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{{Short description|Viral illness caused by the eastern equine encephalitis virus (EEEV)}}
{{Use dmy dates|date=August 2019}}
{{Use dmy dates|date=August 2019}}
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{{Infobox medical condition (new)
{{Infobox medical condition (new)
| name = Eastern equine encephalitis
| name = Eastern equine encephalitis
| synonyms =
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| symptoms = high fever, muscle pain, altered mental status, headache, meningeal irritation, photophobia, and seizures
| symptoms = high fever, muscle pain, altered mental status, headache, meningeal irritation, photophobia, and seizures
| complications =
| complications =
| onset =
| onset =
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⚫
| causes = ''Eastern equine encephalitis virus''
| types =
| risks = People over the age of 50 or younger than the age of 16 are at greatest risk of developing severe disease.{{medcn|date=October 2019}}
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| causes = ''Eastern equine encephalitis virus''
| diagnosis = Cerebrospinal fluid or brain tissue examination
| risks =
| differential =
| diagnosis = Brain Tissue Examination
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| prevention =
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| prognosis = ~33% fatality rate in severe cases<ref name="CDC"/>
| treatment =
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| deaths =
| prognosis = 35% risk of death
| frequency =
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}}
}}


'''Eastern equine encephalitis''' ('''EEE'''), commonly called '''Triple E''' or '''sleeping sickness''' (not to be confused with [[trypanosomiasis]]), is a [[zoonosis|zoonotic]] [[alphavirus]] and [[arbovirus]] present in North, Central, and South America, and the Caribbean. EEE was first recognized in [[Massachusetts]], United States, in 1831, when 75 [[horse]]s died mysteriously of [[viral encephalitis]].
'''Eastern equine encephalitis''' ('''EEE'''), commonly called '''Triple E''' or '''sleeping sickness''' (not to be confused with [[African trypanosomiasis]]), is a disease caused by a [[zoonosis|zoonotic]] mosquito-vectored ''[[Togavirus]]'' that is present in North, Central, and South America, and the Caribbean. EEE was first recognized in [[Massachusetts]], United States, in 1831, when 75 [[horse]]s died mysteriously of [[viral encephalitis]].
Epizootics in horses have continued to occur regularly in the United States. It can also be identified in donkeys and zebras. Due to the rarity of the disease, its occurrence can cause economic impact in relation to the loss of horses and poultry.<ref name="USDA">{{cite web|title=Eastern Equine Encephalomyelitis|url=https://www.aphis.usda.gov/publications/animal_health/content/printable_version/fs_eastern_equine_enceph.pdf|website=United States Department of Agriculture Animal and Plant Health Inspection Service|publisher=[[United States Department of Agriculture]] (USDA)|accessdate=1 May 2017}}</ref> EEE is found today in the eastern part of the United States and is often associated with coastal plains. It can most commonly be found in East Coast and Gulf Coast states.<ref name="CDC">{{cite web|title=Eastern Equine Encephalitis|url=https://www.cdc.gov/easternequineencephalitis/tech/symptoms.html|publisher=[[Centers for Disease Control and Prevention]] (CDC)|accessdate=30 April 2017}}</ref> In Florida, about one to two human cases are reported a year, although over 60 cases of equine encephalitis are reported. In years in which conditions are favorable for the disease, the number of equine cases is over 200.<ref name="Florida Health">{{cite web|title=Eastern Equine Encephalitis|url=http://www.floridahealth.gov/%5C/diseases-and-conditions/eastern-equine-encephalitis/index.html|website=Florida Health|publisher=Florida Health|accessdate=30 April 2017}}</ref> Diagnosing equine encephalitis is challenging because many of the symptoms are shared with other illnesses and patients can be asymptomatic. Confirmations may require a sample of cerebral spinal fluid or brain tissue, although CT scans and MRI scans are used to detect encephalitis. This could be an indication that the need to test for EEE is necessary. If a biopsy of the cerebral spinal fluid is taken, it is sent to a specialized laboratory for testing.<ref>{{cite journal |vauthors=Deresiewicz RL, Thaler SJ, Hsu L, Zamani AA |title=Clinical and neuroradiographic manifestations of eastern equine encephalitis |journal=N. Engl. J. Med. |volume=336 |issue=26 |pages=1867–74 |year=1997 |pmid=9197215 |doi=10.1056/NEJM199706263362604 }}</ref>
[[Epizootic]]s of EEE in horses have continued to occur regularly in the United States. It can also be identified in donkeys and zebras. Rarely, it can also infect humans. Due to the rarity of the disease, its occurrence can cause economic impact beyond the cost of horses and poultry.<ref name="USDA">{{cite web|title=Eastern Equine Encephalomyelitis|url=https://www.aphis.usda.gov/publications/animal_health/content/printable_version/fs_eastern_equine_enceph.pdf|website=United States Department of Agriculture Animal and Plant Health Inspection Service|publisher=[[United States Department of Agriculture]] (USDA)|access-date=1 May 2017|archive-date=3 February 2017|archive-url=https://web.archive.org/web/20170203120647/https://www.aphis.usda.gov/publications/animal_health/content/printable_version/fs_eastern_equine_enceph.pdf|url-status=dead}}</ref> EEE is found today in the eastern part of the United States and is often associated with coastal plains. It can most commonly be found in East Coast and Gulf Coast states.<ref name="CDC">{{cite web |title=About Eastern Equine Encephalitis | date=29 August 2024 |url=https://www.cdc.gov/eastern-equine-encephalitis/about/index.html?CDC_AAref_Val=https://www.cdc.gov/easternequineencephalitis/tech/symptoms.html |access-date=September 8, 2024 |publisher=[[Centers for Disease Control and Prevention]] (CDC)}}</ref> In Florida, about one to two human cases are reported a year, although over 60 cases of equine encephalitis are reported. In years in which conditions are favorable for the disease, the number of equine cases is over 200.<ref name="Florida Health">{{cite web|title=Eastern Equine Encephalitis|url=http://www.floridahealth.gov/%5C/diseases-and-conditions/eastern-equine-encephalitis/index.html|website=Florida Health|access-date=30 April 2017}}</ref> Diagnosing equine encephalitis is challenging because many of the symptoms are shared with other illnesses and patients can be asymptomatic. Confirmations may require a sample of cerebrospinal fluid or brain tissue, although CT scans and MRI scans are used to detect encephalitis. This could be an indication that the need to test for EEE is necessary. If a biopsy of the cerebrospinal fluid is taken, it is sent to a specialized laboratory for testing.<ref>{{cite journal |vauthors=Deresiewicz RL, Thaler SJ, Hsu L, Zamani AA |title=Clinical and neuroradiographic manifestations of eastern equine encephalitis |journal=N. Engl. J. Med. |volume=336 |issue=26 |pages=1867–74 |year=1997 |pmid=9197215 |doi=10.1056/NEJM199706263362604 |doi-access=free }}</ref>

⚫
EEEV is closely related to [[Venezuelan equine encephalitis virus]] and [[western equine encephalitis virus]].

==History==

At the start of the fall of 2019, a notable uptick in cases erupted in New England and Michigan, prompting some health departments to declare an outbreak.

As of October 2, 2019, four people have died in Michigan.<ref>{{Cite web|url=https://www.mlive.com/news/kalamazoo/2019/10/fourth-person-dies-from-mosquito-borne-illness-in-michigan.html|title=Fourth person dies from mosquito-borne illness in Michigan|last=Miller|first=Kayla|date=2019-10-02|website=mlive|language=en|access-date=2019-10-03}}</ref>


⚫
Eastern equine encephalitis virus (EEEV) is closely related to [[Venezuelan equine encephalitis virus]] and [[western equine encephalitis virus]].
On September 20, 2019, it was announced that two more people died in Connecticut and Massachusetts.<ref>{{Cite web|url=https://www.cbsnews.com/news/eastern-equine-encephalitis-at-least-6-dead-from-rare-disease-spread-by-mosquitoes-2019-09-20/|title=7 dead from rare disease spread by mosquitoes|last=September 20|first=Jonathan LaPook CBS News|last2=2019|website=www.cbsnews.com|language=en|access-date=2019-09-21|last3=Pm|first3=6:41}}</ref><ref>{{Cite web|url=https://www.wcvb.com/article/health-officials-2nd-person-dies-of-eee-in-states-10th-human-case-of-virus/29150873|title=Health officials: 2nd person dies of EEE in state's 10th human case of virus|date=2019-09-21|website=WCVB|language=en|access-date=2019-09-21}}</ref>


==Signs and symptoms==
==Signs and symptoms==
The virus can progress either systematically or encephalitically, depending on the person's age. Encephalitic disease involves swelling of the brain and can be asymptomatic, while the systemic illness occurs very abruptly. Those with the systemic illness usually recover within 1–2 weeks. While the encephalitis is more common among infants, in adults and children, it usually manifests after experiencing the systemic illness.<ref name="CDC"/> Symptoms include high [[fever]], [[muscle pain]], [[altered mental status]], [[headache]], [[meninges|meningeal]] irritation, [[photophobia]], and [[seizures]], which occur 3–10 days after the bite of an infected [[mosquito]]. Due to the virus's effect on the brain, patients who survive can be left with mental and physical impairments, such as personality disorders, paralysis, seizures, and intellectual impairment. <ref name="CDC"/>
The incubation period for Eastern equine encephalitis virus (EEEV) disease ranges from 4 to 10 days. The illness can progress either systematically or encephalitically, depending on the person's age. Encephalitic disease involves swelling of the brain and can be asymptomatic, while the systemic illness occurs very abruptly. Those with the systemic illness usually recover within 1–2 weeks. While the encephalitis is more common among infants, in adults and children, it usually manifests after experiencing the systemic illness.<ref name="CDC"/> Symptoms include high [[fever]], [[muscle pain]], [[altered mental status]], [[headache]], [[meninges|meningeal]] irritation, [[photophobia]], and [[seizures]], which occur 3–10 days after the bite of an infected [[mosquito]]. Due to the virus's effect on the brain, patients who survive can be left with mental and physical impairments, such as personality disorders, paralysis, seizures, and intellectual impairment.<ref name="CDC"/>


==Cause==
==Cause==
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| parent = Alphavirus
| parent = Alphavirus
| species = Eastern equine encephalitis virus
| species = Eastern equine encephalitis virus
| authority =
| synonyms =
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The causative agent, later identified as a [[togavirus]], was first isolated from infected horse brains in 1933. In 1938, the first confirmed human cases were identified when 30 children died of encephalitis in the Northeastern United States. These cases coincided with outbreaks in horses in the same regions. The fatality rate in humans is 33%, and currently no cure is known for human infections. This virus has four variations in the types in lineage. The most common to the human disease is group 1, which is considered to be endemic in North America and the Caribbean, while the other three lineages, groups IIA, IIB, and III, are typically found in Central and South America, causing equine illness.<ref name="CDC"/>
The causative agent, later identified as an [[alphavirus]], was first isolated from infected horse brains in 1933. In 1938, the first confirmed human cases were identified when 30 children died of encephalitis in the Northeastern United States. These cases coincided with outbreaks in horses in the same regions. The fatality rate in humans is 33%, and currently no cure is known for human infections. This virus has four variations in the types in lineage. The most common to the human disease is group 1, which is considered to be endemic in North America and the Caribbean, while the other three lineages, groups IIA, IIB, and III, are typically found in Central and South America, causing equine illness.<ref name="CDC"/>


These two clades may actually be distinct viruses.<ref name=Arrigo2010>{{cite journal |vauthors=Arrigo NC, Adams AP, Weaver SC |title=Evolutionary patterns of eastern equine encephalitis virus in North versus South America suggest ecological differences and taxonomic revision |journal=J. Virol. |volume=84 |issue=2 |pages=1014–25 |date=January 2010 |pmid=19889755 |pmc=2798374 |doi=10.1128/JVI.01586-09 }}</ref> The North American strains appear to be monotypic with a mutation rate of 2.7 × 10<sup>−4</sup> substitutions/site/year (s/s/y). It appears to have diverged from the other strains 922 to 4,856 years ago. The other strains are divided into two main clades and a third smaller one. The two main clades diverged between 577 and 2,927 years ago. The mutation rate in the genome has been estimated to be 1.2 × 10<sup>−4</sup> s/s/y.
These two clades may actually be distinct viruses.<ref name=Arrigo2010>{{cite journal |vauthors=Arrigo NC, Adams AP, Weaver SC |title=Evolutionary patterns of eastern equine encephalitis virus in North versus South America suggest ecological differences and taxonomic revision |journal=J. Virol. |volume=84 |issue=2 |pages=1014–25 |date=January 2010 |pmid=19889755 |pmc=2798374 |doi=10.1128/JVI.01586-09 }}</ref> The North American strains appear to be monotypic with a mutation rate of 2.7 × 10<sup>−4</sup> substitutions/site/year (s/s/y). It appears to have diverged from the other strains 922 to 4,856 years ago. The other strains are divided into two main clades and a third smaller one. The two main clades diverged between 577 and 2,927 years ago. The mutation rate in the genome has been estimated to be 1.2 × 10<sup>−4</sup> s/s/y.{{cn|date=April 2022}}


===Lifecycle===
===Lifecycle===
EEE is capable of infecting a wide range of animals, including [[mammal]]s, [[bird]]s, [[reptile]]s, and [[amphibian]]s. The virus is maintained in nature through a [[bird]]—[[mosquito]] cycle. Two mosquito species are primarily involved in this portion of the cycle; they are ''[[Culiseta melanura]]'' and ''{{ill|Culiseta morsitans|WD=Q13852319}}''. These mosquitoes feed on the blood of birds. The frequency of the virus found in nature increases throughout the summer as more birds and more mosquitoes become infected.
EEEV is capable of infecting a wide range of animals, including [[mammal]]s, [[bird]]s, [[reptile]]s, and [[amphibian]]s. The virus is maintained in nature through a [[bird]]—[[mosquito]] (enzootic) cycle. Two mosquito species are primarily involved in this portion of the cycle; they are ''[[Culiseta melanura]]''<ref>{{cite web|url=https://www.cdc.gov/eastern-equine-encephalitis/php/transmission/index.html|title=Transmission of Eastern Equine Encephalitis Virus|website=Eastern Equine Encephalitis Virus|date=20 May 2024 |publisher=U.S. Centers for Disease Control and Prevention|access-date=26 August 2024}}</ref> and ''{{ill|Culiseta morsitans|WD=Q13852319}}''.{{citation needed|date=August 2024}} These mosquitoes feed on the blood of birds. The frequency of the virus found in nature increases throughout the summer as more birds and more mosquitoes become infected.{{cn|date=April 2022}}


Transmission of EEEV to mammals (including humans) occurs via other mosquito species, which feed on the blood of both birds and mammals. These other mosquitoes are referred to as "bridge vectors" because they carry the virus from the avian hosts to other types of hosts, particularly mammals. The bridge vectors include ''[[Aedes vexans]]'', ''[[Coquillettidia perturbans]]'', ''[[Ochlerotatus canadensis]]'', and ''[[Ochlerotatus sollicitans]]''. ''[[Ochlerotatus canadensis]]'' also frequently bites turtles.
Transmission of EEEV to mammals (including humans) occurs via other mosquito species, which feed on the blood of both birds and mammals. These other mosquitoes are referred to as "bridge vectors" because they carry the virus from the avian hosts to other types of hosts, particularly mammals. The bridge vectors include ''[[Aedes taeniorhynchus]]''<ref>{{Cite journal|last=Kelser|first=R.A.|date=1937|title=Transmission of the Virus of Equine Encephalomy-elîtis by Aëdes taeniorhynchus|url=https://www.science.org/doi/10.1126/science.85.2198.178.a |journal=Science |volume=85-2198|issue=2198|pages=178|doi=10.1126/science.85.2198.178|pmid=17732932|bibcode=1937Sci....85..178K|s2cid=26044382 |url-access=subscription}}</ref>'', [[Aedes vexans]]'', ''[[Coquillettidia perturbans]]'', ''Ochlerotatus canadensis'', and ''[[Ochlerotatus sollicitans]]''. ''Ochlerotatus canadensis'' also frequently bites turtles.{{cn|date=September 2022}}


Humans, horses, and most other infected mammals do not circulate enough viruses in their blood to infect additional mosquitoes. Some cases of EEEV have been contracted through laboratory exposures or from exposure of the eyes, lungs, or skin wounds to brain or spinal cord matter from infected animals.
Humans, horses, and most other infected mammals do not circulate enough viruses in their blood to infect additional mosquitoes. Some cases of EEE have been contracted through laboratory exposures or from exposure of the eyes, lungs, or skin wounds to brain or spinal cord matter from infected animals.{{cn|date=April 2022}}


==Prevention==
==Prevention==
The disease can be prevented in horses with the use of [[vaccination]]s, which are usually given with vaccinations for other diseases, most commonly [[western equine encephalitis virus]], [[Venezuelan equine encephalitis virus]], and [[tetanus]]. Most vaccinations for EEE consist of the killed virus. For humans, no vaccine for EEE is available; prevention involves reducing the risk of exposure. Using insect repellent, wearing protective clothing, and reducing the amount of standing water is the best means for prevention.<ref name="CDC"/>
The disease can be prevented in horses with the use of [[vaccination]]s, which are usually given with vaccinations for other diseases, most commonly [[western equine encephalitis virus]], [[Venezuelan equine encephalitis virus]], and [[tetanus]]. Most vaccinations for EEE consist of the killed virus. For humans, no vaccine for EEE is available; prevention involves reducing the risk of exposure. Using insect repellent, wearing protective clothing, and reducing the amount of standing water is the best means for prevention.<ref name="CDC"/>


==Treatment and prognosis==
==Treatment==
[[File:Eastern equine encephalitis head scans.jpg|thumbnail|Magnetic resonance images (MRIs) and computed tomography (CT) neuroradiographs showing lesions in brains of three children with eastern equine encephalitis: A) Results of noncontrast CT scan of the brain of patient 12 on hospital day 2; the neuroradiograph shows subtle hypoattenuation of the left caudate head (arrow) and diencephalic region. B) Axial fluid attenuated inversion recovery image from brain MRI scan of patient 14 on hospital day 2; the image shows abnormal T2 hyperintense regions of the bimesial temporal regions (thick arrows) with accompanying abnormal T2 hyperintense regions of the dorsal pontomesencephalic regions (thin arrows). C, D) FLAIR images from brain MRI scan of patient 15 on hospital day 3. C) Abnormal T2 hyperintense caudate and thalamic nuclei, most prominent on the right (arrow). D) Abnormal T2 hyperintense regions are most prominent in the right parietotemporal gray matter (arrow) and subcortical white matter but are also seen scattered throughout.]]
[[File:Eastern equine encephalitis head scans.jpg|thumbnail|Magnetic resonance images (MRIs) and computed tomography (CT) neuroradiographs showing lesions in brains of three children with eastern equine encephalitis: A) Results of noncontrast CT scan of the brain of patient 12 on hospital day 2; the neuroradiograph shows subtle hypoattenuation of the left caudate head (arrow) and diencephalic region. B) Axial fluid attenuated inversion recovery image from brain MRI scan of patient 14 on hospital day 2; the image shows abnormal T2 hyperintense regions of the bimesial temporal regions (thick arrows) with accompanying abnormal T2 hyperintense regions of the dorsal pontomesencephalic regions (thin arrows). C, D) FLAIR images from brain MRI scan of patient 15 on hospital day 3. C) Abnormal T2 hyperintense caudate and thalamic nuclei, most prominent on the right (arrow). D) Abnormal T2 hyperintense regions are most prominent in the right parietotemporal gray matter (arrow) and subcortical white matter but are also seen scattered throughout.]]
No cure for EEE has been found. Treatment consists of [[corticosteroids]], [[anticonvulsants]], and supportive measures (treating symptoms)<ref name=cdceee >{{cite web |url=https://www.cdc.gov/EasternEquineEncephalitis/tech/symptoms.html |title=Eastern Equine Encephalitis |date=16 August 2010 |publisher=[[Centers for Disease Control and Prevention]] (CDC) |accessdate=7 August 2012}}</ref> such as intravenous fluids, [[tracheal intubation]], and [[antipyretics]].{{Citation needed|date=December 2009}} About 4% of humans known to be infected develop symptoms, with a total of about six cases per year in the US.<ref name=cdceee /> A third of these cases die, and many survivors suffer permanent brain damage.<ref name=cdc-fact >{{cite web |url=https://www.cdc.gov/EasternEquineEncephalitis/tech/symptoms.html |title=Eastern Equine Encephalitis Fact Sheet |date=16 August 2010 |publisher=[[Centers for Disease Control and Prevention]] (CDC) |accessdate=30 August 2015}}</ref>
No cure for EEE has been found. Treatment consists of [[corticosteroids]], [[anticonvulsants]], and supportive measures (treating symptoms)<ref name=cdceee >{{cite web |url=https://www.cdc.gov/EasternEquineEncephalitis/tech/symptoms.html |title=Eastern Equine Encephalitis |date=16 August 2010 |publisher=[[Centers for Disease Control and Prevention]] (CDC) |access-date=7 August 2012}}</ref> such as intravenous fluids, [[tracheal intubation]], and [[antipyretics]].{{Citation needed|date=December 2009}} About 4% of humans known to be infected develop symptoms, with a total of about six cases per year in the US.<ref name=cdceee /> A third of these cases die, and many survivors suffer permanent brain damage.<ref name=cdc-fact >{{cite web |url=https://www.cdc.gov/EasternEquineEncephalitis/tech/symptoms.html |title=Eastern Equine Encephalitis Fact Sheet |date=16 August 2010 |publisher=[[Centers for Disease Control and Prevention]] (CDC) |access-date=30 August 2015}}</ref>


==Epidemiology==
==Epidemiology==
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===United States===
===United States===
[[Image:Eastern equine encephalitis incidence map.gif|thumb|left|A disease-incidence map for human cases of EEE, 1964–2010]]
[[Image:Eastern equine encephalitis incidence map.gif|thumb|left|A disease-incidence map for human cases of EEE, 1964–2010]]
Several states in the Northeast U.S. have had increased virus activity since 2004. Between 2004 and 2006, at least 10 human cases of EEE were reported in Massachusetts. In 2006, about {{convert|500000|acre|km2}} in southeastern Massachusetts were treated with mosquito adulticides to reduce the risk of humans contracting EEE. Several human cases were reported in New Hampshire, as well.<ref>{{cite news|title=Mosquito-borne virus infects 2d in Mass|author=Zheng, Y.|url=http://www.boston.com/news/local/massachusetts/articles/2006/08/18/mosquito_borne_virus_infects_2d_in_mass/|newspaper=[[The Boston Globe]]|date=16 August 2008}}</ref><ref>{{cite news|title=Middleborough boy with EEE dies|author1=the Boston Globe City |author2=Region Desk |url=http://www.boston.com/news/globe/city_region/breaking_news/2006/08/middleborough_b.html|newspaper=[[The Boston Globe]]|date=31 August 2006}}{{dead link|date=August 2019}}</ref>
Several states in the Northeast U.S. have had increased virus activity since 2004. Between 2004 and 2006, at least ten human cases of EEE were reported in Massachusetts. In 2006, about {{convert|500000|acre|km2}} in southeastern Massachusetts were treated with mosquito adulticides to reduce the risk of humans contracting EEE. Several human cases were reported in New Hampshire, as well.<ref>{{cite news|title=Mosquito-borne virus infects 2d in Mass|first=Yuxing |last=Zheng|url=http://www.boston.com/news/local/massachusetts/articles/2006/08/18/mosquito_borne_virus_infects_2d_in_mass/|newspaper=[[The Boston Globe]]|date=16 August 2008}}</ref><ref>{{cite news|title=Middleborough boy with EEE dies|first=Yuxing|last=Zheng|url=http://www.boston.com/news/globe/city_region/breaking_news/2006/08/middleborough_b.html|newspaper=[[The Boston Globe]]|date=31 August 2006|access-date=31 August 2006|archive-url=https://web.archive.org/web/20060902040927/http://www.boston.com/news/globe/city_region/breaking_news/2006/08/middleborough_b.html|archive-date=2 September 2006|url-status=dead}}</ref>


On 19 July 2012, the virus was identified in a mosquito of the species ''Coquillettidia perturbans'' in [[Nickerson State Park]] on [[Cape Cod|Cape Cod, Massachusetts]]. On 28 July 2012, the virus was found in mosquitos in [[Pittsfield, Massachusetts]].<ref>{{cite news|title=Rare, deadly virus found in mosquitoes in Pittsfield|author=Kane, T.|url=http://www.news10.com/story/19135352/rare-deadly-virus-found-in-mosquitoes-in-pittsfield|newspaper=News10|date=27 July 2012}}</ref>
In July 2012, the virus was identified in a mosquito of the species ''Coquillettidia perturbans'' in [[Nickerson State Park]] on [[Cape Cod|Cape Cod, Massachusetts]]. On 28 July 2012, the virus was found in mosquitos in [[Pittsfield, Massachusetts]].<ref>{{cite news|title=Rare, deadly virus found in mosquitoes in Pittsfield|last=Kane |first=Taryn|url=http://www.news10.com/story/19135352/rare-deadly-virus-found-in-mosquitoes-in-pittsfield|newspaper=News10|date=27 July 2012 | archive-url=https://web.archive.org/web/20120730234312/https://www.news10.com/story/19135352/rare-deadly-virus-found-in-mosquitoes-in-pittsfield |archive-date=2012-07-30 | url-status=dead}}</ref>


{{As of|September 2019}}, there is a resurgence of human cases.<ref>{{cite web | title=Two more EEE human cases reported, raising the state's count to seven | website=[[The Boston Globe]] | first1=Travis | last1=Andersen | first2=Danny | last2=McDonald | date=September 6, 2019 | url=https://www.bostonglobe.com/metro/2019/09/06/two-more-human-cases-eee-confirmed-state-health-officials-people-have-contracted-virus/uFSuUSiSixfN7OXSLtHwbP/story.html | access-date=September 6, 2019}}</ref><ref>{{cite news | title=Why Is EEE Highest In Southeastern Massachusetts? | publisher=CBS Boston | date=22 August 2019 | url=https://boston.cbslocal.com/2019/08/22/eee-eastern-equine-encephalitis-southeastern-massachusetts-mosquito-testing-spraying/ | access-date=22 August 2019}}</ref><ref>{{cite news | title=Second Human Case Of EEE Confirmed In Mass.; 10 More Towns Now At Critical Risk | publisher=CBS Boston | date=16 August 2019 | url=https://boston.cbslocal.com/2019/08/16/eee-human-case-massachusetts-towns-critical-risk/ | access-date=22 August 2019}}</ref><ref>{{cite news | title=It's code red for EEE in nine communities south of Boston | work=[[The Boston Globe]] | date=13 August 2019 | url=https://www.bostonglobe.com/metro/globelocal/2019/08/13/code-red-for-eee-nine-communities-south-boston/d5FZypxHPgAt3KST0C7cAL/story.html | access-date=22 August 2019}}</ref><ref>{{cite news | url=https://www.wcvb.com/article/massachusetts-man-infected-with-eee-now-in-coma-family-says/28684731 | title=Massachusetts man infected with EEE now in coma, family says | date=13 August 2019 | first=Sera |last=Congi | publisher=[[WCVB-TV]] | access-date=22 August 2019}}</ref> The virus was also found in goats<ref>{{cite web | last=Anderson | first=Derek J. | title=A 2nd Person In Mass. Is Diagnosed With Mosquito-Linked EEE Disease | publisher=[[WBUR-FM]] | date=17 August 2019 | url=https://www.wbur.org/commonhealth/2019/08/17/mosquito-worcester-county-dph-virus-critical-risk | access-date=22 August 2019}}</ref> and in horses.<ref>{{cite news | title=18 Louisiana Horses Confirmed Positive for EEE or WNV | website=[[The House (magazine)|The Horse]] | date=21 August 2019 | url=https://thehorse.com/177785/18-louisiana-horses-confirmed-positive-for-eee-or-wnv/ | access-date=22 August 2019}}</ref>
{{As of|September 2019}}, a notable uptick in cases erupted in New England and Michigan, prompting some health departments to declare an outbreak.<ref>{{cite news | title=Two more EEE human cases reported, raising the state's count to seven | website=[[The Boston Globe]] | first1=Travis | last1=Andersen | first2=Danny | last2=McDonald | date=6 September 2019 | url=https://www.bostonglobe.com/metro/2019/09/06/two-more-human-cases-eee-confirmed-state-health-officials-people-have-contracted-virus/uFSuUSiSixfN7OXSLtHwbP/story.html | access-date=6 September 2019 | archive-url=https://web.archive.org/web/20191114044444/https://www.bostonglobe.com/metro/2019/09/06/two-more-human-cases-eee-confirmed-state-health-officials-people-have-contracted-virus/uFSuUSiSixfN7OXSLtHwbP/story.html | archive-date=14 November 2019 | url-status=live }}</ref><ref>{{cite news | title=Why Is EEE Highest In Southeastern Massachusetts? | publisher=CBS Boston | date=22 August 2019 | url=https://boston.cbslocal.com/2019/08/22/eee-eastern-equine-encephalitis-southeastern-massachusetts-mosquito-testing-spraying/ | access-date=22 August 2019}}</ref><ref>{{cite news | title=Second Human Case Of EEE Confirmed In Mass.; 10 More Towns Now At Critical Risk | publisher=CBS Boston | date=16 August 2019 | url=https://boston.cbslocal.com/2019/08/16/eee-human-case-massachusetts-towns-critical-risk/ | access-date=22 August 2019}}</ref><ref>{{cite news | title=It's code red for EEE in nine communities south of Boston | first=Johanna | last=Seltz | work=[[The Boston Globe]] | date=13 August 2019 | url=https://www.bostonglobe.com/metro/globelocal/2019/08/13/code-red-for-eee-nine-communities-south-boston/d5FZypxHPgAt3KST0C7cAL/story.html | access-date=22 August 2019}}</ref><ref>{{cite news | url=https://www.wcvb.com/article/massachusetts-man-infected-with-eee-now-in-coma-family-says/28684731 | title=Massachusetts man infected with EEE now in coma, family says | date=13 August 2019 | first=Sera |last=Congi | publisher=[[WCVB-TV]] | access-date=22 August 2019}}</ref><ref>{{cite news|url=https://www.cbsnews.com/news/eastern-equine-encephalitis-at-least-6-dead-from-rare-disease-spread-by-mosquitoes-2019-09-20/|title=7 dead from rare disease spread by mosquitoes|date=21 September 2019|first=Jonathan |last=LaPook |website=CBS News|access-date=2019-09-21}}</ref><ref name="CNN">{{cite news | last=Almasy | first=Steve | title=Connecticut Eastern equine encephalitis death is 10th nationwide | website=CNN | date=2 October 2019 | url=https://www.cnn.com/2019/10/01/health/eee-eastern-equine-encephalitis-connecticut-death/index.html | archive-url=https://web.archive.org/web/20191114040136/https://www.cnn.com/2019/10/01/health/eee-eastern-equine-encephalitis-connecticut-death/index.html | archive-date=14 November 2019 | url-status=live | access-date=14 November 2019 }}</ref> {{As of|2019|10|31}}, five people died in Michigan,<ref>{{cite news|url=https://www.mlive.com/news/kalamazoo/2019/10/fourth-person-dies-from-mosquito-borne-illness-in-michigan.html|title=Fourth person dies from mosquito-borne illness in Michigan|last=Miller|first=Kayla|date=2019-10-02|website=mlive|access-date=2019-10-03}}</ref><ref name="UpNorthLive" /> three people died in Connecticut,<ref>{{cite news | last=Cuda | first=Amanda | title=Third person in state dies from EEE | website=Connecticut Post | date=1 September 2019 | url=https://www.ctpost.com/local/article/Third-person-in-state-dies-from-EEE-14483983.php | access-date=16 October 2019 | archive-date=17 October 2019 | archive-url=https://web.archive.org/web/20191017021222/https://www.ctpost.com/local/article/Third-person-in-state-dies-from-EEE-14483983.php | url-status=dead }}</ref> one person died in Rhode Island,<ref name="CNN" /> one person died in Alabama,<ref>{{cite news | last=Gore | first=Leada | title=Mosquito-borne virus kills 1 in Alabama: What to know about EEE | website=al | date=28 October 2019 | url=https://www.al.com/news/2019/10/mosquito-borne-virus-kills-1-in-alabama-what-to-know-about-eee.html | archive-url=https://web.archive.org/web/20191114035109/https://www.al.com/news/2019/10/mosquito-borne-virus-kills-1-in-alabama-what-to-know-about-eee.html | archive-date=14 November 2019 | url-status=live | access-date=14 November 2019 }}</ref> one person died in Indiana,<ref>{{cite news | title=1st Eastern Equine Encephalitis Human Death Reported in Indiana | website=News18 | date=20 October 2019 | url=https://www.news18.com/news/world/1st-eastern-equine-encephalitis-human-death-reported-in-indiana-2352805.html | archive-url=https://web.archive.org/web/20191114042845/https://www.news18.com/news/world/1st-eastern-equine-encephalitis-human-death-reported-in-indiana-2352805.html | archive-date=14 November 2019 | url-status=live | access-date=14 November 2019}}</ref> and three people died in Massachusetts.<ref>{{cite news | last=Klein | first=Asher | title=Mass. Health Officials Say 12th Person Has EEE, 1 Fewer Death | website=NBC10 Boston | date=26 September 2019 | url=https://www.nbcboston.com/news/local/Mass-Health-Officials-12th-Person-EEE-1-Fewer-Death-561462071.html | archive-url=https://web.archive.org/web/20191114041131/https://www.nbcboston.com/news/local/Mass-Health-Officials-12th-Person-EEE-1-Fewer-Death-561462071.html | archive-date=14 November 2019 | url-status=live | access-date=14 November 2019 }}</ref><ref>{{cite news | last1=Pescaro | first1=Mike | last2=Klein | first2=Asher | title=UPDATE: Mass. Health Officials Give New Info on EEE-Related Deaths | website=NBC10 Boston | date=25 September 2019 | url=https://www.nbcboston.com/news/local/4th-Death-From-EEE-This-Year-in-Mass-Confirmed-by-Health-Officials-561356151.html | archive-url=https://web.archive.org/web/20191114041108/https://www.nbcboston.com/news/local/4th-Death-From-EEE-This-Year-in-Mass-Confirmed-by-Health-Officials-561356151.html | archive-date=14 November 2019 | url-status=live | access-date=14 November 2019 }}</ref><ref>{{cite news | title=Mass. retracts number of EEE deaths; confirms 12th human case of virus | website=[[The Boston Globe]] | date=26 September 2019 | url=https://www.bostonglobe.com/metro/2019/09/26/mass-retracts-number-eee-deaths-confirms-human-case-virus/OLoLvr0FiKfhXMvG5AQH8J/story.html | archive-url=https://web.archive.org/web/20191114041826/https://www.bostonglobe.com/metro/2019/09/26/mass-retracts-number-eee-deaths-confirms-human-case-virus/OLoLvr0FiKfhXMvG5AQH8J/story.html | archive-date=14 November 2019 | url-status=live | access-date=14 November 2019 }}</ref> The virus was also found in goats,<ref>{{cite news | last=Anderson | first=Derek J. | title=A 2nd Person In Mass. Is Diagnosed With Mosquito-Linked EEE Disease | publisher=[[WBUR-FM]] | date=17 August 2019 | url=https://www.wbur.org/commonhealth/2019/08/17/mosquito-worcester-county-dph-virus-critical-risk | access-date=22 August 2019}}</ref> in turkeys,<ref name="Tribune-Review">{{cite news | title=Pennsylvania Game Commission advises hunters to take precautions against EEE virus | website=[[Pittsburgh Tribune-Review]] | date=22 October 2019 | url=https://triblive.com/news/pennsylvania/pennsylvania-game-commission-advises-hunters-to-take-precautions-against-eee-virus/ | archive-url=https://web.archive.org/web/20191114042331/https://triblive.com/news/pennsylvania/pennsylvania-game-commission-advises-hunters-to-take-precautions-against-eee-virus/ | archive-date=14 November 2019 | url-status=dead | access-date=14 November 2019}}</ref> in deer,<ref name="Tribune-Review" /> and in horses.<ref>{{cite news | title=18 Louisiana Horses Confirmed Positive for EEE or WNV | website=[[The House (magazine)|The Horse]] | date=21 August 2019 | url=https://thehorse.com/177785/18-louisiana-horses-confirmed-positive-for-eee-or-wnv/ | access-date=22 August 2019}}</ref><ref name="UpNorthLive">{{cite news | last=Mahieu | first=Devon | title=Fifth person in Michigan dies from Eastern Equine Encephalitis | website=UpNorthLive | date=15 October 2019 | url=https://upnorthlive.com/news/local/fifth-person-in-michigan-dies-from-eastern-equine-encephalitis | archive-url=https://web.archive.org/web/20191114034332/https://upnorthlive.com/news/local/fifth-person-in-michigan-dies-from-eastern-equine-encephalitis | archive-date=14 November 2019 | url-status=live | access-date=14 November 2019 }}</ref><ref>{{cite news | last=Mulder | first=James | title=Eastern equine encephalitis kills another horse in Oswego County | website=syracuse | date=1 October 2019 | url=https://www.syracuse.com/health/2019/11/eastern-equine-encephalitis-kills-another-horse-in-oswego-county.html | archive-url=https://web.archive.org/web/20191114043603/https://www.syracuse.com/health/2019/11/eastern-equine-encephalitis-kills-another-horse-in-oswego-county.html | archive-date=14 November 2019 | url-status=live | access-date=14 November 2019 }}</ref><ref name="CNN" /><ref name="Tribune-Review" />

As of September 2020, there were five confirmed human cases between Massachusetts and Wisconsin.<ref>{{Cite web|title=Michiganders urged to stay indoors as officials race to stop the spread of a dangerous mosquito-borne disease|url=https://www.cnn.com/2020/09/17/health/michigan-eee-case-suspected-trnd/index.html|access-date=2020-10-26|website=CNN|date=17 September 2020 }}</ref> As of October 9, 2020, one person died in Michigan,<ref>{{Cite web|date=2020-10-02|title=West Michigan resident with EEE dies|url=https://www.mlive.com/news/grand-rapids/2020/10/west-michigan-resident-with-eee-dies.html|access-date=2020-10-26|website=mlive|language=en}}</ref> and one person died in Wisconsin.<ref>{{Cite news|title=Wisconsin woman dies of rare disease carried by mosquitoes|work=Milwaukee Journal Sentinel|url=https://www.jsonline.com/story/news/local/milwaukee/2020/09/04/eee-wisconsin-first-death-reported-mosquito-borne-virus/5724125002/|access-date=2020-10-25}}</ref>

In 2024, a man in New Hampshire died due to the virus.<ref>{{Cite web |date=2024-08-28 |title=New Hampshire resident dies from EEE, a rare mosquito-borne virus |url=https://www.nbcnews.com/health/health-news/new-hampshire-resident-dies-eee-rare-mosquito-borne-virus-rcna168433 |access-date=2024-09-02 |website=NBC News |language=en}}</ref> In Plymouth Massachusetts, the town closed parks in the evenings due to new cases being found in August 2024.<ref>https://www.plymouth-ma.gov/DocumentCenter/View/6479/Plymouth-Park-and-Field-Closures---EEE-Press-Release?bidId=</ref> Spraying for mosquitos is being used to reduce the risk of EEE.<ref>{{cite web | title=Mosquito control and spraying | website=Mass.gov | date=31 August 2024 | url=https://www.mass.gov/info-details/mosquito-control-and-spraying | access-date=1 September 2024}}</ref><ref>{{cite web | title=EEE (Eastern Equine Encephalitis) | website=Mass.gov | url=https://www.mass.gov/info-details/eee-eastern-equine-encephalitis | access-date=1 September 2024}}</ref><ref>{{cite web | title=State officials announce plans to spray for mosquitoes in sections of Worcester and Plymouth counties due to EEE | website=Mass.gov | url=https://www.mass.gov/news/state-officials-announce-plans-to-spray-for-mosquitoes-in-sections-of-worcester-and-plymouth-counties-due-to-eee | access-date=1 September 2024}}</ref><ref>{{cite web | title=Massachusetts arbovirus update | website=Mass.gov | url=https://www.mass.gov/info-details/massachusetts-arbovirus-update | access-date=1 September 2024}}</ref>


===Europe===
===Europe===
In October 2007, a citizen of [[Livingston, West Lothian]], Scotland became the first European victim of this disease. The man had visited New Hampshire during the summer of 2007, on a fishing vacation, and was diagnosed as having EEE on 13 September 2007. He fell ill with the disease on 31 August 2007, just one day after flying home.<ref>{{cite news|title=Man in coma after mosquito bite|url=http://news.bbc.co.uk/1/hi/scotland/edinburgh_and_east/7033203.stm|publisher=[[BBC News Online]]|date=8 October 2007}}</ref>
In October 2007, a citizen of [[Livingston, West Lothian]], Scotland became the first European victim of this disease. The man had visited New Hampshire during the summer of 2007, on a fishing vacation, and was diagnosed as having EEE on 13 September 2007. He fell ill with the disease on 31 August 2007, just one day after flying home, and later fell into a coma.<ref>{{cite news|title=Man in coma after mosquito bite|url=http://news.bbc.co.uk/1/hi/scotland/edinburgh_and_east/7033203.stm|publisher=[[BBC News Online]]|date=8 October 2007}}</ref> He later awoke from the coma with severe brain injuries.<ref>{{Cite news|url=https://www.scotsman.com/news-2-15012/family-thrilled-by-recovery-of-killer-virus-victim-1-1428527|title=Family thrilled by recovery of killer virus victim|date=22 December 2007|work=The Scotsman|access-date=4 February 2020}}</ref>


==Biological weapon==
==Biological weapon==
EEEV was one of more than a dozen agents that the United States researched as potential biological weapons before the nation suspended its biological-weapons program with the ratification of the [[Biological Weapons Convention]].<ref name=jmcenter>{{cite web|title=Chemical and Biological Weapons: Possession and Programs Past and Present |date=9 April 2002 |work=James Martin Center for Nonproliferation Studies |publisher=[[Middlebury College]] |url=http://cns.miis.edu/research/cbw/possess.htm |archive-url=http://webarchive.loc.gov/all/20011002153149/http://www.cns.miis.edu/research/cbw/possess.htm |url-status=dead |archive-date=2 October 2001 |accessdate=14 November 2008 }}</ref>
EEEV was one of more than a dozen agents that the United States researched as potential biological weapons before the nation suspended its [[United States biological weapons program|biological-weapons program]] in 1969, a few years before signing (1972) and then ratifying (1975) the [[Biological Weapons Convention]].<ref name=jmcenter>{{cite web|title=Chemical and Biological Weapons: Possession and Programs Past and Present |date=March 2008|publisher=James Martin Center for Nonproliferation Studies, [[Middlebury College]]|url=http://www.nonproliferation.org/wp-content/uploads/2016/03/2008-Chemical-and-Biological-Weapons_-Possession-and-Programs-Past-and-Present.pdf}}</ref>


==Other animals==
==Other animals==
{{unreferenced section|date=August 2019}}
{{refimprove section|date=November 2022}}
⚫
After inoculation by the vector, the virus travels via lymphatics to lymph nodes, and replicates in macrophages and neutrophils, resulting in lymphopenia, leukopenia, and fever. Subsequent replication occurs in other organs, leading to viremia. Symptoms in horses occur 1–3 weeks after infection, and begin with a fever that may reach as high as 106&nbsp;°F (41&nbsp;°C). The fever usually lasts for 24–48 hours.{{mcn|date=August 2019}}


From its natural reservoir in birds, EEEV is known to infect reptiles and amphibians as well as both humans and other mammals, including horses.<ref>{{cite web|url=https://ceh.vetmed.ucdavis.edu/health-topics/eastern-equine-encephalitis-eee |title=Eastern Equine Encephalitis (EEE) |first=Amy |last=Young |date=August 28, 2020 |work=ceh.vetmed.ucdavis.edu |access-date=November 5, 2022}}</ref>
⚫
Nervous signs appear during the fever that include sensitivity to sound, periods of excitement, and restlessness. Brain lesions appear, causing drowsiness, drooping ears, circling, aimless wandering, [[head pressing]], inability to swallow, and abnormal gait. Paralysis follows, causing the horse to have difficulty raising its head. The horse usually suffers complete paralysis and death 2–4 days after symptoms appear. Mortality rates among horses with the eastern strain range from 70 to 90%.{{mcn|date=August 2019}}


===Horses===
⚫
After inoculation by the vector, the virus travels via lymphatics to lymph nodes, and replicates in macrophages and neutrophils, resulting in lymphopenia, leukopenia, and fever. Subsequent replication occurs in other organs, leading to viremia. Symptoms in horses occur 1–3 weeks after infection, and begin with a fever that may reach as high as 106&nbsp;°F (41&nbsp;°C). The fever usually lasts for 24–48 hours.{{medcn|date=August 2019}}

⚫
Nervous signs appear during the fever that include sensitivity to sound, periods of excitement, and restlessness. Brain lesions appear, causing drowsiness, drooping ears, circling, aimless wandering, [[head pressing]], inability to swallow, and abnormal gait. Paralysis follows, causing the horse to have difficulty raising its head. The horse usually suffers complete paralysis and death 2–4 days after symptoms appear. Mortality rates among horses with the eastern strain range from 70 to 90%.{{medcn|date=August 2019}}
<!-- already cited == See also ==
<!-- already cited == See also ==
* [[Western equine encephalitis virus]]
* [[Western equine encephalitis virus]]
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==Further reading==
==Further reading==
*{{cite web |title=Eastern Equine Encephalitis |publisher=[[Centers for Disease Control and Prevention]] (CDC) |url=https://www.cdc.gov/EasternEquineEncephalitis/index.html|date=2018-12-17 }}
* {{cite web |title=Eastern Equine Encephalitis |publisher=[[Centers for Disease Control and Prevention]] (CDC) |url=https://www.cdc.gov/EasternEquineEncephalitis/index.html|date=2018-12-17 }}
*Source for a portion of this information: {{cite book |first=J.W. |last=Evans |first2=A. |last2=Borton |first3=H.F. |last3=Hintz |first4=L.D. |last4=Van Vleck |title=The Horse |publisher=W.H. Freeman |isbn=978-0716704911 |year=1977 |url-access=registration |url=https://archive.org/details/horse00evan }}
* Source for a portion of this information: {{cite book |first1=J.W. |last1=Evans |first2=A. |last2=Borton |first3=H.F. |last3=Hintz |first4=L.D. |last4=Van Vleck |title=The Horse |publisher=W.H. Freeman |isbn=978-0716704911 |year=1977 |url-access=registration |url=https://archive.org/details/horse00evan }}

⚫
==External links==
* {{Cite web |title=Togaviridae |url=http://www.viprbrc.org/brc/home.do?decorator=toga |publisher=Virus Pathogen Database and Analysis Resource (ViPR)}}


⚫
== External links ==
{{Medical resources
{{Medical resources
| DiseasesDB =
| DiseasesDB =
| ICD10 = {{ICD10|A|83|2|a|80}}
| ICD11 = {{ICD11|1C84}}
| ICD9 = {{ICD9|062.2}}
| ICD10 = {{ICD10|A|83|2|a|80}}
| ICDO =
| ICD9 = {{ICD9|062.2}}
| OMIM =
| ICDO =
| MedlinePlus =
| OMIM =
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| eMedicineTopic =
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| eMedicineTopic =
| MeshID = D020242
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}}
}}

* {{cite web |title=Togaviridae |publisher=Virus Pathogen Database and Analysis Resource (ViPR) |url=http://www.viprbrc.org/brc/home.do?decorator=toga}}
* [http://archives.mc.duke.edu/mcabeard.html Joseph W. Beard Papers at Duke University Medical Center Archives]

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{{DEFAULTSORT:Eastern Equine Encephalitis Virus}}
{{DEFAULTSORT:Eastern Equine Encephalitis Virus}}
[[Category:Alphaviruses]]
[[Category:Alphaviruses]]
[[Category:Animal vaccines]]
[[Category:Animal vaccines]]
[[Category:Animal virology]]
[[Category:Animal viral diseases]]
[[Category:Biological weapons]]
[[Category:Biological weapons]]
[[Category:Bird diseases]]
[[Category:Bird diseases]]

Latest revision as of 22:30, 11 November 2024

Eastern equine encephalitis
SpecialtyInfectious diseases Edit this on Wikidata
Symptomshigh fever, muscle pain, altered mental status, headache, meningeal irritation, photophobia, and seizures
CausesEastern equine encephalitis virus
Risk factorsPeople over the age of 50 or younger than the age of 16 are at greatest risk of developing severe disease.[medical citation needed]
Diagnostic methodCerebrospinal fluid or brain tissue examination
Prognosis~33% fatality rate in severe cases[1]

Eastern equine encephalitis (EEE), commonly called Triple E or sleeping sickness (not to be confused with African trypanosomiasis), is a disease caused by a zoonotic mosquito-vectored Togavirus that is present in North, Central, and South America, and the Caribbean. EEE was first recognized in Massachusetts, United States, in 1831, when 75 horses died mysteriously of viral encephalitis. Epizootics of EEE in horses have continued to occur regularly in the United States. It can also be identified in donkeys and zebras. Rarely, it can also infect humans. Due to the rarity of the disease, its occurrence can cause economic impact beyond the cost of horses and poultry.[2] EEE is found today in the eastern part of the United States and is often associated with coastal plains. It can most commonly be found in East Coast and Gulf Coast states.[1] In Florida, about one to two human cases are reported a year, although over 60 cases of equine encephalitis are reported. In years in which conditions are favorable for the disease, the number of equine cases is over 200.[3] Diagnosing equine encephalitis is challenging because many of the symptoms are shared with other illnesses and patients can be asymptomatic. Confirmations may require a sample of cerebrospinal fluid or brain tissue, although CT scans and MRI scans are used to detect encephalitis. This could be an indication that the need to test for EEE is necessary. If a biopsy of the cerebrospinal fluid is taken, it is sent to a specialized laboratory for testing.[4]

Eastern equine encephalitis virus (EEEV) is closely related to Venezuelan equine encephalitis virus and western equine encephalitis virus.

Signs and symptoms

[edit]

The incubation period for Eastern equine encephalitis virus (EEEV) disease ranges from 4 to 10 days. The illness can progress either systematically or encephalitically, depending on the person's age. Encephalitic disease involves swelling of the brain and can be asymptomatic, while the systemic illness occurs very abruptly. Those with the systemic illness usually recover within 1–2 weeks. While the encephalitis is more common among infants, in adults and children, it usually manifests after experiencing the systemic illness.[1] Symptoms include high fever, muscle pain, altered mental status, headache, meningeal irritation, photophobia, and seizures, which occur 3–10 days after the bite of an infected mosquito. Due to the virus's effect on the brain, patients who survive can be left with mental and physical impairments, such as personality disorders, paralysis, seizures, and intellectual impairment.[1]

Cause

[edit]

Virus

[edit]
Eastern equine encephalitis virus
Colourised TEM micrograph of a mosquito salivary gland: The virus particles (virions) are coloured red. (83,900x magnification)
Colourised TEM micrograph of a mosquito salivary gland: The virus particles (virions) are coloured red. (83,900x magnification)
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Kitrinoviricota
Class: Alsuviricetes
Order: Martellivirales
Family: Togaviridae
Genus: Alphavirus
Species:
Eastern equine encephalitis virus

The causative agent, later identified as an alphavirus, was first isolated from infected horse brains in 1933. In 1938, the first confirmed human cases were identified when 30 children died of encephalitis in the Northeastern United States. These cases coincided with outbreaks in horses in the same regions. The fatality rate in humans is 33%, and currently no cure is known for human infections. This virus has four variations in the types in lineage. The most common to the human disease is group 1, which is considered to be endemic in North America and the Caribbean, while the other three lineages, groups IIA, IIB, and III, are typically found in Central and South America, causing equine illness.[1]

These two clades may actually be distinct viruses.[5] The North American strains appear to be monotypic with a mutation rate of 2.7 × 10−4 substitutions/site/year (s/s/y). It appears to have diverged from the other strains 922 to 4,856 years ago. The other strains are divided into two main clades and a third smaller one. The two main clades diverged between 577 and 2,927 years ago. The mutation rate in the genome has been estimated to be 1.2 × 10−4 s/s/y.[citation needed]

Lifecycle

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EEEV is capable of infecting a wide range of animals, including mammals, birds, reptiles, and amphibians. The virus is maintained in nature through a bird—mosquito (enzootic) cycle. Two mosquito species are primarily involved in this portion of the cycle; they are Culiseta melanura[6] and Culiseta morsitans [Wikidata].[citation needed] These mosquitoes feed on the blood of birds. The frequency of the virus found in nature increases throughout the summer as more birds and more mosquitoes become infected.[citation needed]

Transmission of EEEV to mammals (including humans) occurs via other mosquito species, which feed on the blood of both birds and mammals. These other mosquitoes are referred to as "bridge vectors" because they carry the virus from the avian hosts to other types of hosts, particularly mammals. The bridge vectors include Aedes taeniorhynchus[7], Aedes vexans, Coquillettidia perturbans, Ochlerotatus canadensis, and Ochlerotatus sollicitans. Ochlerotatus canadensis also frequently bites turtles.[citation needed]

Humans, horses, and most other infected mammals do not circulate enough viruses in their blood to infect additional mosquitoes. Some cases of EEE have been contracted through laboratory exposures or from exposure of the eyes, lungs, or skin wounds to brain or spinal cord matter from infected animals.[citation needed]

Prevention

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The disease can be prevented in horses with the use of vaccinations, which are usually given with vaccinations for other diseases, most commonly western equine encephalitis virus, Venezuelan equine encephalitis virus, and tetanus. Most vaccinations for EEE consist of the killed virus. For humans, no vaccine for EEE is available; prevention involves reducing the risk of exposure. Using insect repellent, wearing protective clothing, and reducing the amount of standing water is the best means for prevention.[1]

Treatment

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Magnetic resonance images (MRIs) and computed tomography (CT) neuroradiographs showing lesions in brains of three children with eastern equine encephalitis: A) Results of noncontrast CT scan of the brain of patient 12 on hospital day 2; the neuroradiograph shows subtle hypoattenuation of the left caudate head (arrow) and diencephalic region. B) Axial fluid attenuated inversion recovery image from brain MRI scan of patient 14 on hospital day 2; the image shows abnormal T2 hyperintense regions of the bimesial temporal regions (thick arrows) with accompanying abnormal T2 hyperintense regions of the dorsal pontomesencephalic regions (thin arrows). C, D) FLAIR images from brain MRI scan of patient 15 on hospital day 3. C) Abnormal T2 hyperintense caudate and thalamic nuclei, most prominent on the right (arrow). D) Abnormal T2 hyperintense regions are most prominent in the right parietotemporal gray matter (arrow) and subcortical white matter but are also seen scattered throughout.

No cure for EEE has been found. Treatment consists of corticosteroids, anticonvulsants, and supportive measures (treating symptoms)[8] such as intravenous fluids, tracheal intubation, and antipyretics.[citation needed] About 4% of humans known to be infected develop symptoms, with a total of about six cases per year in the US.[8] A third of these cases die, and many survivors suffer permanent brain damage.[9]

Epidemiology

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United States

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A disease-incidence map for human cases of EEE, 1964–2010

Several states in the Northeast U.S. have had increased virus activity since 2004. Between 2004 and 2006, at least ten human cases of EEE were reported in Massachusetts. In 2006, about 500,000 acres (2,000 km2) in southeastern Massachusetts were treated with mosquito adulticides to reduce the risk of humans contracting EEE. Several human cases were reported in New Hampshire, as well.[10][11]

In July 2012, the virus was identified in a mosquito of the species Coquillettidia perturbans in Nickerson State Park on Cape Cod, Massachusetts. On 28 July 2012, the virus was found in mosquitos in Pittsfield, Massachusetts.[12]

As of September 2019, a notable uptick in cases erupted in New England and Michigan, prompting some health departments to declare an outbreak.[13][14][15][16][17][18][19] As of 31 October 2019, five people died in Michigan,[20][21] three people died in Connecticut,[22] one person died in Rhode Island,[19] one person died in Alabama,[23] one person died in Indiana,[24] and three people died in Massachusetts.[25][26][27] The virus was also found in goats,[28] in turkeys,[29] in deer,[29] and in horses.[30][21][31][19][29]

As of September 2020, there were five confirmed human cases between Massachusetts and Wisconsin.[32] As of October 9, 2020, one person died in Michigan,[33] and one person died in Wisconsin.[34]

In 2024, a man in New Hampshire died due to the virus.[35] In Plymouth Massachusetts, the town closed parks in the evenings due to new cases being found in August 2024.[36] Spraying for mosquitos is being used to reduce the risk of EEE.[37][38][39][40]

Europe

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In October 2007, a citizen of Livingston, West Lothian, Scotland became the first European victim of this disease. The man had visited New Hampshire during the summer of 2007, on a fishing vacation, and was diagnosed as having EEE on 13 September 2007. He fell ill with the disease on 31 August 2007, just one day after flying home, and later fell into a coma.[41] He later awoke from the coma with severe brain injuries.[42]

Biological weapon

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EEEV was one of more than a dozen agents that the United States researched as potential biological weapons before the nation suspended its biological-weapons program in 1969, a few years before signing (1972) and then ratifying (1975) the Biological Weapons Convention.[43]

Other animals

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From its natural reservoir in birds, EEEV is known to infect reptiles and amphibians as well as both humans and other mammals, including horses.[44]

Horses

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After inoculation by the vector, the virus travels via lymphatics to lymph nodes, and replicates in macrophages and neutrophils, resulting in lymphopenia, leukopenia, and fever. Subsequent replication occurs in other organs, leading to viremia. Symptoms in horses occur 1–3 weeks after infection, and begin with a fever that may reach as high as 106 °F (41 °C). The fever usually lasts for 24–48 hours.[medical citation needed]

Nervous signs appear during the fever that include sensitivity to sound, periods of excitement, and restlessness. Brain lesions appear, causing drowsiness, drooping ears, circling, aimless wandering, head pressing, inability to swallow, and abnormal gait. Paralysis follows, causing the horse to have difficulty raising its head. The horse usually suffers complete paralysis and death 2–4 days after symptoms appear. Mortality rates among horses with the eastern strain range from 70 to 90%.[medical citation needed]

References

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  1. ^ a b c d e f "About Eastern Equine Encephalitis". Centers for Disease Control and Prevention (CDC). 29 August 2024. Retrieved 8 September 2024.
  2. ^ "Eastern Equine Encephalomyelitis" (PDF). United States Department of Agriculture Animal and Plant Health Inspection Service. United States Department of Agriculture (USDA). Archived from the original (PDF) on 3 February 2017. Retrieved 1 May 2017.
  3. ^ "Eastern Equine Encephalitis". Florida Health. Retrieved 30 April 2017.
  4. ^ Deresiewicz RL, Thaler SJ, Hsu L, Zamani AA (1997). "Clinical and neuroradiographic manifestations of eastern equine encephalitis". N. Engl. J. Med. 336 (26): 1867–74. doi:10.1056/NEJM199706263362604. PMID 9197215.
  5. ^ Arrigo NC, Adams AP, Weaver SC (January 2010). "Evolutionary patterns of eastern equine encephalitis virus in North versus South America suggest ecological differences and taxonomic revision". J. Virol. 84 (2): 1014–25. doi:10.1128/JVI.01586-09. PMC 2798374. PMID 19889755.
  6. ^ "Transmission of Eastern Equine Encephalitis Virus". Eastern Equine Encephalitis Virus. U.S. Centers for Disease Control and Prevention. 20 May 2024. Retrieved 26 August 2024.
  7. ^ Kelser R (1937). "Transmission of the Virus of Equine Encephalomy-elîtis by Aëdes taeniorhynchus". Science. 85–2198 (2198): 178. Bibcode:1937Sci....85..178K. doi:10.1126/science.85.2198.178. PMID 17732932. S2CID 26044382.
  8. ^ a b "Eastern Equine Encephalitis". Centers for Disease Control and Prevention (CDC). 16 August 2010. Retrieved 7 August 2012.
  9. ^ "Eastern Equine Encephalitis Fact Sheet". Centers for Disease Control and Prevention (CDC). 16 August 2010. Retrieved 30 August 2015.
  10. ^ Zheng Y (16 August 2008). "Mosquito-borne virus infects 2d in Mass". The Boston Globe.
  11. ^ Zheng Y (31 August 2006). "Middleborough boy with EEE dies". The Boston Globe. Archived from the original on 2 September 2006. Retrieved 31 August 2006.
  12. ^ Kane T (27 July 2012). "Rare, deadly virus found in mosquitoes in Pittsfield". News10. Archived from the original on 30 July 2012.
  13. ^ Andersen T, McDonald D (6 September 2019). "Two more EEE human cases reported, raising the state's count to seven". The Boston Globe. Archived from the original on 14 November 2019. Retrieved 6 September 2019.
  14. ^ "Why Is EEE Highest In Southeastern Massachusetts?". CBS Boston. 22 August 2019. Retrieved 22 August 2019.
  15. ^ "Second Human Case Of EEE Confirmed In Mass.; 10 More Towns Now At Critical Risk". CBS Boston. 16 August 2019. Retrieved 22 August 2019.
  16. ^ Seltz J (13 August 2019). "It's code red for EEE in nine communities south of Boston". The Boston Globe. Retrieved 22 August 2019.
  17. ^ Congi S (13 August 2019). "Massachusetts man infected with EEE now in coma, family says". WCVB-TV. Retrieved 22 August 2019.
  18. ^ LaPook J (21 September 2019). "7 dead from rare disease spread by mosquitoes". CBS News. Retrieved 21 September 2019.
  19. ^ a b c Almasy S (2 October 2019). "Connecticut Eastern equine encephalitis death is 10th nationwide". CNN. Archived from the original on 14 November 2019. Retrieved 14 November 2019.
  20. ^ Miller K (2 October 2019). "Fourth person dies from mosquito-borne illness in Michigan". mlive. Retrieved 3 October 2019.
  21. ^ a b Mahieu D (15 October 2019). "Fifth person in Michigan dies from Eastern Equine Encephalitis". UpNorthLive. Archived from the original on 14 November 2019. Retrieved 14 November 2019.
  22. ^ Cuda A (1 September 2019). "Third person in state dies from EEE". Connecticut Post. Archived from the original on 17 October 2019. Retrieved 16 October 2019.
  23. ^ Gore L (28 October 2019). "Mosquito-borne virus kills 1 in Alabama: What to know about EEE". al. Archived from the original on 14 November 2019. Retrieved 14 November 2019.
  24. ^ "1st Eastern Equine Encephalitis Human Death Reported in Indiana". News18. 20 October 2019. Archived from the original on 14 November 2019. Retrieved 14 November 2019.
  25. ^ Klein A (26 September 2019). "Mass. Health Officials Say 12th Person Has EEE, 1 Fewer Death". NBC10 Boston. Archived from the original on 14 November 2019. Retrieved 14 November 2019.
  26. ^ Pescaro M, Klein A (25 September 2019). "UPDATE: Mass. Health Officials Give New Info on EEE-Related Deaths". NBC10 Boston. Archived from the original on 14 November 2019. Retrieved 14 November 2019.
  27. ^ "Mass. retracts number of EEE deaths; confirms 12th human case of virus". The Boston Globe. 26 September 2019. Archived from the original on 14 November 2019. Retrieved 14 November 2019.
  28. ^ Anderson DJ (17 August 2019). "A 2nd Person In Mass. Is Diagnosed With Mosquito-Linked EEE Disease". WBUR-FM. Retrieved 22 August 2019.
  29. ^ a b c "Pennsylvania Game Commission advises hunters to take precautions against EEE virus". Pittsburgh Tribune-Review. 22 October 2019. Archived from the original on 14 November 2019. Retrieved 14 November 2019.
  30. ^ "18 Louisiana Horses Confirmed Positive for EEE or WNV". The Horse. 21 August 2019. Retrieved 22 August 2019.
  31. ^ Mulder J (1 October 2019). "Eastern equine encephalitis kills another horse in Oswego County". syracuse. Archived from the original on 14 November 2019. Retrieved 14 November 2019.
  32. ^ "Michiganders urged to stay indoors as officials race to stop the spread of a dangerous mosquito-borne disease". CNN. 17 September 2020. Retrieved 26 October 2020.
  33. ^ "West Michigan resident with EEE dies". mlive. 2 October 2020. Retrieved 26 October 2020.
  34. ^ "Wisconsin woman dies of rare disease carried by mosquitoes". Milwaukee Journal Sentinel. Retrieved 25 October 2020.
  35. ^ "New Hampshire resident dies from EEE, a rare mosquito-borne virus". NBC News. 28 August 2024. Retrieved 2 September 2024.
  36. ^ https://www.plymouth-ma.gov/DocumentCenter/View/6479/Plymouth-Park-and-Field-Closures---EEE-Press-Release?bidId=
  37. ^ "Mosquito control and spraying". Mass.gov. 31 August 2024. Retrieved 1 September 2024.
  38. ^ "EEE (Eastern Equine Encephalitis)". Mass.gov. Retrieved 1 September 2024.
  39. ^ "State officials announce plans to spray for mosquitoes in sections of Worcester and Plymouth counties due to EEE". Mass.gov. Retrieved 1 September 2024.
  40. ^ "Massachusetts arbovirus update". Mass.gov. Retrieved 1 September 2024.
  41. ^ "Man in coma after mosquito bite". BBC News Online. 8 October 2007.
  42. ^ "Family thrilled by recovery of killer virus victim". The Scotsman. 22 December 2007. Retrieved 4 February 2020.
  43. ^ "Chemical and Biological Weapons: Possession and Programs Past and Present" (PDF). James Martin Center for Nonproliferation Studies, Middlebury College. March 2008.
  44. ^ Young A (28 August 2020). "Eastern Equine Encephalitis (EEE)". ceh.vetmed.ucdavis.edu. Retrieved 5 November 2022.

Further reading

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  • "Togaviridae". Virus Pathogen Database and Analysis Resource (ViPR).
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