiotics]]. They found that [[Multiple drug resistance| multidrug resistance mutations]] in [[bacteria]] simultaneously enhance sensitivity to many other unrelated drugs (collateral sensitivity), and explored the underlying molecular mechanisms.<ref>{{Cite journal | doi=10.1038/msb.2013.57| pmid=24169403| title=Bacterial evolution of antibiotic hypersensitivity| journal=Molecular Systems Biology| volume=9| pages=700| year=2013| last1=Lázár| first1=Viktória| last2=Pal Singh| first2=Gajinder| last3=Spohn| first3=Réka| last4=Nagy| first4=István| last5=Horváth| first5=Balázs| last6=Hrtyan| first6=Mónika| last7=Busa‐Fekete| first7=Róbert| last8=Bogos| first8=Balázs| last9=Méhi| first9=Orsolya| last10=Csörgő| first10=Bálint| last11=Pósfai| first11=György| last12=Fekete| first12=Gergely| last13=Szappanos| first13=Balázs| last14=Kégl| first14=Balázs| last15=Papp| first15=Balázs| last16=Pál| first16=Csaba| pmc=3817406}}</ref>
+Csaba Pal's laboratory currently studies the problem of [[antibiotic resistance]]. By combining [[Experimental evolution|laboratory evolution]], [[genome sequencing]], and [[functional analysis]], they charted the map of [[evolutionary trade-offs]] between [[antibiotics]]. They found that [[Multiple drug resistance|multidrug resistance mutations]] in [[bacteria]] simultaneously enhance sensitivity to many other unrelated drugs (collateral sensitivity), and explored the underlying molecular mechanisms.<ref>{{Cite journal | doi=10.1038/msb.2013.57| pmid=24169403| title=Bacterial evolution of antibiotic hypersensitivity| journal=Molecular Systems Biology| volume=9| pages=700| year=2013| last1=Lázár| first1=Viktória| last2=Pal Singh| first2=Gajinder| last3=Spohn| first3=Réka| last4=Nagy| first4=István| last5=Horváth| first5=Balázs| last6=Hrtyan| first6=Mónika| last7=Busa-Fekete| first7=Róbert| last8=Bogos| first8=Balázs| last9=Méhi| first9=Orsolya| last10=Csörgő| first10=Bálint| last11=Pósfai| first11=György| last12=Fekete| first12=Gergely| last13=Szappanos| first13=Balázs| last14=Kégl| first14=Balázs| last15=Papp| first15=Balázs| last16=Pál| first16=Csaba| pmc=3817406}}</ref>
 ==Genome engineering==
-Finally, the Pal lab is an advocate of the emerging field of evolutionary [[genome engineering]].<ref>{{cite web |last1=Bokor |first1=Dóra |title=Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance |url=https://mta.hu/english/directed-evolution-of-multiple-genomic-loci-allows-the-prediction-of-antibiotic-resistance-108792 |website=MTA.hu |accessdate=11 June 2018 |language=hu |date=11 June 2018}}</ref><ref>{{cite journal |last1=Pál |first1=Csaba |last2=Papp |first2=Balázs |last3=Pósfai |first3=György |title=The dawn of evolutionary genome engineering |journal=Nature Reviews Genetics |date=28 May 2014 |volume=15 |issue=7 |pages=504–512 |doi=10.1038/nrg3746 |pmid=24866756 |url=https://www.nature.com/articles/nrg3746 |accessdate=28 May 2014 |language=en |issn=1471-0056}}</ref> Genome engineering enables the modification of specific genomic locations in a directed and combinatorial manner, and allow studying central evolutionary issues in which natural [[genetic variation]] is limited or biased. However, current tools have been optimized for a few laboratory model [[Strain (biology)|strains]], lead to the accumulation of numerous undesired, [[Off-target genome editing|off-target modifications]], and demand extensive modification of the host genome prior to large-scale editing. The Pal laboratory presented a simple, all-in-one solution.<ref>{{cite journal |last1=Nyerges |first1=Ákos |last2=Csörgő |first2=Bálint |last3=Nagy |first3=István |last4=Latinovics |first4=Dóra |last5=Szamecz |first5=Béla |last6=Pósfai |first6=György |last7=Pál |first7=Csaba |title=Conditional DNA repair mutants enable highly precise genome engineering |journal=Nucleic Acids Research |date=1 April 2014 |volume=42 |issue=8 |pages=e62 |doi=10.1093/nar/gku105 |pmid=24500200 |pmc=4005651 |language=en |issn=0305-1048}}</ref><ref>{{cite journal |last1=Nyerges |first1=Ákos |last2=Csörgő |first2=Bálint |last3=Nagy |first3=István |last4=Bálint |first4=Balázs |last5=Bihari |first5=Péter |last6=Lázár |first6=Viktória |last7=Apjok |first7=Gábor |last8=Umenhoffer |first8=Kinga |last9=Bogos |first9=Balázs |last10=Pósfai |first10=György |last11=Pál |first11=Csaba |title=A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species |journal=Proceedings of the National Academy of Sciences |date=11 February 2016 |volume=113 |issue=9 |pages=2502–2507 |doi=10.1073/pnas.1520040113 |pmid=26884157 |pmc=4780621 |bibcode=2016PNAS..113.2502N |url=https://www.pnas.org/content/early/2016/02/10/1520040113 |accessdate=February 16, 2016 |language=en |issn=0027-8424}}</ref> The method is unique as it allows systematic comparison of mutational effects and [[epistasis]] across a wide range of bacterial species.
+Finally, the Pal lab is an advocate of the emerging field of evolutionary [[genome engineering]].<ref>{{cite web |last1=Bokor |first1=Dóra |title=Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance |url=https://mta.hu/english/directed-evolution-of-multiple-genomic-loci-allows-the-prediction-of-antibiotic-resistance-108792 |website=MTA.hu |accessdate=11 June 2018 |language=hu |date=11 June 2018}}</ref><ref>{{cite journal |last1=Pál |first1=Csaba |last2=Papp |first2=Balázs |last3=Pósfai |first3=György |title=The dawn of evolutionary genome engineering |journal=Nature Reviews Genetics |date=28 May 2014 |volume=15 |issue=7 |pages=504–512 |doi=10.1038/nrg3746 |pmid=24866756 |s2cid=6854503 |url=https://www.nature.com/articles/nrg3746 |accessdate=28 May 2014 |language=en |issn=1471-0056}}</ref> Genome engineering enables the modification of specific genomic locations in a directed and combinatorial manner, and allow studying central evolutionary issues in which natural [[genetic variation]] is limited or biased. However, current tools have been optimized for a few laboratory model [[Strain (biology)|strains]], lead to the accumulation of numerous undesired, [[Off-target genome editing|off-target modifications]], and demand extensive modification of the host genome prior to large-scale editing. The Pal laboratory presented a simple, all-in-one solution.<ref>{{cite journal |last1=Nyerges |first1=Ákos |last2=Csörgő |first2=Bálint |last3=Nagy |first3=István |last4=Latinovics |first4=Dóra |last5=Szamecz |first5=Béla |last6=Pósfai |first6=György |last7=Pál |first7=Csaba |title=Conditional DNA repair mutants enable highly precise genome engineering |journal=Nucleic Acids Research |date=1 April 2014 |volume=42 |issue=8 |pages=e62 |doi=10.1093/nar/gku105 |pmid=24500200 |pmc=4005651 |language=en |issn=0305-1048}}</ref><ref>{{cite journal |last1=Nyerges |first1=Ákos |last2=Csörgő |first2=Bálint |last3=Nagy |first3=István |last4=Bálint |first4=Balázs |last5=Bihari |first5=Péter |last6=Lázár |first6=Viktória |last7=Apjok |first7=Gábor |last8=Umenhoffer |first8=Kinga |last9=Bogos |first9=Balázs |last10=Pósfai |first10=György |last11=Pál |first11=Csaba |title=A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species |journal=Proceedings of the National Academy of Sciences |date=11 February 2016 |volume=113 |issue=9 |pages=2502–2507 |doi=10.1073/pnas.1520040113 |pmid=26884157 |pmc=4780621 |bibcode=2016PNAS..113.2502N |language=en |issn=0027-8424|doi-access=free }}</ref> The method is unique as it allows systematic comparison of mutational effects and [[epistasis]] across a wide range of bacterial species.
 ==Awards and honours==
-Csaba Pal received several domestic and international awards, including the [[Lieben Prize|Ignaz Lieben Award]] (2009),<ref>{{cite web |title=Lieben Prize |url=https://en.wikipedia.org/wiki/Lieben_Prize |website=Wikipedia |accessdate=29 January 2020 |language=en |date=17 January 2020}}</ref><ref>{{cite web |title=Csaba Pal |url=https://stipendien.oeaw.ac.at/preise/naturwissenschaften/ignaz-l-lieben-preis/preistraegerinnen/csaba-pal/ |website=stipendien.oeaw.ac.at |accessdate=17 November 2008}}</ref> Szent-Györgyi Talents Award (2014),<ref>{{cite web |title=Szent-Györgyi Talents Award |url=http://www.nobel-szeged.hu/eng/index.php/szegedi-orv-kut-joevojeert-alap/szent-gyoergyi-talents-award |website=www.nobel-szeged.hu |accessdate=29 January 2020}}</ref> and the [[:hu:Bolyai János alkotói díj|Bolyai Prize]] (2015).<ref>{{cite web |title=Pál Csaba biológus a Bolyai-díjas 2015-ben |url=https://bolyai-dij.blog.hu/2015/05/17/pal_csaba_biologus_a_bolyai-dijas_2015-ben |website=Hivatalos weboldalra költözött a Bolyai-díj |accessdate=17 May 2015}}</ref><ref>{{cite web |title=Bolyai-díj – 2015 |url=https://ng.hu/Tudomany/2015/05/18/Bolyai-dij-2015/ |website=National Geographic |accessdate=18 May 2015 |language=hu}}</ref><ref>{{cite web |title=Biologist Csaba Pál is awarded this year's Bolyai Prize |url=https://www.t-systems.hu/news-and-media/news/biologist_Csaba_Pal_is_awarded_this-year_s_bolyai_prize |website=www.t-systems.hu |accessdate= 18 May 2015 |language=en}}</ref><ref>{{cite news |title=Pál Csaba biológus kapta az idei Bolyai-díjat |url=https://hirado.hu/2015/05/17/pal-csaba-biologus-kapta-az-idei-bolyai-dijat/# |accessdate=17 May 2015 |work=hirado.hu |language=hu-HU}}</ref>
+Csaba Pal received several domestic and international awards, including the [[Lieben Prize|Ignaz Lieben Award]] (2009),<ref>{{cite web |title=Lieben Prize |url=https://en.wikipedia.org/wiki/Lieben_Prize |website=Wikipedia |accessdate=29 January 2020 |language=en |date=17 January 2020}}</ref>{{Circular reference|date=November 2020}}<ref>{{cite web |title=Csaba Pal |url=https://stipendien.oeaw.ac.at/preise/naturwissenschaften/ignaz-l-lieben-preis/preistraegerinnen/csaba-pal/ |website=stipendien.oeaw.ac.at |accessdate=17 November 2008 |archive-date=10 April 2019 |archive-url=https://web.archive.org/web/20190410130619/https://stipendien.oeaw.ac.at/preise/naturwissenschaften/ignaz-l-lieben-preis/preistraegerinnen/csaba-pal/ |url-status=dead }}</ref> Szent-Györgyi Talents Award (2014),<ref name="Szent-Györgyi Talents Award">{{cite web |title=Szent-Györgyi Talents Award |url=http://www.nobel-szeged.hu/eng/index.php/szegedi-orv-kut-joevojeert-alap/szent-gyoergyi-talents-award |website=www.nobel-szeged.hu |accessdate=29 January 2020 |archive-date=29 January 2020 |archive-url=https://web.archive.org/web/20200129202856/http://www.nobel-szeged.hu/eng/index.php/szegedi-orv-kut-joevojeert-alap/szent-gyoergyi-talents-award |url-status=dead }}</ref> and the [[:hu:Bolyai János alkotói díj|Bolyai Prize]] (2015).<ref>{{cite web |title=Pál Csaba biológus a Bolyai-díjas 2015-ben |url=https://bolyai-dij.blog.hu/2015/05/17/pal_csaba_biologus_a_bolyai-dijas_2015-ben |website=Hivatalos weboldalra költözött a Bolyai-díj |accessdate=17 May 2015}}</ref><ref>{{cite web |title=Bolyai-díj – 2015 |url=https://ng.hu/Tudomany/2015/05/18/Bolyai-dij-2015/ |website=National Geographic |date=18 May 2015 |accessdate=18 May 2015 |language=hu}}</ref><ref>{{cite web |title=Biologist Csaba Pál is awarded this year's Bolyai Prize |url=https://www.t-systems.hu/news-and-media/news/biologist_Csaba_Pal_is_awarded_this-year_s_bolyai_prize |website=www.t-systems.hu |accessdate= 18 May 2015 |language=en}}</ref><ref>{{cite news |title=Pál Csaba biológus kapta az idei Bolyai-díjat |url=https://hirado.hu/2015/05/17/pal-csaba-biologus-kapta-az-idei-bolyai-dijat/# |accessdate=17 May 2015 |work=hirado.hu |language=hu-HU}}</ref>
-In 2016, Csaba Pal became member of [[Academia Europaea]].<ref>{{cite web |title=Academy of Europe: P%C 3%A 1 l Csaba |url=https://www.ae-info.org/ae/Member/P%C3%A1l_Csaba |website=www.ae-info.org |accessdate=28 January 2020}}</ref> In 2017 he was selected as EMBO ([[European Molecular Biology Organization]]) member.<ref>{{cite web |last1=Jukic |first1=Igor |title=EMBO welcomes 65 new members |url=https://www.embo.org/news/press-releases/2017/embo-welcomes-65-new-members |website=EMBO |accessdate=16 June 2017 |language=en-gb}}</ref><ref>{{cite web |title=Find people in the EMBO Communities |url=https://people.embo.org/profile/csaba-pal |website=people.embo.org |accessdate=28 January 2020}}</ref> and in 2018, became a member of the FEMS. ([[Federation of European Microbiological Societies]])<ref name=FEMS/>
+In 2016, Csaba Pal became member of [[Academia Europaea]].<ref name="ae-info.org">{{cite web |title=Academy of Europe: P%C 3%A 1 l Csaba |url=https://www.ae-info.org/ae/Member/P%C3%A1l_Csaba |website=www.ae-info.org |accessdate=28 January 2020}}</ref> In 2017 he was selected as EMBO ([[European Molecular Biology Organization]]) member.<ref name="EMBO welcomes 65 new members">{{cite web |last1=Jukic |first1=Igor |title=EMBO welcomes 65 new members |url=https://www.embo.org/news/press-releases/2017/embo-welcomes-65-new-members |website=EMBO |accessdate=16 June 2017 |language=en-gb |archive-date=19 June 2017 |archive-url=https://web.archive.org/web/20170619111823/http://embo.org/news/press-releases/2017/embo-welcomes-65-new-members |url-status=dead }}</ref><ref name="people.embo.org">{{cite web |title=Find people in the EMBO Communities |url=https://people.embo.org/profile/csaba-pal |website=people.embo.org |accessdate=28 January 2020}}</ref> and in 2018, became a member of the FEMS. ([[Federation of European Microbiological Societies]])<ref name=FEMS/>
+In 2021 Csaba received and Academic Award<ref>{{cite web | url=https://mta.hu/kozgyules2021/akademiai-elismeresek-a-kozgyulesen-a-dijazottak-nevsora-111383 | title=Akadémiai elismerések a közgyűlésen | date=3 May 2021 }}</ref> and in 2023 he was elected as Corresponding member of the [[Hungarian Academy of Sciences]]<ref>{{cite web | url=https://mta.hu/esemenynaptar/2023-03-14-pal-csaba-antibiotikumok-es-ellenallo-bakteriumok-szekfoglalo-eloadas-4772 | title=Eseménynaptár }}</ref><ref>{{cite web | url=https://www.youtube.com/watch?v=02VH8bFCbY0 | title=Antibiotikumok és ellenálló baktériumok – Pál Csaba székfoglaló előadása (2023.03.14.) | website=[[YouTube]] | date=3 April 2023 }}</ref>
 == References ==
 {{Reflist}}
 {{DEFAULTSORT:Pal, Csaba}}
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 [[Category:Living people]]
 [[Category:Hungarian biologists]]
+[[Category:Members of Academia Europaea]]