KRT36: Difference between revisions

KRT36
Identifiers
Aliases	KRT36, HA6, KRTHA6, hHa6, keratin 36
External IDs	OMIM: 604540; MGI: 109364; HomoloGene: 88459; GeneCards: KRT36; OMA:KRT36 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,492,546 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,996,452 bp
RNA expression pattern
	Top expressed in
	testicle; ; body of tongue; ; superior surface of tongue; ; mucosa of esophagus; ; spleen; ; cervix; ; lymph node; ; skin of limb; ; skin of leg; ; granulocyte;
	Top expressed in
	lip; ; hair follicle; ; embryo; ; skin of external ear; ; skin of back; ; tongue; ; filiform papilla; ; skin of abdomen; ; mammary gland; ; oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; structural constituent of skin epidermis;
Cellular component	intermediate filament cytoskeleton; extracellular exosome; intermediate filament; cytosol;
Biological process	regulation of keratinocyte differentiation; keratinization; cornification; biological process;
	Sources:Amigo / QuickGO
Orthologs
	8689
	16673
	ENSG00000126337
	ENSMUSG00000020916
	O76013
	B1AQ75
	NM_003771
	NM_001174099; NM_008472
	NP_003762
	NP_001167570
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 09:34, 2 November 2024

Keratin, type I cuticular Ha6 is a protein that in humans is encoded by the KRT36 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126337 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020916 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT36 keratin 36".

Fuchs E, Weber K (1994). "Intermediate filaments: structure, dynamics, function, and disease". Annu. Rev. Biochem. 63: 345–82. doi:10.1146/annurev.bi.63.070194.002021. PMID 7979242.
Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126337 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020916 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9756910-5] Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[entrez-7] "Entrez Gene: KRT36 keratin 36".

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
+{{cs1 config|name-list-style=vanc}}
 {{Infobox_gene}}
-'''Keratin, type I cuticular Ha6''' is a [[protein]] that in humans is encoded by the ''KRT36'' [[gene]].<ref name="pmid9756910">{{cite journal | author = Rogers MA, Winter H, Wolf C, Heck M, Schweizer J | title = Characterization of a 190-kilobase pair domain of human type I hair keratin genes | journal = J Biol Chem | volume = 273 | issue = 41 | pages = 26683–91 |date=Nov 1998 | pmid = 9756910 | pmc =  | doi =10.1074/jbc.273.41.26683  }}</ref><ref name="pmid16831889">{{cite journal | author = Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW | title = New consensus nomenclature for mammalian keratins | journal = J Cell Biol | volume = 174 | issue = 2 | pages = 169–74 |date=Jul 2006 | pmid = 16831889 | pmc = 2064177 | doi = 10.1083/jcb.200603161 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KRT36 keratin 36| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8689| accessdate = }}</ref>
+'''Keratin, type I cuticular Ha6''' is a [[protein]] that in humans is encoded by the ''KRT36'' [[gene]].<ref name="pmid9756910">{{cite journal |vauthors=Rogers MA, Winter H, Wolf C, Heck M, Schweizer J | title = Characterization of a 190-kilobase pair domain of human type I hair keratin genes | journal = J Biol Chem | volume = 273 | issue = 41 | pages = 26683–91 |date=Nov 1998 | pmid = 9756910 | doi =10.1074/jbc.273.41.26683  | doi-access = free }}</ref><ref name="pmid16831889">{{cite journal |vauthors=Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW | title = New consensus nomenclature for mammalian keratins | journal = J Cell Biol | volume = 174 | issue = 2 | pages = 169–74 |date=Jul 2006 | pmid = 16831889 | pmc = 2064177 | doi = 10.1083/jcb.200603161 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KRT36 keratin 36| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8689}}</ref>
+The protein encoded by this gene is a member of the [[keratin]] gene family. This [[type I hair keratin]] is an acidic protein which [[heterodimerize]]s with [[type II keratin]]s to form hair and nails. The type I hair keratins are [[Gene cluster|clustered]] in a region of [[chromosome 17]]q21.2 and have the same direction of transcription.<ref name="entrez"/>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.<ref name="entrez">{{cite web | title = Entrez Gene: KRT36 keratin 36| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8689| accessdate = }}</ref>
-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  |vauthors=Fuchs E, Weber K |title=Intermediate filaments: structure, dynamics, function, and disease. |journal=Annu. Rev. Biochem. |volume=63 |pages= 345–82 |year= 1994 |pmid= 7979242 |doi= 10.1146/annurev.bi.63.070194.002021 }}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Fuchs E, Weber K |title=Intermediate filaments: structure, dynamics, function, and disease. |journal=Annu. Rev. Biochem. |volume=63 |issue=  |pages= 345–82 |year= 1994 |pmid= 7979242 |doi= 10.1146/annurev.bi.63.070194.002021 }}
 *{{cite journal   |vauthors=Yu J, Yu DW, Checkla DM, etal |title=Human hair keratins. |journal=J. Invest. Dermatol. |volume=101 |issue= 1 Suppl |pages= 56S–59S |year= 1993 |pmid= 7686952 |doi=10.1111/1523-1747.ep12362635  }}
 *{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 }}
-*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
+*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
-*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal   |vauthors=Langbein L, Rogers MA, Winter H, etal |title=The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19874–84 |year= 1999 |pmid= 10391933 |doi=10.1074/jbc.274.28.19874  }}
+*{{cite journal   |vauthors=Langbein L, Rogers MA, Winter H, etal |title=The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19874–84 |year= 1999 |pmid= 10391933 |doi=10.1074/jbc.274.28.19874  |doi-access=free }}
-}}
 {{refend}}
-{{gene-17-stub}}
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 {{Cytoskeletal proteins}}
+{{gene-17-stub}}