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{{For|other people called Doug Turnbull|Douglas Turnbull (disambiguation)}}
{{Infobox person/Wikidata
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{{Infobox scientist
| name = Sir Doug Turnbull
| honorific_prefix = [[Sir]]
|birth_name = Douglass Matthew Turnbull
| birth_date =
| name = Douglass Turnbull
| honorific_suffix = {{post-nominals|country=GBR|FRS|FMedSci|size=100%}}
⚫
| module= {{Infobox scientist
| alma_mater = [[Newcastle University]]
| embed=yes
| workplaces = {{hlist|[[Wellcome Trust]] Centre for Mitochondrial Research |[[Newcastle University]]}}
⚫
| thesis_title = Mitochondrial cytopathies: clinical and experimental studies
| awards = {{hlist|[[Knight Bachelor]]|Jean Hunter Prize}}
⚫
| thesis_url = http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.475681
⚫
| thesis_title = Mitochondrial cytopathies: clinical and experimental studies
⚫
| thesis_year = 1983
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| thesis_url = http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.475681
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|field = {{Plainlist|
⚫
| thesis_year = 1983
⚫
|field = {{Plainlist|
* [[Mitochondrial donation]]
* [[Mitochondrial donation]]
* [[Mitochondrial disease]]s}}
* [[Mitochondrial disease]]s}}
| doctoral_advisor =
| doctoral_advisor =
| doctoral_student =
| doctoral_student =
| website = {{URL|http://www.newcastle-mitochondria.com/portfolio/professor-doug-turnbull}}
| website = {{URL|http://www.newcastle-mitochondria.com/portfolio/professor-doug-turnbull}}
}}
}}}}{{For|the lacrosse player|Doug Turnbull}}
Sir '''Douglass Matthew Turnbull''' [[FMedSci]] is [[Professor]] of [[Neurology]] at [[Newcastle University]], an Honorary Consultant Neurologist at [[Newcastle upon Tyne Hospitals NHS Foundation Trust]]<ref name=nhs>{{cite web|archiveurl=https://web.archive.org/web/20150625022435/http://www.newcastle-hospitals.org.uk/staff-profiles/12244.aspx|archivedate=2015-06-25|url=http://www.newcastle-hospitals.org.uk/staff-profiles/12244.aspx|website=newcastle-hospitals.org.uk|title=Turnbull, Professor Douglass M}}</ref> and a director of the [[Wellcome Trust]] Centre for [[Mitochondrion|Mitochondrial Research]].<Ref name=mito>{{cite web|url=http://www.newcastle-mitochondria.com/portfolio/professor-doug-turnbull/|title=Professor Doug Turnbull: Personal Biography|website=newcastle-mitochondria.com|location=[[Newcastle upon Tyne]]|archiveurl=https://web.archive.org/web/20160331051532/http://www.newcastle-mitochondria.com/portfolio/professor-doug-turnbull/|archivedate=2016-03-31}}</ref><ref name=CravenTuppen2010>{{cite journal|last1=Craven|first1=Lyndsey|last2=Tuppen|first2=Helen A.|last3=Greggains|first3=Gareth D.|last4=Harbottle|first4=Stephen J.|last5=Murphy|first5=Julie L.|last6=Cree|first6=Lynsey M.|last7=Murdoch|first7=Alison P.|last8=Chinnery|first8=Patrick F.|last9=Taylor|first9=Robert W.|last10=Lightowlers|first10=Robert N.|last11=Herbert|first11=Mary|last12=Turnbull|first12=Douglass M.|title=Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease|journal=Nature|volume=465|issue=7294|year=2010|pages=82–85|pmid=20393463|pmc=2875160|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875160/|doi=10.1038/nature08958}} {{open access}}</ref><ref>{{YouTube|id=Sr7Jnr9qn44|title=Healing broken batteries: The Wellcome Trust Centre for Mitochondrial Research}}, [[Wellcome Trust]], London</ref><ref>{{cite web|url=http://www.thejournal.co.uk/north-east-analysis/analysis-news/newcastle-university-medical-pioneer-doug-9164327|website=thejournal.co.uk|title=Newcastle University medical pioneer Doug Turnbull discusses his game-changing research|publisher=[[The Journal (newspaper)|The Journal]]|location=Newcastle|author=Graeme Whitfield|year=2015}}</ref>
'''Sir Douglass Matthew Turnbull''' is [[professor]] of [[neurology]] at [[Newcastle University]], an honorary consultant neurologist at [[Newcastle upon Tyne Hospitals NHS Foundation Trust]]<ref name=nhs>{{cite web|archiveurl=https://web.archive.org/web/20150625022435/http://www.newcastle-hospitals.org.uk/staff-profiles/12244.aspx|archivedate=2015-06-25|url=http://www.newcastle-hospitals.org.uk/staff-profiles/12244.aspx|website=newcastle-hospitals.org.uk|title=Turnbull, Professor Douglass M}}</ref> and a director of the [[Wellcome Trust]] Centre for [[Mitochondrion|Mitochondrial Research]].<ref name=mito>{{cite web|url=http://www.newcastle-mitochondria.com/portfolio/professor-doug-turnbull/|title=Professor Doug Turnbull: Personal Biography|website=newcastle-mitochondria.com|date=17 March 2016 |location=[[Newcastle upon Tyne]]|archiveurl=https://web.archive.org/web/20160331051532/http://www.newcastle-mitochondria.com/portfolio/professor-doug-turnbull/|archivedate=2016-03-31}}</ref><ref name=CravenTuppen2010>{{cite journal|last1=Craven|first1=Lyndsey|last2=Tuppen|first2=Helen A.|last3=Greggains|first3=Gareth D.|last4=Harbottle|first4=Stephen J.|last5=Murphy|first5=Julie L.|last6=Cree|first6=Lynsey M.|last7=Murdoch|first7=Alison P.|last8=Chinnery|first8=Patrick F.|last9=Taylor|first9=Robert W.|last10=Lightowlers|first10=Robert N.|last11=Herbert|first11=Mary|last12=Turnbull|first12=Douglass M.|title=Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease|journal=Nature|volume=465|issue=7294|year=2010|pages=82–85|pmid=20393463|pmc=2875160|doi=10.1038/nature08958|bibcode=2010Natur.465...82C}} {{open access}}</ref><ref>{{YouTube|id=Sr7Jnr9qn44|title=Healing broken batteries: The Wellcome Trust Centre for Mitochondrial Research}}, [[Wellcome Trust]], London</ref><ref>{{cite web|url=http://www.thejournal.co.uk/north-east-analysis/analysis-news/newcastle-university-medical-pioneer-doug-9164327|website=thejournal.co.uk|title=Newcastle University medical pioneer Doug Turnbull discusses his game-changing research|publisher=[[The Journal (Newcastle upon Tyne newspaper)|The Journal]]|location=Newcastle|author=Graeme Whitfield|year=2015|access-date=2016-06-16|archive-date=2020-08-18|archive-url=https://web.archive.org/web/20200818023218/http://www.thejournal.co.uk/north-east-analysis/analysis-news/newcastle-university-medical-pioneer-doug-9164327|url-status=dead}}</ref>


==Education==
==Education==
Turnbull was educated at [[Newcastle University]], where he was awarded a [[Bachelor of Medicine, Bachelor of Surgery]] and qualifying as a [[junior doctor]].{{when|date=June 2016}}<ref name=mito/> He was subsequently awarded a [[PhD]] for research investigating [[mitochondria|Mitochondrial]] cytopathies.<ref>{{cite thesis|degree=PhD|publisher=Newcastle upon Tyne University|title=Mitochondrial cytopathies: clinical and experimental studies|first= Douglass Matthew|last=Turnbull|date=1983|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.475681|oclc=11274373}}</ref>
Turnbull was educated at [[Newcastle University]], where he was awarded a [[Bachelor of Medicine, Bachelor of Surgery]] and qualifying as a [[junior doctor]].{{when|date=June 2016}}<ref name=mito/> He was subsequently awarded a [[PhD]] for research investigating [[mitochondria]]l cytopathies.<ref>{{cite thesis|degree=PhD|publisher=Newcastle upon Tyne University|title=Mitochondrial cytopathies: clinical and experimental studies|first= Douglass Matthew|last=Turnbull|date=1983|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.475681|oclc=11274373}}</ref>


==Research==
==Research==
Turnbull's research investigates techniques for improving the lives of patients with [[mitochondrial disease]].<ref name=LightowlersChinnery1997>{{cite journal|last1=Lightowlers|first1=Robert N.|last2=Chinnery|first2=Patrick F.|last3=Turnbull|first3=Douglass M.|last4=Howell|first4=Neil|title=Mammalian mitochondrial genetics: heredity, heteroplasmy and disease|journal=Trends in Genetics|volume=13|issue=11|year=1997|pages=450–455|doi=10.1016/S0168-9525(97)01266-3}}</ref> {{As of|2016}} he has supervised 35 successful PhD students to completion and is currently supervising 10 PhD students in progress.<ref name=mito/> His most highly cited research<ref>{{Scopus|id= 55762540300}}</ref> has been published in world leading [[peer review]]ed [[scientific journals]] such as ''[[Nature (journal)|Nature]]'',<ref name=CravenTuppen2010/> ''[[Nature Genetics]]'',<ref name="TurnbullAndrews1999">{{cite journal|last1=Turnbull|first1=Douglass M.|last2=Andrews|first2=Richard M.|last3=Kubacka|first3=Iwona|last4=Chinnery|first4=Patrick F.|last5=Lightowlers|first5=Robert N.|last6=Howell|first6=Neil|journal=Nature Genetics|volume=23|issue=2|year=1999|pages=147–147|title=Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA|doi=10.1038/13779|pmid=10508508}}</ref><ref name="BenderKrishnan2006">{{cite journal|last1=Bender|first1=Andreas|last2=Krishnan|first2=Kim J|last3=Morris|first3=Christopher M|last4=Taylor|first4=Geoffrey A|last5=Reeve|first5=Amy K|last6=Perry|first6=Robert H|last7=Jaros|first7=Evelyn|last8=Hersheson|first8=Joshua S|last9=Betts|first9=Joanne|last10=Klopstock|first10=Thomas|last11=Taylor|first11=Robert W|last12=Turnbull|first12=Douglass M|title=High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease|journal=Nature Genetics|volume=38|issue=5|year=2006|pages=515–517|doi=10.1038/ng1769}}</ref> ''[[Nature Reviews Genetics]],''<ref name=TaylorTurnbull2005>{{cite journal|last1=Taylor|first1=Robert W.|last2=Turnbull|first2=Doug M.|title=Mitochondrial DNA mutations in human disease|journal=Nature Reviews Genetics|volume=6|issue=5|year=2005|pages=389–402|doi=10.1038/nrg1606}}</ref> the ''[[American Journal of Human Genetics]],''<ref name="HerrnstadtElson2002">{{cite journal|last1=Herrnstadt|first1=Corinna|last2=Elson|first2=Joanna L.|last3=Fahy|first3=Eoin|last4=Preston|first4=Gwen|last5=Turnbull|first5=Douglass M.|last6=Anderson|first6=Christen|last7=Ghosh|first7=Soumitra S.|last8=Olefsky|first8=Jerrold M.|last9=Beal|first9=M. Flint|last10=Davis|first10=Robert E.|last11=Howell|first11=Neil|title=Reduced-Median-Network Analysis of Complete Mitochondrial DNA Coding-Region Sequences for the Major African, Asian, and European Haplogroups|journal=The American Journal of Human Genetics|volume=70|issue=5|year=2002|pages=1152–1171|doi=10.1086/339933}} {{open access}}</ref> and the ''[[Journal of Clinical Investigation]]''.<ref name="TaylorBarron2003">{{cite journal|last1=Taylor|first1=Robert W.|last2=Barron|first2=Martin J.|last3=Borthwick|first3=Gillian M.|last4=Gospel|first4=Amy|last5=Chinnery|first5=Patrick F.|last6=Samuels|first6=David C.|last7=Taylor|first7=Geoffrey A.|last8=Plusa|first8=Stefan M.|last9=Needham|first9=Stephanie J.|last10=Greaves|first10=Laura C.|last11=Kirkwood|first11=Thomas B.L.|last12=Turnbull|first12=Douglass M.|title=Mitochondrial DNA mutations in human colonic crypt stem cells|journal=Journal of Clinical Investigation|volume=112|issue=9|year=2003|pages=1351–1360|doi=10.1172/JCI19435}} {{open access}}</ref>
Turnbull's research investigates techniques for improving the lives of patients with [[mitochondrial disease]].<ref name=LightowlersChinnery1997>{{cite journal|last1=Lightowlers|first1=Robert N.|last2=Chinnery|first2=Patrick F.|last3=Turnbull|first3=Douglass M.|last4=Howell|first4=Neil|title=Mammalian mitochondrial genetics: heredity, heteroplasmy and disease|journal=Trends in Genetics|volume=13|issue=11|year=1997|pages=450–455|doi=10.1016/S0168-9525(97)01266-3|pmid=9385842}}</ref> {{As of|2016}} he has supervised 35 successful PhD students to completion and is currently supervising 10 PhD students in progress.<ref name=mito/> His most highly cited research<ref>{{Scopus|id= 55762540300}}</ref> has been published in world leading [[peer review]]ed [[scientific journals]] such as ''[[Nature (journal)|Nature]]'',<ref name=CravenTuppen2010/> ''[[Nature Genetics]]'',<ref name="TurnbullAndrews1999">{{cite journal|last1=Turnbull|first1=Douglass M.|last2=Andrews|first2=Richard M.|last3=Kubacka|first3=Iwona|last4=Chinnery|first4=Patrick F.|last5=Lightowlers|first5=Robert N.|last6=Howell|first6=Neil|journal=Nature Genetics|volume=23|issue=2|year=1999|pages=147|title=Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA|doi=10.1038/13779|pmid=10508508|doi-access=free}}</ref><ref name="BenderKrishnan2006">{{cite journal|last1=Bender|first1=Andreas|last2=Krishnan|first2=Kim J|last3=Morris|first3=Christopher M|last4=Taylor|first4=Geoffrey A|last5=Reeve|first5=Amy K|last6=Perry|first6=Robert H|last7=Jaros|first7=Evelyn|last8=Hersheson|first8=Joshua S|last9=Betts|first9=Joanne|last10=Klopstock|first10=Thomas|last11=Taylor|first11=Robert W|last12=Turnbull|first12=Douglass M|title=High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease|journal=Nature Genetics|volume=38|issue=5|year=2006|pages=515–517|doi=10.1038/ng1769|pmid=16604074|s2cid=13956928}}</ref> ''[[Nature Reviews Genetics]],''<ref name=TaylorTurnbull2005>{{cite journal|last1=Taylor|first1=Robert W.|last2=Turnbull|first2=Doug M.|title=Mitochondrial DNA mutations in human disease|journal=Nature Reviews Genetics|volume=6|issue=5|year=2005|pages=389–402|doi=10.1038/nrg1606|pmid=15861210|pmc=1762815}}</ref> the ''[[American Journal of Human Genetics]],''<ref name="HerrnstadtElson2002">{{cite journal|last1=Herrnstadt|first1=Corinna|last2=Elson|first2=Joanna L.|last3=Fahy|first3=Eoin|last4=Preston|first4=Gwen|last5=Turnbull|first5=Douglass M.|last6=Anderson|first6=Christen|last7=Ghosh|first7=Soumitra S.|last8=Olefsky|first8=Jerrold M.|last9=Beal|first9=M. Flint|last10=Davis|first10=Robert E.|last11=Howell|first11=Neil|title=Reduced-Median-Network Analysis of Complete Mitochondrial DNA Coding-Region Sequences for the Major African, Asian, and European Haplogroups|journal=The American Journal of Human Genetics|volume=70|issue=5|year=2002|pages=1152–1171|doi=10.1086/339933|pmid=11938495|pmc=447592}} {{open access}}</ref> and the ''[[Journal of Clinical Investigation]]''.<ref name="TaylorBarron2003">{{cite journal|last1=Taylor|first1=Robert W.|last2=Barron|first2=Martin J.|last3=Borthwick|first3=Gillian M.|last4=Gospel|first4=Amy|last5=Chinnery|first5=Patrick F.|last6=Samuels|first6=David C.|last7=Taylor|first7=Geoffrey A.|last8=Plusa|first8=Stefan M.|last9=Needham|first9=Stephanie J.|last10=Greaves|first10=Laura C.|last11=Kirkwood|first11=Thomas B.L.|last12=Turnbull|first12=Douglass M.|title=Mitochondrial DNA mutations in human colonic crypt stem cells|journal=Journal of Clinical Investigation|volume=112|issue=9|year=2003|pages=1351–1360|doi=10.1172/JCI19435|pmid=14597761|pmc=228466}} {{open access}}</ref>


His research has been funded by the [[Welcome Trust]], the [[Biotechnology and Biological Sciences Research Council|Biotechnology and Biological Sciences Research Council (BBSRC)]] and the [[Medical Research Council (United Kingdom)|Medical Research Council (MRC)]].<ref>{{cite web|url=http://gtr.rcuk.ac.uk/person/C727E2B0-A636-4F29-9D0B-6D423A91FE19|title=UK Government grants awarded to Doug Turnbull|publisher=[[Research Councils UK]]|website=rcuk.ac.uk|location=Swindon|archiveurl=https://web.archive.org/web/20160616071504/http://gtr.rcuk.ac.uk/person/C727E2B0-A636-4F29-9D0B-6D423A91FE19|archivedate=2016-06-16}}</ref>
His research has been funded by the [[Wellcome Trust]], the [[Biotechnology and Biological Sciences Research Council|Biotechnology and Biological Sciences Research Council (BBSRC)]] and the [[Medical Research Council (United Kingdom)|Medical Research Council (MRC)]].<ref>{{cite web|url=http://gtr.rcuk.ac.uk/person/C727E2B0-A636-4F29-9D0B-6D423A91FE19|title=UK Government grants awarded to Doug Turnbull|publisher=[[Research Councils UK]]|website=rcuk.ac.uk|location=Swindon|archiveurl=https://web.archive.org/web/20160616071504/http://gtr.rcuk.ac.uk/person/C727E2B0-A636-4F29-9D0B-6D423A91FE19|archivedate=2016-06-16}}</ref>


==Awards and honours==
==Awards and honours==
Turnbull delivered the [[Goulstonian Lecturer|Goulstonian Lectures]] in 1992 and was awarded the Jean Hunter Prize in 2003, both by the [[Royal College of Physicians]].<ref name=mito/> He was elected a [[Fellow of the Academy of Medical Sciences]] in 2004.<ref name=fmedsci>{{cite web|url=http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-douglass-turnbull/|title=Professor Doug Turnbull FMedSci|website=acmedsci.ac.uk|location=London|publisher=[[Academy of Medical Sciences, United Kingdom|Academy of Medical Sciences]]|archiveurl=https://web.archive.org/web/20160616071749/http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-douglass-turnbull/|archivedate=2016-06-16}}</ref>
Turnbull delivered the [[Goulstonian Lecturer|Goulstonian Lectures]] in 1992 and was awarded the Jean Hunter Prize in 2003, both by the [[Royal College of Physicians]].<ref name=mito/> He was elected a [[Fellow of the Academy of Medical Sciences]] in 2004.<ref name=fmedsci>{{cite web|url=http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-douglass-turnbull/|title=Professor Doug Turnbull FMedSci|website=acmedsci.ac.uk|location=London|publisher=[[Academy of Medical Sciences, United Kingdom|Academy of Medical Sciences]]|archiveurl=https://web.archive.org/web/20160616071749/http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-douglass-turnbull/|archivedate=2016-06-16}}</ref>


Turnbull was knighted in the [[2016 Birthday Honours]].<ref name=sir>{{London Gazette |issue= 61608 |date=2016-06-11 |startpage=B2 |supp=yes}}</ref> According to the BBC, his knighthood was awarded for "creating a groundbreaking [[In vitro fertilisation|IVF]] technique which prevents disabling [[genetic disorder]]s from being passed on to future generations".<ref name=bbc>{{cite web|url=http://www.bbc.co.uk/news/health-36499807|website=bbc.co.uk|publisher=[[BBC News]]|location=London|title=Birthday honours: Mitochondrial disease doctor recognised|author=Anon|year=2016}}</ref> This technique uses [[mitochondrial donation]], also known as "three-person babies".<ref>{{cite web|archiveurl=https://web.archive.org/web/20160205083223/https://www.theguardian.com/science/2015/feb/05/three-person-embryos-mitochondrial-donation-prof-dough-turnbull|archivedate=2016-02-05|url=https://www.theguardian.com/science/2015/feb/05/three-person-embryos-mitochondrial-donation-prof-dough-turnbull|publisher=[[The Guardian]]|website=guardian.com|location=London|author=Mark Henderson|year=2015|title=Three-person embryos: how the mitochondrial donation battle was won. Prof Doug Turnbull successfully communicated difficult and controversial research with scientific accuracy, but in simple terms}}</ref><ref>{{cite web|archiveurl=https://web.archive.org/web/20160302185210/http://www.bbc.co.uk/news/health-31044255|archivedate=2016-03-02|url=http://www.bbc.co.uk/news/health-31044255|website=bbc.co.uk|location=London|publisher=[[BBC News]]|title='Three-person babies - not three-parent babies'|author=James Gallagher|year=2015}}</ref>
Turnbull was knighted in the [[2016 Birthday Honours]].<ref name=sir>{{London Gazette |issue= 61608 |date=2016-06-11 |page=B2 |supp=y}}</ref> According to the BBC, his knighthood was awarded for "creating a groundbreaking [[In vitro fertilisation|IVF]] technique which prevents disabling [[genetic disorder]]s from being passed on to future generations".<ref name=bbc>{{cite web|url=https://www.bbc.co.uk/news/health-36499807|website=bbc.co.uk|publisher=[[BBC News]]|location=London|title=Birthday honours: Mitochondrial disease doctor recognised|author=Anon|year=2016}}</ref> This technique uses [[mitochondrial donation]], also known as "three-person babies".<ref>{{cite web|archiveurl=https://web.archive.org/web/20160205083223/https://www.theguardian.com/science/2015/feb/05/three-person-embryos-mitochondrial-donation-prof-dough-turnbull|archivedate=2016-02-05|url=https://www.theguardian.com/science/2015/feb/05/three-person-embryos-mitochondrial-donation-prof-dough-turnbull|work=[[The Guardian]]|location=London|author=Mark Henderson|year=2015|title=Three-person embryos: how the mitochondrial donation battle was won. Prof Doug Turnbull successfully communicated difficult and controversial research with scientific accuracy, but in simple terms}}</ref><ref>{{cite web|archiveurl=https://web.archive.org/web/20160302185210/http://www.bbc.co.uk/news/health-31044255|archivedate=2016-03-02|url=https://www.bbc.co.uk/news/health-31044255|website=bbc.co.uk|location=London|publisher=[[BBC News]]|title=Three-person babies - not three-parent babies|author=James Gallagher|year=2015}}</ref>


Turnbull was awarded the [[Buchanan Medal]] for outstanding contributions to biomedicine particularly in relation to mitochondrial disease, including the development of a method to prevent their transmission.<ref name="Buchanan">{{cite web|url=https://royalsociety.org/people/doug-turnbull-14132/|title=Buchanan Medallist 2020|publisher=Royal Society|access-date= 18 August 2020| archive-url = https://web.archive.org/web/20191023205213/https://royalsociety.org/people/doug-turnbull-14132/ | archive-date = 23 October 2019 }}</ref>
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{{DEFAULTSORT:Turnbull, Douglas Matthew}}
[[Category:British neurologists]]
[[Category:Living people]]
[[Category:Living people]]
[[Category:Fellows of the Academy of Medical Sciences]]
[[Category:Fellows of the Academy of Medical Sciences (United Kingdom)]]
[[Category:Knights Bachelor]]
[[Category:Knights Bachelor]]
[[Category:NIHR Senior Investigators]]
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[[Category:Year of birth missing (living people)]]

Latest revision as of 17:14, 20 December 2024

For other people called Doug Turnbull, see Douglas Turnbull (disambiguation).
Sir
Douglass Turnbull
FRS FMedSci
Alma materNewcastle University
Awards
Scientific career
Fields
Institutions
ThesisMitochondrial cytopathies: clinical and experimental studies (1983)
Websitewww.newcastle-mitochondria.com/portfolio/professor-doug-turnbull

Sir Douglass Matthew Turnbull is professor of neurology at Newcastle University, an honorary consultant neurologist at Newcastle upon Tyne Hospitals NHS Foundation Trust[1] and a director of the Wellcome Trust Centre for Mitochondrial Research.[2][3][4][5]

Education

[edit]

Turnbull was educated at Newcastle University, where he was awarded a Bachelor of Medicine, Bachelor of Surgery and qualifying as a junior doctor.[when?][2] He was subsequently awarded a PhD for research investigating mitochondrial cytopathies.[6]

Research

[edit]

Turnbull's research investigates techniques for improving the lives of patients with mitochondrial disease.[7] As of 2016 he has supervised 35 successful PhD students to completion and is currently supervising 10 PhD students in progress.[2] His most highly cited research[8] has been published in world leading peer reviewed scientific journals such as Nature,[3] Nature Genetics,[9][10] Nature Reviews Genetics,[11] the American Journal of Human Genetics,[12] and the Journal of Clinical Investigation.[13]

His research has been funded by the Wellcome Trust, the Biotechnology and Biological Sciences Research Council (BBSRC) and the Medical Research Council (MRC).[14]

Awards and honours

[edit]

Turnbull delivered the Goulstonian Lectures in 1992 and was awarded the Jean Hunter Prize in 2003, both by the Royal College of Physicians.[2] He was elected a Fellow of the Academy of Medical Sciences in 2004.[15]

Turnbull was knighted in the 2016 Birthday Honours.[16] According to the BBC, his knighthood was awarded for "creating a groundbreaking IVF technique which prevents disabling genetic disorders from being passed on to future generations".[17] This technique uses mitochondrial donation, also known as "three-person babies".[18][19]

Turnbull was awarded the Buchanan Medal for outstanding contributions to biomedicine particularly in relation to mitochondrial disease, including the development of a method to prevent their transmission.[20]

References

[edit]
  1. ^ "Turnbull, Professor Douglass M". newcastle-hospitals.org.uk. Archived from the original on 2015-06-25.
  2. ^ a b c d "Professor Doug Turnbull: Personal Biography". newcastle-mitochondria.com. Newcastle upon Tyne. 17 March 2016. Archived from the original on 2016-03-31.
  3. ^ a b Craven, Lyndsey; Tuppen, Helen A.; Greggains, Gareth D.; Harbottle, Stephen J.; Murphy, Julie L.; Cree, Lynsey M.; Murdoch, Alison P.; Chinnery, Patrick F.; Taylor, Robert W.; Lightowlers, Robert N.; Herbert, Mary; Turnbull, Douglass M. (2010). "Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease". Nature. 465 (7294): 82–85. Bibcode:2010Natur.465...82C. doi:10.1038/nature08958. PMC 2875160. PMID 20393463. Open access icon
  4. ^ Healing broken batteries: The Wellcome Trust Centre for Mitochondrial Research on YouTube, Wellcome Trust, London
  5. ^ Graeme Whitfield (2015). "Newcastle University medical pioneer Doug Turnbull discusses his game-changing research". thejournal.co.uk. Newcastle: The Journal. Archived from the original on 2020-08-18. Retrieved 2016-06-16.
  6. ^ Turnbull, Douglass Matthew (1983). Mitochondrial cytopathies: clinical and experimental studies (PhD thesis). Newcastle upon Tyne University. OCLC 11274373.
  7. ^ Lightowlers, Robert N.; Chinnery, Patrick F.; Turnbull, Douglass M.; Howell, Neil (1997). "Mammalian mitochondrial genetics: heredity, heteroplasmy and disease". Trends in Genetics. 13 (11): 450–455. doi:10.1016/S0168-9525(97)01266-3. PMID 9385842.
  8. ^ Douglass Turnbull's publications indexed by the Scopus bibliographic database. (subscription required)
  9. ^ Turnbull, Douglass M.; Andrews, Richard M.; Kubacka, Iwona; Chinnery, Patrick F.; Lightowlers, Robert N.; Howell, Neil (1999). "Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA". Nature Genetics. 23 (2): 147. doi:10.1038/13779. PMID 10508508.
  10. ^ Bender, Andreas; Krishnan, Kim J; Morris, Christopher M; Taylor, Geoffrey A; Reeve, Amy K; Perry, Robert H; Jaros, Evelyn; Hersheson, Joshua S; Betts, Joanne; Klopstock, Thomas; Taylor, Robert W; Turnbull, Douglass M (2006). "High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease". Nature Genetics. 38 (5): 515–517. doi:10.1038/ng1769. PMID 16604074. S2CID 13956928.
  11. ^ Taylor, Robert W.; Turnbull, Doug M. (2005). "Mitochondrial DNA mutations in human disease". Nature Reviews Genetics. 6 (5): 389–402. doi:10.1038/nrg1606. PMC 1762815. PMID 15861210.
  12. ^ Herrnstadt, Corinna; Elson, Joanna L.; Fahy, Eoin; Preston, Gwen; Turnbull, Douglass M.; Anderson, Christen; Ghosh, Soumitra S.; Olefsky, Jerrold M.; Beal, M. Flint; Davis, Robert E.; Howell, Neil (2002). "Reduced-Median-Network Analysis of Complete Mitochondrial DNA Coding-Region Sequences for the Major African, Asian, and European Haplogroups". The American Journal of Human Genetics. 70 (5): 1152–1171. doi:10.1086/339933. PMC 447592. PMID 11938495. Open access icon
  13. ^ Taylor, Robert W.; Barron, Martin J.; Borthwick, Gillian M.; Gospel, Amy; Chinnery, Patrick F.; Samuels, David C.; Taylor, Geoffrey A.; Plusa, Stefan M.; Needham, Stephanie J.; Greaves, Laura C.; Kirkwood, Thomas B.L.; Turnbull, Douglass M. (2003). "Mitochondrial DNA mutations in human colonic crypt stem cells". Journal of Clinical Investigation. 112 (9): 1351–1360. doi:10.1172/JCI19435. PMC 228466. PMID 14597761. Open access icon
  14. ^ "UK Government grants awarded to Doug Turnbull". rcuk.ac.uk. Swindon: Research Councils UK. Archived from the original on 2016-06-16.
  15. ^ "Professor Doug Turnbull FMedSci". acmedsci.ac.uk. London: Academy of Medical Sciences. Archived from the original on 2016-06-16.
  16. ^ "No. 61608". The London Gazette (Supplement). 2016-06-11. p. B2.
  17. ^ Anon (2016). "Birthday honours: Mitochondrial disease doctor recognised". bbc.co.uk. London: BBC News.
  18. ^ Mark Henderson (2015). "Three-person embryos: how the mitochondrial donation battle was won. Prof Doug Turnbull successfully communicated difficult and controversial research with scientific accuracy, but in simple terms". The Guardian. London. Archived from the original on 2016-02-05.
  19. ^ James Gallagher (2015). "Three-person babies - not three-parent babies". bbc.co.uk. London: BBC News. Archived from the original on 2016-03-02.
  20. ^ "Buchanan Medallist 2020". Royal Society. Archived from the original on 23 October 2019. Retrieved 18 August 2020.
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