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{{Short description|Dutch behavioral neurogeneticist}}
{{Use dmy dates|date=February 2013}}
{{Use dmy dates|date=April 2022}}
{{Infobox scientist
{{Infobox scientist
| name = Wim E. Crusio
| name = Wim E. Crusio
Line 6: Line 7:
| birth_date = {{Birth date and age|df=yes|1954|12|20}}
| birth_date = {{Birth date and age|df=yes|1954|12|20}}
| birth_place = [[Bergen op Zoom]], The [[Netherlands]]
| birth_place = [[Bergen op Zoom]], The [[Netherlands]]
| native_name = Wilhelmus Elisabeth Crusio
| death_date =
| death_date =
| death_place =
| death_place =
| residence = [[Pompignac]], [[France]]
| citizenship = Dutch
| citizenship = Dutch
| nationality =
| nationality =
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| workplaces = [[Radboud University Nijmegen]], [[University of Heidelberg]], [[French National Centre for Scientific Research]] (CNRS; [[Paris]], [[Orléans|Orleans]], and [[Talence|Talence (Bordeaux)]]), [[University of Massachusetts Medical School]]
| workplaces = [[Radboud University Nijmegen]], [[University of Heidelberg]], [[French National Centre for Scientific Research]] (CNRS; [[Paris]], [[Orléans|Orleans]], and [[Talence|Talence (Bordeaux)]]), [[University of Massachusetts Medical School]]
| alma_mater = [[Radboud University Nijmegen]]
| alma_mater = [[Radboud University Nijmegen]]
| thesis_title = Olfaction and behavioral responses to novelty in mice: a quantitative-genetic analysis
| thesis_url = http://repository.ubn.ru.nl/bitstream/handle/2066/148360/mmubn000001_027651975.pdf?sequence=1
| thesis_year = 1984
| doctoral_advisor = [[Hans van Abeelen]]
| doctoral_advisor = [[Hans van Abeelen]]
| academic_advisors = Bram van Overbeeke, <br /> [[Hendrik de Wit]], <br /> [[Victor Westhoff]]
| academic_advisors = Bram van Overbeeke, <br /> [[Hendrik de Wit]], <br /> [[Victor Westhoff]]
| doctoral_students = Laure Jamot, <br /> Abdelkader Lagmouch, <br /> Yann Mineur, <br /> Maude Bernardet
| doctoral_students =
| notable_students = Frans Sluyter
| notable_students =
| known_for = Behavioral neurogenetics of the [[hippocampus]], [[mouse]] [[animal model|models]] of [[Neuropsychiatry|neuropsychiatric disorders]]
| known_for = Behavioral neurogenetics of the [[hippocampus]], [[mouse]] [[animal model|models]] of [[Neuropsychiatry|neuropsychiatric disorders]]
| author_abbrev_bot = Crusio
| author_abbrev_bot = Crusio
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| influenced =
| influenced =
| awards = IBANGS Distinguished Service Award
| awards = IBANGS Distinguished Service Award
| website = {{URL|https://wimcrusio.com/}}
}}
}}
{{wikispecies|Wim Crusio}}
{{wikispecies|Wim Crusio}}
'''Wim E. Crusio''' is a [[Dutch people|Dutch]] [[Behavioural genetics|behavioral]] [[Neurogenetics|neurogeneticist]] and a [[Research director|directeur de recherche]] (research director) with the [[French National Centre for Scientific Research]] in [[Talence]], France.
'''Wim E. Crusio''' (born '''Wilhelmus Elisabeth Crusio''' on 20 December 1954) is a [[Dutch people|Dutch]] [[Behavioural genetics|behavioral]] [[Neurogenetics|neurogeneticist]] and a ''[[Centre national de la recherche scientifique#Employment|directeur de recherche]]'' (research director) with the [[French National Centre for Scientific Research]] in [[Talence]], France.


== Education and career ==
== Education and career ==
Crusio obtained a [[Master of Science|master's degree]] and then a [[Doctor of Philosophy|Ph.D.]] from the [[Radboud University Nijmegen]] in 1979 and 1984, respectively. For his master's degree, he performed research in [[Behavioural genetics|behavior genetics]],<ref name=pmid733951>{{cite journal |author=Schoots AF, Crusio WE, van Abeelen JH |title=Zinc-induced peripheral anosmia and exploratory behavior in two inbred mouse strains |journal=[[Physiology and Behavior]] |volume=21 |issue=5 |pages=779–784 |year=1978 |month=November |pmid=733951 |doi=10.1016/0031-9384(78)90018-5}}</ref> [[plant taxonomy]],<ref name=Anubias>{{cite journal|last=Crusio|first=W.|year=1979|title=A revision of ''Anubias'' Schott (Araceae). ([[Primitiae Africanae|Primitiae Africanae XII]])|journal=Mededelingen Landbouwhogeschool Wageningen|volume=79|issue=14|pages=1–48}}</ref> and [[phytosociology|vegetation science]].<ref name=Sykora>{{cite journal |author=Sykora, KV |title=A synecological study of the Lolio‑Potentillion anserinae Tuexen 1947 by means of permanent transects. II: Riveri­ne eurysaleutic habitats |journal=Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen. Series C, Biological and medical sciences |volume=87 |issue=2 |pages=181–230 |year=1984}}</ref> His ''[[Anubias]]'' revision continues to generate interest.<ref>{{cite journal |title=Protokoll der Mitgliederversammlung 2009 des Arbeitskreises Wasserpflanzen in Dresden |journal=[[Aqua Planta]] |year=2009 |first=Wolf-Dieter |last=Klix |volume=34 |issue=4 |pages=150–151| url=http://www.arbeitskreis-wasserpflanzen.de/aquaplanta.php |accessdate=2010-08-22 |quote=Announcement of re-issue on CD of 1987 German edition of ''Anubias'' revision}}</ref> His work in plant taxonomy continued for several more years, with publications on the [[genus]] ''[[Samolus]]''<ref>{{cite journal |author=Crusio WE|title=Het geslacht ''Samolus'' L |journal=Communications of the Dutch Waterplant Society |volume=2 |pages=13–25 |language=Dutch |date=20 February 1982}}</ref><ref>{{cite journal |author=Crusio WE|title=Notes on the genus ''Samolus'' L. (Primulaceae) |journal=Communications of the Dutch Waterplant Society |volume=6 |pages=13–16 |date=26 May 1984}}</ref> and the description of a new species of the [[Araceae|Aroid]] genus ''[[Lagenandra]]'', ''[[Lagenandra dewitii|L.dewitii]]'', in 1986.<ref name=Ldewitii>{{cite journal |author=Crusio W.E. and de Graaf A. |title=''Lagenandra dewitii'' Crusio et de Graaf (Araceae), eine neue Art aus Sri Lanka |journal=Aqua Planta |volume=11 |issue=2 |pages=56–59 |year=1986 |month=April |language=German}}</ref> For his PhD thesis, Crusio studied the inheritance of the effects of [[anosmia]] on [[exploration|exploratory behavior]] of mice, and more in general the [[genetic architecture]] of exploratory behavior, using [[quantitative genetics|quantitative-genetic]] methods such as the [[diallel cross]].<ref name=thesis>{{cite book |author=Crusio, WE |title= Olfaction and behavioral responses to novelty in mice: A quantitative-genetic analysis |publisher=Krips Repro |location=[[Meppel]] |year=1984 |pages=viii+146+78}}</ref> From 1984 to 1987, Crusio worked as a [[postdoctoral research|postdoc]] at the [[University of Heidelberg]], supported by a [[NATO]] Science Fellowship<ref name=CV>{{cite web |url=http://www.mousebehavior.com/vitae_wec.htm |title=Curriculum Vitae Wim E. Crusio |work= |accessdate=2009-08-15}}</ref> and an [[Alexander von Humboldt Foundation|Alexander von Humboldt Research Fellowship]].<ref name=avh>{{cite web |url=http://www.avh.de/automat_db/pub_humboldtiana2.humboldtiana_index_pub?p_year=2005&p_group=1&p_fg2=2G |title=Publications by Humboldt Research Fellows from abroad in 2005: Biosciences, Life Sciences |work= |accessdate=2009-08-11}}</ref> During 1988, Crusio spent a year in [[Paris]], [[France]], supported by a fellowship from the [[Fyssen Foundation]].<ref name=Fyssen>{{cite journal |title=Liste des boursiers 1987/1988 |journal=Annales de la Fondation Fyssen |year=1989 |volume=4|id= }}</ref> He then returned to Heidelberg as a senior research scientist before being recruited as ''chargé de recherche'' by the CNRS, initially working in an institute of the [[Paris Descartes University|Université René Descartes]] (Paris V) and later moving to the CNRS [[campus]] in [[Orléans]], having been promoted to ''directeur de recherche''.<ref name=CV /> In 2000 he became full [[professor]] of [[psychiatry]] at the [[University of Massachusetts Medical School]] in [[Worcester, Massachusetts]], returning to the CNRS in 2005 as a group leader in the [[University of Bordeaux|Centre de Neurosciences Intégratives et Cognitives]] in [[Talence]], a suburb of [[Bordeaux]].<ref name=CV /><ref name=CNIC>{{cite web |url=http://www.cnic.u-bordeaux1.fr/rubrique.php3?id_rubrique=29 |deadurl=yes |archiveurl=http://web.archive.org/web/20071030031635/http://www.cnic.u-bordeaux1.fr/rubrique.php3?id_rubrique=29 |archivedate=2007-10-30 |title=CNIC UMR5228 - Equipe 3 - Neurogénétique comportementale |language=French |work= |accessdate=2009-08-15}}</ref><ref name=INB>{{cite web |url=http://www.inb.u-bordeaux2.fr/siteneuro2/pages/archiindex/Crusio/CrusioWim.php |title=Nouvel arrivant à l'INB, aujourd'hui : Wim CRUSIO |author=Deris, Yves |publisher=Institut des Neurosciences de Bordeaux |accessdate=2009-08-23 |language=French}}</ref> He is currently adjunct director of the Institut de Neurosciences Cognitives et Intégratives d'Aquitaine.<ref>{{cite web |url=http://www.incia.u-bordeaux1.fr/spip.php?article168 |title=Crusio Wim |publisher=The Aquitaine Institute for Cognitive and Integrative Neuroscience |work= |accessdate=2012-12-29}}</ref>
Crusio received his bachelor's degree in biology from [[Radboud University Nijmegen]] in 1975, where he went on to obtain a [[Master of Science|master's degree]] and then a [[Doctor of Philosophy|PhD]] in 1979 and 1984, respectively.<ref name="blogcv">{{Cite web |url=http://www.mousebehavior.com/CV-WEC.pdf |title=Wim E. Crusio Curriculum Vitae |website=Wim E. Crusio Blog |date=February 2016 |archive-url=https://web.archive.org/web/20171107005135/http://www.mousebehavior.com/CV-WEC.pdf |archive-date=7 November 2017 |access-date=15 August 2018}}</ref> His ''[[Anubias]]'' revision, which was originally published in 1979,<ref name="blogcv" /> was translated in German<ref>{{cite journal |last1=Brünner |first1=Gerhard |title=Crusio, Wim: Die Gattung Anubias (Araceae) |journal=Aquarien Magazin |date=1987 |volume=21 |issue=7 |department=Für Ihre Bücherei |language=de}}</ref> and continues to engender interest.<ref>{{cite journal |title=Protokoll der Mitgliederversammlung 2009 des Arbeitskreises Wasserpflanzen in Dresden |journal=[[Aqua Planta]] |year=2009 |first=Wolf-Dieter |last=Klix |volume=34 |issue=4 |pages=150–151 |url=http://www.arbeitskreis-wasserpflanzen.de/aquaplanta.php |access-date=2010-08-22 |quote=Announcement of re-issue on CD of 1987 German edition of ''Anubias'' revision |language=de |archive-date=7 October 2010 |archive-url=https://web.archive.org/web/20101007080739/http://arbeitskreis-wasserpflanzen.de/aquaplanta.php |url-status=dead }}</ref> For his PhD thesis, Crusio studied the inheritance of the effects of [[anosmia]] on [[exploration|exploratory behavior]] of mice, and more in general the [[genetic architecture]] of exploratory behavior, using [[quantitative genetics|quantitative-genetic]] methods such as the [[diallel cross]].<ref name="thesis">{{cite book |url=http://repository.ubn.ru.nl/handle/2066/148360 |title=Olfaction and behavioral responses to novelty in mice: A quantitative-genetic analysis |publisher=Krips Repro |year=1984 |location=[[Meppel]] |pages=viii+146+78 |author=Crusio, WE |access-date=31 July 2016 |archive-date=14 August 2016 |archive-url=https://web.archive.org/web/20160814090047/http://repository.ubn.ru.nl/handle/2066/148360 |url-status=live }}</ref> From 1984 to 1987, Crusio worked as a [[postdoctoral research|postdoc]] at the [[University of Heidelberg]], supported by a [[NATO]] Science Fellowship<ref name="CV">{{Cite web |url=http://www.mousebehavior.com/vitae_wec.htm |title=Curriculum Vitae Wim E. Crusio |archive-url=https://web.archive.org/web/20170130230232/http://mousebehavior.com/vitae_wec.htm |archive-date=30 January 2017 |access-date=15 August 2018}}</ref> and an [[Alexander von Humboldt Foundation|Alexander von Humboldt Research Fellowship]].<ref name=avh>{{cite web |url=http://www.avh.de/automat_db/pub_humboldtiana2.humboldtiana_index_pub?p_year=2005&p_group=1&p_fg2=2G |title=Publications by Humboldt Research Fellows from abroad in 2005: Biosciences, Life Sciences |access-date=2009-08-11 |archive-date=27 September 2011 |archive-url=https://web.archive.org/web/20110927223351/http://www.avh.de/automat_db/pub_humboldtiana2.humboldtiana_index_pub?p_year=2005&p_group=1&p_fg2=2G |url-status=dead }}</ref> During 1988, Crusio spent a year in [[Paris]], [[France]], supported by a fellowship from the [[Fyssen Foundation]].<ref name=Fyssen>{{cite journal |title=Liste des boursiers 1987/1988 |journal=[[Annales de la Fondation Fyssen]] |year=1989 |volume=4 }}</ref> He then returned to Heidelberg as a senior research scientist before being recruited as ''chargé de recherche'' by the CNRS, initially working in an institute of the [[Paris Descartes University|Université René Descartes]] (Paris V) and later moving to the CNRS [[campus]] in [[Orléans]], having been promoted to ''directeur de recherche''.<ref name="CV" /> In 2000 he became full [[professor]] of [[psychiatry]] at the [[University of Massachusetts Medical School]] in [[Worcester, Massachusetts]], returning to the CNRS in 2005 as a group leader in the [[University of Bordeaux|Centre de Neurosciences Intégratives et Cognitives]] in [[Talence]], a suburb of [[Bordeaux]].<ref name="CV" /><ref name=CNIC>{{cite web |url=http://www.cnic.u-bordeaux1.fr/rubrique.php3?id_rubrique=29 |url-status=dead |archive-url=https://web.archive.org/web/20071030031635/http://www.cnic.u-bordeaux1.fr/rubrique.php3?id_rubrique=29 |archive-date=2007-10-30 |title=CNIC UMR5228 – Equipe 3 – Neurogénétique comportementale |language=fr |access-date=2009-08-15}}</ref><ref name=INB>{{cite web |url=http://www.inb.u-bordeaux2.fr/siteneuro2/pages/archiindex/Crusio/CrusioWim.php |title=Nouvel arrivant à l'INB, aujourd'hui : Wim CRUSIO |author=Deris, Yves |publisher=Institut des Neurosciences de Bordeaux |access-date=2009-08-23 |language=fr |archive-date=17 July 2009 |archive-url=https://web.archive.org/web/20090717061310/http://www.inb.u-bordeaux2.fr/siteneuro2/pages/archiindex/Crusio/CrusioWim.php |url-status=dead }}</ref> He is currently adjunct director of the Institut de Neurosciences Cognitives et Intégratives d'Aquitaine.<ref>{{cite web |url=http://www.incia.u-bordeaux1.fr/spip.php?article168 |title=Crusio Wim |publisher=The Aquitaine Institute for Cognitive and Integrative Neuroscience |access-date=2012-12-29 |archive-date=21 October 2014 |archive-url=https://web.archive.org/web/20141021164838/http://www.incia.u-bordeaux1.fr/spip.php?article168 |url-status=live }}</ref>


== Research ==
== Research ==

=== Exploratory behavior ===
When confronted with a novel environment, animals from non-sessile non-[[predation|predatory]] animal species will often engage in exploratory behavior. Together with his mentor [[Hans van Abeelen]], Crusio [[hypothesis|hypothesized]] that, on the one hand, this would be advantageous (as it would enable animals to find resources, such as water, food, etc.), but on the other hand disadvantageous (because moving around in unfamiliar territory will render an animal vulnerable to predation).<ref name=pmid3943979>{{cite journal |author=Crusio WE, van Abeelen JH |title=The genetic architecture of behavioural responses to novelty in mice |journal=[[Heredity (journal)|Heredity]] |volume=56 |issue=1 |pages=55–63 |year=1986 |month=February |pmid=3943979 |doi= 10.1038/hdy.1986.8|url= }}</ref> Such [[stabilizing selection]] would be expected to lead to a genetic architecture characterized by [[ambidirectional dominance]].<ref>{{cite book |editor1-first=JHF |editor1-last=van Abeelen |editor1-link=Hans van Abeelen |last1=Broadhurst | first1=PL | last2=Jinks | first2=JL | authorlink2=John L. Jinks | title=The Genetics of Behaviour |chapter=What genetical architecture can tell us about the natural selection of behavioural traits | publisher=North Holland |location=Amsterdam| year=1974 |isbn=0-7204-7137-0 |pages=43–63 |oclc=1365968}}</ref> This was indeed found both for mice<ref name=pmid3943979/><ref name=pmid2930636>{{cite journal |author=Crusio WE, Schwegler H, van Abeelen JH |title=Behavioral responses to novelty and structural variation of the hippocampus in mice. I. Quantitative-genetic analysis of behavior in the open-field |journal=[[Behavioural Brain Research]] |volume=32 |issue=1 |pages=75–80 |year=1989 |month=February |pmid=2930636 |doi= 10.1016/S0166-4328(89)80074-9|url= }}</ref><ref name=pmid11682103>{{cite journal |author=Crusio WE |title=Genetic dissection of mouse exploratory behaviour |journal=[[Behavioural Brain Research]] |volume=125 |issue=1–2 |pages=127–132 |year=2001 |month=November |pmid=11682103 |doi= 10.1016/S0166-4328(01)00280-7|url= }}</ref> and for [[Paradise fish]].<ref name=pmid2256892>{{cite journal |author=Gerlai R, Crusio WE, Csányi V |title=Inheritance of species-specific behaviors in the paradise fish (''Macropodus opercularis''): A diallel study |journal=Behavior Genetics |volume=20 |issue=4 |pages=487–498 |year=1990 |month=July |pmid=2256892 |doi= 10.1007/BF01067715|url= }}</ref>


=== Hippocampal mossy fibers ===
=== Hippocampal mossy fibers ===

During his postdoc, Crusio became interested in the inheritance of [[neuroanatomy|neuroanatomical]] variations in the mouse [[hippocampus]], showing that about 50% of the variation found between different [[inbred strain|inbred mouse strains]] in the sizes of their intra- and infrapyramidal [[mossy fiber (hippocampus)|mossy fiber]] (IIPMF) projections could be [[heritability|attributed to heredity]]. It had previous been shown by Herbert Schwegler and Hans-Peter Lipp that these variations are [[correlation|correlated]] with the capacity of mice to master a [[Operant conditioning#Avoidance learning|two-way active avoidance task]], animals with smaller projections learning much faster than animals with larger IIPMF.<ref name=pmid7292015>{{cite journal |author=Schwegler H, Lipp HP, Van der Loos H, Buselmaier W |title=Individual hippocampal mossy fiber distribution in mice correlates with two-way avoidance performance |journal=[[Science (journal)|Science]] |volume=214 |issue=4522 |pages=817–819 |year=1981 |month=November |pmid=7292015 |doi= 10.1126/science.7292015|url=http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=7292015 |accessdate=2009-08-14}}</ref><ref name=pmid7231813>{{cite journal |author=Schwegler H, Lipp HP |title=Is there a correlation between hippocampal mossy fiber distribution and two-way avoidance performance in mice and rats? |journal=[[Neuroscience Letters]] |volume=23 |issue=1 |pages=25–30 |year=1981 |month=April |pmid=7231813 |doi= |url= }}</ref> Together with Schwegler and Lipp, Crusio showed that an inverse correlation, that is, animals with larger IIPMF learning better, could be found for [[spatial learning]] in a [[radial arm maze]] task.<ref name=pmid3427419>{{cite journal |author=Crusio WE, Schwegler H, Lipp HP |title=Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution |journal=[[Brain Research]] |volume=425 |issue=1 |pages=182–185 |year=1987 |month=November |pmid=3427419 |doi= 10.1016/0006-8993(87)90498-7|url=http://linkinghub.elsevier.com/retrieve/pii/0006-8993(87)90498-7 |accessdate=2009-08-14}}</ref><ref name=pmid2333144>{{cite journal |author=Schwegler H, Crusio WE, Brust I |title=Hippocampal mossy fibers and radial-maze learning in the mouse: a correlation with spatial working memory but not with non-spatial reference memory |journal=[[Neuroscience (journal)|Neuroscience]] |volume=34 |issue=2 |pages=293–298 |year=1990 |pmid=2333144 |doi= 10.1016/0306-4522(90)90139-U|url=http://linkinghub.elsevier.com/retrieve/pii/0306-4522(90)90139-U |accessdate=2009-08-14}}</ref> This correlation was amenable to experimental manipulation by inducing early postnatal [[hyperthyroidism|hyperthyroidy]] by injecting pups with [[thyroxine]], which results in an enlargement of the IIPMF projection.<ref name=pmid887162>{{cite journal |author=Lauder JM, Mugnaini E |title=Early hyperthyroidism alters the distribution of mossy fibres in the rat hippocampus |journal=[[Nature (journal)|Nature]] |volume=268 |issue=5618 |pages=335–337 |year=1977 |month=July |pmid=887162 |doi= 10.1038/268335a0|url= }}</ref> As expected, when mice from a strain with scant IIPMF projections were rendered hyperthyroid, they showed enlarged IIPMF and improved learning ability on the radial maze.<ref name=pmid2066776>{{cite journal |author=Schwegler H, Crusio WE, Lipp HP, Brust I, Mueller GG |title=Early postnatal hyperthyroidism alters hippocampal circuitry and improves radial-maze learning in adult mice |journal=[[Journal of Neuroscience]] |volume=11 |issue=7 |pages=2102–2106 |year=1991 |month=July |pmid=2066776 |doi= |url=http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=2066776 |accessdate=2009-08-14}}</ref><ref name=pmid1946727>{{cite journal |author=Crusio WE, Schwegler H |title=Early postnatal hyperthyroidism improves both working and reference memory in a spatial radial-maze task in adult mice |journal=[[Physiology & Behavior]] |volume=50 |issue=1 |pages=259–261 |year=1991 |month=July |pmid=1946727 |doi= 10.1016/0031-9384(91)90530-2|url=http://linkinghub.elsevier.com/retrieve/pii/0031-9384(91)90530-2 |accessdate=2009-08-14}}</ref> Taken together, Crusio and collaborators think that it is highly likely that this correlation is [[causality|causal]],<ref name=pmid15916698>{{cite journal |author=Crusio WE, Schwegler H |title=Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice |journal=[[Behavioral and Brain Functions]] |volume=1 |issue=3 |pages=1–11 |year=2005 |month=April |pmid=15916698 |doi=10.1186/1744-9081-1-3 |url= |pmc=1143776}}</ref> although this is not universally accepted.<ref>{{cite book |editor1-first=P. |editor1-last=Andersen |editor1-link=Per Andersen |editor2-first=R. |editor2-last=Morris |editor2-link=Richard G. Morris |editor3-first=D. |editor3-last=Amaral |editor3-link=David Amaral |editor4-first=T. |editor4-last=Bliss |editor4-link=Tim Bliss |editor5-last=O'Keefe |editor5-first=J. | title=The Hippocampus Book |chapter=Theories of hippocampal function | publisher=Oxford University Press |location=Oxford, UK| year=2007 |isbn=978-0-19-510027-3 |pages=581–713 |oclc= |editor5-link=John O'Keefe (neuroscientist) |last=Morris | first=R.}}</ref>
Crusio and his collaborators found that [[neuroanatomy|neuroanatomical]] variations in the mouse [[hippocampus]], in particular the sizes of their intra- and infrapyramidal [[mossy fiber (hippocampus)|mossy fiber]]s (IIPMF) correlated with learning performance.<ref name=Chapouthier>{{cite book |title=La Biologie de la Mémoire |publisher=[[Presses Universitaires de France]] |series=Que sais-je? |last1=Chapouthier |first1=Georges |author-link=Georges Chapouthier |year=1994 |pages=128 |language=fr |isbn=2-13-046261-8}}</ref> Together with Herbert Schwegler and Hans-Peter Lipp, Crusio showed that an inverse correlation, that is, animals with larger IIPMF learn better, could be found for [[spatial learning]] in a [[radial arm maze]] task.<ref name=pmid3427419>{{cite journal |title=Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution |journal=[[Brain Research]] |volume=425 |issue=1 |pages=182–185 |date=November 1987 |pmid=3427419 |doi= 10.1016/0006-8993(87)90498-7|last1=Crusio |first1=W. E. |last2=Schwegler |first2=H |last3=Lipp |first3=H. P. |s2cid=39198617 }}</ref><ref name=pmid2333144>{{cite journal |title=Hippocampal mossy fibers and radial-maze learning in the mouse: a correlation with spatial working memory but not with non-spatial reference memory |journal=[[Neuroscience (journal)|Neuroscience]] |volume=34 |issue=2 |pages=293–298 |year=1990 |pmid=2333144 |doi= 10.1016/0306-4522(90)90139-U|last1=Schwegler |first1=H |last2=Crusio |first2=W. E. |last3=Brust |first3=I |s2cid=9557091 }}</ref><ref>{{cite book | url=https://books.google.com/books?id=CTES09IWtm0C&pg=PA138 | title=What's Wrong with My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice | publisher=John Wiley & Sons | author=Crawley, Jacqueline | year=2007 | pages=138 | author-link=Jacqueline Crawley | isbn=9780470119044 | access-date=8 February 2015 | archive-date=10 May 2016 | archive-url=https://web.archive.org/web/20160510175836/https://books.google.com/books?id=CTES09IWtm0C&pg=PA138 | url-status=live }}</ref> Taken together, Crusio and collaborators think that it is highly likely that this correlation is [[causality|causal]],<ref name=pmid15916698>{{cite journal|title=Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice |journal=[[Behavioral and Brain Functions]] |volume=1 |issue=3 |pages=3 |date=April 2005 |pmid=15916698 |doi=10.1186/1744-9081-1-3 |pmc=1143776|last1=Crusio |first1=W. E. |last2=Schwegler |first2=H |doi-access=free }}</ref> although this is not universally accepted.<ref>{{cite book |editor1-first=P. |editor1-last=Andersen |editor1-link=Per Andersen |editor2-first=R. |editor2-last=Morris |editor2-link=Richard G. Morris |editor3-first=D. |editor3-last=Amaral |editor3-link=David Amaral |editor4-first=T. |editor4-last=Bliss |editor4-link=Tim Bliss |editor5-last=O'Keefe |editor5-first=J. | title=The Hippocampus Book |chapter=Theories of hippocampal function | publisher=Oxford University Press |location=Oxford, UK| year=2007 |isbn=978-0-19-510027-3 |pages=581–713 |editor5-link=John O'Keefe (neuroscientist) |last=Morris | first=R.}}</ref>


=== Mouse model of depression ===
=== Mouse model of depression ===
When mice are exposed to unpredictable [[Chronic (medicine)|chronic]] mild [[chronic stress|stress]] (UCMS), they start exhibiting symptoms reminiscent of [[major depressive disorder]] in humans.<ref name=pmid9452163>{{cite journal |author=Willner P |title=Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation |journal=[[Psychopharmacology]] |volume=134 |issue=4 |pages=319–329 |year=1997 |month=December |pmid=9452163 |doi= 10.1007/s002130050456|url=http://link.springer.de/link/service/journals/00213/bibs/7134004/71340319.htm |accessdate=2009-08-15}}</ref> As it had been suggested that deficits in hippocampal [[neurogenesis]] might underlie depression,<ref name=pmid12946878>{{cite journal |author=Kempermann G, Kronenberg G |title=Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression |journal=[[Biological Psychiatry]] |volume=54 |issue=5 |pages=499–503 |year=2003 |month=September |pmid=12946878 |doi= 10.1016/S0006-3223(03)00319-6|url=http://linkinghub.elsevier.com/retrieve/pii/S0006322303003196 |accessdate=2009-08-15}}</ref> Crusio and collaborators undertook a series of experiments investigating changes in behavior and neurogenesis in mice that had undergone UCMS. They showed dramatic changes in levels of [[aggression]],<ref name=pmid14574128>{{cite journal |author=Mineur YS, Prasol DJ, Belzung C, Crusio WE |title=Agonistic behavior and unpredictable chronic mild stress in mice |journal=[[Behavior Genetics (journal)|Behavior Genetics]] |volume=33 |issue=5 |pages=513–519 |year=2003 |month=September |pmid=14574128 |doi= 10.1023/A:1025770616068|url=http://www.kluweronline.com/art.pdf?issn=0001-8244&volume=33&page=513 |accessdate=2009-08-16}}</ref> [[anxiety]],<ref name=pmid17023061>{{cite journal |author=Mineur YS, Belzung C, Crusio WE |title=Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice |journal=[[Behavioural Brain Research]] |volume=175 |issue=1 |pages=43–50 |year=2006 |month=November |pmid=17023061 |doi=10.1016/j.bbr.2006.07.029 |url= }}</ref> depressive-like behaviors,<ref name=pmid17023061/> and learning,<ref name=pmid17981399>{{cite journal |author=Mineur YS, Belzung C, Crusio WE |title=Functional implications of decreases in neurogenesis following chronic mild stress in mice |journal=[[Neuroscience (journal)|Neuroscience]] |volume=150 |issue=2 |pages=251–259 |year=2007 |month=December |pmid=17981399 |doi=10.1016/j.neuroscience.2007.09.045 |url= }}</ref> with a concomitant drop in neurogenesis.<ref name=pmid17981399/> However, the results were strain- and sex-specific and there did not appear to be a clear-cut correlation between the different changes, so that they finally concluded that although their data do not disprove the idea that deficits in hippocampal neurogenesis solely underlie the behavioral impairments observed in human psychiatric disorders such as depression, they do not provide support for this hypothesis either.<ref name=pmid17981399/>
When mice are exposed to unpredictable [[Chronic (medicine)|chronic]] mild [[chronic stress|stress]] (UCMS), they start exhibiting symptoms reminiscent of [[major depressive disorder]] in humans.<ref name=pmid9452163>{{cite journal |author=Willner P |title=Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation |journal=[[Psychopharmacology (journal)|Psychopharmacology]] |volume=134 |issue=4 |pages=319–329 |date=December 1997 |pmid=9452163 |doi=10.1007/s002130050456 |s2cid=40941720 |url=http://link.springer.de/link/service/journals/00213/bibs/7134004/71340319.htm |access-date=2009-08-15 |archive-date=30 April 1999 |archive-url=https://web.archive.org/web/19990430040840/http://link.springer.de/link/service/journals/00213/bibs/7134004/71340319.htm |url-status=live }}</ref> As it had been suggested that deficits in hippocampal [[neurogenesis]] might underlie depression,<ref name=pmid12946878>{{cite journal |title=Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression |journal=[[Biological Psychiatry]] |volume=54 |issue=5 |pages=499–503 |date=September 2003 |pmid=12946878 |doi= 10.1016/S0006-3223(03)00319-6|last1=Kempermann |first1=G |last2=Kronenberg |first2=G |s2cid=26823096 }}</ref> Crusio and collaborators undertook a series of experiments investigating changes in behavior and neurogenesis in mice that had undergone UCMS. They showed dramatic changes in levels of [[aggression]],<ref name=pmid14574128>{{cite journal |title=Agonistic behavior and unpredictable chronic mild stress in mice |journal=[[Behavior Genetics (journal)|Behavior Genetics]] |volume=33 |issue=5 |pages=513–519 |date=September 2003 |pmid=14574128 |doi=10.1023/A:1025770616068 |url=http://www.kluweronline.com/art.pdf?issn=0001-8244&volume=33&page=513 |access-date=2009-08-16 |last1=Mineur |first1=Y. S. |last2=Prasol |first2=D. J. |last3=Belzung |first3=C |last4=Crusio |first4=W. E. |s2cid=20402648 }}{{Dead link|date=October 2021 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> [[anxiety]],<ref name=pmid17023061>{{cite journal |title=Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice |journal=[[Behavioural Brain Research]] |volume=175 |issue=1 |pages=43–50 |date=November 2006 |pmid=17023061 |doi=10.1016/j.bbr.2006.07.029 |last1=Mineur |first1=Y. S. |last2=Belzung |first2=C |last3=Crusio |first3=W. E. |s2cid=28014881 |doi-access=free }}</ref><ref>{{cite book | url=https://books.google.com/books?id=a2DVctEczBMC&pg=PT16 | title=Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience | publisher=Academic Press | author=Wahlsten, Douglas | year=2010 | pages=166 | isbn=9780123756756 | access-date=6 February 2015 | archive-date=3 June 2016 | archive-url=https://web.archive.org/web/20160603191737/https://books.google.com/books?id=a2DVctEczBMC&pg=PT16 | url-status=live }}</ref> depressive-like behaviors,<ref name=pmid17023061/> and learning,<ref name=pmid17981399>{{cite journal |title=Functional implications of decreases in neurogenesis following chronic mild stress in mice |journal=[[Neuroscience (journal)|Neuroscience]] |volume=150 |issue=2 |pages=251–259 |date=December 2007 |pmid=17981399 |doi=10.1016/j.neuroscience.2007.09.045 |last1=Mineur |first1=Y. S. |last2=Belzung |first2=C |last3=Crusio |first3=W. E. |s2cid=25560162 }}</ref> with a concomitant drop in neurogenesis.<ref name=pmid17981399/> However, the results were strain- and sex-specific and there did not appear to be a clear-cut correlation between the different changes, so that they finally concluded that although their data do not disprove the idea that deficits in hippocampal neurogenesis solely underlie the behavioral impairments observed in human psychiatric disorders such as depression, they do not provide support for this hypothesis either.<ref name=pmid17981399/>


=== Mouse model of autism ===
=== Mouse model of autism ===
More recently, Crusio investigates the possibility that ''[[FMR1|Fmr1]]'' [[knockout mouse|knockout mice]] might perhaps be used as a [[animal model|model]] for [[autism]]. This idea is based on the fact that patients suffering from the [[Fragile X syndrome]], caused by a deficiency of the ''FMR1'' gene often show autistic [[symptom]]s. A good mouse model for the Fragile X syndrome is available in the form of mice in which the ''Fmr1'' gene (the mouse [[homology (biology)|homologue]] of the human ''FMR1'' gene) has been invalidated.<ref name=pmid8033209>{{cite journal |author=The Dutch-Belgian Fragile X Consortium |title=''Fmr1'' knockout mice: a model to study fragile X mental retardation |journal=[[Cell (journal)|Cell]] |volume=78 |issue=1 |pages=23–33 |year=1994 |month=July |pmid=8033209 |doi= 10.1016/0092-8674(94)90569-X|url=http://linkinghub.elsevier.com/retrieve/pii/0092-8674(94)90569-X |accessdate=2009-08-15}}</ref> A review of the findings obtained with these mice in many different laboratories did indeed indicate that these animals display autistic-like symptoms,<ref name=pmid16998604>{{cite journal |author=Bernardet M, Crusio WE |title=Fmr1 KO mice as a possible model of autistic features |journal=The Scientific World Journal |volume=6 |issue= |pages=1164–1176 |year=2006 |pmid=16998604 |doi=10.1100/tsw.2006.220 |url= }}</ref> especially changes in [[social behavior]], a key symptom of autism.<ref name=pmid1634365>{{cite journal |author=Mineur YS, Huynh LX, Crusio WE |title=Social behavior deficits in the ''Fmr1'' mutant mouse |journal=[[Behavioural Brain Research]] |volume=168 |issue=1 |pages=172–175 |year=2006 |month=March |pmid=16343653 |doi=10.1016/j.bbr.2005.11.004 |url= }}</ref><ref name=pmid16176388>{{cite journal |author=Spencer CM, Alekseyenko O, Serysheva E, Yuva-Paylor LA, Paylor R |title=Altered anxiety-related and social behaviors in the ''Fmr1'' knockout mouse model of fragile X syndrome |journal=[[Genes, Brain and Behavior]] |volume=4 |issue=7 |pages=420–430 |year=2005 |month=October |pmid=16176388 |doi=10.1111/j.1601-183X.2005.00123.x |url= }}</ref>
More recently, Crusio has been investigating the possibility that ''[[FMR1|Fmr1]]'' [[knockout mouse|knockout mice]] might perhaps be used as a [[animal model|model]] for [[autism]]. This idea is based on the fact that patients suffering from the [[Fragile X syndrome]], caused by a deficiency of the ''FMR1'' gene often show autistic [[symptom]]s. A good mouse model for the Fragile X syndrome is available in the form of mice in which the ''Fmr1'' gene (the mouse [[homology (biology)|homologue]] of the human ''FMR1'' gene) has been invalidated.<ref name=pmid8033209>{{cite journal |author=The Dutch-Belgian Fragile X Consortium |title=''Fmr1'' knockout mice: a model to study fragile X mental retardation |journal=[[Cell (journal)|Cell]] |volume=78 |issue=1 |pages=23–33 |date=July 1994 |pmid=8033209 |doi= 10.1016/0092-8674(94)90569-X|s2cid=29674883 }}</ref> A review of the findings obtained with these mice in many different laboratories did indeed indicate that these animals display autistic-like symptoms,<ref name=pmid16998604>{{cite journal |title=Fmr1 KO mice as a possible model of autistic features |journal=The Scientific World Journal |volume=6 |pages=1164–1176 |year=2006 |pmid=16998604 |doi=10.1100/tsw.2006.220 |last1=Bernardet |first1=M |last2=Crusio |first2=W. E. |pmc=5917219 |doi-access=free }}</ref> especially changes in [[social behavior]], a key symptom of autism.<ref name=pmid1634365>{{cite journal |title=Social behavior deficits in the ''Fmr1'' mutant mouse |journal=[[Behavioural Brain Research]] |volume=168 |issue=1 |pages=172–175 |date=March 2006 |pmid=16343653 |doi=10.1016/j.bbr.2005.11.004 |last1=Mineur |first1=Y. S. |last2=Huynh |first2=L. X. |last3=Crusio |first3=W. E. |s2cid=45731129 }}</ref><ref name=pmid16176388>{{cite journal |title=Altered anxiety-related and social behaviors in the ''Fmr1'' knockout mouse model of fragile X syndrome |journal=[[Genes, Brain and Behavior]] |volume=4 |issue=7 |pages=420–430 |date=October 2005 |pmid=16176388 |doi=10.1111/j.1601-183X.2005.00123.x |last1=Spencer |first1=C. M. |last2=Alekseyenko |first2=O |last3=Serysheva |first3=E |last4=Yuva-Paylor |first4=L. A. |last5=Paylor |first5=R |s2cid=9094269 |doi-access=free }}</ref>


== Editorial activities ==
== Editorial activities ==
Crusio is the founding [[editor-in-chief]] of ''[[Genes, Brain and Behavior]]'',<ref name="THE">{{cite journal |author=Pagel, Mark |date=7 May 2004 |title=The order in a billion sequences |url=http://www.timeshighereducation.co.uk/story.asp?storyCode=188536&sectioncode=26 |journal=[[Times Higher Education]] |accessdate=2010-07-09}}</ref> which started in 2002 and currently has an [[impact factor]] of 4.061, ranking it 63rd out of 237 listed journals in the [[Neuroscience]]s category and 6th out of 48 listed journals in the [[Behavioural sciences|Behavioral Sciences]] category.<ref name=WoS>{{cite web |url = http://isiwebofknowledge.com |title = Web of Science |year = 2010 |accessdate = 2012-02-16}}</ref> The standards for the publication of mouse mutant studies that he and his co-editors developed for this journal<ref>{{cite journal |author=Crusio WE, Goldowitz D, Holmes A, Wolfer D |title=Standards for the publication of mouse mutant studies |journal=Genes, Brain and Behavior |volume=8 |issue=1 |pages=1–4 |year=2009 |month=February |pmid=18778401 |doi=10.1111/j.1601-183X.2008.00438.x}}</ref> are gradually being accepted in the field.<ref name=EJN>{{cite web |url=http://www3.interscience.wiley.com/journal/118542297/home/ForAuthors.html |title=Instructions for authors |work=[[European Journal of Neuroscience]] |accessdate=2009-08-30}}</ref><ref name=NN09>{{cite journal|title=Troublesome variability in mouse studies|journal=[[Nature Neuroscience]]|date=September 2009|first=|last=Editorial|coauthors=|volume=12|issue=9|page=1075|pmid=19710643 |url=http://www.nature.com/neuro/journal/v12/n9/abs/nn0909-1075.html|accessdate=2009-08-30|doi=10.1038/nn0909-1075}}</ref> He is an academic editor of ''[[PLoS ONE]]'' and served as associate editor of ''[[Behavioral and Brain Sciences]]'' (1991–2008) and ''[[The Scientific World Journal]]'' (2002-2011). Crusio serves or has served on the [[editorial board]]s of ''[[Behavioral and Brain Functions]], [[Behavior Genetics (journal)|Behavior Genetics]]'' (1991–1995), ''[[Behavioural Brain Research]]'' (1997–2007), ''[[BMC Neuroscience]]'', ''[[BMC Research Notes]], [[Frontiers in Neuroscience|Frontiers in Behavioral Neuroscience]], [[Journal of Visualized Experiments]], [[Molecular Brain]], [[Neurogenetics (journal)|Neurogenetics]]'' (1998–2006), and ''[[Physiology and Behavior]]''. He edited special issues for the journals ''Behavior Genetics'',<ref name=siBG>{{cite journal |editor=Crusio WE |title=Special issue: The neurobehavioral genetics of aggression |journal=Behavior Genetics |volume=26 |issue=5 |pages=459–504 |year=1996 |month=September|doi= 10.1007/BF02359749|url=http://www.springerlink.com/content/qh123t688p47/?p=19b76978284d46ad9ba5698f4eb3c769&pi=77 |accessdate=2009-08-14 |author=Crusio, Wim E.}}</ref> ''Behavioural Brain Research'',<ref name=siBBR>{{cite journal |editor=Crusio WE |title=Special issue: The genetic dissection of brain-behaviour relationships: An introduction to neurobehavioural genetics |journal=Behavioural Brain Research |volume=95 |issue=1 |pages=1–142 |year=1998 |month=September|doi= 10.1016/S0166-4328(97)00203-9|url=http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%234840%231998%23999049998%2317924%23FLA%23&_cdi=4840&_pubType=J&_auth=y&_acct=C000025358&_version=1&_urlVersion=0&_userid=513493&md5=094a14a497927f37dfc984b8df87c6f0 |accessdate=2009-08-14}}</ref> ''Physiology and Behavior'' (with [[Robert Gerlai]]),<ref name=siPNB>{{cite journal |editor=Gerlai RT, Crusio WE |title=Special issue: Bridging the gap from gene to behavior: Recombinant DNA techniques merge with behavioral neurobiology |journal=Physiology and Behavior |volume=73 |issue=5 |pages=671–886 |year=2001 |month=August|doi= 10.1016/S0031-9384(01)00583-2|url=http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%234868%232001%23999269994%23263983%23FLA%23&_cdi=4868&_pubType=J&_auth=y&_acct=C000025358&_version=1&_urlVersion=0&_userid=513493&md5=036dbb55c5c22b306db757cbb81fc27f |accessdate=2009-08-14}}</ref> ''[[Hippocampus (journal)|Hippocampus]]'' (with [[Aryeh Routtenberg]]),<ref name=siHIP>{{cite journal |editor=Routtenberg A, Crusio WE |title=Special Issue: Gene Targeting and Hippocampal Function |journal=Hippocampus |volume=12 |issue=1 |pages=1–108 |year=2001 |month=February|doi= |url=http://www3.interscience.wiley.com/journal/90010627/issue |accessdate=2009-08-14}}</ref> and ''[[Brain Research Bulletin]]'' (with Catherine Belzung and Robert Gerlai).<ref name=siBRB>{{cite journal |editor=Belzung C, Crusio WE, Gerlai RT |title=Special issue: Behavioral neurogenetics, the genetic dissection of brain and behavior |journal=Brain Research Bulletin |volume=57 |issue=1 |pages=1–131 |year=2002 |month=January|doi= 10.1016/S0361-9230(01)00629-3|url=http://www3.interscience.wiley.com/journal/90010627/issue |accessdate=2009-08-14 |pmid=11827730}}</ref> Together with Robert Gerlai he also edited a [[handbook]] on [[molecular genetics|molecular genetic]] techniques for [[behavioral neuroscience]].<ref name=handbook>{{cite book |author= Crusio, WE and Gerlai, RT |title=Handbook of Molecular-Genetic Techniques for Brain and Behavior Research |publisher=[[Elsevier]] |location=[[Amsterdam]] |year=1999 |pages=xxvii+965 |isbn=0-444-50239-4 |oclc= }}</ref><ref name=worldcat>{{cite web |url=http://www.worldcat.org/identities/lccn-n99-46580 |title=Crusio, W.E. <nowiki>[WorldCat Identities]</nowiki> |work= |accessdate=2009-08-11}}</ref><ref>{{cite journal |doi=10.1016/S0166-2236(00)01670-2 |title=A tool for synthesis |year=2001 |last1=Skoulakis |first1=Efthimios M.C |journal=Trends in Neurosciences |volume=24 |issue=2 |pages=127}} Reprinted in: {{cite journal |journal=Trends in Molecular Medicine |year=2001 |volume=7 |issue=3 |pages=139 |doi=10.1016/S1471-4914(01)01956-6}}</ref> Currently, he is editing the ''Cambridge Handbooks in Behavioral Genetics'', a series of handbooks published by [[Cambridge University Press]],<ref>{{cite web |url=http://cambridge.org//knowledge/series/series_display/item6661364 |title=Series - Cambridge Handbooks in Behavioral Genetics |format= |publisher=Cambridge University Press |accessdate=2012-11-25}}</ref> of which the first volume, ''Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes'', appeared in 2013.<ref>{{cite book |url=http://www.cambridge.org/gb/knowledge/isbn/item7059590/?site_locale=en_GB |title=Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes |editor1-last=Crusio| editor1-first=Wim E. |editor2-last=Sluyter |editor2-first=Frans |editor3-last=Gerlai |editor3-first=Robert T. |editor3-link=Robert Gerlai |editor4-last=Pietropaolo |editor4-first=Susanna |publisher=Cambridge University Press |location=Cambridge, United Kingdom |accessdate=2013-05-03 |series=Cambridge Handbooks in Behavioral Genetics |year=2013 |month=April |isbn=978-1-107-03481-5 |displayeditors=4}}</ref>
Crusio is the founding [[editor-in-chief]] of ''[[Genes, Brain and Behavior]]'', which he edited from 2001 to 2011.<ref name="THE">{{cite journal |author=Pagel, Mark |date=7 May 2004 |title=The order in a billion sequences |url=http://www.timeshighereducation.co.uk/story.asp?storyCode=188536&sectioncode=26 |journal=[[Times Higher Education]] |access-date=2010-07-09 |archive-date=3 April 2012 |archive-url=https://web.archive.org/web/20120403011355/http://www.timeshighereducation.co.uk/story.asp?storyCode=188536&sectioncode=26 |url-status=live }}</ref> The standards for the publication of mouse mutant studies that he and his co-editors developed for this journal<ref>{{cite journal |title=Standards for the publication of mouse mutant studies |journal=Genes, Brain and Behavior |volume=8 |issue=1 |pages=1–4 |date=February 2009 |pmid=18778401 |doi=10.1111/j.1601-183X.2008.00438.x|last1=Crusio |first1=W. E. |last2=Goldowitz |first2=D |last3=Holmes |first3=A |last4=Wolfer |first4=D |s2cid=205853147 |doi-access=free }}</ref> are gradually being accepted in the field.<ref name=EJN>{{cite journal |title=Author Guidelines |journal=[[European Journal of Neuroscience]] |doi=10.1111/(ISSN)1460-9568|citeseerx = 10.1.1.721.6506}}</ref><ref name=NN09>{{cite journal|title=Troublesome variability in mouse studies|journal=[[Nature Neuroscience]]|date=September 2009|last=Editorial|volume=12|issue=9|page=1075|pmid=19710643 |doi=10.1038/nn0909-1075|doi-access=free}}</ref><ref>{{cite web |title=Preparing your manuscript – Research – Criteria |url=https://behavioralandbrainfunctions.biomedcentral.com/submission-guidelines/preparing-your-manuscript/research |website=Behavioral and Brain Functions |publisher=BioMed Central |access-date=2020-05-05 |archive-date=3 June 2021 |archive-url=https://web.archive.org/web/20210603221106/https://behavioralandbrainfunctions.biomedcentral.com/submission-guidelines/preparing-your-manuscript/research |url-status=live }}</ref> Since 2017, Crusio is the editor-in-chief of ''[[Behavioral and Brain Functions]]''<ref>{{cite web |url=https://behavioralandbrainfunctions.biomedcentral.com/about/editorial-board |title=Editorial Board |website=Behavioral and Brain Functions |publisher=[[BioMed Central]] |access-date=2017-08-25 |archive-date=19 September 2020 |archive-url=https://web.archive.org/web/20200919091620/https://behavioralandbrainfunctions.biomedcentral.com/about/editorial-board |url-status=live }}</ref> and since 2019 co-editor of ''[[Advances in Experimental Medicine and Biology]]''.<ref>{{cite web |title=Advances in Experimental Medicine and Biology |url=https://www.springer.com/series/5584 |publisher=[[Springer Nature]] |access-date=2019-10-30 |archive-date=30 November 2019 |archive-url=https://web.archive.org/web/20191130033416/https://www.springer.com/series/5584 |url-status=live }}</ref> He is also an academic editor of ''[[PLoS ONE]]'' and served as associate editor of ''[[Behavioral and Brain Sciences]]'' (1991–2008) and ''[[The Scientific World Journal]]'' (2002-2011). Crusio serves or has served on the [[editorial board]]s of ''Behavioral and Brain Functions, [[Behavior Genetics (journal)|Behavior Genetics]]'' (1991–1995), ''[[Behavioural Brain Research]]'' (1997–2007), ''[[BMC Neuroscience]]'', ''[[BMC Research Notes]], [[Frontiers in Neuroscience|Frontiers in Behavioral Neuroscience]], [[Journal of Visualized Experiments]], [[Molecular Brain]] ''(2012-2017)'', [[Neurogenetics (journal)|Neurogenetics]]'' (1998–2006), ''[[Physiology and Behavior]]'', and ''[[Current Opinion in Behavioral Sciences]]''. He edited special issues for the journals ''Behavior Genetics'',<ref name=siBG>{{cite journal |editor=Crusio WE |title=Special issue: The neurobehavioral genetics of aggression |journal=Behavior Genetics |volume=26 |issue=5 |pages=459–504 |date=September 1996 |doi=10.1007/BF02359749 |pmid=8917943 |url=https://link.springer.com/journal/10519/26/5/page/1 |access-date=2009-08-14 |author=Crusio, Wim E. |s2cid=31579336 |archive-date=25 August 2017 |archive-url=https://web.archive.org/web/20170825020013/https://link.springer.com/journal/10519/26/5/page/1 |url-status=live }}</ref> ''Behavioural Brain Research'',<ref name=siBBR>{{cite journal |editor=Crusio WE |title=Special issue: The genetic dissection of brain-behaviour relationships: An introduction to neurobehavioural genetics |journal=Behavioural Brain Research |volume=95 |issue=1 |pages=1–142 |date=September 1998 |doi=10.1016/S0166-4328(97)00203-9 |s2cid=208791454 |url=http://www.sciencedirect.com/science/journal/01664328/95/1 |access-date=2009-08-14 |archive-date=13 March 2013 |archive-url=https://web.archive.org/web/20130313202627/http://www.sciencedirect.com/science/journal/01664328/95/1 |url-status=live }}</ref> ''Physiology and Behavior'' (with [[Robert Gerlai]]),<ref name=siPNB>{{cite journal |veditors=Gerlai RT, Crusio WE |title=Special issue: Bridging the gap from gene to behavior: Recombinant DNA techniques merge with behavioral neurobiology |journal=Physiology and Behavior |volume=73 |issue=5 |pages=671–886 |date=August 2001 |doi=10.1016/S0031-9384(01)00583-2 |url=http://www.sciencedirect.com/science/journal/00319384/73/5 |access-date=2009-08-14 |last1=Gerlai |first1=Robert T. |s2cid=54311109 |archive-date=24 September 2015 |archive-url=https://web.archive.org/web/20150924193457/http://www.sciencedirect.com/science/journal/00319384/73/5 |url-status=live }}</ref> ''[[Hippocampus (journal)|Hippocampus]]'' (with [[Aryeh Routtenberg]]),<ref name=siHIP>{{cite journal |veditors=Routtenberg A, Crusio WE |title=Special Issue: Gene Targeting and Hippocampal Function |journal=Hippocampus |volume=12 |issue=1 |pages=2–3 |date=February 2001 |doi=10.1002/hipo.10001 |pmid=11918284 |url=http://onlinelibrary.wiley.com/doi/10.1002/hipo.v12:1/issuetoc |access-date=2009-08-14 |last1=Crusio |first1=Wim E. |last2=Routtenberg |first2=Aryeh |s2cid=37535269 |archive-date=22 October 2012 |archive-url=https://web.archive.org/web/20121022005843/http://onlinelibrary.wiley.com/doi/10.1002/hipo.v12:1/issuetoc |url-status=live }}</ref> and ''[[Brain Research Bulletin]]'' (with Catherine Belzung and Robert Gerlai).<ref name=siBRB>{{cite journal |veditors=Belzung C, Crusio WE, Gerlai RT |title=Special issue: Behavioral neurogenetics, the genetic dissection of brain and behavior |journal=Brain Research Bulletin |volume=57 |issue=1 |pages=1–131 |date=January 2002 |doi=10.1016/S0361-9230(01)00629-3 |url=http://www.sciencedirect.com/science/journal/03619230/57/1 |access-date=2009-08-14 |pmid=11827730 |last1=Belzung |first1=Catherine |last2=Crusio |first2=Wim E. |last3=Gerlai |first3=Robert T. |s2cid=9742148 |archive-date=24 September 2015 |archive-url=https://web.archive.org/web/20150924194141/http://www.sciencedirect.com/science/journal/03619230/57/1 |url-status=live }}</ref> Together with Robert Gerlai he also edited a [[handbook]] on [[molecular genetics|molecular genetic]] techniques for [[behavioral neuroscience]].<ref name=handbook>{{cite book |last1=Crusio |first1=WE |last2=Gerlai |first2=RT |title=Handbook of Molecular-Genetic Techniques for Brain and Behavior Research |publisher=[[Elsevier]] |location=[[Amsterdam]] |year=1999 |pages=xxvii+965 |isbn=978-0-444-50239-1 }}</ref><ref name=worldcat>{{cite web |url=http://www.worldcat.org/identities/lccn-n99-46580 |title=Crusio, W.E. <nowiki>[WorldCat Identities]</nowiki> |access-date=2009-08-11 |archive-date=17 December 2013 |archive-url=https://web.archive.org/web/20131217221811/http://www.worldcat.org/identities/lccn-n99-46580 |url-status=live }}</ref><ref>{{cite journal |doi=10.1016/S0166-2236(00)01670-2 |title=A tool for synthesis |year=2001 |last1=Skoulakis |first1=Efthimios M.C. |journal=Trends in Neurosciences |volume=24 |issue=2 |pages=127|s2cid=53185722 }} Reprinted in: {{cite journal |journal=Trends in Molecular Medicine |year=2001 |volume=7 |issue=3 |pages=139 |doi=10.1016/S1471-4914(01)01956-6|title=A tool for synthesis |last1=Skoulakis |first1=Efthimios M.C }}</ref> Currently, he is editing the ''Cambridge Handbooks in Behavioral Genetics'', a series of handbooks published by [[Cambridge University Press]],<ref>{{cite web |url=http://cambridge.org//knowledge/series/series_display/item6661364 |title=Series – Cambridge Handbooks in Behavioral Genetics |publisher=Cambridge University Press |access-date=2012-11-25 |archive-date=25 September 2015 |archive-url=https://web.archive.org/web/20150925120113/http://www.cambridge.org//knowledge/series/series_display/item6661364 |url-status=live }}</ref> of which the first volume, ''Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes'', appeared in 2013.<ref>{{cite journal |title=Book review: Behavioral Genetics of the Mouse |year=2014 |last1=Mandillo |first1=Silvia |journal=Genes, Brain and Behavior |volume=13 |issue=5 |pages=517 |doi=10.1111/gbb.12125|doi-access=free }}</ref><ref>{{cite journal |doi=10.4415/ANN_14_04_14 |last1=Michetti |first1=Caterina |title=BEHAVIORAL GENETICS OF THE MOUSE. Genetics of Behavioral Phenotypes. Volume 1 |journal=[[Annali dell'Istituto Superiore di Sanità]] |year=2014 |volume=50 |issue=4 |pages=378–379 |url=http://www.scielosp.org/pdf/aiss/v50n4/14.pdf |access-date=31 July 2016 |archive-date=8 August 2016 |archive-url=https://web.archive.org/web/20160808011519/http://www.scielosp.org/pdf/aiss/v50n4/14.pdf |url-status=live }}</ref> Since then, two more volumes have appeared.<ref>{{cite web |url=http://www.cambridge.org/academic/subjects/life-sciences/genetics/series/cambridge-handbooks-behavioral-genetics |title=Cambridge Handbooks in Behavioral Genetics |publisher=Cambridge University Press |location=Cambridge, United Kingdom |access-date=2015-10-29 |archive-date=2 October 2021 |archive-url=https://web.archive.org/web/20211002112054/https://www.cambridge.org/us/academic/subjects/life-sciences/genetics/series/cambridge-handbooks-behavioral-genetics |url-status=live }}</ref>


== Community service ==
== Community service ==
In 1996, Crusio was one of two co-founders of the [[International Behavioural and Neural Genetics Society]],<ref name=History>{{cite web |url=http://www.ibangs.org/mc/page.do?sitePageId=83923&orgId=ibngs |title=IBANGS History |work=IBANGS Homepage |accessdate=2009-04-01}}</ref> for which he served as member-at-large of the executive committee, [[treasurer]], and [[president]] (1998–2001).<ref>{{cite web|url=http://www.ibangs.org/index.php?option=com_content&view=article&id=46|title=Past Officers and Executive Committee Members|accessdate=9 March 2012}}</ref> In 2011 he received from this society the "Distinguished Service Award",<ref>{{cite web |url=http://www.ibangs.org/mc/page.do?sitePageId=83207&orgId=ibngs |title=IBANGS Awards |format= |work=IBANGS Homepage |accessdate=2011-11-25}}</ref> which is given for exceptional contributions to the field of behavioral neurogenetics.<ref>{{cite web |url=http://www.ibangs.org/mc/page.do?sitePageId=93495&orgId=ibngs |title=Call for 2011 IBANGS award nominations |format= |work=IBANGS Homepage |accessdate=2011-11-25}}</ref> Crusio also served on the executive committees of the [[Behavior Genetics Association]] (from which he resigned in protest to [[Glayde Whitney#Political controversies|Glayde Whitney's 1995 presidential address]]),<ref>{{cite book |editor1-first=Yong-Kyu |editor1-last=Kim |last1=Loehlin |first1=John |authorlink2=John Loehlin | title=Handbook of Behavior Genetics |chapter=History of behavior genetics |publisher=Springer |location=Berlin |isbn=978-0-387-76726-0 |pages=3–11 |url=http://books.google.com/?id=T3P_SLtfIN0C&lpg=PA11&dq=crusio%20%22glayde%20whitney%22&pg=PA11#v=onepage&q=crusio%20%22glayde%20whitney%22 |date=2009-04-01}}</ref> the [[European Brain and Behaviour Society]],<ref name=EBBS>{{cite web |url=http://www.ebbs-science.org/cms/general/committee-members.html |title=Past committee members|work= |accessdate=2009-08-11}}</ref> and the [[International Behavioral Neuroscience Society]] (IBNS),<ref name=IBNS>{{cite web |url=http://www.ibnshomepage.org/history.htm |title=IBNS History of Officers |work= |accessdate=2009-08-11}}</ref> and has been a President of the Dutch Behavior Genetics Contact Group.<ref>{{cite journal |title=Obituary Sjeng Kerbusch (1947-1991) |journal=[[Behavior Genetics (journal)|Behavior Genetics]] |year=1991 |first=W.E. |last=Crusio |volume=21 |issue=5 |pages=431–432 |doi=10.1007/BF01066721 }}</ref> He has been a member of several program committees for scientific meetings, most notably the 8th and 10th<ref name=Xth>{{cite web |url=http://www.wcpg2002.be/ |title=Xth World Congress on Psychiatric Genetics - Committees |work= |accessdate=2010-07-09 |archiveurl = http://web.archive.org/web/20020930114155/http://www.wcpg2002.be/ |archivedate = 30 September 2002}}</ref> [[International Society for Psychiatric Genetics|World Congresses of Psychiatric Genetics]] and the 2008, 2009 (co-chair), 2010 (chair), and 2011 (chair) Annual Meetings of the IBNS.<ref name=IBNScommittees>{{cite web |url=http://www.ibnshomepage.org/committees.htm |title=IBNS Committees/Mission Statements |work= |accessdate=2009-08-11}}</ref>
In 1996, Crusio was one of two co-founders of the [[International Behavioural and Neural Genetics Society]],<ref name=History>{{cite web |url=http://www.ibangs.org/mc/page.do?sitePageId=83923&orgId=ibngs |title=IBANGS History |work=IBANGS Homepage |access-date=2009-04-01 |archive-date=26 July 2011 |archive-url=https://web.archive.org/web/20110726164433/http://www.ibangs.org/mc/page.do?sitePageId=83923&orgId=ibngs |url-status=dead }}</ref> for which he served as member-at-large of the executive committee, [[treasurer]], and [[president (corporate title)|president]] (1998–2001).<ref>{{cite web|url=http://www.ibangs.org/index.php?option=com_content&view=article&id=46|title=Past Officers and Executive Committee Members|access-date=9 March 2012|archive-date=9 March 2012|archive-url=https://web.archive.org/web/20120309151802/http://www.ibangs.org/index.php?option=com_content&view=article&id=46|url-status=live}}</ref> In 2011 he received from this society the "Distinguished Service Award",<ref>{{cite web |url=http://www.ibangs.org/mc/page.do?sitePageId=83207&orgId=ibngs |title=IBANGS Awards |work=IBANGS Homepage |access-date=2011-11-25 |archive-date=1 October 2011 |archive-url=https://web.archive.org/web/20111001232515/http://www.ibangs.org/mc/page.do?sitePageId=83207 |url-status=dead }}</ref> which is given for exceptional contributions to the field of behavioral neurogenetics.<ref>{{cite web |url=http://www.ibangs.org/mc/page.do?sitePageId=93495&orgId=ibngs |title=Call for 2011 IBANGS award nominations |work=IBANGS Homepage |access-date=2011-11-25 |archive-date=1 October 2011 |archive-url=https://web.archive.org/web/20111001234436/http://www.ibangs.org/mc/page.do?sitePageId=93495 |url-status=dead }}</ref> Crusio also served on the executive committees of the [[Behavior Genetics Association]] (from which he resigned in protest to [[Glayde Whitney#Political controversies|Glayde Whitney's 1995 presidential address]]),<ref>{{cite book |editor1-first=Yong-Kyu |editor1-last=Kim |last1=Loehlin |first1=John |title=Handbook of Behavior Genetics |chapter=History of behavior genetics |publisher=Springer |location=Berlin |isbn=978-0-387-76726-0 |pages=3–11 |chapter-url=https://books.google.com/books?id=T3P_SLtfIN0C&q=crusio+%22glayde+whitney%22&pg=PA11 |date=2009-04-01 |access-date=17 December 2020 |archive-date=2 October 2021 |archive-url=https://web.archive.org/web/20211002112040/https://books.google.com/books?id=T3P_SLtfIN0C&q=crusio+%22glayde+whitney%22&pg=PA11 |url-status=live }}</ref><ref>{{cite book | date=2014 | first1=Aaron | isbn=978-0-226-05831-3 | last1=Panofsky | title=Misbehaving Science. Controversy and the Development of Behavior Genetics | publisher=[[University of Chicago Press]] | location=Chicago | pages=3–4}}</ref> the [[European Brain and Behaviour Society]],<ref name=EBBS>{{cite web|url=http://www.ebbs-science.org/cms/general/committee-members.html|title=Past committee members|access-date=2009-08-11|archive-date=14 March 2012|archive-url=https://web.archive.org/web/20120314123152/http://www.ebbs-science.org/cms/general/committee-members.html|url-status=live}}</ref> and the [[International Behavioral Neuroscience Society]],<ref name=IBNS>{{cite web |url=http://www.ibnshomepage.org/history.htm |title=IBNS History of Officers |access-date=2009-08-11 |archive-date=21 November 2008 |archive-url=https://web.archive.org/web/20081121061052/http://www.ibnshomepage.org/history.htm |url-status=dead }}</ref> and has been a President of the Dutch Behavior Genetics Contact Group.<ref>{{cite journal |title=Obituary Sjeng Kerbusch (1947-1991) |journal=[[Behavior Genetics (journal)|Behavior Genetics]] |year=1991 |first=W.E. |last=Crusio |volume=21 |issue=5 |pages=431–432 |doi=10.1007/BF01066721 |s2cid=148069790 |doi-access=free }}</ref> He has been a member of several program committees for scientific meetings, most notably the 8th and 10th<ref name=Xth>{{cite web |url=http://www.wcpg2002.be/ |title=Xth World Congress on Psychiatric Genetics – Committees |access-date=2010-07-09 |archive-url = https://web.archive.org/web/20020930114155/http://www.wcpg2002.be/ |archive-date = 30 September 2002}}</ref> [[International Society of Psychiatric Genetics|World Congresses of Psychiatric Genetics]] and the 2008, 2009 (co-chair), 2010 (chair), and 2011 (chair) Annual Meetings of the IBNS.<ref name=IBNScommittees>{{cite web |url=http://www.ibnshomepage.org/committees.htm |title=IBNS Committees/Mission Statements |access-date=2009-08-11 |archive-date=4 May 2009 |archive-url=https://web.archive.org/web/20090504005059/http://www.ibnshomepage.org/committees.htm |url-status=dead }}</ref>


== Significant papers ==
== Significant papers ==
{{Scholia}}
According to the [[Web of Science]], Crusio's works have been cited over 3400 times and he has an [[h-index]] of 34.<ref name=ISI>{{cite web |url=http://www.researcherid.com/rid/A-7070-2008 |title=Wim Crusio A-7070-2008 |work=[[ResearcherID]] |accessdate=2013-10-17}}</ref> Some significant papers are:
According to [[Google Scholar]], Crusio's works have been cited over 10,000 times and he has an [[h-index]] of 46.<ref>{{cite web |title=Wim Crusio |url=https://scholar.google.com/citations?user=7qhmlzwAAAAJ&hl=en |website=[[Google Scholar]] |access-date=2022-05-16}}</ref> Some significant papers are:
⚫
* {{cite journal |author=Crusio WE, Genthner-Grimm G, Schwegler H |title=A quantitative-genetic analysis of hippocampal variation in the mouse |journal=[[Journal of Neurogenetics]] |volume=21 |issue=4; Special Retrospective Issue: ''The Origins of Neurogenetics'' |pages=197–208 |year=2007 |pmid=18161583 |doi=10.1080/01677060701715827 |url= }} Original publication: {{cite journal |journal=Journal of Neurogenetics |volume=3 |issue=4 |pages=203–214 |year=1986 |month=July |pmid=3746523 |doi= 10.3109/01677068609106850|url= |title=A Quantitative-Genetic Analysis of Hippocampal Variation in the Mouse |author=Crusio, W. E. |last2=Genthner-Grimm |first2=G |last3=Schwegler |first3=H}}

* {{cite journal |author=Crusio WE, Schwegler H, Lipp HP |title=Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution |journal=[[Brain Research]] |volume=425 |issue=1 |pages=182–185 |year=1987 |month=November |pmid=3427419 |doi=10.1016/0006-8993(87)90498-7 |url= }}
⚫
* {{cite journal |title=A quantitative-genetic analysis of hippocampal variation in the mouse |journal=[[Journal of Neurogenetics]] |volume=21 |issue=4; Special Retrospective Issue: ''The Origins of Neurogenetics'' |pages=197–208 |year=2007 |pmid=18161583 |doi=10.1080/01677060701715827 |last1=Crusio |first1=W. E. |last2=Genthner-Grimm |first2=G. |last3=Schwegler |first3=H.|s2cid=7334116 }} Original publication: {{cite journal |journal=Journal of Neurogenetics |volume=3 |issue=4 |pages=203–214 |date=July 1986 |pmid=3746523 |doi= 10.3109/01677068609106850|title=A quantitative-genetic analysis of hippocampal variation in the mouse |last1=Crusio |first1=W. E. |last2=Genthner-Grimm |first2=G. |last3=Schwegler |first3=H.}}
⚫
* {{cite journal |author=Crusio WE, Schwegler H, van Abeelen JH |title=Behavioral responses to novelty and structural variation of the hippocampus in mice. II. Multivariate genetic analysis |journal=[[Behavioural Brain Research]] |volume=32 |issue=1 |pages=81–88 |year=1989 |month=February |pmid=2930637 |doi=10.1016/S0166-4328(89)80075-0}}
*{{cite journal |author=Crusio WE |title=Genetic dissection of mouse exploratory behaviour |journal=[[Behavioural Brain Research]] |volume=125 |issue=1–2 |pages=127–132 |year=2001 |month=November |pmid=11682103 |doi= 10.1016/S0166-4328(01)00280-7|url= }}
* {{cite journal |title=Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution |journal=[[Brain Research]] |volume=425 |issue=1 |pages=182–185 |date=November 1987 |pmid=3427419 |doi=10.1016/0006-8993(87)90498-7 |last1=Crusio |first1=W. E. |last2=Schwegler |first2=H. |last3=Lipp |first3=H. P.|s2cid=39198617 }}
* {{cite journal |author=Crusio WE, Goldowitz D, Holmes A, Wolfer D |title=Standards for the publication of mouse mutant studies |journal=[[Genes, Brain and Behavior]] |volume=8 |issue=1 |pages=1–4 |year=2009 |month=February |pmid=18778401 |doi=10.1111/j.1601-183X.2008.00438.x}}
* {{cite journal |title=Behavioral responses to novelty and structural variation of the hippocampus in mice. II. Multivariate genetic analysis |journal=[[Behavioural Brain Research]] |volume=32 |issue=1 |pages=81–88 |date=February 1989 |pmid=2930637 |doi=10.1016/S0166-4328(89)80075-0|last1=Crusio |first1=W. E. |last2=Schwegler |first2=H. |last3=van Abeelen |first3=J. H. F.|s2cid=42291976 }}
⚫
*{{cite journal |author=Crusio W. E. |title=Genetic dissection of mouse exploratory behaviour |journal=[[Behavioural Brain Research]] |volume=125 |issue=1–2 |pages=127–132 |date=November 2001 |pmid=11682103 |doi= 10.1016/S0166-4328(01)00280-7|s2cid=28031277 }}
* {{cite journal |title=Standards for the publication of mouse mutant studies |journal=[[Genes, Brain and Behavior]] |volume=8 |issue=1 |pages=1–4 |date=February 2009 |pmid=18778401 |doi=10.1111/j.1601-183X.2008.00438.x|last1=Crusio |first1=W. E. |last2=Goldowitz |first2=D. |last3=Holmes |first3=A. |last4=Wolfer |first4=D.|s2cid=205853147 |doi-access=free }}


== References ==
== References ==
{{reflist|colwidth=30em}}
{{reflist}}


== External links ==
== External links ==
{{Scholia|author}}
* [http://www.mousebehavior.com/vitae_wec.htm Curriculum Vitae]
* {{cite web |url=http://www.incia.u-bordeaux1.fr/spip.php?article168 |title=Crusio Wim |publisher=The Aquitaine Institute for Cognitive and Integrative Neuroscience |work=Homepage |accessdate=2012-01-12}}
* {{cite web |url=http://www.incia.u-bordeaux1.fr/spip.php?article168 |title=Crusio Wim |publisher=The Aquitaine Institute for Cognitive and Integrative Neuroscience |work=Homepage |access-date=2012-01-12 |archive-date=21 October 2014 |archive-url=https://web.archive.org/web/20141021164838/http://www.incia.u-bordeaux1.fr/spip.php?article168 |url-status=dead }}
* {{cite web|url=http://scholar.google.com/citations?user=7qhmlzwAAAAJ |title=Wim Crusio - Google Scholar Citations |publisher=Google Scholar |date= |accessdate=2013-10-10}}
* {{cite web|url=https://scholar.google.com/citations?user=7qhmlzwAAAAJ |title=Wim Crusio – Google Scholar Citations |publisher=Google Scholar |access-date=2013-10-10}}


{{Authority control}}
{{Authority control}}


{{Persondata <!-- Metadata: see [[Wikipedia:Persondata]] -->
|NAME = Crusio, Wim
|ALTERNATIVE NAMES = Crusio, W. E.
|SHORT DESCRIPTION = Dutch behavioral and neural geneticist
|DATE OF BIRTH = 20 December 1954
|PLACE OF BIRTH = [[Bergen op Zoom]], The [[Netherlands]]
|DATE OF DEATH =
|PLACE OF DEATH =
}}
{{DEFAULTSORT:Crusio, Wim}}
{{DEFAULTSORT:Crusio, Wim}}
[[Category:1954 births]]
[[Category:1954 births]]
[[Category:Living people]]
[[Category:Living people]]
[[Category:Academic journal editors]]
[[Category:Scientific journal editors]]
[[Category:Behavior geneticists]]
[[Category:Behavior geneticists]]
[[Category:Dutch neuroscientists]]
[[Category:Dutch neuroscientists]]
[[Category:20th-century Dutch biologists]]
[[Category:21st-century Dutch biologists]]
[[Category:People from Bergen op Zoom]]
[[Category:People from Bergen op Zoom]]
[[Category:Radboud University Nijmegen alumni]]
[[Category:Radboud University Nijmegen alumni]]
[[Category:University of Massachusetts Medical School faculty]]
[[Category:UMass Chan Medical School faculty]]
[[Category:Botanists with author abbreviations]]
[[Category:Botanists with author abbreviations]]
[[Category:French National Centre for Scientific Research]]
[[Category:French National Centre for Scientific Research scientists]]
[[Category:20th-century biologists]]
[[Category:20th-century Dutch botanists]]
[[Category:Dutch botanists]]
[[Category:21st-century Dutch botanists]]
[[Category:21st-century biologists]]
[[Category:Founders of learned societies]]
[[Category:Ethologists]]
[[Category:Book editors]]
[[Category:Dutch expatriates in France]]
[[Category:Behavioral neuroscientists]]

Latest revision as of 13:22, 13 November 2024

Wim E. Crusio
Wilhelmus Elisabeth Crusio
Wim Crusio, August 2006
Born (1954-12-20) 20 December 1954 (age 70)
Bergen op Zoom, The Netherlands
CitizenshipDutch
Alma materRadboud University Nijmegen
Known forBehavioral neurogenetics of the hippocampus, mouse models of neuropsychiatric disorders
AwardsIBANGS Distinguished Service Award
Scientific career
Fieldsbehavioral and neural genetics, behavioral neuroscience
InstitutionsRadboud University Nijmegen, University of Heidelberg, French National Centre for Scientific Research (CNRS; Paris, Orleans, and Talence (Bordeaux)), University of Massachusetts Medical School
ThesisOlfaction and behavioral responses to novelty in mice: a quantitative-genetic analysis (1984)
Doctoral advisorHans van Abeelen
Other academic advisorsBram van Overbeeke,
Hendrik de Wit,
Victor Westhoff
Author abbrev. (botany)Crusio
Websitewimcrusio.com
Wikispecies has information related to Wim Crusio.

Wim E. Crusio (born Wilhelmus Elisabeth Crusio on 20 December 1954) is a Dutch behavioral neurogeneticist and a directeur de recherche (research director) with the French National Centre for Scientific Research in Talence, France.

Education and career

[edit]

Crusio received his bachelor's degree in biology from Radboud University Nijmegen in 1975, where he went on to obtain a master's degree and then a PhD in 1979 and 1984, respectively.[1] His Anubias revision, which was originally published in 1979,[1] was translated in German[2] and continues to engender interest.[3] For his PhD thesis, Crusio studied the inheritance of the effects of anosmia on exploratory behavior of mice, and more in general the genetic architecture of exploratory behavior, using quantitative-genetic methods such as the diallel cross.[4] From 1984 to 1987, Crusio worked as a postdoc at the University of Heidelberg, supported by a NATO Science Fellowship[5] and an Alexander von Humboldt Research Fellowship.[6] During 1988, Crusio spent a year in Paris, France, supported by a fellowship from the Fyssen Foundation.[7] He then returned to Heidelberg as a senior research scientist before being recruited as chargé de recherche by the CNRS, initially working in an institute of the Université René Descartes (Paris V) and later moving to the CNRS campus in Orléans, having been promoted to directeur de recherche.[5] In 2000 he became full professor of psychiatry at the University of Massachusetts Medical School in Worcester, Massachusetts, returning to the CNRS in 2005 as a group leader in the Centre de Neurosciences Intégratives et Cognitives in Talence, a suburb of Bordeaux.[5][8][9] He is currently adjunct director of the Institut de Neurosciences Cognitives et Intégratives d'Aquitaine.[10]

Research

[edit]

Hippocampal mossy fibers

[edit]

Crusio and his collaborators found that neuroanatomical variations in the mouse hippocampus, in particular the sizes of their intra- and infrapyramidal mossy fibers (IIPMF) correlated with learning performance.[11] Together with Herbert Schwegler and Hans-Peter Lipp, Crusio showed that an inverse correlation, that is, animals with larger IIPMF learn better, could be found for spatial learning in a radial arm maze task.[12][13][14] Taken together, Crusio and collaborators think that it is highly likely that this correlation is causal,[15] although this is not universally accepted.[16]

Mouse model of depression

[edit]

When mice are exposed to unpredictable chronic mild stress (UCMS), they start exhibiting symptoms reminiscent of major depressive disorder in humans.[17] As it had been suggested that deficits in hippocampal neurogenesis might underlie depression,[18] Crusio and collaborators undertook a series of experiments investigating changes in behavior and neurogenesis in mice that had undergone UCMS. They showed dramatic changes in levels of aggression,[19] anxiety,[20][21] depressive-like behaviors,[20] and learning,[22] with a concomitant drop in neurogenesis.[22] However, the results were strain- and sex-specific and there did not appear to be a clear-cut correlation between the different changes, so that they finally concluded that although their data do not disprove the idea that deficits in hippocampal neurogenesis solely underlie the behavioral impairments observed in human psychiatric disorders such as depression, they do not provide support for this hypothesis either.[22]

Mouse model of autism

[edit]

More recently, Crusio has been investigating the possibility that Fmr1 knockout mice might perhaps be used as a model for autism. This idea is based on the fact that patients suffering from the Fragile X syndrome, caused by a deficiency of the FMR1 gene often show autistic symptoms. A good mouse model for the Fragile X syndrome is available in the form of mice in which the Fmr1 gene (the mouse homologue of the human FMR1 gene) has been invalidated.[23] A review of the findings obtained with these mice in many different laboratories did indeed indicate that these animals display autistic-like symptoms,[24] especially changes in social behavior, a key symptom of autism.[25][26]

Editorial activities

[edit]

Crusio is the founding editor-in-chief of Genes, Brain and Behavior, which he edited from 2001 to 2011.[27] The standards for the publication of mouse mutant studies that he and his co-editors developed for this journal[28] are gradually being accepted in the field.[29][30][31] Since 2017, Crusio is the editor-in-chief of Behavioral and Brain Functions[32] and since 2019 co-editor of Advances in Experimental Medicine and Biology.[33] He is also an academic editor of PLoS ONE and served as associate editor of Behavioral and Brain Sciences (1991–2008) and The Scientific World Journal (2002-2011). Crusio serves or has served on the editorial boards of Behavioral and Brain Functions, Behavior Genetics (1991–1995), Behavioural Brain Research (1997–2007), BMC Neuroscience, BMC Research Notes, Frontiers in Behavioral Neuroscience, Journal of Visualized Experiments, Molecular Brain (2012-2017), Neurogenetics (1998–2006), Physiology and Behavior, and Current Opinion in Behavioral Sciences. He edited special issues for the journals Behavior Genetics,[34] Behavioural Brain Research,[35] Physiology and Behavior (with Robert Gerlai),[36] Hippocampus (with Aryeh Routtenberg),[37] and Brain Research Bulletin (with Catherine Belzung and Robert Gerlai).[38] Together with Robert Gerlai he also edited a handbook on molecular genetic techniques for behavioral neuroscience.[39][40][41] Currently, he is editing the Cambridge Handbooks in Behavioral Genetics, a series of handbooks published by Cambridge University Press,[42] of which the first volume, Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes, appeared in 2013.[43][44] Since then, two more volumes have appeared.[45]

Community service

[edit]

In 1996, Crusio was one of two co-founders of the International Behavioural and Neural Genetics Society,[46] for which he served as member-at-large of the executive committee, treasurer, and president (1998–2001).[47] In 2011 he received from this society the "Distinguished Service Award",[48] which is given for exceptional contributions to the field of behavioral neurogenetics.[49] Crusio also served on the executive committees of the Behavior Genetics Association (from which he resigned in protest to Glayde Whitney's 1995 presidential address),[50][51] the European Brain and Behaviour Society,[52] and the International Behavioral Neuroscience Society,[53] and has been a President of the Dutch Behavior Genetics Contact Group.[54] He has been a member of several program committees for scientific meetings, most notably the 8th and 10th[55] World Congresses of Psychiatric Genetics and the 2008, 2009 (co-chair), 2010 (chair), and 2011 (chair) Annual Meetings of the IBNS.[56]

Significant papers

[edit]
Scholia has a profile for Wim Crusio (Q120981).

According to Google Scholar, Crusio's works have been cited over 10,000 times and he has an h-index of 46.[57] Some significant papers are:

  • Crusio, W. E.; Genthner-Grimm, G.; Schwegler, H. (2007). "A quantitative-genetic analysis of hippocampal variation in the mouse". Journal of Neurogenetics. 21 (4, Special Retrospective Issue: The Origins of Neurogenetics): 197–208. doi:10.1080/01677060701715827. PMID 18161583. S2CID 7334116. Original publication: Crusio, W. E.; Genthner-Grimm, G.; Schwegler, H. (July 1986). "A quantitative-genetic analysis of hippocampal variation in the mouse". Journal of Neurogenetics. 3 (4): 203–214. doi:10.3109/01677068609106850. PMID 3746523.
  • Crusio, W. E.; Schwegler, H.; Lipp, H. P. (November 1987). "Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution". Brain Research. 425 (1): 182–185. doi:10.1016/0006-8993(87)90498-7. PMID 3427419. S2CID 39198617.
  • Crusio, W. E.; Schwegler, H.; van Abeelen, J. H. F. (February 1989). "Behavioral responses to novelty and structural variation of the hippocampus in mice. II. Multivariate genetic analysis". Behavioural Brain Research. 32 (1): 81–88. doi:10.1016/S0166-4328(89)80075-0. PMID 2930637. S2CID 42291976.
  • Crusio W. E. (November 2001). "Genetic dissection of mouse exploratory behaviour". Behavioural Brain Research. 125 (1–2): 127–132. doi:10.1016/S0166-4328(01)00280-7. PMID 11682103. S2CID 28031277.
  • Crusio, W. E.; Goldowitz, D.; Holmes, A.; Wolfer, D. (February 2009). "Standards for the publication of mouse mutant studies". Genes, Brain and Behavior. 8 (1): 1–4. doi:10.1111/j.1601-183X.2008.00438.x. PMID 18778401. S2CID 205853147.

References

[edit]
  1. ^ a b "Wim E. Crusio Curriculum Vitae" (PDF). Wim E. Crusio Blog. February 2016. Archived from the original (PDF) on 7 November 2017. Retrieved 15 August 2018.
  2. ^ Brünner, Gerhard (1987). "Crusio, Wim: Die Gattung Anubias (Araceae)". Für Ihre Bücherei. Aquarien Magazin (in German). 21 (7).
  3. ^ Klix, Wolf-Dieter (2009). "Protokoll der Mitgliederversammlung 2009 des Arbeitskreises Wasserpflanzen in Dresden". Aqua Planta (in German). 34 (4): 150–151. Archived from the original on 7 October 2010. Retrieved 22 August 2010. Announcement of re-issue on CD of 1987 German edition of Anubias revision
  4. ^ Crusio, WE (1984). Olfaction and behavioral responses to novelty in mice: A quantitative-genetic analysis. Meppel: Krips Repro. pp. viii+146+78. Archived from the original on 14 August 2016. Retrieved 31 July 2016.
  5. ^ a b c "Curriculum Vitae Wim E. Crusio". Archived from the original on 30 January 2017. Retrieved 15 August 2018.
  6. ^ "Publications by Humboldt Research Fellows from abroad in 2005: Biosciences, Life Sciences". Archived from the original on 27 September 2011. Retrieved 11 August 2009.
  7. ^ "Liste des boursiers 1987/1988". Annales de la Fondation Fyssen. 4. 1989.
  8. ^ "CNIC UMR5228 – Equipe 3 – Neurogénétique comportementale" (in French). Archived from the original on 30 October 2007. Retrieved 15 August 2009.
  9. ^ Deris, Yves. "Nouvel arrivant à l'INB, aujourd'hui : Wim CRUSIO" (in French). Institut des Neurosciences de Bordeaux. Archived from the original on 17 July 2009. Retrieved 23 August 2009.
  10. ^ "Crusio Wim". The Aquitaine Institute for Cognitive and Integrative Neuroscience. Archived from the original on 21 October 2014. Retrieved 29 December 2012.
  11. ^ Chapouthier, Georges (1994). La Biologie de la Mémoire. Que sais-je? (in French). Presses Universitaires de France. p. 128. ISBN 2-13-046261-8.
  12. ^ Crusio, W. E.; Schwegler, H; Lipp, H. P. (November 1987). "Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution". Brain Research. 425 (1): 182–185. doi:10.1016/0006-8993(87)90498-7. PMID 3427419. S2CID 39198617.
  13. ^ Schwegler, H; Crusio, W. E.; Brust, I (1990). "Hippocampal mossy fibers and radial-maze learning in the mouse: a correlation with spatial working memory but not with non-spatial reference memory". Neuroscience. 34 (2): 293–298. doi:10.1016/0306-4522(90)90139-U. PMID 2333144. S2CID 9557091.
  14. ^ Crawley, Jacqueline (2007). What's Wrong with My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice. John Wiley & Sons. p. 138. ISBN 9780470119044. Archived from the original on 10 May 2016. Retrieved 8 February 2015.
  15. ^ Crusio, W. E.; Schwegler, H (April 2005). "Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice". Behavioral and Brain Functions. 1 (3): 3. doi:10.1186/1744-9081-1-3. PMC 1143776. PMID 15916698.
  16. ^ Morris, R. (2007). "Theories of hippocampal function". In Andersen, P.; Morris, R.; Amaral, D.; Bliss, T.; O'Keefe, J. (eds.). The Hippocampus Book. Oxford, UK: Oxford University Press. pp. 581–713. ISBN 978-0-19-510027-3.
  17. ^ Willner P (December 1997). "Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation". Psychopharmacology. 134 (4): 319–329. doi:10.1007/s002130050456. PMID 9452163. S2CID 40941720. Archived from the original on 30 April 1999. Retrieved 15 August 2009.
  18. ^ Kempermann, G; Kronenberg, G (September 2003). "Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression". Biological Psychiatry. 54 (5): 499–503. doi:10.1016/S0006-3223(03)00319-6. PMID 12946878. S2CID 26823096.
  19. ^ Mineur, Y. S.; Prasol, D. J.; Belzung, C; Crusio, W. E. (September 2003). "Agonistic behavior and unpredictable chronic mild stress in mice" (PDF). Behavior Genetics. 33 (5): 513–519. doi:10.1023/A:1025770616068. PMID 14574128. S2CID 20402648. Retrieved 16 August 2009.[permanent dead link‍]
  20. ^ a b Mineur, Y. S.; Belzung, C; Crusio, W. E. (November 2006). "Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice". Behavioural Brain Research. 175 (1): 43–50. doi:10.1016/j.bbr.2006.07.029. PMID 17023061. S2CID 28014881.
  21. ^ Wahlsten, Douglas (2010). Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience. Academic Press. p. 166. ISBN 9780123756756. Archived from the original on 3 June 2016. Retrieved 6 February 2015.
  22. ^ a b c Mineur, Y. S.; Belzung, C; Crusio, W. E. (December 2007). "Functional implications of decreases in neurogenesis following chronic mild stress in mice". Neuroscience. 150 (2): 251–259. doi:10.1016/j.neuroscience.2007.09.045. PMID 17981399. S2CID 25560162.
  23. ^ The Dutch-Belgian Fragile X Consortium (July 1994). "Fmr1 knockout mice: a model to study fragile X mental retardation". Cell. 78 (1): 23–33. doi:10.1016/0092-8674(94)90569-X. PMID 8033209. S2CID 29674883.
  24. ^ Bernardet, M; Crusio, W. E. (2006). "Fmr1 KO mice as a possible model of autistic features". The Scientific World Journal. 6: 1164–1176. doi:10.1100/tsw.2006.220. PMC 5917219. PMID 16998604.
  25. ^ Mineur, Y. S.; Huynh, L. X.; Crusio, W. E. (March 2006). "Social behavior deficits in the Fmr1 mutant mouse". Behavioural Brain Research. 168 (1): 172–175. doi:10.1016/j.bbr.2005.11.004. PMID 16343653. S2CID 45731129.
  26. ^ Spencer, C. M.; Alekseyenko, O; Serysheva, E; Yuva-Paylor, L. A.; Paylor, R (October 2005). "Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome". Genes, Brain and Behavior. 4 (7): 420–430. doi:10.1111/j.1601-183X.2005.00123.x. PMID 16176388. S2CID 9094269.
  27. ^ Pagel, Mark (7 May 2004). "The order in a billion sequences". Times Higher Education. Archived from the original on 3 April 2012. Retrieved 9 July 2010.
  28. ^ Crusio, W. E.; Goldowitz, D; Holmes, A; Wolfer, D (February 2009). "Standards for the publication of mouse mutant studies". Genes, Brain and Behavior. 8 (1): 1–4. doi:10.1111/j.1601-183X.2008.00438.x. PMID 18778401. S2CID 205853147.
  29. ^ "Author Guidelines". European Journal of Neuroscience. CiteSeerX 10.1.1.721.6506. doi:10.1111/(ISSN)1460-9568.
  30. ^ Editorial (September 2009). "Troublesome variability in mouse studies". Nature Neuroscience. 12 (9): 1075. doi:10.1038/nn0909-1075. PMID 19710643.
  31. ^ "Preparing your manuscript – Research – Criteria". Behavioral and Brain Functions. BioMed Central. Archived from the original on 3 June 2021. Retrieved 5 May 2020.
  32. ^ "Editorial Board". Behavioral and Brain Functions. BioMed Central. Archived from the original on 19 September 2020. Retrieved 25 August 2017.
  33. ^ "Advances in Experimental Medicine and Biology". Springer Nature. Archived from the original on 30 November 2019. Retrieved 30 October 2019.
  34. ^ Crusio, Wim E. (September 1996). Crusio WE (ed.). "Special issue: The neurobehavioral genetics of aggression". Behavior Genetics. 26 (5): 459–504. doi:10.1007/BF02359749. PMID 8917943. S2CID 31579336. Archived from the original on 25 August 2017. Retrieved 14 August 2009.
  35. ^ Crusio WE, ed. (September 1998). "Special issue: The genetic dissection of brain-behaviour relationships: An introduction to neurobehavioural genetics". Behavioural Brain Research. 95 (1): 1–142. doi:10.1016/S0166-4328(97)00203-9. S2CID 208791454. Archived from the original on 13 March 2013. Retrieved 14 August 2009.
  36. ^ Gerlai RT (August 2001). Gerlai RT, Crusio WE (eds.). "Special issue: Bridging the gap from gene to behavior: Recombinant DNA techniques merge with behavioral neurobiology". Physiology and Behavior. 73 (5): 671–886. doi:10.1016/S0031-9384(01)00583-2. S2CID 54311109. Archived from the original on 24 September 2015. Retrieved 14 August 2009.
  37. ^ Crusio WE, Routtenberg A (February 2001). Routtenberg A, Crusio WE (eds.). "Special Issue: Gene Targeting and Hippocampal Function". Hippocampus. 12 (1): 2–3. doi:10.1002/hipo.10001. PMID 11918284. S2CID 37535269. Archived from the original on 22 October 2012. Retrieved 14 August 2009.
  38. ^ Belzung C, Crusio WE, Gerlai RT (January 2002). Belzung C, Crusio WE, Gerlai RT (eds.). "Special issue: Behavioral neurogenetics, the genetic dissection of brain and behavior". Brain Research Bulletin. 57 (1): 1–131. doi:10.1016/S0361-9230(01)00629-3. PMID 11827730. S2CID 9742148. Archived from the original on 24 September 2015. Retrieved 14 August 2009.
  39. ^ Crusio, WE; Gerlai, RT (1999). Handbook of Molecular-Genetic Techniques for Brain and Behavior Research. Amsterdam: Elsevier. pp. xxvii+965. ISBN 978-0-444-50239-1.
  40. ^ "Crusio, W.E. [WorldCat Identities]". Archived from the original on 17 December 2013. Retrieved 11 August 2009.
  41. ^ Skoulakis, Efthimios M.C. (2001). "A tool for synthesis". Trends in Neurosciences. 24 (2): 127. doi:10.1016/S0166-2236(00)01670-2. S2CID 53185722. Reprinted in: Skoulakis, Efthimios M.C (2001). "A tool for synthesis". Trends in Molecular Medicine. 7 (3): 139. doi:10.1016/S1471-4914(01)01956-6.
  42. ^ "Series – Cambridge Handbooks in Behavioral Genetics". Cambridge University Press. Archived from the original on 25 September 2015. Retrieved 25 November 2012.
  43. ^ Mandillo, Silvia (2014). "Book review: Behavioral Genetics of the Mouse". Genes, Brain and Behavior. 13 (5): 517. doi:10.1111/gbb.12125.
  44. ^ Michetti, Caterina (2014). "BEHAVIORAL GENETICS OF THE MOUSE. Genetics of Behavioral Phenotypes. Volume 1" (PDF). Annali dell'Istituto Superiore di Sanità. 50 (4): 378–379. doi:10.4415/ANN_14_04_14. Archived (PDF) from the original on 8 August 2016. Retrieved 31 July 2016.
  45. ^ "Cambridge Handbooks in Behavioral Genetics". Cambridge, United Kingdom: Cambridge University Press. Archived from the original on 2 October 2021. Retrieved 29 October 2015.
  46. ^ "IBANGS History". IBANGS Homepage. Archived from the original on 26 July 2011. Retrieved 1 April 2009.
  47. ^ "Past Officers and Executive Committee Members". Archived from the original on 9 March 2012. Retrieved 9 March 2012.
  48. ^ "IBANGS Awards". IBANGS Homepage. Archived from the original on 1 October 2011. Retrieved 25 November 2011.
  49. ^ "Call for 2011 IBANGS award nominations". IBANGS Homepage. Archived from the original on 1 October 2011. Retrieved 25 November 2011.
  50. ^ Loehlin, John (1 April 2009). "History of behavior genetics". In Kim, Yong-Kyu (ed.). Handbook of Behavior Genetics. Berlin: Springer. pp. 3–11. ISBN 978-0-387-76726-0. Archived from the original on 2 October 2021. Retrieved 17 December 2020.
  51. ^ Panofsky, Aaron (2014). Misbehaving Science. Controversy and the Development of Behavior Genetics. Chicago: University of Chicago Press. pp. 3–4. ISBN 978-0-226-05831-3.
  52. ^ "Past committee members". Archived from the original on 14 March 2012. Retrieved 11 August 2009.
  53. ^ "IBNS History of Officers". Archived from the original on 21 November 2008. Retrieved 11 August 2009.
  54. ^ Crusio, W.E. (1991). "Obituary Sjeng Kerbusch (1947-1991)". Behavior Genetics. 21 (5): 431–432. doi:10.1007/BF01066721. S2CID 148069790.
  55. ^ "Xth World Congress on Psychiatric Genetics – Committees". Archived from the original on 30 September 2002. Retrieved 9 July 2010.
  56. ^ "IBNS Committees/Mission Statements". Archived from the original on 4 May 2009. Retrieved 11 August 2009.
  57. ^ "Wim Crusio". Google Scholar. Retrieved 16 May 2022.
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