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{{chembox
{{chembox
| Verifiedfields = changed
| verifiedrevid = 414843184
| verifiedrevid = 470455587
| Name = GV (nerve agent)
| Name = GV
| OtherNames = EA-5365
| ImageFile1 = GV-2D-skeletal.png
| ImageFile1 = GV-2D-skeletal.png
| ImageName1 = Skeletal formula of GV
| ImageName1 = Skeletal formula of GV
Line 16: Line 18:
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = JJHAGEZAXYOCMC-UHFFFAOYSA-N
| StdInChIKey = JJHAGEZAXYOCMC-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|??}}
| CASNo_Ref = {{cascite|changed|??}}
| CASNo = 141102-74-1
| CASNo = 141102-74-1
| SMILES = FP(=O)(N(C)C)CCN(C)C
| SMILES = FP(=O)(N(C)C)CCN(C)C
| PubChem = 132333
| PubChem = 132333

}}
}}
| Section2 = {{Chembox Properties
| Section2 = {{Chembox Properties
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}}
}}


'''GV''' ([[IUPAC]] name: '''2-(Dimethylamino)ethyl ''N'',''N''-dimethylphosphoramidofluoridate''') is an [[organophosphate]] [[nerve agent]]. GV is a part of a new series of nerve agents with properties similar to both the "G-series" and "V-series". It is a potent [[acetylcholinesterase]] inhibitor with properties similar to other nerve agents, being a highly poisonous vapour. Treatment for poisoning with GV involves drugs such as [[atropine]], [[benactyzine]], [[obidoxime]] and [[HI-6]].<ref>Fusek J, Bajgar J. Treatment of intoxication with GV compound in laboratory rats. ''Sbornik Vedeckych Praci Lekarske Fakulty Karlovy Univerzity v Hradci Kralove''. 1994;37(2):57-62. PMID 7784799</ref><ref>Kassa J, Bajgar J. Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice. ''Acta Medica (Hradec Kralove)''. 1996;39(1):27-30. PMID 9106387</ref>
'''GV''' ([[IUPAC]] name: '''2-(Dimethylamino)ethyl ''N'',''N''-dimethylphosphoramidofluoridate'''), also known as '''EA-5365''', is an [[organophosphate]] [[nerve agent]]. GV is a part of a new series of nerve agents with properties similar to the "G-series" and "V-series". It is a potent [[acetylcholinesterase]] inhibitor with properties similar to other nerve agents, being a highly poisonous vapour. Treatment for poisoning with GV involves drugs such as [[atropine]], [[benactyzine]], [[obidoxime]], and [[HI-6]].<ref>{{ cite journal | vauthors = Fusek J, Bajgar J | title = Treatment of intoxication with GV compound in laboratory rats | journal = Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove | year = 1994 | volume = 37 | issue = 2 | pages = 57–62 | pmid = 7784799 }}</ref><ref>{{ cite journal | vauthors = Kassa J, Bajgar J | title = Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice | journal = Acta Medica (Hradec Kralove) | year = 1996 | volume = 39 | issue = 1 | pages = 27–30 | pmid = 9106387 }}</ref>

⚫
==References==
<references/>


==See also==
==See also==
*[[Fluorotabun]]
*[[Methylfluorophosphonylcholine]]
*[[VG (nerve agent)]]
*[[VG (nerve agent)]]

⚫
==References==
{{reflist}}


==External links==
==External links==
{{Commons category|GV nerve agent}}
{{Commons category|GV nerve agent}}
*{{cite web | vauthors = Harvey SP, Cheng TC | title = Identification, Purification, and Partial Characterization of the GV-Degrading Enzyme from ATCC # 29660 ''Alteromonas undina'' | publisher = Edgewood | location = Aberdeen Proving Ground | year = 2002 | id = Report ECBC-TR-229 | oclc = 74239874 | url = http://www.dtic.mil/cgi-bin/GetTRDoc?Location=U2&doc=GetTRDoc.pdf&AD=ADA411415 | format = pdf | access-date = 2013-09-09 | archive-date = 2013-09-09 | archive-url = https://web.archive.org/web/20130909103146/http://www.dtic.mil/cgi-bin/GetTRDoc?Location=U2&doc=GetTRDoc.pdf&AD=ADA411415 | url-status = dead }}
*[http://stinet.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA411415 Identification, Purification, and Partial Characterization of the GV-Degrading Enzyme from ATCC # 29660 Alteromonas Undina]
*[http://www.asanltr.com/ASANews-98/chemistry.html Some Toxic Chemicals as Potential Chemical Warfare Agents - The Threat for the Future?]
*{{ cite journal | author = Bajgar J | title = Some Toxic Chemicals as Potential Chemical Warfare Agents - The Threat for the Future? | journal = ASA Newsletter | year = 1998 | volume = 1998 | issue = 6 | url = http://www.asanltr.com/ASANews-98/chemistry.html }}


{{Chemical warfare}}
{{Chemical warfare}}
{{Acetylcholine metabolism and transport modulators}}
{{Cholinergics}}
{{Neurotoxins}}


[[Category:Amines]]
[[Category:Acetylcholinesterase inhibitors]]
[[Category:Dimethylamino compounds]]
[[Category:Phosphorofluoridates]]
[[Category:Phosphorofluoridates]]
[[Category:Anticholinesterases]]
[[Category:G-series nerve agents]]
[[Category:Nerve agents]]
[[Category:Phosphorus-nitrogen compounds]]


{{organic-compound-stub}}
{{Organic-compound-stub}}

Latest revision as of 11:57, 14 November 2024

GV
Ball-and-stick model of GV
Skeletal formula of GV
Names
IUPAC name
2-(Dimethylamino)ethyl N,N-dimethylphosphoramidofluoridate
Other names
EA-5365
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C6H16FN2OP/c1-8(2)5-6-11(7,10)9(3)4/h5-6H2,1-4H3 checkY
    Key: JJHAGEZAXYOCMC-UHFFFAOYSA-N checkY
  • InChI=1/C6H16FN2OP/c1-8(2)5-6-11(7,10)9(3)4/h5-6H2,1-4H3
    Key: JJHAGEZAXYOCMC-UHFFFAOYAS
  • FP(=O)(N(C)C)CCN(C)C
Properties
C6H16FN2O2P
Molar mass 198.176 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

GV (IUPAC name: 2-(Dimethylamino)ethyl N,N-dimethylphosphoramidofluoridate), also known as EA-5365, is an organophosphate nerve agent. GV is a part of a new series of nerve agents with properties similar to the "G-series" and "V-series". It is a potent acetylcholinesterase inhibitor with properties similar to other nerve agents, being a highly poisonous vapour. Treatment for poisoning with GV involves drugs such as atropine, benactyzine, obidoxime, and HI-6.[1][2]

See also

[edit]

References

[edit]
  1. ^ Fusek J, Bajgar J (1994). "Treatment of intoxication with GV compound in laboratory rats". Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 37 (2): 57–62. PMID 7784799.
  2. ^ Kassa J, Bajgar J (1996). "Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice". Acta Medica (Hradec Kralove). 39 (1): 27–30. PMID 9106387.
[edit]
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