ActoGeniX: Difference between revisions
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'''ActoGeniX''' is a biopharmaceutical company, based in [[Ghent]], Belgium, focused on the development and commercialization of '''[[ActoBiotics]]™''', a novel class of orally available biopharmaceuticals for the targeted treatment of severe diseases with a high medical need. |
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[[ActoBiotics]]™ represent a novel concept for oral administration of therapeutic proteins, and are designed to be safer and more effective than injectable biopharmaceuticals. ActoBiotics™ can deliver a wide range of therapeutic peptides and proteins, including cytokines, enzymes, hormones and monoclonal antibodies.<ref>Steidler L & Vandenbroucke K. Genetically modified Lactococcus lactis: novel tools for drug delivery. International Journal of Dairy Technology 2006; 59, 140-146</ref><ref>http://www.ncbi.nlm.nih.gov/pubmed/20074282</ref><ref>Steidler L. Live genetically modified bacteria as drug delivery tools: at the doorstep of a new pharmacology? Expert Opinion on Biological Therapy 2004; 4, 439-441</ref><ref>Steidler L, Hans W, Schotte L, Neirynck S, Obermeier F, Falk W, Fiers W, Remaut E. Treatment of murine colitis by Lactococcus lactis secreting Interleukin-10. Science 2000; 289(5483), 1352-1355</ref> |
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''AG013'', ActoGeniX´s lead ActoBiotic™ for the treatment of [[oral mucositis]] in cancer patients has been evaluated in a phase 1B clinical trial in the US, confirming safety and tolerability as well as initial efficacy. Analysis of initial efficacy showed a 35% reduction of the percentage of days with ulcerative oral mucositis in the AG013-treated patients versus the placebo-treated patients. Furthermore, close to 30% of the patients treated with AG013 were full responders while all placebo-treated patients developed ulcerative oral mucositis.<ref>http://www.actogenix.com/eng/documents/news/pressreleases/ActoGeniX%20Press%20Release%20ENG%2015%20Sept%202011.pdf</ref> |
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In preclinical models, ActoGeniX has confirmed the broad applicability of [[ActoBiotics]]™ for a wide range of diseases, including gastrointestinal, metabolic, immune diseases and allergies. |
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ActoGeniX was founded in 2006 as a spin-off from ''[[VIB]]'' and ''[[Ghent University]]''. The Company is headquartered in Ghent (Belgium) and employs approximately 20 employees, half of whom are PhD’s, MD’s, or PharmD’s. ActoGeniX raised 35.5 million Euro (approximately 50 million US$) in two equity financing rounds from a consortium of leading life sciences investors such as [[GIMV]], [[Biotech Fund Flanders]], Baekeland Fund, [[Biovest]] (Belgium), Life Sciences Partners, Aescap Venture (The Netherlands) and Ventech (France). |
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ActoGeniX has a strong and broad intellectual property position with a patent estate encompassing more than 20 distinct patent families. |
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In April 2012, ''Prof. Chantal Mathieu'' and her team at the ''University Hospital of Leuven'' announced a major breakthrough in the treatment of [[Type 1 diabetes]] with an ActoBiotic™.<ref name="kuleuven">http://www.kuleuven.be/english/news/a-permanent-cure-for-type-1-diabetes</ref> The ActoBiotic™ can stably reinstate normal glucose levels in Type 1 diabetic mice. This innovative and effective strategy was without side effects and can now be further developed for human application. The results of the study have been published in the authoritative ''Journal of Clinical Investigation''.<ref name="jci">http://www.jci.org/articles/view/60530</ref> |
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==Indications== |
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ActoGeniX focuses on areas with unmet need in gastrointestinal, immunological and metabolic diseases: |
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* [[Oral mucositis]] <ref>Caluwaerts S, Vandenbroucke K, Steidler L, Neirynck S, Vanhoenacker P, Corveleyn S, Watkins B, Sonis S, Coulie B, Rottiers P. AG013, a mouth rinse formulation of Lactococcuslactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis. Oral Oncology 2010 Jul;46(7):564-70</ref> |
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* Inflammatory bowel disease ([[ulcerative colitis]], [[Crohn’s disease]]) <ref>http://www.ncbi.nlm.nih.gov/pubmed/19794409</ref> |
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* [[Celiac disease]] |
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* [[Type 1 diabetes]] <ref name="kuleuven"/><ref name="jci"/> |
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* [[Type 2 diabetes]] |
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* Allergic diseases |
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==References== |
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{{reflist}} |
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==External links== |
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* http://www.actogenix.com |
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{{Uncategorized|date=August 2012}} |
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Latest revision as of 02:35, 25 April 2017
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