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{{cs1 config|name-list-style=vanc}}
{{Short description|Protein found in humans}}
{{Short description|Protein found in humans}}
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{{cs1 config|name-list-style=vanc}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Dedicator of cytokinesis protein 1''' ('''Dock1'''), also '''(DOCK180)''', is a large (~180 kDa) [[protein]] encoded in the human by the ''DOCK1'' gene, involved in [[intracellular]] [[cell signalling|signalling networks]].<ref name="entrez">{{cite web | title = Entrez Gene: DOCK1 dedicator of cytokinesis 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1793}}</ref> It is the mammalian [[ortholog]] of the ''[[Caenorhabditis elegans|C. elegans]]'' protein [[CED-5]] and belongs to the [[DOCK (protein)|DOCK]] family of [[guanine nucleotide exchange factors]] (GEFs).<ref name="Meller_2005">{{cite journal | vauthors = Meller N, Merlot S, Guda C | title = CZH proteins: a new family of Rho-GEFs | journal = J. Cell Sci. | volume = 118 | issue = Pt 21 | pages = 4937–46 |date=November 2005 | pmid = 16254241 | doi = 10.1242/jcs.02671| s2cid = 3075895 | doi-access = }}</ref>
'''Dedicator of cytokinesis protein 1''' ('''Dock1'''), also '''(DOCK180)''', is a large (~180 kDa) [[protein]] encoded in the human by the ''DOCK1'' gene, involved in [[intracellular]] [[cell signalling|signalling networks]].<ref name="entrez">{{cite web | title = Entrez Gene: DOCK1 dedicator of cytokinesis 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1793}}</ref> It is the mammalian [[ortholog]] of the ''[[Caenorhabditis elegans|C. elegans]]'' protein [[CED-5]] and belongs to the [[DOCK (protein)|DOCK]] family of [[guanine nucleotide exchange factors]] (GEFs).<ref name="Meller_2005">{{cite journal | vauthors = Meller N, Merlot S, Guda C | title = CZH proteins: a new family of Rho-GEFs | journal = J. Cell Sci. | volume = 118 | issue = Pt 21 | pages = 4937–46 |date=November 2005 | pmid = 16254241 | doi = 10.1242/jcs.02671| s2cid = 3075895 | doi-access = }}</ref>
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==Regulation of DOCK180 Activity==
==Regulation of DOCK180 Activity==
Under physiological conditions DOCK180 alone is inefficient at promoting nucleotide exchange on Rac.<ref name="Brugnera_2002"/> Effective GEF activity requires an interaction between Dock180 and its binding partner [[ELMO (protein)|ELMO]]. [[ELMO1]] is the most comprehensively described [[isoform]] of this small family of non-[[Biocatalysis|catalytically]] active proteins which function to recruit Dock180 to the [[plasma membrane]] and induce conformational changes which increase GEF efficiency.<ref name="Lu_2006">{{cite book | vauthors = Lu M, Ravichandran KS | chapter = Dock180–ELMO Cooperation in Rac Activation| title = Regulators and Effectors of Small GTPases: Rho Family| journal = Meth. Enzymol. | volume = 406 | pages = 388–402 | year = 2006 | pmid = 16472672 | doi = 10.1016/S0076-6879(06)06028-9| series = Methods in Enzymology| isbn = 9780121828110}}</ref><ref name="Lu_2004">{{cite journal | vauthors = Lu M, Kinchen JM, Rossman KL | title = PH domain of ELMO functions ''in trans'' to regulate Rac activation via Dock180| journal = Nature Structural & Molecular Biology | volume = 11 | issue = 8 | pages = 756–62 | year = 2004 | pmid = 15247908 | doi = 10.1038/nsmb800| s2cid = 125990|display-authors=etal}}</ref><ref name="Lu_2005">{{cite journal | vauthors = Lu M, Kinchen JM, Rossman KL | title = A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs| journal = Curr. Biol. | volume = 15 | issue = 4 | pages = 371–77 |date=February 2005 | pmid = 15723800 | doi = 10.1016/j.cub.2005.01.050| s2cid = 14267018|display-authors=etal| doi-access = free }}</ref> ELMO1 has also been reported to inhibit [[Ubiquitin|ubiqitinylation]] of Dock180 and so prevent its degradation by [[proteasomes]].<ref name="Makino_2006">{{cite journal | vauthors = Makino Y, Tsuda M, Ichihara S | title = Elmo1 inhibits ubiquitylation of Dock180| journal = J. Cell Sci. | volume = 119 | issue = Pt 5 | pages = 923–32 |date=March 2006 | pmid = 16495483 | doi = 10.1242/jcs.02797| s2cid = 15035869|display-authors=etal| doi-access = }}</ref> [[Receptor (biochemistry)|Receptor]]-mediated activation of [[RhoG]] (a small G protein of the [[Rac (GTPase)|Rac subfamily]]) is perhaps the best known inducer of Dock180 GEF activity. Active (GTP-bound) RhoG recruits the ELMO/Dock180 complex to the plasma membrane thereby bringing Dock180 into contact with its [[Substrate (biochemistry)|substrate]], Rac.<ref name="Katoh_2003">{{cite journal | vauthors = Katoh H, Negishi M| title = RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo| journal = Nature | volume = 424 | issue = 6947 | pages = 461–64 |date=July 2003 | pmid = 12879077 | doi = 10.1038/nature01817| bibcode = 2003Natur.424..461K| s2cid = 4411133}}</ref> In [[tumour]] cells DOCK180 is regulated by a complex containing Crk and [[BCAR1|p130Cas]] which is in turn regulated by cooperative signalling by [[Integrin beta 3|β<sub>3</sub>-containing]] [[integrin]] complexes and the membrane-bound protein [[uPAR]].<ref name="Smith_2008">{{cite journal | vauthors = Smith HW, Marra P, Marshall CJ| title = uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180| journal = J. Cell Biol. | volume = 182 | issue = 4 | pages = 777–90 |date=August 2008 | pmid = 18725541 | doi = 10.1083/jcb.200712050| pmc = 2518715 }}</ref>
Under physiological conditions DOCK180 alone is inefficient at promoting nucleotide exchange on Rac.<ref name="Brugnera_2002"/> Effective GEF activity requires an interaction between Dock180 and its binding partner [[ELMO (protein)|ELMO]]. [[ELMO1]] is the most comprehensively described [[isoform]] of this small family of non-[[Biocatalysis|catalytically]] active proteins which function to recruit Dock180 to the [[plasma membrane]] and induce conformational changes which increase GEF efficiency.<ref name="Lu_2006">{{cite book | vauthors = Lu M, Ravichandran KS | chapter = Dock180–ELMO Cooperation in Rac Activation| title = Regulators and Effectors of Small GTPases: Rho Family| volume = 406 | pages = 388–402 | year = 2006 | pmid = 16472672 | doi = 10.1016/S0076-6879(06)06028-9| series = Methods in Enzymology| isbn = 978-0-12-182811-0}}</ref><ref name="Lu_2004">{{cite journal | vauthors = Lu M, Kinchen JM, Rossman KL | title = PH domain of ELMO functions ''in trans'' to regulate Rac activation via Dock180| journal = Nature Structural & Molecular Biology | volume = 11 | issue = 8 | pages = 756–62 | year = 2004 | pmid = 15247908 | doi = 10.1038/nsmb800| s2cid = 125990|display-authors=etal}}</ref><ref name="Lu_2005">{{cite journal | vauthors = Lu M, Kinchen JM, Rossman KL | title = A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs| journal = Curr. Biol. | volume = 15 | issue = 4 | pages = 371–77 |date=February 2005 | pmid = 15723800 | doi = 10.1016/j.cub.2005.01.050| s2cid = 14267018|display-authors=etal| doi-access = free | bibcode = 2005CBio...15..371L}}</ref> ELMO1 has also been reported to inhibit [[Ubiquitin|ubiquitinylation]] of Dock180 and so prevent its degradation by [[proteasomes]].<ref name="Makino_2006">{{cite journal | vauthors = Makino Y, Tsuda M, Ichihara S | title = Elmo1 inhibits ubiquitylation of Dock180| journal = J. Cell Sci. | volume = 119 | issue = Pt 5 | pages = 923–32 |date=March 2006 | pmid = 16495483 | doi = 10.1242/jcs.02797| s2cid = 15035869|display-authors=etal| doi-access = }}</ref> [[Receptor (biochemistry)|Receptor]]-mediated activation of [[RhoG]] (a small G protein of the [[Rac (GTPase)|Rac subfamily]]) is perhaps the best known inducer of Dock180 GEF activity. Active (GTP-bound) RhoG recruits the ELMO/Dock180 complex to the plasma membrane thereby bringing Dock180 into contact with its [[Substrate (biochemistry)|substrate]], Rac.<ref name="Katoh_2003">{{cite journal | vauthors = Katoh H, Negishi M| title = RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo| journal = Nature | volume = 424 | issue = 6947 | pages = 461–64 |date=July 2003 | pmid = 12879077 | doi = 10.1038/nature01817| bibcode = 2003Natur.424..461K| s2cid = 4411133}}</ref> In [[tumour]] cells DOCK180 is regulated by a complex containing Crk and [[BCAR1|p130Cas]] which is in turn regulated by cooperative signalling by [[Integrin beta 3|β<sub>3</sub>-containing]] [[integrin]] complexes and the membrane-bound protein [[uPAR]].<ref name="Smith_2008">{{cite journal | vauthors = Smith HW, Marra P, Marshall CJ| title = uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180| journal = J. Cell Biol. | volume = 182 | issue = 4 | pages = 777–90 |date=August 2008 | pmid = 18725541 | doi = 10.1083/jcb.200712050| pmc = 2518715 }}</ref>


==Signalling Downstream of DOCK180==
==Signalling Downstream of DOCK180==
DOCK180 is a Rac-specific GEF and so is responsible for a subset of Rac-specific signalling events. These include [[cell migration]] and [[phagocytosis]] of [[apoptotic]] cells in ''C. elegans'',<ref name="Gumienny_2001">{{cite journal | vauthors = Gumienny TL, Brugnera E, Tosello-Trampont AC| title = CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration| journal = Cell | volume = 107 | issue = 1 | pages = 27–41 |date=October 2001 | pmid = 11595183 | doi = 10.1016/S0092-8674(01)00520-7| s2cid = 15232864| url = https://www.zora.uzh.ch/id/eprint/952/1/Gumienny2001V.pdf|display-authors=etal}}</ref> [[neurite]] outgrowth in [[PC12 cells]]<ref name="Katoh_2000]">{{cite journal | vauthors = Katoh H, Yasui H, Yamaguchi Y| title = Small GTPase RhoG Is a Key Regulator for Neurite Outgrowth in PC12 Cells| journal = Mol. Cell. Biol. | volume = 20 | issue = 19 | pages = 7378–87 |date=October 2000 | pmid = 10982854 | doi = 10.1128/MCB.20.19.7378-7387.2000| pmc = 86291 |display-authors=etal}}</ref> and [[myoblast]] fusion in the [[zebrafish]] embryo.<ref name="Moore_2007]">{{cite journal | vauthors = Moore CA, Parkin CA, Bidet Y| title = A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion| journal = Development | volume = 134 | issue = 17 | pages = 3145–53 |date=September 2007 | pmid = 17670792 | doi = 10.1242/dev.001214|display-authors=etal| doi-access = free }}</ref> More recently the DHR1 domain of DOCK180 was shown to bind [[SNX5]] (a [[sorting nexin]]) and this interaction promoted retrograde transport of the [[insulin-like growth factor 2 receptor|cation-independent mannose 6-phosphate receptor]] to the [[Golgi apparatus|trans-Golgi network]] in a Rac-independent manner.<ref name="Hara_2008]">{{cite journal | vauthors = Hara S, Kiyokawa E, Iemura SI| title = The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport| journal = Mol. Biol. Cell | volume = 19 | issue = 9| pages = 3823–35|date=July 2008 | pmid = 18596235 | doi = 10.1091/mbc.E08-03-0314| pmc = 2526700 |display-authors=etal}}</ref> Increased [[gene expression|expression]] of DOCK180 and Elmo has been reported to contribute to [[glioma]] invasion.<ref name="Jarzynka_2007]">{{cite journal | vauthors = Jarzynka MJ, Hu B, Hui KM| title = ELMO1 and Dock180, a Bipartite Rac1 Guanine Nucleotide Exchange Factor, Promote Human Glioma Cell Invasion| journal = Cancer Res. | volume = 67 | issue = 15 | pages = 7203–11 |date=August 2007 | pmid = 17671188 | doi = 10.1158/0008-5472.CAN-07-0473| pmc = 2867339 |display-authors=etal}}</ref>
DOCK180 is a Rac-specific GEF and so is responsible for a subset of Rac-specific signalling events. These include [[cell migration]] and [[phagocytosis]] of [[apoptotic]] cells in ''C. elegans'',<ref name="Gumienny_2001">{{cite journal | vauthors = Gumienny TL, Brugnera E, Tosello-Trampont AC | title = CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration | journal = Cell | volume = 107 | issue = 1 | pages = 27–41 | date = October 2001 | pmid = 11595183 | doi = 10.1016/S0092-8674(01)00520-7 | s2cid = 15232864 | url = https://www.zora.uzh.ch/id/eprint/952/1/Gumienny2001V.pdf | display-authors = etal | access-date = 2020-09-13 | archive-date = 2021-09-22 | archive-url = https://web.archive.org/web/20210922225900/https://www.zora.uzh.ch/id/eprint/952/1/Gumienny2001V.pdf | url-status = dead }}</ref> [[neurite]] outgrowth in [[PC12 cells]]<ref name="Katoh_2000]">{{cite journal | vauthors = Katoh H, Yasui H, Yamaguchi Y| title = Small GTPase RhoG Is a Key Regulator for Neurite Outgrowth in PC12 Cells| journal = Mol. Cell. Biol. | volume = 20 | issue = 19 | pages = 7378–87 |date=October 2000 | pmid = 10982854 | doi = 10.1128/MCB.20.19.7378-7387.2000| pmc = 86291 |display-authors=etal}}</ref> and [[myoblast]] fusion in the [[zebrafish]] embryo.<ref name="Moore_2007]">{{cite journal | vauthors = Moore CA, Parkin CA, Bidet Y| title = A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion| journal = Development | volume = 134 | issue = 17 | pages = 3145–53 |date=September 2007 | pmid = 17670792 | doi = 10.1242/dev.001214|display-authors=etal| doi-access = free }}</ref> More recently the DHR1 domain of DOCK180 was shown to bind [[SNX5]] (a [[sorting nexin]]) and this interaction promoted retrograde transport of the [[insulin-like growth factor 2 receptor|cation-independent mannose 6-phosphate receptor]] to the [[Golgi apparatus|trans-Golgi network]] in a Rac-independent manner.<ref name="Hara_2008]">{{cite journal | vauthors = Hara S, Kiyokawa E, Iemura SI| title = The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport| journal = Mol. Biol. Cell | volume = 19 | issue = 9| pages = 3823–35|date=July 2008 | pmid = 18596235 | doi = 10.1091/mbc.E08-03-0314| pmc = 2526700 |display-authors=etal}}</ref> Increased [[gene expression|expression]] of DOCK180 and Elmo has been reported to contribute to [[glioma]] invasion.<ref name="Jarzynka_2007]">{{cite journal | vauthors = Jarzynka MJ, Hu B, Hui KM| title = ELMO1 and Dock180, a Bipartite Rac1 Guanine Nucleotide Exchange Factor, Promote Human Glioma Cell Invasion| journal = Cancer Res. | volume = 67 | issue = 15 | pages = 7203–11 |date=August 2007 | pmid = 17671188 | doi = 10.1158/0008-5472.CAN-07-0473| pmc = 2867339 |display-authors=etal}}</ref>


== Interactions ==
== Interactions ==
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* [[BCAR1]],<ref name = pmid12615911>{{cite journal | date = Mar 2003 | vauthors = Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD | title = Differential regulation of cell motility and invasion by FAK | journal = J. Cell Biol. | volume = 160 | issue = 5 | pages = 753–67 | pmid = 12615911 | pmc = 2173366 | doi = 10.1083/jcb.200212114}}</ref>
* [[BCAR1]],<ref name = pmid12615911>{{cite journal | date = Mar 2003 | vauthors = Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD | title = Differential regulation of cell motility and invasion by FAK | journal = J. Cell Biol. | volume = 160 | issue = 5 | pages = 753–67 | pmid = 12615911 | pmc = 2173366 | doi = 10.1083/jcb.200212114}}</ref>
* [[CRK (gene)|CRK]]<ref name = pmid12615911/><ref name = pmid8657152/><ref name = pmid10559471>{{cite journal | date = Nov 1999 | vauthors = Nishihara H, Kobayashi S, Hashimoto Y, Ohba F, Mochizuki N, Kurata T, Nagashima K, Matsuda M | title = Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins | journal = Biochim. Biophys. Acta | volume = 1452 | issue = 2 | pages = 179–87 | pmid = 10559471 | doi = 10.1016/s0167-4889(99)00133-0| doi-access = free }}</ref><ref name = pmid11369773>{{cite journal | date = Jul 2001 | vauthors = Gu J, Sumida Y, Sanzen N, Sekiguchi K | title = Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway | journal = J. Biol. Chem. | volume = 276 | issue = 29 | pages = 27090–7 | pmid = 11369773 | doi = 10.1074/jbc.M102284200| doi-access = free }}</ref><ref name = pmid8662907>{{cite journal | date = Jun 1996 | vauthors = Matsuda M, Ota S, Tanimura R, Nakamura H, Matuoka K, Takenawa T, Nagashima K, Kurata T | title = Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins | journal = J. Biol. Chem. | volume = 271 | issue = 24 | pages = 14468–72 | pmid = 8662907 | doi = 10.1074/jbc.271.24.14468| doi-access = free }}</ref>
* [[CRK (gene)|CRK]]<ref name = pmid12615911/><ref name = pmid8657152/><ref name = pmid10559471>{{cite journal | date = Nov 1999 | vauthors = Nishihara H, Kobayashi S, Hashimoto Y, Ohba F, Mochizuki N, Kurata T, Nagashima K, Matsuda M | title = Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins | journal = Biochim. Biophys. Acta | volume = 1452 | issue = 2 | pages = 179–87 | pmid = 10559471 | doi = 10.1016/s0167-4889(99)00133-0| doi-access = free }}</ref><ref name = pmid11369773>{{cite journal | date = Jul 2001 | vauthors = Gu J, Sumida Y, Sanzen N, Sekiguchi K | title = Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway | journal = J. Biol. Chem. | volume = 276 | issue = 29 | pages = 27090–7 | pmid = 11369773 | doi = 10.1074/jbc.M102284200| doi-access = free }}</ref><ref name = pmid8662907>{{cite journal | date = Jun 1996 | vauthors = Matsuda M, Ota S, Tanimura R, Nakamura H, Matuoka K, Takenawa T, Nagashima K, Kurata T | title = Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins | journal = J. Biol. Chem. | volume = 271 | issue = 24 | pages = 14468–72 | pmid = 8662907 | doi = 10.1074/jbc.271.24.14468| doi-access = free }}</ref>
* [[ELMO1]],<ref name = pmid11595183>{{cite journal | date = Oct 2001 | vauthors = Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS | title = CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration | journal = Cell | volume = 107 | issue = 1 | pages = 27–41 | pmid = 11595183 | doi = 10.1016/s0092-8674(01)00520-7| s2cid = 15232864 | url = https://www.zora.uzh.ch/id/eprint/952/1/Gumienny2001V.pdf }}</ref><ref name = pmid12134158>{{cite journal | date = Aug 2002 | vauthors = Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, Macara IG, Madhani H, Fink GR, Ravichandran KS | title = Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex | journal = Nat. Cell Biol. | volume = 4 | issue = 8 | pages = 574–82 | pmid = 12134158 | doi = 10.1038/ncb824| s2cid = 36363774 }}</ref> and
* [[ELMO1]],<ref name = pmid11595183>{{cite journal | date = Oct 2001 | vauthors = Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS | title = CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration | journal = Cell | volume = 107 | issue = 1 | pages = 27–41 | pmid = 11595183 | doi = 10.1016/s0092-8674(01)00520-7 | s2cid = 15232864 | url = https://www.zora.uzh.ch/id/eprint/952/1/Gumienny2001V.pdf | access-date = 2020-09-13 | archive-date = 2021-09-22 | archive-url = https://web.archive.org/web/20210922225900/https://www.zora.uzh.ch/id/eprint/952/1/Gumienny2001V.pdf | url-status = dead }}</ref><ref name = pmid12134158>{{cite journal | date = Aug 2002 | vauthors = Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, Macara IG, Madhani H, Fink GR, Ravichandran KS | title = Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex | journal = Nat. Cell Biol. | volume = 4 | issue = 8 | pages = 574–82 | pmid = 12134158 | doi = 10.1038/ncb824| s2cid = 36363774 }}</ref> and
* [[Grb2]].<ref name = pmid12615911/><ref name = pmid8657152>{{cite journal | date = Apr 1996 | vauthors = Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M | title = DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane | journal = Mol. Cell. Biol. | volume = 16 | issue = 4 | pages = 1770–6 | pmid = 8657152 | pmc = 231163 | doi = 10.1128/MCB.16.4.1770}}</ref>
* [[Grb2]].<ref name = pmid12615911/><ref name = pmid8657152>{{cite journal | date = Apr 1996 | vauthors = Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M | title = DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane | journal = Mol. Cell. Biol. | volume = 16 | issue = 4 | pages = 1770–6 | pmid = 8657152 | pmc = 231163 | doi = 10.1128/MCB.16.4.1770}}</ref>


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*{{cite journal | vauthors=Côté JF, Vuori K |title=GEF what? Dock180 and related proteins help Rac to polarize cells in new ways |journal=Trends Cell Biol. |volume=17 |issue= 8 |pages= 383–93 |year= 2007 |pmid= 17765544 | pmc=2887429 |doi=10.1016/j.tcb.2007.05.001 }}
*{{cite journal | vauthors=Côté JF, Vuori K |title=GEF what? Dock180 and related proteins help Rac to polarize cells in new ways |journal=Trends Cell Biol. |volume=17 |issue= 8 |pages= 383–93 |year= 2007 |pmid= 17765544 | pmc=2887429 |doi=10.1016/j.tcb.2007.05.001 }}
*{{cite journal | vauthors=Komander D, Patel M, Laurin M |title=An α-Helical Extension of the ELMO1 Pleckstrin Homology Domain Mediates Direct Interaction to DOCK180 and Is Critical in Rac Signaling |journal=Mol. Biol. Cell |volume=19 |issue= 11|pages=4837–51|year= 2008 |pmid= 18768751 |doi=10.1091/mbc.E08-04-0345 | pmc=2575150 |display-authors=etal}}
*{{cite journal | vauthors=Komander D, Patel M, Laurin M |title=An α-Helical Extension of the ELMO1 Pleckstrin Homology Domain Mediates Direct Interaction to DOCK180 and Is Critical in Rac Signaling |journal=Mol. Biol. Cell |volume=19 |issue= 11|pages=4837–51|year= 2008 |pmid= 18768751 |doi=10.1091/mbc.E08-04-0345 | pmc=2575150 |display-authors=etal}}
*{{cite journal | author=Henson PM |title=Engulfment: ingestion and migration with Rac, Rho and TRIO |journal=Curr. Biol. |volume=15 |issue= 1 |pages= R29–30 |year= 2005 |pmid= 15649349 |doi=10.1016/j.cub.2004.12.017 |doi-access=free }}
*{{cite journal | author=Henson PM |title=Engulfment: ingestion and migration with Rac, Rho and TRIO |journal=Curr. Biol. |volume=15 |issue= 1 |pages= R29–30 |year= 2005 |pmid= 15649349 |doi=10.1016/j.cub.2004.12.017 |doi-access=free |bibcode=2005CBio...15..R29H }}
*{{cite journal | vauthors=deBakker CD, Haney LB, Kinchen JM |title=Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO |journal=Curr. Biol. |volume=14 |issue= 24 |pages= 2208–16 |year= 2004 |pmid= 15620647 |doi=10.1016/j.cub.2004.12.029 |s2cid=1269946 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=deBakker CD, Haney LB, Kinchen JM |title=Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO |journal=Curr. Biol. |volume=14 |issue= 24 |pages= 2208–16 |year= 2004 |pmid= 15620647 |doi=10.1016/j.cub.2004.12.029 |s2cid=1269946 |display-authors=etal|doi-access=free |bibcode=2004CBio...14.2208D }}
*{{cite journal | vauthors=Yin J, Haney L, Walk S |title=Nuclear localization of the DOCK180/ELMO complex |journal=Arch. Biochem. Biophys. |volume=429 |issue= 1 |pages= 23–29 |year= 2004 |pmid= 15288806 |doi=10.1016/j.abb.2004.05.014 |display-authors=etal|url=https://zenodo.org/record/1258672 }}
*{{cite journal |vauthors=Yin J, Haney L, Walk S |title=Nuclear localization of the DOCK180/ELMO complex |journal=Arch. Biochem. Biophys. |volume=429 |issue=1 |pages=23–29 |year=2004 |pmid=15288806 |doi=10.1016/j.abb.2004.05.014 |display-authors=etal |url=https://zenodo.org/record/1258672 }}
*{{cite journal | vauthors=Matsuda M, Ota S, Tanimura R |title=Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14468–72 |year= 1996 |pmid= 8662907 |doi=10.1074/jbc.271.24.14468 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Matsuda M, Ota S, Tanimura R |title=Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14468–72 |year= 1996 |pmid= 8662907 |doi=10.1074/jbc.271.24.14468 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Savill J |title=Apoptosis. Phagocytic docking without shocking |journal=Nature |volume=392 |issue= 6675 |pages= 442–3 |year= 1998 |pmid= 9548247 |doi=10.1038/33025 |bibcode=1998Natur.392..442S |s2cid=205002296 |doi-access=free }}
*{{cite journal | author=Savill J |title=Apoptosis. Phagocytic docking without shocking |journal=Nature |volume=392 |issue= 6675 |pages= 442–3 |year= 1998 |pmid= 9548247 |doi=10.1038/33025 |bibcode=1998Natur.392..442S |s2cid=205002296 |doi-access=free }}
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*{{cite journal | vauthors=Albert ML, Kim JI, Birge RB |title=alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells |journal=Nat. Cell Biol. |volume=2 |issue= 12 |pages= 899–905 |year= 2001 |pmid= 11146654 |doi=10.1038/35046549 |s2cid=7535200 }}
*{{cite journal | vauthors=Albert ML, Kim JI, Birge RB |title=alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells |journal=Nat. Cell Biol. |volume=2 |issue= 12 |pages= 899–905 |year= 2001 |pmid= 11146654 |doi=10.1038/35046549 |s2cid=7535200 }}
*{{cite journal | vauthors=Kobayashi S, Shirai T, Kiyokawa E |title=Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3 |journal=Biochem. J. |volume=354 |issue= Pt 1 |pages= 73–8 |year= 2001 |pmid= 11171081 |doi=10.1042/0264-6021:3540073 | pmc=1221630 |display-authors=etal}}
*{{cite journal | vauthors=Kobayashi S, Shirai T, Kiyokawa E |title=Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3 |journal=Biochem. J. |volume=354 |issue= Pt 1 |pages= 73–8 |year= 2001 |pmid= 11171081 |doi=10.1042/0264-6021:3540073 | pmc=1221630 |display-authors=etal}}
*{{cite journal | vauthors=Tu Y, Kucik DF, Wu C |title=Identification and kinetic analysis of the interaction between Nck-2 and DOCK180 |journal=FEBS Lett. |volume=491 |issue= 3 |pages= 193–9 |year= 2001 |pmid= 11240126 |doi=10.1016/S0014-5793(01)02195-0 |s2cid=31372015 |doi-access=free }}
*{{cite journal | vauthors=Tu Y, Kucik DF, Wu C |title=Identification and kinetic analysis of the interaction between Nck-2 and DOCK180 |journal=FEBS Lett. |volume=491 |issue= 3 |pages= 193–9 |year= 2001 |pmid= 11240126 |doi=10.1016/S0014-5793(01)02195-0 |s2cid=31372015 |doi-access=free |bibcode=2001FEBSL.491..193T }}
*{{cite journal | vauthors=Gu J, Sumida Y, Sanzen N, Sekiguchi K |title=Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 27090–7 |year= 2001 |pmid= 11369773 |doi=10.1074/jbc.M102284200 |doi-access=free }}
*{{cite journal | vauthors=Gu J, Sumida Y, Sanzen N, Sekiguchi K |title=Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 27090–7 |year= 2001 |pmid= 11369773 |doi=10.1074/jbc.M102284200 |doi-access=free }}
*{{cite journal | vauthors=Zhou Z, Caron E, Hartwieg E |title=The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway |journal=Dev. Cell |volume=1 |issue= 4 |pages= 477–89 |year= 2001 |pmid= 11703939 |doi=10.1016/S1534-5807(01)00058-2 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Zhou Z, Caron E, Hartwieg E |title=The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway |journal=Dev. Cell |volume=1 |issue= 4 |pages= 477–89 |year= 2001 |pmid= 11703939 |doi=10.1016/S1534-5807(01)00058-2 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Grimsley CM, Kinchen JM, Tosello-Trampont AC |title=Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 6087–97 |year= 2004 |pmid= 14638695 |doi=10.1074/jbc.M307087200 |s2cid=2324987 |display-authors=etal|url=http://www.zora.uzh.ch/939/1/Grimsley2004V.pdf |doi-access=free }}
*{{cite journal |vauthors=Grimsley CM, Kinchen JM, Tosello-Trampont AC |title=Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration |journal=J. Biol. Chem. |volume=279 |issue=7 |pages=6087–97 |year=2004 |pmid=14638695 |doi=10.1074/jbc.M307087200 |s2cid=2324987 |display-authors=etal |doi-access=free }}
*{{cite journal | vauthors=Wang X, Wu YC, Fadok VA |title=Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12 |journal=Science |volume=302 |issue= 5650 |pages= 1563–6 |year= 2003 |pmid= 14645848 |doi=10.1126/science.1087641 |bibcode=2003Sci...302.1563W |s2cid=25672278 |url=http://ntur.lib.ntu.edu.tw/bitstream/246246/161415/1/06.pdf |display-authors=etal}}
*{{cite journal |vauthors=Wang X, Wu YC, Fadok VA |title=Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12 |journal=Science |volume=302 |issue=5650 |pages=1563–6 |year=2003 |pmid=14645848 |doi=10.1126/science.1087641 |bibcode=2003Sci...302.1563W |s2cid=25672278 |url=http://ntur.lib.ntu.edu.tw/bitstream/246246/161415/1/06.pdf |display-authors=etal }}
{{refend}}
{{refend}}


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* {{PDBe-KB2|Q14185|Dedicator of cytokinesis protein 1}}
* {{PDBe-KB2|Q14185|Dedicator of cytokinesis protein 1}}


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{GTP-binding protein regulators}}
{{GTP-binding protein regulators}}

Latest revision as of 11:38, 15 November 2024

DOCK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 1
External IDsOMIM: 601403; MGI: 2429765; HomoloGene: 55575; GeneCards: DOCK1; OMA:DOCK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

1793

330662

Ensembl

ENSG00000150760

ENSMUSG00000058325

UniProt

Q14185

Q8BUR4

RefSeq (mRNA)

NM_001290223
NM_001380

NM_001033420

RefSeq (protein)

NP_001028592

Location (UCSC)Chr 10: 126.91 – 127.45 MbChr 7: 134.27 – 134.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dedicator of cytokinesis protein 1 (Dock1), also (DOCK180), is a large (~180 kDa) protein encoded in the human by the DOCK1 gene, involved in intracellular signalling networks.[5] It is the mammalian ortholog of the C. elegans protein CED-5 and belongs to the DOCK family of guanine nucleotide exchange factors (GEFs).[6]

Discovery

[edit]

DOCK180 was identified, using a far-western blotting approach, as a binding partner of the adaptor protein Crk that was able to induce morphological changes in 3T3 fibroblasts.[7] Subsequently it was reported that DOCK180 was able to activate the small GTP-binding protein (G protein) Rac1[8] and this was later shown to happen via its ability to act as a GEF.[9]

Structure and function

[edit]

DOCK180 is part of a large class of proteins (GEFs) which contribute to cellular signalling events by activating small G proteins. In their resting state G proteins are bound to Guanosine diphosphate (GDP) and their activation requires the dissociation of GDP and binding of guanosine triphosphate (GTP). GEFs activate G proteins by promoting this nucleotide exchange.

DOCK180 and related proteins differ from other GEFs in that they do not possess the canonical structure of tandem DH-PH domains known to elicit nucleotide exchange. Instead they possess a DHR2 domain which mediates Rac activation by stabilising it in its nucleotide-free state.[9] DOCK180-related proteins also possess a DHR1 domain which has been shown, in vitro, to bind phospholipids[10] and which may be involved in their interaction with cellular membranes. Other structural features of Dock180 include an N-terminal SH3 domain involved in binding to ELMO proteins (see below)[11] and a C-terminal proline-rich region which, in Myoblast city (the Drosophila melanogaster ortholog of DOCK180), was shown to bind DCrk (the Drosophila ortholog of Crk).[12]

Regulation of DOCK180 Activity

[edit]

Under physiological conditions DOCK180 alone is inefficient at promoting nucleotide exchange on Rac.[11] Effective GEF activity requires an interaction between Dock180 and its binding partner ELMO. ELMO1 is the most comprehensively described isoform of this small family of non-catalytically active proteins which function to recruit Dock180 to the plasma membrane and induce conformational changes which increase GEF efficiency.[13][14][15] ELMO1 has also been reported to inhibit ubiquitinylation of Dock180 and so prevent its degradation by proteasomes.[16] Receptor-mediated activation of RhoG (a small G protein of the Rac subfamily) is perhaps the best known inducer of Dock180 GEF activity. Active (GTP-bound) RhoG recruits the ELMO/Dock180 complex to the plasma membrane thereby bringing Dock180 into contact with its substrate, Rac.[17] In tumour cells DOCK180 is regulated by a complex containing Crk and p130Cas which is in turn regulated by cooperative signalling by β3-containing integrin complexes and the membrane-bound protein uPAR.[18]

Signalling Downstream of DOCK180

[edit]

DOCK180 is a Rac-specific GEF and so is responsible for a subset of Rac-specific signalling events. These include cell migration and phagocytosis of apoptotic cells in C. elegans,[19] neurite outgrowth in PC12 cells[20] and myoblast fusion in the zebrafish embryo.[21] More recently the DHR1 domain of DOCK180 was shown to bind SNX5 (a sorting nexin) and this interaction promoted retrograde transport of the cation-independent mannose 6-phosphate receptor to the trans-Golgi network in a Rac-independent manner.[22] Increased expression of DOCK180 and Elmo has been reported to contribute to glioma invasion.[23]

Interactions

[edit]

DOCK180 has been shown to interact with:

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150760 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058325 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: DOCK1 dedicator of cytokinesis 1".
  6. ^ Meller N, Merlot S, Guda C (November 2005). "CZH proteins: a new family of Rho-GEFs". J. Cell Sci. 118 (Pt 21): 4937–46. doi:10.1242/jcs.02671. PMID 16254241. S2CID 3075895.
  7. ^ Hasegawa H, Kiyokawa E, Tanaka S, et al. (April 1996). "DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane". Mol. Cell. Biol. 16 (4): 1770–76. doi:10.1128/mcb.16.4.1770. PMC 231163. PMID 8657152.
  8. ^ Kiyokawa E, Hashimoto Y, Kobayashi S, et al. (November 1998). "Activation of Rac1 by a Crk SH3-binding protein, DOCK180". Genes Dev. 12 (21): 3331–36. doi:10.1101/gad.12.21.3331. PMC 317231. PMID 9808620.
  9. ^ a b Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell Sci. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077. S2CID 14669715.
  10. ^ Côté JF, Motoyama AB, Bush JA, et al. (August 2005). "A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signaling". Nat. Cell Biol. 7 (8): 797–807. doi:10.1038/ncb1280. PMC 1352170. PMID 16025104.
  11. ^ a b Brugnera E, Haney L, Grimsley C, et al. (August 2002). "Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex". Nat. Cell Biol. 4 (8): 574–82. doi:10.1038/ncb824. PMID 12134158. S2CID 36363774.
  12. ^ Balagopalan L, Chen MH, Geisbrecht ER, et al. (December 2006). "The CDM Superfamily Protein MBC Directs Myoblast Fusion through a Mechanism That Requires Phosphatidylinositol 3,4,5-Triphosphate Binding but Is Independent of Direct Interaction with DCrk". Mol. Cell. Biol. 26 (24): 9442–55. doi:10.1128/MCB.00016-06. PMC 1698515. PMID 17030600.
  13. ^ Lu M, Ravichandran KS (2006). "Dock180–ELMO Cooperation in Rac Activation". Regulators and Effectors of Small GTPases: Rho Family. Methods in Enzymology. Vol. 406. pp. 388–402. doi:10.1016/S0076-6879(06)06028-9. ISBN 978-0-12-182811-0. PMID 16472672.
  14. ^ Lu M, Kinchen JM, Rossman KL, et al. (2004). "PH domain of ELMO functions in trans to regulate Rac activation via Dock180". Nature Structural & Molecular Biology. 11 (8): 756–62. doi:10.1038/nsmb800. PMID 15247908. S2CID 125990.
  15. ^ Lu M, Kinchen JM, Rossman KL, et al. (February 2005). "A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs". Curr. Biol. 15 (4): 371–77. Bibcode:2005CBio...15..371L. doi:10.1016/j.cub.2005.01.050. PMID 15723800. S2CID 14267018.
  16. ^ Makino Y, Tsuda M, Ichihara S, et al. (March 2006). "Elmo1 inhibits ubiquitylation of Dock180". J. Cell Sci. 119 (Pt 5): 923–32. doi:10.1242/jcs.02797. PMID 16495483. S2CID 15035869.
  17. ^ Katoh H, Negishi M (July 2003). "RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo". Nature. 424 (6947): 461–64. Bibcode:2003Natur.424..461K. doi:10.1038/nature01817. PMID 12879077. S2CID 4411133.
  18. ^ Smith HW, Marra P, Marshall CJ (August 2008). "uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180". J. Cell Biol. 182 (4): 777–90. doi:10.1083/jcb.200712050. PMC 2518715. PMID 18725541.
  19. ^ Gumienny TL, Brugnera E, Tosello-Trampont AC, et al. (October 2001). "CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration" (PDF). Cell. 107 (1): 27–41. doi:10.1016/S0092-8674(01)00520-7. PMID 11595183. S2CID 15232864. Archived from the original (PDF) on 2021-09-22. Retrieved 2020-09-13.
  20. ^ Katoh H, Yasui H, Yamaguchi Y, et al. (October 2000). "Small GTPase RhoG Is a Key Regulator for Neurite Outgrowth in PC12 Cells". Mol. Cell. Biol. 20 (19): 7378–87. doi:10.1128/MCB.20.19.7378-7387.2000. PMC 86291. PMID 10982854.
  21. ^ Moore CA, Parkin CA, Bidet Y, et al. (September 2007). "A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion". Development. 134 (17): 3145–53. doi:10.1242/dev.001214. PMID 17670792.
  22. ^ Hara S, Kiyokawa E, Iemura SI, et al. (July 2008). "The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport". Mol. Biol. Cell. 19 (9): 3823–35. doi:10.1091/mbc.E08-03-0314. PMC 2526700. PMID 18596235.
  23. ^ Jarzynka MJ, Hu B, Hui KM, et al. (August 2007). "ELMO1 and Dock180, a Bipartite Rac1 Guanine Nucleotide Exchange Factor, Promote Human Glioma Cell Invasion". Cancer Res. 67 (15): 7203–11. doi:10.1158/0008-5472.CAN-07-0473. PMC 2867339. PMID 17671188.
  24. ^ a b c Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD (Mar 2003). "Differential regulation of cell motility and invasion by FAK". J. Cell Biol. 160 (5): 753–67. doi:10.1083/jcb.200212114. PMC 2173366. PMID 12615911.
  25. ^ a b Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M (Apr 1996). "DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane". Mol. Cell. Biol. 16 (4): 1770–6. doi:10.1128/MCB.16.4.1770. PMC 231163. PMID 8657152.
  26. ^ Nishihara H, Kobayashi S, Hashimoto Y, Ohba F, Mochizuki N, Kurata T, Nagashima K, Matsuda M (Nov 1999). "Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins". Biochim. Biophys. Acta. 1452 (2): 179–87. doi:10.1016/s0167-4889(99)00133-0. PMID 10559471.
  27. ^ Gu J, Sumida Y, Sanzen N, Sekiguchi K (Jul 2001). "Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway". J. Biol. Chem. 276 (29): 27090–7. doi:10.1074/jbc.M102284200. PMID 11369773.
  28. ^ Matsuda M, Ota S, Tanimura R, Nakamura H, Matuoka K, Takenawa T, Nagashima K, Kurata T (Jun 1996). "Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins". J. Biol. Chem. 271 (24): 14468–72. doi:10.1074/jbc.271.24.14468. PMID 8662907.
  29. ^ Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS (Oct 2001). "CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration" (PDF). Cell. 107 (1): 27–41. doi:10.1016/s0092-8674(01)00520-7. PMID 11595183. S2CID 15232864. Archived from the original (PDF) on 2021-09-22. Retrieved 2020-09-13.
  30. ^ Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, Macara IG, Madhani H, Fink GR, Ravichandran KS (Aug 2002). "Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex". Nat. Cell Biol. 4 (8): 574–82. doi:10.1038/ncb824. PMID 12134158. S2CID 36363774.

Further reading

[edit]
[edit]
Retrieved from "https://en.wikipedia.org/enwiki/w/index.php?title=Dedicator_of_cytokinesis_protein_1&oldid=1257529913"