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'''Michael Paul Snyder''' is an American [[Genomics|genomicist]] and the Stanford W. Ascherman Professor,<ref name=StanfordEdu>{{cite web |url=https://profiles.stanford.edu/michael-snyder |title=Michael Snyder, Ph.D., STANFORD W. ASCHERMAN PROFESSOR OF GENETICS |last= |first= |date=20 August 2015 |website= Stanford profiles|access-date=19 April 2022}}</ref><ref name="auto7">{{Cite web|url=https://genestogenomes.org/snyder-beadle/|title=Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award!|date=2 April 2019|accessdate=16 May 2022}}</ref> and since 2009, chair of [[genetics]] and director of genomics and personalized [[medicine]] at [[Stanford University School of Medicine|Stanford University]].<ref name=StanfordEdu/> He is the former director of the [[Yale University|Yale]] Center for [[Genomics]] and Proteomics.<ref name="auto5"/> He was elected to the [[American Academy of Arts and Sciences]] in 2015.<ref name="auto3">{{Cite web |date=13 September 2023 |title=Michael Snyder |url=https://www.amacad.org/person/michael-snyder |website=American Academy of Arts and Sciences}}</ref> During his tenure as chair of the department at Stanford, ''[[U.S. News & World Report]]'' has ranked [[Stanford University]] first or tied for first in genetics, genomics and bioinformatics.<ref>{{cite web |title=Best Genetics Graduate Programs - US News Rankings |url=https://www.usnews.com/best-graduate-schools/top-science-schools/genetics-rankings |website=[[U.S. News & World Report]] |archive-url=https://web.archive.org/web/20230407171846/https://www.usnews.com/best-graduate-schools/top-science-schools/genetics-rankings |archive-date=2023-04-07 |url-status=live}}</ref>
'''Michael Paul Snyder''' is an American [[Genomics|genomicist]], a Stanford School of Medicine professor, and chair of [[genetics]] and director of genomics and personalized [[medicine]] at [[Stanford University School of Medicine|Stanford University]].<ref name=StanfordEdu>{{cite web |url=https://profiles.stanford.edu/michael-snyder |title=Michael Snyder, Ph.D., STANFORD W. ASCHERMAN PROFESSOR OF GENETICS |last= |first= |date=20 August 2015 |website= Stanford profiles|access-date=19 April 2022}}</ref><ref name="auto7">{{Cite web|url=https://genestogenomes.org/snyder-beadle/|title=Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award!|date=2 April 2019|accessdate=16 May 2022}}</ref>


⚫
Snyder's research has focused on "[[omics]]", the study of genomes, transcriptomes, proteomes, and other "-omes". His lab's work has specifically contributed to understanding the genomes and transcriptomes of first yeast and now humans. The Snyder lab pioneered the use of [[Multiomics|multi-omic]] longitudinal profiling to track health.<ref>{{cite journal |vauthors=Zhou W, Sailani MR, Contrepois K, Zhou Y, Ahadi S, Leopold SR, Zhang MJ, Rao V, Avina M, Mishra T, Johnson J, Lee-McMullen B, Chen S, Metwally AA, Tran TD, Nguyen H, Zhou X, Albright B, Hong BY, Petersen L, Bautista E, Hanson B, Chen L, Spakowicz D, Bahmani A, Salins D, Leopold B, Ashland M, Dagan-Rosenfeld O, Rego S, Limcaoco P, Colbert E, Allister C, Perelman D, Craig C, Wei E, Chaib H, Hornburg D, Dunn J, Liang L, Rose SM, Kukurba K, Piening B, Rost H, Tse D, McLaughlin T, Sodergren E, Weinstock GM, Snyder M|display-authors=6 |title=Longitudinal multi-omics of host-microbe dynamics in prediabetes |journal=Nature |volume=569 |issue=7758 |pages=663–71 |date=May 2019 |pmid=31142858 |pmc=6666404 |doi=10.1038/s41586-019-1236-x |bibcode=2019Natur.569..663Z |url=}}</ref><ref>{{Cite web |url=https://www.thermofisher.com/us/en/home/global/forms/industrial/multi-omics-redefine-precision-health.html|title = How Multi-Omics Profiling Can Redefine Precision Health and Medicine - US|website=ThermoFisher Scientific}}</ref>
Snyder has co-founded companies in [[genetics]], genomics, and personalized medicine. Snyder has been a principal investigator of the [[ENCODE]] project since its inception in 2003,<ref>{{Cite journal|doi = 10.1038/s41586-020-2449-8|title = Perspectives on ENCODE|year = 2020|last1 = Abascal|first1 = Federico|last2 = Acosta|first2 = Reyes|last3 = Addleman|first3 = Nicholas J.|last4 = Adrian|first4 = Jessika|last5 = Afzal|first5 = Veena|last6 = Aken|first6 = Bronwen|last7 = Akiyama|first7 = Jennifer A.|last8 = Jammal|first8 = Omar Al|last9 = Amrhein|first9 = Henry|last10 = Anderson|first10 = Stacie M.|last11 = Andrews|first11 = Gregory R.|last12 = Antoshechkin|first12 = Igor|last13 = Ardlie|first13 = Kristin G.|last14 = Armstrong|first14 = Joel|last15 = Astley|first15 = Matthew|last16 = Banerjee|first16 = Budhaditya|last17 = Barkal|first17 = Amira A.|last18 = Barnes|first18 = If H. A.|last19 = Barozzi|first19 = Iros|last20 = Barrell|first20 = Daniel|last21 = Barson|first21 = Gemma|last22 = Bates|first22 = Daniel|last23 = Baymuradov|first23 = Ulugbek K.|last24 = Bazile|first24 = Cassandra|last25 = Beer|first25 = Michael A.|last26 = Beik|first26 = Samantha|last27 = Bender|first27 = M. A.|last28 = Bennett|first28 = Ruth|last29 = Bouvrette|first29 = Louis Philip Benoit|last30 = Bernstein|first30 = Bradley E.|display-authors=6|journal = Nature|volume = 583|issue = 7818|pages = 693–98|pmid = 32728248|pmc = 7410827|bibcode = 2020Natur.583..693E}}</ref> and co-director of the CIRM Center for Stem Cell Genomics<ref>{{Cite web|url=https://www.cirm.ca.gov/researchers/genomics-initiative/about|title = The CIRM Center of Excellence in Stem Cell Genomics (CESCG)|date = 26 February 2015}}</ref> and director of the Center for Genome of Gene Regulation.<ref>{{cite web |url=http://www.genomacrg.cl/ |title=Home |website=genomacrg.cl}}</ref>

⚫
Snyder pioneered the use of multi-omic longitudinal profiling to track health.<ref>{{cite journal |vauthors=Zhou W, Sailani MR, Contrepois K, Zhou Y, Ahadi S, Leopold SR, Zhang MJ, Rao V, Avina M, Mishra T, Johnson J, Lee-McMullen B, Chen S, Metwally AA, Tran TD, Nguyen H, Zhou X, Albright B, Hong BY, Petersen L, Bautista E, Hanson B, Chen L, Spakowicz D, Bahmani A, Salins D, Leopold B, Ashland M, Dagan-Rosenfeld O, Rego S, Limcaoco P, Colbert E, Allister C, Perelman D, Craig C, Wei E, Chaib H, Hornburg D, Dunn J, Liang L, Rose SM, Kukurba K, Piening B, Rost H, Tse D, McLaughlin T, Sodergren E, Weinstock GM, Snyder M|display-authors=6 |title=Longitudinal multi-omics of host-microbe dynamics in prediabetes |journal=Nature |volume=569 |issue=7758 |pages=663–71 |date=May 2019 |pmid=31142858 |pmc=6666404 |doi=10.1038/s41586-019-1236-x |bibcode=2019Natur.569..663Z |url=}}</ref><ref>{{Cite web |url=https://www.thermofisher.com/us/en/home/global/forms/industrial/multi-omics-redefine-precision-health.html|title = How Multi-Omics Profiling Can Redefine Precision Health and Medicine - US|website=ThermoFisher Scientific}}</ref>


== Early life and education ==
== Early life and education ==
Snyder was born in 1955 and grew up outside of [[Pottstown, Pennsylvania]].<ref name="auto1">{{Cite web|url=https://ctcase.org/member/michael-p-snyder/|title=Michael P. Snyder|accessdate=16 May 2022}}</ref><ref>{{Cite news|url=https://www.wsj.com/articles/BL-HEB-49289|title=What Happens When One Man's Genome Is Revealed|first=Amy Dockser|last=Marcus|newspaper=Wall Street Journal |date=14 May 2012|accessdate=16 May 2022|via=www.wsj.com}}</ref> His father, Kermit Snyder, was an accountant and his mother, Phyllis Snyder, was an elementary school teacher. Snyder attended Owen J Roberts High school in Pottstown. He received a BA in chemistry and biology from the [[University of Rochester]], NY on a scholarship.<ref name="auto10">{{Cite news|url=https://psmag.com/social-justice/making-it-personal-geneticist-michael-snyder-puts-a-face-to-personalized-medicine-57554|title=Making It Personal: Geneticist Michael Snyder Puts a Face on Personalized Medicine|first=Kayt|last=Sukel|website=Pacific Standard|accessdate=16 May 2022}}</ref> He went on to receive a PhD in biology from the [[California Institute of Technology]], where he trained in the laboratory of [[Norman Davidson (biologist)|Norman Davidson]].<ref name=Beadle>{{cite web |url=https://genestogenomes.org/snyder-beadle/ |title=Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award! |last=Schmidt |first=Silke |date=9 April 2019 |website=Genetics Society of America |access-date=8 February 2021}}</ref> Snyder completed his postdoctoral training at [[Stanford University School of Medicine]] in the laboratory of [[Ronald W. Davis]].<ref name=Beadle/> There he was involved in several projects including establishment of successful cloning of genes using antibodies.<ref name="auto3" />
Snyder was born in 1955 and grew up outside of [[Pottstown, Pennsylvania]].<ref name="auto1">{{Cite web|url=https://ctcase.org/member/michael-p-snyder/|title=Michael P. Snyder|accessdate=16 May 2022}}</ref><ref>{{Cite news |last=Marcus |first=Amy Dockser |date=14 May 2012 |title=What Happens When One Man's Genome Is Revealed |url=https://www.wsj.com/articles/BL-HEB-49289 |archive-url=https://web.archive.org/web/20220420041348/https://www.wsj.com/articles/BL-HEB-49289 |archive-date=2022-04-20 |accessdate=16 May 2022 |newspaper=Wall Street Journal |via=www.wsj.com}}</ref> His father, Kermit Snyder, was an accountant and his mother, Phyllis Snyder, was an elementary school teacher. Snyder attended Owen J. Roberts High school in Pottstown. He received a BA in chemistry and biology from the [[University of Rochester]], NY and went on to receive a PhD in biology from the [[California Institute of Technology]], where he trained in the laboratory of [[Norman Davidson (biologist)|Norman Davidson]].<ref name="auto10">{{Cite news |last=Sukel |first=Kayt |title=Making It Personal: Geneticist Michael Snyder Puts a Face on Personalized Medicine |url=https://psmag.com/social-justice/making-it-personal-geneticist-michael-snyder-puts-a-face-to-personalized-medicine-57554 |accessdate=16 May 2022 |website=Pacific Standard}}</ref> <ref name=Beadle>{{cite web |url=https://genestogenomes.org/snyder-beadle/ |title=Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award! |last=Schmidt |first=Silke |date=9 April 2019 |website=Genetics Society of America |access-date=8 February 2021}}</ref> Snyder completed his postdoctoral training at [[Stanford University School of Medicine]] in the laboratory of [[Ronald W. Davis]].<ref name=Beadle/>


== Career ==
== Career and appointments ==
Snyder worked at [[Yale University]] in 1986 as an assistant professor in the department of biology,<ref name="auto10"/> and was granted tenure in 1994. In 1998, the department of biology split and Snyder served as chair of the new molecular, cellular and developmental biology (MCDB) department until 2004.<ref name=Beadle/> His laboratory worked on chromosome segregation and cell polarity, and discovered a number of genes involved in these processes.<ref>{{cite journal |vauthors=Page BD, Snyder M |title=CIK1: a developmentally regulated spindle pole body-associated protein important for microtubule functions in Saccharomyces cerevisiae |journal=Genes Dev |volume=6 |issue=8 |pages=1414–29 |date=August 1992 |pmid=1644287 |doi=10.1101/gad.6.8.1414 |s2cid=24949358 |url=|doi-access=free }}</ref><ref name="auto8">{{cite journal |vauthors=Roemer T, Madden K, Chang J, Snyder M |title=Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein |journal=Genes Dev |volume=10 |issue=7 |pages=777–93 |date=April 1996 |pmid=8846915 |doi=10.1101/gad.10.7.777 |url=|doi-access=free }}</ref>
Snyder started at [[Yale University]] in 1986 as an assistant professor in the department of biology.<ref name="auto10"/> He was granted tenure at Yale in 1994. In 1998, the department of biology split; Snyder served as chair of the new molecular, cellular and developmental biology (MCDB) department until 2004 as well as the director for the Center for [[Genomics]] and Proteomics.<ref name="auto5" /><ref name=Beadle/> His laboratory worked on chromosome segregation and cell polarity, which led to the discovery of a number of genes involved in these processes.<ref>{{cite journal |vauthors=Page BD, Snyder M |title=CIK1: a developmentally regulated spindle pole body-associated protein important for microtubule functions in Saccharomyces cerevisiae |journal=Genes Dev |volume=6 |issue=8 |pages=1414–29 |date=August 1992 |pmid=1644287 |doi=10.1101/gad.6.8.1414 |s2cid=24949358 |url=|doi-access=free }}</ref><ref name="auto8">{{cite journal |vauthors=Roemer T, Madden K, Chang J, Snyder M |title=Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein |journal=Genes Dev |volume=10 |issue=7 |pages=777–93 |date=April 1996 |pmid=8846915 |doi=10.1101/gad.10.7.777 |url=|doi-access=free }}</ref>


In 2009, Snyder moved to [[Stanford University]] where he chaired the genetics department and directed the Center for Genomics and Personalized Medicine.<ref name="auto7" /><ref name="Beadle" /> Snyder has served as principal investigator of the Center of Excellence in the Genome Sciences (CEGS) from 2001 to 2011 and is currently co-director of the CIRM Center for Stem Cell Genomics,<ref>{{Cite web|url=https://www.cirm.ca.gov/researchers/genomics-initiative/about|title=The CIRM Center of Excellence in Stem Cell Genomics (CESCG)|date=26 February 2015|website=California's Stem Cell Agency|accessdate=16 May 2022}}</ref> as well as director for the Center for Genome of Gene Regulation.<ref>{{Cite web|url=http://med.stanford.edu/news/all-news/2015/02/snyder-awarded-7-million-from-genome-institute.html|title=Snyder awarded $7.1 million from genome institute|website=News Center|accessdate=16 May 2022}}</ref>
His laboratory proposed the first models by which [[Eukaryote|eukaryotes]] select sites of cell growth.<ref>{{cite journal |vauthors=Snyder M, Gehrung S, Page BD |title=Studies concerning the temporal and genetic control of cell polarity in Saccharomyces cerevisiae |journal=J Cell Biol |volume=114 |issue=3 |pages=515–32 |date=August 1991 |pmid=1860883 |pmc=2289092 |doi=10.1083/jcb.114.3.515 |url=}}</ref><ref name="auto8"/>


In 2009, Snyder chaired the genetics department at [[Stanford University]] and directed the Center for Genomics and Personalized Medicine.<ref name="auto7" /><ref name="Beadle" /> Snyder was principal investigator of the Center of Excellence in the Genome Sciences (CEGS) from 2001 to 2011, was principal investigator for NIH Training Grants in Genomics and Proteomics (first at Yale, now at Stanford) from 2004, and is co-director of the CIRM Center for Stem Cell Genomics<ref>{{Cite web|url=https://www.cirm.ca.gov/researchers/genomics-initiative/about|title=The CIRM Center of Excellence in Stem Cell Genomics (CESCG)|date=26 February 2015|website=California's Stem Cell Agency|accessdate=16 May 2022}}</ref> and director for the Center for Genome of Gene Regulation.<ref>{{Cite web|url=http://med.stanford.edu/news/all-news/2015/02/snyder-awarded-7-million-from-genome-institute.html|title=Snyder awarded $7.1 million from genome institute|website=News Center|accessdate=16 May 2022}}</ref> Snyder was president of the US [[Human Proteome Organization]] from 2006 to 2008, and the international [[Human Proteome Organization]] from 2017 to 2018. He currently leads the National Institutes of Health's Encyclopedia of DNA Elements ([[ENCODE]])'s production center for mapping regulatory regions of the human genome.<ref>{{cite web | url=https://reporter.nih.gov/project-details/9247694 | title=RePORT ⟩ RePORTER }}</ref>
Snyder was president of the US [[Human Proteome Organization]] from 2006 to 2008, elected to the [[American Academy of Arts and Sciences]] in 2015, and president of the international [[Human Proteome Organization]] from 2017 to 2018.<ref name="auto3">{{Cite web |date=13 September 2023 |title=Michael Snyder |url=https://www.amacad.org/person/michael-snyder |website=American Academy of Arts and Sciences}}</ref> He currently leads the National Institutes of Health's Encyclopedia of DNA Elements ([[ENCODE]])'s production center for mapping regulatory regions of the human genome.<ref>{{cite web | url=https://reporter.nih.gov/project-details/9247694 | title=RePORT ⟩ RePORTER }}</ref>


Snyder has co-founded biotechnology companies, including Personalis,<ref name="auto9">{{Cite news |last=Eisenberg |first=Anne |date=2 June 2012 |title=A Geneticist's Research Turns Personal |url=https://www.nytimes.com/2012/06/03/business/geneticists-research-finds-his-own-diabetes.html |accessdate=16 May 2022 |newspaper=The New York Times}}</ref> SensOmics,<ref>{{Cite web|url=https://www.sensomics.com/|title=SensOmics, See the Unseen|website=SensOmics, See the Unseen}}</ref> Qbio,<ref name="auto">{{Cite news |last=Maxted |first=Anna |title=What's your ageing type? The four ways we grow old |url=https://www.thetimes.co.uk/article/whats-your-ageing-type-the-four-ways-we-grow-old-bhd2lrscp |accessdate=16 May 2022 |via=www.thetimes.co.uk}}</ref><ref>{{Cite web|url=https://www.q.bio/about |title=Our Mission and Values|website=www.q.bio|accessdate=16 May 2022}}</ref><ref>{{Cite web|url=https://stanfordmag.org/contents/body-count|title=Body Count|first=STANFORD|last=magazine|date=17 November 2021|website=stanfordmag.org|accessdate=16 May 2022}}</ref> January AI,<ref name="auto6">{{Cite news |last=Ravindran |first=Sandeep |date=14 March 2022 |title=Here Come the Artificial Intelligence Nutritionists |url=https://www.nytimes.com/2022/03/14/well/eat/ai-diet-personalized.html |accessdate=16 May 2022 |newspaper=The New York Times}}</ref> Filtricine, Mirvie, Protos, Protometrix<ref name="auto2">{{Cite web |date=2 April 2004 |title=Invitrogen Buys Protein Chip Maker Protometrix |url=https://www.genomeweb.com/archive/invitrogen-buys-protein-chip-maker-protometrix |accessdate=16 May 2022 |website=Genomeweb}}</ref> (now part of [[Thermo Fisher Scientific]]), and Affomix<ref name="auto4">{{Cite web |title=Michael Snyder |url=https://online.stanford.edu/instructors/michael-snyder |website=online.stanford.edu}}</ref> (now part of [[Illumina, Inc.|Illumina]]).<ref>{{cite web |title=Snyder Lab |url=https://med.stanford.edu/snyderlab/about.html |website=Stanford.edu |access-date=2 December 2021}}</ref>
Snyder has co-founded biotechnology companies, including Personalis,<ref name="auto9">{{Cite news |last=Eisenberg |first=Anne |date=2 June 2012 |title=A Geneticist's Research Turns Personal |url=https://www.nytimes.com/2012/06/03/business/geneticists-research-finds-his-own-diabetes.html |accessdate=16 May 2022 |newspaper=The New York Times}}</ref> SensOmics,<ref>{{Cite web|url=https://www.sensomics.com/|title=SensOmics, See the Unseen|website=SensOmics, See the Unseen}}</ref> Qbio,<ref name="auto">{{Cite news |last=Maxted |first=Anna |title=What's your ageing type? The four ways we grow old |url=https://www.thetimes.co.uk/article/whats-your-ageing-type-the-four-ways-we-grow-old-bhd2lrscp |accessdate=16 May 2022 |via=www.thetimes.co.uk}}</ref><ref>{{Cite web|url=https://www.q.bio/about |title=Our Mission and Values|website=www.q.bio|accessdate=16 May 2022}}</ref><ref>{{Cite web|url=https://stanfordmag.org/contents/body-count|title=Body Count|first=STANFORD|last=magazine|date=17 November 2021|website=stanfordmag.org|accessdate=16 May 2022}}</ref> January AI,<ref name="auto6">{{Cite news |last=Ravindran |first=Sandeep |date=14 March 2022 |title=Here Come the Artificial Intelligence Nutritionists |url=https://www.nytimes.com/2022/03/14/well/eat/ai-diet-personalized.html |accessdate=16 May 2022 |newspaper=The New York Times}}</ref> Filtricine, Mirvie, Protos, Protometrix<ref name="auto2">{{Cite web |date=2 April 2004 |title=Invitrogen Buys Protein Chip Maker Protometrix |url=https://www.genomeweb.com/archive/invitrogen-buys-protein-chip-maker-protometrix |accessdate=16 May 2022 |website=Genomeweb}}</ref> (now part of [[Thermo Fisher Scientific]]), and Affomix<ref name="auto4">{{Cite web |title=Michael Snyder |url=https://online.stanford.edu/instructors/michael-snyder |website=online.stanford.edu}}</ref> (now part of [[Illumina, Inc.|Illumina]]).<ref>{{cite web |title=Snyder Lab |url=https://med.stanford.edu/snyderlab/about.html |website=Stanford.edu |access-date=2 December 2021}}</ref>


== Research==
== Research==
Snyder has made contributions to [[medicine]], [[genomics]] and [[biotechnology]]. Snyder's laboratory has invented a number of novel systems-wide and genomics technologies. Snyder's laboratory at Yale initially focused on studying the genome of the yeast [[Saccharomyces cerevisiae]], a [[eukaryote]] model organism commonly used in genetics and molecular biology.<ref name="Bechard2021">{{cite news |last1=Bechard |first1=Deni Ellis |title=Body Count: How Michael Snyder's self-monitoring project could transform human health |url=https://stanfordmag.org/contents/body-count |access-date=2 December 2021 |work=Stanford Magazine |date=December 2021}}</ref> Later, the lab began to use the same techniques to look at the [[human genome]].<ref name="Bechard2021" />
Snyder has made contributions to [[medicine]], [[genomics]], and [[biotechnology]]. Snyder's laboratory has invented a number of novel systems-wide and genomics technologies. Snyder's laboratory initially focused on studying the genome of the yeast [[Saccharomyces cerevisiae]], a [[eukaryote]] model organism commonly used in genetics and molecular biology.<ref name="Bechard2021">{{cite news |last1=Bechard |first1=Deni Ellis |title=Body Count: How Michael Snyder's self-monitoring project could transform human health |url=https://stanfordmag.org/contents/body-count |access-date=2 December 2021 |work=Stanford Magazine |date=December 2021}}</ref> Later, the lab began to use the same techniques to look at the [[human genome]].<ref name="Bechard2021" />


In 2003, the [[ENCODE|Encyclopedia of DNA Elements]] (ENCODE) project was launched by the US [[National Human Genome Research Institute]] (NHGRI), with the goal of identifying all functional elements in the human genome. He has been a principal investigator in the ENCODE project since its inception in 2003 and his lab has contributed a large number of data sets.<ref name=Beadle />
In 2003, the [[ENCODE|Encyclopedia of DNA Elements]] (ENCODE) project was launched by the US [[National Human Genome Research Institute]] (NHGRI), with the goal of identifying all functional elements in the human genome. He has been a principal investigator in the ENCODE project since its inception in 2003 and the Snyder lab has contributed a large number of data sets.<ref name=Beadle />


== References ==
== References ==

Latest revision as of 13:32, 31 October 2024

Michael Paul Snyder
Born1955
Pottstown, Pennsylvania
NationalityAmerican
Alma materUniversity of Rochester California Institute of Technology
Occupation(s)Geneticist, Stanford W. Ascherman Professor
chair of genetics department, Stanford University
director of the Center for Genomics and Personalized Medicine
Known forRNA sequencing, ChIP-chip and CHIP-seq(11), genomics, pioneering multi-omic longitudinal health tracking, wearable technology, systems biology, systems medicine
Scientific career
FieldsGenetics, genomics, personalized medicine
InstitutionsYale University
Stanford University
Doctoral advisorDr. Norman Davidson
Other academic advisorsDr. Ronald Davis[1]

Michael Paul Snyder is an American genomicist, a Stanford School of Medicine professor, and chair of genetics and director of genomics and personalized medicine at Stanford University.[2][3]

Snyder's research has focused on "omics", the study of genomes, transcriptomes, proteomes, and other "-omes". His lab's work has specifically contributed to understanding the genomes and transcriptomes of first yeast and now humans. The Snyder lab pioneered the use of multi-omic longitudinal profiling to track health.[4][5]

Early life and education

[edit]

Snyder was born in 1955 and grew up outside of Pottstown, Pennsylvania.[6][7] His father, Kermit Snyder, was an accountant and his mother, Phyllis Snyder, was an elementary school teacher. Snyder attended Owen J. Roberts High school in Pottstown. He received a BA in chemistry and biology from the University of Rochester, NY and went on to receive a PhD in biology from the California Institute of Technology, where he trained in the laboratory of Norman Davidson.[8] [9] Snyder completed his postdoctoral training at Stanford University School of Medicine in the laboratory of Ronald W. Davis.[9]

Career and appointments

[edit]

Snyder started at Yale University in 1986 as an assistant professor in the department of biology.[8] He was granted tenure at Yale in 1994. In 1998, the department of biology split; Snyder served as chair of the new molecular, cellular and developmental biology (MCDB) department until 2004 as well as the director for the Center for Genomics and Proteomics.[1][9] His laboratory worked on chromosome segregation and cell polarity, which led to the discovery of a number of genes involved in these processes.[10][11]

In 2009, Snyder moved to Stanford University where he chaired the genetics department and directed the Center for Genomics and Personalized Medicine.[3][9] Snyder has served as principal investigator of the Center of Excellence in the Genome Sciences (CEGS) from 2001 to 2011 and is currently co-director of the CIRM Center for Stem Cell Genomics,[12] as well as director for the Center for Genome of Gene Regulation.[13]

Snyder was president of the US Human Proteome Organization from 2006 to 2008, elected to the American Academy of Arts and Sciences in 2015, and president of the international Human Proteome Organization from 2017 to 2018.[14] He currently leads the National Institutes of Health's Encyclopedia of DNA Elements (ENCODE)'s production center for mapping regulatory regions of the human genome.[15]

Snyder has co-founded biotechnology companies, including Personalis,[16] SensOmics,[17] Qbio,[18][19][20] January AI,[21] Filtricine, Mirvie, Protos, Protometrix[22] (now part of Thermo Fisher Scientific), and Affomix[23] (now part of Illumina).[24]

Research

[edit]

Snyder has made contributions to medicine, genomics, and biotechnology. Snyder's laboratory has invented a number of novel systems-wide and genomics technologies. Snyder's laboratory initially focused on studying the genome of the yeast Saccharomyces cerevisiae, a eukaryote model organism commonly used in genetics and molecular biology.[25] Later, the lab began to use the same techniques to look at the human genome.[25]

In 2003, the Encyclopedia of DNA Elements (ENCODE) project was launched by the US National Human Genome Research Institute (NHGRI), with the goal of identifying all functional elements in the human genome. He has been a principal investigator in the ENCODE project since its inception in 2003 and the Snyder lab has contributed a large number of data sets.[9]

References

[edit]
  1. ^ a b "Michael P. Snyder".
  2. ^ "Michael Snyder, Ph.D., STANFORD W. ASCHERMAN PROFESSOR OF GENETICS". Stanford profiles. 20 August 2015. Retrieved 19 April 2022.
  3. ^ a b "Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award!". 2 April 2019. Retrieved 16 May 2022.
  4. ^ Zhou W, Sailani MR, Contrepois K, Zhou Y, Ahadi S, Leopold SR, et al. (May 2019). "Longitudinal multi-omics of host-microbe dynamics in prediabetes". Nature. 569 (7758): 663–71. Bibcode:2019Natur.569..663Z. doi:10.1038/s41586-019-1236-x. PMC 6666404. PMID 31142858.
  5. ^ "How Multi-Omics Profiling Can Redefine Precision Health and Medicine - US". ThermoFisher Scientific.
  6. ^ "Michael P. Snyder". Retrieved 16 May 2022.
  7. ^ Marcus, Amy Dockser (14 May 2012). "What Happens When One Man's Genome Is Revealed". Wall Street Journal. Archived from the original on 2022-04-20. Retrieved 16 May 2022 – via www.wsj.com.
  8. ^ a b Sukel, Kayt. "Making It Personal: Geneticist Michael Snyder Puts a Face on Personalized Medicine". Pacific Standard. Retrieved 16 May 2022.
  9. ^ a b c d e Schmidt, Silke (9 April 2019). "Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award!". Genetics Society of America. Retrieved 8 February 2021.
  10. ^ Page BD, Snyder M (August 1992). "CIK1: a developmentally regulated spindle pole body-associated protein important for microtubule functions in Saccharomyces cerevisiae". Genes Dev. 6 (8): 1414–29. doi:10.1101/gad.6.8.1414. PMID 1644287. S2CID 24949358.
  11. ^ Roemer T, Madden K, Chang J, Snyder M (April 1996). "Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein". Genes Dev. 10 (7): 777–93. doi:10.1101/gad.10.7.777. PMID 8846915.
  12. ^ "The CIRM Center of Excellence in Stem Cell Genomics (CESCG)". California's Stem Cell Agency. 26 February 2015. Retrieved 16 May 2022.
  13. ^ "Snyder awarded $7.1 million from genome institute". News Center. Retrieved 16 May 2022.
  14. ^ "Michael Snyder". American Academy of Arts and Sciences. 13 September 2023.
  15. ^ "RePORT ⟩ RePORTER".
  16. ^ Eisenberg, Anne (2 June 2012). "A Geneticist's Research Turns Personal". The New York Times. Retrieved 16 May 2022.
  17. ^ "SensOmics, See the Unseen". SensOmics, See the Unseen.
  18. ^ Maxted, Anna. "What's your ageing type? The four ways we grow old". Retrieved 16 May 2022 – via www.thetimes.co.uk.
  19. ^ "Our Mission and Values". www.q.bio. Retrieved 16 May 2022. {{cite web}}: Check |url= value (help)
  20. ^ magazine, STANFORD (17 November 2021). "Body Count". stanfordmag.org. Retrieved 16 May 2022.
  21. ^ Ravindran, Sandeep (14 March 2022). "Here Come the Artificial Intelligence Nutritionists". The New York Times. Retrieved 16 May 2022.
  22. ^ "Invitrogen Buys Protein Chip Maker Protometrix". Genomeweb. 2 April 2004. Retrieved 16 May 2022.
  23. ^ "Michael Snyder". online.stanford.edu.
  24. ^ "Snyder Lab". Stanford.edu. Retrieved 2 December 2021.
  25. ^ a b Bechard, Deni Ellis (December 2021). "Body Count: How Michael Snyder's self-monitoring project could transform human health". Stanford Magazine. Retrieved 2 December 2021.
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