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{{Short description|Neurosurgeon at Mount Sinai Hospital}}
{{unreferenced|date=June 2014}}
{{multiple issues|
'''Isabelle M. Germano''' is a neurosurgeon and Tenured Professor of Neurosurgery, Neurology, and Oncological Sciences at the Icahn School of Medicine at Mount Sinai, in New York City. She is a fellow of the American College of Surgeons and American Associations of Neurological Surgeons. She is also a noted author.
{{more footnotes needed|date=June 2014}}
{{peacock|date=March 2015}}
{{BLP one source|date=July 2016}}
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'''Isabelle M. Germano''' is a neurosurgeon and professor of [[neurosurgery]], [[neurology]], and [[oncology]] at the [[Icahn School of Medicine]] at [[Mount Sinai Hospital (Manhattan)|Mount Sinai Hospital]]. She is a [[Fellow of the American College of Surgeons|Fellow]] of the [[American College of Surgeons]] and the [[American Association of Neurological Surgeons]]. Germano works with image-guided brain and spine surgery.


==Education and post-doctoral training==
==Education and post-doctoral training==
After an undergraduate education with concentration in Latin and ancient Greek literature, she graduated from the [[University of Turin]] Medical School in 1984 with a thesis in neuro-pathology, and also completed a neurology residency. She completed her surgical internship at the [[University of California San Francisco]] and neurosurgery residency at UCSF and the [[Albert Einstein College of Medicine]]. During her residency, she obtained training in epilepsy surgery at the [[University Hospital of Zürich]], Switzerland. After her chief resident year, she completed a fellowship in epilepsy surgery, stereotactic treatments and movement disorders under André Olivier at [[Montreal Neurological Institute]].<ref name="education">{{cite web|title=Isabelle M Germano, MD|url=http://www.mountsinai.org/profiles/isabelle-m-germano|website=Mount Sinai|accessdate=21 July 2016}}</ref>


==Professional career==
After an undergraduate education with concentration in Latin and Ancient Greek Literature, in 1984 Germano graduated valedictorian from the University of Turin Medical School with Summa Cum Laude and a graduate thesis in neuro-pathology, where she also completed a neurology residency.
Germano joined the neurosurgery faculty at Mount Sinai in 1992 to develop the brain tumor and [[stereotactic surgery|stereotactic]] clinical programs. She is the director of the [[comprehensive cancer center|comprehensive]] tumor program and co-director of the [[radiosurgery]] program there. She has worked in the field of image-guided brain and spine surgery<ref>{{Cite book |last1=Aufses, Jr. |first1=Arthur H. |url=https://archive.today/20140616185337/https://nyupress.org/books/book-details.aspx?bookid=8982%23.U582QvldWSo#.U582QvldWSo |title=This House of Noble Deeds The Mount Sinai Hospital, 1852-2002 |last2=Niss |first2=Barbara |date=2002 |publisher=NYU Press |isbn=9780814705001}}</ref> developing new technology for several years and for the last 10 years directed a practical course for neurosurgeons around the world to teach about it until it became standard-of-care. These technological advances are used to perform minimally invasive surgery for patients with [[brain tumor]]s, [[epilepsy]], [[Parkinson's disease]], [[movement disorder]]s, and [[spine disease]] or tumors. Germano established a basic science laboratory within the neurosurgery department to focus on brain tumors translational research with particular emphasis on gene therapy, stem cells, and induced [[pluripotent stem cell]]s (iPSC).<ref>{{Cite journal |last=Bahie Izzat, Tiront Young, Alex Schupper |first=Isabelle Germano |date=July 2024 |title=Molecular profile and clinical outcome of adult primary spinal cord glioblastoma |url=https://www.researchgate.net/profile/Isabelle-Germano |journal=Journal of Neurosurgery: Spine |volume=41 |issue=1 |via=Research Gate - Journal of neurosurgery}}</ref>
Germano completed her surgical internship at the University of California San Francisco and neurosurgery residency at University of California San Francisco and Albert Einstein College of Medicine. During her residency she obtained training in epilepsy surgery under dr. Gazi Yasargil and H. Gregor Wieser at the University Hospital of Zurich, Switzerland. After her Chief resident year, she completed a fellowship in epilepsy surgery, stereotaxy, and movement disorders under dr. Andre’ Olivier at Montreal Neurological Institute, Montreal, Canada.
In 1995, Germano was certified by the American Board of Neurological Surgery (ABNS).


A member of many neurosurgery societies and an author, she has served on the executive committee of the [[Congress of Neurological Surgeons]] (CNS), on the board of directors of the [[American Association of Neurological Surgeons]] (AANS), on the executive committee of the AANS/CNS Joint Section on Tumors, as a scientific program member for the AANS, CNS, and the [[American Epilepsy Society]] (AES).<ref name="education"/> She is a past-president of [[Women in Neurosurgery]] (WINS).<ref name="WFNS">{{cite web|title=Progress of Women in Neurosurgery|url=http://www.wfns.org/filebin/pdf/Women%20in%20Neurosurgery.pdf|publisher=WFNS|accessdate=21 July 2016|archive-url=https://web.archive.org/web/20160816153058/http://www.wfns.org/filebin/pdf/Women%20in%20Neurosurgery.pdf|archive-date=2016-08-16|url-status=dead}}</ref> Germano’s clinical interests include newly diagnosed or recurrent brain and spine tumors, [[brain mapping]] and monitoring, [[glioma]]s, [[metastasis]], [[meningioma]]s, brain and spine radiosurgery, epilepsy surgery, and problems of the cervical and lumbar spine.<ref name="education"/>
==Professional Career==


==Honors and awards==
Germano joined the neurosurgery faculty at Mount Sinai in 1992 to develop and the brain tumor and stereotactic clinical programs, where at Mount Sinai Hospital she is the Director of the Comprehensive Tumor Program and Co-director of the Radiosurgery Program. She became one of the US pioneers of image-guided brain and spine surgery [https://nyupress.org/books/book-details.aspx?bookid=8982#.U582QvldWSo] developing new technology and for years 10 directed a practical course for neurosurgeons around the world to teach about it until it become standard-of-care. These technological advances are used to perform minimally invasive surgery for patients with brain tumors, epilepsy, Parkinson's disease, movement disorders, and spine disease or tumors.
* 2000 - Best Doctors of New York Hall of Fame<ref name="ny hall of fame">{{cite news|last1=Smith|first1=Christopher|title=Best Doctors 2000: Hall of Fame|url=http://nymag.com/nymetro/health/bestdoctors/features/3322/|accessdate=21 July 2016|publisher=New York Magazine}}</ref>
Germano established a basic science laboratory within the Department of Neurosurgery funded without interruption by extramural funds, including NIH and FDA. Her laboratory focuses on brain tumors translational research with particular emphasis on gene therapy, stem cells, and induced Pluripotent Stem Cells (iPSC).
* 2014 - Leksell Radiosurgery Award<ref>{{Cite web |title=Tumor Section Award and Lectureship Winners {{!}} Houston, Texas USA {{!}} |url=https://www.tumorsection.org/aans-award-winners/ |access-date=2024-10-16 |website=www.tumorsection.org |language=en-US}}</ref>


==Publications==
A high-ranking member in many neurosurgery societies and a noted author, she has served as an Executive Committee member for the Congress of Neurological Surgeons (CNS), as a Board of Directors member for the American Association of Neurological Surgeons, as an Executive Committee member of the AANS/CNS Joint Section on Tumors, as a scientific program member for the AANS, CNS, and the American Epilepsy Society (AES), and she is Past-president of Women in Neurosurgery (WINS).
Germano’s clinical interests include newly diagnosed or recurrent brain and spine tumors, including primary brain tumors, metastatic brain tumors, brain tumors in eloquent areas, brain mapping and monitoring, gliomas, metastasis, meningiomas, brain and spine radiosurgery, epilepsy surgery, and problems of the cervical and lumbar spine.


==Honors Awards==
===Books===
* '''Germano IM (Editor).''' Advanced Techniques in Image-Guided Brain and Spine surgery. 2002, Thieme Publishers, New York, NY, pages 233 Library of Congress {{ISBN|1-58890-067-3}}
* 2014 - Leksell Radiosurgery Award, American Association of Neurological Surgeons
* '''Germano IM (Editor).''' LINAC and Gamma Knife Radiosurgery. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 295. Library of Congress {{ISBN|1879284707}} [https://openlibrary.org/search?isbn=1879284707]
* 2013 - Technology Development Award Icahn School of Medicine at Mount Sinai
* '''Germano IM (Editor).''' Neurosurgery Treatment of movement Disorders. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 275 Library of Congress {{ISBN|9781879284586}}<ref>{{Cite web |title=LINAC and gamma knife radiosurgery {{!}} WorldCat.org |url=https://search.worldcat.org/title/47280885?oclcNum=47280885 |access-date=2024-10-16 |website=search.worldcat.org |language=en}}</ref>
* 2004 - 2016 Neurological Devices Voting Member Food and Drug Administration (FDA)
* 2008 - 2013 National Institute of Health (NIH) R01 Award
* 2007 - Brain Tumor Research Goldhirsh Foundation
* 2007- Americas Top Doctors Castle Connolly
* 2006 - New York State Certificate of Recognition, Dedication and Service to the Italians Culture and Community, New York State
* 2005 - Certificate of Excellence in Youth Education
* New York City Department of Education and Mount Sinai School of Medicine
* 2000-Best Doctors of New York Hall of Fame
* 2002 - 2006 America's Top Cancer Doctors Castle Connolly
* 2000 - 2006 Best Doctors of New York Castle Connolly
* 2000 - 2006 Top Doctors New York Metro Area Castle Connolly
* 1994 - Mary Putnam Jacobi Award Women's Medical Association of New York City
* 1993 - W. Penfield Award American Epilepsy Society


==Books==
===Papers===
{{overly detailed|section|date=July 2020}}
* Web based pathology assessment in RTOG 98-04. <ref>{{Cite journal |date=2014 |title=Web based pathology assessment in RTOG 98-04 |url=https://jcp.bmj.com/content/jclinpath/early/2014/07/02/jclinpath-2014-202370.full.pdf |journal=Woodward WA}}</ref>
* Mormone E, D’Souza S, Alexeeva V, Bederson M, Germano IM. “Footprint-free” human induced Pluripotent Stem Cell-derived astrocytes for in vivo cell-based therapy. Stem Cells and Dev [in press 2014]. {{PMID|24914471}}
* Douglas AC, Wippold FJ 2nd, Broderick DF, Aiken AH, Amin-Hanjani S, Brown DC, Corey AS, Germano IM, Hadley JA, Jagadeesan BD, Jurgens JS, Kennedy TA, Mechtler LL, Patel ND, Zipfel GJ. ACR Appropriateness Criteria Headache.J Am Coll Radiol. 2014 Jul;11(7):657-67
* Lo SS, Gore EM, Bradley JD, Buatti JM, Germano IM, Ghafoori AP, Henderson MA, Murad GJ, Patchell RA, Patel SH, Robbins JR, Robins HI, Vassil AD, Wippold FJ 2nd, Yunes MJ, Videtic GM. ACR Appropriateness Criteria® Pre-Irradiation Evaluation and Management of Brain Metastases. J Palliat Med. 2014 Jun 27.
* Germano IM and Binello E. Stem cells and gliomas: past, present, and future. J Neuro-Oncology [in press, 2014].
* Binello E, Emdad l, Mormone E, Germano IM. Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade glioma and anti-invasive effects on glioma stem cells. J Neurooncol, 117(2):225-34, 2014. {{PMID|24493576}}
* Barthélemy EJ, Benjamin E, Jean-Pierre MY, Poitevien G, Ernst S, Osborn I, Germano IM. A prospective emergency department-based study of pattern and outcome of neurologic and neurosurgical diseases in Haiti. World Neurosurg. Oct 9. S1878-8750(13)01298-9, 2013 PIMD 24121294
* Binello E, Qadeer ZA, Kothari H, Emdad L,Germano IM. Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization in Vitro. Journal of Cancer, 3:166-174, 2012. {{PMID|22514559}}
* Binello E, Germano IM. Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol, 14:256-265, 2012. {{PMID|22166262}}
* Emdad L, D’Souza, Qadeer ZA, Kothari HP, Germano IM. Efficient Differentiation of Human Embryonic and induced pluripotent Stem Cells into Functional Astrocytes. Stem Cells and Development, 21(3):404-4120, 2012. {{PMID|21631388}}
* Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria: Follow-up and Retreatment of Brain Metastasis. Am J Clin Oncology, 35(3):302-306, 2012. {{PMID|22609733}}
* Binello E and Germano IM. Targeting glioma stem cells: a novel framework for brain tumors. Cancer Sci, 102:1958-1966, 2011. {{PMID|21848914}}
* Binello E, Green S, Germano IM. Radiosurgery for high-grade glioma. Surg Neurol Int, 3(S2) 118-126, 2012. {{PMID|22826815}}
* Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria Follow-up and Retreatment of brain Metastasis. Am J Clin Oncology, 2012 Jun;35(3):302-306. {{PMID|22609733}}
* Emdad L, Qadeer ZA, Bederson LB, Kothari HP, Uzzaman M, Germano IM. Is there a common upstream link for autophagic and apoptotic cell death in human high grade gliomas? Neuro-Oncology, 13(7)725-35, 2011. {{PMID|21727211}}
* Germano IM, Emdad l, Qader Z, Binello E, Uzzaman M. Embryonic stem cell (ESC) –mediated transgene delivery induces growth suppression, apoptosis, radiosensitization, and overcomes temozolomide resistance in malignant gliomas. Cancer Gene Therapy 17(9):664 – 74, 2010. {{PMID|20523363}}.
* Germano IM, Swiss V, Casaccia P. Primary brain Tumors, Neural stem cells, and brain tumor cancer cells: where is the link? Neuro–pharmacology 58(6):903-10, 2010 {{PMID|20045420}}
* Suh JH, Videtic GMM, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell R, Robins HI, Rogers CL, Wolfson AH, wippold FJ, Gaspar LP. ACR appropriateness Criteria: Single brain metastasis. Curr Probl Cancer. 34(3):162-74, 2010 {{PMID|20541055}}
* Germano IM and Binello E. Gene therapy as an adjuvant treatment of malignant gliomas: from bench to bedside. J Neuro-Oncology 93:79-87, 2009. {{PMID|19430884}}
* Binello E, Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology? J Neuro-Oncol 94(1): 145-8, 2009. {{PMID|19199004}}
* Uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology, 11:102-108 2009. {{PMID|18676359}}
* Videtic GMM, Gaspar LE, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Suh JH, Wolfson AH, Wippold FJ. American College of Radiology appropriateness criteria on multiple brain metastases. J Rad Oncol Biol Physics 75:961-965, 2009. {{PMID|19857783}}
* Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope? Cancer Biology and Therapy 7(9): 1341-7, 2008. {{PMID|1879364}}
* Benzil D, Abosch A, Germano IM, Gilmer Holy, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor, R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 109: 367-375, 2008. {{PMID|18759565}}
* Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 106: 646-651, 2007. {{PMID|17432717}}
* Germano IM, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 105:88-95, 2006. {{PMID|16871882}}
* Uzzaman M, Benveniste R, Keller G,Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 19(3) E6, 2005. {{PMID|16190605}}
* Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 103:115-123,2005. {{PMID|16121982}}
* Benveniste R. and Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 63:542-549, 2005. {{PMID|15936381}}
* Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 24: 980-91, 2005. {{PMID|15592527}}
* Germano IM,Gracies JM, Weisz DJ,Tse W,Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson's disease- a double blind 12-month evaluation study. J Neurosurgery 101:36-42, 2004. {{PMID|15255249}}


==References==
* '''Germano IM (Editor).''' Advanced Techniques in Image-Guided Brain and Spine surgery . 2002, Thieme Publishers, New York, NY, pages 233 Library of Congress ISBN1-58890-067-3
{{reflist}}
* '''Germano IM (Editor).''' LINAC and Gamma Knife Radiosurgery. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 295. Library of Congress ISBN 1879284707
* '''Germano IM (Editor).''' Neurosurgery Treatment of movement Disorders. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 275 Library of Congress ISBN 9781879284586


==External links==
* [http://www.mountsinai.org/profiles/isabelle-m-germano Mount Sinai profile]
* [http://www.newsday.com/news/health/device-tested-to-treat-aggressive-brain-tumors-1.4916978 Device tested to treat aggressive brain tumors]
* [https://www.centerfordiagnosticimaging.com/cdi-host-free-patient-education-seminar-childhood-cancers-including-leukemia/ CDI]
* [http://www.jacr.org/article/S1546-1440(14)00163-X/abstract?rss=yes?rss=yes/ ACR Appropriateness Criteria Headache]


{{authority control}}
==External Links==
*[http://www.mountsinai.org Mount Sinai Hospital homepage]
*[http://www.mssm.edu Mount Sinai School of Medicine homepage]
*[http://www.mssm.edu/departments-and-institutes/neurosurgery/about-us/history Mount Sinai Department of Neurosurgery]
*[http://www.newsday.com/news/health/device-tested-to-treat-aggressive-brain-tumors-1.4916978 Device tested to treat aggressive brain tumors]
*[https://nymag.com/nymetro/health/bestdoctors/features/3322 2000-Best Doctors of New York Hall of Fame]
*[https://www.centerfordiagnosticimaging.com/cdi-host-free-patient-education-seminar-childhood-cancers-including-leukemia/ CDI]
*[http://www.jacr.org/article/S1546-1440(14)00163-X/abstract?rss=yes?rss=yes/ ACR Appropriateness Criteria Headache]
*[http://www.abebooks.com/House-Noble-Deeds-Mount-Sinai-Hospital/7499740763/bd Aufses AH and Niss BJ. This house of Nobles deeds, New York University press, NYC, NY 2002]
*[http://www.youtube.com/watch?v=mL84XUaji2U/ Gamma Knife Thalamotomy for Medically-Refractory Tremor in Patients Not Suitable for DBS]

==References==
* Mormone E, D’Souza S, Alexeeva V, Bederson M, Germano IM. “Footprint-free” human induced Pluripotent Stem Cell-derived astrocytes for in vivo cell-based therapy. Stem Cells and Dev [in press 2014] PMID: 24914471
* Germano IM and Binello E. Stem cells and gliomas: past, present, and future. J Neuro-Oncology [in press, 2014]
* Binello E, Emdad l, Mormone E, Germano IM. Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade glioma and anti-invasive effects on glioma stem cells. J Neurooncol, 117(2):225-34, 2014. PMID:24493576
* Barthélemy EJ, Benjamin E, Jean-Pierre MY, Poitevien G, Ernst S, Osborn I, Germano IM. A prospective emergency room-bases study patter and outcome of neurologicall and neurosurgical diseases in Haiti. World Neurosurg. Oct 9. S1878-8750(13)01298-9, 2013 PIMD 24121294
* Binello E, Qadeer ZA, Kothari H, Emdad L,Germano IM. Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization in Vitro. Journal of Cancer, 3:166-174, 2012. PMID: 22514559
* Binello E, Germano IM. Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol, 14:256-265, 2012. PMID: 22166262
* Emdad L, D’Souza, Qadeer ZA, Kothari HP, Germano IM. Efficient Differentiation of Human Embryonic and induced pluripotent Stem Cells into Functional Astrocytes. Stem Cells and Development, 21(3):404-4120, 2012.PMID:21631388
* Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria: Follow-up and Retreatment of Brain Metastasis. Am J Clin Oncology, 35(3):302-306, 2012. PMID 22609733
* Binello E and Germano IM. Targeting glioma stem cells: a novel framework for brain tumors. Cancer Sci, 102:1958-1966, 2011. PMID: 21848914
* Binello E, Green S, Germano IM. Radiosurgery for high-grade glioma. Surg Neurol Int, 3(S2) 118-126, 2012 PMID: 22826815
* Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria Follow-up and Retreatment of brain Metastasis. Am J Clin Oncology, 2012 Jun;35(3):302-306 PMID 22609733
* Emdad L, Qadeer ZA, Bederson LB, Kothari HP, Uzzaman M, Germano IM. Is there a common upstream link for autophagic and apoptotic cell death in human high grade gliomas? Neuro-Oncology, 13(7)725-35, 2011. PMID: 21727211
* Germano IM, Emdad l, Qader Z, Binello E, Uzzaman M. Embryonic stem cell (ESC) –mediated transgene delivery induces growth suppression, apoptosis, radiosensitization, and overcomes temozolomide resistance in malignant gliomas. Cancer Gene Therapy 17(9):664 – 74, 2010. PMID: 20523363.
* Germano IM, Swiss V, Casaccia P. Primary brain Tumors, Neural stem cells, and brain tumor cancer cells: where is the link? Neuro–pharmacology 58(6):903-10, 2010 PMID: 20045420
* Suh JH, Videtic GMM, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell R, Robins HI, Rogers CL, Wolfson AH, wippold FJ, Gaspar LP. ACR appropriateness Criteria: Single brain metastasis. Curr Probl Cancer. 34(3):162-74, 2010 PMID 20541055
* Germano IM and Binello E. Gene therapy as an adjuvant treatment of malignant gliomas: from bench to bedside. J Neuro-Oncology 93:79-87, 2009. PMID: 19430884
* Binello E, Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology? J Neuro-Oncol 94(1): 145-8, 2009. PMID: 19199004
* Uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology, 11:102-108 2009. PMID: 18676359
* Videtic GMM, Gaspar LE, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Suh JH, Wolfson AH, Wippold FJ. American College of Radiology appropriateness criteria on multiple brain metastases. J Rad Oncol Biol Physics 75:961-965, 2009
* PMID 19857783
* Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope? Cancer Biology and Therapy 7(9): 1341-7, 2008. PMID: 1879364
* Benzil D, Abosch A, Germano IM, Gilmer Holy, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor, R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 109: 367-375, 2008 PMID 18759565
* Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 106: 646-651, 2007. PMID: 17432717
* Germano IM, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 105:88-95, 2006. PMID: 16871882
* Uzzaman M, Benveniste R, Keller G,Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 19(3) E6, 2005. PMID: 16190605
* Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 103:115-123,2005. PMID: 16121982
* Benveniste R. and Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 63:542-549, 2005 PMID: 15936381
* Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 24: 980-91, 2005. PMID15592527
* Germano IM,Gracies JM, Weisz DJ,Tse W,Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson's disease- a double blind 12-month evaluation study. J Neurosurgery 101:36-42, 2004. PMID15255249

<references />


{{DEFAULTSORT:Germano, Isabelle M.}}
[[Category:Medical Imaging]]
[[Category:University of Turin Medical School Alumni]]
[[Category:Medical imaging]]
[[Category:Neurosurgeons]]
[[Category:University of Turin alumni]]
[[Category:Icahn School of Medicine at Mount Sinai faculty]]
[[Category:American medical writers]]
[[Category:Women medical writers]]
[[Category:Living people]]
[[Category:Women surgeons]]
[[Category:Year of birth missing (living people)]]

Revision as of 03:29, 15 December 2024

Isabelle M. Germano is a neurosurgeon and professor of neurosurgery, neurology, and oncology at the Icahn School of Medicine at Mount Sinai Hospital. She is a Fellow of the American College of Surgeons and the American Association of Neurological Surgeons. Germano works with image-guided brain and spine surgery.

Education and post-doctoral training

After an undergraduate education with concentration in Latin and ancient Greek literature, she graduated from the University of Turin Medical School in 1984 with a thesis in neuro-pathology, and also completed a neurology residency. She completed her surgical internship at the University of California San Francisco and neurosurgery residency at UCSF and the Albert Einstein College of Medicine. During her residency, she obtained training in epilepsy surgery at the University Hospital of Zürich, Switzerland. After her chief resident year, she completed a fellowship in epilepsy surgery, stereotactic treatments and movement disorders under André Olivier at Montreal Neurological Institute.[1]

Professional career

Germano joined the neurosurgery faculty at Mount Sinai in 1992 to develop the brain tumor and stereotactic clinical programs. She is the director of the comprehensive tumor program and co-director of the radiosurgery program there. She has worked in the field of image-guided brain and spine surgery[2] developing new technology for several years and for the last 10 years directed a practical course for neurosurgeons around the world to teach about it until it became standard-of-care. These technological advances are used to perform minimally invasive surgery for patients with brain tumors, epilepsy, Parkinson's disease, movement disorders, and spine disease or tumors. Germano established a basic science laboratory within the neurosurgery department to focus on brain tumors translational research with particular emphasis on gene therapy, stem cells, and induced pluripotent stem cells (iPSC).[3]

A member of many neurosurgery societies and an author, she has served on the executive committee of the Congress of Neurological Surgeons (CNS), on the board of directors of the American Association of Neurological Surgeons (AANS), on the executive committee of the AANS/CNS Joint Section on Tumors, as a scientific program member for the AANS, CNS, and the American Epilepsy Society (AES).[1] She is a past-president of Women in Neurosurgery (WINS).[4] Germano’s clinical interests include newly diagnosed or recurrent brain and spine tumors, brain mapping and monitoring, gliomas, metastasis, meningiomas, brain and spine radiosurgery, epilepsy surgery, and problems of the cervical and lumbar spine.[1]

Honors and awards

  • 2000 - Best Doctors of New York Hall of Fame[5]
  • 2014 - Leksell Radiosurgery Award[6]

Publications

Books

  • Germano IM (Editor). Advanced Techniques in Image-Guided Brain and Spine surgery. 2002, Thieme Publishers, New York, NY, pages 233 Library of Congress ISBN 1-58890-067-3
  • Germano IM (Editor). LINAC and Gamma Knife Radiosurgery. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 295. Library of Congress ISBN 1879284707 [1]
  • Germano IM (Editor). Neurosurgery Treatment of movement Disorders. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 275 Library of Congress ISBN 9781879284586[7]

Papers

  • Web based pathology assessment in RTOG 98-04. [8]
  • Mormone E, D’Souza S, Alexeeva V, Bederson M, Germano IM. “Footprint-free” human induced Pluripotent Stem Cell-derived astrocytes for in vivo cell-based therapy. Stem Cells and Dev [in press 2014]. PMID 24914471
  • Douglas AC, Wippold FJ 2nd, Broderick DF, Aiken AH, Amin-Hanjani S, Brown DC, Corey AS, Germano IM, Hadley JA, Jagadeesan BD, Jurgens JS, Kennedy TA, Mechtler LL, Patel ND, Zipfel GJ. ACR Appropriateness Criteria Headache.J Am Coll Radiol. 2014 Jul;11(7):657-67
  • Lo SS, Gore EM, Bradley JD, Buatti JM, Germano IM, Ghafoori AP, Henderson MA, Murad GJ, Patchell RA, Patel SH, Robbins JR, Robins HI, Vassil AD, Wippold FJ 2nd, Yunes MJ, Videtic GM. ACR Appropriateness Criteria® Pre-Irradiation Evaluation and Management of Brain Metastases. J Palliat Med. 2014 Jun 27.
  • Germano IM and Binello E. Stem cells and gliomas: past, present, and future. J Neuro-Oncology [in press, 2014].
  • Binello E, Emdad l, Mormone E, Germano IM. Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade glioma and anti-invasive effects on glioma stem cells. J Neurooncol, 117(2):225-34, 2014. PMID 24493576
  • Barthélemy EJ, Benjamin E, Jean-Pierre MY, Poitevien G, Ernst S, Osborn I, Germano IM. A prospective emergency department-based study of pattern and outcome of neurologic and neurosurgical diseases in Haiti. World Neurosurg. Oct 9. S1878-8750(13)01298-9, 2013 PIMD 24121294
  • Binello E, Qadeer ZA, Kothari H, Emdad L,Germano IM. Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization in Vitro. Journal of Cancer, 3:166-174, 2012. PMID 22514559
  • Binello E, Germano IM. Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol, 14:256-265, 2012. PMID 22166262
  • Emdad L, D’Souza, Qadeer ZA, Kothari HP, Germano IM. Efficient Differentiation of Human Embryonic and induced pluripotent Stem Cells into Functional Astrocytes. Stem Cells and Development, 21(3):404-4120, 2012. PMID 21631388
  • Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria: Follow-up and Retreatment of Brain Metastasis. Am J Clin Oncology, 35(3):302-306, 2012. PMID 22609733
  • Binello E and Germano IM. Targeting glioma stem cells: a novel framework for brain tumors. Cancer Sci, 102:1958-1966, 2011. PMID 21848914
  • Binello E, Green S, Germano IM. Radiosurgery for high-grade glioma. Surg Neurol Int, 3(S2) 118-126, 2012. PMID 22826815
  • Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria Follow-up and Retreatment of brain Metastasis. Am J Clin Oncology, 2012 Jun;35(3):302-306. PMID 22609733
  • Emdad L, Qadeer ZA, Bederson LB, Kothari HP, Uzzaman M, Germano IM. Is there a common upstream link for autophagic and apoptotic cell death in human high grade gliomas? Neuro-Oncology, 13(7)725-35, 2011. PMID 21727211
  • Germano IM, Emdad l, Qader Z, Binello E, Uzzaman M. Embryonic stem cell (ESC) –mediated transgene delivery induces growth suppression, apoptosis, radiosensitization, and overcomes temozolomide resistance in malignant gliomas. Cancer Gene Therapy 17(9):664 – 74, 2010. PMID 20523363.
  • Germano IM, Swiss V, Casaccia P. Primary brain Tumors, Neural stem cells, and brain tumor cancer cells: where is the link? Neuro–pharmacology 58(6):903-10, 2010 PMID 20045420
  • Suh JH, Videtic GMM, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell R, Robins HI, Rogers CL, Wolfson AH, wippold FJ, Gaspar LP. ACR appropriateness Criteria: Single brain metastasis. Curr Probl Cancer. 34(3):162-74, 2010 PMID 20541055
  • Germano IM and Binello E. Gene therapy as an adjuvant treatment of malignant gliomas: from bench to bedside. J Neuro-Oncology 93:79-87, 2009. PMID 19430884
  • Binello E, Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology? J Neuro-Oncol 94(1): 145-8, 2009. PMID 19199004
  • Uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology, 11:102-108 2009. PMID 18676359
  • Videtic GMM, Gaspar LE, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Suh JH, Wolfson AH, Wippold FJ. American College of Radiology appropriateness criteria on multiple brain metastases. J Rad Oncol Biol Physics 75:961-965, 2009. PMID 19857783
  • Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope? Cancer Biology and Therapy 7(9): 1341-7, 2008. PMID 1879364
  • Benzil D, Abosch A, Germano IM, Gilmer Holy, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor, R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 109: 367-375, 2008. PMID 18759565
  • Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 106: 646-651, 2007. PMID 17432717
  • Germano IM, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 105:88-95, 2006. PMID 16871882
  • Uzzaman M, Benveniste R, Keller G,Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 19(3) E6, 2005. PMID 16190605
  • Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 103:115-123,2005. PMID 16121982
  • Benveniste R. and Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 63:542-549, 2005. PMID 15936381
  • Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 24: 980-91, 2005. PMID 15592527
  • Germano IM,Gracies JM, Weisz DJ,Tse W,Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson's disease- a double blind 12-month evaluation study. J Neurosurgery 101:36-42, 2004. PMID 15255249

References

  1. ^ a b c "Isabelle M Germano, MD". Mount Sinai. Retrieved 21 July 2016.
  2. ^ Aufses, Jr., Arthur H.; Niss, Barbara (2002). This House of Noble Deeds The Mount Sinai Hospital, 1852-2002. NYU Press. ISBN 9780814705001.
  3. ^ Bahie Izzat, Tiront Young, Alex Schupper, Isabelle Germano (July 2024). "Molecular profile and clinical outcome of adult primary spinal cord glioblastoma". Journal of Neurosurgery: Spine. 41 (1) – via Research Gate - Journal of neurosurgery.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ "Progress of Women in Neurosurgery" (PDF). WFNS. Archived from the original (PDF) on 2016-08-16. Retrieved 21 July 2016.
  5. ^ Smith, Christopher. "Best Doctors 2000: Hall of Fame". New York Magazine. Retrieved 21 July 2016.
  6. ^ "Tumor Section Award and Lectureship Winners | Houston, Texas USA |". www.tumorsection.org. Retrieved 2024-10-16.
  7. ^ "LINAC and gamma knife radiosurgery | WorldCat.org". search.worldcat.org. Retrieved 2024-10-16.
  8. ^ "Web based pathology assessment in RTOG 98-04" (PDF). Woodward WA. 2014.
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