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{{Short description|Neurosurgeon at Mount Sinai Hospital}}
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'''Isabelle M. Germano''' is a neurosurgeon and a tenured professor of [[neurosurgery]], [[neurology]], and [[oncology]] at the [[Icahn School of Medicine]] at [[Mount Sinai Hospital (Manhattan)|Mount Sinai Hospital]], in New York City. She is a [[FACS|Fellow]] of the [[American College of Surgeons]] and the [[American Association of Neurological Surgeons]]. She is also an author. Germano has worked in image-guided brain and spine surgery.
'''Isabelle M. Germano''' is a neurosurgeon and professor of [[neurosurgery]], [[neurology]], and [[oncology]] at the [[Icahn School of Medicine]] at [[Mount Sinai Hospital (Manhattan)|Mount Sinai Hospital]]. She is a [[Fellow of the American College of Surgeons|Fellow]] of the [[American College of Surgeons]] and the [[American Association of Neurological Surgeons]]. Germano works with image-guided brain and spine surgery.


==Education and post-doctoral training==
==Education and post-doctoral training==
After an undergraduate education with concentration in Latin and ancient Greek literature, in 1984 she graduated from the [[University of Turin Medical School]] with a graduate thesis in neuro-pathology, where she also completed a neurology residency. She completed her surgical internship at the [[University of California San Francisco]] and neurosurgery residency at UCSF and the [[Albert Einstein College of Medicine]]. During her residency she obtained training in epilepsy surgery at the [[University Hospital of Zurich]], Switzerland. After her chief resident year, she completed a fellowship in epilepsy surgery, stereotaxy, and movement disorders under André Olivier at [[Montreal Neurological Institute]].<ref name="education">{{cite web|title=Isabelle M Germano, MD|url=http://www.mountsinai.org/profiles/isabelle-m-germano|website=Mount Sinai|publisher=Mount Sinai|accessdate=21 July 2016}}</ref>
After an undergraduate education with concentration in Latin and ancient Greek literature, she graduated from the [[University of Turin]] Medical School in 1984 with a thesis in neuro-pathology, and also completed a neurology residency. She completed her surgical internship at the [[University of California San Francisco]] and neurosurgery residency at UCSF and the [[Albert Einstein College of Medicine]]. During her residency, she obtained training in epilepsy surgery at the [[University Hospital of Zürich]], Switzerland. After her chief resident year, she completed a fellowship in epilepsy surgery, stereotactic treatments and movement disorders under André Olivier at [[Montreal Neurological Institute]].<ref name="education">{{cite web|title=Isabelle M Germano, MD|url=http://www.mountsinai.org/profiles/isabelle-m-germano|website=Mount Sinai|accessdate=21 July 2016}}</ref>


==Professional career==
==Professional career==
Germano joined the neurosurgery faculty at Mount Sinai in 1992 to develop the brain tumor and [[stereotactic surgery|stereotactic]] clinical programs. She is the director of the [[comprehensive tumor]] program and co-director of the [[radiosurgery]] program there. She has worked in the field of image-guided brain and spine surgery [https://nyupress.org/books/book-details.aspx?bookid=8982#.U582QvldWSo]{{deadlink|date=July 2016}} developing new technology for several years and for the last 10 years directed a practical course for neurosurgeons around the world to teach about it until it become standard-of-care. These technological advances are used to perform minimally invasive surgery for patients with [[brain tumor]]s, [[epilepsy]], [[Parkinson's disease]], [[movement disorder]]s, and [[spine disease]] or tumors.
Germano joined the neurosurgery faculty at Mount Sinai in 1992 to develop the brain tumor and [[stereotactic surgery|stereotactic]] clinical programs. She is the director of the [[comprehensive cancer center|comprehensive]] tumor program and co-director of the [[radiosurgery]] program there. She has worked in the field of image-guided brain and spine surgery<ref>{{Cite book |last1=Aufses, Jr. |first1=Arthur H. |url=https://archive.today/20140616185337/https://nyupress.org/books/book-details.aspx?bookid=8982%23.U582QvldWSo#.U582QvldWSo |title=This House of Noble Deeds The Mount Sinai Hospital, 1852-2002 |last2=Niss |first2=Barbara |date=2002 |publisher=NYU Press |isbn=9780814705001}}</ref> developing new technology for several years and for the last 10 years directed a practical course for neurosurgeons around the world to teach about it until it became standard-of-care. These technological advances are used to perform minimally invasive surgery for patients with [[brain tumor]]s, [[epilepsy]], [[Parkinson's disease]], [[movement disorder]]s, and [[spine disease]] or tumors. Germano established a basic science laboratory within the neurosurgery department to focus on brain tumors translational research with particular emphasis on gene therapy, stem cells, and induced [[pluripotent stem cell]]s (iPSC).<ref>{{Cite journal |last=Bahie Izzat, Tiront Young, Alex Schupper |first=Isabelle Germano |date=July 2024 |title=Molecular profile and clinical outcome of adult primary spinal cord glioblastoma |url=https://www.researchgate.net/profile/Isabelle-Germano |journal=Journal of Neurosurgery: Spine |volume=41 |issue=1 |via=Research Gate - Journal of neurosurgery}}</ref>
Germano established a basic science laboratory within the neurosurgery department to focus on brain tumors translational research with particular emphasis on gene therapy, stem cells, and induced [[pluripotent stem cell]]s (iPSC).


A member in many neurosurgery societies and an author, she has served on the executive committee of the [[Congress of Neurological Surgeons]] (CNS), on the board of directors of the [[American Association of Neurological Surgeons]] (AANS), on the executive committee of the AANS/CNS Joint Section on Tumors, as a scientific program member for the AANS, CNS, and the [[American Epilepsy Society]] (AES).<ref name="education"/> She is a past-president of [[Women in Neurosurgery]] (WINS).<ref name="WFNS">{{cite web|title=Progress of Women in Neurosurgery|url=http://www.wfns.org/filebin/pdf/Women%20in%20Neurosurgery.pdf|publisher=WFNS|accessdate=21 July 2016}}</ref>
A member of many neurosurgery societies and an author, she has served on the executive committee of the [[Congress of Neurological Surgeons]] (CNS), on the board of directors of the [[American Association of Neurological Surgeons]] (AANS), on the executive committee of the AANS/CNS Joint Section on Tumors, as a scientific program member for the AANS, CNS, and the [[American Epilepsy Society]] (AES).<ref name="education"/> She is a past-president of [[Women in Neurosurgery]] (WINS).<ref name="WFNS">{{cite web|title=Progress of Women in Neurosurgery|url=http://www.wfns.org/filebin/pdf/Women%20in%20Neurosurgery.pdf|publisher=WFNS|accessdate=21 July 2016|archive-url=https://web.archive.org/web/20160816153058/http://www.wfns.org/filebin/pdf/Women%20in%20Neurosurgery.pdf|archive-date=2016-08-16|url-status=dead}}</ref> Germano’s clinical interests include newly diagnosed or recurrent brain and spine tumors, [[brain mapping]] and monitoring, [[glioma]]s, [[metastasis]], [[meningioma]]s, brain and spine radiosurgery, epilepsy surgery, and problems of the cervical and lumbar spine.<ref name="education"/>
Germano’s clinical interests include newly diagnosed or recurrent brain and spine tumors, including primary brain tumors, metastatic brain tumors, brain tumors in [[eloquent area]]s{{clarify|date=July 2016}}, [[brain mapping]] and monitoring, [[glioma]]s, [[metastasis]], [[meningioma]]s, brain and spine radiosurgery, epilepsy surgery, and problems of the cervical and lumbar spine.<ref name="education"/>

Germano has written several articles and papers.<ref>[http://academic.research.microsoft.com/Author/24377987/isabelle-m-germano Isabelle Germano] publications at Microsoft Academia</ref><ref>[https://scholar.google.com/scholar?q=%22isabelle+M.+germano%22&btnG=&hl=en&as_sdt=0%2C33/ Isabelle M. Germano] publications at Google Scholar</ref>


==Honors and awards==
==Honors and awards==
* 2000 - Best Doctors of New York Hall of Fame<ref name="ny hall of fame">{{cite news|last1=Smith|first1=Christopher|title=Best Doctors 2000: Hall of Fame|url=http://nymag.com/nymetro/health/bestdoctors/features/3322/|accessdate=21 July 2016|publisher=New York Magazine}}</ref>
* 2000 - Best Doctors of New York Hall of Fame<ref name="ny hall of fame">{{cite news|last1=Smith|first1=Christopher|title=Best Doctors 2000: Hall of Fame|url=http://nymag.com/nymetro/health/bestdoctors/features/3322/|accessdate=21 July 2016|publisher=New York Magazine}}</ref>
* 2014 - Leksell Radiosurgery Award<ref>{{Cite web |title=Tumor Section Award and Lectureship Winners {{!}} Houston, Texas USA {{!}} |url=https://www.tumorsection.org/aans-award-winners/ |access-date=2024-10-16 |website=www.tumorsection.org |language=en-US}}</ref>

* 2014 - [http://tumorsection.org/aans-award-winners/ Leksell Radiosurgery Award]


==Publications==
==Publications==

===Books===
===Books===
* '''Germano IM (Editor).''' Advanced Techniques in Image-Guided Brain and Spine surgery . 2002, Thieme Publishers, New York, NY, pages 233 Library of Congress ISBN 1-58890-067-3
* '''Germano IM (Editor).''' Advanced Techniques in Image-Guided Brain and Spine surgery. 2002, Thieme Publishers, New York, NY, pages 233 Library of Congress {{ISBN|1-58890-067-3}}
* '''Germano IM (Editor).''' LINAC and Gamma Knife Radiosurgery. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 295. Library of Congress ISBN 1879284707 [https://openlibrary.org/search?isbn=1879284707]
* '''Germano IM (Editor).''' LINAC and Gamma Knife Radiosurgery. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 295. Library of Congress {{ISBN|1879284707}} [https://openlibrary.org/search?isbn=1879284707]
* '''Germano IM (Editor).''' Neurosurgery Treatment of movement Disorders. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 275 Library of Congress ISBN 9781879284586 [https://www.worldcat.org/search?qt=wikipedia&q=isbn%3A1879284707]
* '''Germano IM (Editor).''' Neurosurgery Treatment of movement Disorders. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 275 Library of Congress {{ISBN|9781879284586}}<ref>{{Cite web |title=LINAC and gamma knife radiosurgery {{!}} WorldCat.org |url=https://search.worldcat.org/title/47280885?oclcNum=47280885 |access-date=2024-10-16 |website=search.worldcat.org |language=en}}</ref>


===Papers===
===Papers===
{{overly detailed|section|date=July 2020}}
* Web based pathology assessment in RTOG 98-04 [http://jcp.bmj.com/content/early/2014/07/02/jclinpath-2014-202370.full.pdf/]
* Web based pathology assessment in RTOG 98-04. <ref>{{Cite journal |date=2014 |title=Web based pathology assessment in RTOG 98-04 |url=https://jcp.bmj.com/content/jclinpath/early/2014/07/02/jclinpath-2014-202370.full.pdf |journal=Woodward WA}}</ref>
* Mormone E, D’Souza S, Alexeeva V, Bederson M, Germano IM. “Footprint-free” human induced Pluripotent Stem Cell-derived astrocytes for in vivo cell-based therapy. Stem Cells and Dev [in press 2014] PMID 24914471
* Mormone E, D’Souza S, Alexeeva V, Bederson M, Germano IM. “Footprint-free” human induced Pluripotent Stem Cell-derived astrocytes for in vivo cell-based therapy. Stem Cells and Dev [in press 2014]. {{PMID|24914471}}
* Douglas AC, Wippold FJ 2nd, Broderick DF, Aiken AH, Amin-Hanjani S, Brown DC, Corey AS, Germano IM, Hadley JA, Jagadeesan BD, Jurgens JS, Kennedy TA, Mechtler LL, Patel ND, Zipfel GJ. ACR Appropriateness Criteria Headache.J Am Coll Radiol. 2014 Jul;11(7):657-67
* Douglas AC, Wippold FJ 2nd, Broderick DF, Aiken AH, Amin-Hanjani S, Brown DC, Corey AS, Germano IM, Hadley JA, Jagadeesan BD, Jurgens JS, Kennedy TA, Mechtler LL, Patel ND, Zipfel GJ. ACR Appropriateness Criteria Headache.J Am Coll Radiol. 2014 Jul;11(7):657-67
* Lo SS, Gore EM, Bradley JD, Buatti JM, Germano IM, Ghafoori AP, Henderson MA, Murad GJ, Patchell RA, Patel SH, Robbins JR, Robins HI, Vassil AD, Wippold FJ 2nd, Yunes MJ, Videtic GM. ACR Appropriateness Criteria® Pre-Irradiation Evaluation and Management of Brain Metastases. J Palliat Med. 2014 Jun 27.
* Lo SS, Gore EM, Bradley JD, Buatti JM, Germano IM, Ghafoori AP, Henderson MA, Murad GJ, Patchell RA, Patel SH, Robbins JR, Robins HI, Vassil AD, Wippold FJ 2nd, Yunes MJ, Videtic GM. ACR Appropriateness Criteria® Pre-Irradiation Evaluation and Management of Brain Metastases. J Palliat Med. 2014 Jun 27.
* Germano IM and Binello E. Stem cells and gliomas: past, present, and future. J Neuro-Oncology [in press, 2014]
* Germano IM and Binello E. Stem cells and gliomas: past, present, and future. J Neuro-Oncology [in press, 2014].
* Binello E, Emdad l, Mormone E, Germano IM. Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade glioma and anti-invasive effects on glioma stem cells. J Neurooncol, 117(2):225-34, 2014. PMID 24493576
* Binello E, Emdad l, Mormone E, Germano IM. Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade glioma and anti-invasive effects on glioma stem cells. J Neurooncol, 117(2):225-34, 2014. {{PMID|24493576}}
* Barthélemy EJ, Benjamin E, Jean-Pierre MY, Poitevien G, Ernst S, Osborn I, Germano IM. A prospective emergency department-based study of pattern and outcome of neurologic and neurosurgical diseases in Haiti. World Neurosurg. Oct 9. S1878-8750(13)01298-9, 2013 PIMD 24121294
* Barthélemy EJ, Benjamin E, Jean-Pierre MY, Poitevien G, Ernst S, Osborn I, Germano IM. A prospective emergency department-based study of pattern and outcome of neurologic and neurosurgical diseases in Haiti. World Neurosurg. Oct 9. S1878-8750(13)01298-9, 2013 PIMD 24121294
* Binello E, Qadeer ZA, Kothari H, Emdad L,Germano IM. Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization in Vitro. Journal of Cancer, 3:166-174, 2012. PMID 22514559
* Binello E, Qadeer ZA, Kothari H, Emdad L,Germano IM. Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization in Vitro. Journal of Cancer, 3:166-174, 2012. {{PMID|22514559}}
* Binello E, Germano IM. Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol, 14:256-265, 2012. PMID 22166262
* Binello E, Germano IM. Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol, 14:256-265, 2012. {{PMID|22166262}}
* Emdad L, D’Souza, Qadeer ZA, Kothari HP, Germano IM. Efficient Differentiation of Human Embryonic and induced pluripotent Stem Cells into Functional Astrocytes. Stem Cells and Development, 21(3):404-4120, 2012.PMID 21631388
* Emdad L, D’Souza, Qadeer ZA, Kothari HP, Germano IM. Efficient Differentiation of Human Embryonic and induced pluripotent Stem Cells into Functional Astrocytes. Stem Cells and Development, 21(3):404-4120, 2012. {{PMID|21631388}}
* Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria: Follow-up and Retreatment of Brain Metastasis. Am J Clin Oncology, 35(3):302-306, 2012. PMID 22609733
* Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria: Follow-up and Retreatment of Brain Metastasis. Am J Clin Oncology, 35(3):302-306, 2012. {{PMID|22609733}}
* Binello E and Germano IM. Targeting glioma stem cells: a novel framework for brain tumors. Cancer Sci, 102:1958-1966, 2011. PMID 21848914
* Binello E and Germano IM. Targeting glioma stem cells: a novel framework for brain tumors. Cancer Sci, 102:1958-1966, 2011. {{PMID|21848914}}
* Binello E, Green S, Germano IM. Radiosurgery for high-grade glioma. Surg Neurol Int, 3(S2) 118-126, 2012 PMID 22826815
* Binello E, Green S, Germano IM. Radiosurgery for high-grade glioma. Surg Neurol Int, 3(S2) 118-126, 2012. {{PMID|22826815}}
* Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria Follow-up and Retreatment of brain Metastasis. Am J Clin Oncology, 2012 Jun;35(3):302-306 PMID 22609733
* Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria Follow-up and Retreatment of brain Metastasis. Am J Clin Oncology, 2012 Jun;35(3):302-306. {{PMID|22609733}}
* Emdad L, Qadeer ZA, Bederson LB, Kothari HP, Uzzaman M, Germano IM. Is there a common upstream link for autophagic and apoptotic cell death in human high grade gliomas? Neuro-Oncology, 13(7)725-35, 2011. PMID 21727211
* Emdad L, Qadeer ZA, Bederson LB, Kothari HP, Uzzaman M, Germano IM. Is there a common upstream link for autophagic and apoptotic cell death in human high grade gliomas? Neuro-Oncology, 13(7)725-35, 2011. {{PMID|21727211}}
* Germano IM, Emdad l, Qader Z, Binello E, Uzzaman M. Embryonic stem cell (ESC) –mediated transgene delivery induces growth suppression, apoptosis, radiosensitization, and overcomes temozolomide resistance in malignant gliomas. Cancer Gene Therapy 17(9):664 – 74, 2010. PMID 20523363.
* Germano IM, Emdad l, Qader Z, Binello E, Uzzaman M. Embryonic stem cell (ESC) –mediated transgene delivery induces growth suppression, apoptosis, radiosensitization, and overcomes temozolomide resistance in malignant gliomas. Cancer Gene Therapy 17(9):664 – 74, 2010. {{PMID|20523363}}.
* Germano IM, Swiss V, Casaccia P. Primary brain Tumors, Neural stem cells, and brain tumor cancer cells: where is the link? Neuro–pharmacology 58(6):903-10, 2010 PMID 20045420
* Germano IM, Swiss V, Casaccia P. Primary brain Tumors, Neural stem cells, and brain tumor cancer cells: where is the link? Neuro–pharmacology 58(6):903-10, 2010 {{PMID|20045420}}
* Suh JH, Videtic GMM, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell R, Robins HI, Rogers CL, Wolfson AH, wippold FJ, Gaspar LP. ACR appropriateness Criteria: Single brain metastasis. Curr Probl Cancer. 34(3):162-74, 2010 PMID 20541055
* Suh JH, Videtic GMM, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell R, Robins HI, Rogers CL, Wolfson AH, wippold FJ, Gaspar LP. ACR appropriateness Criteria: Single brain metastasis. Curr Probl Cancer. 34(3):162-74, 2010 {{PMID|20541055}}
* Germano IM and Binello E. Gene therapy as an adjuvant treatment of malignant gliomas: from bench to bedside. J Neuro-Oncology 93:79-87, 2009. PMID 19430884
* Germano IM and Binello E. Gene therapy as an adjuvant treatment of malignant gliomas: from bench to bedside. J Neuro-Oncology 93:79-87, 2009. {{PMID|19430884}}
* Binello E, Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology? J Neuro-Oncol 94(1): 145-8, 2009. PMID 19199004
* Binello E, Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology? J Neuro-Oncol 94(1): 145-8, 2009. {{PMID|19199004}}
* Uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology, 11:102-108 2009. PMID 18676359
* Uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology, 11:102-108 2009. {{PMID|18676359}}
* Videtic GMM, Gaspar LE, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Suh JH, Wolfson AH, Wippold FJ. American College of Radiology appropriateness criteria on multiple brain metastases. J Rad Oncol Biol Physics 75:961-965, 2009
* Videtic GMM, Gaspar LE, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Suh JH, Wolfson AH, Wippold FJ. American College of Radiology appropriateness criteria on multiple brain metastases. J Rad Oncol Biol Physics 75:961-965, 2009. {{PMID|19857783}}
⚫
* Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope? Cancer Biology and Therapy 7(9): 1341-7, 2008. {{PMID|1879364}}
* PMID 19857783
⚫
* Benzil D, Abosch A, Germano IM, Gilmer Holy, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor, R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 109: 367-375, 2008. {{PMID|18759565}}
⚫
* Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope? Cancer Biology and Therapy 7(9): 1341-7, 2008. PMID 1879364
* Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 106: 646-651, 2007. {{PMID|17432717}}
⚫
* Benzil D, Abosch A, Germano IM, Gilmer Holy, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor, R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 109: 367-375, 2008 PMID 18759565
* Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 106: 646-651, 2007. PMID 17432717
* Germano IM, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 105:88-95, 2006. {{PMID|16871882}}
* Germano IM, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 105:88-95, 2006. PMID 16871882
* Uzzaman M, Benveniste R, Keller G,Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 19(3) E6, 2005. {{PMID|16190605}}
* Uzzaman M, Benveniste R, Keller G,Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 19(3) E6, 2005. PMID 16190605
* Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 103:115-123,2005. {{PMID|16121982}}
* Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 103:115-123,2005. PMID 16121982
* Benveniste R. and Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 63:542-549, 2005. {{PMID|15936381}}
⚫
* Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 24: 980-91, 2005. {{PMID|15592527}}
* Benveniste R. and Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 63:542-549, 2005 PMID 15936381
⚫
* Germano IM,Gracies JM, Weisz DJ,Tse W,Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson's disease- a double blind 12-month evaluation study. J Neurosurgery 101:36-42, 2004. {{PMID|15255249}}
⚫
* Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 24: 980-91, 2005. PMID15592527
⚫
* Germano IM,Gracies JM, Weisz DJ,Tse W,Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson's disease- a double blind 12-month evaluation study. J Neurosurgery 101:36-42, 2004. PMID15255249


==References==
==References==
{{reflist}}
{{reflist}}
⚫
*[http://www.newsday.com/news/health/device-tested-to-treat-aggressive-brain-tumors-1.4916978 Device tested to treat aggressive brain tumors]
⚫
*[https://www.centerfordiagnosticimaging.com/cdi-host-free-patient-education-seminar-childhood-cancers-including-leukemia/ CDI]
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*[http://www.jacr.org/article/S1546-1440(14)00163-X/abstract?rss=yes?rss=yes/ ACR Appropriateness Criteria Headache]


==External links==
==External links==
*[http://www.mountsinai.org/profiles/isabelle-m-germano Mount Sinai profile]
* [http://www.mountsinai.org/profiles/isabelle-m-germano Mount Sinai profile]
⚫
* [http://www.newsday.com/news/health/device-tested-to-treat-aggressive-brain-tumors-1.4916978 Device tested to treat aggressive brain tumors]
*2000-Best Doctors of New York Hall of Fame [http://nymag.com/nymetro/health/bestdoctors/features/3322]
⚫
* [https://www.centerfordiagnosticimaging.com/cdi-host-free-patient-education-seminar-childhood-cancers-including-leukemia/ CDI]
⚫
* [http://www.jacr.org/article/S1546-1440(14)00163-X/abstract?rss=yes?rss=yes/ ACR Appropriateness Criteria Headache]

{{authority control}}


{{DEFAULTSORT:Germano, Isabelle M.}}
{{DEFAULTSORT:Germano, Isabelle M.}}
[[Category:Medical imaging]]
[[Category:Medical imaging]]
[[Category:University of Turin alumni]]
[[Category:University of Turin alumni]]
[[Category:American neurosurgeons]]
[[Category:Icahn School of Medicine at Mount Sinai faculty]]
[[Category:Icahn School of Medicine at Mount Sinai faculty]]
[[Category:American medical writers]]
[[Category:American medical writers]]
[[Category:Women medical writers]]
[[Category:Living people]]
[[Category:Living people]]
[[Category:Women surgeons]]
[[Category:Year of birth missing (living people)]]

Latest revision as of 03:29, 15 December 2024

Isabelle M. Germano is a neurosurgeon and professor of neurosurgery, neurology, and oncology at the Icahn School of Medicine at Mount Sinai Hospital. She is a Fellow of the American College of Surgeons and the American Association of Neurological Surgeons. Germano works with image-guided brain and spine surgery.

Education and post-doctoral training

[edit]

After an undergraduate education with concentration in Latin and ancient Greek literature, she graduated from the University of Turin Medical School in 1984 with a thesis in neuro-pathology, and also completed a neurology residency. She completed her surgical internship at the University of California San Francisco and neurosurgery residency at UCSF and the Albert Einstein College of Medicine. During her residency, she obtained training in epilepsy surgery at the University Hospital of Zürich, Switzerland. After her chief resident year, she completed a fellowship in epilepsy surgery, stereotactic treatments and movement disorders under André Olivier at Montreal Neurological Institute.[1]

Professional career

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Germano joined the neurosurgery faculty at Mount Sinai in 1992 to develop the brain tumor and stereotactic clinical programs. She is the director of the comprehensive tumor program and co-director of the radiosurgery program there. She has worked in the field of image-guided brain and spine surgery[2] developing new technology for several years and for the last 10 years directed a practical course for neurosurgeons around the world to teach about it until it became standard-of-care. These technological advances are used to perform minimally invasive surgery for patients with brain tumors, epilepsy, Parkinson's disease, movement disorders, and spine disease or tumors. Germano established a basic science laboratory within the neurosurgery department to focus on brain tumors translational research with particular emphasis on gene therapy, stem cells, and induced pluripotent stem cells (iPSC).[3]

A member of many neurosurgery societies and an author, she has served on the executive committee of the Congress of Neurological Surgeons (CNS), on the board of directors of the American Association of Neurological Surgeons (AANS), on the executive committee of the AANS/CNS Joint Section on Tumors, as a scientific program member for the AANS, CNS, and the American Epilepsy Society (AES).[1] She is a past-president of Women in Neurosurgery (WINS).[4] Germano’s clinical interests include newly diagnosed or recurrent brain and spine tumors, brain mapping and monitoring, gliomas, metastasis, meningiomas, brain and spine radiosurgery, epilepsy surgery, and problems of the cervical and lumbar spine.[1]

Honors and awards

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  • 2000 - Best Doctors of New York Hall of Fame[5]
  • 2014 - Leksell Radiosurgery Award[6]

Publications

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Books

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  • Germano IM (Editor). Advanced Techniques in Image-Guided Brain and Spine surgery. 2002, Thieme Publishers, New York, NY, pages 233 Library of Congress ISBN 1-58890-067-3
  • Germano IM (Editor). LINAC and Gamma Knife Radiosurgery. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 295. Library of Congress ISBN 1879284707 [1]
  • Germano IM (Editor). Neurosurgery Treatment of movement Disorders. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 275 Library of Congress ISBN 9781879284586[7]

Papers

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  • Web based pathology assessment in RTOG 98-04. [8]
  • Mormone E, D’Souza S, Alexeeva V, Bederson M, Germano IM. “Footprint-free” human induced Pluripotent Stem Cell-derived astrocytes for in vivo cell-based therapy. Stem Cells and Dev [in press 2014]. PMID 24914471
  • Douglas AC, Wippold FJ 2nd, Broderick DF, Aiken AH, Amin-Hanjani S, Brown DC, Corey AS, Germano IM, Hadley JA, Jagadeesan BD, Jurgens JS, Kennedy TA, Mechtler LL, Patel ND, Zipfel GJ. ACR Appropriateness Criteria Headache.J Am Coll Radiol. 2014 Jul;11(7):657-67
  • Lo SS, Gore EM, Bradley JD, Buatti JM, Germano IM, Ghafoori AP, Henderson MA, Murad GJ, Patchell RA, Patel SH, Robbins JR, Robins HI, Vassil AD, Wippold FJ 2nd, Yunes MJ, Videtic GM. ACR Appropriateness Criteria® Pre-Irradiation Evaluation and Management of Brain Metastases. J Palliat Med. 2014 Jun 27.
  • Germano IM and Binello E. Stem cells and gliomas: past, present, and future. J Neuro-Oncology [in press, 2014].
  • Binello E, Emdad l, Mormone E, Germano IM. Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade glioma and anti-invasive effects on glioma stem cells. J Neurooncol, 117(2):225-34, 2014. PMID 24493576
  • Barthélemy EJ, Benjamin E, Jean-Pierre MY, Poitevien G, Ernst S, Osborn I, Germano IM. A prospective emergency department-based study of pattern and outcome of neurologic and neurosurgical diseases in Haiti. World Neurosurg. Oct 9. S1878-8750(13)01298-9, 2013 PIMD 24121294
  • Binello E, Qadeer ZA, Kothari H, Emdad L,Germano IM. Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization in Vitro. Journal of Cancer, 3:166-174, 2012. PMID 22514559
  • Binello E, Germano IM. Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol, 14:256-265, 2012. PMID 22166262
  • Emdad L, D’Souza, Qadeer ZA, Kothari HP, Germano IM. Efficient Differentiation of Human Embryonic and induced pluripotent Stem Cells into Functional Astrocytes. Stem Cells and Development, 21(3):404-4120, 2012. PMID 21631388
  • Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria: Follow-up and Retreatment of Brain Metastasis. Am J Clin Oncology, 35(3):302-306, 2012. PMID 22609733
  • Binello E and Germano IM. Targeting glioma stem cells: a novel framework for brain tumors. Cancer Sci, 102:1958-1966, 2011. PMID 21848914
  • Binello E, Green S, Germano IM. Radiosurgery for high-grade glioma. Surg Neurol Int, 3(S2) 118-126, 2012. PMID 22826815
  • Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria Follow-up and Retreatment of brain Metastasis. Am J Clin Oncology, 2012 Jun;35(3):302-306. PMID 22609733
  • Emdad L, Qadeer ZA, Bederson LB, Kothari HP, Uzzaman M, Germano IM. Is there a common upstream link for autophagic and apoptotic cell death in human high grade gliomas? Neuro-Oncology, 13(7)725-35, 2011. PMID 21727211
  • Germano IM, Emdad l, Qader Z, Binello E, Uzzaman M. Embryonic stem cell (ESC) –mediated transgene delivery induces growth suppression, apoptosis, radiosensitization, and overcomes temozolomide resistance in malignant gliomas. Cancer Gene Therapy 17(9):664 – 74, 2010. PMID 20523363.
  • Germano IM, Swiss V, Casaccia P. Primary brain Tumors, Neural stem cells, and brain tumor cancer cells: where is the link? Neuro–pharmacology 58(6):903-10, 2010 PMID 20045420
  • Suh JH, Videtic GMM, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell R, Robins HI, Rogers CL, Wolfson AH, wippold FJ, Gaspar LP. ACR appropriateness Criteria: Single brain metastasis. Curr Probl Cancer. 34(3):162-74, 2010 PMID 20541055
  • Germano IM and Binello E. Gene therapy as an adjuvant treatment of malignant gliomas: from bench to bedside. J Neuro-Oncology 93:79-87, 2009. PMID 19430884
  • Binello E, Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology? J Neuro-Oncol 94(1): 145-8, 2009. PMID 19199004
  • Uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology, 11:102-108 2009. PMID 18676359
  • Videtic GMM, Gaspar LE, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Suh JH, Wolfson AH, Wippold FJ. American College of Radiology appropriateness criteria on multiple brain metastases. J Rad Oncol Biol Physics 75:961-965, 2009. PMID 19857783
  • Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope? Cancer Biology and Therapy 7(9): 1341-7, 2008. PMID 1879364
  • Benzil D, Abosch A, Germano IM, Gilmer Holy, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor, R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 109: 367-375, 2008. PMID 18759565
  • Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 106: 646-651, 2007. PMID 17432717
  • Germano IM, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 105:88-95, 2006. PMID 16871882
  • Uzzaman M, Benveniste R, Keller G,Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 19(3) E6, 2005. PMID 16190605
  • Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 103:115-123,2005. PMID 16121982
  • Benveniste R. and Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 63:542-549, 2005. PMID 15936381
  • Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 24: 980-91, 2005. PMID 15592527
  • Germano IM,Gracies JM, Weisz DJ,Tse W,Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson's disease- a double blind 12-month evaluation study. J Neurosurgery 101:36-42, 2004. PMID 15255249

References

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  1. ^ a b c "Isabelle M Germano, MD". Mount Sinai. Retrieved 21 July 2016.
  2. ^ Aufses, Jr., Arthur H.; Niss, Barbara (2002). This House of Noble Deeds The Mount Sinai Hospital, 1852-2002. NYU Press. ISBN 9780814705001.
  3. ^ Bahie Izzat, Tiront Young, Alex Schupper, Isabelle Germano (July 2024). "Molecular profile and clinical outcome of adult primary spinal cord glioblastoma". Journal of Neurosurgery: Spine. 41 (1) – via Research Gate - Journal of neurosurgery.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ "Progress of Women in Neurosurgery" (PDF). WFNS. Archived from the original (PDF) on 2016-08-16. Retrieved 21 July 2016.
  5. ^ Smith, Christopher. "Best Doctors 2000: Hall of Fame". New York Magazine. Retrieved 21 July 2016.
  6. ^ "Tumor Section Award and Lectureship Winners | Houston, Texas USA |". www.tumorsection.org. Retrieved 2024-10-16.
  7. ^ "LINAC and gamma knife radiosurgery | WorldCat.org". search.worldcat.org. Retrieved 2024-10-16.
  8. ^ "Web based pathology assessment in RTOG 98-04" (PDF). Woodward WA. 2014.
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