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Glycyrrhizol: Difference between revisions

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Updating {{chembox}} (changes to verified and watched fields - updated 'CASNo_Ref', 'ChEBI_Ref', 'Verifiedfields') per Chem/Drugbox validation (report errors or bugs)
 
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| ImageFile = Glycyrrhizol A.png
| ImageFile = Glycyrrhizol A.png
| ImageSize = 200px
| ImageSize = 200px
| IUPACName = 1-Methoxy-2,8-bis-(3-methyl-but-2-enyl)-6''H''-[1]benzofuro[3,2-c]chromene-3,9-diol
| PIN = 1-Methoxy-2,8-bis(3-methylbut-2-en-1-yl)-6''H''-[1]benzofuro[3,2-''c''] [1]benzopyran-3,9-diol
| OtherNames =
| OtherNames =
|Section1={{Chembox Identifiers
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
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| CASNo_Ref = {{cascite|correct|??}}
| CASNo_Ref = {{cascite|correct|??}}
| CASNo = 877373-00-7
| CASNo = 877373-00-7
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 84L7S5MVN5
| PubChem = 11546269
| PubChem = 11546269
| SMILES = o2c1c(cc(c(O)c1)C\C=C(/C)C)c3c2c4c(OC)c(c(O)cc4OC3)C\C=C(/C)C
| SMILES = o2c1c(cc(c(O)c1)C\C=C(/C)C)c3c2c4c(OC)c(c(O)cc4OC3)C\C=C(/C)C
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| Formula = C<sub>26</sub>H<sub>28</sub>O<sub>5</sub>
| Formula = C<sub>26</sub>H<sub>28</sub>O<sub>5</sub>
| MolarMass = 420.50 g/mol
| MolarMass = 420.50 g/mol
| Appearance =
| Appearance =
| Density =
| Density =
| MeltingPt =
| MeltingPt =
| BoilingPt =
| BoilingPt =
| Solubility = }}
| Solubility = }}
|Section3={{Chembox Hazards
|Section3={{Chembox Hazards
| MainHazards =
| MainHazards =
| FlashPt =
| FlashPt =
| AutoignitionPt = }}
| AutoignitionPt = }}
}}
}}


'''Glycyrrhizol A''' is a [[prenylated]] [[pterocarpan]], a derivative of [[isoflavonoid]]s. It is a compound isolated from the root of the Chinese [[Licorice]] plant (''[[Glycyrrhiza uralensis]]'').
'''Glycyrrhizol A''' is a [[prenylated]] [[pterocarpan]] and an [[isoflavonoid]] derivative. It is a compound isolated from the root of the [[Glycyrrhiza uralensis|Chinese licorice plant]] (''Glycyrrhiza uralensis'').{{cn|date=February 2023}}


Recent studies by scientists from [[University of California, Los Angeles|UCLA]] have suggested that these compounds have [[antibacterial]] properties.<ref>{{cite journal | author= He J, Chen L, Shi W, Lu, Q-Y | title=Antibacterial Compounds from ''Glycyrrhiza uralensis'' | journal=[[Journal of Natural Products]] | volume=69| issue=1 | year=2006 | pages=121–124 | id= | doi=10.1021/np058069d | pmid= 16441081}}</ref> The strongest antibacterial activity was observed against ''[[Streptococcus mutans]]'', an organism known to cause tooth decay in humans.
It may has ''[[in vitro]]'' [[antibacterial]] properties.<ref name = He>{{cite journal | vauthors= He J, Chen L, Shi W, ((Lu Q-Y)) | title=Antibacterial Compounds from ''Glycyrrhiza uralensis'' | journal= Journal of Natural Products | volume=69| issue=1 | year=2006 | pages=121–124 | doi=10.1021/np058069d | pmid= 16441081| citeseerx=10.1.1.552.7335 }}</ref> In one study, the strongest antibacterial activity was observed against ''[[Streptococcus mutans]]'', an organism known to cause tooth decay in humans.<ref name = He/>


==References==
==References==
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[[Category:Pterocarpans]]
[[Category:Pterocarpans]]
[[Category:Antibiotics]]
[[Category:Antibiotics]]
[[Category:Chromenes]]
[[Category:Hydroxyarenes]]
[[Category:Methoxy compounds]]



{{Natural-phenol-stub}}
{{aromatic-stub}}

Latest revision as of 12:01, 21 October 2024

Glycyrrhizol A
Names
Preferred IUPAC name
1-Methoxy-2,8-bis(3-methylbut-2-en-1-yl)-6H-[1]benzofuro[3,2-c] [1]benzopyran-3,9-diol
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
UNII
  • InChI=1S/C26H28O5/c1-14(2)6-8-16-10-18-19-13-30-23-12-21(28)17(9-7-15(3)4)25(29-5)24(23)26(19)31-22(18)11-20(16)27/h6-7,10-12,27-28H,8-9,13H2,1-5H3 checkY
    Key: CBPFOSMNDISZLV-UHFFFAOYSA-N checkY
  • InChI=1/C26H28O5/c1-14(2)6-8-16-10-18-19-13-30-23-12-21(28)17(9-7-15(3)4)25(29-5)24(23)26(19)31-22(18)11-20(16)27/h6-7,10-12,27-28H,8-9,13H2,1-5H3
    Key: CBPFOSMNDISZLV-UHFFFAOYAJ
  • o2c1c(cc(c(O)c1)C\C=C(/C)C)c3c2c4c(OC)c(c(O)cc4OC3)C\C=C(/C)C
Properties
C26H28O5
Molar mass 420.50 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Glycyrrhizol A is a prenylated pterocarpan and an isoflavonoid derivative. It is a compound isolated from the root of the Chinese licorice plant (Glycyrrhiza uralensis).[citation needed]

It may has in vitro antibacterial properties.[1] In one study, the strongest antibacterial activity was observed against Streptococcus mutans, an organism known to cause tooth decay in humans.[1]

References

[edit]
  1. ^ a b He J, Chen L, Shi W, Lu Q-Y (2006). "Antibacterial Compounds from Glycyrrhiza uralensis". Journal of Natural Products. 69 (1): 121–124. CiteSeerX 10.1.1.552.7335. doi:10.1021/np058069d. PMID 16441081.


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