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{{Short description|Dutch mass spectrometry researcher}}
{{AfC submission|t||ts=20201218114308|u=Hnguyen editor|ns=118|demo=}}
{{Infobox scientist/sandbox
{{Infobox scientist
| name = Ron M.A. Heeren
| name = Ron M.A. Heeren
| image =
| image = Ron Heeren.jpg
| caption = Ron Heeren in 2017
| birth_date = 1965
| birth_date = 1965
| birth_place = Tilburg, Netherlands
| birth_place = Tilburg, Netherlands
| nationality = Dutch
| nationality = Dutch
| fields = Imaging Mass Spectrometry, Analytical Chemistry, Biomolecular Imaging, Nanoscale Chemical Imaging
| fields = Imaging Mass Spectrometry
| alma_mater = University of Amsterdam
| alma_mater = University of Amsterdam
| awards = Hans Fisher Fellowship; Thomson Medal of IMSF; NWO-Physics Valorisation Prize; Brightlands Convention Award; Robert Feulgen lecturer, Society for Histochemistry; Award, Exploratory Measurement Science Group (EMSG), University of Edinburgh; Distinguished Wiley Visiting Scientist award; RCM Beynon Prize, Rapid Communications in Mass Spectrometry; Bert L. Schram Award, Dutch Society for Mass Spectrometry (NVMS)
| awards = Hans Fisher Fellowship; Thomson Medal of IMSF; NWO-Physics Valorisation Prize; Brightlands Convention Award; Robert Feulgen lecturer, Society for Histochemistry; Distinguished Wiley Visiting Scientist award;
}}
}}<!-- Important, do not remove this line before article has been created. -->


Ron M.A. Heeren (1965, [[Tilburg]]) is a Dutch scientist in [[mass spectrometry imaging]]. He is currently a distinguished professor at [[Maastricht University]] and the scientific director of the [https://www.maastrichtuniversity.nl/research/maastricht-multimodal-molecular-imaging-institute Multimodal Molecular Imaging Institute (M4I)], where he heads the division of [https://www.maastrichtuniversity.nl/research/m4i-division-imaging-mass-spectrometry Imaging Mass Spectrometry].
'''Ron M.A. Heeren''' (born 1965, [[Tilburg]]) is a Dutch scientist in [[mass spectrometry imaging]]. He is currently a distinguished professor at [[Maastricht University]] and the scientific director of the Multimodal Molecular Imaging Institute (M4I), where he heads the division of Imaging Mass Spectrometry.


== Scientific career ==
== Scientific career ==
Ron Heeren obtained a PhD degree in Technical Physics at the [[University of Amsterdam]] in 1992 under the supervision of Aart Kleyn. He led a [[AMOLF|FOM-AMOLF]] research group focusing on macromolecular ion physics and biomolecular imaging mass spectrometry (1995–2014). He was also appointed as [https://profs.library.uu.nl/index.php/profrec/getprofdata/824/20/50/0 professor at the chemistry faculty of Utrecht University] in 2001–2019.
Heeren obtained a PhD degree in Technical Physics at the [[University of Amsterdam]] in 1992 under the supervision of Aart Kleyn.


He led a [[AMOLF|FOM-AMOLF]] research group on macromolecular ion physics and biomolecular imaging mass spectrometry (1995–2014). He was also professor at the chemistry faculty of [[Utrecht University]] in 2001–2019.
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Between 1995 and 2015, he developed new approaches towards high spatial resolution and high-throughput molecular imaging mass spectrometry using [[secondary ion mass spectrometry]] (SIMS) and [[Matrix-assisted laser desorption/ionization|matrix-assisted laser desorption and ionization]] (MALDI).


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Between 1995 and 2015, he worked on new approaches towards high spatial resolution and high-throughput molecular imaging mass spectrometry using [[secondary ion mass spectrometry]] (SIMS) and [[Matrix-assisted laser desorption/ionization|matrix-assisted laser desorption and ionization]] (MALDI).
From 2008 to 2013, Heeren was the research director for emerging technologies at the [[Netherlands Proteomics Centre]]. In 2012, he co-founded Omics2Image B.V., a company focused on bringing innovative ion detector technology to the analytical market. In 2014, he was appointed to his current position as one of the scientific directors of M4I at Maastricht University.<ref>{{Cite web|title=Maastricht University Magazine October 2014|url=https://issuu.com/maastrichtuniversity/docs/mum_oktober_14|access-date=2020-12-18|website=Issuu|language=en}}</ref>


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Heeren has coauthored over 300 peer-reviewed articles, which have been cited over 12,600 times (Google Scholar).<ref>{{Cite web|title=Ron M.A. Heeren|url=https://scholar.google.nl/citations?user=PL9UftUAAAAJ&hl=nl|access-date=2020-12-18|website=scholar.google.nl}}</ref>
Heeren is an active member in numerous professional societies related to his field, including Dutch Physics Society (1993), The American Chemical Society (2010), and [https://www.asms.org/ The American Society for Mass Spectrometry] (1994). Heeren was president of the [https://www.nvms.nl/ Dutch Society of Mass Spectrometry] between 2001–2005<ref>{{Cite web|title=History|url=https://www.nvms.nl/index.php/historie/|access-date=2020-12-18|website=NVMS|language=en-US}}</ref>. He is one of the founding members of the [https://ms-imaging.org/wp/mass-spectrometry-imaging-society/ Mass Spectrometry Imaging Society], and was elected its president in 2017.<ref>{{Cite web|title=Mass Spectrometry Imaging Society – MS Imaging|url=https://ms-imaging.org/wp/mass-spectrometry-imaging-society/|access-date=2020-12-18|website=ms-imaging.org}}</ref> For his “contributions to the mass spectrometry internationally” over his 30-year career, Heeren was awarded the Thomson Medal by the [[International Mass Spectrometry Society]].<ref>{{Cite web|last=Maastricht|first=Minderbroedersberg 4-6 6211 LK|title=Thomson Medal 2020 awarded to Ron Heeren|url=https://www.maastrichtuniversity.nl/news/thomson-medal-2020-awarded-ron-heeren|access-date=2020-12-18|website=www.maastrichtuniversity.nl|language=en}}</ref>

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Heeren has coauthored over 300 peer-reviewed articles, which have been cited over 12,600 times (Google Scholar; h index = 58).<ref>{{Cite web|title=Ron M.A. Heeren|url=https://scholar.google.nl/citations?user=PL9UftUAAAAJ&hl=nl|access-date=2020-12-18|website=scholar.google.nl}}</ref>

== Valorization ==
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Heeren has translated his innovations and scientific findings to patented techniques and instruments throughout his career. To date, he holds 7 patents and has established two spin-off companies, [https://www.amscins.com/ Omics2Image/ASI] and the [https://www.hairdiagnostix.nl/ Dutch Screening Group]. In 2019, Heeren was awarded the NWO Valorisation Prize in Physics<ref>{{Cite web|title=NWO Physics Valorisation Prize 2019 - Ron Heeren - YouTube|url=https://www.youtube.com/watch?v=fCa7VtLT2r4|access-date=2020-12-18|website=www.youtube.com}}</ref> given to a “researcher [who] has managed to turn the results of their own research into something useful for society."<ref>{{Cite web|title=NWO Physics Valorisation Prize goes to Ron Heeren from Maastricht University {{!}} NWO|url=https://www.nwo.nl/en/news/nwo-physics-valorisation-prize-goes-ron-heeren-maastricht-university|access-date=2020-12-18|website=www.nwo.nl|language=en}}</ref>


== Research ==
== Research ==
Heeren’s academic research interests are the fundamental studies of the energetics of macromolecular systems, conformational studies of non-covalently bound protein complexes, translational imaging research, high-throughput bioinformatics, and the development and validation of new mass spectrometry–based proteomic imaging techniques for the life sciences.
Heeren’s academic research interests are fundamental studies of the energetics of macromolecular systems, conformational studies of non-covalently bound protein complexes, translational imaging research, high-throughput bioinformatics, and the development and validation of new mass spectrometry–based proteomic imaging techniques for the life sciences.


During his postdoctoral fellowship, he worked on the development of innovative ion sources, vacuums systems, data acquisition systems and novel temperature-controlled ion cyclotron resonance cells. He used the FTICR-MS instrument for the study of collisional energy transfer and internal energy distributions.<ref>{{Cite journal|last=Heeren|first=Ron M. A.|last2=Vékey|first2=Károly|date=1998-09-15|title=A novel method to determine collisional energy transfer efficiency by Fourier transform ion cyclotron resonance mass spectrometry|url=http://dx.doi.org/10.1002/(sici)1097-0231(19980915)12:17<1175::aid-rcm305>3.0.co;2-l|journal=Rapid Communications in Mass Spectrometry|volume=12|issue=17|pages=1175–1181|doi=10.1002/(sici)1097-0231(19980915)12:17<1175::aid-rcm305>3.0.co;2-l|issn=0951-4198}}</ref><ref>{{Cite journal|last=Drahos|first=null|last2=Heeren|first2=null|last3=Collette|first3=null|last4=De Pauw E|first4=null|last5=Vekey|first5=null|date=December 1999|title=Thermal energy distribution observed in electrospray ionization|url=https://pubmed.ncbi.nlm.nih.gov/10587635/|journal=Journal of mass spectrometry: JMS|volume=34|issue=12|pages=1373–1379|doi=10.1002/(SICI)1096-9888(199912)34:123.0.CO;2-#|issn=1096-9888|pmid=10587635}}</ref><ref>{{Cite journal|last=Guo|first=Xinghua|last2=Duursma|first2=Marc C.|last3=Kistemaker|first3=Piet G.|last4=Nibbering|first4=Nico M. M.|last5=Vekey|first5=Karoly|last6=Drahos|first6=Laszlo|last7=Heeren|first7=Ron M. A.|date=June 2003|title=Manipulating internal energy of protonated biomolecules in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry|url=https://pubmed.ncbi.nlm.nih.gov/12827629/|journal=Journal of mass spectrometry: JMS|volume=38|issue=6|pages=597–606|doi=10.1002/jms.480|issn=1076-5174|pmid=12827629}}</ref> These methods were deployed to investigate their role in the determination of dissociation pathways of biomolecular systems.<ref>{{Cite journal|last=Koster|first=Sander|last2=Duursma|first2=Marc C.|last3=Boon|first3=Jaap J.|last4=Nielen|first4=Michel W. F.|last5=de Koster|first5=Chris G.|last6=Heeren|first6=Ron M. A.|date=2000|title=Structural analysis of synthetic homo- and copolyesters by electrospray ionization on a Fourier transform ion cyclotron resonance mass spectrometer|url=http://dx.doi.org/10.1002/1096-9888(200006)35:6<739::aid-jms3>3.0.co;2-#|journal=Journal of Mass Spectrometry|volume=35|issue=6|pages=739–748|doi=10.1002/1096-9888(200006)35:6<739::aid-jms3>3.0.co;2-#|issn=1076-5174}}</ref><ref>{{Cite journal|last=Kleinnijenhuis|first=Anne J.|last2=Duursma|first2=Marc C.|last3=Breukink|first3=Eefjan|last4=Heeren|first4=Ron M. A.|last5=Heck|first5=Albert J. R.|date=2003-07-01|title=Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation|url=https://pubmed.ncbi.nlm.nih.gov/12964772/|journal=Analytical Chemistry|volume=75|issue=13|pages=3219–3225|doi=10.1021/ac0263770|issn=0003-2700|pmid=12964772}}</ref>
During his postdoctoral fellowship, he worked on the development of innovative ion sources, vacuums systems, data acquisition systems and novel temperature-controlled ion cyclotron resonance cells. He used the FTICR-MS instrument for the study of collisional energy transfer and internal energy distributions.<ref>{{Cite journal|last1=Heeren|first1=Ron M. A.|last2=Vékey|first2=Károly|date=1998-09-15|title=A novel method to determine collisional energy transfer efficiency by Fourier transform ion cyclotron resonance mass spectrometry|url=http://dx.doi.org/10.1002/(sici)1097-0231(19980915)12:17<1175::aid-rcm305>3.0.co;2-l|journal=Rapid Communications in Mass Spectrometry|volume=12|issue=17|pages=1175–1181|doi=10.1002/(sici)1097-0231(19980915)12:17<1175::aid-rcm305>3.0.co;2-l|issn=0951-4198}}</ref><ref>{{Cite journal|last1=Drahos|first1=null|last2=Heeren|first2=null|last3=Collette|first3=null|last4=De Pauw E|first4=null|last5=Vekey|first5=null|date=December 1999|title=Thermal energy distribution observed in electrospray ionization|url=https://pubmed.ncbi.nlm.nih.gov/10587635/|journal=Journal of Mass Spectrometry |volume=34|issue=12|pages=1373–1379|doi=10.1002/(SICI)1096-9888(199912)34:12<1373::AID-JMS907>3.0.CO;2-#|issn=1096-9888|pmid=10587635|bibcode=1999JMSp...34.1373D}}</ref><ref>{{Cite journal|last1=Guo|first1=Xinghua|last2=Duursma|first2=Marc C.|last3=Kistemaker|first3=Piet G.|last4=Nibbering|first4=Nico M. M.|last5=Vekey|first5=Karoly|last6=Drahos|first6=Laszlo|last7=Heeren|first7=Ron M. A.|date=June 2003|title=Manipulating internal energy of protonated biomolecules in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry|url=https://pubmed.ncbi.nlm.nih.gov/12827629/|journal=Journal of Mass Spectrometry |volume=38|issue=6|pages=597–606|doi=10.1002/jms.480|issn=1076-5174|pmid=12827629|bibcode=2003JMSp...38..597G}}</ref> These methods were deployed to investigate their role in the determination of dissociation pathways of biomolecular systems.<ref>{{Cite journal|last1=Koster|first1=Sander|last2=Duursma|first2=Marc C.|last3=Boon|first3=Jaap J.|last4=Nielen|first4=Michel W. F.|last5=de Koster|first5=Chris G.|last6=Heeren|first6=Ron M. A.|date=2000|title=Structural analysis of synthetic homo- and copolyesters by electrospray ionization on a Fourier transform ion cyclotron resonance mass spectrometer|url=http://dx.doi.org/10.1002/1096-9888(200006)35:6<739::aid-jms3>3.0.co;2-#|journal=Journal of Mass Spectrometry|volume=35|issue=6|pages=739–748|doi=10.1002/1096-9888(200006)35:6<739::aid-jms3>3.0.co;2-#|pmid=10862127|bibcode=2000JMSp...35..739K|issn=1076-5174}}</ref><ref>{{Cite journal|last1=Kleinnijenhuis|first1=Anne J.|last2=Duursma|first2=Marc C.|last3=Breukink|first3=Eefjan|last4=Heeren|first4=Ron M. A.|last5=Heck|first5=Albert J. R.|date=2003-07-01|title=Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation|url=https://pubmed.ncbi.nlm.nih.gov/12964772/|journal=Analytical Chemistry|volume=75|issue=13|pages=3219–3225|doi=10.1021/ac0263770|issn=0003-2700|pmid=12964772|hdl=1874/14955|s2cid=17450996 |hdl-access=free}}</ref>


As a project leader (1995–1997), Heeren led the application of high-resolution MS (FTICR-MS, FTIR imaging spectroscopy and SIMS) to the field of conservation science. He discovered and identified saponified pigment particulates in so-called protrusions in Rembrandt’s “[[The Anatomy Lesson of Dr. Nicolaes Tulp]]” in collaboration with the [[Mauritshuis]] museum in The Hague.<ref>{{Cite journal|last=Heeren|first=Ron M. A.|last2=Boon|first2=Jaap J.|last3=Noble|first3=Petria|last4=Wadum|first4=Jørgen|date=1999|title=Integrating imaging FTIR and secondary ion mass spectrometry for the analysis of embedded paint cross-sections|url=https://pure.kb.dk/en/publications/integrating-imaging-ftir-and-secondary-ion-mass-spectrometry-for-|journal=ICOM-CC Triennial meeting (12th), Lyon, 29 August-3 September 1999: preprints.|language=English|pages=228–233}}</ref><ref>{{Citation|title=Recitative after Rembrandt’s “The Anatomy Lesson of Dr. Nicolaes Tulp”|date=2005-03-23|url=http://dx.doi.org/10.2307/j.ctvthhc5r.38|work=90 Miles|pages=78–79|publisher=University of Pittsburgh Press|isbn=978-0-8229-8033-9|access-date=2020-12-18}}</ref><ref>{{Cite journal|last=Van Der Weerd|first=J.|last2=Brammer|first2=H.|last3=Boon|first3=J. J.|last4=Heeren|first4=R. M. A.|date=March 2002|title=Fourier Transform Infrared Microscopic Imaging of an Embedded Paint Cross-Section|url=http://dx.doi.org/10.1366/0003702021954683|journal=Applied Spectroscopy|volume=56|issue=3|pages=275–283|doi=10.1366/0003702021954683|issn=0003-7028}}</ref>
As a project leader (1995–1997), Heeren led the application of high-resolution MS (FTICR-MS, FTIR imaging spectroscopy and SIMS) to the field of conservation science. He discovered and identified saponified pigment particulates in so-called protrusions in Rembrandt’s “[[The Anatomy Lesson of Dr. Nicolaes Tulp]]” in collaboration with the [[Mauritshuis]] museum in The Hague.<ref>{{Cite journal|last1=Heeren|first1=Ron M. A.|last2=Boon|first2=Jaap J.|last3=Noble|first3=Petria|last4=Wadum|first4=Jørgen|date=1999|title=Integrating imaging FTIR and secondary ion mass spectrometry for the analysis of embedded paint cross-sections|url=https://pure.kb.dk/en/publications/integrating-imaging-ftir-and-secondary-ion-mass-spectrometry-for-|journal=ICOM-CC Triennial Meeting (12th), Lyon, 29 August-3 September 1999: Preprints.|language=English|pages=228–233}}</ref><ref>{{Citation|title=Recitative after Rembrandt's "The Anatomy Lesson of Dr. Nicolaes Tulp"|date=2005-03-23|url=http://dx.doi.org/10.2307/j.ctvthhc5r.38|work=90 Miles|pages=78–79|publisher=University of Pittsburgh Press|doi=10.2307/j.ctvthhc5r.38|isbn=978-0-8229-8033-9|access-date=2020-12-18}}</ref><ref>{{Cite journal|last1=Van Der Weerd|first1=J.|last2=Brammer|first2=H.|last3=Boon|first3=J. J.|last4=Heeren|first4=R. M. A.|date=March 2002|title=Fourier Transform Infrared Microscopic Imaging of an Embedded Paint Cross-Section|url=http://dx.doi.org/10.1366/0003702021954683|journal=Applied Spectroscopy|volume=56|issue=3|pages=275–283|doi=10.1366/0003702021954683|bibcode=2002ApSpe..56Q.275V|s2cid=95454503|issn=0003-7028}}</ref>


Heeren and his group have pioneered the development of active pixelated detectors for mass spectrometry imaging. One such detector, the [[Medipix]] detector has been adapted to enable microscope-mode imaging mass spectrometry<ref>{{Cite journal|last=Jungmann|first=Julia H.|last2=MacAleese|first2=Luke|last3=Visser|first3=Jan|last4=Vrakking|first4=Marc J. J.|last5=Heeren|first5=Ron M. A.|date=2011-10-15|title=High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector|url=http://dx.doi.org/10.1021/ac2017629|journal=Analytical Chemistry|volume=83|issue=20|pages=7888–7894|doi=10.1021/ac2017629|issn=0003-2700}}</ref> for biomolecules to enable combined high-throughput and high-resolution molecular imaging using [[Matrix-assisted laser desorption/ionization|MALDI]] and [[Secondary ion mass spectrometry|SIMS]].
Heeren and his group have pioneered the development of active pixelated detectors for mass spectrometry imaging. One such detector, the [[Medipix]] detector has been adapted to enable microscope-mode imaging mass spectrometry<ref>{{Cite journal|last1=Jungmann|first1=Julia H.|last2=MacAleese|first2=Luke|last3=Visser|first3=Jan|last4=Vrakking|first4=Marc J. J.|last5=Heeren|first5=Ron M. A.|date=2011-10-15|title=High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector|url=http://dx.doi.org/10.1021/ac2017629|journal=Analytical Chemistry|volume=83|issue=20|pages=7888–7894|doi=10.1021/ac2017629|pmid=21882854|issn=0003-2700}}</ref> for biomolecules to enable combined high-throughput and high-resolution molecular imaging using [[Matrix-assisted laser desorption/ionization|MALDI]] and [[Secondary ion mass spectrometry|SIMS]].


== Education ==
== Professional activities ==
Prof. Heeren is only one of four distinguished professors at UM.<ref>{{Cite web|title=Distinguished university professors - Research - Maastricht University|url=https://www.maastrichtuniversity.nl/research/distinguished-university-professors|access-date=2020-12-18|website=www.maastrichtuniversity.nl}}</ref> He has supervised more than 60 PhD students and postdoctoral fellows, many of whom have received prestigious awards ([https://www.nwo.nl/en/calls/talent-programme NWO-Vidi] and [https://erc.europa.eu/ ERC grants], for example). Currently, he supervises masters and PhD students at UM, Vrije Universiteit Amsterdam, and the University of Amsterdam.


From 2008 to 2013, Heeren was the research director for emerging technologies at the [[Netherlands Proteomics Centre]]. In 2014, he was appointed to his current position as one of the scientific directors of M4I at Maastricht University.<ref>{{Cite web|title=Maastricht University Magazine October 2014|url=https://issuu.com/maastrichtuniversity/docs/mum_oktober_14|access-date=2020-12-18|website=Issuu|date=14 October 2014 |language=en}}</ref> He was president of the Dutch Society of Mass Spectrometry between 2001–2005.<ref>{{Cite web|title=History|url=https://www.nvms.nl/index.php/historie/|access-date=2020-12-18|website=NVMS|language=en-US}}</ref> He is one of the founding members of the Mass Spectrometry Imaging Society, and was elected its president in 2017.<ref>{{Cite web|title=Mass Spectrometry Imaging Society – MS Imaging|url=https://ms-imaging.org/wp/mass-spectrometry-imaging-society/|access-date=2020-12-18|website=ms-imaging.org}}</ref>
He delivered a tutorial lecture on Imaging MS at the 2014 annual ASMS conference<ref>{{Citation|last=ASMS|title=Imaging MS: 2014 Tutorial, Ron M.A. Heeren|date=2014-09-06|url=https://vimeo.com/105423855|access-date=2020-12-18}}</ref> and a TEDx Maastricht talk<ref>{{Cite web|title=The New Dawn of Cancer Surgery {{!}} Ron Heeren {{!}} TEDxMaastricht - YouTube|url=https://www.youtube.com/watch?v=tHdvxB23U4Y|access-date=2020-12-18|website=www.youtube.com}}</ref>.


== Commercialization ==
Prof. Heeren is part of the organizing committee of the annual [http://msbm.org/ Mass Spectrometry School in Biotechnology and Medicine summer school] in Dubrovnik. He has designed and established a molecular imaging track in the Biomedical Sciences Master programme and is coordinating the establishment of a new Molecular Imaging and Engineering Master program at UM.
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Heeren holds 7 patents and has established two spin-off companies, [https://www.amscins.com/ Omics2Image/ASI] and the [https://www.hairdiagnostix.nl/ Dutch Screening Group]. In 2019, he was awarded the NWO Valorisation Prize in Physics.<ref>{{Cite web|title=NWO Physics Valorisation Prize 2019 - Ron Heeren - YouTube|url=https://www.youtube.com/watch?v=fCa7VtLT2r4|access-date=2020-12-18|website=www.youtube.com| date=8 January 2020 }}</ref><ref>{{Cite web|title=NWO Physics Valorisation Prize goes to Ron Heeren from Maastricht University {{!}} NWO|url=https://www.nwo.nl/en/news/nwo-physics-valorisation-prize-goes-ron-heeren-maastricht-university|access-date=2020-12-18|website=www.nwo.nl|language=en}}</ref>


== Awards ==
== Awards ==
2020     Hans Fisher Senior Fellowship, Institute of Advanced Studies, Technical University of Munich Hans Fisher senior fellowship<ref>{{Cite web|title=Heeren, Ron M.A. - Institute for Advanced Study (IAS)|url=https://www.ias.tum.de/active-fellows/heeren-ron-ma/|access-date=2020-12-18|website=www.ias.tum.de|language=de}}</ref>


2020     Thomson medal, International Mass Spectrometry Foundation for distinguished contribution to international MS<ref>{{Cite web|title=International Mass Spectronomy Foundation|url=https://www.imss.nl/awards.html|access-date=2020-12-18|website=www.imss.nl}}</ref>
* 2020     Hans Fisher Senior Fellowship, Institute of Advanced Studies, Technical University of Munich Hans Fisher senior fellowship<ref>{{Cite web|title=Heeren, Ron M.A. - Institute for Advanced Study (IAS)|url=https://www.ias.tum.de/active-fellows/heeren-ron-ma/|access-date=2020-12-18|website=www.ias.tum.de|language=de}}</ref>
* 2020     Thomson medal, International Mass Spectrometry Foundation for distinguished contribution to international MS<ref>{{Cite web|last=Maastricht|first=Minderbroedersberg 4-6 6211 LK|title=Thomson Medal 2020 awarded to Ron Heeren|url=https://www.maastrichtuniversity.nl/news/thomson-medal-2020-awarded-ron-heeren|access-date=2020-12-18|website=www.maastrichtuniversity.nl|date=25 May 2020 |language=en}}</ref><ref>{{Cite web|title=International Mass Spectronomy Foundation|url=https://www.imss.nl/awards.html|access-date=2020-12-18|website=www.imss.nl}}</ref>
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* 2019     NWO-Physics Valorisation prize (see above)
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* 2019     Brightlands Convention Award<ref>{{Cite web|last=Redactie|date=2019-03-27|title=Uitreiking Brightlands Convention Award 2018|url=https://conferencematters.nl/nl/uitreiking-brightlands-convention-award-2018/|access-date=2020-12-18|website=Conference Matters|language=nl-NL}}</ref>
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* 2014     Robert Feulgen lecturer, Society for Histochemistry<ref>{{Cite web|title=Society for Histochemistry|url=http://www.histochemistry.eu/index.php?page=feulgen_lectures|access-date=2020-12-18|website=www.histochemistry.eu}}</ref>
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* 2013     Winner, 10th Venture Challenge, Netherlands Genomics Initiative<ref>{{Cite web|last=|first=|date=|title=Press release: Omics2Image wins Venture Challenge Spring 2013|url=https://www.venturechallenge.nl/Mailings/Persbericht_VC_Spring2013.pdf|archive-url=|archive-date=|access-date=|website=}}</ref>
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* 2012     Award, Exploratory Measurement Science Group (EMSG), University of Edinburgh, UK
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* 2010     Distinguished Wiley Visiting Scientist award, Environmental Molecular Sciences Laboratory, Department of Energy, US<ref>{{Cite web|title=iDirector interview with Ron Heeren - YouTube|url=https://www.youtube.com/watch?v=vFt1CzN5Yvo|access-date=2020-12-18|website=www.youtube.com| date=28 June 2012 }}</ref><ref>{{Cite web|last=|first=|date=|title=New EMSL Visiting Scientists Named|url=https://www.emsl.pnnl.gov/News/new-emsl-visiting-scientists-named/71|archive-url=|archive-date=|access-date=|website=}}</ref>
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* 2008     RCM Beynon Prize, Rapid Communications in Mass Spectrometry<ref>{{Cite web|title=Rapid Communications in Mass Spectrometry|url=https://onlinelibrary.wiley.com/page/journal/10970231/homepage/rcm_beynon_award.htm|access-date=2020-12-18|website=Wiley Online Library|language=en}}</ref>
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* 2002     Bert L. Schram Award, Dutch Society for Mass Spectrometry (NVMS)


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== Most cited publications ==
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2019     NWO-Physics Valorisation prize (see above)
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# {{Cite journal|last1=Ščupáková|first1=Klára|last2=Dewez|first2=Frédéric|last3=Walch|first3=Axel K.|last4=Heeren|first4=Ron M. A.|last5=Balluff|first5=Benjamin|date=2020-08-17|title=Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging|url= |journal=Angewandte Chemie International Edition|volume=59|issue=40|pages=17447–17450|doi=10.1002/anie.202007315|pmid=32668069|pmc=7540554|issn=1433-7851}}
⚫
# {{Cite journal|last1=Ellis|first1=Shane R.|last2=Paine|first2=Martin R. L.|last3=Eijkel|first3=Gert B.|last4=Pauling|first4=Josch K.|last5=Husen|first5=Peter|last6=Jervelund|first6=Mark W.|last7=Hermansson|first7=Martin|last8=Ejsing|first8=Christer S.|last9=Heeren|first9=Ron M. A.|date=2018-05-21|title=Automated, parallel mass spectrometry imaging and structural identification of lipids|url=http://dx.doi.org/10.1038/s41592-018-0010-6|journal=Nature Methods|volume=15|issue=7|pages=515–518|doi=10.1038/s41592-018-0010-6|pmid=29786091|s2cid=29162438|issn=1548-7091}}
⚫
# {{Cite journal|last1=Bruinen|first1=Anne L.|last2=Fisher|first2=Gregory L.|last3=Balez|first3=Rachelle|last4=van der Sar|first4=Astrid M.|last5=Ooi|first5=Lezanne|last6=Heeren|first6=Ron M. A.|date=2018-06-12|title=Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry|url= |journal=Journal of the American Society for Mass Spectrometry|volume=29|issue=8|pages=1571–1581|doi=10.1007/s13361-018-1979-x|pmid=29949055|pmc=6060986|bibcode=2018JASMS..29.1571B|issn=1044-0305}}
⚫
# {{Cite journal|last1=Ščupáková|first1=Klára|last2=Soons|first2=Zita|last3=Ertaylan|first3=Gökhan|last4=Pierzchalski|first4=Keely A.|last5=Eijkel|first5=Gert B.|last6=Ellis|first6=Shane R.|last7=Greve|first7=Jan W.|last8=Driessen|first8=Ann|last9=Verheij|first9=Joanne|last10=De Kok|first10=Theo M.|last11=Olde Damink|first11=Steven W. M.|date=17 April 2018|title=Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity|journal=Analytical Chemistry|volume=90|issue=8|pages=5130–5138|doi=10.1021/acs.analchem.7b05215|issn=1520-6882|pmc=5906754|pmid=29570976}}
⚫
# {{Cite journal|last1=Ellis|first1=S. R.|last2=Soltwisch|first2=J.|last3=Paine|first3=M. R. L.|last4=Dreisewerd|first4=K.|last5=Heeren|first5=R. M. A.|date=2017|title=Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids|url=http://dx.doi.org/10.1039/c7cc02325a|journal=Chemical Communications|volume=53|issue=53|pages=7246–7249|doi=10.1039/c7cc02325a|pmid=28573274|s2cid=4627246 |issn=1359-7345}}
⚫
# {{Cite journal|last1=Ogrinc Potočnik|first1=Nina|last2=Porta|first2=Tiffany|last3=Becker|first3=Michael|last4=Heeren|first4=Ron M. A.|last5=Ellis|first5=Shane R.|date=2015-10-28|title=Use of advantageous, volatile matrices enabled by next-generation high-speed matrix-assisted laser desorption/ionization time-of-flight imaging employing a scanning laser beam|url=http://dx.doi.org/10.1002/rcm.7379|journal=Rapid Communications in Mass Spectrometry|volume=29|issue=23|pages=2195–2203|doi=10.1002/rcm.7379|pmid=26522310|bibcode=2015RCMS...29.2195O|issn=0951-4198}}
⚫
# {{Cite journal|last1=Ellis|first1=Shane R.|last2=Jungmann|first2=Julia H.|last3=Smith|first3=Donald F.|last4=Soltwisch|first4=Jens|last5=Heeren|first5=Ron M. A.|date=2013-10-18|title=Enhanced detection of high-mass proteins by using an active pixel detector|url=https://pubmed.ncbi.nlm.nih.gov/24039122/|journal=Angewandte Chemie International Edition in English |volume=52|issue=43|pages=11261–11264|doi=10.1002/anie.201305501|issn=1521-3773|pmid=24039122}}
⚫
# {{Cite journal|last1=Jungmann|first1=Julia H.|last2=Smith|first2=Donald F.|last3=MacAleese|first3=Luke|last4=Klinkert|first4=Ivo|last5=Visser|first5=Jan|last6=Heeren|first6=Ron M. A.|date=2012-07-27|title=Biological Tissue Imaging with a Position and Time Sensitive Pixelated Detector|url=http://dx.doi.org/10.1007/s13361-012-0444-5|journal=Journal of the American Society for Mass Spectrometry|volume=23|issue=10|pages=1679–1688|doi=10.1007/s13361-012-0444-5|pmid=22836864|arxiv=1305.5437|bibcode=2012JASMS..23.1679J|s2cid=13480751|issn=1044-0305}}
⚫
# {{Cite journal|last1=Jungmann|first1=Julia H.|last2=MacAleese|first2=Luke|last3=Visser|first3=Jan|last4=Vrakking|first4=Marc J. J.|last5=Heeren|first5=Ron M. A.|date=2011-10-15|title=High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector|url=http://dx.doi.org/10.1021/ac2017629|journal=Analytical Chemistry|volume=83|issue=20|pages=7888–7894|doi=10.1021/ac2017629|pmid=21882854|issn=0003-2700}}
⚫
# {{Cite journal|last1=Chughtai|first1=Kamila|last2=Heeren|first2=Ron M. A.|date=2010-05-12|title=Mass Spectrometric Imaging for Biomedical Tissue Analysis|url= |journal=Chemical Reviews|volume=110|issue=5|pages=3237–3277|doi=10.1021/cr100012c|pmid=20423155|pmc=2907483|issn=0009-2665}}


⚫
== References ==
⚫
2019     Brightlands Convention Award<ref>{{Cite web|last=Redactie|date=2019-03-27|title=Uitreiking Brightlands Convention Award 2018|url=https://conferencematters.nl/nl/uitreiking-brightlands-convention-award-2018/|access-date=2020-12-18|website=Conference Matters|language=nl-NL}}</ref>
⚫
{{reflist}}


{{Thomson Medal Recipients}}
⚫
2014     Robert Feulgen lecturer, Society for Histochemistry<ref>{{Cite web|title=Society for Histochemistry|url=http://www.histochemistry.eu/index.php?page=feulgen_lectures|access-date=2020-12-18|website=www.histochemistry.eu}}</ref>


{{authority control}}
⚫
2013     Winner, 10th Venture Challenge, Netherlands Genomics Initiative<ref>{{Cite web|last=|first=|date=|title=Press release: Omics2Image wins Venture Challenge Spring 2013|url=https://www.venturechallenge.nl/Mailings/Persbericht_VC_Spring2013.pdf|url-status=live|archive-url=|archive-date=|access-date=|website=}}</ref>


{{DEFAULTSORT:Heeren, Ron}}
⚫
2012     Award, Exploratory Measurement Science Group (EMSG), University of Edinburgh, UK


[[Category:1965 births]]
⚫
2010     Distinguished Wiley Visiting Scientist award, Environmental Molecular Sciences Laboratory, Department of Energy, US<ref>{{Cite web|title=iDirector interview with Ron Heeren - YouTube|url=https://www.youtube.com/watch?v=vFt1CzN5Yvo|access-date=2020-12-18|website=www.youtube.com}}</ref><ref>{{Cite web|last=|first=|date=|title=New EMSL Visiting Scientists Named|url=https://www.emsl.pnnl.gov/News/new-emsl-visiting-scientists-named/71|url-status=live|archive-url=|archive-date=|access-date=|website=}}</ref>
[[Category:People from Tilburg]]

[[Category:21st-century Dutch chemists]]
⚫
2008     RCM Beynon Prize, Rapid Communications in Mass Spectrometry<ref>{{Cite web|title=Rapid Communications in Mass Spectrometry|url=https://onlinelibrary.wiley.com/page/journal/10970231/homepage/rcm_beynon_award.htm|access-date=2020-12-18|website=Wiley Online Library|language=en}}</ref>
[[Category:Academic staff of Maastricht University]]

[[Category:Living people]]
⚫
2002     Bert L. Schram Award, Dutch Society for Mass Spectrometry (NVMS)
[[Category:Thomson Medal recipients]]

[[Category:Mass spectrometrists]]
⚫
== Ten major publications ==
[[Category:University of Amsterdam alumni]]

⚫
# Ščupáková, Klára; Dewez, Frédéric; Walch, Axel K.; Heeren, Ron M. A.; Balluff, Benjamin (2020-08-17). "Morphometric Cell Classification for Single‐Cell MALDI‐Mass Spectrometry Imaging". ''Angewandte Chemie International Edition''. '''59''' (40): 17447–17450.<ref>{{Cite journal|last=Ščupáková|first=Klára|last2=Dewez|first2=Frédéric|last3=Walch|first3=Axel K.|last4=Heeren|first4=Ron M. A.|last5=Balluff|first5=Benjamin|date=2020-08-17|title=Morphometric Cell Classification for Single‐Cell MALDI‐Mass Spectrometry Imaging|url=http://dx.doi.org/10.1002/anie.202007315|journal=Angewandte Chemie International Edition|volume=59|issue=40|pages=17447–17450|doi=10.1002/anie.202007315|issn=1433-7851}}</ref>
⚫
# Ellis, Shane R.; Paine, Martin R. L.; Eijkel, Gert B.; Pauling, Josch K.; Husen, Peter; Jervelund, Mark W.; Hermansson, Martin; Ejsing, Christer S.; Heeren, Ron M. A. (2018-05-21). "Automated, parallel mass spectrometry imaging and structural identification of lipids". ''Nature Methods''. '''15''' (7): 515–518.<ref>{{Cite journal|last=Ellis|first=Shane R.|last2=Paine|first2=Martin R. L.|last3=Eijkel|first3=Gert B.|last4=Pauling|first4=Josch K.|last5=Husen|first5=Peter|last6=Jervelund|first6=Mark W.|last7=Hermansson|first7=Martin|last8=Ejsing|first8=Christer S.|last9=Heeren|first9=Ron M. A.|date=2018-05-21|title=Automated, parallel mass spectrometry imaging and structural identification of lipids|url=http://dx.doi.org/10.1038/s41592-018-0010-6|journal=Nature Methods|volume=15|issue=7|pages=515–518|doi=10.1038/s41592-018-0010-6|issn=1548-7091}}</ref>
⚫
# Bruinen, Anne L.; Fisher, Gregory L.; Balez, Rachelle; van der Sar, Astrid M.; Ooi, Lezanne; Heeren, Ron M. A. (2018-06-12). "Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry". ''Journal of The American Society for Mass Spectrometry''. '''29''' (8): 1571–1581.<ref>{{Cite journal|last=Bruinen|first=Anne L.|last2=Fisher|first2=Gregory L.|last3=Balez|first3=Rachelle|last4=van der Sar|first4=Astrid M.|last5=Ooi|first5=Lezanne|last6=Heeren|first6=Ron M. A.|date=2018-06-12|title=Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry|url=http://dx.doi.org/10.1007/s13361-018-1979-x|journal=Journal of The American Society for Mass Spectrometry|volume=29|issue=8|pages=1571–1581|doi=10.1007/s13361-018-1979-x|issn=1044-0305}}</ref>
⚫
# Ščupáková, Klára; Soons, Zita; Ertaylan, Gökhan; Pierzchalski, Keely A.; Eijkel, Gert B.; Ellis, Shane R.; Greve, Jan W.; Driessen, Ann; Verheij, Joanne; De Kok, Theo M.; Olde Damink, Steven W. M. (04 17, 2018). "Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity". ''Analytical Chemistry''. '''90''' (8): 5130–5138.<ref>{{Cite journal|last=Ščupáková|first=Klára|last2=Soons|first2=Zita|last3=Ertaylan|first3=Gökhan|last4=Pierzchalski|first4=Keely A.|last5=Eijkel|first5=Gert B.|last6=Ellis|first6=Shane R.|last7=Greve|first7=Jan W.|last8=Driessen|first8=Ann|last9=Verheij|first9=Joanne|last10=De Kok|first10=Theo M.|last11=Olde Damink|first11=Steven W. M.|date=04 17, 2018|title=Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity|url=https://pubmed.ncbi.nlm.nih.gov/29570976/|journal=Analytical Chemistry|volume=90|issue=8|pages=5130–5138|doi=10.1021/acs.analchem.7b05215|issn=1520-6882|pmc=5906754|pmid=29570976}}</ref>
⚫
# Ellis, S. R.; Soltwisch, J.; Paine, M. R. L.; Dreisewerd, K.; Heeren, R. M. A. (2017). "Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids". ''Chemical Communications''. '''53''' (53): 7246–7249.<ref>{{Cite journal|last=Ellis|first=S. R.|last2=Soltwisch|first2=J.|last3=Paine|first3=M. R. L.|last4=Dreisewerd|first4=K.|last5=Heeren|first5=R. M. A.|date=2017|title=Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids|url=http://dx.doi.org/10.1039/c7cc02325a|journal=Chemical Communications|volume=53|issue=53|pages=7246–7249|doi=10.1039/c7cc02325a|issn=1359-7345}}</ref>
⚫
# Ogrinc Potočnik, Nina; Porta, Tiffany; Becker, Michael; Heeren, Ron M. A.; Ellis, Shane R. (2015-10-28). "Use of advantageous, volatile matrices enabled by next-generation high-speed matrix-assisted laser desorption/ionization time-of-flight imaging employing a scanning laser beam". ''Rapid Communications in Mass Spectrometry''. '''29''' (23): 2195–2203.<ref>{{Cite journal|last=Ogrinc Potočnik|first=Nina|last2=Porta|first2=Tiffany|last3=Becker|first3=Michael|last4=Heeren|first4=Ron M. A.|last5=Ellis|first5=Shane R.|date=2015-10-28|title=Use of advantageous, volatile matrices enabled by next-generation high-speed matrix-assisted laser desorption/ionization time-of-flight imaging employing a scanning laser beam|url=http://dx.doi.org/10.1002/rcm.7379|journal=Rapid Communications in Mass Spectrometry|volume=29|issue=23|pages=2195–2203|doi=10.1002/rcm.7379|issn=0951-4198}}</ref>
⚫
# Ellis, Shane R.; Jungmann, Julia H.; Smith, Donald F.; Soltwisch, Jens; Heeren, Ron M. A. (2013-10-18). "Enhanced detection of high-mass proteins by using an active pixel detector". ''Angewandte Chemie (International Ed. in English)''. '''52''' (43): 11261–11264.<ref>{{Cite journal|last=Ellis|first=Shane R.|last2=Jungmann|first2=Julia H.|last3=Smith|first3=Donald F.|last4=Soltwisch|first4=Jens|last5=Heeren|first5=Ron M. A.|date=2013-10-18|title=Enhanced detection of high-mass proteins by using an active pixel detector|url=https://pubmed.ncbi.nlm.nih.gov/24039122/|journal=Angewandte Chemie (International Ed. in English)|volume=52|issue=43|pages=11261–11264|doi=10.1002/anie.201305501|issn=1521-3773|pmid=24039122}}</ref>
⚫
# Jungmann, Julia H.; Smith, Donald F.; MacAleese, Luke; Klinkert, Ivo; Visser, Jan; Heeren, Ron M. A. (2012-07-27). "Biological Tissue Imaging with a Position and Time Sensitive Pixelated Detector". ''Journal of The American Society for Mass Spectrometry''. '''23''' (10): 1679–1688.<ref>{{Cite journal|last=Jungmann|first=Julia H.|last2=Smith|first2=Donald F.|last3=MacAleese|first3=Luke|last4=Klinkert|first4=Ivo|last5=Visser|first5=Jan|last6=Heeren|first6=Ron M. A.|date=2012-07-27|title=Biological Tissue Imaging with a Position and Time Sensitive Pixelated Detector|url=http://dx.doi.org/10.1007/s13361-012-0444-5|journal=Journal of The American Society for Mass Spectrometry|volume=23|issue=10|pages=1679–1688|doi=10.1007/s13361-012-0444-5|issn=1044-0305}}</ref>
⚫
# Jungmann, Julia H.; MacAleese, Luke; Visser, Jan; Vrakking, Marc J. J.; Heeren, Ron M. A. (2011-10-15). "High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector". ''Analytical Chemistry''. '''83''' (20): 7888–7894.<ref>{{Cite journal|last=Jungmann|first=Julia H.|last2=MacAleese|first2=Luke|last3=Visser|first3=Jan|last4=Vrakking|first4=Marc J. J.|last5=Heeren|first5=Ron M. A.|date=2011-10-15|title=High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector|url=http://dx.doi.org/10.1021/ac2017629|journal=Analytical Chemistry|volume=83|issue=20|pages=7888–7894|doi=10.1021/ac2017629|issn=0003-2700}}</ref>
⚫
# Chughtai, Kamila; Heeren, Ron M. A. (2010-05-12). "Mass Spectrometric Imaging for Biomedical Tissue Analysis". ''Chemical Reviews''. '''110''' (5): 3237–3277.<ref>{{Cite journal|last=Chughtai|first=Kamila|last2=Heeren|first2=Ron M. A.|date=2010-05-12|title=Mass Spectrometric Imaging for Biomedical Tissue Analysis|url=http://dx.doi.org/10.1021/cr100012c|journal=Chemical Reviews|volume=110|issue=5|pages=3237–3277|doi=10.1021/cr100012c|issn=0009-2665}}</ref>

⚫
== References ==
<!-- Inline citations added to your article will automatically display here. See en.wikipedia.org/wiki/WP:REFB for instructions on how to add citations. -->
⚫
{{reflist}}

Latest revision as of 20:01, 23 November 2024

Ron M.A. Heeren
Ron Heeren in 2017
Born1965
Tilburg, Netherlands
NationalityDutch
Alma materUniversity of Amsterdam
AwardsHans Fisher Fellowship; Thomson Medal of IMSF; NWO-Physics Valorisation Prize; Brightlands Convention Award; Robert Feulgen lecturer, Society for Histochemistry; Distinguished Wiley Visiting Scientist award;
Scientific career
FieldsImaging Mass Spectrometry

Ron M.A. Heeren (born 1965, Tilburg) is a Dutch scientist in mass spectrometry imaging. He is currently a distinguished professor at Maastricht University and the scientific director of the Multimodal Molecular Imaging Institute (M4I), where he heads the division of Imaging Mass Spectrometry.

Scientific career

[edit]

Heeren obtained a PhD degree in Technical Physics at the University of Amsterdam in 1992 under the supervision of Aart Kleyn.

He led a FOM-AMOLF research group on macromolecular ion physics and biomolecular imaging mass spectrometry (1995–2014). He was also professor at the chemistry faculty of Utrecht University in 2001–2019.

Between 1995 and 2015, he worked on new approaches towards high spatial resolution and high-throughput molecular imaging mass spectrometry using secondary ion mass spectrometry (SIMS) and matrix-assisted laser desorption and ionization (MALDI).

Heeren has coauthored over 300 peer-reviewed articles, which have been cited over 12,600 times (Google Scholar).[1]

Research

[edit]

Heeren’s academic research interests are fundamental studies of the energetics of macromolecular systems, conformational studies of non-covalently bound protein complexes, translational imaging research, high-throughput bioinformatics, and the development and validation of new mass spectrometry–based proteomic imaging techniques for the life sciences.

During his postdoctoral fellowship, he worked on the development of innovative ion sources, vacuums systems, data acquisition systems and novel temperature-controlled ion cyclotron resonance cells. He used the FTICR-MS instrument for the study of collisional energy transfer and internal energy distributions.[2][3][4] These methods were deployed to investigate their role in the determination of dissociation pathways of biomolecular systems.[5][6]

As a project leader (1995–1997), Heeren led the application of high-resolution MS (FTICR-MS, FTIR imaging spectroscopy and SIMS) to the field of conservation science. He discovered and identified saponified pigment particulates in so-called protrusions in Rembrandt’s “The Anatomy Lesson of Dr. Nicolaes Tulp” in collaboration with the Mauritshuis museum in The Hague.[7][8][9]

Heeren and his group have pioneered the development of active pixelated detectors for mass spectrometry imaging. One such detector, the Medipix detector has been adapted to enable microscope-mode imaging mass spectrometry[10] for biomolecules to enable combined high-throughput and high-resolution molecular imaging using MALDI and SIMS.

Professional activities

[edit]

From 2008 to 2013, Heeren was the research director for emerging technologies at the Netherlands Proteomics Centre. In 2014, he was appointed to his current position as one of the scientific directors of M4I at Maastricht University.[11] He was president of the Dutch Society of Mass Spectrometry between 2001–2005.[12] He is one of the founding members of the Mass Spectrometry Imaging Society, and was elected its president in 2017.[13]

Commercialization

[edit]

Heeren holds 7 patents and has established two spin-off companies, Omics2Image/ASI and the Dutch Screening Group. In 2019, he was awarded the NWO Valorisation Prize in Physics.[14][15]

Awards

[edit]
  • 2020     Hans Fisher Senior Fellowship, Institute of Advanced Studies, Technical University of Munich Hans Fisher senior fellowship[16]
  • 2020     Thomson medal, International Mass Spectrometry Foundation for distinguished contribution to international MS[17][18]
  • 2019     NWO-Physics Valorisation prize (see above)
  • 2019     Brightlands Convention Award[19]
  • 2014     Robert Feulgen lecturer, Society for Histochemistry[20]
  • 2013     Winner, 10th Venture Challenge, Netherlands Genomics Initiative[21]
  • 2012     Award, Exploratory Measurement Science Group (EMSG), University of Edinburgh, UK
  • 2010     Distinguished Wiley Visiting Scientist award, Environmental Molecular Sciences Laboratory, Department of Energy, US[22][23]
  • 2008     RCM Beynon Prize, Rapid Communications in Mass Spectrometry[24]
  • 2002     Bert L. Schram Award, Dutch Society for Mass Spectrometry (NVMS)

Most cited publications

[edit]
  1. Ščupáková, Klára; Dewez, Frédéric; Walch, Axel K.; Heeren, Ron M. A.; Balluff, Benjamin (2020-08-17). "Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging". Angewandte Chemie International Edition. 59 (40): 17447–17450. doi:10.1002/anie.202007315. ISSN 1433-7851. PMC 7540554. PMID 32668069.
  2. Ellis, Shane R.; Paine, Martin R. L.; Eijkel, Gert B.; Pauling, Josch K.; Husen, Peter; Jervelund, Mark W.; Hermansson, Martin; Ejsing, Christer S.; Heeren, Ron M. A. (2018-05-21). "Automated, parallel mass spectrometry imaging and structural identification of lipids". Nature Methods. 15 (7): 515–518. doi:10.1038/s41592-018-0010-6. ISSN 1548-7091. PMID 29786091. S2CID 29162438.
  3. Bruinen, Anne L.; Fisher, Gregory L.; Balez, Rachelle; van der Sar, Astrid M.; Ooi, Lezanne; Heeren, Ron M. A. (2018-06-12). "Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry". Journal of the American Society for Mass Spectrometry. 29 (8): 1571–1581. Bibcode:2018JASMS..29.1571B. doi:10.1007/s13361-018-1979-x. ISSN 1044-0305. PMC 6060986. PMID 29949055.
  4. Ščupáková, Klára; Soons, Zita; Ertaylan, Gökhan; Pierzchalski, Keely A.; Eijkel, Gert B.; Ellis, Shane R.; Greve, Jan W.; Driessen, Ann; Verheij, Joanne; De Kok, Theo M.; Olde Damink, Steven W. M. (17 April 2018). "Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity". Analytical Chemistry. 90 (8): 5130–5138. doi:10.1021/acs.analchem.7b05215. ISSN 1520-6882. PMC 5906754. PMID 29570976.
  5. Ellis, S. R.; Soltwisch, J.; Paine, M. R. L.; Dreisewerd, K.; Heeren, R. M. A. (2017). "Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids". Chemical Communications. 53 (53): 7246–7249. doi:10.1039/c7cc02325a. ISSN 1359-7345. PMID 28573274. S2CID 4627246.
  6. Ogrinc Potočnik, Nina; Porta, Tiffany; Becker, Michael; Heeren, Ron M. A.; Ellis, Shane R. (2015-10-28). "Use of advantageous, volatile matrices enabled by next-generation high-speed matrix-assisted laser desorption/ionization time-of-flight imaging employing a scanning laser beam". Rapid Communications in Mass Spectrometry. 29 (23): 2195–2203. Bibcode:2015RCMS...29.2195O. doi:10.1002/rcm.7379. ISSN 0951-4198. PMID 26522310.
  7. Ellis, Shane R.; Jungmann, Julia H.; Smith, Donald F.; Soltwisch, Jens; Heeren, Ron M. A. (2013-10-18). "Enhanced detection of high-mass proteins by using an active pixel detector". Angewandte Chemie International Edition in English. 52 (43): 11261–11264. doi:10.1002/anie.201305501. ISSN 1521-3773. PMID 24039122.
  8. Jungmann, Julia H.; Smith, Donald F.; MacAleese, Luke; Klinkert, Ivo; Visser, Jan; Heeren, Ron M. A. (2012-07-27). "Biological Tissue Imaging with a Position and Time Sensitive Pixelated Detector". Journal of the American Society for Mass Spectrometry. 23 (10): 1679–1688. arXiv:1305.5437. Bibcode:2012JASMS..23.1679J. doi:10.1007/s13361-012-0444-5. ISSN 1044-0305. PMID 22836864. S2CID 13480751.
  9. Jungmann, Julia H.; MacAleese, Luke; Visser, Jan; Vrakking, Marc J. J.; Heeren, Ron M. A. (2011-10-15). "High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector". Analytical Chemistry. 83 (20): 7888–7894. doi:10.1021/ac2017629. ISSN 0003-2700. PMID 21882854.
  10. Chughtai, Kamila; Heeren, Ron M. A. (2010-05-12). "Mass Spectrometric Imaging for Biomedical Tissue Analysis". Chemical Reviews. 110 (5): 3237–3277. doi:10.1021/cr100012c. ISSN 0009-2665. PMC 2907483. PMID 20423155.

References

[edit]
  1. ^ "Ron M.A. Heeren". scholar.google.nl. Retrieved 2020-12-18.
  2. ^ Heeren, Ron M. A.; Vékey, Károly (1998-09-15). <1175::aid-rcm305>3.0.co;2-l "A novel method to determine collisional energy transfer efficiency by Fourier transform ion cyclotron resonance mass spectrometry". Rapid Communications in Mass Spectrometry. 12 (17): 1175–1181. doi:10.1002/(sici)1097-0231(19980915)12:17<1175::aid-rcm305>3.0.co;2-l. ISSN 0951-4198.
  3. ^ Drahos, null; Heeren, null; Collette, null; De Pauw E, null; Vekey, null (December 1999). "Thermal energy distribution observed in electrospray ionization". Journal of Mass Spectrometry. 34 (12): 1373–1379. Bibcode:1999JMSp...34.1373D. doi:10.1002/(SICI)1096-9888(199912)34:12<1373::AID-JMS907>3.0.CO;2-#. ISSN 1096-9888. PMID 10587635.
  4. ^ Guo, Xinghua; Duursma, Marc C.; Kistemaker, Piet G.; Nibbering, Nico M. M.; Vekey, Karoly; Drahos, Laszlo; Heeren, Ron M. A. (June 2003). "Manipulating internal energy of protonated biomolecules in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry". Journal of Mass Spectrometry. 38 (6): 597–606. Bibcode:2003JMSp...38..597G. doi:10.1002/jms.480. ISSN 1076-5174. PMID 12827629.
  5. ^ Koster, Sander; Duursma, Marc C.; Boon, Jaap J.; Nielen, Michel W. F.; de Koster, Chris G.; Heeren, Ron M. A. (2000). <739::aid-jms3>3.0.co;2-# "Structural analysis of synthetic homo- and copolyesters by electrospray ionization on a Fourier transform ion cyclotron resonance mass spectrometer". Journal of Mass Spectrometry. 35 (6): 739–748. Bibcode:2000JMSp...35..739K. doi:10.1002/1096-9888(200006)35:6<739::aid-jms3>3.0.co;2-#. ISSN 1076-5174. PMID 10862127.
  6. ^ Kleinnijenhuis, Anne J.; Duursma, Marc C.; Breukink, Eefjan; Heeren, Ron M. A.; Heck, Albert J. R. (2003-07-01). "Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation". Analytical Chemistry. 75 (13): 3219–3225. doi:10.1021/ac0263770. hdl:1874/14955. ISSN 0003-2700. PMID 12964772. S2CID 17450996.
  7. ^ Heeren, Ron M. A.; Boon, Jaap J.; Noble, Petria; Wadum, Jørgen (1999). "Integrating imaging FTIR and secondary ion mass spectrometry for the analysis of embedded paint cross-sections". ICOM-CC Triennial Meeting (12th), Lyon, 29 August-3 September 1999: Preprints.: 228–233.
  8. ^ "Recitative after Rembrandt's "The Anatomy Lesson of Dr. Nicolaes Tulp"", 90 Miles, University of Pittsburgh Press, pp. 78–79, 2005-03-23, doi:10.2307/j.ctvthhc5r.38, ISBN 978-0-8229-8033-9, retrieved 2020-12-18
  9. ^ Van Der Weerd, J.; Brammer, H.; Boon, J. J.; Heeren, R. M. A. (March 2002). "Fourier Transform Infrared Microscopic Imaging of an Embedded Paint Cross-Section". Applied Spectroscopy. 56 (3): 275–283. Bibcode:2002ApSpe..56Q.275V. doi:10.1366/0003702021954683. ISSN 0003-7028. S2CID 95454503.
  10. ^ Jungmann, Julia H.; MacAleese, Luke; Visser, Jan; Vrakking, Marc J. J.; Heeren, Ron M. A. (2011-10-15). "High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector". Analytical Chemistry. 83 (20): 7888–7894. doi:10.1021/ac2017629. ISSN 0003-2700. PMID 21882854.
  11. ^ "Maastricht University Magazine October 2014". Issuu. 14 October 2014. Retrieved 2020-12-18.
  12. ^ "History". NVMS. Retrieved 2020-12-18.
  13. ^ "Mass Spectrometry Imaging Society – MS Imaging". ms-imaging.org. Retrieved 2020-12-18.
  14. ^ "NWO Physics Valorisation Prize 2019 - Ron Heeren - YouTube". www.youtube.com. 8 January 2020. Retrieved 2020-12-18.
  15. ^ "NWO Physics Valorisation Prize goes to Ron Heeren from Maastricht University | NWO". www.nwo.nl. Retrieved 2020-12-18.
  16. ^ "Heeren, Ron M.A. - Institute for Advanced Study (IAS)". www.ias.tum.de (in German). Retrieved 2020-12-18.
  17. ^ Maastricht, Minderbroedersberg 4-6 6211 LK (25 May 2020). "Thomson Medal 2020 awarded to Ron Heeren". www.maastrichtuniversity.nl. Retrieved 2020-12-18.{{cite web}}: CS1 maint: numeric names: authors list (link)
  18. ^ "International Mass Spectronomy Foundation". www.imss.nl. Retrieved 2020-12-18.
  19. ^ Redactie (2019-03-27). "Uitreiking Brightlands Convention Award 2018". Conference Matters (in Dutch). Retrieved 2020-12-18.
  20. ^ "Society for Histochemistry". www.histochemistry.eu. Retrieved 2020-12-18.
  21. ^ "Press release: Omics2Image wins Venture Challenge Spring 2013" (PDF).
  22. ^ "iDirector interview with Ron Heeren - YouTube". www.youtube.com. 28 June 2012. Retrieved 2020-12-18.
  23. ^ "New EMSL Visiting Scientists Named".
  24. ^ "Rapid Communications in Mass Spectrometry". Wiley Online Library. Retrieved 2020-12-18.
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