Lymph: Difference between revisions
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| Latin = lympha |
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| Image = Illu lymph capillary.png |
| Image = Illu lymph capillary.png |
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| Caption = Diagram showing the formation of lymph from [[interstitial fluid]] (labeled here as "Tissue fluid"). Note how the tissue fluid is entering the blind ends of [[lymph capillaries]] (shown as deep green arrows) |
| Caption = Diagram showing the formation of lymph from [[interstitial fluid]] (labeled here as "Tissue fluid"). Note how the tissue fluid is entering the blind ends of [[lymph capillaries]] (shown as deep green arrows). |
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'''Lymph''' ( |
'''Lymph''' ({{etymology|la|{{Wikt-lang|la|lympha}}|water}})<ref>{{cite Merriam-Webster|lymph |access-date=29 May 2010}}</ref> is the fluid that flows through the [[lymphatic system]], a system composed of [[lymph vessel]]s (channels) and intervening [[lymph node]]s whose function, like the [[venous system]], is to return fluid from the tissues to be recirculated. At the origin of the fluid-return process, [[interstitial fluid]]—the fluid between the cells in all [[body tissue]]s<ref>[http://www.anaesthesiamcq.com/FluidBook/fl2_1.php Fluid Physiology: 2.1 Fluid Compartments]</ref>—enters the [[lymph capillary|lymph capillaries]]. This lymphatic fluid is then transported via progressively larger lymphatic vessels through lymph nodes, where substances are removed by tissue [[lymphocyte]]s and circulating lymphocytes are added to the fluid, before emptying ultimately into the right or the left [[subclavian vein]], where it mixes with central [[venous blood]]. |
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Because it is derived from interstitial fluid, with which blood and surrounding cells continually exchange substances, lymph undergoes continual change in composition. It is generally similar to [[blood plasma]], which is the fluid component of blood. Lymph returns [[protein]]s and excess interstitial fluid to the [[bloodstream]]. Lymph also transports fats from the [[digestive system]] (beginning in the [[lacteal]]s) to the blood via [[chylomicron]]s. |
Because it is derived from interstitial fluid, with which blood and surrounding cells continually exchange substances, lymph undergoes continual change in composition. It is generally similar to [[blood plasma]], which is the fluid component of blood. Lymph returns [[protein]]s and excess interstitial fluid to the [[bloodstream]]. Lymph also transports fats from the [[digestive system]] (beginning in the [[lacteal]]s) to the blood via [[chylomicron]]s. |
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| year=2012 | page=604 | publisher=Wolters Kluwer Health |
| year=2012 | page=604 | publisher=Wolters Kluwer Health |
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| isbn=9781451179705 |
| isbn=9781451179705 |
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| url=https:// |
| url=https://books.google.com/books?id=Z3VG56tZkQoC&pg=PT604 }}</ref>) The lymph when formed is a watery clear liquid with the same composition as the interstitial fluid. However, as it flows through the lymph nodes it comes in contact with blood, and tends to accumulate more cells (particularly, lymphocytes) and proteins.<ref name=sloop>{{cite journal |last= Sloop|first= Charles H.|author2=Ladislav Dory |author3=Paul S. Roheim |date=March 1987|title=Interstitial fluid lipoproteins|journal= Journal of Lipid Research|volume= 28|issue= 3|pages= 225–237|doi= 10.1016/S0022-2275(20)38701-0|url= http://www.jlr.org/cgi/reprint/28/3/225.pdf|access-date=7 July 2008 |pmid= 3553402|doi-access= free}}</ref> |
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==Functions== |
==Functions== |
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Tubular vessels transport lymph back to the blood, ultimately replacing the volume lost during the formation of the interstitial fluid. These channels are the lymphatic channels, or simply ''lymphatics''.<ref>{{cite web |url=http://www.medterms.com/script/main/art.asp?articlekey=4217 |title=Definition of lymphatics |access-date=6 July 2008 |work=Webster's New World Medical Dictionary |publisher= MedicineNet.com}}</ref> |
Tubular vessels transport lymph back to the blood, ultimately replacing the volume lost during the formation of the interstitial fluid. These channels are the lymphatic channels, or simply ''lymphatics''.<ref>{{cite web |url=http://www.medterms.com/script/main/art.asp?articlekey=4217 |title=Definition of lymphatics |access-date=6 July 2008 |work=Webster's New World Medical Dictionary |publisher= MedicineNet.com}}</ref> |
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Unlike the cardiovascular system, the lymphatic system is not closed. In some amphibian and [[reptile|reptilian]] species, the lymphatic system has central pumps, called [[lymph heart]]s, which typically exist in pairs,<ref name="Hedrick">{{cite journal | last1=Hedrick | first1=Michael S. | last2=Hillman | first2=Stanley S. | last3=Drewes | first3=Robert C. | last4=Withers | first4=Philip C. | title=Lymphatic regulation in nonmammalian vertebrates | journal=Journal of Applied Physiology | volume=115 | issue=3 | date=1 July 2013 | issn=8750-7587 | doi=10.1152/japplphysiol.00201.2013 | pages=297–308|pmid=23640588|url=https://journals.physiology.org/doi/full/10.1152/japplphysiol.00201.2013}}</ref><ref>{{cite journal |last1=Banda |first1=Chihena H. |last2=Shiraishi |first2=Makoto |last3=Mitsui |first3=Kohei |last4=Okada |first4=Yoshimoto |last5=Danno |first5=Kanako |last6=Ishiura |first6=Ryohei |last7=Maemura |first7=Kaho |last8=Chiba |first8=Chikafumi |last9=Mizoguchi |first9=Akira |last10=Imanaka-Yoshida |first10=Kyoko |last11=Maruyama |first11=Kazuaki |last12=Narushima |first12=Mitsunaga |title=Structural and functional analysis of the newt lymphatic system |journal=Scientific Reports |date=27 April 2023 |volume=13 |issue=1 |doi=10.1038/s41598-023-34169-w |pmid=37106059 |
Unlike the cardiovascular system, the lymphatic system is not closed. In some amphibian and [[reptile|reptilian]] species, the lymphatic system has central pumps, called [[lymph heart]]s, which typically exist in pairs,<ref name="Hedrick">{{cite journal | last1=Hedrick | first1=Michael S. | last2=Hillman | first2=Stanley S. | last3=Drewes | first3=Robert C. | last4=Withers | first4=Philip C. | title=Lymphatic regulation in nonmammalian vertebrates | journal=Journal of Applied Physiology | volume=115 | issue=3 | date=1 July 2013 | issn=8750-7587 | doi=10.1152/japplphysiol.00201.2013 | pages=297–308|pmid=23640588|url=https://journals.physiology.org/doi/full/10.1152/japplphysiol.00201.2013}}</ref><ref>{{cite journal |last1=Banda |first1=Chihena H. |last2=Shiraishi |first2=Makoto |last3=Mitsui |first3=Kohei |last4=Okada |first4=Yoshimoto |last5=Danno |first5=Kanako |last6=Ishiura |first6=Ryohei |last7=Maemura |first7=Kaho |last8=Chiba |first8=Chikafumi |last9=Mizoguchi |first9=Akira |last10=Imanaka-Yoshida |first10=Kyoko |last11=Maruyama |first11=Kazuaki |last12=Narushima |first12=Mitsunaga |title=Structural and functional analysis of the newt lymphatic system |journal=Scientific Reports |date=27 April 2023 |volume=13 |issue=1 |page=6902 |doi=10.1038/s41598-023-34169-w |pmid=37106059 |language=en |issn=2045-2322|doi-access=free |pmc=10140069 }}</ref> but humans and other mammals do not have a central lymph pump. Lymph transport is slow and sporadic.<ref name=Hedrick/> Despite low pressure, lymph movement occurs due to [[peristalsis]] (propulsion of the lymph due to alternate contraction and relaxation of [[smooth muscle]] tissue), valves, and compression during contraction of adjacent skeletal muscle and [[arterial]] [[pulse|pulsation]].<ref name=Shayan2006>{{cite journal |author1=Shayan, Ramin |author2=Achen, Marc G. |author3=Stacker, Steven A. | year = 2006 | title = Lymphatic vessels in cancer metastasis: bridging the gaps | volume = 27 | issue = 9 | pages = 1729–38 | doi = 10.1093/carcin/bgl031 | pmid = 16597644 | journal = Carcinogenesis | doi-access = free }}</ref> |
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Lymph that enters the lymph vessels from the interstitial spaces usually does not flow backwards along the vessels because of the presence of valves. If excessive [[hydrostatic pressure]] develops within the lymph vessels, though, some fluid can leak back into the interstitial spaces and contribute to formation of [[edema]]. |
Lymph that enters the lymph vessels from the interstitial spaces usually does not flow backwards along the vessels because of the presence of valves. If excessive [[hydrostatic pressure]] develops within the lymph vessels, though, some fluid can leak back into the interstitial spaces and contribute to formation of [[edema]]. |
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In 1913, E. Steinhardt, C. Israeli, and R. A. Lambert grew [[vaccinia]] virus in fragments of [[tissue culture]] from guinea pig [[cornea]] grown in lymph.<ref>Steinhardt, E; Israeli, C; and Lambert, R.A. (1913) "Studies on the cultivation of the virus of vaccinia" ''J. Inf Dis. 13, 294–300</ref> |
In 1913, E. Steinhardt, C. Israeli, and R. A. Lambert grew [[vaccinia]] virus in fragments of [[tissue culture]] from guinea pig [[cornea]] grown in lymph.<ref>Steinhardt, E; Israeli, C; and Lambert, R.A. (1913) "Studies on the cultivation of the virus of vaccinia" ''J. Inf Dis. 13, 294–300</ref> |
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==After death== |
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Decomposing corpses release lymph if the dead body is not preserved properly. A Thai religious cult attracted widespread disgust in 2022 for the unusual practices of its adherents, which included washing their faces in lymph that drained out of holes drilled into the coffins of dead followers.<ref name=lymph>{{cite web|url=https://www.vice.com/en/article/n7n8ed/religious-cult-eats-poop|title=Disturbing Details Keep Emerging About This Bizarre Poop-Eating Cult}}</ref> |
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==References== |
==References== |
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Latest revision as of 17:34, 28 October 2024
| Lymph | |
|---|---|
 Diagram showing the formation of lymph from interstitial fluid (labeled here as "Tissue fluid"). Note how the tissue fluid is entering the blind ends of lymph capillaries (shown as deep green arrows). | |
| Details | |
| System | Lymphatic system |
| Source | Formed from interstitial fluid |
| Identifiers | |
| Latin | lympha |
| MeSH | D008196 |
| TA98 | A12.0.00.043 |
| TA2 | 3893 |
| FMA | 9671 |
| Anatomical terminology | |
Lymph (from Latin lympha 'water')[1] is the fluid that flows through the lymphatic system, a system composed of lymph vessels (channels) and intervening lymph nodes whose function, like the venous system, is to return fluid from the tissues to be recirculated. At the origin of the fluid-return process, interstitial fluid—the fluid between the cells in all body tissues[2]—enters the lymph capillaries. This lymphatic fluid is then transported via progressively larger lymphatic vessels through lymph nodes, where substances are removed by tissue lymphocytes and circulating lymphocytes are added to the fluid, before emptying ultimately into the right or the left subclavian vein, where it mixes with central venous blood.
Because it is derived from interstitial fluid, with which blood and surrounding cells continually exchange substances, lymph undergoes continual change in composition. It is generally similar to blood plasma, which is the fluid component of blood. Lymph returns proteins and excess interstitial fluid to the bloodstream. Lymph also transports fats from the digestive system (beginning in the lacteals) to the blood via chylomicrons.
Bacteria may enter the lymph channels and be transported to lymph nodes, where the bacteria are destroyed. Metastatic cancer cells can also be transported via lymph.
Etymology
[edit]The word lymph is derived from the name of the ancient Roman deity of fresh water, Lympha.
Structure
[edit]
Lymph has a composition similar but not identical to that of blood plasma. Lymph that leaves a lymph node is richer in lymphocytes than blood plasma is. The lymph formed in the human digestive system called chyle is rich in triglycerides (fat), and looks milky white because of its lipid content.
Development
[edit]
Blood supplies nutrients and important metabolites to the cells of a tissue and collects back the waste products they produce, which requires exchange of respective constituents between the blood and tissue cells. This exchange is not direct, but instead occurs through an intermediary called interstitial fluid, which occupies the spaces between cells. As the blood and the surrounding cells continually add and remove substances from the interstitial fluid, its composition continually changes. Water and solutes can pass between the interstitial fluid and blood via diffusion across gaps in capillary walls called intercellular clefts; thus, the blood and interstitial fluid are in dynamic equilibrium with each other.[3]
Interstitial fluid forms at the arterial (coming from the heart) end of capillaries because of the higher pressure of blood compared to veins, and most of it returns to its venous ends and venules; the rest (up to 10%) enters the lymph capillaries as lymph.[4] (Prior to entry, this fluid is referred to as the lymph obligatory load, or LOL, as the lymphatic system is effectively "obliged" to return it to the cardiovascular network.[5]) The lymph when formed is a watery clear liquid with the same composition as the interstitial fluid. However, as it flows through the lymph nodes it comes in contact with blood, and tends to accumulate more cells (particularly, lymphocytes) and proteins.[6]
Functions
[edit]Components
[edit]Lymph returns proteins and excess interstitial fluid to the bloodstream. Lymph may pick up bacteria and transport them to lymph nodes, where the bacteria are destroyed. Metastatic cancer cells can also be transported via lymph. Lymph also transports fats from the digestive system (beginning in the lacteals) to the blood via chylomicrons.
Circulation
[edit]Tubular vessels transport lymph back to the blood, ultimately replacing the volume lost during the formation of the interstitial fluid. These channels are the lymphatic channels, or simply lymphatics.[7]
Unlike the cardiovascular system, the lymphatic system is not closed. In some amphibian and reptilian species, the lymphatic system has central pumps, called lymph hearts, which typically exist in pairs,[8][9] but humans and other mammals do not have a central lymph pump. Lymph transport is slow and sporadic.[8] Despite low pressure, lymph movement occurs due to peristalsis (propulsion of the lymph due to alternate contraction and relaxation of smooth muscle tissue), valves, and compression during contraction of adjacent skeletal muscle and arterial pulsation.[10]
Lymph that enters the lymph vessels from the interstitial spaces usually does not flow backwards along the vessels because of the presence of valves. If excessive hydrostatic pressure develops within the lymph vessels, though, some fluid can leak back into the interstitial spaces and contribute to formation of edema.
The flow of lymph in the thoracic duct in an average resting person usually approximates 100ml per hour. Accompanied by another ~25ml per hour in other lymph vessels, the total lymph flow in the body is about 4 to 5 litres per day. This can be elevated several fold while exercising. It is estimated that without lymphatic flow, the average resting person would die within 24 hours.[11]
Clinical significance
[edit]![[icon]](/enwiki/wiki/File:Wiki_letter_w_cropped.svg){kind=small} | This section needs expansion. You can help by adding to it. (March 2018) |
Histopathological examination of the lymph system is used as a screening tool for immune system analysis in conjunction with pathological changes in other organ systems and clinical pathology to assess disease status.[12] Although histological assessment of the lymph system does not directly measure immune function, it can be combined with identification of chemical biomarkers to determine underlying changes in the diseased immune system.[13]
As a growth medium
[edit]In 1907 the zoologist Ross Granville Harrison demonstrated the growth of frog nerve cell processes in a medium of clotted lymph. It is made up of lymph nodes and vessels.
In 1913, E. Steinhardt, C. Israeli, and R. A. Lambert grew vaccinia virus in fragments of tissue culture from guinea pig cornea grown in lymph.[14]
References
[edit]- ^ "lymph". Merriam-Webster.com Dictionary. Merriam-Webster. Retrieved 29 May 2010.
- ^ Fluid Physiology: 2.1 Fluid Compartments
- ^ "The Lymphatic System". Human Anatomy (Gray's Anatomy). Retrieved 12 October 2012.
- ^ Warwick, Roger; Peter L. Williams (1973) [1858]. "Angiology (Chapter 6)". Gray's anatomy. illustrated by Richard E. M. Moore (Thirty-fifth ed.). London: Longman. pp. 588–785.
- ^ Archer, Pat; Nelson, Lisa A. (2012). Applied Anatomy & Physiology for Manual Therapists. Wolters Kluwer Health. p. 604. ISBN 9781451179705.
- ^ Sloop, Charles H.; Ladislav Dory; Paul S. Roheim (March 1987). "Interstitial fluid lipoproteins" (PDF). Journal of Lipid Research. 28 (3): 225–237. doi:10.1016/S0022-2275(20)38701-0. PMID 3553402. Retrieved 7 July 2008.
- ^ "Definition of lymphatics". Webster's New World Medical Dictionary. MedicineNet.com. Retrieved 6 July 2008.
- ^ a b Hedrick, Michael S.; Hillman, Stanley S.; Drewes, Robert C.; Withers, Philip C. (1 July 2013). "Lymphatic regulation in nonmammalian vertebrates". Journal of Applied Physiology. 115 (3): 297–308. doi:10.1152/japplphysiol.00201.2013. ISSN 8750-7587. PMID 23640588.
- ^ Banda, Chihena H.; Shiraishi, Makoto; Mitsui, Kohei; Okada, Yoshimoto; Danno, Kanako; Ishiura, Ryohei; Maemura, Kaho; Chiba, Chikafumi; Mizoguchi, Akira; Imanaka-Yoshida, Kyoko; Maruyama, Kazuaki; Narushima, Mitsunaga (27 April 2023). "Structural and functional analysis of the newt lymphatic system". Scientific Reports. 13 (1): 6902. doi:10.1038/s41598-023-34169-w. ISSN 2045-2322. PMC 10140069. PMID 37106059.
- ^ Shayan, Ramin; Achen, Marc G.; Stacker, Steven A. (2006). "Lymphatic vessels in cancer metastasis: bridging the gaps". Carcinogenesis. 27 (9): 1729–38. doi:10.1093/carcin/bgl031. PMID 16597644.
- ^ Guyton and Hall Textbook of Medical Physiology. Saunders. 2010. pp. 186, 187. ISBN 978-1416045748.
- ^ Elmore, Susan A. (16 November 2011). "Enhanced histopathology of the immune system". Toxicologic Pathology. 40 (2): 148–156. doi:10.1177/0192623311427571. ISSN 0192-6233. PMC 3465566. PMID 22089843.
- ^ Elmore, Susan A. (2018). "Enhanced Histopathology Evaluation of Lymphoid Organs". Immunotoxicity Testing. Methods in Molecular Biology. Vol. 1803. pp. 147–168. doi:10.1007/978-1-4939-8549-4_10. ISBN 978-1-4939-8548-7. ISSN 1064-3745. PMID 29882138.
- ^ Steinhardt, E; Israeli, C; and Lambert, R.A. (1913) "Studies on the cultivation of the virus of vaccinia" J. Inf Dis. 13, 294–300
External links
[edit]
Media related to Lymph fluid at Wikimedia Commons
