Jump to content

Miltenyi Biotec: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous edit
Content deleted Content added
VisualWikitext
Citation bot (talk | contribs)
Bots
5,370,471 edits
Alter: url, template type. URLs might have been anonymized. Add: date, pmid, doi, page, volume, journal, pmc, year, authors 1-27. Removed proxy/dead URL that duplicated identifier. | Use this bot. Report bugs. | Suggested by Headbomb | #UCB_toolbar
No edit summary
 
(14 intermediate revisions by 11 users not shown)
Line 1: Line 1:
{{Short description|Global biotechnology company}}
{{advert|date=March 2018}}
{{advert|date=March 2018}}
{{Infobox company
{{Infobox company
Line 37: Line 38:
| net_income =
| net_income =
| owner =
| owner =
| num_employees = ~3,000
| num_employees = ~5,500
| parent =
| parent =
| divisions =
| divisions =
Line 47: Line 48:
}}
}}


'''Miltenyi Biotec''' is a global [[biotechnology]] company headquartered near Cologne in [[Bergisch Gladbach]], Germany. The company is a provider of products and services that support scientists, clinical researchers, and physicians across basic research, [[translational research]], and clinical applications. The company offers solutions{{buzzword inline|date=September 2019}} covering techniques of sample preparation, [[Cell (biology)|cell]] separation, cell sorting, [[flow cytometry]], [[cell culture]], [[molecular]] analysis, [[clinical research|clinical]] applications and [[small animal imaging]]. Miltenyi Biotec has more than 3,000 employees in 28 countries and more than 17,000 products.{{citation needed|date=September 2019}}
'''Miltenyi Biotec''' is a global [[biotechnology]] company headquartered near Cologne in [[Bergisch Gladbach]], Germany. The company is a provider of products and services for scientists, clinical researchers, and physicians to use in their basic research, [[translational research]], and clinical applications. These services include techniques of sample preparation, [[Cell (biology)|cell]] separation, cell sorting, [[flow cytometry]], spatial biology, [[cell culture]], [[molecular]] analysis, [[clinical research|clinical]] applications and [[small animal imaging]]. According to Miltenyi Biotec own internal sources, the company states that it has over 3,000 employees in 28 countries and produces more than 17,000 products although this has not been independently verified.{{citation needed|date=September 2019}}


==Products==
==Products==
Miltenyi Biotec products have been cited in more than 20,000 publications and used in more than 35.000 clinical treatments to date. Many of the publications that have cited Miltenyi Biotec products can be accessed through [[CiteAb]], an antibody search engine which lists 4591 Miltenyi Biotec products.<ref>{{cite web|title=Browse antibodies by Miltenyi Biotec|url=http://www.citeab.com/browse/suppliers/miltenyi-biotec|work=CiteAb|accessdate=11 September 2014|archive-date=11 September 2014|archive-url=https://web.archive.org/web/20140911214912/http://www.citeab.com/browse/suppliers/miltenyi-biotec|url-status=dead}}</ref> Miltenyi Biotec instruments, [[reagents]] and services support basic research, clinical research, and the translation of basic research findings into clinical applications that enhance human health and treat severe disease. Its product portfolio addresses a complete range of techniques from bench to bedside. Services offered by Miltenyi Biotec include gene expression analysis <ref>{{Cite web|title=Key Features in the Latest Flow Cytometry Systems, Caitlin Smith, Biocompare|url=http://www.biocompare.com/Editorial-Articles/41797-Key-Features-in-the-Latest-Flow-Cytometry-Systems/|access-date=2013-01-14|archive-date=2019-04-02|archive-url=https://web.archive.org/web/20190402131602/https://www.biocompare.com/Editorial-Articles/41797-Key-Features-in-the-Latest-Flow-Cytometry-Systems/|url-status=dead}}</ref> and contract production of biologicals according to GMP guidelines.
Miltenyi Biotec states that their products have been cited in publications and used in clinical treatments although details on figures has not been independently verified. However, publications that have cited Miltenyi Biotec products can be accessed through [[CiteAb]], an antibody search engine which lists 4591 Miltenyi Biotec products.<ref>{{cite web|title=Browse antibodies by Miltenyi Biotec|url=http://www.citeab.com/browse/suppliers/miltenyi-biotec|work=CiteAb|accessdate=11 September 2014|archive-date=11 September 2014|archive-url=https://web.archive.org/web/20140911214912/http://www.citeab.com/browse/suppliers/miltenyi-biotec|url-status=dead}}</ref>
Miltenyi Biotec instruments, [[reagents]] and services are intended support basic research, clinical research, and the translation of basic research findings into clinical applications that aims to treat severe diseases. Services offered by Miltenyi Biotec include gene expression analysis <ref>{{Cite web|title=Key Features in the Latest Flow Cytometry Systems, Caitlin Smith, Biocompare|url=http://www.biocompare.com/Editorial-Articles/41797-Key-Features-in-the-Latest-Flow-Cytometry-Systems/|access-date=2013-01-14|archive-date=2019-04-02|archive-url=https://web.archive.org/web/20190402131602/https://www.biocompare.com/Editorial-Articles/41797-Key-Features-in-the-Latest-Flow-Cytometry-Systems/|url-status=dead}}</ref> and contract production of biologicals according to GMP guidelines.


Miltenyi Biotec technologies are used in applications concerned with accessing, analyzing, and utilizing primary and primary-derived cells – across basic research, translational research, and clinical applications.<ref>{{Cite web|title=Official website|url=http://www.miltenyibiotec.com/en/NN_404_Company.aspx|access-date=2013-01-14|archive-url=https://web.archive.org/web/20120915064709/http://miltenyibiotec.com/en/NN_404_Company.aspx|archive-date=2012-09-15|url-status=dead}}</ref> Examples of these applications include sample preparation, cell separation, cell sorting, flow cytometry, molecular applications, cell culture up to GMP grade, preclinical imaging, clinical-grade cell preservation, and clinical-scale cell processing. The company’s reagents and devices are used primarily in the research areas of [[immunology]], [[stem cell]] biology, [[neuroscience]] and [[cancer]].<ref>{{Cite web|title=Small But Mighty, Andreas Gruetzkau|url=https://www.researchgate.net/publication/44804986}}</ref>
Miltenyi Biotec technologies are used in applications concerned with accessing, analyzing, and utilizing primary and primary-derived cells – across basic research, translational research, and clinical applications.<ref>{{Cite web|title=Official website|url=http://www.miltenyibiotec.com/en/NN_404_Company.aspx|access-date=2013-01-14|archive-url=https://web.archive.org/web/20120915064709/http://miltenyibiotec.com/en/NN_404_Company.aspx|archive-date=2012-09-15|url-status=dead}}</ref> Examples of these applications include sample preparation, cell separation, cell sorting, flow cytometry, molecular applications, cell culture up to GMP grade, preclinical imaging, clinical-grade cell preservation, and clinical-scale cell processing. The company’s reagents and devices are used primarily in the research areas of [[immunology]], [[stem cell]] biology, [[neuroscience]] and [[cancer]].<ref>{{Cite web|title=Small But Mighty, Andreas Gruetzkau|url=https://www.researchgate.net/publication/44804986}}</ref>
Line 58: Line 61:


==Application areas==
==Application areas==
{{Unreferenced section|date=June 2024}}
Miltenyi Biotec products are used commonly in the application areas of immunology, stem cell biology, neuroscience and cancer. Their products are used from basic research to clinical applications and are designed to support the successful translation of findings into practical applications that enhance human health and well being. Enabling translational research is a major mission of the company, as is advancing cellular therapy. The company’s products aim to support the development of cellular therapies and make cellular therapy a more viable reality for more patients.
Miltenyi Biotec products are used commonly in the application areas of immunology, stem cell biology, neuroscience and cancer. Their products are used from basic research to clinical applications and are designed to support the successful translation of findings into practical applications that enhance human health and well being. Enabling translational research is a major mission of the company, as is advancing cellular therapy. The company’s products aim to support the development of cellular therapies and make cellular therapy a more viable reality for more patients.


Line 87: Line 91:


==Structure==
==Structure==
{{Unreferenced section|date=June 2024}}
Miltenyi Biotec is a limited liability company (referred to as [[GmbH]] in Germany). The officers of the company are Stefan Miltenyi (Founder and President), Dr. Boris Stoffel, Norbert Hentschel, Dr. Juergen Schmitz, Dr. Anoon Overstijns. Headquartered in Bergisch Gladbach with a [[Good manufacturing practice|GMP]] facility in Teterow, Germany, Miltenyi Biotec also has locations in the United States (two GMP facilities), Great Britain, France, Belgium, Italy, Spain, China, Australia, Japan, The Netherlands, Singapore and Sweden.
Miltenyi Biotec is a limited liability company (referred to as [[GmbH]] in Germany). The officers of the company are Stefan Miltenyi (Founder and President), Dr. Boris Stoffel, Norbert Hentschel, Dr. Juergen Schmitz, Dr. Anoon Overstijns. Headquartered in Bergisch Gladbach with a [[Good manufacturing practice|GMP]] facility in Teterow, Germany, Miltenyi Biotec also has locations in the United States (two GMP facilities), Great Britain, France, Belgium, Italy, Spain, China, Australia, Japan, The Netherlands, Singapore and Sweden.


Line 92: Line 97:


The North American Divisions are supported by Miltenyi Biotec North America, which provides all central services to the North American Divisions.
The North American Divisions are supported by Miltenyi Biotec North America, which provides all central services to the North American Divisions.

==Controversies==
In March 2022, citing [[2022 Russian Invasion of Ukraine|Russian Invasion of Ukraine]] as the reason,<ref>{{Cite web|title=BioCentury.com|url=https://www.biocentury.com/article/643564/russia-boycott-includes-car-t-therapies}}</ref><ref name="iStories">{{Cite web|title=iStories|url=https://istories-media.translate.goog/opinions/2022/06/10/oni-umrut/?_x_tr_sl=ru&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp|quote=Therefore, right now, according to Important Stories, about 50 children with blood cancer - patients of the Rogachev Center - are doomed to die. “There are no alternative supplies and there will not be. This technology was provided by a single manufacturer. Some companies are working in the same direction, but so far there is nothing close, ” said Alexei Maschan, director of the Institute of Hematology, Immunology and Cell Technologies of the National Medical Research Center, to Vademecum. “The refusal of Miltenyi Biotec to supply consumables for patients means one thing - they will die.}}</ref> Miltenyi Biotec suspended supplies of CAR-T therapy equipment to Russian Rogachev children's hospital, leaving patients with incurable tumors for which all other possibilities have been exhausted with no treatment options.<ref>{{Cite web|title=BioCentury.com|url=https://www.biocentury.com/article/643564/russia-boycott-includes-car-t-therapies| quote= "The voluntary boycott will leave Russian children who would have received CAR-T cancer therapy with no options, unless they can travel to another country." }}</ref><ref name="iStories" / ></ref> According to {{ill|Alexei Maschan|ru|Масчан, Алексей Александрович}}, director of the Institute of Hematology, Immunology and Cell Technologies of the National Medical Research Center, it will lead to their death.<ref>{{Cite web|title=Russia Matters|url=https://www.russiamatters.org/news/russia-review/russia-review-june-3-10-2022| quote=Therefore, right now about 50 children with blood cancer—patients of the Rogachev Institute—are doomed to die.}}</ref><ref name="iStories" / ></ref> While the treatment was available, 90% of child patients were achieving remission, with at least 54 lives saved since 2018.<ref>{{Cite journal|title=U.S. National Institutes of Health's National Library of Medicine (NIH/NLM) |year= 2021|pmc= 8664838|last1= Maschan|first1= M.|last2= Caimi|first2= P. F.|last3= Reese-Koc|first3= J.|last4= Sanchez|first4= G. P.|last5= Sharma|first5= A. A.|last6= Molostova|first6= O.|last7= Shelikhova|first7= L.|last8= Pershin|first8= D.|last9= Stepanov|first9= A.|last10= Muzalevskii|first10= Y.|last11= Suzart|first11= V. G.|last12= Otegbeye|first12= F.|last13= Wald|first13= D.|last14= Xiong|first14= Y.|last15= Wu|first15= D.|last16= Knight|first16= A.|last17= Oparaocha|first17= I.|last18= Ferencz|first18= B.|last19= Roy|first19= A.|last20= Worden|first20= A.|last21= Kruger|first21= W.|last22= Kadan|first22= M.|last23= Schneider|first23= D.|last24= Orentas|first24= R.|last25= Sekaly|first25= R. P.|last26= De Lima|first26= M.|last27= Dropulić|first27= B.|journal= Nature Communications|volume= 12|page= 7200|doi= 10.1038/s41467-021-27312-6|pmid= 34893603}}</ref><ref>{{Cite web|title=Kommersant| date=31 March 2022 |url= https://www-kommersant-ru.translate.goog/doc/5283357?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp| quote=The therapy is carried out in an experimental format: it is prescribed by the decision of the medical council to patients with incurable forms of the tumor, when all possibilities have been exhausted. By August 2021, the NMIC had treated more than 60 patients, 90% of them were in remission, Mikhail Maschan, deputy director general of the Institute of Molecular and Experimental Medicine of the Rogachev Center, previously reported to Vademecum. On Wednesday, the NMIC did not respond to Kommersant's request. A Kommersant source close to the center confirmed that Miltenyi Biotec had suspended supplies, and the available material remained for the treatment of three to four patients. }}</ref><ref>{{Cite web|title=Pharmvestnik|url= https://pharmvestnik-ru.translate.goog/content/news/Miltenyi-Biotec-priostanovila-postavki-oborudovaniya-dlya-CAR-T-terapii-v-Rossiu.html?_x_tr_sl=ru&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp}}</ref><ref>{{Cite web|title=Gazeta.ru|url= https://www-gazeta-ru.translate.goog/social/news/2022/03/31/17502541.shtml?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp}}</ref><ref>{{Cite web|title=Izvestiya |date= 31 March 2022|url= https://iz.ru/1313307/2022-03-31/miltenyi-biotec-prekratila-postavki-oborudovaniia-dlia-onkoterapii-v-rf| language=ru}}</ref><ref>{{Cite web|title=RBC|url= https://www-rbc-ru.translate.goog/society/31/03/2022/62453c589a7947ab30614863?_x_tr_sl=ru&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp}}</ref>


==References==
==References==

Latest revision as of 12:52, 21 November 2024

Miltenyi Biotec
Company typePrivate
IndustryBiotechnology
Founded1989; 35 years ago (1989)
FounderStefan Miltenyi
Headquarters
Bergisch Gladbach, North Rhine-Westphalia
,
Germany
Key people
Stefan Miltenyi, Founder & President

Dr. Boris Stoffel,
Norbert Hentschel,
Dr. Jürgen Schmitz,

Dr. Antoon Overstijns
ProductsMACS Sample Preparation

gentleMACS Dissociators
MACS Cell Separation
autoMACS Pro Separator
MACS Flow Cytometry
MACSQuant Analyzers
MACS Antibodies
MACSmolecular
CliniMACS System
MACS Cell Culture
MACS Media
MACS Cytokines
TheraSorb

Viscover Imaging Agents
Number of employees
~5,500
Websitewww.miltenyibiotec.com

Miltenyi Biotec is a global biotechnology company headquartered near Cologne in Bergisch Gladbach, Germany. The company is a provider of products and services for scientists, clinical researchers, and physicians to use in their basic research, translational research, and clinical applications. These services include techniques of sample preparation, cell separation, cell sorting, flow cytometry, spatial biology, cell culture, molecular analysis, clinical applications and small animal imaging. According to Miltenyi Biotec own internal sources, the company states that it has over 3,000 employees in 28 countries and produces more than 17,000 products although this has not been independently verified.[citation needed]

Products

[edit]

Miltenyi Biotec states that their products have been cited in publications and used in clinical treatments although details on figures has not been independently verified. However, publications that have cited Miltenyi Biotec products can be accessed through CiteAb, an antibody search engine which lists 4591 Miltenyi Biotec products.[1]

Miltenyi Biotec instruments, reagents and services are intended support basic research, clinical research, and the translation of basic research findings into clinical applications that aims to treat severe diseases. Services offered by Miltenyi Biotec include gene expression analysis [2] and contract production of biologicals according to GMP guidelines.

Miltenyi Biotec technologies are used in applications concerned with accessing, analyzing, and utilizing primary and primary-derived cells – across basic research, translational research, and clinical applications.[3] Examples of these applications include sample preparation, cell separation, cell sorting, flow cytometry, molecular applications, cell culture up to GMP grade, preclinical imaging, clinical-grade cell preservation, and clinical-scale cell processing. The company’s reagents and devices are used primarily in the research areas of immunology, stem cell biology, neuroscience and cancer.[4]

Sample Preparation

[edit]

Miltenyi Biotec offers instruments, tools and reagents to facilitate sample preparation.

Application areas

[edit]

Miltenyi Biotec products are used commonly in the application areas of immunology, stem cell biology, neuroscience and cancer. Their products are used from basic research to clinical applications and are designed to support the successful translation of findings into practical applications that enhance human health and well being. Enabling translational research is a major mission of the company, as is advancing cellular therapy. The company’s products aim to support the development of cellular therapies and make cellular therapy a more viable reality for more patients.

History

[edit]
  • 1989 – Stefan Miltenyi invents magnetic-activated cell separation
  • 1990 – Miltenyi Biotec patents MACS Technology
  • 1992 – Miltenyi Biotec opens its U.S. subsidiary
  • 1995 – Miltenyi Biotec opens its UK subsidiary
  • 1998 – Miltenyi Biotec opens its France, Italy and Spain subsidiaries
  • 2001 – Miltenyi Biotec opens its China location
  • 2002 – Miltenyi Biotec acquires the plasma absorber technology developed by PlasmaSelect AG and markets the products under the trademark TheraSorb
  • 2002 – Miltenyi Biotec opens its Australia subsidiary
  • 2003 – Miltenyi Biotec opens its GMP facility in Teterow, Germany
  • 2003 – Miltenyi Biotec opens its Japan and Singapore subsidiaries
  • 2003 – Miltenyi Biotec acquires Memorec Biotec GmbH
  • 2004 – Miltenyi Biotec opens its Benelux subsidiary in the Netherlands
  • 2008 – Miltenyi Biotec acquires Medic Tools AG [5]
  • 2008 – Miltenyi Biotec launches its autoMACS Pro Separator cell separation instrument
  • 2008 – Miltenyi Biotec launches its MACSQuant Analyzer flow cytometry instrument
  • 2011 – Miltenyi Biotec acquires Coley Pharmaceutical Group
  • 2011 – Miltenyi Biotec partners with TeutoCell to develop novel cell culture techniques [6]
  • 2012 – Miltenyi Biotec opens its Nordic subsidiary in Sweden
  • 2012 – Miltenyi Biotec opens its Korea subsidiary in Seoul, South Korea
  • 2013 – Miltenyi Biotec acquires Owl biomedical, adding to their portfolio new microchip-based cell sorting technology
  • 2014 – Miltenyi Biotec receives FDA approval for CliniMACS® CD34 Reagent System for prevention of graft-versus-host disease in the treatment of acute myeloid leukemia
  • 2014 – Miltenyi Biotec acquires gene therapy assets from Lentigen Corporation
  • 2017 – Acquisition of imaging specialist Sensovation AG
  • 2018 – Acquisition of microscopy specialist LaVision BioTec

Structure

[edit]

Miltenyi Biotec is a limited liability company (referred to as GmbH in Germany). The officers of the company are Stefan Miltenyi (Founder and President), Dr. Boris Stoffel, Norbert Hentschel, Dr. Juergen Schmitz, Dr. Anoon Overstijns. Headquartered in Bergisch Gladbach with a GMP facility in Teterow, Germany, Miltenyi Biotec also has locations in the United States (two GMP facilities), Great Britain, France, Belgium, Italy, Spain, China, Australia, Japan, The Netherlands, Singapore and Sweden.

The company has more than 3,500 employees worldwide (approx. 800 in the United States).

The North American Divisions are supported by Miltenyi Biotec North America, which provides all central services to the North American Divisions.

References

[edit]
  1. ^ "Browse antibodies by Miltenyi Biotec". CiteAb. Archived from the original on 11 September 2014. Retrieved 11 September 2014.
  2. ^ "Key Features in the Latest Flow Cytometry Systems, Caitlin Smith, Biocompare". Archived from the original on 2019-04-02. Retrieved 2013-01-14.
  3. ^ "Official website". Archived from the original on 2012-09-15. Retrieved 2013-01-14.
  4. ^ "Small But Mighty, Andreas Gruetzkau".
  5. ^ "PR Newswire". Archived from the original on 2016-03-04. Retrieved 2013-01-14.
  6. ^ "Life Sciences Germany, Stefan Northoff". Archived from the original on 2018-12-15. Retrieved 2013-01-14.
Retrieved from "https://en.wikipedia.org/enwiki/w/index.php?title=Miltenyi_Biotec&oldid=1258754774"