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{{Short description|Protein and coding gene in humans}}
{{Infobox_gene}}
{{Infobox_gene}}

'''Galactoside 3(4)-L-fucosyltransferase''' is an [[enzyme]] that in humans is encoded by the ''FUT3'' [[gene]].<ref name="pmid1977660">{{cite journal | vauthors = Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB | title = A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase | journal = Genes & Development | volume = 4 | issue = 8 | pages = 1288–303 | date = Aug 1990 | pmid = 1977660 | pmc = | doi = 10.1101/gad.4.8.1288 }}</ref><ref name="pmid1740457">{{cite journal | vauthors = Weston BW, Nair RP, Larsen RD, Lowe JB | title = Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities | journal = The Journal of Biological Chemistry | volume = 267 | issue = 6 | pages = 4152–60 | date = Feb 1992 | pmid = 1740457 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2525| accessdate = }}</ref>
'''Galactoside 3(4)-L-fucosyltransferase''' is an [[enzyme]] that, in humans, is encoded by the ''FUT3'' [[gene]].<ref name="pmid1977660">{{cite journal | vauthors = Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB | title = A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase | journal = Genes & Development | volume = 4 | issue = 8 | pages = 1288–1303 | date = August 1990 | pmid = 1977660 | doi = 10.1101/gad.4.8.1288 | doi-access = free }}</ref><ref name="pmid1740457">{{cite journal | vauthors = Weston BW, Nair RP, Larsen RD, Lowe JB | title = Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities | journal = The Journal of Biological Chemistry | volume = 267 | issue = 6 | pages = 4152–4160 | date = February 1992 | doi = 10.1016/S0021-9258(19)50641-X | pmid = 1740457 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2525 }}</ref>


== Function ==
== Function ==
The [[Lewis blood-group system|Lewis histo-blood group system]] comprises a set of fucosylated glycosphingolipids synthesized by exocrine epithelial cells and circulating in body fluids. These glycosphingolipids play essential roles in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed onto red blood cells, giving rise to the Lewis phenotype.


The [[Lewis blood-group system|Lewis histo-blood group system]] comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.<ref name="entrez" />
This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides during the final step of Lewis antigen biosynthesis. It encodes an enzyme with both alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for most Lewis antigen-negative phenotypes. Multiple alternatively spliced variants encoding the same protein have been identified for this gene.<ref name="entrez" />


== See also ==
== See also ==
Line 14: Line 17:
== Further reading ==
== Further reading ==
{{refbegin|35em}}
{{refbegin|35em}}
* {{cite journal | vauthors = Cameron HS, Szczepaniak D, Weston BW | title = Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms | journal = The Journal of Biological Chemistry | volume = 270 | issue = 34 | pages = 20112–22 | date = Aug 1995 | pmid = 7650030 | doi = 10.1074/jbc.270.34.20112 }}
* {{cite journal | vauthors = Cameron HS, Szczepaniak D, Weston BW | title = Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms | journal = The Journal of Biological Chemistry | volume = 270 | issue = 34 | pages = 20112–22 | date = Aug 1995 | pmid = 7650030 | doi = 10.1074/jbc.270.34.20112 | doi-access = free }}
* {{cite journal | vauthors = Reguigne-Arnould I, Couillin P, Mollicone R, Fauré S, Fletcher A, Kelly RJ, Lowe JB, Oriol R | title = Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19 | journal = Cytogenetics and Cell Genetics | volume = 71 | issue = 2 | pages = 158–62 | year = 1995 | pmid = 7656588 | doi = 10.1159/000134098 }}
* {{cite journal | vauthors = Reguigne-Arnould I, Couillin P, Mollicone R, Fauré S, Fletcher A, Kelly RJ, Lowe JB, Oriol R | title = Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19 | journal = Cytogenetics and Cell Genetics | volume = 71 | issue = 2 | pages = 158–62 | year = 1995 | pmid = 7656588 | doi = 10.1159/000134098 }}
* {{cite journal | vauthors = Nishihara S, Nakazato M, Kudo T, Kimura H, Ando T, Narimatsu H | title = Human alpha-1,3 fucosyltransferase (FucT-VI) gene is located at only 13 kb 3' to the Lewis type fucosyltransferase (FucT-III) gene on chromosome 19 | journal = Biochemical and Biophysical Research Communications | volume = 190 | issue = 1 | pages = 42–6 | date = Jan 1993 | pmid = 7916594 | doi = 10.1006/bbrc.1993.1008 }}
* {{cite journal | vauthors = Nishihara S, Nakazato M, Kudo T, Kimura H, Ando T, Narimatsu H | title = Human alpha-1,3 fucosyltransferase (FucT-VI) gene is located at only 13 kb 3' to the Lewis type fucosyltransferase (FucT-III) gene on chromosome 19 | journal = Biochemical and Biophysical Research Communications | volume = 190 | issue = 1 | pages = 42–6 | date = Jan 1993 | pmid = 7916594 | doi = 10.1006/bbrc.1993.1008 }}
* {{cite journal | vauthors = Nishihara S, Narimatsu H, Iwasaki H, Yazawa S, Akamatsu S, Ando T, Seno T, Narimatsu I | title = Molecular genetic analysis of the human Lewis histo-blood group system | journal = The Journal of Biological Chemistry | volume = 269 | issue = 46 | pages = 29271–8 | date = Nov 1994 | pmid = 7961897 | doi = }}
* {{cite journal | vauthors = Nishihara S, Narimatsu H, Iwasaki H, Yazawa S, Akamatsu S, Ando T, Seno T, Narimatsu I | title = Molecular genetic analysis of the human Lewis histo-blood group system | journal = The Journal of Biological Chemistry | volume = 269 | issue = 46 | pages = 29271–8 | date = Nov 1994 | doi = 10.1016/S0021-9258(19)62041-7 | pmid = 7961897 | doi-access = free }}
* {{cite journal | vauthors = Mollicone R, Reguigne I, Kelly RJ, Fletcher A, Watt J, Chatfield S, Aziz A, Cameron HS, Weston BW, Lowe JB | title = Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees | journal = The Journal of Biological Chemistry | volume = 269 | issue = 33 | pages = 20987–94 | date = Aug 1994 | pmid = 8063716 | doi = }}
* {{cite journal | vauthors = Mollicone R, Reguigne I, Kelly RJ, Fletcher A, Watt J, Chatfield S, Aziz A, Cameron HS, Weston BW, Lowe JB | title = Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees | journal = The Journal of Biological Chemistry | volume = 269 | issue = 33 | pages = 20987–94 | date = Aug 1994 | doi = 10.1016/S0021-9258(17)31919-1 | pmid = 8063716 | doi-access = free }}
* {{cite journal | vauthors = Koda Y, Kimura H, Mekada E | title = Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals | journal = Blood | volume = 82 | issue = 9 | pages = 2915–9 | date = Nov 1993 | pmid = 8219240 | doi = }}
* {{cite journal | vauthors = Koda Y, Kimura H, Mekada E | title = Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals | journal = Blood | volume = 82 | issue = 9 | pages = 2915–9 | date = Nov 1993 | pmid = 8219240 | doi = 10.1182/blood.V82.9.2915.2915| doi-access = free }}
* {{cite journal | vauthors = Elmgren A, Rydberg L, Larson G | title = Genotypic heterogeneity among Lewis negative individuals | journal = Biochemical and Biophysical Research Communications | volume = 196 | issue = 2 | pages = 515–20 | date = Oct 1993 | pmid = 8240322 | doi = 10.1006/bbrc.1993.2280 }}
* {{cite journal | vauthors = Elmgren A, Rydberg L, Larson G | title = Genotypic heterogeneity among Lewis negative individuals | journal = Biochemical and Biophysical Research Communications | volume = 196 | issue = 2 | pages = 515–20 | date = Oct 1993 | pmid = 8240322 | doi = 10.1006/bbrc.1993.2280 }}
* {{cite journal | vauthors = Nishihara S, Yazawa S, Iwasaki H, Nakazato M, Kudo T, Ando T, Narimatsu H | title = Alpha (1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals | journal = Biochemical and Biophysical Research Communications | volume = 196 | issue = 2 | pages = 624–31 | date = Oct 1993 | pmid = 8240337 | doi = 10.1006/bbrc.1993.2295 }}
* {{cite journal | vauthors = Nishihara S, Yazawa S, Iwasaki H, Nakazato M, Kudo T, Ando T, Narimatsu H | title = Alpha (1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals | journal = Biochemical and Biophysical Research Communications | volume = 196 | issue = 2 | pages = 624–31 | date = Oct 1993 | pmid = 8240337 | doi = 10.1006/bbrc.1993.2295 }}
* {{cite journal | vauthors = Elmgren A, Börjeson C, Svensson L, Rydberg L, Larson G | title = DNA sequencing and screening for point mutations in the human Lewis (FUT3) gene enables molecular genotyping of the human Lewis blood group system | journal = Vox Sanguinis | volume = 70 | issue = 2 | pages = 97–103 | year = 1996 | pmid = 8801770 | doi = 10.1111/j.1423-0410.1996.tb01300.x }}
* {{cite journal | vauthors = Elmgren A, Börjeson C, Svensson L, Rydberg L, Larson G | title = DNA sequencing and screening for point mutations in the human Lewis (FUT3) gene enables molecular genotyping of the human Lewis blood group system | journal = Vox Sanguinis | volume = 70 | issue = 2 | pages = 97–103 | year = 1996 | pmid = 8801770 | doi = 10.1111/j.1423-0410.1996.tb01300.x | s2cid = 42984604 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
* {{cite journal | vauthors = Orntoft TF, Vestergaard EM, Holmes E, Jakobsen JS, Grunnet N, Mortensen M, Johnson P, Bross P, Gregersen N, Skorstengaard K, Jensen UB, Bolund L, Wolf H | title = Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels | journal = The Journal of Biological Chemistry | volume = 271 | issue = 50 | pages = 32260–8 | date = Dec 1996 | pmid = 8943285 | doi = 10.1074/jbc.271.50.32260 }}
* {{cite journal | vauthors = Orntoft TF, Vestergaard EM, Holmes E, Jakobsen JS, Grunnet N, Mortensen M, Johnson P, Bross P, Gregersen N, Skorstengaard K, Jensen UB, Bolund L, Wolf H | title = Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels | journal = The Journal of Biological Chemistry | volume = 271 | issue = 50 | pages = 32260–8 | date = Dec 1996 | pmid = 8943285 | doi = 10.1074/jbc.271.50.32260 | doi-access = free }}
* {{cite journal | vauthors = Elmgren A, Mollicone R, Costache M, Börjeson C, Oriol R, Harrington J, Larson G | title = Significance of individual point mutations, T202C and C314T, in the human Lewis (FUT3) gene for expression of Lewis antigens by the human alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII | journal = The Journal of Biological Chemistry | volume = 272 | issue = 35 | pages = 21994–8 | date = Aug 1997 | pmid = 9268337 | doi = 10.1074/jbc.272.35.21994 }}
* {{cite journal | vauthors = Elmgren A, Mollicone R, Costache M, Börjeson C, Oriol R, Harrington J, Larson G | title = Significance of individual point mutations, T202C and C314T, in the human Lewis (FUT3) gene for expression of Lewis antigens by the human alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII | journal = The Journal of Biological Chemistry | volume = 272 | issue = 35 | pages = 21994–8 | date = Aug 1997 | pmid = 9268337 | doi = 10.1074/jbc.272.35.21994 | doi-access =free }}
* {{cite journal | vauthors = Pang H, Liu Y, Koda Y, Soejima M, Jia J, Schlaphoff T, Du Toit ED, Kimura H | title = Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa | journal = Human Genetics | volume = 102 | issue = 6 | pages = 675–80 | date = Jun 1998 | pmid = 9703429 | doi = 10.1007/s004390050760 }}
* {{cite journal | vauthors = Pang H, Liu Y, Koda Y, Soejima M, Jia J, Schlaphoff T, Du Toit ED, Kimura H | title = Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa | journal = Human Genetics | volume = 102 | issue = 6 | pages = 675–80 | date = Jun 1998 | pmid = 9703429 | doi = 10.1007/s004390050760 | s2cid = 12651016 }}
* {{cite journal | vauthors = Nishihara S, Hiraga T, Ikehara Y, Iwasaki H, Kudo T, Yazawa S, Morozumi K, Suda Y, Narimatsu H | title = Molecular behavior of mutant Lewis enzymes in vivo | journal = Glycobiology | volume = 9 | issue = 4 | pages = 373–82 | date = Apr 1999 | pmid = 10089211 | doi = 10.1093/glycob/9.4.373 }}
* {{cite journal | vauthors = Nishihara S, Hiraga T, Ikehara Y, Iwasaki H, Kudo T, Yazawa S, Morozumi K, Suda Y, Narimatsu H | title = Molecular behavior of mutant Lewis enzymes in vivo | journal = Glycobiology | volume = 9 | issue = 4 | pages = 373–82 | date = Apr 1999 | pmid = 10089211 | doi = 10.1093/glycob/9.4.373 | doi-access = free }}
* {{cite journal | vauthors = Yazawa S, Tanaka S, Nishimura T, Miyanaga K, Kochibe N | title = Plasma alpha1,3-fucosyltransferase deficiency in schizophrenia | journal = Experimental and Clinical Immunogenetics | volume = 16 | issue = 3 | pages = 125–30 | year = 1999 | pmid = 10394050 | doi = 10.1159/000019104 }}
* {{cite journal | vauthors = Yazawa S, Tanaka S, Nishimura T, Miyanaga K, Kochibe N | title = Plasma alpha1,3-fucosyltransferase deficiency in schizophrenia | journal = Experimental and Clinical Immunogenetics | volume = 16 | issue = 3 | pages = 125–30 | year = 1999 | pmid = 10394050 | doi = 10.1159/000019104 | s2cid = 85281056 }}
* {{cite journal | vauthors = Holmes EH, Yen TY, Thomas S, Joshi R, Nguyen A, Long T, Gallet F, Maftah A, Julien R, Macher BA | title = Human alpha 1,3/4 fucosyltransferases. Characterization of highly conserved cysteine residues and N-linked glycosylation sites | journal = The Journal of Biological Chemistry | volume = 275 | issue = 32 | pages = 24237–45 | date = Aug 2000 | pmid = 10816554 | doi = 10.1074/jbc.M000888200 }}
* {{cite journal | vauthors = Holmes EH, Yen TY, Thomas S, Joshi R, Nguyen A, Long T, Gallet F, Maftah A, Julien R, Macher BA | title = Human alpha 1,3/4 fucosyltransferases. Characterization of highly conserved cysteine residues and N-linked glycosylation sites | journal = The Journal of Biological Chemistry | volume = 275 | issue = 32 | pages = 24237–45 | date = Aug 2000 | pmid = 10816554 | doi = 10.1074/jbc.M000888200 | doi-access = free }}
* {{cite journal | vauthors = Grahn A, Elmgren A, Aberg L, Svensson L, Jansson PA, Lönnroth P, Larson G | title = Determination of Lewis FUT3 gene mutations by PCR using sequence-specific primers enables efficient genotyping of clinical samples | journal = Human Mutation | volume = 18 | issue = 4 | pages = 358–9 | date = Oct 2001 | pmid = 11668626 | doi = 10.1002/humu.1204 }}
* {{cite journal | vauthors = Grahn A, Elmgren A, Aberg L, Svensson L, Jansson PA, Lönnroth P, Larson G | title = Determination of Lewis FUT3 gene mutations by PCR using sequence-specific primers enables efficient genotyping of clinical samples | journal = Human Mutation | volume = 18 | issue = 4 | pages = 358–9 | date = Oct 2001 | pmid = 11668626 | doi = 10.1002/humu.1204 | s2cid = 33547478 | doi-access = }}
* {{cite journal | vauthors = Roos C, Kolmer M, Mattila P, Renkonen R | title = Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism | journal = The Journal of Biological Chemistry | volume = 277 | issue = 5 | pages = 3168–75 | date = Feb 2002 | pmid = 11698403 | doi = 10.1074/jbc.M107927200 }}
* {{cite journal | vauthors = Roos C, Kolmer M, Mattila P, Renkonen R | title = Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism | journal = The Journal of Biological Chemistry | volume = 277 | issue = 5 | pages = 3168–75 | date = Feb 2002 | pmid = 11698403 | doi = 10.1074/jbc.M107927200 | doi-access = free }}
{{refend}}
{{refend}}


Latest revision as of 12:56, 7 December 2024

FUT3
Identifiers
AliasesFUT3, CD174, FT3B, FucT-III, LE, Les, Fucosyltransferase 3, fucosyltransferase 3 (Lewis blood group)
External IDsHomoloGene: 128031; GeneCards: FUT3; OMA:FUT3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

2525

n/a

Ensembl

ENSG00000171124

n/a

UniProt

P21217

n/a

RefSeq (mRNA)

NM_000149
NM_001097639
NM_001097640
NM_001097641
NM_001374740

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 19: 5.84 – 5.85 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Galactoside 3(4)-L-fucosyltransferase is an enzyme that, in humans, is encoded by the FUT3 gene.[3][4][5]

Function

[edit]

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids synthesized by exocrine epithelial cells and circulating in body fluids. These glycosphingolipids play essential roles in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed onto red blood cells, giving rise to the Lewis phenotype.

This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides during the final step of Lewis antigen biosynthesis. It encodes an enzyme with both alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for most Lewis antigen-negative phenotypes. Multiple alternatively spliced variants encoding the same protein have been identified for this gene.[5]

See also

[edit]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171124 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB (August 1990). "A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase". Genes & Development. 4 (8): 1288–1303. doi:10.1101/gad.4.8.1288. PMID 1977660.
  4. ^ Weston BW, Nair RP, Larsen RD, Lowe JB (February 1992). "Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities". The Journal of Biological Chemistry. 267 (6): 4152–4160. doi:10.1016/S0021-9258(19)50641-X. PMID 1740457.
  5. ^ a b "Entrez Gene: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)".

Further reading

[edit]
[edit]
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