Hydropathy index: Difference between revisions
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#REDIRECT [[Hydrophobicity scales]] |
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The '''hydropathy index''' of a [[protein]] is a number representing its [[hydrophilic]] or [[hydrophobic]] properties. The larger the number is, the more hydrophobic the [[amino acid]]. The most hydrophobic amino acids are [[isoleucine]] (4.5) and [[valine]] (4.2). The most hydrophilic ones are [[arginine]] (-4.5) and [[lysine]] (-3.9). This is very important in [[protein]] structure; [[hydrophobic]] amino acids tend to be internal (with regard to the protein's 3 dimensional shape) while [[hydrophilic]] amino acids are more commonly found towards the protein surface. |
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{|border="1" |
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|+ '''Hydropathy Index for the twenty natural amino acids (Kyte and Doolittle)''' |
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|A || R || N || D || C || Q || E || G || H || I || L || K || M || F || P || S || T || W || Y || V |
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|1.8 || -4.5 || -3.5 || -3.5 || 2.5 || -3.5 || -3.5 || -0.4 || -3.2 || 4.5 || 3.8 || -3.9 || 1.9 || 2.8 || -1.6 || -0.8 || -0.7 || -0.9 || -1.3 || 4.2 |
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{|border="1" |
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|+ '''Amino acids sorted by increasing hydropathy index (based on previous table)''' |
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| R || K || N || D || Q || E || H || P || Y || W || S || T || G || A || M || C || F || L || V || I |
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| -4.5 || -3.9 || -3.5 || -3.5 || -3.5 || -3.5 || -3.2 || -1.6 || -1.3 || -0.9 || -0.8 || -0.7 || -0.4 ||1.8 || 1.9 || 2.5 || 2.8 || 3.8 || 4.2 || 4.5 |
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==References== |
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*{{cite journal | last=Kyte | first=J. | coauthors=Doolittle, R. F. | year=1982 | title=A simple method for displaying the hydropathic character of a protein | journal=[[J. Mol. Biol.]] | volume=157 | issue=1 | pages=105-132 | id=PMID 7108955 }} |
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{{biochemistry-stub}} |
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[[lt:Hidropatijos indeksas]] |
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Latest revision as of 14:41, 5 July 2010
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