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== Methamphetamine as neurotoxin ==

The article calls meth a "neurotoxin and" cns stimulant. This is technically correct, I guess, since, as mentioned in the article cited, meth is neurotoxic. Pretty much all stimulants that act on norepinephrine and dopamine are neurotoxic in high enough doses over long enough periods of time. It's silly to include that neurotoxicity in the drug's definition. I'm rewriting. [[User:Quodfui|Quodfui]] ([[User talk:Quodfui|talk]]) 20:32, 19 November 2014 (UTC)

:I don't have time to deal with this - there are some good sources there that I don't want to remove, but as that section is set up right now it has a pov beyond that expressed in its sources. This article seems to have devolved into a discussion of stimulants as street drugs even though there are a variety of legitimate uses for which they are prescribed. [[User:Quodfui|Quodfui]] ([[User talk:Quodfui|talk]]) 20:46, 19 November 2014 (UTC)

Methamphetamine happens to possess uniquely individual properties among which include its comparative degree of neuronal toxicity even compared to other hard or "amphetamine-type" stimulants. This is simply the truth - the DEA can go fly a kite as far as I'm concerned, but they are veracious in stating to the public methamphetamine is uniquely toxic to the human brain system. I pass no judgment on Desoxyn users (usage thereof may be had without serious critical toxicity if intelligently done) but yeah, meth is heavy, hard stuff. We must report reality. Only cocaine and meth rival each other in brain damage potential in the stimulant group. <small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/2602:304:B34B:A940:F051:AB0F:3A76:DE48|2602:304:B34B:A940:F051:AB0F:3A76:DE48]] ([[User talk:2602:304:B34B:A940:F051:AB0F:3A76:DE48|talk]])
04:27, 19 June 2015 (UTC)</small><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->
:Methamphetamine is ''far'' from being "uniquely" toxic. It seems to me a more useful presentation would be a discussion of ''relative'' neurotoxicity of different substituted phenethylamines & related psychedelics. In my college days I came across a paper studying just this. Some compounds caused severe irreversible brain damage after a single dose, which makes meth look benign. I was sufficiently horrified to avoid all such drugs not just through the glorious 60s but for the next 40 years.

:IIRC, the chief culprit was the position & number of hydroxyl groups. Shift an -OH group one position and a relatively safe compound became acutely toxic. This is of more than academic interest when the possibility of contaminated street drugs is considered. I don't have much hope of finding that 1960s paper now, but there must be more recent work.

:The technical details don't belong in ''this'' article, but I think a brief mention is in order here. I'm putting this article on my "to-do" watchlist as I see other bits that could use improving, but as usual feel free to jump in. --[[User:D A Patriarche|D Anthony Patriarche, BSc]] ([[User talk:D A Patriarche|talk]]) 18:41, 6 May 2020 (UTC)


== External links modified ==
== External links modified ==
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==MDMA is an amphetamine, why separete it?==
==MDMA is an amphetamine, why separete it?==
In the introductory section MDMA is listed as separeted from the amphetamines: ''It is estimated that the percent of the population that has abused amphetamines, cocaine and MDMA combined is between .8% and 2.1%''; Because MDMA is an amphetamine I'll edit this phrase to: ''It is estimated that the combined percentage of the population that has abused amphetamines or cocaine is between 0.8% and 2.1%.". <!-- Template:Unsigned --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Gottliber|Gottliber]] ([[User talk:Gottliber#top|talk]] • [[Special:Contributions/Gottliber|contribs]]) 22:30, 13 October 2017 (UTC)</small>
In the introductory section MDMA is listed as separeted from the amphetamines: ''It is estimated that the percent of the population that has abused amphetamines, cocaine and MDMA combined is between .8% and 2.1%''; Because MDMA is an amphetamine I'll edit this phrase to: ''It is estimated that the combined percentage of the population that has abused amphetamines or cocaine is between 0.8% and 2.1%.". <!-- Template:Unsigned --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Gottliber|Gottliber]] ([[User talk:Gottliber#top|talk]] • [[Special:Contributions/Gottliber|contribs]]) 22:30, 13 October 2017 (UTC)</small>
:Fair point. {{Fixed}} it. [[User:Seppi333|'''<font color="#32CD32">Seppi</font>''<font color="Black">333</font>''''']]&nbsp;([[User Talk:Seppi333|Insert&nbsp;'''2¢''']]) 03:32, 14 October 2017 (UTC)
:Fair point. {{Fixed}} it. [[User:Seppi333|'''<span style="color:#32CD32;">Seppi</span>''<span style="color:Black;">333</span>''''']]&nbsp;([[User Talk:Seppi333|Insert&nbsp;'''2¢''']]) 03:32, 14 October 2017 (UTC)


The sentence, in its original form as well as in its new form, is not easily verified from the cited source. The closest I found was a table on page 149 which provides estimated '''annual''' prevalence (not lifetime or necessarily abuse) of Cocaine, "Amphetamines and prescription stimulants" and Ecstasy. Adding the global prevalences of Cocaine and "Amphetamines and prescription stimulants" gives a range of 0.6-1.5 %. Also including Ecstasy, however, results in the cited 0.8-2.1 %. Hm, I will try to fix it now. [[User:Ehasl|Elias]] ([[User talk:Ehasl|talk]]) 11:34, 24 September 2020 (UTC)
The sentence, in its original form as well as in its new form, is not easily verified from the cited source. The closest I found was a table on page 149 which provides estimated '''annual''' prevalence (not lifetime or necessarily abuse) of Cocaine, "Amphetamines and prescription stimulants" and Ecstasy. Adding the global prevalences of Cocaine and "Amphetamines and prescription stimulants" gives a range of 0.6-1.5 %. Also including Ecstasy, however, results in the cited 0.8-2.1 %. Hm, I will try to fix it now. [[User:Ehasl|Elias]] ([[User talk:Ehasl|talk]]) 11:34, 24 September 2020 (UTC)
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An editor has asked for a discussion to address the redirect [[Phenatine]]. Please participate in [[Wikipedia:Redirects for discussion/Log/2020 January 30#Phenatine|the redirect discussion]] if you wish to do so. <!-- from Template:RFDNote --> [[User:Hairy Dude|Hairy Dude]] ([[User talk:Hairy Dude|talk]]) 14:25, 30 January 2020 (UTC)
An editor has asked for a discussion to address the redirect [[Phenatine]]. Please participate in [[Wikipedia:Redirects for discussion/Log/2020 January 30#Phenatine|the redirect discussion]] if you wish to do so. <!-- from Template:RFDNote --> [[User:Hairy Dude|Hairy Dude]] ([[User talk:Hairy Dude|talk]]) 14:25, 30 January 2020 (UTC)
:NB--the above discussion is now '''closed'''. Decision was '''delete'''. --[[User:D A Patriarche|D Anthony Patriarche, BSc]] ([[User talk:D A Patriarche|talk]]) 18:51, 6 May 2020 (UTC)
:NB--the above discussion is now '''closed'''. Decision was '''delete'''. --[[User:D A Patriarche|D Anthony Patriarche, BSc]] ([[User talk:D A Patriarche|talk]]) 18:51, 6 May 2020 (UTC)

== Recreational use and issues of abuse ==

So, I am interested in the contents of the table, cited as [126]. I have had access to the original article and said table is not present there. It would seem it made of some data taken from a larger table, but if that is the case, the numbers do not correspond. Also, there doesn't seem to be methamphetamine in the table of the cited article. Where was the data in (and) the table taken from? I believe either the data is wrong or this is not cited correctly. Also, I'm interested in the source of the table. Thank you! <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/83.29.135.123|83.29.135.123]] ([[User talk:83.29.135.123#top|talk]]) 14:07, 28 October 2021 (UTC)</small> <!--Autosigned by SineBot-->

:The source is in the references, but the numbering is all messed up. It's at https://doi.org/10.1016/S0140-6736(07)60464-4. The methamphetamine entry wasn't there, so I removed it. [[User:Sonic The Holoprosencephalous|Sonic The Holoprosencephalous]] ([[User talk:Sonic The Holoprosencephalous|talk]]) 15:52, 8 November 2021 (UTC)

Latest revision as of 04:34, 20 October 2024


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MDMA is not a stimulant and should not be listed in this article as one

[edit]

MDMA is a psychedelic which means it is between stimulant and hallucinogen. It's inclusion in the stimulants list is inappropriate. If we are including MDMA as a pure stimulant we would also have to include LSD, DMT, DPT ect which all have a very significant stimulating effect on humans. Boilingorangejuice (talk) 20:06, 29 May 2016 (UTC)[reply]

Do you have a source for this definition of psychedelic drug? It doesn't seem to match our article. Sizeofint (talk) 20:21, 29 May 2016 (UTC)[reply]
Also MDMA has reliable sources stating it is a stimulant. Sizeofint (talk) 22:00, 29 May 2016 (UTC)[reply]
Well, given that reasoning I will be adding LSD and psilocybin to the stimulants list given that while they are mainly known for their hallucinogenic effects they are also stimulating. Boilingorangejuice (talk) 07:42, 8 June 2016 (UTC)[reply]
If you find WP:MEDRS sources stating LSD and psilocybin are stimulants then do so. I have not seen any however. Sizeofint (talk) 09:21, 8 June 2016 (UTC)[reply]

MDMA is an amphetamine, why separete it?

[edit]

In the introductory section MDMA is listed as separeted from the amphetamines: It is estimated that the percent of the population that has abused amphetamines, cocaine and MDMA combined is between .8% and 2.1%; Because MDMA is an amphetamine I'll edit this phrase to: It is estimated that the combined percentage of the population that has abused amphetamines or cocaine is between 0.8% and 2.1%.". — Preceding unsigned comment added by Gottliber (talkcontribs) 22:30, 13 October 2017 (UTC)[reply]

Fair point.  Fixed it. Seppi333 (Insert ) 03:32, 14 October 2017 (UTC)[reply]

The sentence, in its original form as well as in its new form, is not easily verified from the cited source. The closest I found was a table on page 149 which provides estimated annual prevalence (not lifetime or necessarily abuse) of Cocaine, "Amphetamines and prescription stimulants" and Ecstasy. Adding the global prevalences of Cocaine and "Amphetamines and prescription stimulants" gives a range of 0.6-1.5 %. Also including Ecstasy, however, results in the cited 0.8-2.1 %. Hm, I will try to fix it now. Elias (talk) 11:34, 24 September 2020 (UTC)[reply]

PS: I realized now that adding the prevalences is simply wrong, since there will be (I would expect large) overlaps between the users of each compound/category. The statistics must be cited individually. I think one can drop the confidence intervals and just use the point estimates, though. I will try to fix it now.Elias (talk) 12:11, 24 September 2020 (UTC)[reply]

"Phenatine" listed at Redirects for discussion

[edit]

An editor has asked for a discussion to address the redirect Phenatine. Please participate in the redirect discussion if you wish to do so. Hairy Dude (talk) 14:25, 30 January 2020 (UTC)[reply]

NB--the above discussion is now closed. Decision was delete. --D Anthony Patriarche, BSc (talk) 18:51, 6 May 2020 (UTC)[reply]

Recreational use and issues of abuse

[edit]

So, I am interested in the contents of the table, cited as [126]. I have had access to the original article and said table is not present there. It would seem it made of some data taken from a larger table, but if that is the case, the numbers do not correspond. Also, there doesn't seem to be methamphetamine in the table of the cited article. Where was the data in (and) the table taken from? I believe either the data is wrong or this is not cited correctly. Also, I'm interested in the source of the table. Thank you! — Preceding unsigned comment added by 83.29.135.123 (talk) 14:07, 28 October 2021 (UTC)[reply]

The source is in the references, but the numbering is all messed up. It's at https://doi.org/10.1016/S0140-6736(07)60464-4. The methamphetamine entry wasn't there, so I removed it. Sonic The Holoprosencephalous (talk) 15:52, 8 November 2021 (UTC)[reply]