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{{short description|Indian biochemist, molecular biologist (born 1960)}}
{{short description|Indian biochemist, molecular biologist (born 1960)}}
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'''Jayant Bhalchandra Udgaonkar''' is a [[Molecular biology|molecular biologist]] studying the processes by which a [[Protein primary structure|random chain]] of [[Amino acid|amino acids]] stabilises into a functional [[Protein structure|structure]] during or after [[Translation (biology)|translation]].<ref>{{Cite web |title=Jayant B. Udgaonkar - IISER Pune |url=https://www.iiserpune.ac.in/research/department/biology/people/faculty/regular-faculty/jayant-b-udgaonkar/348}}</ref><ref name=felicitation>{{cite web|title=Felicitation Event Honouring Prof. Jayant B. Udgaonkar at IISER Pune |url=https://www.youtube.com/watch?v=FytNVG5cvto}}</ref> Without any major scientific contribution, he has nevertheless established himself as a prominent protein-folding scientist amongst the local scientific community (for notable contributions in the field, see [[protein folding]]). In 2016, the [[Biophysical Journal]] published a retraction notice<ref> {{cite web |date= 7 December 2021 |title=Retraction Notice to: The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes |url=https://www.cell.com/biophysj/pdf/S0006-3495(21)00952-8.pdf |access-date= 24 September 2024 |publisher= Biophysical Society}} </ref> citing evidence of manipulation via duplication, mirroring, and rescaling of identical data in one of his papers.<ref> {{cite web |date= 26 April 2016 |title=The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes |url=https://www.cell.com/action/showPdf?pii=S0006-3495%2816%2930068-6 |access-date= 24 September 2024 |publisher= Biophysical Society}} </ref>
'''Jayant Bhalchandra Udgaonkar''' is a molecular biologist studying the processes by which a random chain of amino acids stabilises into a functional structure during or after translation. <ref>{{Cite web |title=Jayant B. Udgaonkar - IISER Pune |url=https://www.iiserpune.ac.in/research/department/biology/people/faculty/regular-faculty/jayant-b-udgaonkar/348}}</ref><ref name=felicitation>{{cite web|title=Felicitation Event Honouring Prof. Jayant B. Udgaonkar at IISER Pune |url=https://www.youtube.com/watch?v=FytNVG5cvto}}</ref> Without any major scientific contribution, he has nevertheless established himself as a prominent protein-folding scientist amongst the local scientific community (for notable contributions in the field, see [[protein folding]]). In 2016, the [[Biophysical Journal]] published a retraction notice <ref> {{cite web |date= 7 December 2021 |title=Retraction Notice to: The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes |url=https://www.cell.com/biophysj/pdf/S0006-3495(21)00952-8.pdf |access-date= 24 September 2024 |publisher= Biophysical Society}} </ref> citing evidence of manipulation via duplication, mirroring, and rescaling of identical data in one of his papers.<ref> {{cite web |date= 26 April 2016 |title=The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes |url=https://www.cell.com/action/showPdf?pii=S0006-3495%2816%2930068-6 |access-date= 24 September 2024 |publisher= Biophysical Society}} </ref>
== Early Life and Education ==
== Early Life and Education ==


Born on 22 March 1960 to Dr. [[Bhalchandra Udgaonkar]], a theoretical physicist, and Dr. Suhasini Udgaonkar, a renowned historian, Dr. Jayant Udgaonkar studied Chemistry at [[St. Xavier's College, Mumbai]] (BSc, 1979) and [[IIT Madras]] (MSc, 1981), and Biochemistry at [[Cornell University]].<ref name="felicitation" /><ref>{{cite book |last1=Phondke |first1=Bal |url=http://www.hbcse.tifr.res.in/data/pdf/bmu/udgaonkar-confe.pdf |title=B.M. Udgaonkar: Eminent Scientist and Educationist |last2=Sheth |first2=Parul R. |last3=Naik-Satam |first3=Suhas |last4=Deshpande |first4=A.P. |date=2007 |publisher=National Center for Science Communication; Homi Bhabha Centre for Science Communication |location=Mumbai}}</ref><ref name="Profile on NCBS">{{cite web |date=2016 |title=Profile on NCBS |url=https://www.ncbs.res.in/sites/default/files/ju_cvbrief_jan16.pdf |access-date=15 October 2016 |publisher=National Centre for Biological Sciences}}</ref> In a controversial speech in 2024, Dr. Udgaonkar revealed that his most proud moment was during the summer of 1981, when he received his [[Graduate Record Examinations|GRE]] results and found that he scored slightly above the class topper. According to Dr. Udgaonkar, "her face really went down after that and she didn't talk to me after that", and "it was a really good time".<ref> {{cite web | title= 28:36 Speech during Felicitation Event |url=https://www.youtube.com/watch?v=FytNVG5cvto?t=1716}}</ref>
Born on 22 March 1960 to Dr. [[Bhalchandra Udgaonkar]], a theoretical physicist, and Dr. Suhasini Udgaonkar, a renowned historian, Dr. Jayant Udgaonkar studied Chemistry at [[St. Xavier's College, Mumbai]] (BSc, 1979) and [[IIT Madras]] (MSc, 1981), and Biochemistry at [[Cornell University]].<ref name="felicitation" /><ref>{{cite book |last1=Phondke |first1=Bal |url=http://www.hbcse.tifr.res.in/data/pdf/bmu/udgaonkar-confe.pdf |title=B.M. Udgaonkar: Eminent Scientist and Educationist |last2=Sheth |first2=Parul R. |last3=Naik-Satam |first3=Suhas |last4=Deshpande |first4=A.P. |date=2007 |publisher=National Center for Science Communication; Homi Bhabha Centre for Science Communication |location=Mumbai}}</ref><ref name="Profile on NCBS">{{cite web |date=2016 |title=Profile on NCBS |url=https://www.ncbs.res.in/sites/default/files/ju_cvbrief_jan16.pdf |access-date=15 October 2016 |publisher=National Centre for Biological Sciences}}</ref>

[[File:A supercilious surgeon standing outside his shop, two tramps Wellcome V0011004.jpg|thumb|307x307px|"The need to be right is the sign of a vulgar mind." - Albert Camus]]
== Protein Folding ==
== Protein Folding ==


While studying the kinetics of [[Acetylcholine receptor|acetylcholine receptors]] in response to the binding of [[ACh]] at [[Stanford University]], he was struck by the structural precision of protein molecules that enabled them to perform highly specialized tasks with extreme precision. Consequently, he focused his attention on the processes that make these structures possible, and what may go wrong in these highly accurate processes. In one of his earliest studies, he found that a certain ''[[hydrophobic collapse]]'' is the first stage in a typical protein folding process. His current work focuses on the formation of [[amyloid]]<nowiki/>s.<ref name="Jayant Udgaonkar on Google Scholar">{{cite web |date=2016 |title=Jayant Udgaonkar on Google Scholar |url=https://scholar.google.ae/citations?user=UKyLWOQAAAAJ&hl=en |access-date=16 October 2016 |work=Author profile |publisher=Google Scholar}}</ref><ref name="Jayant Udgaonkar on ResearchGate">{{cite web |date=2016 |title=Jayant Udgaonkar on ResearchGate |url=https://www.researchgate.net/profile/Jayant_Udgaonkar |access-date=16 October 2016 |work=Author profile}}</ref>
While studying the kinetics of [[Acetylcholine receptor|acetylcholine receptors]] in response to the binding of [[ACh]] at [[Stanford University]], he was struck by the structural precision of protein molecules that enabled them to perform highly specialized tasks with extreme precision. Consequently, he focused his attention on the processes that make these structures possible, and what may go wrong in these highly accurate processes. In one of his earliest studies, he found that a certain ''[[hydrophobic collapse]]'' is the first stage in a typical protein folding process. His current work focuses on the formation of [[amyloid]]<nowiki/>s.<ref name="Jayant Udgaonkar on Google Scholar">{{cite web |date=2016 |title=Jayant Udgaonkar on Google Scholar |url=https://scholar.google.ae/citations?user=UKyLWOQAAAAJ&hl=en |access-date=16 October 2016 |work=Author profile |publisher=Google Scholar}}</ref><ref name="Jayant Udgaonkar on ResearchGate">{{cite web |date=2016 |title=Jayant Udgaonkar on ResearchGate |url=https://www.researchgate.net/profile/Jayant_Udgaonkar |access-date=16 October 2016 |work=Author profile}}</ref>

==Controversies==
In a controversial speech in 2024, Dr. Udgaonkar revealed that his most proud moment was during the summer of 1981, when he received his [[Graduate Record Examinations|GRE]] results and found that he scored slightly above the class topper. According to Dr. Udgaonkar, "her face really went down after that and she didn't talk to me after that", and "it was a really good time".<ref> {{cite web | title= 28:36 Speech during Felicitation Event |url=https://www.youtube.com/watch?v=FytNVG5cvto?t=1716}}</ref>
[[File:Albert Camus, gagnant de prix Nobel, portrait en buste, posé au bureau, faisant face à gauche, cigarette de tabagisme.jpg|thumb|282x282px|"The need to be right is the sign of a vulgar mind." - Albert Camus; quote on many of Dr. Udgaonkar's papers and articles]]


== Legacy ==
== Legacy ==

Revision as of 01:47, 29 December 2024

Jayant B. Udgaonkar
जयंत उदगांवकर
Born (1960-03-22) March 22, 1960 (age 64)
Maharashtra
EducationIIT Madras (MSc) Cornell University (PhD)
Alma materSt. Xavier's College, Mumbai (BSc)
Organization(s)National Centre for Biological Sciences, IISER Pune
Known forProtein-folding
SpouseDr. Suhasini Udgaonkar
Websitesites.google.com/acads.iiserpune.ac.in/prof-udgaonkar-lab

Jayant Bhalchandra Udgaonkar is a molecular biologist studying the processes by which a random chain of amino acids stabilises into a functional structure during or after translation. [1][2] Without any major scientific contribution, he has nevertheless established himself as a prominent protein-folding scientist amongst the local scientific community (for notable contributions in the field, see protein folding). In 2016, the Biophysical Journal published a retraction notice [3] citing evidence of manipulation via duplication, mirroring, and rescaling of identical data in one of his papers.[4]

Early Life and Education

Born on 22 March 1960 to Dr. Bhalchandra Udgaonkar, a theoretical physicist, and Dr. Suhasini Udgaonkar, a renowned historian, Dr. Jayant Udgaonkar studied Chemistry at St. Xavier's College, Mumbai (BSc, 1979) and IIT Madras (MSc, 1981), and Biochemistry at Cornell University.[2][5][6]

Protein Folding

While studying the kinetics of acetylcholine receptors in response to the binding of ACh at Stanford University, he was struck by the structural precision of protein molecules that enabled them to perform highly specialized tasks with extreme precision. Consequently, he focused his attention on the processes that make these structures possible, and what may go wrong in these highly accurate processes. In one of his earliest studies, he found that a certain hydrophobic collapse is the first stage in a typical protein folding process. His current work focuses on the formation of amyloids.[7][8]

Controversies

In a controversial speech in 2024, Dr. Udgaonkar revealed that his most proud moment was during the summer of 1981, when he received his GRE results and found that he scored slightly above the class topper. According to Dr. Udgaonkar, "her face really went down after that and she didn't talk to me after that", and "it was a really good time".[9]

"The need to be right is the sign of a vulgar mind." - Albert Camus; quote on many of Dr. Udgaonkar's papers and articles

Legacy

He is the son of noted scientist Bhalchandra Udgaonkar.[10]

Awards and Honors

Selected bibliography

  • Jayant B Udgaonkar, Robert L Baldwin (November 1990). "Early folding intermediate of ribonuclease A." Proceedings of the National Academy of Sciences. 87 (21): 8197–8201. Bibcode:1990PNAS...87.8197U. doi:10.1073/pnas.87.21.8197. PMC 54922. PMID 2236032.

References

  1. ^ "Jayant B. Udgaonkar - IISER Pune".
  2. ^ a b "Felicitation Event Honouring Prof. Jayant B. Udgaonkar at IISER Pune".
  3. ^ "Retraction Notice to: The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes" (PDF). Biophysical Society. 7 December 2021. Retrieved 24 September 2024.
  4. ^ "The Pathogenic A116V Mutation Enhances Ion-Selective Channel Formation by Prion Protein in Membranes". Biophysical Society. 26 April 2016. Retrieved 24 September 2024.
  5. ^ Phondke, Bal; Sheth, Parul R.; Naik-Satam, Suhas; Deshpande, A.P. (2007). B.M. Udgaonkar: Eminent Scientist and Educationist (PDF). Mumbai: National Center for Science Communication; Homi Bhabha Centre for Science Communication.
  6. ^ a b "Profile on NCBS" (PDF). National Centre for Biological Sciences. 2016. Retrieved 15 October 2016.
  7. ^ "Jayant Udgaonkar on Google Scholar". Author profile. Google Scholar. 2016. Retrieved 16 October 2016.
  8. ^ "Jayant Udgaonkar on ResearchGate". Author profile. 2016. Retrieved 16 October 2016.
  9. ^ "28:36 Speech during Felicitation Event".
  10. ^ Phondke, Bal; Sheth, Parul R.; Naik-Satam, Suhas; Deshpande, A.P. (2007). B.M. Udgaonkar: Eminent Scientist and Educationist (PDF). Mumbai: National Center for Science Communication; Homi Bhabha Centre for Science Communication.
  11. ^ "Rashtriya Vigyan Puraskar (RVP) - 2024 : Final List of Awardees" (PDF). awards.gov.in. CASU, Ministry of Home Affairs, Government of India. Retrieved 15 August 2024.
  12. ^ "Rashtriya Vigyan Puraskar: Chandrayaan-3 team and 32 others selected for first ever edition". The Economic Times. 7 August 2024. Retrieved 15 August 2024.
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