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{{Short description|Protein in humans}}
==C13orf16==
{{infobox gene}}


'''Chromosome 13 open reading frame 16''' is a [[protein]] in [[homo sapiens]] encoded by the ''C13orf16'' [[gene]]. There is one alias name, '''TEX29''', for the high testis expression of this gene due to [[spermatogenesis]].<ref name=":0">{{Cite web |title=Home - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref><ref name=":1">{{Cite web |title=GeneCards |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=TEX29 |access-date=December 13, 2024 |website=GeneCards}}</ref>
<nowiki>{{Infobox_gene}}</nowiki>
===Table of Contents===
==> Gene==
Chromosome 13 open reading frame 16 is a [[protein]] in [[homo sapiens|''Homo sapiens'']], encoded by the ''C13orf16'' [[gene]]. There is one alias name, TEX29, for the high testis expression of this gene due to [[spermatogenesis]].* (ncbi gene) (genecards)


C13orf16 in Homo sapiens is located on the long arm of chromosome 13 at q34.<ref name=":1" /> The spliced gene is 859 [[Nucleotide|nucleotides]], has 7 [[exons]] and is located on the plus strand.<ref name=":0" />
'''<u>Gene Location</u>'''


C13orf16 is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the [[hippocampus]] and [[cerebellum]].<ref name=":0" /><ref>{{Cite web |title=AceView: Gene:C13orf16, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. |url=https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=c13orf16&submit=Go |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref>
''C13orf16'' in ''Homo sapiens'' is located on the long arm of chromosome 13 at q34.* (genecards) The spliced gene is 859 [[Nucleotide|nucleotides]], has 7 [[exons]], and is located on the plus strand.* (ncbi gene)


== Protein ==
'''<u>Gene Regulation</u>'''
The human C13orf16 protein encoded by the [[mRNA]] sequence is 174 amino acids in length.<ref name=":2">{{Cite web |title=Home - Protein - NCBI |url=https://www.ncbi.nlm.nih.gov/protein/ |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref> The molecular weight without post-transitional modifications is 18.4 KD<ref name=":3">{{Cite web |title=SAPS |url=https://www.ebi.ac.uk/jdispatcher/seqstats/saps |access-date=2024-12-14 |website=www.ebi.ac.uk}}</ref> and the basal [[isoelectric point]] value is 4.99 pH.<ref>{{Cite web |title=PhosphoSitePlus |url=https://www.phosphosite.org/homeAction.action |access-date=2024-12-14 |website=www.phosphosite.org}}</ref>


Human C13orf16 is localized both intracellularly, in the [[Cell nucleus|nucleus]], and extracellularly with one [[transmembrane domain]] from amino acids 80-102.<ref name=":2" /> There are no [[asparagine]]s, resulting in no [[N-glycosylation]] sites.<ref name=":3" />
''C13orf16'' is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the [[hippocampus]] and [[cerebellum]]. (ncbi gene) (aceview)


There are five interacting proteins for human C13orf16, all identified by physical interactions.<ref name=":1" /><ref name=":4">{{Cite web |title=GeneMANIA |url=https://genemania.org/search/homo-sapiens/c13orf16/ |access-date=2024-12-14 |website=genemania.org}}</ref><ref name=":5">{{Cite web |title=TEX29 Result Summary {{!}} BioGRID |url=https://thebiogrid.org/125748/summary/homo-sapiens/tex29.html |access-date=2024-12-14 |website=thebiogrid.org}}</ref>
==> Protein==
The Human ''C13orf16'' protein encoded by the [[mRNA]] sequence is 174 amino acids in length<ref>[2]</ref>. The molecular weight without post-transitional modifications is 18.4 KD* (saps) and the basal [[isoelectric point]] value is 4.99 pH.* (phosphositeplus)


'''<u>Protein Regulation</u>'''

Human ''C13orf16'' is localized both intracellularly, in the [[nucleus]], and extracellularly with one [[transmembrane domain]] from amino acids 80-102. (ncbi protein) There are no [[Asparagine|asparagines]], resulting in no [[N-glycosylation]] sites.* (compositional analysis)

<u>'''Interacting Proteins'''</u>

There are five interacting proteins for Human ''C13orf16'', all identified by physical interactions. (genecards) (other two)
{| class="wikitable"
{| class="wikitable"
|+ Interacting proteins for human C13orf16 protein<ref name=":1" /><ref name=":4" /><ref name=":5" />
|'''Abbreviated Name'''
|-
|'''Full Name'''
! Abbreviated Name
|'''Brief Description'''
! Full Name
! Brief Description
|-
|-
|PTS
|PTS
Line 51: Line 44:
|Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport
|Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport
|}
|}
Table 1: Interacting proteins for Human ''C13orf16'' protein. (same citations)


==> Homology/Evolution==
== Homology and evolution==
The C13orf16 protein was only found to have [[orthologs]] in [[Placentalia|placental mammals]] and most distantly found in the [[Proboscidea]] [[taxonomic group]]. (ncbi blast)
The C13orf16 protein was only found to have [[orthologs]] in [[Placentalia|placental mammals]] and most distantly found in the [[Proboscidea]] [[taxonomic group]].<ref name=":6">{{Cite web |title=Protein BLAST: search protein databases using a protein query |url=https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins |access-date=2024-12-14 |website=blast.ncbi.nlm.nih.gov}}</ref>
In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human ''C13orf16'' protein. (timetree) Color coordinated by species taxonomic group. (ncbi blast)[[File:Mammalian Orthologs of Human Protein C13orf16.png|thumb|Orthologs of Human ''C13orf16'' protein.]]
In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human C13orf16 protein.<ref>{{Cite web |title=TimeTree :: The Timescale of Life |url=https://timetree.org/ |access-date=2024-12-14 |website=timetree.org |language=en}}</ref>
{| class="wikitable"
|+ Orthologs of human C13orf16 protein
|-
|Genus & Species
|Common Name
|Taxonomic Group
|Date of Divergence (MYA)
|Accession Number<ref name=":2" />
|Sequence Length (aa)
|Sequence Identity to Human Protein
|Sequence Similarity to Human Protein
|-
|''Homo sapiens''
|[[Human]]
|[[Primate|Primates]]
|0
|NP_001290062
|174
|100%
|100%
|-
|''Nomascus leucogenys''
|[[Gibbon|Northern Gibbon]]
|[[Primate|Primates]]
|19.5
|XP_012362426
|173
|91%
|94.80%
|-
|''Macaca mulatta''
|[[Rhesus macaque|Rhesus Macaque]]
|[[Primate|Primates]]
|28.8
|XP_028693172
|182
|44.30%
|51.70%
|-
|''Cebus imitator''
|[[White-faced capuchin|White-faced Capuchin]]
|[[Primate|Primates]]
|43
|XP_037585341
|179
|70.60%
|77.80%
|-
|''Peromyscus maniculatus bairdii''
|[[Deer Mouse]]
|[[Rodent|Rodentia]]
|87
|XP_042118685
|176
|27.20%
|38.60%
|-
|''Peromyscus leucopus''
|[[White-footed mouse|White-Footed Mouse]]
|[[Rodent|Rodentia]]
|87
|XP_037067483
|176
|26.70%
|38.60%
|-
|''Oryctolagus cuniculus''
|[[European rabbit|European Rabbit]]
|[[Lagomorpha]]
|87
|XP_051685630
|143
|25.80%
|30.80%
|-
|''Phoca vitulina''
|[[Harbor seal|Harbor Seal]]
|[[Carnivora]]
|94
|XP_032258415
|162
|34%
|43.50%
|-
|''Neofelis nebulosa''
|[[Clouded leopard|Clouded Leopard]]
|[[Carnivora]]
|94
|XP_058598545
|165
|34.00%
|45.20%
|-
|''Phacochoerus africanus''
|[[Warthog]]
|[[Artiodactyl|Artiodactyla]]
|94
|XP_047612273
|171
|32.10%
|41.80%
|-
|''Balaenoptera ricei''
|[[Rice's whale|Rice's Whale]]
|[[Artiodactyl|Artiodactyla]]
|94
|XP_059759229
|147
|29.30%
|36.40%
|-
|''Hyaena hyaena''
|[[Striped hyena|Striped Hyena]]
|[[Carnivora]]
|94
|XP_039082615
|151
|29.00%
|39.40%
|-
|''Ailuropoda melanoleuca''
|[[Giant panda|Giant Panda]]
|[[Carnivora]]
|94
|XP_034521380
|147
|25%
|31.20%
|-
|''Hippopotamus amphibius kiboko''
|[[Hippopotamus|East African Hippo]]
|[[Artiodactyl|Artiodactyla]]
|94
|XP_057563793
|147
|23.70%
|34.30%
|-
|''Artibeus jamaicensis''
|[[Jamaican fruit bat|Jamacian Fruit Bat]]
|[[Chiroptera]]
|94
|XP_036993559.2
|149
|21.70%
|30.40%
|-
|''Vulpes lagopus''
|[[Arctic fox|Arctic Fox]]
|[[Carnivora]]
|94
|XP_041586767
|178
|21.7%%
|30.0%%
|-
|''Equus caballus''
|[[Horse]]
|[[Perissodactyla]]
|94
|XP_005601398
|136
|20.80%
|27.00%
|-
|''Talpa occidentalis''
|[[Spanish mole|Spanish Mole]]
|[[Talpidae]]
|94
|XP_037383406
|162
|19.30%
|25.00%
|-
|''Diceros bicornis minor''
|[[Black rhinoceros|Black Rhino]]
|[[Perissodactyla]]
|94
|XP_058403718
|181
|18.80%
|24%
|-
|''Elephas maximus indicus''
|[[Indian elephant|Indian Elephant]]
|[[Proboscidea]]
|99
|XP_049723476
|145
|23.80%
|35.10%
|}

== References ==
{{reflist}}




[[Category:Genes on human chromosome 13]]
==> References==
[[Category:Human proteins]]
<ref>https://www.ncbi.nlm.nih.gov/protein/NP_001069929.1</ref>
<ref>https://www.ncbi.nlm.nih.gov/protein/NP_001069929.1?report=fasta</ref>
https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins

Latest revision as of 09:45, 19 December 2024

TEX29
Identifiers
AliasesTEX29, C13orf16, bA474D23.1, testis expressed 29
External IDsHomoloGene: 51840; GeneCards: TEX29; OMA:TEX29 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

121793

n/a

Ensembl

ENSG00000153495

n/a

UniProt

Q8N6K0

n/a

RefSeq (mRNA)

NM_152324
NM_001303133

n/a

RefSeq (protein)

NP_001290062
NP_689537

n/a

Location (UCSC)Chr 13: 111.32 – 111.34 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Chromosome 13 open reading frame 16 is a protein in homo sapiens encoded by the C13orf16 gene. There is one alias name, TEX29, for the high testis expression of this gene due to spermatogenesis.[3][4]

C13orf16 in Homo sapiens is located on the long arm of chromosome 13 at q34.[4] The spliced gene is 859 nucleotides, has 7 exons and is located on the plus strand.[3]

C13orf16 is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the hippocampus and cerebellum.[3][5]

Protein

[edit]

The human C13orf16 protein encoded by the mRNA sequence is 174 amino acids in length.[6] The molecular weight without post-transitional modifications is 18.4 KD[7] and the basal isoelectric point value is 4.99 pH.[8]

Human C13orf16 is localized both intracellularly, in the nucleus, and extracellularly with one transmembrane domain from amino acids 80-102.[6] There are no asparagines, resulting in no N-glycosylation sites.[7]

There are five interacting proteins for human C13orf16, all identified by physical interactions.[4][9][10]

Interacting proteins for human C13orf16 protein[4][9][10]
Abbreviated Name Full Name Brief Description
PTS 6-Pyruvoyltetrahydropterin Synthase Elimination of inorganic triphosphate from dihydroneopterin triphosphate

(2nd and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP)

SLC16A2 Solute Carrier Family 16 Member 2 Non-redundant, thyroid hormone transporter
STEAP3 STEAP Family Member 3, Metalloreductase Iron transporter, can reduce both iron (Fe3+) and copper (Cu2+) cations
SLC4A7 Solute Carrier Family 4  Member 7 Sodium bicarbonate cotransporter, transports sodium and bicarbonate ions in a 1:1 ratio, considered an electroneutral cotransporter
SLC6A15 Solute Carrier Family 6 Member 15 Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport

Homology and evolution

[edit]

The C13orf16 protein was only found to have orthologs in placental mammals and most distantly found in the Proboscidea taxonomic group.[11] In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human C13orf16 protein.[12]

Orthologs of human C13orf16 protein
Genus & Species Common Name Taxonomic Group Date of Divergence (MYA) Accession Number[6] Sequence Length (aa) Sequence Identity to Human Protein Sequence Similarity to Human Protein
Homo sapiens Human Primates 0 NP_001290062 174 100% 100%
Nomascus leucogenys Northern Gibbon Primates 19.5 XP_012362426 173 91% 94.80%
Macaca mulatta Rhesus Macaque Primates 28.8 XP_028693172 182 44.30% 51.70%
Cebus imitator White-faced Capuchin Primates 43 XP_037585341 179 70.60% 77.80%
Peromyscus maniculatus bairdii Deer Mouse Rodentia 87 XP_042118685 176 27.20% 38.60%
Peromyscus leucopus White-Footed Mouse Rodentia 87 XP_037067483 176 26.70% 38.60%
Oryctolagus cuniculus European Rabbit Lagomorpha 87 XP_051685630 143 25.80% 30.80%
Phoca vitulina Harbor Seal Carnivora 94 XP_032258415 162 34% 43.50%
Neofelis nebulosa Clouded Leopard Carnivora 94 XP_058598545 165 34.00% 45.20%
Phacochoerus africanus Warthog Artiodactyla 94 XP_047612273 171 32.10% 41.80%
Balaenoptera ricei Rice's Whale Artiodactyla 94 XP_059759229 147 29.30% 36.40%
Hyaena hyaena Striped Hyena Carnivora 94 XP_039082615 151 29.00% 39.40%
Ailuropoda melanoleuca Giant Panda Carnivora 94 XP_034521380 147 25% 31.20%
Hippopotamus amphibius kiboko East African Hippo Artiodactyla 94 XP_057563793 147 23.70% 34.30%
Artibeus jamaicensis Jamacian Fruit Bat Chiroptera 94 XP_036993559.2 149 21.70% 30.40%
Vulpes lagopus Arctic Fox Carnivora 94 XP_041586767 178 21.7%% 30.0%%
Equus caballus Horse Perissodactyla 94 XP_005601398 136 20.80% 27.00%
Talpa occidentalis Spanish Mole Talpidae 94 XP_037383406 162 19.30% 25.00%
Diceros bicornis minor Black Rhino Perissodactyla 94 XP_058403718 181 18.80% 24%
Elephas maximus indicus Indian Elephant Proboscidea 99 XP_049723476 145 23.80% 35.10%

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153495 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b c "Home - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  4. ^ a b c d "GeneCards". GeneCards. Retrieved December 13, 2024.
  5. ^ "AceView: Gene:C13orf16, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  6. ^ a b c "Home - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  7. ^ a b "SAPS". www.ebi.ac.uk. Retrieved 2024-12-14.
  8. ^ "PhosphoSitePlus". www.phosphosite.org. Retrieved 2024-12-14.
  9. ^ a b "GeneMANIA". genemania.org. Retrieved 2024-12-14.
  10. ^ a b "TEX29 Result Summary | BioGRID". thebiogrid.org. Retrieved 2024-12-14.
  11. ^ "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  12. ^ "TimeTree :: The Timescale of Life". timetree.org. Retrieved 2024-12-14.
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