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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{PBB|geneid=7916}}
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'''Large proline-rich protein BAT2''' is a [[protein]] that in humans is encoded by the ''BAT2'' [[gene]].<ref name="pmid2156268">{{cite journal | author = Banerji J, Sands J, Strominger JL, Spies T | title = A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain | journal = Proc Natl Acad Sci U S A | volume = 87 | issue = 6 | pages = 2374–8 | year = 1990 | month = Apr | pmid = 2156268 | pmc = 53689 | doi =10.1073/pnas.87.6.2374 }}</ref><ref name="pmid8499947">{{cite journal | author = Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J, et al. | title = Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment | journal = Nat Genet | volume = 3 | issue = 2 | pages = 137–45 | year = 1993 | month = Jun | pmid = 8499947 | pmc = | doi = 10.1038/ng0293-137 }}</ref><ref name="entrez"/>
{{Infobox_gene}}
⚫
'''Large proline-rich protein BAT2''' is a [[protein]] that in humans is encoded by the ''BAT2'' [[gene]].<ref name="pmid2156268">{{cite journal | vauthors = Banerji J, Sands J, Strominger JL, Spies T | title = A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain | journal = Proc Natl Acad Sci U S A | volume = 87 | issue = 6 | pages = 2374–8 |date=Apr 1990 | pmid = 2156268 | pmc = 53689 | doi =10.1073/pnas.87.6.2374 | bibcode = 1990PNAS...87.2374B | doi-access = free }}</ref><ref name="pmid8499947">{{cite journal | vauthors = Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J | title = Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment | journal = Nat Genet | volume = 3 | issue = 2 | pages = 137–45 |date=Jun 1993 | pmid = 8499947 | doi = 10.1038/ng0293-137 | s2cid = 33041319 |display-authors=etal}}</ref><ref name="entrez"/>


== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->

{{PBB_Summary
⚫
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for [[TNF alpha]] and [[lymphotoxin|TNF beta]]. These genes are all within the human [[Major histocompatibility complex#Class III|major histocompatibility complex class III]] region. This gene has microsatellite repeats which are associated with the age-at-onset of [[Type_1_diabetes|insulin-dependent diabetes mellitus]] (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts encoding different isoforms described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: BAT2 HLA-B associated transcript 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7916}}</ref>
| section_title =
⚫
| summary_text = A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts encoding different isoforms described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: BAT2 HLA-B associated transcript 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7916| accessdate = }}</ref>
}}


==Interactions==
==Interactions==
BAT2 has been shown to [[Protein-protein interaction|interact]] with:
BAT2 has been shown to [[Protein-protein_interaction|interact]] with [[IFT88]],<ref name=pmid14667819>{{cite journal |last=Lehner |first=Ben |authorlink= |coauthors=Semple Jennifer I, Brown Stephanie E, Counsell Damian, Campbell R Duncan, Sanderson Christopher M |year=[[2004]]|month=Jan. |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue=1 |pages=153–67 |publisher= |location = United States| issn = 0888-7543| pmid = 14667819 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0888-7543(03)00235-0 }}</ref> [[C1QBP]],<ref name=pmid14667819/> [[EIF3S6]],<ref name=pmid14667819/> [[IMMT]],<ref name=pmid14667819/> [[UBAP2L]]<ref name=pmid14667819/> and [[Heterogeneous nuclear ribonucleoprotein A1]].<ref name=pmid14667819/>
* [[C1QBP]],<ref name = pmid14667819/>
* [[EIF3S6]],<ref name = pmid14667819/>
* [[Heterogeneous nuclear ribonucleoprotein A1|HNRNPA1]],<ref name = pmid14667819/>
* [[IFT88]],<ref name = pmid14667819>{{cite journal | date = Jan 2004 | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0}}</ref>
* [[IMMT]],<ref name = pmid14667819/> and
* [[UBAP2L]].<ref name = pmid14667819/>


==References==
==References==
{{reflist}}
{{reflist}}

==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | vauthors=Spies T, Bresnahan M, Strominger JL |title=Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8955–8 |year= 1989 |pmid= 2813433 |doi=10.1073/pnas.86.22.8955 | pmc=298409 |bibcode=1989PNAS...86.8955S |doi-access=free }}
{{PBB_Further_reading
*{{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
| citations =
*{{cite journal | author=Spies T, Bresnahan M, Strominger JL |title=Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8955–8 |year= 1989 |pmid= 2813433 |doi=10.1073/pnas.86.22.8955 | pmc=298409 }}
*{{cite journal | vauthors=Singal DP, Li J, Zhu Y |title=HLA class III region and susceptibility to rheumatoid arthritis |journal=Clin. Exp. Rheumatol. |volume=18 |issue= 4 |pages= 485–91 |year= 2000 |pmid= 10949724 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | vauthors=Hashimoto M, Nakamura N, Obayashi H |title=Genetic contribution of the BAT2 gene microsatellite polymorphism to the age-at-onset of insulin-dependent diabetes mellitus |journal=Hum. Genet. |volume=105 |issue= 3 |pages= 197–9 |year= 2000 |pmid= 10987645 |doi=10.1007/s004390051089 |doi-broken-date=2024-11-02 |display-authors=etal}}
*{{cite journal | author=Singal DP, Li J, Zhu Y |title=HLA class III region and susceptibility to rheumatoid arthritis. |journal=Clin. Exp. Rheumatol. |volume=18 |issue= 4 |pages= 485–91 |year= 2000 |pmid= 10949724 |doi= }}
*{{cite journal | vauthors=Matsuzaka Y, Makino S, Nakajima K |title=New polymorphic microsatellite markers in the human MHC class III region |journal=Tissue Antigens |volume=57 |issue= 5 |pages= 397–404 |year= 2002 |pmid= 11556964 |doi=10.1034/j.1399-0039.2001.057005397.x |display-authors=etal}}
*{{cite journal | author=Hashimoto M, Nakamura N, Obayashi H, ''et al.'' |title=Genetic contribution of the BAT2 gene microsatellite polymorphism to the age-at-onset of insulin-dependent diabetes mellitus. |journal=Hum. Genet. |volume=105 |issue= 3 |pages= 197–9 |year= 2000 |pmid= 10987645 |doi=10.1007/s004390051089 }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal | author=Matsuzaka Y, Makino S, Nakajima K, ''et al.'' |title=New polymorphic microsatellite markers in the human MHC class III region. |journal=Tissue Antigens |volume=57 |issue= 5 |pages= 397–404 |year= 2002 |pmid= 11556964 |doi=10.1034/j.1399-0039.2001.057005397.x }}
*{{cite journal | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |display-authors=etal|doi-access=free }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | vauthors=Xie T, Rowen L, Aguado B |title=Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621–36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 | pmc=403804 |display-authors=etal}}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | vauthors=Lehner B, Semple JI, Brown SE |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 |display-authors=etal}}
*{{cite journal | author=Xie T, Rowen L, Aguado B, ''et al.'' |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621–36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 | pmc=403804 }}
*{{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |display-authors=etal|doi-access=free }}
*{{cite journal | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 }}
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | vauthors=Schneiders A, Thiel S, Winkler J |title=Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide |journal=Vaccine |volume=23 |issue= 19 |pages= 2540–50 |year= 2005 |pmid= 15752841 |doi= 10.1016/j.vaccine.2004.08.003 |display-authors=etal}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | vauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal | author=Schneiders A, Thiel S, Winkler J, ''et al.'' |title=Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide. |journal=Vaccine |volume=23 |issue= 19 |pages= 2540–50 |year= 2005 |pmid= 15752841 |doi= 10.1016/j.vaccine.2004.08.003 }}
*{{cite journal | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |display-authors=etal}}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


==External links==
⚫
{{protein-stub}}
* {{UCSC gene info|PRRC2A}}


⚫
{{protein-stub}}
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Latest revision as of 04:15, 2 November 2024

PRRC2A
Identifiers
AliasesPRRC2A, BAT2, D6S51, D6S51E, G2, proline rich coiled-coil 2A
External IDsOMIM: 142580; MGI: 1915467; HomoloGene: 10567; GeneCards: PRRC2A; OMA:PRRC2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez

7916

53761

Ensembl

ENSMUSG00000024393

UniProt

P48634

Q7TSC1

RefSeq (mRNA)

NM_004638
NM_080686

NM_001199044
NM_020027

RefSeq (protein)

NP_004629
NP_542417

NP_001185973
NP_064411

Location (UCSC)Chr 6: 31.62 – 31.64 MbChr 17: 35.37 – 35.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Large proline-rich protein BAT2 is a protein that in humans is encoded by the BAT2 gene.[5][6][7]

Function

[edit]

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts encoding different isoforms described for this gene.[7]

Interactions

[edit]

BAT2 has been shown to interact with:

References

[edit]
  1. ^ a b c ENSG00000206427, ENSG00000231825, ENSG00000231370, ENSG00000226618, ENSG00000225164, ENSG00000225748 GRCh38: Ensembl release 89: ENSG00000204469, ENSG00000206427, ENSG00000231825, ENSG00000231370, ENSG00000226618, ENSG00000225164, ENSG00000225748 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024393 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Banerji J, Sands J, Strominger JL, Spies T (Apr 1990). "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain". Proc Natl Acad Sci U S A. 87 (6): 2374–8. Bibcode:1990PNAS...87.2374B. doi:10.1073/pnas.87.6.2374. PMC 53689. PMID 2156268.
  6. ^ Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J, et al. (Jun 1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment". Nat Genet. 3 (2): 137–45. doi:10.1038/ng0293-137. PMID 8499947. S2CID 33041319.
  7. ^ a b "Entrez Gene: BAT2 HLA-B associated transcript 2".
  8. ^ a b c d e f Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.

Further reading

[edit]
[edit]
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