C13orf16: Difference between revisions
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{{Short description|Protein in humans}} |
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==C13orf16== |
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{{infobox gene}} |
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'''Chromosome 13 open reading frame 16''' is a [[protein]] in [[homo sapiens]] encoded by the ''C13orf16'' [[gene]]. There is one alias name, '''TEX29''', for the high testis expression of this gene due to [[spermatogenesis]].<ref name=":0">{{Cite web |title=Home - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref><ref name=":1">{{Cite web |title=GeneCards |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=TEX29 |access-date=December 13, 2024 |website=GeneCards}}</ref> |
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<nowiki>{{Infobox_gene}}</nowiki> |
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===Table of Contents=== |
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==> Gene== |
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Chromosome 13 open reading frame 16 is a [[protein]] in [[homo sapiens|''Homo sapiens'']], encoded by the ''C13orf16'' [[gene]]. There is one alias name, TEX29, for the high testis expression of this gene due to [[spermatogenesis]].<ref name=":0">{{Cite web |title=Home - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref><ref name=":1">{{Cite web |title=GeneCards |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=TEX29 |access-date=December 13, 2024 |website=GeneCards}}</ref> |
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C13orf16 in Homo sapiens is located on the long arm of chromosome 13 at q34.<ref name=":1" /> The spliced gene is 859 [[Nucleotide|nucleotides]], has 7 [[exons]] and is located on the plus strand.<ref name=":0" /> |
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'''<u>Gene Location</u>''' |
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C13orf16 is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the [[hippocampus]] and [[cerebellum]].<ref name=":0" /><ref>{{Cite web |title=AceView: Gene:C13orf16, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. |url=https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=c13orf16&submit=Go |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref> |
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''C13orf16'' in ''Homo sapiens'' is located on the long arm of chromosome 13 at q34.<ref name=":1" /> The spliced gene is 859 [[Nucleotide|nucleotides]], has 7 [[exons]], and is located on the plus strand.<ref name=":0" /> |
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== Protein == |
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'''<u>Gene Regulation</u>''' |
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The human C13orf16 protein encoded by the [[mRNA]] sequence is 174 amino acids in length.<ref name=":2">{{Cite web |title=Home - Protein - NCBI |url=https://www.ncbi.nlm.nih.gov/protein/ |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref> The molecular weight without post-transitional modifications is 18.4 KD<ref name=":3">{{Cite web |title=SAPS |url=https://www.ebi.ac.uk/jdispatcher/seqstats/saps |access-date=2024-12-14 |website=www.ebi.ac.uk}}</ref> and the basal [[isoelectric point]] value is 4.99 pH.<ref>{{Cite web |title=PhosphoSitePlus |url=https://www.phosphosite.org/homeAction.action |access-date=2024-12-14 |website=www.phosphosite.org}}</ref> |
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Human C13orf16 is localized both intracellularly, in the [[Cell nucleus|nucleus]], and extracellularly with one [[transmembrane domain]] from amino acids 80-102.<ref name=":2" /> There are no [[asparagine]]s, resulting in no [[N-glycosylation]] sites.<ref name=":3" /> |
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''C13orf16'' is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the [[hippocampus]] and [[cerebellum]].<ref name=":0" /><ref>{{Cite web |title=AceView: Gene:C13orf16, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. |url=https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=c13orf16&submit=Go |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref> |
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There are five interacting proteins for human C13orf16, all identified by physical interactions.<ref name=":1" /><ref name=":4">{{Cite web |title=GeneMANIA |url=https://genemania.org/search/homo-sapiens/c13orf16/ |access-date=2024-12-14 |website=genemania.org}}</ref><ref name=":5">{{Cite web |title=TEX29 Result Summary {{!}} BioGRID |url=https://thebiogrid.org/125748/summary/homo-sapiens/tex29.html |access-date=2024-12-14 |website=thebiogrid.org}}</ref> |
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==> Protein== |
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The Human ''C13orf16'' protein encoded by the [[mRNA]] sequence is 174 amino acids in length.<ref name=":2">{{Cite web |title=Home - Protein - NCBI |url=https://www.ncbi.nlm.nih.gov/protein/ |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref> The molecular weight without post-transitional modifications is 18.4 KD<ref name=":3">{{Cite web |title=SAPS |url=https://www.ebi.ac.uk/jdispatcher/seqstats/saps |access-date=2024-12-14 |website=www.ebi.ac.uk}}</ref> and the basal [[isoelectric point]] value is 4.99 pH.<ref>{{Cite web |title=PhosphoSitePlus |url=https://www.phosphosite.org/homeAction.action |access-date=2024-12-14 |website=www.phosphosite.org}}</ref> |
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'''<u>Protein Regulation</u>''' |
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Human ''C13orf16'' is localized both intracellularly, in the [[nucleus]], and extracellularly with one [[transmembrane domain]] from amino acids 80-102.<ref name=":2" /> There are no [[Asparagine|asparagines]], resulting in no [[N-glycosylation]] sites.<ref name=":3" /> |
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<u>'''Interacting Proteins'''</u> |
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There are five interacting proteins for Human ''C13orf16'', all identified by physical interactions.<ref name=":1" /><ref name=":4">{{Cite web |title=GeneMANIA |url=https://genemania.org/search/homo-sapiens/c13orf16/ |access-date=2024-12-14 |website=genemania.org}}</ref><ref name=":5">{{Cite web |title=TEX29 Result Summary {{!}} BioGRID |url=https://thebiogrid.org/125748/summary/homo-sapiens/tex29.html |access-date=2024-12-14 |website=thebiogrid.org}}</ref> |
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{| class="wikitable" |
{| class="wikitable" |
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|+ Interacting proteins for human C13orf16 protein<ref name=":1" /><ref name=":4" /><ref name=":5" /> |
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|'''Abbreviated Name''' |
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|- |
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|'''Full Name''' |
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! Abbreviated Name |
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|'''Brief Description''' |
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! Full Name |
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! Brief Description |
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|- |
|- |
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|PTS |
|PTS |
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|Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport |
|Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport |
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Table 1: Interacting proteins for Human ''C13orf16'' protein.<ref name=":1" /><ref name=":4" /><ref name=":5" /> |
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== Homology and evolution== |
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The C13orf16 protein was only found to have [[orthologs]] in [[Placentalia|placental mammals]] and most distantly found in the [[Proboscidea]] [[taxonomic group]].<ref name=":6">{{Cite web |title=Protein BLAST: search protein databases using a protein query |url=https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins |access-date=2024-12-14 |website=blast.ncbi.nlm.nih.gov}}</ref> |
The C13orf16 protein was only found to have [[orthologs]] in [[Placentalia|placental mammals]] and most distantly found in the [[Proboscidea]] [[taxonomic group]].<ref name=":6">{{Cite web |title=Protein BLAST: search protein databases using a protein query |url=https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins |access-date=2024-12-14 |website=blast.ncbi.nlm.nih.gov}}</ref> |
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In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human |
In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human C13orf16 protein.<ref>{{Cite web |title=TimeTree :: The Timescale of Life |url=https://timetree.org/ |access-date=2024-12-14 |website=timetree.org |language=en}}</ref> |
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{| class="wikitable" |
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|+ Orthologs of human C13orf16 protein |
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|- |
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|Genus & Species |
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|Common Name |
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|Taxonomic Group |
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|Date of Divergence (MYA) |
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|Accession Number<ref name=":2" /> |
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|Sequence Length (aa) |
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|Sequence Identity to Human Protein |
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|Sequence Similarity to Human Protein |
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|- |
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|''Homo sapiens'' |
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|[[Human]] |
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|[[Primate|Primates]] |
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|0 |
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|NP_001290062 |
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|174 |
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|100% |
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|100% |
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|- |
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|''Nomascus leucogenys'' |
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|[[Gibbon|Northern Gibbon]] |
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|[[Primate|Primates]] |
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|19.5 |
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|XP_012362426 |
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|173 |
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|91% |
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|94.80% |
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|- |
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|''Macaca mulatta'' |
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|[[Rhesus macaque|Rhesus Macaque]] |
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|[[Primate|Primates]] |
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|28.8 |
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|XP_028693172 |
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|182 |
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|44.30% |
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|51.70% |
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|- |
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|''Cebus imitator'' |
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|[[White-faced capuchin|White-faced Capuchin]] |
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|[[Primate|Primates]] |
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|43 |
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|XP_037585341 |
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|179 |
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|70.60% |
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|77.80% |
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|- |
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|''Peromyscus maniculatus bairdii'' |
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|[[Deer Mouse]] |
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|[[Rodent|Rodentia]] |
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|87 |
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|XP_042118685 |
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|176 |
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|27.20% |
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|38.60% |
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|- |
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|''Peromyscus leucopus'' |
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|[[White-footed mouse|White-Footed Mouse]] |
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|[[Rodent|Rodentia]] |
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|87 |
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|XP_037067483 |
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|176 |
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|26.70% |
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|38.60% |
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|- |
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|''Oryctolagus cuniculus'' |
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|[[European rabbit|European Rabbit]] |
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|[[Lagomorpha]] |
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|87 |
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|XP_051685630 |
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|143 |
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|25.80% |
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|30.80% |
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|- |
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|''Phoca vitulina'' |
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|[[Harbor seal|Harbor Seal]] |
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|[[Carnivora]] |
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|94 |
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|XP_032258415 |
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|162 |
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|34% |
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|43.50% |
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|- |
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|''Neofelis nebulosa'' |
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|[[Clouded leopard|Clouded Leopard]] |
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|[[Carnivora]] |
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|94 |
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|XP_058598545 |
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|165 |
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|34.00% |
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|45.20% |
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|- |
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|''Phacochoerus africanus'' |
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|[[Warthog]] |
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|[[Artiodactyl|Artiodactyla]] |
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|94 |
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|XP_047612273 |
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|171 |
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|32.10% |
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|41.80% |
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|- |
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|''Balaenoptera ricei'' |
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|[[Rice's whale|Rice's Whale]] |
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|[[Artiodactyl|Artiodactyla]] |
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|94 |
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|XP_059759229 |
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|147 |
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|29.30% |
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|36.40% |
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|- |
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|''Hyaena hyaena'' |
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|[[Striped hyena|Striped Hyena]] |
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|[[Carnivora]] |
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|94 |
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|XP_039082615 |
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|151 |
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|29.00% |
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|39.40% |
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|- |
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|''Ailuropoda melanoleuca'' |
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|[[Giant panda|Giant Panda]] |
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|[[Carnivora]] |
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|94 |
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|XP_034521380 |
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|147 |
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|25% |
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|31.20% |
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|- |
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|''Hippopotamus amphibius kiboko'' |
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|[[Hippopotamus|East African Hippo]] |
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|[[Artiodactyl|Artiodactyla]] |
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|94 |
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|XP_057563793 |
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|147 |
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|23.70% |
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|34.30% |
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|- |
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|''Artibeus jamaicensis'' |
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|[[Jamaican fruit bat|Jamacian Fruit Bat]] |
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|[[Chiroptera]] |
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|94 |
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|XP_036993559.2 |
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|149 |
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|21.70% |
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|30.40% |
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|- |
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|''Vulpes lagopus'' |
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|[[Arctic fox|Arctic Fox]] |
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|[[Carnivora]] |
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|94 |
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|XP_041586767 |
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|178 |
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|21.7%% |
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|30.0%% |
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|- |
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|''Equus caballus'' |
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|[[Horse]] |
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|[[Perissodactyla]] |
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|94 |
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|XP_005601398 |
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|136 |
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|20.80% |
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|27.00% |
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|- |
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|''Talpa occidentalis'' |
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|[[Spanish mole|Spanish Mole]] |
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|[[Talpidae]] |
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|94 |
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|XP_037383406 |
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|162 |
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|19.30% |
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|25.00% |
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|- |
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|''Diceros bicornis minor'' |
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|[[Black rhinoceros|Black Rhino]] |
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|[[Perissodactyla]] |
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|94 |
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|XP_058403718 |
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|181 |
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|18.80% |
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|24% |
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|- |
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|''Elephas maximus indicus'' |
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|[[Indian elephant|Indian Elephant]] |
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|[[Proboscidea]] |
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|99 |
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|XP_049723476 |
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|145 |
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|23.80% |
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|35.10% |
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|} |
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== References == |
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{{reflist}} |
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[[Category:Genes on human chromosome 13]] |
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==> References== |
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[[Category:Human proteins]] |
Latest revision as of 09:45, 19 December 2024
TEX29 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | TEX29, C13orf16, bA474D23.1, testis expressed 29 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | HomoloGene: 51840; GeneCards: TEX29; OMA:TEX29 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Chromosome 13 open reading frame 16 is a protein in homo sapiens encoded by the C13orf16 gene. There is one alias name, TEX29, for the high testis expression of this gene due to spermatogenesis.[3][4]
C13orf16 in Homo sapiens is located on the long arm of chromosome 13 at q34.[4] The spliced gene is 859 nucleotides, has 7 exons and is located on the plus strand.[3]
C13orf16 is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the hippocampus and cerebellum.[3][5]
Protein
[edit]The human C13orf16 protein encoded by the mRNA sequence is 174 amino acids in length.[6] The molecular weight without post-transitional modifications is 18.4 KD[7] and the basal isoelectric point value is 4.99 pH.[8]
Human C13orf16 is localized both intracellularly, in the nucleus, and extracellularly with one transmembrane domain from amino acids 80-102.[6] There are no asparagines, resulting in no N-glycosylation sites.[7]
There are five interacting proteins for human C13orf16, all identified by physical interactions.[4][9][10]
Abbreviated Name | Full Name | Brief Description |
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PTS | 6-Pyruvoyltetrahydropterin Synthase | Elimination of inorganic triphosphate from dihydroneopterin triphosphate
(2nd and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP) |
SLC16A2 | Solute Carrier Family 16 Member 2 | Non-redundant, thyroid hormone transporter |
STEAP3 | STEAP Family Member 3, Metalloreductase | Iron transporter, can reduce both iron (Fe3+) and copper (Cu2+) cations |
SLC4A7 | Solute Carrier Family 4 Member 7 | Sodium bicarbonate cotransporter, transports sodium and bicarbonate ions in a 1:1 ratio, considered an electroneutral cotransporter |
SLC6A15 | Solute Carrier Family 6 Member 15 | Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport |
Homology and evolution
[edit]The C13orf16 protein was only found to have orthologs in placental mammals and most distantly found in the Proboscidea taxonomic group.[11] In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human C13orf16 protein.[12]
Genus & Species | Common Name | Taxonomic Group | Date of Divergence (MYA) | Accession Number[6] | Sequence Length (aa) | Sequence Identity to Human Protein | Sequence Similarity to Human Protein |
Homo sapiens | Human | Primates | 0 | NP_001290062 | 174 | 100% | 100% |
Nomascus leucogenys | Northern Gibbon | Primates | 19.5 | XP_012362426 | 173 | 91% | 94.80% |
Macaca mulatta | Rhesus Macaque | Primates | 28.8 | XP_028693172 | 182 | 44.30% | 51.70% |
Cebus imitator | White-faced Capuchin | Primates | 43 | XP_037585341 | 179 | 70.60% | 77.80% |
Peromyscus maniculatus bairdii | Deer Mouse | Rodentia | 87 | XP_042118685 | 176 | 27.20% | 38.60% |
Peromyscus leucopus | White-Footed Mouse | Rodentia | 87 | XP_037067483 | 176 | 26.70% | 38.60% |
Oryctolagus cuniculus | European Rabbit | Lagomorpha | 87 | XP_051685630 | 143 | 25.80% | 30.80% |
Phoca vitulina | Harbor Seal | Carnivora | 94 | XP_032258415 | 162 | 34% | 43.50% |
Neofelis nebulosa | Clouded Leopard | Carnivora | 94 | XP_058598545 | 165 | 34.00% | 45.20% |
Phacochoerus africanus | Warthog | Artiodactyla | 94 | XP_047612273 | 171 | 32.10% | 41.80% |
Balaenoptera ricei | Rice's Whale | Artiodactyla | 94 | XP_059759229 | 147 | 29.30% | 36.40% |
Hyaena hyaena | Striped Hyena | Carnivora | 94 | XP_039082615 | 151 | 29.00% | 39.40% |
Ailuropoda melanoleuca | Giant Panda | Carnivora | 94 | XP_034521380 | 147 | 25% | 31.20% |
Hippopotamus amphibius kiboko | East African Hippo | Artiodactyla | 94 | XP_057563793 | 147 | 23.70% | 34.30% |
Artibeus jamaicensis | Jamacian Fruit Bat | Chiroptera | 94 | XP_036993559.2 | 149 | 21.70% | 30.40% |
Vulpes lagopus | Arctic Fox | Carnivora | 94 | XP_041586767 | 178 | 21.7%% | 30.0%% |
Equus caballus | Horse | Perissodactyla | 94 | XP_005601398 | 136 | 20.80% | 27.00% |
Talpa occidentalis | Spanish Mole | Talpidae | 94 | XP_037383406 | 162 | 19.30% | 25.00% |
Diceros bicornis minor | Black Rhino | Perissodactyla | 94 | XP_058403718 | 181 | 18.80% | 24% |
Elephas maximus indicus | Indian Elephant | Proboscidea | 99 | XP_049723476 | 145 | 23.80% | 35.10% |
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000153495 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Home - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
- ^ a b c d "GeneCards". GeneCards. Retrieved December 13, 2024.
- ^ "AceView: Gene:C13orf16, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
- ^ a b c "Home - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
- ^ a b "SAPS". www.ebi.ac.uk. Retrieved 2024-12-14.
- ^ "PhosphoSitePlus". www.phosphosite.org. Retrieved 2024-12-14.
- ^ a b "GeneMANIA". genemania.org. Retrieved 2024-12-14.
- ^ a b "TEX29 Result Summary | BioGRID". thebiogrid.org. Retrieved 2024-12-14.
- ^ "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
- ^ "TimeTree :: The Timescale of Life". timetree.org. Retrieved 2024-12-14.