LMAN1: Difference between revisions

LMAN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A4U, 3LCP, 3WHT, 3WHU, 3WNX, 4GKX, 4GKY, 4YGC, 4YGD, 4YGE, 4YGB
Identifiers
Aliases	LMAN1, ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58, lectin, mannose binding 1
External IDs	OMIM: 601567; MGI: 1917611; HomoloGene: 4070; GeneCards: LMAN1; OMA:LMAN1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	59,359,265 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	66,155,651 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; jejunal mucosa; ; gingival epithelium; ; corpus epididymis; ; caput epididymis; ; epithelium of nasopharynx; ; secondary oocyte; ; tibia; ; cardia; ; seminal vesicula;
	Top expressed in
	lacrimal gland; ; calvaria; ; salivary gland; ; islet of Langerhans; ; seminal vesicula; ; submandibular gland; ; retinal pigment epithelium; ; ciliary body; ; parotid gland; ; human fetus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; metal ion binding; protein binding; mannose binding; carbohydrate binding;
Cellular component	integral component of membrane; Golgi apparatus; Golgi membrane; sarcomere; host cell perinuclear region of cytoplasm; endoplasmic reticulum; ER to Golgi transport vesicle membrane; extracellular exosome; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; COPII-coated ER to Golgi transport vesicle;
Biological process	Golgi organization; early endosome to Golgi transport; blood coagulation; positive regulation of organelle organization; protein N-linked glycosylation via asparagine; COPII vesicle coating; protein exit from endoplasmic reticulum; protein folding; protein transport; vesicle-mediated transport; endoplasmic reticulum to Golgi vesicle-mediated transport; endoplasmic reticulum organization; transport;
	Sources:Amigo / QuickGO
Orthologs
	3998
	70361
	ENSG00000074695
	ENSMUSG00000041891
	P49257
	Q9D0F3
	NM_005570
	NM_001172062; NM_027400
	NP_005561
	NP_001165533; NP_081676
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 04:49, 14 October 2024

Protein ERGIC-53 also known as ER-Golgi intermediate compartment 53 kDa protein or lectin mannose-binding 1 is a protein that in humans is encoded by the LMAN1 gene.^[5]^[6]^[7]

Function

ERGIC-53 (also named LMAN1) is a type I integral membrane protein localized in the intermediate region (ERGIC) between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined deficiency of factor V-factor VIII, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.^[8]^[7] MCFD2 is the second gene that leads to combined deficiency of factor V-factor VIII.^[9] ERGIC-53 and MCFD2 form a protein complex and serve as a cargo receptor to transport FV and FVIII from the ER to the ERGIC and then the Golgi,^[10]as illustrated here.^[8]

Clinical significance

LMAN1 mutational inactivation is a frequent and early event potentially contributing to colorectal tumorigenesis.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000074695 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041891 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nichols WC, Seligsohn U, Zivelin A, Terry VH, Hertel CE, Wheatley MA, Moussalli MJ, Hauri HP, Ciavarella N, Kaufman RJ, Ginsburg D (May 1998). "Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII". Cell. 93 (1): 61–70. doi:10.1016/S0092-8674(00)81146-0. PMID 9546392. S2CID 15021770.
^ Arar C, Mignon C, Mattei M, Monsigny M, Roche A, Legrand A (Feb 1997). "Mapping of the MR60/ERGIC-53 gene to human chromosome 18q21.3-18q22 by in situ hybridization". Mamm Genome. 7 (10): 791–2. doi:10.1007/s003359900238. PMID 8854877. S2CID 19754504.
^ ^a ^b "Entrez Gene: LMAN1 lectin, mannose-binding, 1".
^ ^a ^b Khoriaty R, Vasievich MP, Ginsburg D (July 2012). "The COPII pathway and hematologic disease". Blood. 120 (1): 31–8. doi:10.1182/blood-2012-01-292086. PMC 3390960. PMID 22586181.
^ Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, Ginsburg D (May 2003). "Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex". Nat Genet. 34 (2): 220–5. doi:10.1038/ng1153. PMID 12717434. S2CID 19281158.
^ Zhang B, Kaufman RJ, Ginsburg D (2005). "LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway". J. Biol. Chem. 280 (27): 25881–6. doi:10.1074/jbc.M502160200. PMID 15886209.
^ Roeckel N, Woerner SM, Kloor M, Yuan YP, Patsos G, Gromes R, Kopitz J, Gebert J (January 2009). "High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability". Cancer Res. 69 (1): 292–9. doi:10.1158/0008-5472.CAN-08-3314. PMID 19118014.

Botos I, Wlodawer A (2005). "Proteins that bind high-mannose sugars of the HIV envelope". Prog. Biophys. Mol. Biol. 88 (2): 233–82. doi:10.1016/j.pbiomolbio.2004.05.001. PMID 15572157.
Arar C, Carpentier V, Le Caer JP, et al. (1995). "ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells". J. Biol. Chem. 270 (8): 3551–3. doi:10.1074/jbc.270.8.3551. PMID 7876089.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Fiedler K, Simons K (1994). "A putative novel class of animal lectins in the secretory pathway homologous to leguminous lectins". Cell. 77 (5): 625–6. doi:10.1016/0092-8674(94)90047-7. PMID 8205612. S2CID 21111364.
Schindler R, Itin C, Zerial M, et al. (1993). "ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif". Eur. J. Cell Biol. 61 (1): 1–9. PMID 8223692.
Haurum JS, Thiel S, Jones IM, et al. (1994). "Complement activation upon binding of mannan-binding protein to HIV envelope glycoproteins". AIDS. 7 (10): 1307–13. doi:10.1097/00002030-199310000-00002. PMID 8267903. S2CID 25026640.
Senaldi G, Davies ET, Mahalingam M, et al. (1996). "Circulating levels of mannose binding protein in human immunodeficiency virus infection". J. Infect. 31 (2): 145–8. doi:10.1016/S0163-4453(95)92185-0. PMID 8666845.
Neerman-Arbez M, Antonarakis SE, Blouin JL, et al. (1997). "The locus for combined factor V-factor VIII deficiency (F5F8D) maps to 18q21, between D18S849 and D18S1103". Am. J. Hum. Genet. 61 (1): 143–50. doi:10.1086/513897. PMC 1715850. PMID 9245995.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nichols WC, Terry VH, Wheatley MA, et al. (1999). "ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families". Blood. 93 (7): 2261–6. PMID 10090935.
Saifuddin M, Hart ML, Gewurz H, et al. (2000). "Interaction of mannose-binding lectin with primary isolates of human immunodeficiency virus type 1". J. Gen. Virol. 81 (Pt 4): 949–55. doi:10.1099/0022-1317-81-4-949. PMID 10725420.
Harris RA, Yang A, Stein RC, et al. (2002). "Cluster analysis of an extensive human breast cancer cell line protein expression map database". Proteomics. 2 (2): 212–23. doi:10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO;2-H. PMID 11840567. S2CID 44946014.
Jüliger S, Kremsner PG, Alpers MP, et al. (2002). "Restricted polymorphisms of the mannose-binding lectin gene in a population of Papua New Guinea". Mutat. Res. 505 (1–2): 87–91. doi:10.1016/S0027-5107(02)00142-2. PMID 12175909.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hart ML, Saifuddin M, Uemura K, et al. (2003). "High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1". AIDS Res. Hum. Retroviruses. 18 (17): 1311–7. doi:10.1089/088922202320886352. PMID 12487819.
Hart ML, Saifuddin M, Spear GT (2003). "Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin". J. Gen. Virol. 84 (Pt 2): 353–60. doi:10.1099/vir.0.18734-0. PMID 12560567.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
García-Laorden MI, Rúa-Figueroa I, Pérez-Aciego P, et al. (2003). "Mannose binding lectin polymorphisms as a disease-modulating factor in women with systemic lupus erythematosus from Canary Islands, Spain". J. Rheumatol. 30 (4): 740–6. PMID 12672193.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000074695 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041891 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9546392-5] Nichols WC, Seligsohn U, Zivelin A, Terry VH, Hertel CE, Wheatley MA, Moussalli MJ, Hauri HP, Ciavarella N, Kaufman RJ, Ginsburg D (May 1998). "Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII". Cell. 93 (1): 61–70. doi:10.1016/S0092-8674(00)81146-0. PMID 9546392. S2CID 15021770.

[pmid8854877-6] Arar C, Mignon C, Mattei M, Monsigny M, Roche A, Legrand A (Feb 1997). "Mapping of the MR60/ERGIC-53 gene to human chromosome 18q21.3-18q22 by in situ hybridization". Mamm Genome. 7 (10): 791–2. doi:10.1007/s003359900238. PMID 8854877. S2CID 19754504.

[entrez-7] "Entrez Gene: LMAN1 lectin, mannose-binding, 1".

[blood-8] Khoriaty R, Vasievich MP, Ginsburg D (July 2012). "The COPII pathway and hematologic disease". Blood. 120 (1): 31–8. doi:10.1182/blood-2012-01-292086. PMC 3390960. PMID 22586181.

[pmid12717434-9] Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, Ginsburg D (May 2003). "Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex". Nat Genet. 34 (2): 220–5. doi:10.1038/ng1153. PMID 12717434. S2CID 19281158.

[pmid15886209-10] Zhang B, Kaufman RJ, Ginsburg D (2005). "LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway". J. Biol. Chem. 280 (27): 25881–6. doi:10.1074/jbc.M502160200. PMID 15886209.

[pmid19118014-11] Roeckel N, Woerner SM, Kloor M, Yuan YP, Patsos G, Gromes R, Kopitz J, Gebert J (January 2009). "High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability". Cancer Res. 69 (1): 292–9. doi:10.1158/0008-5472.CAN-08-3314. PMID 19118014.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
 {{Infobox_gene}}
-'''Protein ERGIC-53''' also known as '''ER-Golgi intermediate compartment 53 kDa protein''' or '''lectin mannose-binding 1''' is a [[protein]] that in humans is encoded by the ''LMAN1'' [[gene]].<ref name="pmid9546392">{{cite journal |vauthors=Nichols WC, Seligsohn U, Zivelin A, Terry VH, Hertel CE, Wheatley MA, Moussalli MJ, Hauri HP, Ciavarella N, Kaufman RJ, Ginsburg D | title = Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII | journal = Cell | volume = 93 | issue = 1 | pages = 61–70 |date=May 1998 | pmid = 9546392 | pmc =  | doi =10.1016/S0092-8674(00)81146-0  }}</ref><ref name="pmid8854877">{{cite journal |vauthors=Arar C, Mignon C, Mattei M, Monsigny M, Roche A, Legrand A | title = Mapping of the MR60/ERGIC-53 gene to human chromosome 18q21.3-18q22 by in situ hybridization | journal = Mamm Genome | volume = 7 | issue = 10 | pages = 791–2 |date=Feb 1997 | pmid = 8854877 | pmc =  | doi =10.1007/s003359900238  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LMAN1 lectin, mannose-binding, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3998| accessdate = }}</ref>
+'''Protein ERGIC-53''' also known as '''ER-Golgi intermediate compartment 53 kDa protein''' or '''lectin mannose-binding 1''' is a [[protein]] that in humans is encoded by the ''LMAN1'' [[gene]].<ref name="pmid9546392">{{cite journal |vauthors=Nichols WC, Seligsohn U, Zivelin A, Terry VH, Hertel CE, Wheatley MA, Moussalli MJ, Hauri HP, Ciavarella N, Kaufman RJ, Ginsburg D | title = Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII | journal = Cell | volume = 93 | issue = 1 | pages = 61–70 |date=May 1998 | pmid = 9546392 | doi =10.1016/S0092-8674(00)81146-0  | s2cid = 15021770 | doi-access = free }}</ref><ref name="pmid8854877">{{cite journal |vauthors=Arar C, Mignon C, Mattei M, Monsigny M, Roche A, Legrand A | title = Mapping of the MR60/ERGIC-53 gene to human chromosome 18q21.3-18q22 by in situ hybridization | journal = Mamm Genome | volume = 7 | issue = 10 | pages = 791–2 |date=Feb 1997 | pmid = 8854877 | doi =10.1007/s003359900238  | s2cid = 19754504 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LMAN1 lectin, mannose-binding, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3998}}</ref>
 == Function ==
-ERGIC-53 (also named LMAN1) is a type I integral [[membrane protein]] localized in the intermediate region ([[ERGIC]]) between the [[endoplasmic reticulum]] and the [[Golgi apparatus|Golgi]], presumably recycling between the two compartments. The protein is a [[mannose]]-specific [[lectin]] and is a member of a novel family of plant lectin homologs in the [[secretory pathway]] of animal cells. Mutations in the gene are associated with a [[coagulation]] defect. Using positional cloning, the gene was identified as the disease gene leading to combined deficiency of factor V-factor VIII, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.<ref name="blood">{{cite web|last1=Khoriaty R, Vasievich MP, Ginsburg D.|first1=Blood. 2012 Jul 5;120(1):31-8. doi: 10.1182/blood-2012-01-292086|title=The COPII pathway and hematologic disease.|url=http://www.bloodjournal.org/content/120/1/31?sso-checked=true|website=www.bloodjournal.org|publisher=American Society of Hematology|accessdate=7 April 2017}}</ref><ref name="entrez" /> [[MCFD2]] is the second gene that leads to combined deficiency of factor V-factor VIII.<ref name="pmid12717434">{{cite journal |vauthors=Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, Ginsburg D | title = Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex | journal = Nat Genet | volume = 34 | issue = 2 | pages = 220–5 |date=May 2003 | pmid = 12717434 | pmc =  | doi = 10.1038/ng1153 }}</ref> ERGIC-53 and MCFD2  form a protein complex and serve as a cargo receptor to transport FV and FVIII from the ER to the ERGIC and then the Golgi,<ref name="pmid15886209">{{cite journal  |vauthors=Zhang B, Kaufman RJ, Ginsburg D |title=LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway |journal=J. Biol. Chem. |volume=280 |issue= 27 |pages= 25881–6 |year= 2005 |pmid= 15886209 |doi= 10.1074/jbc.M502160200 }}</ref>[http://www.bloodjournal.org/content/bloodjournal/120/1/31/F2.large.jpg as illustrated here.]<ref name=blood/>
+ERGIC-53 (also named LMAN1) is a type I integral [[membrane protein]] localized in the intermediate region ([[ERGIC]]) between the [[endoplasmic reticulum]] and the [[Golgi apparatus|Golgi]], presumably recycling between the two compartments. The protein is a [[mannose]]-specific [[lectin]] and is a member of a novel family of plant lectin homologs in the [[secretory pathway]] of animal cells. Mutations in the gene are associated with a [[coagulation]] defect. Using positional cloning, the gene was identified as the disease gene leading to combined deficiency of factor V-factor VIII, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.<ref name="blood">{{cite journal | vauthors = Khoriaty R, Vasievich MP, Ginsburg D | title = The COPII pathway and hematologic disease | journal = Blood | volume = 120 | issue = 1 | pages = 31–8 | date = July 2012 | pmid = 22586181 | pmc = 3390960 | doi = 10.1182/blood-2012-01-292086 }}</ref><ref name="entrez" /> [[MCFD2]] is the second gene that leads to combined deficiency of factor V-factor VIII.<ref name="pmid12717434">{{cite journal |vauthors=Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, Ginsburg D | title = Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex | journal = Nat Genet | volume = 34 | issue = 2 | pages = 220–5 |date=May 2003 | pmid = 12717434 | doi = 10.1038/ng1153 | s2cid = 19281158 }}</ref> ERGIC-53 and MCFD2  form a protein complex and serve as a cargo receptor to transport FV and FVIII from the ER to the ERGIC and then the Golgi,<ref name="pmid15886209">{{cite journal  |vauthors=Zhang B, Kaufman RJ, Ginsburg D |title=LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway |journal=J. Biol. Chem. |volume=280 |issue= 27 |pages= 25881–6 |year= 2005 |pmid= 15886209 |doi= 10.1074/jbc.M502160200 |doi-access= free }}</ref>[http://www.bloodjournal.org/content/bloodjournal/120/1/31/F2.large.jpg as illustrated here.]<ref name=blood/>
 ==Clinical significance==
-LMAN1 [[mutation]]al inactivation is a frequent and early event potentially contributing to [[colorectal cancer|colorectal tumorigenesis]].<ref name="pmid19118014">{{cite journal |vauthors=Roeckel N, Woerner SM, Kloor M, Yuan YP, Patsos G, Gromes R, Kopitz J, Gebert J | title = High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability | journal = Cancer Res. | volume = 69 | issue = 1 | pages = 292–9 |date=January 2009 | pmid = 19118014 | doi = 10.1158/0008-5472.CAN-08-3314 | url =  }}</ref>
+LMAN1 [[mutation]]al inactivation is a frequent and early event potentially contributing to [[colorectal cancer|colorectal tumorigenesis]].<ref name="pmid19118014">{{cite journal |vauthors=Roeckel N, Woerner SM, Kloor M, Yuan YP, Patsos G, Gromes R, Kopitz J, Gebert J | title = High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability | journal = Cancer Res. | volume = 69 | issue = 1 | pages = 292–9 |date=January 2009 | pmid = 19118014 | doi = 10.1158/0008-5472.CAN-08-3314 | doi-access = free }}</ref>
 ==References==
@@ Line 15: / Line 16: @@
 ==Further reading==
 {{refbegin | 2}}
-*{{cite journal  |vauthors=Botos I, Wlodawer A |title=Proteins that bind high-mannose sugars of the HIV envelope |journal=Prog. Biophys. Mol. Biol. |volume=88 |issue= 2 |pages= 233–82 |year= 2005 |pmid= 15572157 |doi= 10.1016/j.pbiomolbio.2004.05.001 }}
+*{{cite journal  |vauthors=Botos I, Wlodawer A |title=Proteins that bind high-mannose sugars of the HIV envelope |journal=Prog. Biophys. Mol. Biol. |volume=88 |issue= 2 |pages= 233–82 |year= 2005 |pmid= 15572157 |doi= 10.1016/j.pbiomolbio.2004.05.001 |doi-access= free }}
-*{{cite journal   |vauthors=Arar C, Carpentier V, Le Caer JP, etal |title=ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells |journal=J. Biol. Chem. |volume=270 |issue= 8 |pages= 3551–3 |year= 1995 |pmid= 7876089 |doi=10.1074/jbc.270.8.3551  }}
+*{{cite journal   |vauthors=Arar C, Carpentier V, Le Caer JP, etal |title=ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells |journal=J. Biol. Chem. |volume=270 |issue= 8 |pages= 3551–3 |year= 1995 |pmid= 7876089 |doi=10.1074/jbc.270.8.3551  |doi-access=free }}
 *{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  |vauthors=Fiedler K, Simons K |title=A putative novel class of animal lectins in the secretory pathway homologous to leguminous lectins |journal=Cell |volume=77 |issue= 5 |pages= 625–6 |year= 1994 |pmid= 8205612 |doi=10.1016/0092-8674(94)90047-7  }}
+*{{cite journal  |vauthors=Fiedler K, Simons K |title=A putative novel class of animal lectins in the secretory pathway homologous to leguminous lectins |journal=Cell |volume=77 |issue= 5 |pages= 625–6 |year= 1994 |pmid= 8205612 |doi=10.1016/0092-8674(94)90047-7  |s2cid=21111364 }}
-*{{cite journal   |vauthors=Schindler R, Itin C, Zerial M, etal |title=ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif |journal=Eur. J. Cell Biol. |volume=61 |issue= 1 |pages= 1–9 |year= 1993 |pmid= 8223692 |doi=  }}
+*{{cite journal   |vauthors=Schindler R, Itin C, Zerial M, etal |title=ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif |journal=Eur. J. Cell Biol. |volume=61 |issue= 1 |pages= 1–9 |year= 1993 |pmid= 8223692 }}
-*{{cite journal   |vauthors=Haurum JS, Thiel S, Jones IM, etal |title=Complement activation upon binding of mannan-binding protein to HIV envelope glycoproteins |journal=AIDS |volume=7 |issue= 10 |pages= 1307–13 |year= 1994 |pmid= 8267903 |doi=10.1097/00002030-199310000-00002  }}
+*{{cite journal   |vauthors=Haurum JS, Thiel S, Jones IM, etal |title=Complement activation upon binding of mannan-binding protein to HIV envelope glycoproteins |journal=AIDS |volume=7 |issue= 10 |pages= 1307–13 |year= 1994 |pmid= 8267903 |doi=10.1097/00002030-199310000-00002  |s2cid=25026640 }}
 *{{cite journal   |vauthors=Senaldi G, Davies ET, Mahalingam M, etal |title=Circulating levels of mannose binding protein in human immunodeficiency virus infection |journal=J. Infect. |volume=31 |issue= 2 |pages= 145–8 |year= 1996 |pmid= 8666845 |doi=10.1016/S0163-4453(95)92185-0  }}
 *{{cite journal   |vauthors=Neerman-Arbez M, Antonarakis SE, Blouin JL, etal |title=The locus for combined factor V-factor VIII deficiency (F5F8D) maps to 18q21, between D18S849 and D18S1103 |journal=Am. J. Hum. Genet. |volume=61 |issue= 1 |pages= 143–50 |year= 1997 |pmid= 9245995 |doi=10.1086/513897  | pmc=1715850  }}
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